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343 results on '"TAFFURELLI, GIOVANNI"'

1. Predictors of Recurrence After Curative Surgery for Stage I Colon Cancer: Retrospective Cohort Analysis of the Italian Society of Surgical Oncology Colorectal Cancer Network Collaborative Group

Author

Turri, Giulia, Martinelli, Luigi, Rega, Daniela, Tamini, Nicolò, Paiano, Lucia, Deidda, Simona, Bao, QuocRiccardo, Lorenzon, Laura, De Luca, Raffaele, Foppa, Caterina, Mari, Valentina, Taffurelli, Giovanni, Picciariello, Arcangelo, Marsanic, Patrizia, Siragusa, Leandro, Bagolini, Francesco, Nascimbeni, Riccardo, Rizzo, Gianluca, Vertaldi, Sara, Zuolo, Michele, Bianchi, Giorgio, Rorato, Lisa Marie, Reddavid, Rossella, Gallo, Gaetano, Crepaz, Lorenzo, Di Leo, Alberto, Trompetto, Mario, Potenza, Enrico, Santarelli, Mauro, de’Angelis, Nicola, Ciarleglio, Francesco, Milone, Marco, Coco, Claudio, Tiberio, Guido Alberto, Anania, Gabriele, Sica, Giuseppe S., Muratore, Andrea, Altomare, Donato Francesco, Montroni, Isacco, De Luca, Maurizio, Spinelli, Antonino, Simone, Michele, Persiani, Roberto, Spolverato, Gaya, Restivo, Angelo, de Manzini, Nicolò, Braga, Marco, Delrio, Paolo, Verlato, Giuseppe, Pedrazzani, Corrado, Gioia, Adriana, Vacca, Cristina, Parini, Dario, Tomasicchio, Giovanni, Calabrò, Marcello, Sensi, Bruno, Misuriello, Filomena, Schena, Carlo Alberto, and Picotto, Silvia

Published
2024
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5. Unveiling the intrinsic role of malnutrition in patients with Crohn's disease undergoing major surgery using entropy balancing weighting analysis.

Author

Taffurelli, Giovanni, Montroni, Isacco, Ghignone, Federico, Zattoni, Davide, Mazzotti, Federico, Frascaroli, Giacomo, and Ugolini, Giampaolo

Subjects
MALNUTRITION, CROHN'S disease, NUTRITIONAL assessment, RETROSPECTIVE studies, DESCRIPTIVE statistics, SURGICAL complications, LONGITUDINAL method, ODDS ratio, CONFIDENCE intervals, COMPARATIVE studies, DISEASE risk factors, DISEASE complications
Abstract

The negative role of malnutrition in patients with Crohn's disease is known; however, many coexisting disease-related factors could cause misinterpretation of the real culprit. This study aimed to describe the role of malnutrition using a novel methodology, entropy balancing. This was a retrospective analysis of consecutive patients undergoing elective major surgery for Crohn's disease, preoperatively screened following the European Society for Clinical Nutrition guidelines. Two-step entropy balancing was applied to the group of malnourished patients to obtain an equal cohort having a null or low risk of malnutrition. The first reweighting homogenised the cohorts for non-modifiable confounding factors. The second reweighting matched the two groups for modifiable nutritional factors, assuming successful treatment of malnutrition. The entropy balancing was evaluated using the d -value. Postoperative results are reported as mean difference or OR, with a 95 % CI. Of the 183 patients, 69 (37·7 %) were at moderate/high risk for malnutrition. The malnourished patients had lower BMI (d = 1·000), Hb (d = 0·715), serum albumin (d = 0·981), a higher lymphocyte count (d = 0·124), Charlson Comorbidity Index (d = 0·257), American Society of Anaesthesiologists (d = 0·327) and Harvey-Bradshaw scores (d = 0·696). Protective loop ileostomy was more frequently performed (d = 0·648) in the malnourished group. After the first reweighting, malnourished patients experienced a prolonged length of stay (mean difference = 1·9; 0·11, 3·71, days), higher overall complication rate (OR 4·42; 1·39, 13·97) and higher comprehensive complication index score (mean difference = 8·9; 2·2 15·7). After the second reweighting, the postoperative course of the two groups was comparable. Entropy balancing showed the independent role of preoperative malnutrition and the possible advantages obtainable from a pre-habilitation programme in Crohn's disease patients awaiting surgery. [ABSTRACT FROM AUTHOR]

Published
2024
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7. GOSAFE - Geriatric Oncology Surgical Assessment and Functional rEcovery after Surgery: early analysis on 977 patients

Author

Garutti, Anna, Taffurelli, Giovanni, Zattoni, Davide, Tramelli, Paola, Sermonesi, Giacomo, Di Candido, Francesca, Carvello, Michele, Sacchi, Matteo, De Lucia, Francesca, Foppa, Caterina, Plas, Matthijs, Van der Wal-Huisman, Hanneke, Tauceri, Francesca, Perenze, Barbara, Di Pietrantonio, Daniela, Mirarchi, Mariateresa, Fejka, Michael, Bleier, Joshua I.S., Frain, Laura, Fox, Sam W., Cardin, Kristin, De Leon, Luis E., Baltatzis, Minas, Chan, Anthony K.C., Siriwardena, Ajith K., Vertogen, Bernadette, Nanni, Oriana, Garulli, Gianluca, Alagna, Vincenzo, Pirrera, Basilio, Lucchi, Andrea, Monari, Francesco, Conti, Luigi, Capelli, Patrizio, Romboli, Andrea, Palmieri, Gerardo, Banchini, Filippo, Marano, Luigi, Spaziani, Alessandro, Castagnoli, Giampaolo, Bartoli, Alberto, Trompetto, Mario, Gallo, Gaetano, Luc, Alberto Realis, Clerico, Giuseppe, Sammarco, Giuseppe, De Luca, Raffaele, Barile, Graziana, Simone, Michele, Costanzi, Andrea, Mari, Giulio, Maggioni, Dario, Pellegrino, Roberta, Riggio, Valentina, Kenig, Jakub, Szabat, Kinga, Scabini, Stefano, Pertile, Davide, Stratta, Emanuela, Massobrio, Andrea, Soriero, Domenico, Nesbakken, Arild, Lønn, Mariann, Backe, Ingeborg Flåten, Ferrari, Giovanni, Mazzola, Michele, Alampi, Bruno D.A., Achilli, Pietro, Sfondrini, Stefano, Ioannidis, Orestis, Loutzidou, Lydia, Galanos-Demiris, Konstantinos, Pellino, Gianluca, Balducci, Genoveffa, Frezza, Barbara, Lucarini, Alessio, Santos, Claudia, Cooper, Lisa, Siam, Baha, Levy, Yochai, Brenner, Baruch, Kashtan, Hanoch, Belgrano, Valerio, De Cian, Franco, Palermo, Beatrice, Eggenhöffner, Roberto, Albertelli, Manuela, Sánchez-Guillén, Luis, Arroyo, Antonio, López-Rodríguez, Francisco, Lario, Sandra, Lillo, Cristina, Wexner, Steven D., Montroni, Isacco, Rostoft, Siri, Spinelli, Antonino, Van Leeuwen, Barbara L., Ercolani, Giorgio, Saur, Nicole M., Jaklitsch, Michael T., Somasundar, Ponnandai S., de Liguori Carino, Nicola, Ghignone, Federico, Foca, Flavia, Zingaretti, Chiara, Audisio, Riccardo A., and Ugolini, Giampaolo

Published
2020
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9. Pre-emptive Laparoscopic Colostomy Creation in Obstructing Locally Advanced Rectal and Anal Cancer Does Not Delay the Starting of Oncological Treatments.

