3,002 results on '"TUMINO R."'
Search Results
2. Differences in the management and survival of metastatic colorectal cancer in Europe. A population-based study
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Van Eycken, L., Henau, K., Grozeva, T., Valerianova, Z., Innos, K., Mägi, M., Bouvier, V., Launoy, G., Robaszkiewicz, M., Bouvier, A.M., Jooste, V., Babaev, V., Katalinic, A., Ólafsdóttir, E.J., Tryggvadóttir, L., Amati, C., Baili, P., Bonfarnuzzo, S., Margutti, C., Meneghini, E., Minicozzi, P., Moretti, G., Sant, M., Cirilli, C., Carrozzi, G., Spata, E., Tumino, R., Rossi, P. Giorgi, Vicentini, M., Stracci, F., Bianconi, F., Contiero, P., Tagliabue, G., Kycler, W., Oko, M., Macek, P., Smok-Kalwat, J., Bielska-Lasota, M., Bento, M.J., Rodrigues, J, Mayer-da-Silva, A., Miranda, A., Primic-Žakelj, M., Jarm, K., Almar, E., Mateos, A., Bidaurrazaga, J., de la Cruz, M., Alberich, C., Torrella-Ramos, A., García, J.M. Díaz, Marcos-Navarro, AI, Carmona-Garcia, C., Marcos-Gragera, R., Luque-Fernandez, M.A., Sánchez-Pérez, M.J., Ardanaz, E., Guevara, M., Bouchardy, C., Fournier, E., Bouvier, Anne-Marie, Jooste, Valérie, Sanchez-Perez, Maria José, Bento, Maria José, Rocha Rodrigues, Jessica, Marcos-Gragera, Rafael, Carmona-Garcia, Maria Carmen, Luque-Fernandez, Miguel Angel, Minicozzi, Pamela, Bouvier, Véronique, Innos, Kaire, and Sant, Milena
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- 2021
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3. Comorbidities, timing of treatments, and chemotherapy use influence outcomes in stage III colon cancer: A population-based European study
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Van Eycken, L., Henau, K., Grozeva, T., Valerianova, Z., Innos, K., Mägi, M., Bouvier, V., Launoy, G., Jooste, V., Normand, S., Robaszkiewicz, M., Bouvier, A.-M., Faivre, J., Babaev, V., Katalinic, A., Ólafsdóttir, E.J., Tryggvadóttir, L., Amati, C., Baili, P., Bonfarnuzzo, S., Meneghini, E., Minicozzi, P., Moretti, G., Sant, M., Cirilli, C., Carrozzi, G., Spata, E., Tumino, R., Giorgi Rossi, P., Vicentini, M., Stracci, F., Bianconi, F., Contiero, P., Tagliabue, G., Kycler, W., Oko, M., Macek, P., Smok-Kalwat, J., Bielska-Lasota, M., Bento, M.J., Castro, C., Mayer-da-Silva, A., Miranda, A., Primic Žakelj, M., Jarm, K., Almar, E., Mateos, A., Bidaurrazaga, J., de la Cruz, M., Alberich, C., Torrella-Ramos, A., Marcos Navarro, A.I., Jiménez Chillarón, R., Carmona-Garcia, M.C., Marcos-Gragera, R., Rodriguez-Barranco, M., Sánchez, M.J., Ardanaz, E., Guevara, M., Bouchardy, C., Fournier, E., Minicozzi, Pamela, Vicentini, Massimo, Innos, Kaire, Castro, Clara, Guevara, Marcela, Stracci, Fabrizio, Carmona-Garcia, M<ce:sup loc='post">a</ce:sup>Carmen, Rodriguez-Barranco, Miguel, Vanschoenbeek, Katrijn, Rapiti, Elisabetta, Katalinic, Alexander, Marcos-Gragera, Rafael, Van Eycken, Liesbet, Sánchez, Maria José, Bielska-Lasota, Magdalena, Rossi, Paolo Giorgi, and Sant, Milena
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- 2020
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4. Dietary intake of advanced glycation end products (AGEs) and changes in body weight in European adults
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Cordova, R., Knaze, V., Viallon, V., Rust, P., Schalkwijk, C. G., Weiderpass, E., Wagner, K-H., Mayen-Chacon, A-L., Aglago, E. K., Dahm, C. C., Overvad, K., Tjønneland, A., Halkjær, J., Mancini, F. R., Boutron-Ruault, M-C., Fagherazzi, G., Katzke, V., Kühn, T., Schulze, M. B., Boeing, H., Trichopoulou, A., Karakatsani, A., Thriskos, P., Masala, G., Krogh, V., Panico, S., Tumino, R., Ricceri, F., Spijkerman, A., Boer, J., Skeie, G., Rylander, C., Borch, K. B., Quirós, J. R., Agudo, A., Redondo-Sánchez, D., Amiano, P., Gómez-Gómez, J-H., Barricarte, A., Ramne, S., Sonestedt, E., Johansson, I., Esberg, A., Tong, T., Aune, D., Tsilidis, K. K., Gunter, M. J., Jenab, M., and Freisling, Heinz
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- 2020
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5. The role of plasma microseminoprotein-beta in prostate cancer: an observational nested case–control and Mendelian randomization study in the European prospective investigation into cancer and nutrition
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Smith Byrne, K., Appleby, P.N., Key, T.J., Holmes, M.V., Fensom, G.K., Agudo, A., Ardanaz, E., Boeing, H., Bueno-de-Mesquita, H.B., Chirlaque, M.D., Kaaks, R., Larrañaga, N., Palli, D., Perez-Cornago, A., Quirós, J.R., Ricceri, F., Sánchez, M.J., Tagliabue, G., Tsilidis, K.K., Tumino, R., Fortner, R.T., Ferrari, P., Riboli, E., Lilja, H., and Travis, R.C.
