126 results on '"T. Lazure"'
Search Results
2. National multicentric evaluation of quality of pathology reports for rectal cancer in France in 2016
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Anne Rullier, Céline Bazille, M. Desrousseaux, A. Daubech, Catherine Julie, F. Thélu, F. Le Pessot, B. Turlin, S. Stanislas, M.-S. Bordier, Armelle Bardier, C. Boutanos, Marie-Hélène Laverriere, R.-P. Eyremandi, A. Rousseau, T. Lazure, Janick Selves, Frédéric Bibeau, Nathalie Guedj, Magali Svrcek, M. Capdepont, Flora Poizat, B. Bonhomme, A. Demoures, Service de pathologie [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Service de Pathologie [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Pathologie Nord Unilabs, Hôpital Beaujon, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Hôpital Beaujon [AP-HP], Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Service de Pathologie [Rennes] = Pathology [Rennes], CHU Pontchaillou [Rennes], Service d'Anatomie et cytologie pathologiques = Service de Pathologie [CHU Pitié-Salpêtrière] (ACP), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Pathologie [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Institut Bergonié [Bordeaux], UNICANCER, CHU Grenoble, Service de pathologie [CHU Ambroise Paré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré [AP-HP], Centre hospitalier de Pau, Département de Pathologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Hôpital Bicêtre, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Centre Hospitalier Libourne, Hopital de Périgueux, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Hôpital Beaujon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Service de pathologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Hôpital Bicêtre-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)
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Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Colorectal cancer ,medicine.medical_treatment ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Routine practice ,Pathology and Forensic Medicine ,03 medical and health sciences ,Quality report ,0302 clinical medicine ,Pathology report ,medicine ,Rectal Adenocarcinoma ,Humans ,Venous Invasion ,Rectal cancer ,Molecular Biology ,Aged ,Neoplasm Staging ,Rectal Neoplasms ,business.industry ,Chemoradiotherapy ,Cell Biology ,General Medicine ,Pathology Report ,Middle Aged ,medicine.disease ,Neoadjuvant Therapy ,3. Good health ,Radiation therapy ,Treatment Outcome ,030104 developmental biology ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Concomitant ,Neoadjuvant radiochemotherapy ,Lymph Node Excision ,Female ,Radiotherapy, Adjuvant ,France ,Lymph Nodes ,business - Abstract
International audience; The quality of pathologic assessment of rectal cancer specimens is crucial for treatment efficiency and survival. The Royal College of Pathologists (RCP) recommends evaluating the quality of the pathology report in routine practice using three quality indicators (QIs): the number of lymph nodes (LNs) analyzed (≥ 12), the rate of venous invasion (VI ≥ 30%), and peritoneal involvement (pT4a ≥ 10%). In this study, we evaluated the three QIs of the French national pathology reports and compared them with British guidelines and assessed the influence of neoadjuvant radiochemotherapy on QIs. From January 1 to December 31, 2016, all pathology reports for rectal adenocarcinoma were collected from French departments. Neoadjuvant radiochemotherapy included long-course radiotherapy with concomitant 5-FU-based chemotherapy. A total of 983 rectal cancer pathology reports were evaluated. A median of 15 LNs were analyzed and 81% of centers had ≥ 12 LNs. The rate of VI was 30% and 41% of centers had ≥ 30% VI. The rate of pT4a was 4% and 18% of centers reported ≥ 10% pT4a. None of the centers reached the threshold for the three QIs. All three QIs were lower after radiochemotherapy compared to surgery alone. In conclusion, in French routine practice, the values of two of the three QIs (LNs analyzed and VI) were globally in line with RCP guidelines. However, the rate of pT4a was very low, particularly after radiochemotherapy, suggesting its low value in rectal cancer.
- Published
- 2019
3. OP0307 Treatment of baff transgenic mice with ANTI-TNF: monoclonal ANTI-TNF are associated with a higher risk of lymphoma than etanercept
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G Nocturne, L Bineta, S Boudaoud, J Pascaud, R Seror, C Nicco, C Chereau, F Mackay, F Vincent, T Lazure, S Ferlicot, L Stimmer, S Roulland, R Krzysiek, S Hacein-Bey, F Batteux, and X Mariette
- Published
- 2017
4. Granulome éosinophile : un diagnostic non réservé aux enfants
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T. Lazure, Y. Menu, A. Miquel, and S. Espinoza
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Radiology, Nuclear Medicine and imaging - Abstract
Resume Le granulome eosinophilique est la manifestation la plus frequente de l’histicytose langheransienne ; il se rencontre le plus souvent chez l’enfant. Nous en rapportons une observation chez un homme de 30 ans chez qui des douleurs de la hanche ont fait decouvrir une lacune osteolytique de l’acetabulum. L’examen histologique de la biopsie radioguidee a montre la presence de cellules de Langerhans caracterisees par l’immunomarquage par l’anticorps anti-CD1a. Le traitement local par injection d’un derive cortisone a entraine une recalcification partielle de la lesion, ainsi que la regression des douleurs.
- Published
- 2007
5. Facteurs de risque d’acquisition de lésions du col utérin dans une population de femmes infectées par le VIH
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I. Cartier, M. Mole, C. Goujard, S. Fridmann, Jean-François Delfraissy, Faroudy Boufassa, D. Peretti, and T. Lazure
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Gynecology ,medicine.medical_specialty ,Uterine cervix ,Reproductive Medicine ,business.industry ,Human immunodeficiency virus (HIV) ,Follow up studies ,Obstetrics and Gynecology ,Medicine ,General Medicine ,business ,medicine.disease_cause ,Premalignant lesion - Abstract
Journal de Gynecologie Obstetrique et Biologie de la Reproduction - Vol. 35 - N° 5 - p. 490-496
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- 2006
6. Échinococcose alvéolaire hépatique
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T. Lazure, A-S Rangheard, B. Bessoud, Yves Menu, E. Mesiat, and S. Dimet
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business.industry ,Medicine ,Radiology, Nuclear Medicine and imaging ,Nuclear medicine ,business - Abstract
Resume Correlation radiologique et pathologique chez un homme porteur d’une echinococcose alveolaire hepatique. Le diagnostic est evoque en imagerie devant une masse infiltrante, multikystique souvent responsable d’une dilatation des voies biliaires. La mise en evidence du parasite au decours permet d’affirmer le diagnostic.
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- 2005
7. Tumeur stromale gastro-intestinale
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T. Lazure, S. Dimet, Bertrand Bessoud, Y. Menu, and A-S Rangheard
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Radiology, Nuclear Medicine and imaging - Abstract
Resume La notion de tumeur stromale ou GIST est relativement recente et correspond a une tumeur mesenchymateuse du tube digestif developpee a partir des cellules de Cajal. Decouvertes le plus souvent devant une anemie ou des episodes d’hematemeses ou de melena, ces tumeurs sont souvent evoquees en imagerie tomodensitometrique devant une tumeur a developpement exophytique, bien limitee, dont le rehaussement et le caractere necrotique sont correles a leur degre de malignite.
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- 2005
8. Diverticule duodénal intraluminal
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A-S Rangheard, Y. Menu, S. Dimet, T. Lazure, and Bertrand Bessoud
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medicine.medical_specialty ,business.industry ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,business ,Nuclear medicine ,Gastroenterology - Abstract
Resume Correlation radiologique et pathologique chez un jeune homme porteur d’un diverticule intra-luminal du deuxieme duodenum revele par une pancreatite aigue. Le diagnostic repose sur les donnees endoscopiques et scanographiques. L’examen anatomo-pathologique permet de faire le diagnostic differentiel avec un choledochocele.
- Published
- 2005
9. Myélofibrose auto-immune secondaire à une dermatomyosite
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Jade Ghosn, S. Sahali, T. Lazure, Olivier Lambotte, Jean-François Delfraissy, and Cécile Goujard
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Gastroenterology ,Follow up studies ,Dermatomyositis ,medicine.disease ,medicine.disease_cause ,Dermatology ,Autoimmunity ,Pharmacotherapy ,Biopsy ,Internal Medicine ,medicine ,Myelofibrosis ,business ,Myositis - Abstract
We report a second observation of autoimmune myelofibrosis associated with an inflammatory myositis in a 30-year-old female. The links between myelofibrosis and autoimmunity are discussed.