Author

Taffurelli, Giovanni, Montroni, Isacco, Dileo, Claudia, Boccaccino, Alessandra, Ghignone, Federico, Zattoni, Davide, Frascaroli, Giacomo, and Ugolini, Giampaolo

Subjects
*MALNUTRITION, *LAPAROSCOPIC surgery, *TREATMENT effectiveness, *CANCER patients, *RETROSPECTIVE studies, *DESCRIPTIVE statistics, *MULTIVARIATE analysis, *COLOSTOMY, *COMBINED modality therapy, *MEDICAL records, *ACQUISITION of data, *ANAL tumors, *COMPARATIVE studies, *LENGTH of stay in hospitals, *BOWEL obstructions, *REGRESSION analysis, PREVENTION of surgical complications, RECTUM tumors
Abstract

Simple Summary: We conducted an evaluation of the outcomes associated with pre-emptive laparoscopic colostomy in patients suffering from obstructing rectal and anal cancer. Our findings reveal that this surgical approach has a role in facilitating the timely initiation of therapy, without causing significant delays. The ability to start treatment promptly is particularly important for these patients, as they often face advanced stages of disease and significant nutritional challenges. Our study supports the viability of this surgical method as an effective strategy for managing obstructing cancers, ensuring that patients receive the necessary treatment as quickly as possible. By addressing the obstruction early, this approach not only improves patient outcomes but also enhances their overall quality of care during a critical time. Background: Managing patients with obstructing rectal cancer is challenging due to the risks of gastrointestinal obstruction and perforation. This study evaluates the outcomes of pre-emptive laparoscopic colostomy creation in patients with locally advanced rectal and anal cancer to prevent symptoms and facilitate therapy initiation. Methods: This retrospective cohort study includes patients with locally advanced rectal or anal cancer assessed by our Colorectal Multidisciplinary Team from January 2017 to February 2024. Patients who underwent pre-emptive laparoscopic colostomy were compared to a control group of non-obstructing rectal cancer patients who started direct oncological treatment. The primary endpoint was the time from diagnosis to the initiation of oncological treatments. The secondary endpoints were the rate and timing of subsequent radical resection, surgical morbidity and hospital stay. A Weibull regression was used to evaluate the time differences between the groups. Results: There were 37 patients who received pre-emptive laparoscopic colostomy, compared to 207 control patients. The mean time from diagnosis to the start of neoadjuvant therapy was 38.3 ± 2.3 days. Despite higher rates of malnutrition and more advanced stages in the colostomy group, no significant differences were observed in the time to start therapy (p = 0.083) or time to radical resection (p = 0.187) between the groups. The laparoscopic procedure showed low rates of postoperative complications and acceptable lengths of stay. Discussion and Conclusions: Pre-emptive laparoscopic colostomy is a feasible approach for managing obstructing rectal or anal cancer. Treatment timelines were not extended compared to timelines for non-obstructing cases, despite differences in nutritional status and staging. Further prospective studies with larger cohorts are needed to validate these findings and refine treatment protocols for obstructing gastrointestinal malignancies. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Colorectal Cancer Stage at Diagnosis Before vs During the COVID-19 Pandemic in Italy