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- 2019
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6. Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
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Obón-Santacana, M, Kaaks, R, Slimani, N, Lujan-Barroso, L, Freisling, H, Ferrari, P, Dossus, L, Chabbert-Buffet, N, Baglietto, L, Fortner, RT, Boeing, H, Tjønneland, A, Olsen, A, Overvad, K, Menéndez, V, Molina-Montes, E, Larrañaga, N, Chirlaque, M-D, Ardanaz, E, Khaw, K-T, Wareham, N, Travis, RC, Lu, Y, Merritt, MA, Trichopoulou, A, Benetou, V, Trichopoulos, D, Saieva, C, Sieri, S, Tumino, R, Sacerdote, C, Galasso, R, Bueno-de-Mesquita, HB, Wirfält, E, Ericson, U, Idahl, A, Ohlson, N, Skeie, G, Gram, IT, Weiderpass, E, Onland-Moret, NC, Riboli, E, and Duell, EJ
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Nutrition ,Clinical Research ,Prevention ,Cancer ,Aetiology ,2.2 Factors relating to the physical environment ,Cardiovascular ,Acrylamide ,Cohort Studies ,Diet ,Eating ,Endometrial Neoplasms ,Female ,Humans ,Middle Aged ,Nutritional Status ,Prospective Studies ,Risk ,Risk Factors ,Smoking ,acrylamide ,endometrial cancer ,type-I endometrial cancer ,cohort ,nutrition ,Oncology and Carcinogenesis ,Public Health and Health Services ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
BackgroundThree prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk.MethodsCox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method.ResultsNo associations were observed between acrylamide intake and overall EC (n=1382) or type-I EC risk (n=627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62; likelihood ratio test (LRT) P-value: 0.01, n=203).ConclusionsDietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.
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- 2014
7. Prediagnostic transcriptomic markers of Chronic lymphocytic leukemia reveal perturbations 10 years before diagnosis
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Chadeau-Hyam, M, Vermeulen, RCH, Hebels, DGAJ, Castagné, R, Campanella, G, Portengen, L, Kelly, RS, Bergdahl, IA, Melin, B, Hallmans, G, Palli, D, Krogh, V, Tumino, R, Sacerdote, C, Panico, S, de Kok, TMCM, Smith, MT, Kleinjans, JCS, Vineis, P, Kyrtopoulos, SA, consortium, on behalf of the EnviroGenoMarkers project, Georgiadis, P, Botsivali, M, Papadopoulou, C, Chatziioannou, A, Valavanis, I, Gottschalk, R, van Leeuwen, D, Timmermans, L, Keun, HC, Athersuch, TJ, Lenner, P, Bendinelli, B, Stephanou, EG, Myridakis, A, Kogevinas, M, Saberi-Hosnijeh, F, Fazzo, L, de Santis, M, Comba, P, Kiviranta, H, Rantakokko, P, Airaksinen, R, Ruokojarvi, P, Gilthorpe, MS, Fleming, S, Fleming, T, Tu, Y-K, Jonsson, B, Lundh, T, Chien, K-L, Chen, WJ, Lee, W-C, Hsiao, CK, Kuo, P-H, Hung, H, and Liao, S-F
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Genetic Testing ,Lymphoma ,Orphan Drug ,Genetics ,Hematology ,Cancer ,Rare Diseases ,Clinical Research ,2.1 Biological and endogenous factors ,Aetiology ,Adult ,Aged ,Biomarkers ,Tumor ,Case-Control Studies ,Female ,Genome ,Human ,Humans ,Leukemia ,Lymphocytic ,Chronic ,B-Cell ,Male ,Middle Aged ,Models ,Genetic ,Principal Component Analysis ,Prospective Studies ,Transcriptome ,epidemiology ,lymphoma ,chronic lymphocytic leukemia ,mRNA analyses ,prospective cohort ,EnviroGenoMarkers project consortium ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
BackgroundB-cell lymphomas are a diverse group of hematological neoplasms with differential etiology and clinical trajectories. Increased insights in the etiology and the discovery of prediagnostic markers have the potential to improve the clinical course of these neoplasms.MethodsWe investigated in a prospective study global gene expression in peripheral blood mononuclear cells of 263 incident B-cell lymphoma cases, diagnosed between 1 and 17 years after blood sample collection, and 439 controls, nested within two European cohorts.ResultsOur analyses identified only transcriptomic markers for specific lymphoma subtypes; few markers of multiple myeloma (N = 3), and 745 differentially expressed genes in relation to future risk of chronic lymphocytic leukemia (CLL). The strongest of these associations were consistently found in both cohorts and were related to (B-) cell signaling networks and immune system regulation pathways. CLL markers exhibited very high predictive abilities of disease onset even in cases diagnosed more than 10 years after blood collection.ConclusionsThis is the first investigation on blood cell global gene expression and future risk of B-cell lymphomas. We mainly identified genes in relation to future risk of CLL that are involved in biological pathways, which appear to be mechanistically involved in CLL pathogenesis. Many but not all of the top hits we identified have been reported previously in studies based on tumor tissues, therefore suggesting that a mixture of preclinical and early disease markers can be detected several years before CLL clinical diagnosis.
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- 2014
8. Childhood infectious diseases and risk of multiple myeloma : an analysis of the Italian multicentre case-control study
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Stagnaro, E., Parodi, S., Costantini, A. Seniori, Crosignani, P., Miligi, L., Nanni, O., Piro, S., Ramazzotti, V., Rodella, S., Tumino, R., Vindigni, C., and Vineis, P.
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- 2018
9. Trends in incidence of thick, thin and in situ melanoma in Europe
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Sacchetto, L., Zanetti, R., Comber, H., Bouchardy, C., Brewster, D.H., Broganelli, P., Chirlaque, M.D., Coza, D., Galceran, J., Gavin, A., Hackl, M., Katalinic, A., Larønningen, S., Louwman, M.W.J., Morgan, E., Robsahm, T.E., Sanchez, M.J., Tryggvadóttir, L., Tumino, R., Van Eycken, E., Vernon, S., Zadnik, V., and Rosso, S.