- Published
- 2009
10. Une première observation de périartérite rénale typique associée à une polyglobulie secondaire compliquant une maladie associée aux IgG4 (IgG4-RD)
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G. Cluzel, F. Daoued, Xavier Mariette, H. François, R. Seror, T. Lazure, J. Rohmer, and F.X. Danlos
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Gastroenterology ,Internal Medicine - Abstract
Introduction Nous decrivons une premiere observation de periarterite renale isolee responsable d’une polyglobulie secondaire s’integrant dans le cadre d’une maladie associee aux IgG4 ou « IgG4-Related Disease » (IgG4-RD). Observation Un homme d’origine tunisienne, âge de 60 ans est adresse dans le service pour l’exploration d’une parotidomegalie bilaterale. Dans ses antecedents, on notait une hypertension arterielle et un diabete de type 2. L’anamnese objectivait un bon etat general, une xerostomie, une parotidomegalie depuis 2 ans et depuis plusieurs semaines la presence de cephalees inhabituelles. Cliniquement, on notait un test de Schirmer Discussion L’IgG4-RD est definie histologiquement par la presence d’un infiltrat lymphoplasmocytaire riche en plasmocytes IgG4 positif et d’une fibrose. Dans notre observation, l’atteinte parotidienne chez un homme de 60 ans atteint de xerostomie en l’absence d’anticorps anti-SSA et anti-SSB etait evocatrice. Il a ete decrit dans cette maladie d’une part des atteintes vasculaires ischemiques essentiellement des gros troncs de type peri-aortite, d’autre part des atteintes renales de type nephrite tubulo-interstitielle. Dans notre observation, il s’agit d’une atteinte renale de type PAN typique avec des micro-anevrismes et des infarctus renaux confirmes par l’arteriographie. L’absence d’effondrement de l’erythropoietine elimine une polyglobulie primitive. Compte tenu de la normalisation de l’hemoglobine sous corticoides, il est tres probable que cette polyglobulie etait secondaire a une secretion renale anormale d’erythropoietine probablement du fait de l’hypoxie. Malheureusement, en raison des risques de la biopsie renale du fait des micro-anevrysmes, l’examen qui aurait pu confirmer cette hypothese n’a pas ete effectue compte tenu de l’absence de consequence therapeutique pour le patient. Conclusion Notre observation est la premiere d’une periarterite renale compliquee d’une polyglobulie symptomatique, survenant dans le cadre d’une IgG4-RD.
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- 2014
11. [Poorly differentiated large cell endocrine carcinoma of the extrahepatic bile ducts]
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C, Demoreuil, A, Thirot-Bidault, C, Dagher, R, Bou-Farah, C, Benbrahem, T, Lazure, F, Gayral, and C, Buffet
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Male ,Bile Duct Neoplasms ,Bile Ducts, Extrahepatic ,Carcinoma ,Humans ,Aged - Abstract
We report a case of a poorly differentiated endocrine large cell carcinoma of the extrahepatic bile ducts in a 73-year-old man, revealed by abdominal pain, jaundice and weight loss. Computed tomography and endoscopic retrograde cholangiography found tumoral stenosis of the main bile duct. Brush cytology detected tumor cells. Pathological examination of the resected bile duct disclosed a high-grade large cell carcinoma with morphological endocrine features and positivity for chromogranin A. This tumor was associated with a minor component of adenocarcinomatous cells. Despite polychemotherapy, the patient had widely metastatic disease a few months later. We discuss here the histogenesis of this tumor as well as its nosological position among the endocrine and mixed tumors of bile ducts.
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- 2008
12. [Autoimmune myelofibrosis with dermatomyositis]
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S, Sahali, J, Ghosn, T, Lazure, C, Goujard, J-F, Delfraissy, and O, Lambotte
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Adult ,Time Factors ,Biopsy ,Anti-Inflammatory Agents ,Puerperal Disorders ,Mycophenolic Acid ,Dermatomyositis ,Autoimmune Diseases ,Primary Myelofibrosis ,Humans ,Prednisone ,Drug Therapy, Combination ,Female ,Dermatologic Agents ,Glucocorticoids ,Follow-Up Studies - Abstract
We report a second observation of autoimmune myelofibrosis associated with an inflammatory myositis in a 30-year-old female. The links between myelofibrosis and autoimmunity are discussed.
- Published
- 2007
13. THU0395 Low Numbers of Blood and Salivary Natural Killer Cells are Associated with a Better Response to Belimumab in Primary Sjogren's Syndrome: Results of the Beliss Study
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T. Lazure, F. Desmoulins, R. Belkhir, Yassine Taoufik, R. Seror, M. Benbijja, Xavier Mariette, Houria Hendel-Chavez, P. Ravaud, and Gaetane Nocturne
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business.industry ,Lymphocyte ,medicine.medical_treatment ,Immunology ,Phases of clinical research ,Inflammation ,medicine.disease ,Sialadenitis ,Belimumab ,General Biochemistry, Genetics and Molecular Biology ,medicine.anatomical_structure ,Cytokine ,Rheumatology ,medicine ,Immunology and Allergy ,medicine.symptom ,B-cell activating factor ,business ,CD8 ,medicine.drug - Abstract
Background The BAFF (or BLyS) cytokine plays a key role in pathogenesis of primary Sjogren9s syndrome (pSS), thus testing belimumab (biological treatment inhibiting soluble BAFF/BLyS) in pSS patients, seems appealing. Clinical results of the BELISS study have been previously reported [1]. Objectives To address changes in blood lymphocyte sub-populations and labial salivary gland (LSG) inflammation after belimumab in patients with primary Sjogren9s syndrome (pSS) and identify predictors of response to treatment.To address changes in blood lymphocyte sub-populations and labial salivary gland (LSG) inflammation after belimumab in patients with primary Sjogren9s syndrome (pSS) and identify predictors of response to treatment. Methods Sequential blood lymphocyte subsets and LSG biopsies were analysed between week 0 (W0) and W28 in 15 pSS patients (all females, median age =44 [36.5-63.5] years, median disease duration=1 [0.5-6.5] years) treated with belimumab. Systemic response to treatment was defined as a decrease of the ESSDAI ≥3 points at W28. Results After belimumab, we observed a decrease in blood B lymphocytes primarily involving CD27-IgD+ naive B-cells (151 [24-186] at W0 vs 10 [6-40] at W28, p=0.008, n=9). No significant change in the total lymphocyte, total T-cell, CD4 or CD8 T-cell counts was observed. By contrast, there was a significant increase in the number of NK cells (p=0.032) Regarding histological pattern, lymphocytic sialadenitis (focus score >1) present in 12 (80.0%) patients before belimumab, became negative in 5 after treatment (p=0.03). The median LSG B-cell /T-cell ratio decreased from 0.58 [0.5-0.67] to 0.50 [0.5-0.5] (p=0.06). BAFF staining was detected in 11/14 (78.6%) patients, before, compared to 7/14 (50.0%) after belimumab (p=0.10). The median percentage of BAFF positive cells in foci significantly decreased from 27.5% [10-40] to 5% [0-20], after belimumab (p=0.03). Systemic response was obtained in 6 (40%) patients. The only predictor of response was the presence of a low number of NK cells both in blood (8.5% [7-10] vs. 11% [9-21], p=0.04) and in LSG (20.6/mm 3 [20.0-21.4] vs 30.0/mm 3 [25.0-100.0], p=0.003). Serum BAFF levels did not influence response to treatment. Conclusions Low blood and salivary NK cells numbers are associated with a better response to belimumab. This suggests that 2 distinct subsets of pSS may exist: one with predominant type-I INF/BAFF/B-cell axis, good responders to belimumab, and one with predominant type-II IFN/NK-cell axis, non-responders. References Mariette X, Seror R, Quartuccio L, Baron G, Salvin S, Fabris M, et al. Efficacy and safety of belimumab in primary Sjogren9s syndrome: results of the BELISS open-label phase II study. Annals of the rheumatic diseases. 2013. Disclosure of Interest None declared
- Published
- 2015
14. [Risk factors for incident cervical intraepithelial neoplasia (CIN) among HIV-infected women: a prospective study]
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S, Fridmann, F, Boufassa, I, Cartier, D, Peretti, T, Lazure, M, Mole, J-F, Delfraissy, and C, Goujard
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Adult ,Humans ,Uterine Cervical Neoplasms ,Female ,HIV Infections ,France ,Prospective Studies ,Middle Aged ,Uterine Cervical Dysplasia ,Follow-Up Studies - Abstract
To study risk factors for incident cervical intraepithelial neoplasia (CIN) among HIV-infected women.Prospective study of a population of 97 HIV-infected women with normal Pap smear at inclusion.Fourteen CIN (diagnosed by colposcopy and confirmed with biopsy) were observed within a median follow-up of 38 months (13 CIN 1, one CIN 2). The incidence of cervical lesions was estimated to be 2%, 7% and 10% respectively at one year, two and three years after inclusion, The time to occurrence was very variable (ranging from 7 months to 6 years) among our patients. No known risk factors, in particular neither the CD4 cell count nor antiretroviral treatment, were identified to be associated with occurrence of CIN in our study population.Regardless of their immune status and HIV treatments, extensive and prolonged gynaecological follow up of HIV-infected women remains necessary.
