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The COVID-19 pandemic has caused drastic disruptions to many multinational companies’ (MNCs’) supply chain management, pushing them to relocate their manufacturing activities to their home countries, a phenomenon known as reshoring. Grounded in moral psychology theory and the resource-based view, the aims of this research are to provide an extended conceptualisation of sustainable development goal (SDG) perceptions from local consumers, develop a scale, and assess this scale in relation to the reliability and validity of consumer perception of SDG antecedents and consequences in reshoring contexts from three industries, with the help of six studies. We conceptualise these perceptions on the basis of seven components (i.e. society/community wellbeing, affordable and clean energy consumption, economic growth, responsible consumption, responsible production, sustainable industrialisation and innovation, and gender equality). Using data from three distinct industries and a sample of 1075 reshoring MNC customers, we also determine how local consumers perceive and react to reshoring initiatives geared towards achieving SDGs and advocacy. The findings offer relevant implications for both the management and research of SDGs in a reshoring context at a scale level, which we describe in the form of future research directions.

Objectives To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson’s disease at early stages. Methods A total of 385 Parkinson’s disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women). Results As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only. Conclusions Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson’s disease may impact disease phenotype.

We performed a clinical study to evaluate the unawareness of dyskinesias in patients affected by Parkinson's disease (PD) and Huntington's disease (HD). Thirteen PD patients with levodopa-induced dyskinesias and 9 HD patients were enrolled. Patients were asked to evaluate the presence of dyskinesias while performing specific motor tasks. The Abnormal Involuntary Movement Scale (AIMS) and Goetz dyskinesia rating scale were administered to determine the severity of dyskinesias. The Unified Parkinson's disease rating scale (UPDRS) and Unified Huntington's Disease Rating Scale (UHDRS) were used in PD and HD patients, respectively. In PD we found a significant negative relationship between unawareness score at standing and AIMS score and between unawareness score at hand pronation-supination and AIMS score for upper limbs. In HD we found a significant positive relationship between total unawareness score and UHDRS score and between total unawareness score and disease duration. In PD the unawareness seems to be inversely related with severity of dyskinesias, while in HD it is directly related to disease duration and severity.

Introduction: Subacute sensory neuronopathy (SSN) is characterized by degeneration of T cells of dorsal root ganglia. This syndrome is associated with autoimmune diseases (i.e., Sjogren's Syndrome), tumours (i.e., small-cell lung cancer), or idiopathic. Paraneoplastic SSN is frequently associated with the presence in the serum of anti-Hu antibodies (or ANNA 1). Conversely, anti-Ri antibodies (or ANNA 2) have been associated with paraneoplastic neurological syndromes as opsoclonus-myoclonus or cerebellar degeneration. Case Report: A 62-year-old man presented subacute back pain, gait difficulty, four limbs movement uncoordination and paresthesias/dysesthesias. Neurological examination also revealed involuntary pseudoathetoid movements at upper limbs, loss of vibration sense at lower limbs and diffuse absence of deep tendon reflexes. Nerve conduction studies revealed an axonal sensory polyneuropathy. Cerebrospinal fluid proteins were raised, with increased cell count. Chest CT disclosed a lung neoplasm. Serum anti-Ri antibodies were detected using indirect immunofluorescence and confirmed by Western blotting, while anti-Hu were absent. Conclusion: We report a case of paraneoplastic subacute sensory neuronopathy associated with serum anti-Ri antibodies. To our knowledge this is the first description of such an association.