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- 2018
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10. Quality analysis of population-based information on cancer stage at diagnosis across Europe, with presentation of stage-specific cancer survival estimates: A EUROCARE-5 study
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Hackl, M., Zielonke, N., Van Eycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., Dušek, L., Zvolský, M., Mägi, M., Aareleid, T., Malila, N., Seppä, K., Bouvier, A.M., Faivre, J., Bossard, N., Uhry, Z., Colonna, M., Stabenow, R., Luttmann, S., Eberle, A., Brenner, H., Nennecke, A., Engel, J., Schubert-Fritschle, G., Heidrich, J., Holleczek, B., Katalinic, A., Clough-Gorr, K., Mazzoleni, G., Bulatko, A., Buzzoni, C., Giacomin, A., Ferretti, S., Barchielli, A., Caldarella, A., Gatta, G., Sant, M., Amash, H., Amati, C., Baili, P., Berrino, F., Bonfarnuzzo, S., Botta, L., Capocaccia, R., Di Salvo, F., Foschi, R., Margutti, C., Meneghini, E., Minicozzi, P., Trama, A., Serraino, D., Maso, L. Dal, De Angelis, R., Caldora, M., Carrani, E., Francisci, S., Knijn, A., Mallone, S., Pierannunzio, D., Roazzi, P., Rossi, S., Santaquilani, M., Tavilla, A., Pannozzo, F., Natali, M., Filiberti, R.A., Marani, E., Autelitano, M., Spagnoli, G., Cirilli, C., Fusco, M., Vitale, M.F., Traina, A., Staiti, R., Vitale, F., Cusimano, R., Michiara, M., Tumino, R., Falcini, F., Caiazzo, A.L., Maspero, S., Fanetti, A.C., Zanetti, R., Rosso, S., Rugge, M., Tognazzo, S., Pildava, S., Smailyte, G., Johannesen, T.B., Rachtan, J., Góźdź, S., Mężyk, R., Błaszczyk, J., Kępska, K., Bielska-Lasota, M., Forjaz de Lacerda, G., Bento, M.J., Antunes, L., Miranda, A., Mayer-da-Silva, A., Safaei Diba, C., Primic-Zakelj, M., Almar, E., Mateos, A., Lopez de Munain, A., Larrañaga, N., Torrella-Ramos, A., Díaz García, J.M., Jimenez-Chillaron, R., Marcos-Gragera, R., Vilardell, L., Moreno-Iribas, C., Ardanaz, E., Lambe, M., Mousavi, M., Bouchardy, C., Usel, M., Ess, S.M., Frick, H., Lorez, M., Herrmann, C., Bordoni, A., Spitale, A., Konzelmann, I., Visser, O., Damhuis, R., Otter, R., Coleman, M., Allemani, C., Rachet, B., Rashbass, J., Broggio, J., Verne, J., Gavin, A., Fitzpatrick, D., Huws, D.W., White, C., Minicozzi, Pamela, Innos, Kaire, Sánchez, Maria-José, Trama, Annalisa, Walsh, Paul M., Marcos-Gragera, Rafael, Dimitrova, Nadya, Botta, Laura, Visser, Otto, Rossi, Silvia, Tavilla, Andrea, and Sant, Milena
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- 2017
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11. Geographical variability in survival of European children with central nervous system tumours
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Hackl, M., Zielonke, N., Oberaigner, W., Van Eycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., Storm, H., Engholm, G., Mägi, M., Aareleid, T., Malila, N., Seppä, K., Faivre, J., Bossard, N., Uhry, Z., Colonna, M., Clavel, J., Lacour, B., Desandes, E., Brenner, H., Kaatsch, P., Katalinic, A., Garami, M., Jakab, Z., Comber, H., Mazzoleni, G., Bulatko, A., Buzzoni, C., Giacomin, A., Sutera Sardo, A., Mancuso, P., Ferretti, S., Barchielli, A., Caldarella, A., Gatta, G., Sant, M., Amash, H., Amati, C., Baili, P., Berrino, F., Bonfarnuzzo, S., Botta, L., Capocaccia, R., Di Salvo, F., Foschi, R., Margutti, C., Meneghini, E., Minicozzi, P., Trama, A., Serraino, D., Zucchetto, A., De Angelis, R., Caldora, M., Carrani, E., Francisci, S., Mallone, S., Pierannunzio, D., Roazzi, P., Rossi, S., Santaquilani, M., Tavilla, A., Pannozzo, F., Busco, S., Filiberti, R.A., Marani, E., Ricci, P., Pascucci, C., Autelitano, M., Spagnoli, G., Cirilli, C., Fusco, M., Vitale, M.F., Usala, M., Vitale, F., Ravazzolo, B., Michiara, M., Merletti, F., Maule, M., Tumino, R., Mangone, L., Di Felice, E., Falcini, F., Iannelli, A., Sechi, O., Cesaraccio, R., Piffer, S., Madeddu, A., Tisano, F., Maspero, S., Fanetti, A.C., Candela, P., Scuderi, T., Stracci, F., Bianconi, F., Tagliabue, G., Contiero, P., Rugge, M., Guzzinati, S., Pildava, S., Smailyte, G., Calleja, N., Agius, D., Johannesen, T.B., Rachtan, J., Góźdź, S., Mężyk, R., Błaszczyk, J., Bębenek, M., Bielska-Lasota, M., Forjaz de Lacerda, G., Bento, M.J., Castro, C., Miranda, A., Mayer-da-Silva, A., Safaei Diba, C., Primic-Zakelj, M., Errezola, M., Bidaurrazaga, J., Vicente Raneda, M., Díaz García, J.M., Marcos-Navarro, A.I., Marcos-Gragera, R., Izquierdo Font, A., Sanchez, M.J., Chang, D.Y.L., Navarro, C., Chirlaque, M.D., Moreno-Iribas, C., Ardanaz, E., Peris-Bonet, R., Pardo Romaguera, E., Galceran, J., Carulla, M., Lambe, M., Mousavi, M., Bouchardy, C., Usel, M., Ess, S.M., Frick, H., Lorez, M., Herrmann, C., Bordoni, A., Spitale, A., Konzelmann, I., Visser, O., Aarts, M., Otter, R., Coleman, M., Allemani, C., Rachet, B., Verne, J., Stiller, C., Gavin, A., Donnelly, C., Brewster, D.H., Sánchez, M.-J., and Rutkowski, S.