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- 2006
15. [A swelling of the wrist]
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C, Amy, T, Lazure, J F, Bruch, J F, Cazagou, and P, Bedossa
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Male ,Histiocytoma, Benign Fibrous ,Humans ,Hemorrhage ,Wrist ,Child - Published
- 2002
16. [Gastric epithelioid angiosarcoma, a biopsy diagnostic pitfall]
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C, Amy, T, Lazure, J P, Sales, O, Languille-Mimoune, P, Callard, P, Bedossa, and M, Fabre
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Diagnosis, Differential ,Intestines ,Male ,Fatal Outcome ,Stomach Neoplasms ,Biopsy ,Hemangiosarcoma ,Humans ,Antineoplastic Agents ,Aged - Abstract
We report the case of a 70-year-old man who presented a bulky gastric mass. The diagnosis of poorly differenciated adenocarcinoma was made on the biopsy. On surgical specimen, the final diagnosis of gastric angiosarcoma with secondary intestinal involvement was established. The patient did not respond to chemotherapy and died 8 months later. The diagnosis was difficult because of epithelioid areas which expressed both cytokeratin and vascular antigens. Human herpesvirus 8 previously detected in some soft tissue angiosarcoma was not found by polymerase chain reaction.
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- 2002
17. IgG4 multiorgan lymphoproliferative syndrome as a differential diagnosis of primary Sjogren's syndrome in men?
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Xavier Mariette, Yassine Taoufik, Stephan Pavy, T. Lazure, Corinne Miceli, and Gaetane Nocturne
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Systemic disease ,Pathology ,medicine.medical_specialty ,business.industry ,Immunology ,medicine.disease ,General Biochemistry, Genetics and Molecular Biology ,Thyroiditis ,stomatognathic diseases ,stomatognathic system ,Rheumatology ,Mikulicz Disease ,Plasma cell infiltration ,parasitic diseases ,medicine ,Immunology and Allergy ,Differential diagnosis ,Sjogren s ,business ,Autoimmune pancreatitis - Abstract
In 1888, Mikulicz-Radecki reported a case exhibiting bilateral, painless and symmetrical swellings of the lacrimal, parotid and submandibular glands. In 1953, Morgan and Castleman suggested that Mikulicz disease (MD) should be reconsidered as one of the manifestations of primary Sjogren's syndrome (pSS) as they shared many histopathological characteristics. But recently, several groups demonstrated that MD may differ from pSS. Actually, MD may partly be an IgG4-related systemic disease, the other components of which are still undelineated and include autoimmune pancreatitis, chronic sclerosing sialoadenitis, Riedel's thyroiditis, some cases of cholangitis, retroperitoneal fibrosis.1 Masaki defined a new clinical entity, the IgG4 multiorgan lymphoproliferative syndrome (MOLPS), which includes these manifestations.2 It is characterised by hyper-IgG4 γ-globulinaemia and IgG4 plasma cell infiltration. There are a number of differences with …
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- 2011
18. Infections fongiques à champignons dématies chez deux patients transplantés rénaux
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Adela Angoulvant, Yaye Senghor, N. Dahane, C. Frances, P. Callard, Christophe Hennequin, B. Wyplosz, Juliette Guitard, and T. Lazure
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Infectious Diseases - Published
- 2014
19. [Primary uterine and vulvar Ewing's sarcoma/peripheral neuroectodermal tumors in children: two unusual locations]
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T, Lazure, I A, Alsamad, S, Meuric, D, Orbach, and M, Fabre
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Adolescent ,Vulvar Neoplasms ,Sarcoma, Ewing ,12E7 Antigen ,Magnetic Resonance Imaging ,Vulva ,Fatal Outcome ,Antigens, CD ,Antineoplastic Combined Chemotherapy Protocols ,Uterine Neoplasms ,Humans ,Female ,Neuroectodermal Tumors, Primitive, Peripheral ,Cell Adhesion Molecules - Abstract
Two genital cases of Ewing's sarcoma/peripheral neuroectodermal tumor in 14 and 15 year old teenagers are reported. They arose in uteri and vulva, as small round cell tumors with some rosette-like formations and intense membranous immunoreactivity for CD99. The EWS/FLI-1 transcript was present in the vulvar tumor. Under chemotherapy, uterine tumor outcome was fatal within 9 months. The vulvar lesion was treated by surgery and chemotherapy, without relapse after 7 months. Likewise to these 2 cases, the literature seems to indicate different prognosis for uterine and vulvar tumors.
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- 2001
20. Pleomorphic rhabdomyosarcoma of the uterine corpus: a case report
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D, Colin, T, Lazure, M, Fabre, J C, De Watteville, and P, Bedossa
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Diagnosis, Differential ,Rhabdomyosarcoma ,Uterine Neoplasms ,Humans ,Female ,Aged ,Ultrasonography - Published
- 2001
21. [An uncommon mastoid cyst. What is your diagnosis? Diagnosis: ceruminous cystic adenoma]
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M, Lae, S, Kici, T, Lazure, J, Quillard, M, Wassef, and P, Bedossa
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Diagnosis, Differential ,Male ,Cerumen ,Cysts ,Humans ,Middle Aged ,Carcinoma, Adenoid Cystic ,Ear Neoplasms ,Mastoid - Published
- 2000
22. [Stomatococcus mucilaginosus infection. A rare cause of cutaneous histiocytic infiltrate]
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T, Lazure, S, Fraitag, M, Huerre, A, Sautet, F, Jaubert, and N, Brousse
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Male ,Neutropenia ,Adolescent ,Humans ,Histiocytes ,Skin Diseases, Bacterial ,Gram-Positive Bacterial Infections - Abstract
We report the case of a systemic infection due to Stomatococcus mucilaginosus with cutaneous localisations occurring in a neutropenic child. The histological features of this cutaneous involvement are very unusual and the diagnosis can be suggested before bacteriological results.
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- 1998
23. Une cause rare d'endocardite de Loeffler: la maladie de Kimura
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A. Bouchachi, S. Barges, F. Mechaï, Olivier Lambotte, T. Lazure, and Cécile Goujard
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Gastroenterology ,Internal Medicine - Published
- 2006
24. OP0113 Modification of Salivary Gland Lymphocyte Pattern after Belimumab in Primary Sjogren’s Syndrome: Results of the Beliss Study
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T. Lazure, Xavier Mariette, Stephan Pavy, F. Desmoulins, R. Seror, C. Miceli-Richard, and P. Ravaud
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CD20 ,Systemic lupus erythematosus ,biology ,business.industry ,medicine.medical_treatment ,T cell ,Lymphocyte ,Immunology ,medicine.disease ,Belimumab ,Sialadenitis ,General Biochemistry, Genetics and Molecular Biology ,stomatognathic diseases ,Cytokine ,medicine.anatomical_structure ,stomatognathic system ,Rheumatology ,medicine ,biology.protein ,Immunology and Allergy ,B-cell activating factor ,business ,medicine.drug - Abstract
Background The BAFF (or BLyS) cytokine plays a key role in pathogenesis of primary Sjogren’s syndrome (pSS). The level of BAFF is increased in the serum and BAFF may be expressed by salivary epithelial cells and the lymphoid infiltrate of salivary glands. Moreover, BAFF is induced by innate immunity stimulation, the later playing a role in pSS pathogenesis. Belimumab, the first biological treatment inhibiting soluble BAFF/BLyS has proved its effectiveness in systemic lupus and has been recently approved for this indication. Lupus and pSS share a lot of pathogenic mechanism including interferon signature and BAFF involvement. Thus we run the first open label study of belimumab in pSS patients and recently showed that 19/30 patients (63%) achieved the primary end-point which was a composite clinico-biological outcome. Objectives To address the change in labial salivary gland (LSG) inflammation after Belimumab therapy Methods Patients were included in 2 parallel and identical studies in 2 European Centres. Patients had to fulfill AECG criteria, to be anti-SSA/SSB positive and had to have at the time of inclusion either systemic complications or early disease ( Minor labial salivary gland (LSG) biopsies of the 15 patients (all female, mean age=50 yrs, mean disease duration= 5 yrs) from the French center, performed at W0 and W28, were analyzed for estimating the focus score, the B-cell/T-cell ratio (CD20 and CD3 staining), BAFF expression (BAFF (Buffy-2) staining) and NK infiltrate (NKp46 staining). Results Before treatment, significant lymphocytic sialadenitis (focus score >1) was observed in 11 (78.6%) patients before treatment, five of whom became negative (focus score B-cell /T cell ratio decreased after treatment in 5 patients and remained stable in all other patients (median ratio decreased from 0.58 to 0.50, p=0.055). Before treatment, a BAFF staining was detected in 11/14 (78.6%) patients, and in only 7/14 (50.0%) after belimumab (p=0.07). The median percentage of BAFF positive cells in foci significantly decreased from 27.5% to 5% after belimumab therapy (p=0.03). NKp46 staining revealed that NK cells infiltrate was predominantly located in interstitium rather than in foci (median number of NK cell: 24.7 vs. 8.2/mm², p=0.0003), and did not change after belimumab. Conclusions There was a clear tendency in favour of a decrease in foci number, B cells and BAFF-expressing cells within LSG after belimumab therapy. It is tempting to interpret the decrease in BAFF staining as an effect of the drug on membrane BAFF-expressing cells, but it could be also only due to the decrease in B cells expressing BAFF receptors linked to soluble BAFF passively stained by the anti-BAFF antibody. After belimumab therapy, we observed regression of lymphocytic infiltration of LSG in one third of the patients. Also the percentage of BAFF positive cells significantly decreased with a trend to a decrease of B-cell/T-cell ratio. Disclosure of Interest None Declared
