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Your search keyword '"T. Emre Kose"' showing total 2 results
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2 results on '"T. Emre Kose"'

1. Comparison of Bone Resorption Rates after Intraoral Block Bone and Guided Bone Regeneration Augmentation for the Reconstruction of Horizontally Deficient Maxillary Alveolar Ridges

Author

Eitan Mijiritsky, Elcin Bedeloglu, B. Alper Gultekin, and T. Emre Kose

Subjects
Male, medicine.medical_specialty, Bone Regeneration, Article Subject, medicine.medical_treatment, lcsh:Medicine, Dentistry, Dehiscence, Bone grafting, General Biochemistry, Genetics and Molecular Biology, Bone resorption, 03 medical and health sciences, 0302 clinical medicine, Maxilla, Tooth loss, medicine, Humans, Bone Resorption, Bone regeneration, Bone Transplantation, General Immunology and Microbiology, Guided Tissue Regeneration, business.industry, lcsh:R, Alveolar Ridge Augmentation, 030206 dentistry, General Medicine, Middle Aged, Plastic Surgery Procedures, Resorption, Surgery, Treatment Outcome, 030220 oncology & carcinogenesis, Linear Models, Clinical Study, Female, Collagen, Implant, medicine.symptom, business
Abstract

Purpose. Bone atrophy after tooth loss may leave insufficient bone for implant placement. We compared volumetric changes after autogenous ramus block bone grafting (RBG) or guided bone regeneration (GBR) in horizontally deficient maxilla before implant placement. Materials and Methods. In this retrospective study, volumetric changes at RBG or GBR graft sites were evaluated using cone-beam computed tomography. The primary outcome variable was the volumetric resorption rate. Secondary outcomes were bone gain, graft success, and implant insertion torque. Results. Twenty-four patients (28 grafted sites) were included (GBR, 15; RBG, 13). One patient (RBG) suffered mucosal dehiscence at the recipient site 6 weeks after surgery, which healed spontaneously. Mean volume reduction in the GBR and RBG groups was 12.48 ± 2.67% and 7.20 ± 1.40%, respectively. GBR resulted in significantly more bone resorption than RBG (P<0.001). Mean horizontal bone gain and width after healing were significantly greater in the GBR than in the RBG group (P=0.002 and 0.005, resp.). Implant torque was similar between groups (P>0.05). Conclusions. Both RBG and GBR hard-tissue augmentation techniques provide adequate bone graft volume and stability for implant insertion. However, GBR causes greater resorption at maxillary augmented sites than RBG, which clinicians should consider during treatment planning.

Published
2016
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2. Melatonin improves periodontitis-induced kidney damage by decreasing inflammatory stress and apoptosis in rats.

Author

Kose O, Kurt Bayrakdar S, Unver B, Altin A, Akyildiz K, Mercantepe T, Bostan SA, Arabaci T, Turker Sener L, Emre Kose T, Tumkaya L, Yilmaz A, and Kuluslu G

Subjects
Animals, Apoptosis, Disease Models, Animal, Kidney, Male, Oxidative Stress, Rats, Rats, Sprague-Dawley, Alveolar Bone Loss drug therapy, Melatonin therapeutic use, Periodontitis complications, Periodontitis drug therapy
Abstract

Background: Two main aims of this animal study were to inspect the possible effects of periodontitis on the structure and functions of the kidneys and the therapeutic effectiveness of melatonin., Methods: Twenty-four male Sprague-Dawley rats were randomly divided into three groups: control, experimental periodontitis (Ep), and Ep-melatonin (Ep-Mel). Periodontitis was induced by placing 3.0-silk sutures sub-paramarginally around the cervix of right-left mandibular first molars and maintaining the sutures for 5 weeks. Then melatonin (10 mg/kg body weight/day, 14 days), and the vehicle was administered intraperitonally. Mandibular and kidney tissue samples were obtained following the euthanasia. Periodontal bone loss was measured via histological and microcomputed tomographic slices. On right kidney histopathological and immunohistochemical, and on the left kidney biochemical (malonyl-aldehyde [MDA], glutathione, oxidative stress [OSI], tumor necrosis factor [TNF]-α, interleukin [IL]-1β, matrix metalloproteinase [MMP]-8, MMP-9, and cathepsin D levels) evaluations were performed. Renal functional status was analyzed by levels of serum creatinine, urea, cystatin-C, and urea creatinine., Results: Melatonin significantly restricted ligature-induced periodontal bone loss (P <0 .01) and suppressed the levels of proinflammatory cytokines (TNF-α and IL-1β), oxidative stress (MDA and OSI), and proteases (MMP-8, MMP-9, and CtD) that was significantly higher in the kidneys of the rats with periodontitis (P <0.05). In addition, periodontitis-related histological damages and apoptotic activity were also significantly lower in the Ep-Mel group (P <0.05). However, the markers of renal function of the Ep group were detected slightly impaired in comparison with the control group (P >0.05); and the therapeutic activity of melatonin was limited (P >0.05)., Conclusion: Melatonin restricts the periodontitis-induced inflammatory stress, apoptosis, and structural but not functional impairments., (© 2020 American Academy of Periodontology.)

Published
2021
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