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- 2017
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12. International incidence of childhood cancer, 2001–10: a population-based registry study
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Bouzbid, S, Hamdi-Cherif, M, Hablas, A, Chirpaz, E, Buziba, N, Chesumbai, GC, Manraj, SS, Reynders, D, Wabinga, HR, Chokunonga, E, Moreno, F, Lima, CA, Asturian Laporte, C, de Oliveira, JC, de Aquino, JA Pontes, Gallagher, SM Vargas, Uribe, CJ, Bravo, LE, Yepez Chamorro, MC, Torres Alvarado, G, Galán Alvarez, YH, Martinez Reyes, FC, Castillo Calvas, JC, Mendoza Alava, M, Cueva Ayala, P, Hanchard, B, Fajardo-Gutiérrez, A, Zavala Zegarra, DE, Barrios, E, Nikiforuk, C, Woods, R, Turner, D, MacIntyre, M, Corriveau, A, Navaneelan, T, Bertrand, C, Stuart-Panko, H, Wilson, RJ, Kosary, C, Shen, X, Brockhouse, J, Yee, GA, Mitchell, TC, Snipes, K, West, D, Rao, C, Bolick, S, Rycroft, RK, Mueller, L, Zheng, Y, Dosch, K, Brown, H, Vargas, A, Levin, GM, Bayakly, R, Johnson, C, Shen, T, Ruppert, L, Lynch, CF, Lai, SM, Tucker, TC, Wu, XC, Schwenn, M, Stern, K, Gershman, S, Copeland, G, Bushhouse, S, Rogers, DB, Jackson Thompson, J, Lemons, D, Frederick, S, Harris, JA, Riddle, B, Stroup, A, Wiggins, C, Schymura, MJ, Giljahn, LK, Sheikh, A, Schubert, S, Aldinger, W, Fulton, JP, Whiteside, M, Nogueira, L, Sweeney, C, Johnson, A, Martin, J, Farley, S, Harrelson, D, Malicki, R, Espinoza, JR, Hernandez, BY, Abulfateh, N, Wang, N, Ngan, RKC, Lingegowda, KB, Swaminathan, R, Koyande, SS, Silverman, B, Ozasa, K, Kanemura, S, Soda, M, Miyashiro, I, Shibata, A, Nimri, O, Won, YJ, Kim, CH, Hong, NS, Nam, HS, Kweon, S, Kim, WC, Huh, JS, Jung, KW, Yoo, CI, Elbasmy, A, Laudico, AV, Lumague, MR, AlMutlag, H, Buasom, R, Srisukho, S, Tanabodee, J, Wiangnon, S, Pongnikorn, D, Sriplung, H, Dirican, O, Eser, S, Le Hoang, M, Hackl, M, Zborovskaya, A, Dimitrova, N, Valerianova, Z, Sekerija, M, Pavlou, P, Dušek, M, Mägi, M, Clavel, J, Lacour, B, Guizard, AV, Bouvier, V, Troussard, X, Woronoff, AS, Tretarre, B, Colonna, M, Molinié, F, Bara, S, Velten, M, Marrer, E, Ganry, O, Grosclaude, P, Kaatsch, P, Zeissig, SR, Holleczek, B, Katalinic, A, Jakab, Z, Birgisson, H, Walsh, PM, Mangone, L, Merletti, F, Magoni, M, Ferretti, S, Serraino, D, Spagnoli, G, Fusco, M, Michiara, M, Tumino, R, Falcini, F, Sensi, F, Tisano, F, Piffer, S, Stracci, F, Tagliabue, G, Smailyte, G, Agius, D, Visser, O, Ursin, G, Didkowska, J, Trojanowski, M, Wojciechowska, U, Forjaz de Lacerda, G, Silva, MA, Laranja Pontes, J, da Costa Miranda, A, Kaiserova, E, Primic Žakelj, M, Peris-Bonet, R, Vicente Raneda, ML, Almar Marqués, E, Quirós Garcia, JR, Ramos Monserrat, M, Errezola Saizar, M, Alemán Herrera, A, Díaz García, JM, Marcos-Gragera, R, Sanchez-Perez, MJ, Ardanaz Aicua, E, Galceran, J, Klint, A, Kuehni, CE, Bouchardy, C, Levi, F, Bordoni, A, Konzelmann, I, Rohrmann, S, Stiller, CA, Gavin, AT, Brewster, DH, Phung, H, Rushton, S, Guthridge, S, Aitken, J, D'Onise, K, Venn, A, Farrugian, H, Threlfall, TJ, Laumond, S, Yen Kai Sun, L, Hendrix, J, Ballantine, K, Colombet, M, Dolya, A, Masuyer, E, Steliarova-Foucher, E, Steliarova-Foucher, Eva, Colombet, Murielle, Ries, Lynn A G, Moreno, Florencia, Dolya, Anastasia, Bray, Freddie, Hesseling, Peter, Shin, Hee Young, and Stiller, Charles A
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- 2017
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13. Survival of 86,690 patients with thyroid cancer: A population-based study in 29 European countries from EUROCARE-5
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Hackl, M., Zielonke, N., Van Eycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., Dušek, L., Zvolský, M., Storm, H., Engholm, G., Mägi, M., Aareleid, T., Malila, N., Seppä, K., Velten, M., Guizard, A.V., Faivre, J., Woronoff, A.S., Tretarre, B., Bossard, N., Uhry, Z., Colonna, M., Molinié, F., Bara, S., Schvartz, C., Lapôtre-Ledoux, B., Grosclaude, P., Stabenow, R., Luttmann, S., Eberle, A., Brenner, H., Nennecke, A., Engel, J., Schubert-Fritschle, G., Heidrich, J., Holleczek, B., Katalinic, A., Jónasson, J.G., Tryggvadóttir, L., Comber, H., Mazzoleni, G., Bulatko, A., Buzzoni, C., Giacomin, A., Sutera Sardo, A., Mazzei, A., Ferretti, S., Barchielli, A., Caldarella, A., Gatta, G., Sant, M., Amash, H., Amati, C., Baili, P., Berrino, F., Bonfarnuzzo, S., Botta, L., Capocaccia, R., Di Salvo, F., Foschi, R., Margutti, C., Meneghini, E., Minicozzi, P., Trama, A., Serraino, D., Zucchetto, A., De Angelis, R., Caldora, M., Carrani, E., Francisci, S., Mallone, S., Pierannunzio, D., Roazzi, P., Rossi, S., Santaquilani, M., Tavilla, A., Pannozzo, F., Busco, S., Filiberti, R.A., Vercelli, M., Ricci, P., Autelitano, M., Spagnoli, G., Cirilli, C., Fusco, M., Vitale, M.F., Usala, M., Vitale, F., Ravazzolo, B., Michiara, M., Tumino, R., Mangone, L., Vicentini, M., Falcini, F., Iannelli, A., Sechi, O., Cesaraccio, R., Piffer, S., Madeddu, A., Tisano, F., Maspero, S., Fanetti, A.C., Zanetti, R., Rosso, S., Candela, P., Scuderi, T., Stracci, F., Rocca, A., Tagliabue, G., Contiero, P., Rugge, M., Tognazzo, S., Pildava, S., Smailyte, G., Calleja, N., Agius, D., Johannesen, T.B., Rachtan, J., Góźdź, S., Mężyk, R., Błaszczyk, J., Bębenek, M., Bielska-Lasota, M., Forjaz de Lacerda, G., Bento, M.J., Castro, C., Miranda, A., Mayer-da-Silva, A., Safaei Diba, C., Primic-Zakelj, M., Errezola, M., Bidaurrazaga, J., Díaz García, J.M., Marcos-Navarro, A.I., Marcos-Gragera, R., Izquierdo Font, A., Sanchez, M.J., Molina, E., Navarro, C., Chirlaque, M.D., Moreno-Iribas, C., Ardanaz, E., Galceran, J., Carulla, M., Lambe, M., Khan, S., Mousavi, M., Bouchardy, C., Usel, M., Ess, S.M., Frick, H., Lorez, M., Herrmann, C., Bordoni, A., Spitale, A., Konzelmann, I., Visser, O., Ho, V., Otter, R., Coleman, M., Allemani, C., Rachet, B., Rashbass, J., Broggio, J., Verne, J., Gavin, A., Donnelly, C., Brewster, D.H., Huws, D.W., White, C., Dal Maso, L., Pacini, F., van Dijk, B.A.C., Larrañaga, N., Rubió-Casadevall, J., Kowalska, A., and Virdone, S.