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- 2013
25. OP0023 Germinal and Somatic Genetic Variants of TNFAIP3 Promote Lymphomagenesis Process Complicating Primary Sjögren’s Syndrome
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Saida Boudaoud, Say Viengchareun, Gaetane Nocturne, Jörg Tost, C. Miceli Richard, Eric Hachulla, Florence Busato, K. E. Taylor, T. Lazure, J. Melki, J.-E. Gottenberg, Averil Ma, Joanne Nititham, Xavier Mariette, J.-J. Dubost, Marc Lombès, and Lindsey A. Criswell
- Subjects
business.industry ,Immunology ,Single-nucleotide polymorphism ,MALT lymphoma ,medicine.disease ,medicine.disease_cause ,TNFAIP3 ,General Biochemistry, Genetics and Molecular Biology ,Lymphoma ,Autoimmunity ,Exon ,Rheumatology ,BCL9 ,immune system diseases ,hemic and lymphatic diseases ,medicine ,Immunology and Allergy ,business ,Gene - Abstract
Background The pathophysiology of lymphomas in auto immune disease (AID) involves persistent inflammation and activation of autoimmune B cells leading to NF-kB activation. The TNFAIP3 gene encodes the A20 protein, a central gatekeeper of NF-kB activation. Germinal abnormalities in TNFAIP3 have been associated with different AID and somatic mutations of the gene have been observed in several lymphoma subtypes, particularly MALT lymphoma, the lymphoma subtype most frequently associated with pSS. Objectives To investigate whether TNFAIP3 abnormalities are involved in the lymphomagenesis process in pSS. Methods The discovery set was constituted by 584 pSS patients including 25 patients with lymphoma and 451 controls of Caucasian ancestry, addressed by 48 Ancestry Informative Markers. Three SNPs encompassing the TNFAIP3 locus located on 6q23 (rs13192841, rs2230926 and rs6922466) and known to be associated with SLE and RA were genotyped. 19 additional patients with pSS and lymphoma were used for extension and replication. We sequenced all TNFAIP3 exons in germinal and lymphoma DNA from 20 pSS patients with lymphoma. Functional abnormalities of A20 were assessed by gene reporter assays. Results The 3 TNFAIP3 SNPs were not significantly associated with risk of pSS. But multivariate analysis demonstrated a significant association between the rs2230926 SNP (coding for an amino acid substitution in exon 3) and pSS complicated by lymphoma: OR vs controls = 3.36 (95%CI 1.34 - 8.42) p= 0.0097, OR vs pSS without lymphoma = 3.26 [95%CI 1.31 – 8.12], p=0.011. TNFAIP3 gene sequencing of germinal DNA from 43 patients with pSS and lymphoma confirmed the more frequent presence of the rs2230926G risk variant in 11/43 patients (25.6%, versus 11% in controls, p=0.018). Twelve of the 20 (60%) patients with paired germinal and lymphoma TNFAIP3 sequence data had functional abnormalities of A20. The frequency was even higher (77%) among pSS patients with MALT lymphoma (n=28). Mutated A20 variants (rs2230926G and GG insertion) were both less effective than the wild type A20 in inhibiting NF-kB-dependent activation (p Conclusions This study demonstrates that A20 inactivation plays a key role in lymphomagenesis in the context of autoimmunity. It supports a scenario in which the presence of germinal and/or somatic abnormalities of genes leading to impaired control of NF-kB activation in B cells continuously stimulated by autoimmunity enhances the risk of lymphoma. Disclosure of Interest None Declared
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- 2013
26. Une spondylodiscite aspergillaire nosocomiale ?
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L. Escaut, N. Dahane, A. Angoulvant, A. Blaise-Stevens, and T. Lazure
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Infectious Diseases - Published
- 2013
27. Granulomatose lymphomatoïde et leucémie LGL : une association fortuite ?
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T. Lazure, A. Duréault, G. Tercian, Martine Raphael, Jean-Marie Michot, Yassine Taoufik, and Olivier Lambotte
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Gastroenterology ,Internal Medicine - Published
- 2011
28. Une cause exceptionnelle de cytopénies : le sarcome histiocytaire
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Cécile Goujard, N. Bellon, M. Brunet, Martine Raphael, T. Lazure, Olivier Lambotte, and Gwenola Maigne
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Gastroenterology ,Internal Medicine - Published
- 2010
29. 782 Tumeur palpébrale révélant un lymphome du manteau
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I. Ssi Yan Kai, Hervé Offret, M. Dauphin, Marc Labetoulle, T. Lazure, and J. Proenca
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Ophthalmology - Abstract
Introduction Le lymphome a cellules du manteau est une entite lymphoproliferative reconnue depuis une dizaine d’annees seulement. Ce sous-type clinico-pathologique du lymphome B represente approximativement 6 % des cas de lymphomes non-Hodgkiniens. Son pronostic est relativement sombre. Materiels et Methodes Nous rapportons le cas d’un lymphome du manteau a revelation palpebrale. Observation Un homme de 62 ans a consulte pour une tumefaction de la paupiere superieure droite decouverte a la suite d’un traumatisme facial. La tumefaction etait initialement souple et mobile par rapport au plan palpebral. Cependant, elle croissait rapidement et devenait adherente. Une biopsie exerese complete de la lesion fut realisee et l’analyse anatomopathologique concluait a un lymphome du manteau. Le bilan complementaire revela une maladie etendue avec des adenopathies retro peritoneales, une splenomegalie et une phase leucemique circulante. Le patient fut inclus dans un protocole de chimiotherapie specifique. Discussion Le lymphome du manteau est une pathologie rare et sa localisation palpebrale, inhabituelle. D’apres la litterature, cette atteinte presume d’un stade avance de la maladie et traduit un caractere evolutif. Conclusion Toute tumefaction orbito-palpebrale evolutive du sujet âge doit faire evoquer une hemopathie maligne et proposer une biopsie.
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- 2008
30. Diagnostic des tumeurs stromales gastro-intestinales (GIST) : intérêt de la reclassification des tumeurs conjonctives digestives (étude ERMIT)
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A. Balaton, Geneviève Monges, P. Cervera, Jean-Yves Scoazec, Dominique Ranchère-Vince, Benoit Terris, T. Lazure, J.-M. Coindre, J. Ramos, P. Walter, M.-D. Diebold, J F Mosnier, Anne Couvelard, and C. Delattre
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Pathology and Forensic Medicine - Published
- 2006
31. Lumbar Vertebral Fracture Through a Pre-Existing Schmorl's Node Mimicking Histopathologically a Low-Grade Chondrosarcoma.
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Papavasiliou K, Lazure T, Ghaouche J, Bouthors C, and Court C
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The aim of this paper is to present a unique, to the best of our knowledge, case of a patient with a fracture of the first lumbar vertebra (L1), which occurred through a pre-existing Schmorl's node (SN), with histopathological characteristics mimicking a low-grade chondrosarcoma that initially led to a false diagnosis. A 54-year-old woman tripped and fell to the ground, sustaining a fracture of the L1 vertebral body. She was treated conservatively with gradual mobilization using a thoracolumbar brace for six weeks. Due to persistent pain and her inability to achieve full mobilization, she was offered vertebral kyphoplasty. During the same operative session and just before the kyphoplasty, she underwent a core-needle biopsy of the affected area. Following her operation, she reported a gradual, yet quick and full remission of her symptoms. The pathology report indicated findings consistent with a low to mid-grade chondrosarcoma. A re-evaluation of the specimen by a different pathologist confirmed the diagnosis of low-grade chondrosarcoma. Subsequently, she underwent full oncological staging, which was negative for metastases. Additional imaging studies failed to show signs of local disease progression. Due to the discordance between the pathology reports and the imaging and clinical findings, her case was referred to our specialized center for spinal tumor surgery. A new pathological re-evaluation of the biopsy samples was performed, and the diagnosis of low-grade chondrosarcoma was once again confirmed. However, during the multidisciplinary tumor (MDT) meeting that followed, and after careful evaluation of subsequent imaging studies that showed signs of local improvement and due to the complete lack of symptoms, the histopathological findings were re-evaluated and attributed to the fracture occurring through a pre-existing SN penetrating the cancellous bone of the vertebra. This complex situation contributed to histopathological findings consistent with a well-differentiated chondrosarcoma. The patient remains symptom-free 10 months following her operation and has fully returned to her previous activities. Our unique case highlights the importance of an MDT meeting when evaluating patients with musculoskeletal tumors and emphasizes the need for increased awareness when clinical findings and imaging studies are in discordance with histopathology reports., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Papavasiliou et al.)
