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Accurate assessment of renal function is essential for determining serum vancomycin (VCM) concentration. Creatinine clearance (Ccr)-calculated using the Cockcroft and Gault (CG) equation-can be used to evaluate renal function for determining VCM dosage. However, Ccr-based evaluation may not be an accurate representation of the renal function in the elderly. Herein, we examine the effectiveness of estimated glomerular filtration rate (eGFR) calculated using the Berlin Initiative Study-1 (BIS1) equation, for predicting the serum VCM concentration. Herein, we retrospectively analyzed patients (aged ≥ 75 years) who had received VCM. Serum VCM concentration was predicted based on Ccr and eGFR. eGFR was calculated using the Japanese equation for eGFR (eGFR

No studies have examined the association of the combination of n-3 polyunsaturated fatty acids (PUFAs) and n-6 PUFAs intake with psychological distress during pregnancy. To examine these associations, we divided Japanese pregnant women into 25 groups based on combining quintiles of n-3 PUFAs intake and quintiles of n-6 PUFAs intake. We conducted multivariable logistic regression analyses to assess the risk of psychological distress during pregnancy (Kessler Psychological Distress Scale ≥ 5 or 13). Compared to the third quintile of both n-3 PUFAs and n-6 PUFAs intake, the groups with unbalanced intake, high intake of both, and low intake of both were associated with a higher risk of both Kessler Psychological Distress Scale ≥ 5 and 13 in early and mid-pregnancy. Further research is needed to identify the precise combination of n-3 PUFAs and n-6 PUFAs intake associated with the lowest psychological distress during pregnancy.

Supplemental Digital Content is available in the text., Major adverse cardiovascular events are closely associated with 24-hour blood pressure (BP). We determined outcome-driven thresholds for 24-hour mean arterial pressure (MAP), a BP index estimated by oscillometric devices. We assessed the association of major adverse cardiovascular events with 24-hour MAP, systolic BP (SBP), and diastolic BP (DBP) in a population-based cohort (n=11 596). Statistics included multivariable Cox regression and the generalized R2 statistic to test model fit. Baseline office and 24-hour MAP averaged 97.4 and 90.4 mm Hg. Over 13.6 years (median), 2034 major adverse cardiovascular events occurred. Twenty-four-hour MAP levels of

We investigated the temporal and spatial development of the near-Earth magnetotail during substorms based on multi-dimensional superposed-epoch analysis of Geotail data. The start time of the auroral break-up (t=0) of each substorm was determined from auroral data obtained by the Polar and IMAGE spacecraft. The key parameters derived from the plasma, magnetic-field, and electric-field data from Geotail were sorted by their meridional X(GSM)–Z(proxy) coordinates. The results show that the Poynting flux toward the plasma-sheet center starts at least 10 min before the substorm onset, and is further enhanced at X~−12 RE (Earth radii) around 4 min before the onset. Simultaneously, large-amplitude fluctuations occurred, and earthward flows in the central plasma sheet between X~−11 RE and X~−19 RE and a duskward flow around X=−10 RE were enhanced. The total pressure starts to decrease around X=−16 RE about 4 min before the onset of the substorm. After the substorm onset, a notable dipolarization is observed and tailward flows commence, characterised by southward magnetic fields in the form of a plasmoid. We confirm various observable-parameter variations based on or predicted by the relevant substorm models; however, none of these can explain our results perfectly. Therefore, we propose a catapult (slingshot) current-sheet relaxation model, in which an earthward convective flow produced by catapult current-sheet relaxation and a converted duskward flow near the Earth are enhanced through flow braking around 4 min before the substorm onset. These flows induce a ballooning instability or other instabilities, causing the observed current disruption. The formation of the magnetic neutral line is a natural consequence of the present model, because the relaxation of a highly stretched catapult current-sheet produces a very thin current at its tailward edge being surrounded by intense earthward and tailward magnetic fields which were formerly the off-equatorial lobe magnetic fields. This location is the boundary between a highly stressed catapult current sheet and a Harris-type current sheet characterized by little stress. In addition, the flows induced around the boundary toward the current-sheet center may enhance the formation of the magnetic neutral line and the efficiency of magnetic reconnection. After magnetic reconnection is induced, it plays a significant role in driving the substorm.