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- 2017
- Full Text
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14. Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries
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Bouzbid, S, Hamdi-Chérif, M, Zaidi, Z, Bah, E, Swaminathan, R, Nortje, SH, El Mistiri, MM, Bayo, S, Malle, B, Manraj, SS, Sewpaul-Sungkur, R, Fabowale, Ogunbiyi, OJ, Bradshaw, D, Somdyala, NIM, Stefan, DC, Abdel-Rahman, M, Jaidane, L, Mokni, M, Kumcher, I, Moreno, F, González, MS, Laura, EA, Espinola, SB, Calabrano, GH, Carballo Quintero, B, Fita, R, Garcilazo, DA, Giacciani, PL, Diumenjo, MC, Laspada, WD, Green, MA, Lanza, MF, Ibañez, SG, Lima, CA, de Oliveira, E Lobo, Daniel, C, Scandiuzzi, C, De Souza, PCF, Melo, CD, Del Pino, K, Laporte, C, Curado, MP, de Oliveira, JC, Veneziano, CLA, Veneziano, DB, Azevedo e Silva, G, Galaz, JC, Moya, JA, Herrmann, DA, Vargas, S, Herrera, VM, Uribe, CJ, Bravo, LE, Arias-Ortiz, NE, Jurado, DM, Yépez, MC, Galán, YH, Torres, P, Martínez-Reyes, F, Pérez-Meza, ML, Jaramillo, L, Quinto, R, Cueva, P, Yépez, JG, Torres-Cintrón, CR, Tortolero-Luna, G, Alonso, R, Barrios, E, Nikiforuk, C, Shack, L, Coldman, AJ, Woods, RR, Noonan, G, Turner, D, Kumar, E, Zhang, B, McCrate, FR, Ryan, S, Hannah, H, Dewar, RAD, MacIntyre, M, Lalany, A, Ruta, M, Marrett, L, Nishri, DE, McClure, C, Vriends, KA, Bertrand, C, Louchini, R, Robb, KI, Stuart-Panko, H, Demers, S, Wright, S, George, JT, Shen, X, Brockhouse, JT, O'Brien, DK, Ward, KC, Almon, L, Bates, J, Rycroft, R, Mueller, L, Phillips, C, Brown, H, Cromartie, B, Schwartz, AG, Vigneau, F, MacKinnon, JA, Wohler, B, Bayakly, AR, Clarke, CA, Glaser, SL, West, D, Green, MD, Hernandez, BY, Johnson, CJ, Jozwik, D, Charlton, ME, Lynch, CF, Huang, B, Tucker, TC, Deapen, D, Liu, L, Hsieh, MC, Wu, XC, Stern, K, Gershman, ST, Knowlton, RC, Alverson, J, Copeland, GE, Rogers, DB, Lemons, D, Williamson, LL, Hood, M, Hosain, GM, Rees, JR, Pawlish, KS, Stroup, A, Key, C, Wiggins, C, Kahn, AR, Schymura, MJ, Leung, G, Rao, C, Giljahn, L, Warther, B, Pate, A, Patil, M, Schubert, SS, Rubertone, JJ, Slack, SJ, Fulton, JP, Rousseau, DL, Janes, TA, Schwartz, SM, Bolick, SW, Hurley, DM, Richards, J, Whiteside, MA, Nogueira, LM, Herget, K, Sweeney, C, Martin, J, Wang, S, Harrelson, DG, Cheteri, MB Keitheri, Farley, S, Hudson, AG, Borchers, R, Stephenson, L, Espinoza, JR, Weir, HK, Edwards, BK, Wang, N, Yang, L, Chen, JS, Song, GH, Gu, XP, Zhang, P, Ge, HM, Zhao, DL, Zhang, JH, Zhu, FD, Tang, JG, Shen, Y, Wang, J, Li, QL, Yang, XP, Dong, J, Li, W, Cheng, LP, Chen, JG, Huang, QH, Huang, SQ, Guo, GP, Wei, K, Chen, WQ, Zeng, H, Demetriou, AV, Pavlou, P, Mang, WK, Ngan, KC, Kataki, AC, Krishnatreya, M, Jayalekshmi, PA, Sebastian, P, Sapkota, SD, Verma, Y, Nandakumar, A, Suzanna, E, Keinan-Boker, L, Silverman, BG, Ito, H, Nakagawa, H, Hattori, M, Kaizaki, Y, Sugiyama, H, Utada, M, Katayama, K, Narimatsu, H, Kanemura, S, Koike, T, Miyashiro, I, Yoshii, M, Oki, I, Shibata, A, Matsuda, T, Nimri, O, Ab Manan, A, Pathy, N Bhoo, Chimedsuren, O, Tuvshingerel, S, Al Khater, AHM, Al-Eid, H, Jung, KW, Won, YJ, Chiang, CJ, Lai, MS, Suwanrungruang, K, Wiangnon, S, Daoprasert, K, Pongnikorn, D, Geater, SL, Sriplung, H, Eser, S, Yakut, CI, Hackl, M, Mühlböck, H, Oberaigner, W, Zborovskaya, AA, Aleinikova, OV, Henau, K, Van Eycken, L, Dimitrova, N, Valerianova, Z, Šekerija, M, Zvolský, M, Engholm, G, Storm, H, Innos, K, Mägi, M, Malila, N, Seppä, K, Jégu, J, Velten, M, Cornet, E, Troussard, X, Bouvier, AM, Faivre, J, Guizard, AV, Bouvier, V, Launoy, G, Arveux, P, Maynadié, M, Mounier, M, Fournier, E, Woronoff, AS, Daoulas, M, Clavel, J, Le Guyader-Peyrou, S, Monnereau, A, Trétarre, B, Colonna, M, Cowppli-Bony, A, Molinié, F, Bara, S, Degré, D, Ganry, O, Lapôtre-Ledoux, B, Grosclaude, P, Estève, J, Bray, F, Piñeros, M, Sassi, F, Stabenow, R, Eberle, A, Erb, C, Nennecke, A, Kieschke, J, Sirri, E, Kajueter, H, Emrich, K, Zeissig, SR, Holleczek, B, Eisemann, N, Katalinic, A, Brenner, H, Asquez, RA, Kumar, V, Ólafsdóttir, EJ, Tryggvadóttir, L, Comber, H, Walsh, PM, Sundseth, H, Devigili, E, Mazzoleni, G, Giacomin, A, Bella, F, Castaing, M, Sutera, A, Gola, G, Ferretti, S, Serraino, D, Zucchetto, A, Lillini, R, Vercelli, M, Busco, S, Pannozzo, F, Vitarelli, S, Ricci, P, Pascucci, C, Autelitano, M, Cirilli, C, Federico, M, Fusco, M, Vitale, MF, Usala, M, Cusimano, R, Mazzucco, W, Michiara, M, Sgargi, P, Maule, MM, Sacerdote, C, Tumino, R, Di Felice, E, Vicentini, M, Falcini, F, Cremone, L, Budroni, M, Cesaraccio, R, Contrino, ML, Tisano, F, Fanetti, AC, Maspero, S, Candela, G, Scuderi, T, Gentilini, MA, Piffer, S, Rosso, S, Sacchetto, L, Caldarella, A, La Rosa, F, Stracci, F, Contiero, P, Tagliabue, G, Dei Tos, AP, Zorzi, M, Zanetti, R, Baili, P, Berrino, F, Gatta, G, Sant, M, Capocaccia, R, De