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- 2024
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32. Immune Checkpoint Inhibitor-induced Sicca Syndrome.
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Bitoun S, Rousseau A, Gosset M, Belkhir R, Lazure T, Mariette X, and Nocturne G
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- Humans, Quality of Life, Immune Checkpoint Inhibitors adverse effects, Sjogren's Syndrome immunology, Sjogren's Syndrome drug therapy, Sjogren's Syndrome diagnosis
- Abstract
The development of sicca in patients treated with immune checkpoint inhibitors (ICIs) is undoubtedly an underestimated complication, but one whose functional consequences and impact on quality of life are significant for patients. This update aims to review the frequency of this complication and different clinical pictures. The authors also propose a diagnostic and therapeutic approach to guide clinicians in daily practice., Competing Interests: Disclosure The authors have nothing to disclose., (Copyright © 2024 Elsevier Inc. All rights reserved.)
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- 2024
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33. Complete remission after a single bisphosphonate infusion in isolated bone Langerhans cell histiocytosis lesion: a case report and a narrative review of the literature.
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Kachaner A, Seror R, Aubart FC, Henry J, Lazure T, Emile JF, Mariette X, and Bitoun S
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Langerhans cell histiocytosis (LCH) is a rare disease with limited treatment options. We present a case involving a 57-year-old woman afflicted with an isolated LCH bone osteolytic lesion. A single bisphosphonate infusion significantly alleviated pain, and follow-up scans via CT, PET-CT, and MRI revealed a substantial recalcification of the lesion. Conducting an extensive literature review, we identified 46 cases documenting the efficacy of bisphosphonates in the context of LCH. These findings have raised interest in bisphosphonate infusion as a simple therapeutic alternative in similar situations, with benefits in terms of bone recalcification and pain control for individuals with LCH., Competing Interests: None declared., (© The Author(s) 2024. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research.)
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- 2024
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34. Understanding a mass in the paraspinal region: an anatomical approach.
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Creze M, Ghaouche J, Missenard G, Lazure T, Cluzel G, Devilder M, Briand S, Soubeyrand M, Meyrignac O, Carlier RY, Court C, and Bouthors C
- Abstract
The paraspinal region encompasses all tissues around the spine. The regional anatomy is complex and includes the paraspinal muscles, spinal nerves, sympathetic chains, Batson's venous plexus and a rich arterial network. A wide variety of pathologies can occur in the paraspinal region, originating either from paraspinal soft tissues or the vertebral column. The most common paraspinal benign neoplasms include lipomas, fibroblastic tumours and benign peripheral nerve sheath tumours. Tumour-like masses such as haematomas, extramedullary haematopoiesis or abscesses should be considered in patients with suggestive medical histories. Malignant neoplasms are less frequent than benign processes and include liposarcomas and undifferentiated sarcomas. Secondary and primary spinal tumours may present as midline expansile soft tissue masses invading the adjacent paraspinal region. Knowledge of the anatomy of the paraspinal region is of major importance since it allows understanding of the complex locoregional tumour spread that can occur via many adipose corridors, haematogenous pathways and direct contact. Paraspinal tumours can extend into other anatomical regions, such as the retroperitoneum, pleura, posterior mediastinum, intercostal space or extradural neural axis compartment. Imaging plays a crucial role in formulating a hypothesis regarding the aetiology of the mass and tumour staging, which informs preoperative planning. Understanding the complex relationship between the different elements and the imaging features of common paraspinal masses is fundamental to achieving a correct diagnosis and adequate patient management. This review gives an overview of the anatomy of the paraspinal region and describes imaging features of the main tumours and tumour-like lesions that occur in the region., (© 2023. The Author(s).)
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- 2023
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35. Severe colitis in patients with melanoma treated with BRAF/MEK inhibitors.
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Carbonnel F, Routier E, Lazure T, Mussini C, Bellanger C, Merklen C, Bejou B, Buisson A, Amiot A, Meyer A, Dong C, and Robert C
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- Female, Humans, Male, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Mitogen-Activated Protein Kinase Kinases therapeutic use, Mutation, Neoplasm Recurrence, Local drug therapy, Protein Kinase Inhibitors adverse effects, Proto-Oncogene Proteins B-raf genetics, Proto-Oncogene Proteins B-raf therapeutic use, Melanoma drug therapy, Melanoma genetics, Skin Neoplasms drug therapy, Skin Neoplasms etiology, Skin Neoplasms pathology
- Abstract
Background and Aims: Dual blockade of BRAF and MEK kinases is a standard of care for metastatic V600E/K BRAF mutant melanoma. This study reports the first systematic description of colitis due to BRAF and MEK inhibitors., Methods: We studied consecutive patients with melanoma, treated with BRAF and MEK inhibitors, who had colitis requiring hospitalisation. Electronic files were studied; endoscopic biopsies and colectomy specimens were read centrally., Results: Between January 2021 and March 2022, nine women and one man, aged 50-90 years, were studied. Nine patients received encorafenib and binimetinib; one patient received dabrafenib and trametinib. The main symptoms were diarrhoea, haematochezia, abdominal pain and intestinal obstruction. Blood tests showed anaemia, increased CRP and low serum albumin levels in most patients. All patients had ulcerations of the right colon with (2/10) or without (8/10) stenosis of the ileocecal valve, and 4/10 patients also had ulcerations distal to the right colon. Histopathological findings were suggestive of ischaemia and mild inflammation. Nine of the 10 patients discontinued BRAF/MEK inhibitors. Drugs were reintroduced in four patients, three of whom had a severe relapse of diarrhoea. Two patients required surgery and underwent intestinal resection. One patient died of enterocolitis., Conclusion: BRAF/MEK inhibitors can induce severe colitis characterised by ulcerations of the right colon., (© 2022 John Wiley & Sons Ltd.)
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- 2023
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36. Renal involvement of lymphomas proven by kidney biopsy: report of 10 cases from a tertiary care center and comparison with the literature.
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Urbain F, Ferlicot S, Rocher L, Besson FL, Gomez L, Michot JM, Lazure T, Mariette X, Nocturne G, Lambotte O, Zaidan M, and Noel N
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- Humans, Tertiary Care Centers, Kidney pathology, Biopsy, Lymphoma, B-Cell, Marginal Zone pathology, Lymphoma, Large B-Cell, Diffuse diagnosis, Lymphoma, Large B-Cell, Diffuse pathology
- Abstract
Lymphomas localized in the kidney are a rare entity that may be challenging to diagnose. We analyzed data from 10 patients with renal involvement of lymphoma diagnosed between 2009 and 2019 on fine needle biopsy from our tertiary center, and compared these with findings of 160 cases reported in the literature. Diffuse large B-cell lymphoma was the main histology subtype (40 and 38% in our sample and in the literature, respectively), followed by low-grade B-cell lymphomas, mostly from the marginal zone (MZ). Altogether, 106 patients had urological inaugural symptoms and 64 had general symptoms. Patients with urological presentation more often had renal masses than diffuse infiltration (p < 0.001), unilateral tumors (p = 0.0036) and low-grade B-cell lymphomas (17 vs 6%, p = 0.043). In both groups, nearly one-fourth of patients had diffuse (stage IV) lymphomas. Overall survival did not differ by the presence of urological/systemic symptoms, stage or aggressive lymphoma status. Notably, 3 of 10 patients from our series had MZ lymphomas associated with primary Sjögren syndrome revealed by acute kidney injury, including one where the autoimmune disease was detected. Lymphoproliferative disorders localized in the kidney are a challenging condition that can lead to detection of aggressive or diffuse lymphomas., (© 2022. Japanese Society of Hematology.)
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- 2022
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37. Lack of association between the TNFAIP3 rs2230926 variant and rheumatoid arthritis-associated lymphoma.