Author

Rottoli, Matteo, Gori, Alice, Pellino, Gianluca, Flacco, Maria Elena, Martellucci, Cecilia, Spinelli, Antonino, Poggioli, Gilberto, Romano, Angela, Belvedere, Angela, Lanci Lanci, Antonio, Parlanti, Daniele, Vago, Gabriele, Pezzuto, Paola, Canavese, Anna, Dajti, Gerti, Cardelli, Stefano, Catalioto, Caterina, Russo, Iris S, Violante, Tommaso, Morezzi, Daniele, Maurino, Ludovica, Filippone, Eleonora, Cuicchi, Dajana, Bernante, Paolo, Jovine, Elio, Lombardi, Raffaele, Masetti, Michele, Cipressi, Chiara, Offi, Maria F, Larotonda, Cristina, Puglisi, Silvana B, Barbosa, Augusto, Vaiana, Roberto, Bianchi, Paolo M, Tonti, Carlo, Codignola, Claudio, Zorcolo, Luigi, Restivo, Angelo, Deidda, Simona, Marchetti, Marcello E, Ippolito, Luca, Spolverato, Gaya, Pucciarelli, Salvatore, Marchegiani, Francesco, Ghio, Giacomo, Zagolin, Gaya, Glavas, Dajana, Tomassi, Monica, Rosati, Riccardo, Elmore, Ugo, Gozzini, Lorenzo, Calef, Riccardo, Puccetti, Francesco, Cossu, Andrea, Vignali, Andrea, Morino, Mario, Allaix, Marco E, Cannata, Gaspare, Lombardi, Erica, Ammirati, Carlo A, Piceni, Chiara, Buccianti, Piero, Balestri, Riccardo, Puccini, Marco, Pezzati, Daniele, d'Ischia, Roberto, Asta, Vito F, Sargenti, Benedetta, Taddei, Giacomo, Bonari, Federica, Boni, Giulia, Ferrero, Alessandro, Mineccia, Michela, Gonella, Federica, Palisi, Marco, Danese, Francesco, Cherubini, Valeria, Perotti, Serena, Carvello, Michele, Carbone, Fabio, Luberto, Antonio, Calafiore, Eleonora, De Lucia, Francesca, Sacchi, Matteo, Sasia, Diego, Giuffrida, Maria C, Ballauri, Edoardo, Cardile, Mathieu, Armentano, Serena, Beltrami, Elsa, Preve, Gabriele, Vercellone, Barbara, Mozzon, Marta, Folliero, Cristina, Lirusso, Chiara, Vecchiato, Massimo, Ziccarelli, Antonio, Gattesco, Davide, Moretti, Luisa, Crestale, Sara, Banchini, Filippo, Capelli, Patrizio, Romboli, Andrea, Palmieri, Gerardo, Conti, Luigi, Rizzi, Nicholas, Bonfili, Deborah, de Manzini, Nicolò, Germani, Paola, Osenda, Edoardo, Cortinovis, Sara, Giunta, Carlotta, Fracon, Stefano, Abdallah, Hussein, Bogoni, Selene, Portolani, Nazario, Nascimbeni, Riccardo, Molfino, Sarah, Tiberio, Guido A M, Garosio, Ilenia, Lamperti, Giulia, Rigosa, Diego, Ercolani, Giorgio, Solaini, Leonardo, Cavaliere, Davide, Avanzolini, Andrea, D'Acapito, Fabrizio, Chiarella, Leonardo L, Di Pietrantonio, Daniela, Annunziata, Domenico, Piccolo, Roberta, Sorrentino, Mario, Pansini, Mauro, Cojutti, Alessandro, Graziano, Michele, Callegari, Francesco, Balzarotti, Laura, Dameno, Vitale R, Cattaneo, Antonio, Santolamazza, Giuliano, Altieri, Caterina, Magarini, Riccardo, Pietrabissa, Andrea, Dominioni, Tommaso, Pugliese, Luigi, Peri, Andrea, Botti, Marta, Salvetti, Francesco, Cassinotti, Elisa, Baldari, Ludovica, Boni, Luigi, Messina, Valentina, D'Abrosca, Vera, Cianci, Pasquale, Tumolo, Rocco, Gattulli, Domenico, Restini, Enrico, Minafra, Marina, Sederino, Maria G, Bottalico, Bernardino, Pilati, Pierluigi, Franzato, Boris, Mattara, Genny, De Simoni, Ottavia, Barina, Andrea, Tonello, Marco, Muratore, Andrea, Calabrò, Marcello, Federico Pipitone, Nicoletta S, Cuzzola, Bruno, Herranz van Nood, Elena, Passuello, Nicola, Frasson, Alvise, Mammano, Enzo, Faccio, Luca, Vittadello, Fabrizio, Bressan, Alice, Sarzo, Giacomo, Tamini, Nicolò, Oldani, Massimo, Cigagna, Luca, Carissimi, Francesca, De Carlo, Giulia, Baccalini, Edoardo, Nespoli, Luca, Giordano, Alessio, Cantafio, Stefano, Grifoni, Lucrezia, Matani, Davide, Livi, Serena, Delogu, Daniele, Scognamillo, Fabrizio, Marrosu, Antonio, Guerrini, Luca, Ugolini, Giampaolo, Ghignone, Federico, Frascaroli, Giacomo, Albertini, Nicola, Zattoni, Davide, Taffurelli, Giovanni, Montroni, Isacco, Colombo, Francesco, Danelli, Piergiorgio, Bondurri, Andrea, Maffioli, Anna, Bonomi, Alessandro, Pezzoli, Isabella, Cammarata, Francesco, Goletti, Orlando, Molteni, Mattia, Assisi, Alberto, Quartierini, Giorgio, Da Lio, Corrado, Verdi, Daunia, Mondi, Isabella, Peluso, Claudia, Macchi, Lorenzo, Tanzanu, Marta, Zanzi, Federico, Pellegrini, Sara, Andreuccetti, Jacopo, D'Alessio, Rossella, Pignata, Giusto, De Capua, Michele, Canfora, Ilaria, Ottaviani, Luca, Lepiane, Pasquale, Balla, Andrea, De Carlo, Antonio, Saraceno, Federica, Scaramuzzo, Rosa, Guida, Anna, Aguzzi, Daniele, Bellora, Paolo, Gentilli, Sergio, Monni, Manuela, Nikaj, Herald, Cillara, Nicola, Cannavera, Alessandro, Deserra, Antonello, Margiani, Carla, Cabula, Roberta, Dettori, Manuela, Gramignano, Giulia, Lezoche, Giovanni, Ortenzi, Monica, Orlandoni, Elena S, Curzi, Federica, Vitali, Francesca, Capomagi, Perla, Palmieri, Miriam, Giuffrida, Mario, Del Rio, Paolo, Bonati, Elena, Loderer, Tommaso, Cozzani, Federico, Rossini, Matteo, Agnesi, Stefano, Capolupo, Gabriella T, Caricato, Marco, Carannante, Filippo, Mascianà, Gianluca, Marrelli, Martina, Miacci, Valentina, Lauricella, Sara, Tonini, Valeria, Cervellera, Maurizio, Pisconti, Salvatore, Lozito, Concetta, Shahu, Juliana, Mongelli, Claudia, Morelli, Giulia, Sartarelli, Lodovico, Sica, Giuseppe S, Siragusa, Leandro, Bagaglini, Giulia, Sensi, Bruno, Guida, Andrea M, Franceschilli, Marzia, Vinci, Danilo, Taddei, Antonio, Risaliti, Matteo, Bartolini, Ilenia, Ringressi, Maria N, Tirloni, Luca, Laface, Letizia, Abate, Emmanuele, Casati, Massimiliano, Gobbi, Pietro, Opocher, Enrico, Mariani, Nicolò M, Pisani Ceretti, Andrea, Giovenzana, Marco, Giuliani, Beatrice, Sironi, Martina, Grossi, Ugo, Zanus, Giacomo, Aniello Santoro, Giulio, Brizzolari, Marco, De Leo, Eugenio, Novello, Simone, Aquilino, Krizia, Milardi, Francesco, Olmi, Stefano, Uccelli, Matteo, Bonaldi, Marta, Cesana, Giovanni C, Bindi, Marco, Galleano, Raffaele, Langone, Antonio, Botto, Massimiliano, Franceschi, Angelo, Gambino, Elena, Ronconi, Maurizio, Casiraghi, Silvia, Casole, Giovanni, Ciulla, Salvatore L, Terrosu, Giovanni, Calandra, Sergio, Scarpa, Edoardo, Cherchi, Vittorio, Calini, Giacomo, Martinuzzo, Lisa, Clocchiatti, Lucrezia, Muschitiello, Davide, Romanzi, Andrea, Vignati, Barbara, Vannelli, Alberto, Scolaro, Roberta, Milanesi, Maria, Rossi, Fabrizio, Canonico, Giuseppe, Anastasi, Alessandro, Nelli, Tommaso, Barlettai, Marco, Fratarcangeli, Riccardo, Di Martino, Carmela, Damigella, Andrea, Adinolfi, Elvira, Birindelli, Arianna, Taglietti, Lucio, Dester, Sara E, Fleres, Francesco, Cucinotta, Eugenio, Viscosi, Francesca, Biondo