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22 results on '"TANG, XIANGHUI"'

10. Long-term comparisons of the efficacy, safety, and pregnancy outcomes of adjuvant tamoxifen plus ovarian function suppression in premenopausal Han and Zhuang Chinese patients with hormone receptor-positive early breast cancer

Author

Tang, Shicong, Zhang, Qiong, Tang, Xianghui, Chen, Dong, Zhang, Fan, Liu, Jianlun, Wei, Wei, and Liu, Dequan

Abstract

Objective To compare the efficacy, safety, and pregnancy outcomes of tamoxifen plus ovarian function suppression (OFS) between Han and Zhuang women with hormone receptor-positive breast cancer.Methods A total of 236 Han and 101 Zhuang women with hormone receptor-positive breast cancer who received tamoxifen plus OFS were analyzed retrospectively. Long-term disease-free survival (DFS) and overall survival (OS) were evaluated by Kaplan–Meier analysis, and adverse events and pregnancy outcomes were assessed by χ2and Fisher’s exact-probability tests.Results There was no significant difference in DFS or OS between Han and Zhuang women (5-year DFS 74.57% and 77.23%, OS 85.59% and 90.01%, respectively). The incidences of endometrial hyperplasia, ovarian cysts, nausea and vomiting, fatty liver, retinitis, and thrombocytopenic purpura were similar in both groups, but Zhuang women had significantly more allergic reactions (6.93% vs. 2.12%). Pregnancy rates among women who attempted pregnancy were similar (Han, 7/138, 5.07%; Zhuang, 2/46, 4.35%).Conclusions OFS plus tamoxifen resulted in similar DFS and OS among premenopausal Han and Zhuang women with hormone receptor-positive breast cancer. However, Zhuang women were more likely to experience an allergic reaction. For women with fertility concerns, OFS plus tamoxifen was associated with similar pregnancy rates in Zhuang and Han women.

Published
2019
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11. Epigenetic marks in cloned rhesus monkey embryos: Comparison with counterparts produced in vitro

Author

Yang, Jifeng, Yang, Shihua, Beaujean, Nathalie, Niu, Yuyu, He, Xiechao, Xie, Yunhua, Tang, Xianghui, Wang, Liu, Zhou, Qi, Ji, Weizhi, Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences, CAS (UCAS), Biologie du développement et reproduction (BDR), and Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)

Subjects
EMBRYONIC DEVELOPMENT, EPIGENETIC REPROGRAMMING, HISTONE ACETYLATION, EARLY DEVELOPMENT, EMBRYO, IN VITRO FERTILIZATION, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, SOMATIC CELL NUCLEAR TRANSFER, DNA METHYLATION, RHESUS MONKEY, ComputingMilieux_MISCELLANEOUS, DONOR CELLS
Abstract

International audience

Published
2007

22. Generation and characterization of rabbit embryonic stem cells.

Author

Wang S, Tang X, Niu Y, Chen H, Li B, Li T, Zhang X, Hu Z, Zhou Q, and Ji W

Subjects
Animals, Biomarkers metabolism, Cell Differentiation, Cells, Cultured, Embryonic Stem Cells metabolism, Female, Genes, Germ Layers cytology, Humans, Karyotyping, Mice, Oocytes cytology, Rabbits, Transcription, Genetic, Embryonic Stem Cells cytology
Abstract

We described the derivation of four stable pluripotent rabbit embryonic stem cell (ESC) lines, one (RF) from blastocysts fertilized in vivo and cultured in vitro and three (RP01, RP02, and RP03) from parthenogenetic blastocysts. These ESC lines have been cultivated for extended periods (RF >1 year, RP01 >8 months, RP02 >8 months, and RP03 >6 months) in vitro while maintaining expression of pluripotent ESC markers and a normal XY or XX karyotype. The ESCs from all lines expressed alkaline phosphatase, transcription factor Oct-4, stage-specific embryonic antigens (SSEA-1, SSEA-3, and SSEA-4), and the tumor-related antigens (TRA-1-60 and TRA-1-81). Similar to human and mouse ESCs, rabbit ESCs expressed pluripotency (Oct-4, Nanog, SOX2, and UTF-1) and signaling pathway genes (fibroblast growth factor, WNT, and transforming growth factor pathway). Morphologically, rabbit ESCs resembled primate ESCs, whereas their proliferation characteristics were more like those seen in mouse ESCs. Rabbit ESCs were induced to differentiate into many cell types in vitro and formed teratomas with derivatives of the three major germ layers in vivo when injected into severe combined immunodeficient mice. Our results showed that pluripotent, stable ESC lines could be derived from fertilized and parthenote-derived rabbit embryos.

Published
2007
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