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Kedra J, Seror R, Dieudé P, Constantin A, Toussirot E, Kfoury E, Masson C, Cornec D, Dubost JJ, Marguerie L, Ottaviani S, Grados F, Belkhir R, Fain O, Fautrel B, Philippe P, Piperno M, Combe B, Lambotte O, Richez C, Sellam J, Sené T, Denis G, Lequerre T, Lazure T, Mariette X, and Nocturne G
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- Genetic Predisposition to Disease, Humans, Polymorphism, Single Nucleotide, Tumor Necrosis Factor alpha-Induced Protein 3 genetics, Arthritis, Rheumatoid genetics, Lymphoma genetics
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- 2022
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38. Features of non-Hodgkin's lymphoma diagnosed in minor salivary gland biopsies from primary Sjögren's syndrome patients.
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Parreau S, Nocturne G, Mariette X, Burroni B, Lazure T, Besson FL, Régent A, Mouthon L, Terrier B, Seror R, and Le Guern V
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- Biopsy, Female, Humans, Male, Middle Aged, Salivary Glands, Minor pathology, Lymphoma, B-Cell, Marginal Zone diagnosis, Sjogren's Syndrome complications
- Abstract
Objective: To evaluate the contribution of minor salivary gland biopsy (mSGB) histology in diagnosing primary SS (pSS)-associated non-Hodgkin B-cell lymphoma (NHL)., Methods: pSS patients with mSGB at NHL diagnosis were included., Results: Among the 24 patients (92.3% female, mean age 61.3 years) with an mSGB at NHL diagnosis, 13 (54.2%) had mSGB histology-revealed NHL (mSGB+); it was the only site enabling NHL diagnosis in 10/13 (76.9%) patients. Mucosa-associated lymphoid tissue (MALT) lymphoma was found in 23/24 (95.8%) patients; 100% of mSGB+ identified MALT lymphomas. pSS and lymphoma characteristics were comparable for mSGB+ and mSGB- patients. Eight (61.5%) of the 13 mSGB+ patients and all 11 mSGB- patients were treated for lymphoma. Between diagnosis and 1 year of follow-up, the ESSDAI without the NHL item remained stable (7.4 vs 5.0; P = 0.33) for the five untreated patients, while it decreased significantly for the 19 treated patients (15.8 vs 5.1; P = 0.004)., Conclusion: For pSS patients with suspected NHL, mSGB histology enabled NHL diagnosis in half of them, MALT was found in 95.8% and all mSGB+ were MALT lymphomas, thereby avoiding more invasive biopsy. Our results suggest that mSGB should be obtained at pSS diagnosis and repeated during follow-up when NHL is suspected., (© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
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- 2022
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39. Durable response to crizotinib in metastatic angiomatoid fibrous histiocytoma with EWSR1-CREB1 fusion and ALK overexpression.
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Ngo C, Grinda T, Boilève A, Levy A, Le Pechoux C, Haddag L, Valent A, Lazure T, Briand S, Honoré C, Faron M, Mir O, Bahleda R, Verret B, and Le Cesne A
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- Crizotinib therapeutic use, Cyclic AMP Response Element-Binding Protein metabolism, Humans, Oncogene Proteins, Fusion genetics, Oncogene Proteins, Fusion metabolism, RNA-Binding Protein EWS genetics, Receptor Protein-Tyrosine Kinases, Histiocytoma, Benign Fibrous, Histiocytoma, Malignant Fibrous drug therapy, Histiocytoma, Malignant Fibrous genetics, Histiocytoma, Malignant Fibrous pathology
- Abstract
Competing Interests: Disclosure ALC: honoraria from Bayer, Pharmamar, Decipher. BV: consultancy fees from Novartis, Pfizer, Netcancer, Lilly, Fabre, Seagen, Gilead; non-financial support (travel paid) from Lilly, Novartis, Pfizer, Accord Healthcare, Amgen. AB: non-financial support (accommodation paid) from IPSEN. OM: consultancy fees from AstraZeneca, Amgen, Bayer, Blueprint Medicines, BMS, Eli-Lilly, Ipsen, Janssen, Lundbeck, MSD, Novartis, Roche, Pfizer, Servier, Vifor Pharma; honoraria from Blueprint Medicines, Roche, Pfizer, Servier; support for attending meeting and/or travel from Amgen, Roche, Pfizer, PharmaMar; stock ownership from Amgen, Amplitude Surgical, Ipsen, Transgene. AV: honoraria from AstraZeneca. All other authors have declared no conflicts of interest.
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- 2022
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40. Detection of SARS-CoV-2 in subcutaneous fat but not visceral fat, and the disruption of fat lymphocyte homeostasis in both fat tissues in the macaque.
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Olivo A, Marlin R, Lazure T, Maisonnasse P, Bossevot L, Mouanga C, Lemaitre J, Pourcher G, Benoist S, Le Grand R, Lambotte O, Dereuddre-Bosquet N, and Bourgeois C
- Subjects
- Adipose Tissue, Animals, Homeostasis, Lymphocytes, Macaca, Subcutaneous Fat metabolism, COVID-19, SARS-CoV-2
- Abstract
The well documented association between obesity and the severity of SARS-CoV-2 infection raises the question of whether adipose tissue (AT) is impacted during this infection. Using a model of SARS-CoV-2 infection in cynomolgus macaques, we detected the virus within subcutaneous AT (SCAT) but not in visceral AT (VAT) or epicardial AT on day 7 post-infection. We sought to determine the mechanisms responsible for this selective detection and observed higher levels of angiotensin-converting-enzyme-2 mRNA expression in SCAT than in VAT. Lastly, we evaluated the immunological consequences of SARS-CoV-2 infection on AT: both SCAT and VAT T cells showed a drastic reduction in CD69 expression, a standard marker of resident memory T cell in tissue, that is also involved in the migratory and metabolic properties of T cells. Our results demonstrate that in a model of mild infection, SCAT is selectively infected by SARS-CoV-2 although changes in the immune properties of AT are observed in both SCAT and VAT., (© 2022. The Author(s).)
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- 2022
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41. Management of chordoma of the sacrum and mobile spine.
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Court C, Briand S, Mir O, Le Péchoux C, Lazure T, Missenard G, and Bouthors C
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- Humans, Pelvis pathology, Sacrum surgery, Treatment Outcome, Chordoma diagnostic imaging, Chordoma surgery, Spinal Neoplasms diagnostic imaging, Spinal Neoplasms surgery
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Chordoma is a very rare, poorly known malignancy, with slow progression, mainly located in the sacrum and spine. All age groups may be affected, with a diagnostic peak in the 5th decade of life. Clinical diagnosis is often late. Histologic diagnosis is necessary, based on percutaneous biopsy. Specific markers enable diagnosis and prediction of response to novel treatments. New radiation therapy techniques can stabilize the tumor for 5 years in inoperable patients, but en-bloc resection is the most effective treatment, and should be decided on after a multidisciplinary oncology team meeting in an expert reference center. The type of resection is determined by fine analysis of invasion. According to the level of resection, the patients should be informed and prepared for the expected vesico-genito-sphincteral neurologic sequelae. In tumors not extending above S3, isolated posterior resection is possible. Above S3, a double approach is needed. Anterior release of the sacrum is performed laparoscopically or by robot; resection uses a posterior approach. Posterior wall reconstruction is performed, with an associated flap. Spinopelvic stabilization is necessary in trans-S1 resection. Total or partial sacrectomy shows high rates of complications: intraoperative blood loss, infection or mechanical issues. Neurologic sequelae depend on the level of root sacrifice. No genital-sphincteral function survives S3 root sacrifice. Patient survival depends on initial resection quality and the center's experience. Immunotherapy is an ongoing line of research., (Copyright © 2021. Published by Elsevier Masson SAS.)
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- 2022
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42. A sexually-transmitted case of ameboma without recent travel: Contribution of Entamoeba histolytica genotyping.
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Ouafdi A, Collarino R, Normand AC, Huguenin A, Touafek F, Lazure T, Boullenois H, Thellier M, and Jauréguiberry S
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- Feces, Genotype, Humans, Sexual Behavior, Travel, Amebiasis, Entamoeba histolytica genetics, Entamoebiasis diagnosis
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- 2022
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43. Lymphoma complicating rheumatoid arthritis: results from a French case-control study.