This paper addresses the problem of direction-of-arrival (DOA) estimation both in azimuthal and elevation angle from binaural sound that is processed with a head-related transfer function (HRTF). Previously, we proposed a weighted Wiener gain (WWG) method for two-dimensional DOA estimation with two-directional microphones. However, for signals processed with HRTFs, peaks in the spatial spectra of WWG indicating true sources can mingle with spurious peaks. To resolve this situation, we propose to apply incremental source attenuation (ISA) in combination with WWG. In fact, ISA reduces spectral components originating from specified sound sources and thereby improves the localization accuracy of the next targeted source in the proposed incremental estimation procedure. We conduct computer simulations using directional microphones and four HRTF sets corresponding to four individuals. The proposed method is compared to two DOA estimation methods that are equivalent to two generalized cross-correlation functions and two high-resolution methods of multiple signal classification (MUSIC) and minimum variance method. For comparison purposes, we introduce binary coherence detection (BCD) to high-resolution methods for emphasizing valid spectral components for localization in multiple source conditions. Evaluation results demonstrate that, although MUSIC with BCD yield comparable performance to that of WWG in conditions where single speech source exists, WWG with ISA surpasses the other methods in conditions including two or three speech sources.

To fabricate master templates of high-density patterned magnetic media, the authors developed a high-resolution and high-throughput rotary stage electron beam mastering system. They accomplished the fabrication of discrete track media groove patterns with 45nm track pitch, and also a dense bit array with both track and bit pitch of 35nm for bit patterned media under the conditions of a bit rate of 1.22MHz∕bit at 50kV acceleration voltage. The high resolution and high throughput are derived from using a continuous stage movement flyback lithography (CSFL) function. CSFL is enabled by differentiated capabilities, such as an electron optical column that achieves a large beam current at a small beam diameter, and a friction-driven slider stage that provides a highly accurate positioning capability and a dynamic focus correction feature and r-theta stage driving. The CSFL capability, working in conjunction with a blankingless beam shift lithography (BLSL), is very effective for fabricating various kinds of ser...

A 28-year-old woman who complained of irregular menstruation was diagnosed as suffering from trisomy 18 mosaicism. She was karyotyped because of her characteristic face, mild mental retardation and aberrant hyperpigmentation of the skin. Her motor function was within normal range. Physical and laboratory examinations, however, revealed obesity, short stature, minor anomalies of the fingers, many areas of hyperpigmentation on the trunk and the hips, hypergonadotropinemia, diabetes mellitus, liver dysfunction, and hyperlipidemia. The ratios of normal/trisomy 18 were 4:135 in blood lymphocytes, 3:11 in a hyperpigmented area of the skin, 20:0 in a normally pigmented area of the skin, and 14:6 in ascitic cells. Laparoscopy revealed that her ovaries contained neither follicles nor germ cells.

This paper proposes a new cost minimisation control scheme for a predenitrification type of biological wastewater treatment process and evaluates the validity of the control scheme based on the benchmark process presented by Copp. The control scheme adopting a hierarchical control structure incorporates lower-level controllers that consist of a set of local dynamic controllers and a higher-level static optimiser that provides the set points of the lower-level controllers based on the total cost index of Vanrolleghem and Gillot. Prior to benchmarking, this paper derives a simplified process model used for the optimiser, which is able to approximate the benchmark process model effectively as well as is simplified sufficiently for faster set point optimisation for on-line purposes. Numerical experiments evaluate the effectiveness of the proposed control scheme from various viewpoints including process operational and optimisation viewpoints.

Carbon stocks in the wood products pool are considered to be increasing globally. Simplified methods for estimating the fate of carbon in wood products need to be prepared to allow estimation at the national level. Since current methods cause some problems when dealing with specific countries, we try to improve the current methods. We discuss the potential carbon sequestration in wood products and the impacts of three accounting approaches (IPCC default, stock-change and atmospheric-flow) on net carbon emissions of 16 industrialized countries. We draw the following conclusions: (1) we improved the current methods for estimating the fate of carbon by considering the recycling of paper and the use of other fiber pulp, but further improvement need to be made; (2) the annual carbon sequestrations in wood products during 1990–1999 correspond to a few to 10% of 1990 base-year emissions from fossil fuels and cement production, depending on country and year. For the analyzed countries as a whole, the annual carbon sequestration was around 2%; (3) the impact of the accounting approaches on net carbon emissions at the national level is significant. Therefore, policy implications must be carefully considered when one of these approaches is adopted.