Santino, Antonio, Badessi, Giorgio, Catarsini, Nivia, Mazzeo, Carmelo, Rega, Daniela, Delrio, Paolo, Cervone, Carmela, Aversano, Alessia, De Franciscis, Silvia, Di Marzo, Massimiliano, Marra, Bruno, Pace, Ugo, Amato, Antonio, Batistotti, Paola, Mina, Elisa, Serventi, Alberto, Lapolla, Pierfrancesco, Mingoli, Andrea, Sapienza, Paolo, Brachini, Gioia, Cirillo, Bruno, Fiori, Enrico, Crocetti, Daniele, Clementi, Ilaria, Martines, Gennaro, Picciariello, Arcangelo, Tomasicchio, Giovanni, Dibra, Rigers, Trigiante, Giuseppe, Rinaldi, Marcella, Lantone, Giuliano, Porcu, Alberto, Perra, Teresa, Scanu, Antonio M, Feo, Claudio F, Fancellu, Alessandro, Cossu, Maria L, Ginesu, Giorgio C, Patriti, Alberto, Coletta, Diego, Petrelli, Filippo, Greco, Paola A, Spadoni, Claudia, Cassiani, Giovanna, Bianchini, Federica, Arganini, Marco, Bianchini, Matteo, Perotti, Bruno, Palmeri, Matteo, Scabini, Stefano, Deiana, Selene, Carganico, Giacomo, Pertile, Davide, Soriero, Domenico, Fioravanti, Emanuela, Sperotto, Beatrice, Nardo, Bruno, Paglione, Daniele, Crocco, Veronica, Doni, Marco, Osso, Mariasara, Perri, Roberto, Sampietro, Gianluca M, Corbellini, Carlo, Lorusso, Leonardo, Manzo, Carlo A, Cigognini, Maria, Baldi, Caterina, Palomba, Giuseppe, Aprea, Giovanni, Capuano, Marianna, Basile, Raffaele, Tutino, Roberta, Massani, Marco, Marinelli, Laura, Canitano, Nicola, Pilia, Tiziana, Podda, Mauro, Pisanu, Adolfo, Murzi, Valentina, Incani, Silvia, Frongia, Federica, Esposito, Giuseppe, Luglio, Gaetano, Tropeano, Francesca P, Pagano, Gianluca, Spina, Eduardo, De Simone, Giuseppe, Cricrì, Michele, Catena, Fausto, Vallicelli, Carlo, Zanini, Nicola, Ronconi, Diana, Favi, Francesco, Mazzucchelli, Carlo, Convertini, Girolamo, Vincenti, Leonardo, Andriola, Valeria, Bizzoca, Cinzia, Feo, Carlo V, Fabbri, Nicolò, Fazzin, Marta, Pesce, Antonio, Gennari, Silvia, Torchiaro, Marco, Severi, Silvia, Frontali, Alice, Bracchetti, Greta, Granieri, Stefano, Cotsoglou, Christian, Carlini, Massimo, Lisi, Giorgio, Spoletini, Domenico, Mastrangeli, Maria R, Campanelli, Michela, Manigrasso, Michele, Milone, Marco, De Palma, Giovanni D, Vertaldi, Sara, Chini, Alessia, Maione, Francesco, Marello, Alessandra, Selvaggi, Francesco, Sciaudone, Guido, Selvaggi, Lucio, Menegon Tasselli, Francesco, Fuschillo, Giacomo, Oddis, Lidia, Grande, Simona, Grande, Michele, Ascanelli, Simona, Chimisso, Laura, Aisoni, Filippo, Rossin, Eleonora, Pepe, Francesco, Marchetti, Francesco, Picardi, Biagio, Rossi, Stefano, Rossi Del Monte, Simone, Picarelli, Matteo, Muttillo, Irnerio A, Ratto, Carlo, Marra, Angelo A, Parello, Angelo, Litta, Francesco, Campennì, Paola, De Simone, Veronica, Pata, Francesco, Riboni, Cristiana, Rausa, Emanuele, Celentano, Valerio, Institut Català de la Salut, [Rottoli M, Gori A, Pellino G] Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero–Universitaria di Bologna, Bologna, Italy. Surgery of the Alimentary Tract, IRCCS Azienda Ospedaliero–Universitaria di Bologna, Bologna, Italy. [Pellino G] Department of Advanced Medical and Surgical Sciences, Università degli Studi della Campania Luigi Vanvitelli, Naples, Italy. Unitat de Cirurgia de Còlon i Recte, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Flacco ME, Martellucci C] Department of Environmental and Preventive Sciences, University of Ferrara, Ferrara, Italy. [Spinelli A] Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy. Colorectal Surgery, IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy, Vall d'Hebron Barcelona Hospital Campus, Rottoli, Matteo, Gori, Alice, Pellino, Gianluca, Flacco, Maria Elena, Martellucci, Cecilia, Spinelli, Antonino, Poggioli, Gilberto, Romano, Angela, Belvedere, Angela, Lanci Lanci, Antonio, Parlanti, Daniele, Vago, Gabriele, Pezzuto, Paola, Canavese, Anna, Dajti, Gerti, Cardelli, Stefano, Catalioto, Caterina, Russo, Iris S, Violante, Tommaso, Morezzi, Daniele, Maurino, Ludovica, Filippone, Eleonora, Cuicchi, Dajana, Bernante, Paolo, Jovine, Elio, Lombardi, Raffaele, Masetti, Michele, Cipressi, Chiara, Offi, Maria F, Larotonda, Cristina, Puglisi, Silvana B, Barbosa, Augusto, Vaiana, Roberto, Bianchi, Paolo M, Tonti, Carlo, Codignola, Claudio, Zorcolo, Luigi, Restivo, Angelo, Deidda, Simona, Marchetti, Marcello E, Ippolito, Luca, Spolverato, Gaya, Pucciarelli, Salvatore, Marchegiani, Francesco, Ghio, Giacomo, Zagolin, Gaya, Glavas, Dajana, Tomassi, Monica, Rosati, Riccardo, Elmore, Ugo, Gozzini, Lorenzo, Calef, Riccardo, Puccetti, Francesco, Cossu, Andrea, Vignali, Andrea, Morino, Mario, Allaix, Marco E, Cannata, Gaspare, Lombardi, Erica, Ammirati, Carlo A, Piceni, Chiara, Buccianti, Piero, Balestri, Riccardo, Puccini, Marco, Pezzati, Daniele, d'Ischia, Roberto, Asta, Vito F, Sargenti, Benedetta, Taddei, Giacomo, Bonari, Federica, Boni, Giulia, Ferrero, Alessandro, Mineccia, Michela, Gonella, Federica, Palisi, Marco, Danese, Francesco, Cherubini, Valeria, Perotti, Serena, Carvello, Michele, Carbone, Fabio, Luberto, Antonio, Calafiore, Eleonora, De Lucia, Francesca, Sacchi, Matteo, Sasia, Diego, Giuffrida, Maria C, Ballauri, Edoardo, Cardile, Mathieu, Armentano, Serena, Beltrami, Elsa, Preve, Gabriele, Vercellone, Barbara, Mozzon, Marta, Folliero, Cristina, Lirusso, Chiara, Vecchiato, Massimo, Ziccarelli, Antonio, Gattesco, Davide, Moretti, Luisa, Crestale, Sara, Banchini, Filippo, Capelli, Patrizio, Romboli, Andrea, Palmieri, Gerardo, Conti, Luigi, Rizzi, Nichola, Bonfili, Deborah, de Manzini, Nicolò, Germani, Paola, Osenda, Edoardo, Cortinovis, Sara, Giunta, Carlotta, Fracon, Stefano, Abdallah, Hussein, Bogoni, Selene, Portolani, Nazario, Nascimbeni, Riccardo, Molfino, Sarah, Tiberio, Guido A M, Garosio, Ilenia, Lamperti, Giulia, Rigosa, Diego, Ercolani, Giorgio, Solaini, Leonardo, Cavaliere, Davide, Avanzolini, Andrea, D'Acapito, Fabrizio, Chiarella, Leonardo L, Di Pietrantonio, Daniela, Annunziata, Domenico, Piccolo, Roberta, Sorrentino, Mario, Pansini, Mauro, Cojutti, Alessandro, Graziano, Michele, Callegari, Francesco, Balzarotti, Laura, Dameno, Vitale R, Cattaneo, Antonio, Santolamazza, Giuliano, Altieri, Caterina, Magarini, Riccardo, Pietrabissa, Andrea, Dominioni, Tommaso, Pugliese, Luigi, Peri, Andrea, Botti, Marta, Salvetti, Francesco, Cassinotti, Elisa, Baldari, Ludovica, Boni, Luigi, Messina, Valentina, D'Abrosca, Vera, Cianci, Pasquale, Tumolo, Rocco, Gattulli, Domenico, Restini, Enrico, Minafra, Marina, Sederino, Maria