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Kedra J, Seror R, Dieudé P, Constantin A, Toussirot E, Kfoury E, Masson C, Cornec D, Dubost JJ, Marguerie L, Ottaviani S, Grados F, Belkhir R, Fain O, Goupille P, Sordet C, Fautrel B, Philippe P, Piperno M, Combe B, Lambotte O, Richez C, Sellam J, Sené T, Denis G, Lequerre T, Lazure T, Mariette X, and Nocturne G
- Subjects
- Case-Control Studies, Herpesvirus 4, Human, Humans, Male, Arthritis, Rheumatoid complications, Arthritis, Rheumatoid diagnosis, Arthritis, Rheumatoid drug therapy, Epstein-Barr Virus Infections, Lymphoma
- Abstract
Objectives: To study the characteristics of B-cell non-Hodgkin's lymphoma (NHL) or Hodgkin lymphoma complicating rheumatoid arthritis (RA) and to identify RA-related factors associated with their occurrence., Methods: A multicentre case-control study was performed in France. Cases were patients with RA fulfilling ACR-EULAR 2010 criteria in whom B-cell NHL or Hodgkin lymphoma developed after the diagnosis of RA. For each case, 2 controls were assigned at random from the ESPOIR cohort and were matched on age at lymphoma diagnosis (cases)/age at the 10-year follow-up visit in the cohort (controls). Case and control characteristics were compared to identify parameters associated with the occurrence of lymphoma., Results: 54 cases were included and matched to 108 controls. Lymphomas were mostly diffuse large B-cell lymphoma (DLBCL, n=27, 50.0%). On immunochemistry, 4 of 27 (14.8%) lymphoma cases were positive for Epstein-Barr virus. On univariate analysis, factors associated with the occurrence of lymphoma were male sex (OR 3.3, 95% CI 1.7 to 6.7), positivity for ACPA (OR 5.1, 95% CI 2.0 to 15.7) and rheumatoid factor (OR 3.9, 95% CI 1.6 to 12.2), and erosions on radiographs (OR 3.8, 95% CI 1.7 to 8.3) and DAS28 (OR 2.0, 95% CI 1.5 to 2.7), both at the time of matching. Methotrexate, TNF blockers and a number of previous biologics were not associated with the occurrence of lymphoma. On multivariable analysis, erosions and DAS28 remained significantly associated with increased risk of lymphoma., Conclusion: Lymphomas complicating RA are mostly DLBCL. Risk of lymphoma in patients with RA was increased with markers of disease activity and severity, which supports the paradigm of a continuum between autoimmunity and lymphomagenesis in RA., Competing Interests: Competing interests: PD: participation to clinical trials and punctual interventions for BMS and Roche. CM: reports outside the submitted work personal fees from AbbVie, Amgen, Eli Lilly, Novartis, Pfizer, Sanofi. PG: honoraria from AbbVie, Amgen, Biogaran, Biogen, BMS, Celgene, Chugai, Janssen, Lilly, MEDAC, MSD, Nordic Pharma, Novartis, Pfizer, Sanofi, UCB. BF: research grants from AbbVie, Lilly, MSD and Pfizer, and honoraria from AbbVie, Amgen, Biogen, BMS, Celgene, Janssen, Lilly, Medac, MSD, Mylan, NORDIC Pharma, Novartis, Pfizer, Roche, SanofiAventis, SOBI, UCB. PP: participation in clinical trials and punctual honoraria from MSD Pfizer ABBvie Sanofi Novartis Sandoz. BC: honoraria from AbbVie, BMS, Gilead, Galapagos, Janssen, Lilly, Merck, Novartis, Pfizer, RocheChugai and research grants from Novartis, Pfizer, and Roche. GN: received honorarium from Novartis, Lilly and UCB. RS: received honorarium from Pfizer, BMS and UCB. XM: received honorarium from BMS, Gilead, Pfizer, UCB., (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2021
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44. Long-term exposure to monoclonal anti-TNF is associated with an increased risk of lymphoma in BAFF-transgenic mice.
- Author
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Nocturne G, Ly B, Paoletti A, Pascaud J, Seror R, Nicco C, Mackay F, Vincent FB, Lazure T, Ferlicot S, Stimmer L, Pascal Q, Roulland S, Krzysiek R, Hacein-Bey S, Batteux F, and Mariette X
- Subjects
- Animals, Autoimmune Diseases immunology, Autoimmunity immunology, B-Lymphocytes immunology, Cell Line, Mice, Mice, Inbred C57BL, Spleen immunology, Antibodies, Monoclonal immunology, Arthritis, Rheumatoid immunology, B-Cell Activating Factor immunology, Lymphoma immunology, Mice, Transgenic immunology, Tumor Necrosis Factor Inhibitors immunology, Tumor Necrosis Factor-alpha immunology
- Abstract
The impact of treatment on the risk of lymphoma in patients with rheumatoid arthritis (RA) is unclear. Here, we aimed to assess if the risk of lymphoma differs according to the type of tumor necrosis factor inhibitor (TNFi), comparing monoclonal anti-TNF antibodies to the soluble TNF receptor. We used B cell activating factor belonging to the TNF family (BAFF)-transgenic (Tg) mice as a model of autoimmunity-associated lymphoma. Six-month-old BAFF-Tg mice were treated with TNFi for 12 months. Histological examination of the spleen, assessment of the cellular composition of the spleen by flow cytometry and assessment of B cell clonality were performed at euthanasia. Crude mortality and incidence of lymphoma were significantly higher in mice treated with monoclonal anti-TNF antibodies compared to both controls and mice treated with the soluble TNF receptor, even at a high dose. Flow cytometry analysis revealed decreased splenic macrophage infiltration in mice treated with monoclonal anti-TNF antibodies. Overall, this study demonstrates, for the first time, that a very prolonged treatment with monoclonal anti-TNF antibodies increase the risk of lymphoma in B cell-driven autoimmunity. These data suggest a closer monitoring for lymphoma development in patients suffering from B cell-driven autoimmune disease with long-term exposure to monoclonal anti-TNF antibodies., (© 2021 British Society for Immunology.)
- Published
- 2021
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45. Diagnostic Splenectomy: Characteristics, Pre-Operative Investigations, and Identified Pathologies for 20 Patients.
- Author
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Maillot J, Malfuson JV, Lazure T, Benoist S, Cremades A, Hornez E, Besson FL, Noël N, and Lambotte O
- Abstract
Splenectomy is indicated in cases of trauma to the spleen or hematological and immunological diseases (hereditary spherocytosis, autoimmune cytopenia). Less frequently, splenectomy is performed for diagnostic purposes to complement unsuccessful prior etiological investigations. The splenectomy remains a surgery at risk of complications and should be considered as a last-resort procedure to make the diagnosis and to be able to treat patients. We studied the medical files of 142 patients who underwent a splenectomy for any reason over a 10-year period and identified 20 diagnostic splenectomies. Diagnostic splenectomies were mainly performed to explore unexplained splenomegaly for 13 patients and fever of unknown origin for 10. The other patients had surgery for other causes (cytopenia, abdominal symptoms, suspicion of relapsing malignant hemopathies). Splenectomy contributed to the final diagnosis in 19 of 20 cases, corresponding mostly to lymphoid hemopathies (14/20). The most frequent disease was diffuse large B-cell lymphoma (8/20). Splenectomy did not reveal any infectious disease. The most relevant pre-operative procedures to aid the diagnosis were
18 F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and immuno-hematological examinations. Diagnostic splenectomy is useful and necessary in certain difficult diagnostic situations. Highlights: Diagnostic splenectomy is still useful in 2020 to diagnose unexplained splenomegaly or fever of unknown origin. Lymphoma was the most common final diagnosis. FDG PET/CT was the most useful tool to aid in the diagnosis.- Published
- 2021
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46. Severe ulcerative gastrointestinal toxicity following ibrutinib therapy: two case studies.
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Pacoureau L, De Menthon M, Boytchev I, Lazure T, Rocher L, Lambotte O, and Noël N
- Subjects
- Adenine analogs & derivatives, Humans, Piperidines, Pyrazoles adverse effects, Leukemia, Lymphocytic, Chronic, B-Cell, Pyrimidines adverse effects
- Published
- 2021
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47. Efficacy and safety of oral metronomic etoposide in adult patients with metastatic osteosarcoma.