Angelis, R, Liepina, E, Maurina, A, Smailyte, G, Agius, D, Calleja, N, Siesling, S, Visser, O, Larønningen, S, Møller, B, Dyzmann-Sroka, A, Trojanowski, M, Gózdz, S, Mezyk, R, Gradalska-Lampart, M, Radziszewska, AU, Didkowska, JA, Wojciechowska, U, Blaszczyk, J, Kepska, K, Bielska-Lasota, M, Kwiatkowska, K, Forjaz, G, Rego, RA, Bastos, J, Silva, MA, Antunes, L, Bento, MJ, Mayer-da-Silva, A, Miranda, A, Coza, D, Todescu, AI, Valkov, MY, Adamcik, J, Safaei Diba, C, Primic-Žakelj, M, Žagar, T, Stare, J, Almar, E, Mateos, A, Quirós, JR, Bidaurrazaga, J, Larrañaga, N, Díaz García, JM, Marcos, AI, Marcos-Gragera, R, Vilardell Gil, ML, Molina, E, Sánchez, MJ, Sureda, P Franch, Montserrat, M Ramos, Chirlaque, MD, Navarro, C, Ardanaz, EE, Moreno-Iribas, CC, Fernández-Delgado, R, Peris-Bonet, R, Galceran, J, Khan, S, Lambe, M, Camey, B, Bouchardy, C, Usel, M, Ess, SM, Herrmann, C, Bulliard, JL, Maspoli-Conconi, M, Frick, H, Kuehni, CE, Schindler, M, Bordoni, A, Spitale, A, Chiolero, A, Konzelmann, I, Dehler, SI, Matthes, KL, Rashbass, J, Stiller, CA, Fitzpatrick, D, Gavin, A, Bannon, F, Black, RJ, Brewster, DH, Huws, DW, White, C, Finan, P, Allemani, C, Bonaventure, A, Carreira, H, Coleman, MP, Di Carlo, V, Harewood, R, Liu, K, Matz, M, Montel, L, Nikšić, M, Rachet, B, Sanz, N, Spika, D, Stephens, R, Peake, M, Murphy, MFG, Chalker, E, Newman, L, Baker, D, Soeberg, MJ, Aitken, J, Scott, C, Stokes, BC, Venn, A, Farrugia, H, Giles, GG, Threlfall, T, Currow, D, You, H, Hendrix, J, Lewis, C, Latorre, MRDO, Tanaka, LF, Bonaventure, Audrey, Harewood, Rhea, Stiller, Charles A, Gatta, Gemma, Clavel, Jacqueline, Stefan, Daniela C, Carreira, Helena, Spika, Devon, Marcos-Gragera, Rafael, Peris-Bonet, Rafael, Piñeros, Marion, Sant, Milena, Kuehni, Claudia E, Murphy, Michael F G, Coleman, Michel P, and Allemani, Claudia
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- 2017
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15. The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2)
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Bouzbid, S., Hamdi-Chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S.H., Stefan, D.C., El Mistiri, M.M., Bayo, S., Malle, B., Manraj, S.S., Sewpaul-Sungkur, R., Fabowale, A., Ogunbiyi, O.J., Bradshaw, D., Somdyala, N.I.M., Abdel-Rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M.S., Laura, E.A., Espinola, S.B., Calabrano, G.H., Carballo Quintero, B., Fita, R., Garcilazo, D.A., Giacciani, P.L., Diumenjo, M.C., Laspada, W.D., Green, M.A., Lanza, M.F., Ibañez, S.G., Lima, C.A., Lobo de Oliveira, E., Daniel, C., Scandiuzzi, C., De Souza, P.C.F., Melo, C.D., Del Pino, K., Laporte, C., Curado, M.P., de Oliveira, J.C., Veneziano, C.L.A., Veneziano, D.B., Alexandre, T.S., Verdugo, A.S., Azevedo e Silva, G., Galaz, J.C., Moya, J.A., Herrmann, D.A., Vargas, S., Herrera, V.M., Uribe, C.J., Bravo, L.E., Arias-Ortiz, N.E., Jurado, D.M., Yépez, M.C., Galán, Y.H., Torres, P., Martínez-Reyes, F., Pérez-Meza, M.L., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J.G., Torres-Cintrón, C.R., Tortolero-Luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A.J., Woods, R.R., Noonan, G., Turner, D., Kumar, E., Zhang, B., McCrate, F.R., Ryan, S., Hannah, H., Dewar, R.A.D., MacIntyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D.E., McClure, C., Vriends, K.A., Bertrand, C., Louchini, R., Robb, K.I., Stuart-Panko, H., Demers, S., Wright, S., George, J.T., Shen, X., Brockhouse, J.T., O'Brien, D.K., Ward, K.C., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A.G., Vigneau, F., MacKinnon, J.A., Wohler, B., Bayakly, A.R., Clarke, C.A., Glaser, S.L., West, D., Green, M.D., Hernandez, B.Y., Johnson, C.J., Jozwik, D., Charlton, M.E., Lynch, C.F., Huang, B., Tucker, T.C., Deapen, D., Liu, L., Hsieh, M.C., Wu, X.C., Stern, K., Gershman, S.T., Knowlton, R.C., Alverson, J., Copeland, G.E., Rogers, D.B., Lemons, D., Williamson, L.L., Hood, M., Hosain, G.M., Rees, J.R., Pawlish, K.S., Stroup, A., Key, C., Wiggins, C., Kahn, A.R., Schymura, M.J., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S.S., Rubertone, J.J., Slack, S.J., Fulton, J.P., Rousseau, D.L., Janes, T.A., Schwartz, S.M., Bolick, S.W., Hurley, D.M., Richards, J., Whiteside, M.A., Nogueira, L.M., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D.G., Keitheri Cheteri, M.B., Farley, S., Hudson, A.G., Borchers, R., Stephenson, L., Espinoza, J.R., Weir, H.K., Edwards, B.K., Wang, N., Yang, L., Chen, J.S., Song, G.H., Gu, X.P., Zhang, P., Ge, H.M., Zhao, D.L., Zhang, J.H., Zhu, F.D., Tang, J.G., Shen, Y., Wang, J., Li, Q.L., Yang, X.P., Dong, J., Li, W., Cheng, L.P., Chen, J.G., Huang, Q.H., Huang, S.Q., Guo, G.P., Wei, K., Chen, W.Q., Zeng, H., Demetriou, A.V., Pavlou, P., Mang, W.K., Ngan, K.C., Kataki, A.C., Krishnatreya, M., Jayalekshmi, P.A., Sebastian, P., Sapkota, S.D., Verma, Y., Nandakumar, A., Suzanna, E., Keinan-Boker, L., Silverman, B.G., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Bhoo Pathy, N., Chimedsuren, O., Tuvshingerel, S., Al