G, Bottalico, Bernardino, Pilati, Pierluigi, Franzato, Bori, Mattara, Genny, De Simoni, Ottavia, Barina, Andrea, Tonello, Marco, Muratore, Andrea, Calabrò, Marcello, Federico Pipitone, Nicoletta S, Cuzzola, Bruno, Herranz van Nood, Elena, Passuello, Nicola, Frasson, Alvise, Mammano, Enzo, Faccio, Luca, Vittadello, Fabrizio, Bressan, Alice, Sarzo, Giacomo, Tamini, Nicolò, Oldani, Massimo, Cigagna, Luca, Carissimi, Francesca, De Carlo, Giulia, Baccalini, Edoardo, Nespoli, Luca, Giordano, Alessio, Cantafio, Stefano, Grifoni, Lucrezia, Matani, Davide, Livi, Serena, Delogu, Daniele, Scognamillo, Fabrizio, Marrosu, Antonio, Guerrini, Luca, Ugolini, Giampaolo, Ghignone, Federico, Frascaroli, Giacomo, Albertini, Nicola, Zattoni, Davide, Taffurelli, Giovanni, Montroni, Isacco, Colombo, Francesco, Danelli, Piergiorgio, Bondurri, Andrea, Maffioli, Anna, Bonomi, Alessandro, Pezzoli, Isabella, Cammarata, Francesco, Goletti, Orlando, Molteni, Mattia, Assisi, Alberto, Quartierini, Giorgio, Da Lio, Corrado, Verdi, Daunia, Mondi, Isabella, Peluso, Claudia, Macchi, Lorenzo, Tanzanu, Marta, Zanzi, Federico, Pellegrini, Sara, Andreuccetti, Jacopo, D'Alessio, Rossella, Pignata, Giusto, De Capua, Michele, Canfora, Ilaria, Ottaviani, Luca, Lepiane, Pasquale, Balla, Andrea, De Carlo, Antonio, Saraceno, Federica, Scaramuzzo, Rosa, Guida, Anna, Aguzzi, Daniele, Bellora, Paolo, Gentilli, Sergio, Monni, Manuela, Nikaj, Herald, Cillara, Nicola, Cannavera, Alessandro, Deserra, Antonello, Margiani, Carla, Cabula, Roberta, Dettori, Manuela, Gramignano, Giulia, Lezoche, Giovanni, Ortenzi, Monica, Orlandoni, Elena S, Curzi, Federica, Vitali, Francesca, Capomagi, Perla, Palmieri, Miriam, Giuffrida, Mario, Del Rio, Paolo, Bonati, Elena, Loderer, Tommaso, Cozzani, Federico, Rossini, Matteo, Agnesi, Stefano, Capolupo, Gabriella T, Caricato, Marco, Carannante, Filippo, Mascianà, Gianluca, Marrelli, Martina, Miacci, Valentina, Lauricella, Sara, Tonini, Valeria, Cervellera, Maurizio, Pisconti, Salvatore, Lozito, Concetta, Shahu, Juliana, Mongelli, Claudia, Morelli, Giulia, Sartarelli, Lodovico, Sica, Giuseppe S, Siragusa, Leandro, Bagaglini, Giulia, Sensi, Bruno, Guida, Andrea M, Franceschilli, Marzia, Vinci, Danilo, Taddei, Antonio, Risaliti, Matteo, Bartolini, Ilenia, Ringressi, Maria N, Tirloni, Luca, Laface, Letizia, Abate, Emmanuele, Casati, Massimiliano, Gobbi, Pietro, Opocher, Enrico, Mariani, Nicolò M, Pisani Ceretti, Andrea, Giovenzana, Marco, Giuliani, Beatrice, Sironi, Martina, Grossi, Ugo, Zanus, Giacomo, Aniello Santoro, Giulio, Brizzolari, Marco, De Leo, Eugenio, Novello, Simone, Aquilino, Krizia, Milardi, Francesco, Olmi, Stefano, Uccelli, Matteo, Bonaldi, Marta, Cesana, Giovanni C, Bindi, Marco, Galleano, Raffaele, Langone, Antonio, Botto, Massimiliano, Franceschi, Angelo, Gambino, Elena, Ronconi, Maurizio, Casiraghi, Silvia, Casole, Giovanni, Ciulla, Salvatore L, Terrosu, Giovanni, Calandra, Sergio, Scarpa, Edoardo, Cherchi, Vittorio, Calini, Giacomo, Martinuzzo, Lisa, Clocchiatti, Lucrezia, Muschitiello, Davide, Romanzi, Andrea, Vignati, Barbara, Vannelli, Alberto, Scolaro, Roberta, Milanesi, Maria, Rossi, Fabrizio, Canonico, Giuseppe, Anastasi, Alessandro, Nelli, Tommaso, Barlettai, Marco, Fratarcangeli, Riccardo, Di Martino, Carmela, Damigella, Andrea, Adinolfi, Elvira, Birindelli, Arianna, Taglietti, Lucio, Dester, Sara E, Fleres, Francesco, Cucinotta, Eugenio, Viscosi, Francesca, Biondo Santino, Antonio, Badessi, Giorgio, Catarsini, Nivia, Mazzeo, Carmelo, Rega, Daniela, Delrio, Paolo, Cervone, Carmela, Aversano, Alessia, De Franciscis, Silvia, Di Marzo, Massimiliano, Marra, Bruno, Pace, Ugo, Amato, Antonio, Batistotti, Paola, Mina, Elisa, Serventi, Alberto, Lapolla, Pierfrancesco, Mingoli, Andrea, Sapienza, Paolo, Brachini, Gioia, Cirillo, Bruno, Fiori, Enrico, Crocetti, Daniele, Clementi, Ilaria, Martines, Gennaro, Picciariello, Arcangelo, Tomasicchio, Giovanni, Dibra, Riger, Trigiante, Giuseppe, Rinaldi, Marcella, Lantone, Giuliano, Porcu, Alberto, Perra, Teresa, Scanu, Antonio M, Feo, Claudio F, Fancellu, Alessandro, Cossu, Maria L, Ginesu, Giorgio C, Patriti, Alberto, Coletta, Diego, Petrelli, Filippo, Greco, Paola A, Spadoni, Claudia, Cassiani, Giovanna, Bianchini, Federica, Arganini, Marco, Bianchini, Matteo, Perotti, Bruno, Palmeri, Matteo, Scabini, Stefano, Deiana, Selene, Carganico, Giacomo, Pertile, Davide, Soriero, Domenico, Fioravanti, Emanuela, Sperotto, Beatrice, Nardo, Bruno, Paglione, Daniele, Crocco, Veronica, Doni, Marco, Osso, Mariasara, Perri, Roberto, Sampietro, Gianluca M, Corbellini, Carlo, Lorusso, Leonardo, Manzo, Carlo A, Cigognini, Maria, Baldi, Caterina, Palomba, Giuseppe, Aprea, Giovanni, Capuano, Marianna, Basile, Raffaele, Tutino, Roberta, Massani, Marco, Marinelli, Laura, Canitano, Nicola, Pilia, Tiziana, Podda, Mauro, Pisanu, Adolfo, Murzi, Valentina, Incani, Silvia, Frongia, Federica, Esposito, Giuseppe, Luglio, Gaetano, Tropeano, Francesca P, Pagano, Gianluca, Spina, Eduardo, De Simone, Giuseppe, Cricrì, Michele, Catena, Fausto, Vallicelli, Carlo, Zanini, Nicola, Ronconi, Diana, Favi, Francesco, Mazzucchelli, Carlo, Convertini, Girolamo, Vincenti, Leonardo, Andriola, Valeria, Bizzoca, Cinzia, Feo, Carlo V, Fabbri, Nicolò, Fazzin, Marta, Pesce, Antonio, Gennari, Silvia, Torchiaro, Marco, Severi, Silvia, Frontali, Alice, Bracchetti, Greta, Granieri, Stefano, Cotsoglou, Christian, Carlini, Massimo, Lisi, Giorgio, Spoletini, Domenico, Mastrangeli, Maria R, Campanelli, Michela, Manigrasso, Michele, Milone, Marco, De Palma, Giovanni D, Vertaldi, Sara, Chini, Alessia, Maione, Francesco, Marello, Alessandra, Selvaggi, Francesco, Sciaudone, Guido, Selvaggi, Lucio, Menegon Tasselli, Francesco, Fuschillo, Giacomo, Oddis, Lidia, Grande, Simona, Grande, Michele, Ascanelli, Simona, Chimisso, Laura, Aisoni, Filippo, Rossin, Eleonora, Pepe, Francesco, Marchetti, Francesco, Picardi, Biagio, Rossi, Stefano, Rossi Del Monte, Simone, Picarelli, Matteo, Muttillo, Irnerio A, Ratto, Carlo, Marra, Angelo A, Parello, Angelo, Litta, Francesco, Campennì, Paola, De Simone, Veronica, Pata, Francesco, Riboni, Cristiana, Rausa, Emanuele, and Celentano, Valerio