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Perret A, Dômont J, Chamseddine AN, Dumont SN, Verret B, Briand S, Court C, Lazure T, Adam J, Ngo C, Even C, Levy A, Bayle A, Lucibello F, Haddag-Miliani L, Faron M, Honoré C, Le Cesne A, and Mir O
- Subjects
- Administration, Metronomic, Administration, Oral, Adult, Aged, Antineoplastic Agents, Phytogenic adverse effects, Bone Neoplasms pathology, Disease Progression, Etoposide adverse effects, Female, Humans, Male, Middle Aged, Osteosarcoma secondary, Progression-Free Survival, Retrospective Studies, Time Factors, Young Adult, Antineoplastic Agents, Phytogenic administration & dosage, Bone Neoplasms drug therapy, Etoposide administration & dosage, Osteosarcoma drug therapy
- Abstract
Therapeutic options in patients with metastatic osteosarcoma are limited and effective systemic treatments are needed in this setting. The aim of this case series was to assess the efficacy and toxicity of oral metronomic etoposide in adult patients with progressive metastatic osteosarcoma. We retrospectively reviewed the electronic records of patients treated with oral metronomic etoposide (25 mg thrice daily, 3 weeks out of 4) from December 2002 to December 2018 at Gustave Roussy (Villejuif, France). The primary endpoint was progression-free rate (PFR) at 4 months; secondary endpoints were: best response (according to RECIST v1.1), progression-free survival (PFS), overall survival (OS) and safety. With a median follow-up of 9.8 months, 37 patients were eligible for this analysis: 68% males, median age 42 (range: 21-75), 19% with synchronous metastases, 92% with lung metastases, median PS: 1 (range: 0-3). Median number of previous treatment lines in the metastatic setting was 1 (range: 0-4). Progression-free rate at 4 months was 40.3% (95% CI: 24.5-56.2). Best response was partial response in 11% and stable disease in 35% of patients (disease control rate: 46%). Median PFS was 3.1 months (95% CI: 2.5-4.7) and median OS was 9.8 months (95% CI: 5.1-12.3). Toxicity profile was acceptable, with 13% grade 3 haematological toxicities (anaemia and neutropenia), without any grade 3-4 non-haematological toxicity. In our experience, oral metronomic etoposide demonstrated effective palliation along with acceptable toxicity in patients with progressive metastatic osteosarcoma., (© 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
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- 2021
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48. What is the Prognostic Value of a Discordant Radiologic and Pathologic Response in Patients Undergoing Resection of Colorectal Liver Metastases After Preoperative Chemotherapy?
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Brouquet A, Blot C, Allard MA, Lazure T, Sebbagh M, Gayet M, Lewin M, Adam R, Penna C, Sa Cunha A, and Benoist S
- Subjects
- Antineoplastic Combined Chemotherapy Protocols therapeutic use, Hepatectomy, Humans, Prognosis, Retrospective Studies, Treatment Outcome, Colorectal Neoplasms diagnostic imaging, Colorectal Neoplasms drug therapy, Colorectal Neoplasms surgery, Liver Neoplasms diagnostic imaging, Liver Neoplasms drug therapy, Liver Neoplasms secondary, Liver Neoplasms surgery
- Abstract
Background: The clinical significance of discordant radiological and pathological response to preoperative chemotherapy of colorectal liver metastases (CLM) is unknown., Methods: From 2011 to 2016, all eligible patients undergoing resection for CLM after preoperative chemotherapy were included at two centres. Patients were categorized according to radiologic response using RECIST as Rad-responders (complete/partial response) or Rad-non responders (stable disease) and according to Blazer et al. pathologic response grade as Path-responders (complete/major response) or Path-non responders (minor response). Survival outcome was analysed according to radiologic and pathologic response., Results: Among 413 patients undergoing resection of CLM, 119 fulfilled the inclusion criteria. Among these, 52 (44%) had discordant radiologic and pathologic response including 27 Rad-non responders/path responders and 25 Rad-responders/Path-non responders. Rad-non responders/path responders and Rad-responders/Path-non responders had similar characteristics except for the proportion receiving more than 6 cycles of preoperative chemotherapy (7/27 vs 16/25; P = 0.017). Median disease-free survival was not different in patients with or without discordant radiologic and pathologic responses (P = 0.195) but the type of discordance had an impact on oncologic outcome as median disease-free survival was 13.9 months (95% CI 5.7-22.2 months) in Rad-non responders/Path responders and 8.6 (6.2 - 10.9 months) in Rad-responders/Path-non responders (P = 0.034). Univariate and multivariate analysis showed that major pathologic response was associated with improved disease-free survival (OR 0.583, 95% CI 0.36-0.95, P = 0.031)., Conclusion: A discordant radiologic and pathologic response is common after preoperative chemotherapy for CLM. In these patients, pathologic response drives oncologic outcome.
- Published
- 2020
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49. In situ BCL2 expression is an independent prognostic factor in HIV-associated DLBCL, a LYMPHOVIR cohort study.
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Philippe L, Lancar R, Laurent C, Algarte-Genin M, Chassagne-Clément C, Fabiani B, Pierre Chenard M, Lazure T, Parrens M, Charlotte F, Delattre C, Gibault L, Capron F, Goubin-Versini I, Petitjean B, Boué F, Mounier N, Costello R, Costagliola D, Prevot S, and Besson C
- Subjects
- Adult, Cyclophosphamide administration & dosage, Disease-Free Survival, Doxorubicin administration & dosage, Female, Humans, Male, Middle Aged, Prednisone administration & dosage, Rituximab administration & dosage, Survival Rate, Vincristine administration & dosage, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Gene Expression Regulation, Neoplastic, HIV Infections drug therapy, HIV Infections metabolism, HIV Infections mortality, HIV-1 metabolism, Lymphoma, Large B-Cell, Diffuse drug therapy, Lymphoma, Large B-Cell, Diffuse metabolism, Lymphoma, Large B-Cell, Diffuse mortality, Proto-Oncogene Proteins c-bcl-2 biosynthesis
- Abstract
The prognostic value of cell of origin (COO) classification and BCL2 expression is not well established in diffuse large B-cell lymphoma (DLBCL) patients with human immunodeficiency virus (HIV) infection in the recent era. Phenotypic patterns were determined by immunohistochemistry (IHC) of pathological samples from patients with HIV-associated DLBCL prospectively enrolled in the French AIDS and Viral Hepatitis CO16 Lymphovir cohort between 2008 and 2015. Molecular subgroup classification into germinal centre B-cell (GCB) and non-GCB subtypes was determined using the Hans algorithm. Among 52 samples of systemic DLBCL subjected to centralized pathological analysis, 25 of the 42 tested for BCL2 expression were positive. Samples were further classified into GCB (n = 19) and non-GCB (n = 16) subtypes and 17 remained unclassified. In multivariable analysis, BCL2 expression was an independent pejorative prognostic biomarker [4-year progression-free survival (PFS): 52% for BCL2
+ vs. 88% for BCL2- , P = 0·02] and tended to reduce 4-year overall survival (OS) (63% for BCL2+ vs. 88% for BCL2- , P = 0·06). The difference between CGB and non-GCB subtypes on PFS and OS did not reach significance (4-year PFS: 79% for GCB vs. 53% for non-GCB, P = 0·24 and 4-year OS: 78% for GCB vs. 69% for non-GCB, P = 0·34). BCL2 expression determined by IHC is an independent pejorative prognostic biomarker in HIV-associated DLBCL in the recent era. This supports the investigation of new therapeutic strategies in patients with BCL2 expression., (© 2019 British Society for Haematology and John Wiley & Sons Ltd.)- Published
- 2020
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50. IgG4-related disease: rare presentation as a soft-tissue mass in the thigh of an adolescent.
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Creze M, Boussebaa S, Lazure T, Briand S, and Court C
- Subjects
- Adolescent, Humans, Immunoglobulin G4-Related Disease surgery, Magnetic Resonance Imaging, Male, Positron Emission Tomography Computed Tomography, Soft Tissue Neoplasms surgery, Thigh, Immunoglobulin G4-Related Disease diagnostic imaging, Soft Tissue Neoplasms diagnostic imaging
- Abstract
We report a case of a 16-year-old boy who presented a soft-tissue mass in the anterior compartment of the right thigh discovered by positron emission tomography/computed tomography within the work-up of unexplained prolonged inflammatory syndrome. The mass has no calcification. Subsequently, magnetic resonance imaging of the femoral triangle was carried out. Axial short tau inversion recovery images showed a 3.5-cm ill-defined mass in the femoral triangle with focal areas of hypointensity, which suggests that there might be fibrosis or hemosiderin within the tumor. Axial T1-weighted images showed a slight hyperintense mass involving the iliopsoas muscle. Contrast-enhanced fat-suppressed T1-weighted imaging showed a heterogeneous solid enhancement. Adjacent thick fascia enhancement of the vastus intermedius and the vastus lateralis muscles extending from the mass as a tail-like margin suggested the infiltrative spread of the tumor along the fascial plane. The mass and the lymphadenopathy were excised. Immunohistochemically, tumor cells were staining for muscle actin and desmin. Many plasma cells were IgG4+ (175per high-power field) with a ratio IgG4+/IgG+ of 50%. The diagnosis of IgG4-related disease (IgG4-RD) was made. Although a diffuse array of musculoskeletal symptoms has been observed in IgG4-related disease, reports of biopsy-proven musculoskeletal involvement of the limb are rare. We showed the radiological features of IgG4-RD presenting as a soft-tissue mass of the thigh. Musculoskeletal involvement, clinical significance, and treatment of IgG4-RD are also discussed.
- Published
- 2020
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