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493 results on '"TAKASAKA, T."'

23. A general structure for a time-domain model of the cochlea

Author

Duifhuis, H, Wada, H, Takasaka, T, Ikeda, K, and Koike, T

Abstract

This study presents an implementation of our basic ideas about a time-domain nonlinear model of the cochlea. The time-domain approach is considered necessary because it allows implementation of nonlinearity in general and of a proper temporal analysis of natural transient responses in particular. It should be considered a useful step towards a realistic biophysical model of the cochlea, which so far has been claimed by several colleagues, but in my opinion is still far from being accomplished. Several very different approaches are worked out separately, but convergence to a general solution remains to be achieved, as is also clear from a number of presentations at this conference. In this paper I will briefly mention some of the problems of current state of the art approaches. Unfortunately I will not be able to give all the solutions. I will focus on the general structure of a useful as well as promising model.

Published
2000

26. Inhibitory effect of erythromycin on interleukin-8 secretion from exudative cells in the nasal discharge of patients with chronic sinusitis.

Author

Suzuki H, Asada Y, Ikeda K, Oshima T, Takasaka T, Suzuki, H, Asada, Y, Ikeda, K, Oshima, T, and Takasaka, T

Abstract

Objectives: The mechanism of the efficacy of long-term low-dose macrolide therapy for chronic sinusitis is not fully understood. The authors studied the inhibitory effect of erythromycin on interleukin-8 (IL-8) secretion from exudative cells in the nasal discharge of patients with chronic sinusitis.Study Design and Methods: Exudative cells in the nasal discharge were isolated from six patients with nonallergic chronic sinusitis. The cells, more than 90% of which were neutrophils, were incubated with or without erythromycin in the presence of 10 micrograms/mL of lipopolysaccharide. The IL-8 concentrations in the culture supernatants were measured by enzyme-linked immunoassay.Results: The amount of secreted IL-8 in the absence of erythromycin was 682 +/- 226 pg/10(6) cells/24 h. The IL-8 secretion was significantly reduced to 66 +/- 15% and 46 +/- 13% of the control in the presence of 10(-6) and 10(-5) M of erythromycin, respectively.Conclusion: Erythromycin may act as a biologic modulator that inhibits IL-8 secretion from exudative cells and thereby blocks the vicious circle of neutrophil recruitment and IL-8 generation in the inflammatory site in chronic sinusitis. [ABSTRACT FROM AUTHOR]

Published
1999

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