Subjects
Adult, Male, Settore MED/18 - CHIRURGIA GENERALE, Otros calificadores::/diagnóstico [Otros calificadores], Hospitals, Community, colorectal cancer, Community, advanced stage, COVID-19 (Malaltia), Cohort Studies, Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms [DISEASES], Retrospective Studie, Other subheadings::/diagnosis [Other subheadings], virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], Humans, Pandemics, Aged, Retrospective Studies, Pandemic, SARS-CoV-2, COVID-19, Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], General Medicine, neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales [ENFERMEDADES], Hospitals, Recte - Càncer - Diagnòstic, Settore MED/18, Italy, Còlon - Càncer - Diagnòstic, Cohort Studie, Colorectal Neoplasms, Human
Abstract

ImportanceDelays in screening programs and the reluctance of patients to seek medical attention because of the outbreak of SARS-CoV-2 could be associated with the risk of more advanced colorectal cancers at diagnosis.ObjectiveTo evaluate whether the SARS-CoV-2 pandemic was associated with more advanced oncologic stage and change in clinical presentation for patients with colorectal cancer.Design, Setting, and ParticipantsThis retrospective, multicenter cohort study included all 17 938 adult patients who underwent surgery for colorectal cancer from March 1, 2020, to December 31, 2021 (pandemic period), and from January 1, 2018, to February 29, 2020 (prepandemic period), in 81 participating centers in Italy, including tertiary centers and community hospitals. Follow-up was 30 days from surgery.ExposuresAny type of surgical procedure for colorectal cancer, including explorative surgery, palliative procedures, and atypical or segmental resections.Main Outcomes and MeasuresThe primary outcome was advanced stage of colorectal cancer at diagnosis. Secondary outcomes were distant metastasis, T4 stage, aggressive biology (defined as cancer with at least 1 of the following characteristics: signet ring cells, mucinous tumor, budding, lymphovascular invasion, perineural invasion, and lymphangitis), stenotic lesion, emergency surgery, and palliative surgery. The independent association between the pandemic period and the outcomes was assessed using multivariate random-effects logistic regression, with hospital as the cluster variable.ResultsA total of 17 938 patients (10 007 men [55.8%]; mean [SD] age, 70.6 [12.2] years) underwent surgery for colorectal cancer: 7796 (43.5%) during the pandemic period and 10 142 (56.5%) during the prepandemic period. Logistic regression indicated that the pandemic period was significantly associated with an increased rate of advanced-stage colorectal cancer (odds ratio [OR], 1.07; 95% CI, 1.01-1.13; P = .03), aggressive biology (OR, 1.32; 95% CI, 1.15-1.53; P P = .03).Conclusions and RelevanceThis cohort study suggests a significant association between the SARS-CoV-2 pandemic and the risk of a more advanced oncologic stage at diagnosis among patients undergoing surgery for colorectal cancer and might indicate a potential reduction of survival for these patients.

Published
2022

28. Contributors

Author

Aceto, Paola, Agresta, Ferdinando, Ansaloni, Luca, Arora, Amit, Arora, Anmol, Astro, Giancarlo, Audisio, Riccardo A., Barbara, Silvia Jasmine, Bergamini, Carlo, Bettelli, Gabriella, Bianco, Céline, Bicknell, Brenton T., Braga, Marco, Brattinga, Baukje, Bui, Tri-Vu, Buzzi, Matilde, Campanile, Fabio Cesare, Cangiano, Iacopo, Carli, Franco, Catena, Fausto, Cattaneo, Martina, Ceresoli, Marco, Churton, Alexander James, Costantini, Maurizio, Crome, Peter, Dunn, Emily, Flaatten, Hans, Fugazzola, Paola, Fujikawa, Hirohisa, Gallo, Lucas, Greco, Massimiliano, Griffiths, Ewen A., Guidet, Bertrand, Halle-Smith, James M., Herrera-Zamora, Julio, Hsieh, MinJia, Hughes, Clare, Jacqueline, Sim Xiu Ling, Jaklitsch, Michael T., Lozzi, Federica, Luca, Ersilia, McAllister, Miles, McCammon, Susan D., Mencucci, Rita, Meretoja, Tuomo, Montori, Giulia, Montroni, Isacco, Morganti, Wanda, Moross, Janelle, Mossello, Enrico, Naumann, David N., Ogawa, Takahisa, Pezeshkian, Fatemehsadat, Pilotto, Alberto, Piva, Ilaria R., Procida, Giuseppa, Ramello, Monica, Roberson, Jeffrey L., Rocco, Ilaria, Romagnoni, Franco, Rostoft, Siri, Rouleau, Caroline, Royer, Luca, Russell, Marcia M., Salzman, Garrett A., Sandrucci, Sergio, Santandrea, Giorgia, Saur, Nicole M., Schermann, Haggai, Shah, Tanuja, Singh, Anupama, Su, Yang-Chin, Taffurelli, Giovanni, Tamminen, Anselm, Teggi, Roberto, Thoma, Achilles, Thomas, Carissa M., Ugolini, Giampaolo, Vallet, Hélène, Vallicelli, Carlo, van der Wal-Huisman, Hanneke, van Leeuwen, Barbara L., and Wodeyar, Akhilesh

Published
2025
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33. Predicting Functional Recovery and Quality of Life in Older Patients Undergoing Colorectal Cancer Surgery: Real-World Data From the International GOSAFE Study.