Anaplastic thyroid carcinoma is a rapidly growing, aggressive neoplasm affecting the elderly which does not respond to most of the therapies. We established cultured cell lines from four untreated tumors. The cultures grew in a monolayer of spindle-shaped cells in three cell lines and of small polygonal cells in one line, having relatively long doubling times and chromosomal abnormalities. The xenotransplantation of the lines in athymic nude mice produced tumors with a histology similar to the original tumors. The immunocytochemical staining showed the expression of PCNA, HLA-class 1, cytokeratin, vimentin and FAS (fatty acid synthase) but not CEA, desmin or P-glycoprotein. The lines secreted TPA, IL-6, IL-8 and few or no thyroid-related hormones in the culture supernatant. One cell line produced G-CSF. The chemosensitivity assay revealed intrinsic drug resistance to nine out of 11 antineoplastic agents. The reverse transcriptase-polymerase chain reaction (RT-PCR) detected MRP (multidrug resistance-associated protein) mRNA but not mdr (multidrug resistance protein)-1 and mdr-3 mRNAs. This finding indicates that the multidrug resistance of these lines is mediated by a P-glycoprotein-unrelated mechanism. The RT-PCR also presented FAS mRNA in all the lines, and IL-6 and IL-8 mRNAs in some of the lines.

Background and Objectives: The genetic background of the DVa category phenotype has been described in two Caucasian individuals. We were interested in the RHD sequence of 7 Japanese DVa individuals and their families. Materials and Methods: With SSP–PCR we tested exons 4, 5 and 7 of the RHD gene and used restriction enzymes for testing nucelotide associated with the DVa phenotype. Results: A single RHD G667 C697 allele was present in 5 individuals with DVa category phenotype, and in 2 individuals we found a D–CE–D hybrid gene (exon 5 had been replaced). The DVaCe gene complex was found in all families. Conclusion: The changes of the RHD gene described in European DVa individuals were also observed in Japanese families.

This work was designed to evaluate the toxicity of inhalable particles [less than/equal to] 10 microm in aerodynamic diameter (PM(10)) collected from the urban air in São Paulo, Brazil, to the mucociliary apparatus using the frog palate preparation. Seven groups of frog palates were immersed in different concentrations of PM(10) diluted in Ringer's solution during 120 min: 0 (control, n = 31); 50 (n = 10); 100 (n = 9); 500 (n = 28); 1,000 (n = 10); 5,000 (n = 11); and 10,000 microg/m(3) (n = 10). Mucociliary transport and transepithelial potential difference were determined at 0, 30, 60, and 120 min exposure. Additional groups (control and 500 microg/m(3)) were studied by means of morphometric analyses (quantification of the amount of intraepithelial and surface mucins), measurement of cilia beat frequency, and quantification of total glutathione. Mucociliary transport and transepithelial potential difference were significantly decreased at higher concentrations of PM(10) (p = 0.03 and p = 0.02, respectively). Exposure to PM(10) also elicited a significant decrease of total glutathione (p = 0. 003) and depletion of neutral intraepithelial mucins (p = 0.0461). These results show that PM(10) can promote significant alterations in ciliated epithelium in vitro. Images Figure 1 Figure 2

This paper describes some applications of Thermo-Calc to steel product development. Calculations of thermodynamic equilibria such as phase boundary and equilibrium precipitates have been utilized for the following R&D items: the strengthening of thin-gage steel sheets for cans, the prevention of sensitization in stainless steels, the optimization of rolling conditions for Si steels, and the decreasing in yield ratio of interstitial-free steels.

The nephric duct is the first epithelial tubule to differentiate from intermediate mesoderm that is essential for all further urogenital development. In this study we identify the domain of intermediate mesoderm that gives rise to the nephric duct and demonstrate that the surface ectoderm is required for its differentiation. Removal of the surface ectoderm resulted in decreased levels of Sim-1 and Pax-2 mRNA expression in mesenchymal nephric duct progenitors, and caused inhibition of nephric duct formation and subsequent kidney development. The surface ectoderm expresses BMP-4 and we show that it is required for the maintenance of high-level BMP-4 expression in lateral plate mesoderm. Addition of a BMP-4-coated bead to embryos lacking the surface ectoderm restored normal levels of Sim-1 and Pax-2 mRNA expression in nephric duct progenitors, nephric duct formation and the initiation of nephrogenesis. Thus, BMP-4 signaling can substitute for the surface ectoderm in supporting nephric duct morphogenesis. Collectively, these data suggest that inductive interactions between the surface ectoderm, lateral mesoderm and intermediate mesoderm are essential for nephric duct formation and the initiation of urogenital development.

