1. Coinfection with HIV and hepatitis C virus in 229 children and young adults living in Europe
- Author
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T. Kaleeva, Evgeny Voronin, David Moreno-Pérez, María Méndez, Olga Calavia, Antonio Mur, Carlo Giaquinto, María Luisa Navarro Gómez, Tessa Goetghebuer, Neus Rius, Lluis Mayol, Mercedes Gracia, Irina Raus, Santiago Jiménez de Ory, José Tomás Ramos, Kathleen Mantzsch, Carlos Rodrigo, Vania Giacomet, Carlos M. Pérez, Ulrich Baumann, Christoph Rudin, Claudia Fortuny, Konstantin Dodonov, Maurizio de Martino, Lola Falcón Neyra, Lourdes Garcia, Giuseppe Indolfi, O. Glutshenko, Ali Judd, Luminita Ene, María T. Coll, Dan Duiculescu, Elena Rincón, Marc Hainaut, Juan Luis Santos, Inga Latysheva, Alfredo Guarino, Pere Soler-Palacín, Anna Turkova, Silvia Martinazzi, Laura Ambra Nicolini, Filippo Del Puente, Núria Rovira, Pablo Rojo, Miluca García, Angela Miniaci, Magdalena Marczyńska, Christoph Königs, Svetlana Soloha, Evelyne Van der Kelen, Antoni Soriano-Arandes, Joaquín Escribano, Claire Thorne, Luisa Galli, César Gavilán, Carmen López, Clara Gabiano, Z. Ruban, Y. Baryshnikova, Sabina Dobsz, José Couceiro, María Espiau, Natalia Primak, N. Bashkatova, Milana Miloenko, Alla Volokha, Ruslan Malyuta, Antoni Noguera-Julian, Talía Sainz, Galina Kiseleva, María T. Valmanya, Olaf Neth, Andrea Duppenthaler, Pedro Terol, Elisabetta Venturini, Esmeralda Nuñez, María José Mellado, Carmen Otero, Valentí Pineda, European Commission, and Janssen Biotech
- Subjects
Liver Cirrhosis ,Male ,Pediatrics ,medicine.medical_specialty ,Vertical infection ,Adolescent ,Hepatitis C virus ,Immunology ,Human immunodeficiency virus (HIV) ,HIV Infections ,medicine.disease_cause ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Coinfection ,Hepatitis C ,HIV ,Paediatric ,Immunology and Allergy ,Infectious Diseases ,medicine ,Humans ,030212 general & internal medicine ,Young adult ,Child ,Retrospective Studies ,business.industry ,virus diseases ,Infant ,Hepatitis C, Chronic ,medicine.disease ,digestive system diseases ,3. Good health ,Europe ,Cross-Sectional Studies ,Child, Preschool ,030211 gastroenterology & hepatology ,Female ,business ,coinfection ,hepatitis C ,paediatric ,vertical infection ,Demography - Abstract
[Objective] To characterize children, adolescents and young adults infected with HIV/hepatitis C virus (HCV) vertically or before age of 18 years and living in Europe regarding mode of acquisition, HCV genotype, clinical status and treatment., [Design] Retrospective, cross-sectional study using pooled data from 11 European paediatric HIV cohorts., [Methods] Patients aged more than 18 months and less than 25 years, with HIV/HCV acquired vertically or in childhood, were included. Anonymized individual patient data were collected using a standard protocol and modified HIV Cohorts Data Exchange Protocol., [Results] Of 229 patients included, 142 (62%) had vertically acquired infection. Median age at last follow-up was 16.2 years. Most children had HCV genotype 1 (101/184, 55%) or 3 (57/184, 31%). One-fifth (46/214) had a previous AIDS diagnosis (data missing on prior AIDS diagnoses for 15). At their last clinic visit, 70% (145/208) had no/mild immunosuppression (Centers for Disease Control and Prevention stage 1), and 131 of 179 on antiretroviral therapy had undetectable HIV RNA (assay thresholds varied from, [Conclusion] The high proportion of patients with progressive liver disease underscores the need for close monitoring and earlier and more effective HCV treatment., This work was supported by funding from the EU Seventh Framework Programme (FP7/2007–2013) under EuroCoord grant agreement [no. 260694] and additional funding from Janssen.
- Published
- 2016