Khater, A.H.M., Al-Eid, H., Jung, K.W., Won, Y.J., Chiang, C.J., Lai, M.S., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S.L., Sriplung, H., Eser, S., Yakut, C.I., Hackl, M., Mühlböck, H., Oberaigner, W., Zborovskaya, A.A., Aleinikova, O.V., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Šekerija, M., Zvolský, M., Engholm, G., Storm, H., Innos, K., Mägi, M., Malila, N., Seppä, K., Jégu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A.M., Faivre, J., Guizard, A.V., Bouvier, V., Launoy, G., Arveux, P., Maynadié, M., Mounier, M., Fournier, E., Woronoff, A.S., Daoulas, M., Clavel, J., Le Guyader-Peyrou, S., Monnereau, A., Trétarre, B., Colonna, M., Cowppli-Bony, A., Molinié, F., Bara, S., Degré, D., Ganry, O., Lapôtre-Ledoux, B., Grosclaude, P., Estève, J., Bray, F., Piñeros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S.R., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R.A., Kumar, V., Ólafsdóttir, E.J., Tryggvadóttir, L., Comber, H., Walsh, P.M., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, M., Vitale, M.F., Usala, M., Cusimano, R., Mazzucco, W., Michiara, M., Sgargi, P., Maule, M.M., Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M.L., Tisano, F., Fanetti, A.C., Maspero, S., Candela, G., Scuderi, T., Gentilini, M.A., Piffer, S., Rosso, S., Sacchetto, L., Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A.P., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Gatta, G., Sant, M., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Visser, O., Larønningen, S., Møller, B., Dyzmann-Sroka, A., Trojanowski, M., Góźdż, S., Mężyk, R., Grądalska-Lampart, M., Radziszewska, A.U., Didkowska, J.A., Wojciechowska, U., Błaszczyk, J., Kępska, K., Bielska-Lasota, M., Kwiatkowska, K., Forjaz, G., Rego, R.A., Bastos, J., Silva, M.A., Antunes, L., Bento, M.J., Mayer-da-Silva, A., Miranda, A., Coza, D., Todescu, A.I., Valkov, M.Y., Adamcik, J., Safaei Diba, C., Primic-Žakelj, M., Žagar, T., Stare, J., Almar, E., Mateos, A., Quirós, J.R., Bidaurrazaga, J., Larrañaga, N., Díaz García, J.M., Marcos, A.I., Marcos-Gragera, R., Vilardell Gil, M.L., Molina, E., Sánchez, M.J., Franch Sureda, P., Ramos Montserrat, M., Chirlaque, M.D., Navarro, C., Ardanaz, E.E., Moreno-Iribas, C.C., Fernández-Delgado, R., Peris-Bonet, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S.M., Herrmann, C., Bulliard, J.L., Maspoli-Conconi, M., Frick, H., Kuehni, C.E., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S.I., Matthes, K.L., Rashbass, J., Stiller, C., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R.J., Brewster, D.H., Huws, D.W., White, C., Finan, P., Allemani, C., Bonaventure, A., Carreira, H., Coleman, M.P., Di Carlo, V., Harewood, R., Liu, K., Matz, M., Montel, L., Nikšić, M., Rachet, B., Sanz, N., Spika, D., Stephens, R., Peake, M., Chalker, E., Newman, L., Baker, D., Soeberg, M.J., Aitken, J., Scott, C., Stokes, B.C., Venn, A., Farrugia, H., Giles, G.G., Threlfall, T., Currow, D., You, H., Hendrix, J., Lewis, C., Matz, Melissa, Coleman, Michel P, Sant, Milena, Chirlaque, Maria Dolores, Visser, Otto, Gore, Martin, and Allemani, Claudia
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- 2017
- Full Text
- View/download PDF
16. Worldwide comparison of ovarian cancer survival: Histological group and stage at diagnosis (CONCORD-2)
- Author
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Bouzbid, S., Hamdi-Chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S.H., El Mistiri, M.M., Bayo, S., Malle, B., Manraj, S.S., Sewpaul-Sungkur, R., Fabowale, A., Ogunbiyi, O.J., Bradshaw, D., Somdyala, N.I.M., Stefan, D.C., Abdel-Rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M.S., Laura, E.A., Espinola, S.B., Calabrano, G.H., Carballo Quintero, B., Fita, R., Garcilazo, D.A., Giacciani, P.L., Diumenjo, M.C., Laspada, W.D., Green, M.A., Lanza, M.F., Ibañez, S.G., Lima, C.A., Lobo de Oliveira, E., Daniel, C., Scandiuzzi, C., De Souza, P.C.F., Melo, C.D., Del Pino, K., Laporte, C., Curado, M.P., de Oliveira, J.C., Veneziano, C.L.A., Veneziano, D.B., Latorre, M.R.D.O., Tanaka, L.F., Azevedo e Silva, G., Galaz, J.C., Moya, J.A., Herrmann, D.A., Vargas, S., Herrera, V.M., Uribe, C.J., Bravo, L.E., Arias-Ortiz, N.E., Jurado, D.M., Yépez, M.C., Galán, Y.H., Torres, P., Martínez-Reyes, F., Pérez-Meza, M.L., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J.G., Torres-Cintrón, C.R., Tortolero-Luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A.J., Woods, R.R., Noonan, G., Turner, D., Kumar, E., Zhang, B., McCrate, F.R., Ryan, S., Hannah, H., Dewar, R.A.D., MacIntyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D.E., McClure, C., Vriends, K.A., Bertrand, C., Louchini, R., Robb, K.I., Stuart-Panko, H., Demers, S., Wright, S., George, J.T., Shen, X., Brockhouse, J.T., O'Brien, D.K., Ward, K.C., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A.G., Vigneau, F., MacKinnon, J.A., Wohler, B., Bayakly, A.R., Clarke, C.A., Glaser, S.L., West, D., Green, M.D., Hernandez, B.Y., Johnson, C.J., Jozwik, D., Charlton, M.E., Lynch, C.F., Huang, B., Tucker, T.C., Deapen, D., Liu, L., Hsieh, M.C., Wu, X.C., Stern, K., Gershman, S.T., Knowlton, R.C., Alverson, J., Copeland, G.E., Rogers, D.B., Lemons, D., Williamson, L.L., Hood, M., Hosain, G.M., Rees, J.R., Pawlish, K.S., Stroup, A., Key, C., Wiggins, C., Kahn, A.R., Schymura, M.J., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S.S., Rubertone, J.J., Slack, S.J., Fulton, J.P., Rousseau, D.L., Janes, T.A., Schwartz, S.M., Bolick, S.W., Hurley, D.M., Richards, J., Whiteside, M.A., Nogueira, L.M., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D.G., Keitheri