Photographic devices utilizing the pyroelectric effect have already been put to practical use. A wide-range photosensor (WRP) is a detector system using the pyromagnetic effect of a low-Curie-temperature magnetic film (LMF) with 1 μm. thickness. When light is directed onto the WRP, the latter absorbs its energy, which causes a magnetization change in the WRP. This change can be read out by a magnetoresistance element and converted into a voltage. The WRP emits a pulse in response to light with a wide range of wavelengths, from visible to invisible, and its peak value depends on the light intensity. Therefore, the WRP can be used in a radio meter and magnetic light remote control, as well as for magnetic infrared communication. This paper describes the preparation of the LMF, Hie construction of the WRP, and the light response characteristics.

OBJECTIVE Adrenocortical cells change with age in both subcellular morphology and level of steroidogenesis. This study evaluates the influence of aging on hypercortisolism and clinical manifestations in patients with ACTH-independent Cushing's syndrome due to a cortisol-secreting adrenal adenoma (CS). DESIGN Restrospective study. PATIENTS Thirty-six (33 females and 3 males) with CS. 31 healthy controls were age- and sex-matched to CS patients. MEASUREMENT Patient age at diagnosis was compared to the degree of hypercortisolism and clinical manifestations. The degree of hypercortisolism was estimated using serum cortisol levels and urinary free cortisol excretion. Positive clinical manifestations were quantified using 12 symptoms and signs which resulted in a clinical score for each patient. Endogenous creatinine clearance, estimated disease duration and gender were analysed as possible factors affecting adenoma-secreated cortisol. RESULTS Patient age correlated negatively with serum cortisol level (r = -0.417, P = 0.0107, n = 36) and urinary excretion of free cortisol (r = -0.613, P = 0.0002, n = 31). Analysis of Spearman's rank correlation showed that the clinical score decreased with age (rho = -0.631, P = 0.0004, n = 33). Oedema, weakness/myopathy, hirsutism, striae and psychological changes were infrequent symptoms in the elderly. Using stepwise multiple regression analysis, we estimated the clinical score (Y) by factors of serum cortisol levels (X1:nmol/l), age (X2: years of age) and gender (X3: gender; female = 1, male = 0), i.e. Y = 4.771 + 0.004 X1 - 0.064 X2 + 2.548 X3 (r = 0.743, P < 0.0001, n = 33). Results suggested that aging both suppressed cortisol secretion and repressed manifestations directly as an independent factor, although its direct effect may be weak. CONCLUSIONS Our findings indicated the importance of age as a factor modulating hormonal levels and possible clinical manifestations in patients with cortisol-secreting adenomas.

Interleukin-6 (IL-6), a pleiotropic cytokine, is postulated to be involved in the pathogenesis of sick euthyroid syndrome, although the direct in vitro effects of IL-6 on human thyroid function are controversial. Because IL-6 signal can be transduced when the complex of IL-6 and soluble IL-6 receptor (sIL-6R) binds to gp 130, an IL-6 signal transducer, we studied the effects of IL-6 and sIL-6R on thyroid function, using human thyroid follicles obtained from patients with Graves' disease. IL-6 alone had no inhibitory effect on TSH-induced thyroid function (125I incorporation and organic 125I release), even at supraphysiological concentrations. However, in the presence of physiological concentrations of sIL-6R (100 ng/ml), IL-6 inhibited thyroid function dose dependently and completely, accompanied with the decreased ratio of 125I-T3/125I-T4 not only in the thyroid follicles but also in the culture medium. Thyroid follicles did not secrete sIL-6R but produced IL-6 constitutively. Consistent with these findings, sIL-6R inhibited thyroid function slightly at high concentrations. Furthermore, RT-PCR analyses revealed that human thyroid follicles expressed the messenger RNAs for IL-6 and gp130 but scarcely messenger RNA for IL-6R. These in vitro findings suggest that IL-6 alone hardly affects thyroid function in thyroid follicles in which IL-6R gene is scarcely expressed. However, because sIL-6R is present abundantly in serum, IL-6 in vivo would be capable of inhibiting the synthesis and release of T4 and, to a greater extent, T3 from the thyroid gland. These in vitro findings are at least partly related to the development of sick euthyroid syndrome.