Author

Montroni, Isacco, Ugolini, Giampaolo, Saur, Nicole M., Rostoft, Siri, Spinelli, Antonino, Van Leeuwen, Barbara L., De Liguori Carino, Nicola, Ghignone, Federico, Jaklitsch, Michael T., Kenig, Jakub, Garutti, Anna, Zingaretti, Chiara, Foca, Flavia, Vertogen, Bernadette, Nanni, Oriana, Wexner, Steven D., Audisio, Riccardo A., Taffurelli, Giovanni, Zattoni, Davide, and Tramelli, Paola

Published
2023
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35. 5 year oncological outcomes of the HIGHLOW randomized clinical trial

Author

Mari, Giulio, primary, Santambrogio, Gaia, additional, Crippa, Jacopo, additional, Cirocchi, Roberto, additional, Origi, Matteo, additional, Achilli, Pietro, additional, Ferrari, Giovanni, additional, Megna, Stefano, additional, Desio, Matteo, additional, Cocozza, Eugenio, additional, Maggioni, Dario, additional, Montroni, Isacco, additional, Spinelli, Antonino, additional, Zuliani, Walter, additional, Costanzi, Andrea, additional, Crestale, Sara, additional, Petri, Roberto, additional, Bicelli, Noemi, additional, Pedrazzani, Corrado, additional, Boccolini, Andrea, additional, Taffurelli, Giovanni, additional, and Fingerhut, Abe, additional

Published
2022
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40. Immediate versus early (24-hours) urinary catheter removal after elective minimally invasive colonic resection: study protocol for a randomized, multicenter, non-inferiority trial

Author

Pedrazzani, Corrado, primary, Montroni, Isacco, additional, Conti, Cristian, additional, Turri, Giulia, additional, Foppa, Caterina, additional, Carvello, Michele, additional, Taffurelli, Giovanni, additional, Ugolini, Giampaolo, additional, and Spinelli, Antonino, additional

Published
2022
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41. Additional file 1 of Immediate versus early (24-hours) urinary catheter removal after elective minimally invasive colonic resection: study protocol for a randomized, multicenter, non-inferiority trial

Author

Pedrazzani, Corrado, Montroni, Isacco, Conti, Cristian, Turri, Giulia, Foppa, Caterina, Carvello, Michele, Taffurelli, Giovanni, Ugolini, Giampaolo, and Spinelli, Antonino

Abstract

Additional file 1. Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) checklist.

Published
2022
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46. Impatto della tecnica 'Radical Proximal-Distal Modular Pancreatosplenectomy (RAMPS)' nella pancreasectomia distale per tumori maligni del pancreas

Author

Taffurelli, Giovanni <1985> and Minni, Francesco

Subjects
MED/18 Chirurgia generale
Abstract

Background: Nel 2003 è stata descritta una variante alla classica spleno-pancreasectomia distale (SP-classica), definita radical antegrade modular pancreatosplenectomy (RAMPS), per ottenere una resezione più estesa nel trattamento dei tumori del corpo-coda pancreatico. Gli endpoints di questa tesi sono stati valutare gli outcomes postoperatori ed oncologici della RAMPS. Materiali e metodi: Da un database prospettico sono stati estratti i dati di 209 pazienti sottoposti a SP-classica o RAMPS nella Chirurgia Pancreas-Endocrino Prof. Minni dal 2004 al 2020. Gli interventi per neoplasia maligna (n=123) sono stati suddivisi in base alla tecnica. Gli outcomes oncologici dei pazienti affetti da adenocarcinoma duttale (N=62) sono stati valutati mediante uni e multivariata sulla sopravvivenza globale (OS) e libera da malattia (DFS), Risultati: I due gruppi sono risultati omogenei per caratteristiche preoperatorie ed intraoperatorie. La RAMPS ha mostrato un Comprehensive Complication Index (P=0.039) maggiore, mentre i gruppi erano sovrapponibili per fistole pancreatiche, emorragie, reinterventi, mortalità e degenza. Staging, grading ed invasione perineurale dei tumori sono risultati similari. I tassi di R0 sui margini sono stati sovrapponibili, tranne un minor tasso di R0 sul margine anteriore nelle RAMPS (P=0.004). La RAMPS è stata superiore in termini di linfadenectomia (P=0.007), mentre non vi sono state differenze né di OS (P=0.170) né di DFS (P=0.857). Le analisi multivariate hanno confermato che la tecnica chirurgica non era associata alla sopravvivenza. Dimensioni tumorali (HR 1.05; P=0.001), invasione linfo-vascolare (HR 4.03; P=0.002) e margine posteriore R1 (HR 2.4; P=0.035) sono risultati correlati a diminuite OS e DFS. Conclusioni: Nella nostra esperienza la RAMPS può essere considerata utile e sicura per il trattamento dei tumori maligni del corpo-coda pancreatico. La sola tecnica non si associa a variazioni di DFS o di OS, rimanendo la biologia del tumore il fattore cardine. La RAMPS consente di ottenere una linfadenectomia più radicale, migliorando la stadiazione della malattia., Background: In 2003 radical antegrade modular pancreatosplenectomy (RAMPS) was described as a technical variant of classic distal spleno-pancreasectomy (classic-SP) to gain a wider and deeper resection. The endpoint of this study is to evaluate surgical and oncological outcomes of RAMPS. Methods: From a prospective database, data about 209 patients surgically treated between 2004 to 2020 with classic-SP or RAMPS at the Pancreatic Surgical Unit-Prof. Minni were analyzed. Patients with malignant neoplasms (n=123) were divided basing on surgical technique. Oncological outcomes, overall survival (OS) and disease free survival (DFS) of patients with pancreatic ductal adenocarcinoma (N=62) were compared at uni and multivariate analysis. Results: Both groups were similar for preoperative and intraoperative characteristics. RAMPS showed a higher Comprehensive Complication Index (P=0.039), while the two groups were similar for pancreatic fistulas, haemorrages, reintervention, mortality and length of stay. Staging, grading and perineural invasion were comparable. R0 rates were equivalent, except for a lower anterior margin R0 rate in the RAMPS group (P=0.004). RAMPS was superior in terms of lymphadenectomy (P=0.007). No differences were found neither for OS (P=0.170) nor for DFS (P=0.857). Multivariate analyses confirmed that the two techniques were not related to survival. Tumor size (HR 1.05; P=0.001), lymph-vascular invasion (HR 4.03; P=0.002) and an R1 posterior resection margin (HR 2.4; P=0.035) were all related to reduced OS e DFS. Conclusions: In our experience, RAMPS could be considered useful and safe in treating body-tail pancreatic cancer. Surgical technique alone did not correlate with DFS nor OS, but tumor biology is still the cornerstone in predicting survival. RAMPS is related to a better lymphadenectomy, improving a better staging of the disease.

Published
2021
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47. Impatto della tecnica 'Radical Proximal-Distal Modular Pancreatosplenectomy (RAMPS)' nella pancreasectomia distale per tumori maligni del pancreas

Author

Minni, Francesco, Taffurelli, Giovanni <1985>, Minni, Francesco, and Taffurelli, Giovanni <1985>