A numerical study was conducted to analyze the dissolution process of manganese sulfide, and the advantages of very-high-temperature and short-time slab reheating prior to hot rolling were demonstrated. Inhibitor dissolution was greatly accelerated at elevated temperatures. High-temperature and short-time slab reheating also facilitated structure refinement by static recrystallization with appropriate rolling schedules and reduced initial grain sizes. This recrystallization also served to improve product surface quality. Another advantage of the high-temperature hot-rolling process is increased flexibility for controlling inhibitor precipitation during hot rolling.

Experimental results of model speciments in which FRP rods fractured due to local deformation at a crack intersection in a concrete member were analyzed by a 3D nonlinear finite element method in which orthogonal anisotropy of the FRP rod was considered. The analytical results indicated that accurate prediction of shear modulus of the FRP rod and size of concrete wedge cone failure around the FRP rod was significant to predict deformation and fracture of the FRP rod. FRP rods as reinforcement in concrete members, the small shear modulus, because of the orthogonal anisotropy and the wedge cone failure, may prevent the FRP rod from fracturing at a very low tensile stress due to the local deformation at the crack intersection.

The syntheses and the antiviral activities of 2-halo derivatives of neplanocin A (1b,c), (6'R)-6'-C-methylneplanocin A (2b), and dehydroxymethylneplanocin A (3b,c) are described. SN2 reaction of the known cyclopentenyl units 12 and 13 with 2-haloadenines under basic conditions gave the protected carbocyclic nucleosides 14b,c and 15b,c, respectively. Starting from the cyclopentenone derivative 5, the optically active tosyloxycyclopentene derivative 11 was prepared, which was similarly condensed with 2-fluoroadenine to give the protected (6'R)-6'-C-methyl derivative 16b. Deprotection of these compounds afforded the target 2-halo derivatives of neplanocin A. Of these new compounds, 2-fluoroneplanocin A (1b) showed an antiviral potency and a spectrum that was comparable to that of neplanocin A (1a). It was particularly active against vaccinia virus, vesicular stomatitis virus, parainfluenza virus, reovirus, arenaviruses (Junin, Tacaribe), and human cytomegalovirus, i.e., those viruses that fall within the purview of the S-adenosyl-L-homocysteine hydrolase inhibitors.

Recrystallization kinetics of 3 % Si steel after hot rolling in the temperatures between 1373 and 1573 K, which is quite important to obtain uniform magnetic properties, was studied. Recrystallization rate after hot rolling was relatively slow because of low dislocation density, which resulted from rapid recovery, and its behavior was strongly influenced by the initial grain size and coexistence of the γphase. Based on these Findings, controlling technology of recrystallization during hot rolling of grain-oriented Si steels is discussed.

In Japan three types of rail brake were tested in the field. They were the eddy current rail brake, the electromagnetic rail brake, and the hybrid rail brake. The eddy current type, which does not come into contact with rails, needs high current and greatly increases the temperature in rails. The electromagnetic type which attracts rails and achieves braking by frictional force cannot generate a stable braking force. Therefore the authors developed a hybrid rail brake, which has advantages over the other two types. This type does not need as much current, and keeps rail temperature low.

Pneumatic microactuators such as balloon actuator and piston-cylinder actuator are highly esteemed by their high force densities. This paper proposes serially connected miniaturized micropistons with the aim of both force accumulation and multiarticular structure. Proposed flexible link of micropistons is designed to overcome the drawback of rigid wire-driven mechanism widely used for endoscope. Segmentaized multiarticular structure is flexible so as to be worn around the body of endoscope. Proposed design allows equipping pistons at the head of the body as local actuators. Local actuators can minimize transmission loss. Serially connected miniaturized pistons (22 mm × 10 mm × 0.9 mm) fabricated by electro discharge machining could successfully accumulate individual force (typically 15 mN at 500 kPa). A micropiston fabricated by Si-micromachining was also designed and demonstrated for further flexible structure.