Abstract

Background: Nel 2003 è stata descritta una variante alla classica spleno-pancreasectomia distale (SP-classica), definita radical antegrade modular pancreatosplenectomy (RAMPS), per ottenere una resezione più estesa nel trattamento dei tumori del corpo-coda pancreatico. Gli endpoints di questa tesi sono stati valutare gli outcomes postoperatori ed oncologici della RAMPS. Materiali e metodi: Da un database prospettico sono stati estratti i dati di 209 pazienti sottoposti a SP-classica o RAMPS nella Chirurgia Pancreas-Endocrino Prof. Minni dal 2004 al 2020. Gli interventi per neoplasia maligna (n=123) sono stati suddivisi in base alla tecnica. Gli outcomes oncologici dei pazienti affetti da adenocarcinoma duttale (N=62) sono stati valutati mediante uni e multivariata sulla sopravvivenza globale (OS) e libera da malattia (DFS), Risultati: I due gruppi sono risultati omogenei per caratteristiche preoperatorie ed intraoperatorie. La RAMPS ha mostrato un Comprehensive Complication Index (P=0.039) maggiore, mentre i gruppi erano sovrapponibili per fistole pancreatiche, emorragie, reinterventi, mortalità e degenza. Staging, grading ed invasione perineurale dei tumori sono risultati similari. I tassi di R0 sui margini sono stati sovrapponibili, tranne un minor tasso di R0 sul margine anteriore nelle RAMPS (P=0.004). La RAMPS è stata superiore in termini di linfadenectomia (P=0.007), mentre non vi sono state differenze né di OS (P=0.170) né di DFS (P=0.857). Le analisi multivariate hanno confermato che la tecnica chirurgica non era associata alla sopravvivenza. Dimensioni tumorali (HR 1.05; P=0.001), invasione linfo-vascolare (HR 4.03; P=0.002) e margine posteriore R1 (HR 2.4; P=0.035) sono risultati correlati a diminuite OS e DFS. Conclusioni: Nella nostra esperienza la RAMPS può essere considerata utile e sicura per il trattamento dei tumori maligni del corpo-coda pancreatico. La sola tecnica non si associa a variazioni di DFS o di OS, rimanendo la biologia del tumore il fat, Background: In 2003 radical antegrade modular pancreatosplenectomy (RAMPS) was described as a technical variant of classic distal spleno-pancreasectomy (classic-SP) to gain a wider and deeper resection. The endpoint of this study is to evaluate surgical and oncological outcomes of RAMPS. Methods: From a prospective database, data about 209 patients surgically treated between 2004 to 2020 with classic-SP or RAMPS at the Pancreatic Surgical Unit-Prof. Minni were analyzed. Patients with malignant neoplasms (n=123) were divided basing on surgical technique. Oncological outcomes, overall survival (OS) and disease free survival (DFS) of patients with pancreatic ductal adenocarcinoma (N=62) were compared at uni and multivariate analysis. Results: Both groups were similar for preoperative and intraoperative characteristics. RAMPS showed a higher Comprehensive Complication Index (P=0.039), while the two groups were similar for pancreatic fistulas, haemorrages, reintervention, mortality and length of stay. Staging, grading and perineural invasion were comparable. R0 rates were equivalent, except for a lower anterior margin R0 rate in the RAMPS group (P=0.004). RAMPS was superior in terms of lymphadenectomy (P=0.007). No differences were found neither for OS (P=0.170) nor for DFS (P=0.857). Multivariate analyses confirmed that the two techniques were not related to survival. Tumor size (HR 1.05; P=0.001), lymph-vascular invasion (HR 4.03; P=0.002) and an R1 posterior resection margin (HR 2.4; P=0.035) were all related to reduced OS e DFS. Conclusions: In our experience, RAMPS could be considered useful and safe in treating body-tail pancreatic cancer. Surgical technique alone did not correlate with DFS nor OS, but tumor biology is still the cornerstone in predicting survival. RAMPS is related to a better lymphadenectomy, improving a better staging of the disease.

Published
2021

49. High Versus Low Ligation of the Inferior Mesenteric Artery During Rectal Resection for Cancer: Oncological Outcomes After Three Years of Follow-Up From the HIGHLOW Trial

Author

Mari, Giulio M., primary, Crippa, Jacopo, additional, Achilli, Pietro, additional, Montroni, Isacco, additional, Ugolini, Giampaolo, additional, Taffurelli, Giovanni, additional, Cocozza, Eugenio, additional, Borroni, Giacomo, additional, Valenti, Francesco, additional, Roscio, Francesco, additional, Ferrari, Giovanni, additional, Origi, Matteo, additional, Zuliani, Walter, additional, Pugliese, Raffaele, additional, Costanzi, Andrea T. M., additional, Fingherut, Abe, additional, and Maggioni, Dario, additional

Published
2020
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50. GOSAFE - Geriatric Oncology Surgical Assessment and Functional rEcovery after Surgery: early analysis on 977 patients

Author

Montroni, Isacco, primary, Rostoft, Siri, additional, Spinelli, Antonino, additional, Van Leeuwen, Barbara L., additional, Ercolani, Giorgio, additional, Saur, Nicole M., additional, Jaklitsch, Michael T., additional, Somasundar, Ponnandai S., additional, de Liguori Carino, Nicola, additional, Ghignone, Federico, additional, Foca, Flavia, additional, Zingaretti, Chiara, additional, Audisio, Riccardo A., additional, Ugolini, Giampaolo, additional, Garutti, Anna, additional, Taffurelli, Giovanni, additional, Zattoni, Davide, additional, Tramelli, Paola, additional, Sermonesi, Giacomo, additional, Di Candido, Francesca, additional, Carvello, Michele, additional, Sacchi, Matteo, additional, De Lucia, Francesca, additional, Foppa, Caterina, additional, Plas, Matthijs, additional, Van der Wal-Huisman, Hanneke, additional, Tauceri, Francesca, additional, Perenze, Barbara, additional, Di Pietrantonio, Daniela, additional, Mirarchi, Mariateresa, additional, Fejka, Michael, additional, Bleier, Joshua I.S., additional, Frain, Laura, additional, Fox, Sam W., additional, Cardin, Kristin, additional, De Leon, Luis E., additional, Baltatzis, Minas, additional, Chan, Anthony K.C., additional, Siriwardena, Ajith K., additional, Vertogen, Bernadette, additional, Nanni, Oriana, additional, Garulli, Gianluca, additional, Alagna, Vincenzo, additional, Pirrera, Basilio, additional, Lucchi, Andrea, additional, Monari, Francesco, additional, Conti, Luigi, additional, Capelli, Patrizio, additional, Romboli, Andrea, additional, Palmieri, Gerardo, additional, Banchini, Filippo, additional, Marano, Luigi, additional, Spaziani, Alessandro, additional, Castagnoli, Giampaolo, additional, Bartoli, Alberto, additional, Trompetto, Mario, additional, Gallo, Gaetano, additional, Luc, Alberto Realis, additional, Clerico, Giuseppe, additional, Sammarco, Giuseppe, additional, De Luca, Raffaele, additional, Barile, Graziana, additional, Simone, Michele, additional, Costanzi, Andrea, additional, Mari, Giulio, additional, Maggioni, Dario, additional, Pellegrino, Roberta, additional, Riggio, Valentina, additional, Kenig, Jakub, additional, Szabat, Kinga, additional, Scabini, Stefano, additional, Pertile, Davide, additional, Stratta, Emanuela, additional, Massobrio, Andrea, additional, Soriero, Domenico, additional, Nesbakken, Arild, additional, Lønn, Mariann, additional, Backe, Ingeborg Flåten, additional, Ferrari, Giovanni, additional, Mazzola, Michele, additional, Alampi, Bruno D.A., additional, Achilli, Pietro, additional, Sfondrini, Stefano, additional, Ioannidis, Orestis, additional, Loutzidou, Lydia, additional, Galanos-Demiris, Konstantinos, additional, Pellino, Gianluca, additional, Balducci, Genoveffa, additional, Frezza, Barbara, additional, Lucarini, Alessio, additional, Santos, Claudia, additional, Cooper, Lisa, additional, Siam, Baha, additional, Levy, Yochai, additional, Brenner, Baruch, additional, Kashtan, Hanoch, additional, Belgrano, Valerio, additional, De Cian, Franco, additional, Palermo, Beatrice, additional, Eggenhöffner, Roberto, additional, Albertelli, Manuela, additional, Sánchez-Guillén, Luis, additional, Arroyo, Antonio, additional, López-Rodríguez, Francisco, additional, Lario, Sandra, additional, Lillo, Cristina, additional, and Wexner, Steven D., additional

Published
2020
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