A 3.3-V 512-k/spl times/18-b/spl times/2-bank synchronous DRAM (SDRAM) has been developed using a novel 3-stage-pipelined architecture. The address-access path which is usually designed by analog means is digitized, separated into three stages by latch circuits at the column switch and data-out buffer. Since this architecture requires no additional read/write bus and data amp, it minimizes an increase in die size. Using the standardized GTL interface, a 250-Mbyte/s synchronous DRAM with die size of 113.7-mm/sup 2/, which is the same die size as the conventional DRAM, has been achieved with 0.50-/spl mu/m CMOS process technology. >

In the fission yeast Schizosaccharomyces pombe, the cdc10+/SWI family members constitute the cell cycle 'start' genes. res1+ and res2+ are the newly identified members of this family and encode putative association partners of the Cdc10 protein. The Pat1 kinase plays a pivotal role in switching between vegetative growth and sexual development, and its inactivation in haploid cells induces unconditional growth arrest and subsequent meiosis. We have identified as an extragenic suppressor of a temperature sensitive pat1-114 mutant, a new B-type cyclin that negatively regulates conjugation by interacting with these 'start' genes. This cyclin, named Cyc17, is highly homologous with Cdc13, but has no detectable activity as a mitotic cyclin. Deletion of cyc17+ markedly enhances conjugation, despite the presence of nitrogen source, and accelerates growth arrest in G1 upon nitrogen starvation. Conversely, overexpression of the cyc17+ gene strongly inhibits conjugation. The cyc17+ gene is transcribed into 3.2 kb poly(A)+ and 3.0 kb poly(A)- RNAs. Only the poly(A)+ species is expressed during vegetative growth and periodically with a peak in the G1 and S phases of the cell cycle. On the other hand, the poly(A)- transcript is highly induced during conjugation. This induction is lost in res2- cells, whereas the poly(A)+ transcript is significantly reduced in res1- cells. However, the mating inhibition as well as the ability to rescue the pat1 mutation by overexpression of res1+ and res2+ are totally abolished in cyc17- cells. Thus, in S.pombe, a B-type cyclin, regulated by the newly identified cell cycle 'start' genes, plays a crucial role in the control of sexual development.

The concentrations of sCD4 and sCD8 in 69 patients with systemic sclerosis (SSc) were examined by using a sandwich enzyme-linked immunosorbent assay. The patients with SSc had significantly higher concentrations of sCD8 (mean 249.2 U/ml (SD 155.1), median 224 U/ml) than the normal subjects (mean 149.3 U/ml (SD 42.1), median 148 U/ml). The concentration of sCD4 in patients with SSc were significantly lower (mean 6.2 U/ml (SD 3.8), median 5.0 U/ml) than in the normal subjects (mean 10.9 U/ml (SD 4.1), median 10.3 U/ml). The concentration of sCD8 in patients with diffuse sclerosis tended to be higher than in those with sclerodactyly.

The mechanism of the significant effect of antimony additions on texture improvement was studied, and the results are as follows. When grain size before cold rolling was small, the antimony addition retarded {111} texture formation in the grain growth stage. When grain size before rolling was large, the {110} component increased in the early stage of recrystallization in the antimony-containing specimens because of the dense formation of deformation bands. Based on these effects of antimony additions on preferential texture formation, high-permeability nonoriented electrical steel has been produced at Kawasaki Steel Corporation.

Grain-oriented electrical steels have been widely used for various products, and hence, improving their properties is greatly desired to thus save electricity. Magnetic properties of grain-oriented 3% Si steels have been steadily improved since Goss invented this steel. The authors are convinced that the possibility of further improvement still exists. An important metallurgical basis for producing grain-oriented Si steel is controlling the primary recrystallization texture and the dispersion of inhibitors. Mechanisms of secondary recrystallization and the influence of primary texture on it have been discussed by Harase et al. It is well known that the inhibitor plays its role at the secondary recrystallization stage. Three important metallurgical factors related to the inhibitor exist in the process: dissolution, precipitation, and Ostwald ripening. The most important of these processes is precipitation, which is achieved primarily during hot rolling and comprises a cooling process and a deformation process. The purpose of this article is to clarify the metallurgical sequence of precipitation during hot rolling and then to improve the process by the application of this information to obtain improved magnetic properties.