Cheteri, M.B., Farley, S., Hudson, A.G., Borchers, R., Stephenson, L., Espinoza, J.R., Weir, H.K., Edwards, B.K., Wang, N., Yang, L., Chen, J.S., Song, G.H., Gu, X.P., Zhang, P., Ge, H.M., Zhao, D.L., Zhang, J.H., Zhu, F.D., Tang, J.G., Shen, Y., Wang, J., Li, Q.L., Yang, X.P., Dong, J., Li, W., Cheng, L.P., Chen, J.G., Huang, Q.H., Huang, S.Q., Guo, G.P., Wei, K., Chen, W.Q., Zeng, H., Demetriou, A.V., Pavlou, P., Mang, W.K., Ngan, K.C., Kataki, A.C., Krishnatreya, M., Jayalekshmi, P.A., Sebastian, P., Sapkota, S.D., Verma, Y., Nandakumar, A., Suzanna, E., Keinan-Boker, L., Silverman, B.G., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Bhoo-Pathy, N., Tuvshingerel, S., Chimedsuren, O., Al Khater, A.H.M., Al-Eid, H., Jung, K.W., Won, Y.J., Chiang, C.J., Lai, M.S., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S.L., Sriplung, H., Eser, S., Yakut, C.I., Hackl, M., Mühlböck, H., Oberaigner, W., Zborovskaya, A.A., Aleinikova, O.V., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Šekerija, M., Zvolský, M., Engholm, G., Storm, H., Innos, K., Mägi, M., Malila, N., Seppä, K., Jégu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A.M., Faivre, J., Guizard, A.V., Bouvier, V., Launoy, G., Arveux, P., Maynadié, M., Mounier, M., Fournier, E., Woronoff, A.S., Daoulas, M., Clavel, J., Le Guyader-Peyrou, S., Monnereau, A., Trétarre, B., Colonna, M., Cowppli-Bony, A., Molinié, F., Bara, S., Degré, D., Ganry, O., Lapôtre-Ledoux, B., Grosclaude, P., Estève, J., Bray, F., Piñeros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S.R., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R.A., Kumar, V., Ólafsdóttir, E.J., Tryggvadóttir, L., Comber, H., Walsh, P.M., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, M., Vitale, M.F., Usala, M., Cusimano, R., Mazzucco, W., Michiara, M., Sgargi, P., Maule, M.M., Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M.L., Tisano, F., Fanetti, A.C., Maspero, S., Candela, G., Scuderi, T., Gentilini, M.A., Piffer, S., Rosso, S., Sacchetto, L., Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A.P., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Gatta, G., Sant, M., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Visser, O., Larønningen, S., Møller, B., Dyzmann-Sroka, A., Trojanowski, M., Góźdż, S., Mężyk, R., Grądalska-Lampart, M., Radziszewska, A.U., Didkowska, J.A., Wojciechowska, U., Błaszczyk, J., Kępska, K., Bielska-Lasota, M., Kwiatkowska, K., Forjaz, G., Rego, R.A., Bastos, J., Silva, M.A., Antunes, L., Bento, M.J., Mayer-da-Silva, A., Miranda, A., Coza, D., Todescu, A.I., Valkov, M.Y., Adamcik, J., Safaei Diba, C., Primic-Žakelj, M., Žagar, T., Stare, J., Almar, E., Mateos, A., Quirós, J.R., Bidaurrazaga, J., Larrañaga, N., Díaz García, J.M., Marcos, A.I., Marcos-Gragera, R., Vilardell Gil, M.L., Molina, E., Sánchez, M.J., Franch Sureda, P., Ramos Montserrat, M., Chirlaque, M.D., Navarro, C., Ardanaz, E.E., Moreno-Iribas, C.C., Fernández-Delgado, R., Peris-Bonet, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S.M., Herrmann, C., Bulliard, J.L., Maspoli-Conconi, M., Frick, H., Kuehni, C.E., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S.I., Matthes, K.L., Rashbass, J., Stiller, C.A., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R.J., Brewster, D.H., Huws, D.W., White, C., Finan, P., Allemani, C., Bonaventure, A., Carreira, H., Coleman, M.P., Di Carlo, V., Harewood, R., Liu, K., Matz, M., Montel, L., Nikšić, M., Rachet, B., Sanz, N., Spika, D., Stephens, R., Peake, M., Chalker, E., Newman, L., Baker, D., Soeberg, M.J., Aitken, J., Scott, C., Stokes, B.C., Venn, A., Farrugia, H., Giles, G.G., Threlfall, T., Currow, D., You, H., Hendrix, J., Lewis, C., Matz, Melissa, Coleman, Michel P, Carreira, Helena, Salmerón, Diego, Chirlaque, Maria Dolores, and Allemani, Claudia
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- 2017
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17. Smoking and Hematolymphopoietic Malignancies
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Stagnaro, E., Ramazzotti, V., Crosignani, P., Fontana, A., Masala, G., Miligi, L., Nanni, O., Neri, M., Rodella, S., Costantini, A. Seniori, Tumino, R., Viganò, C., Vindigni, C., and Vineis, P.
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- 2001
18. A body shape index (ABSI) is associated inversely with post-menopausal progesterone-receptor-negative breast cancer risk in a large European cohort
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Christakoudi, S, Tsilidis, KK, Dossus, L, Rinaldi, S, Weiderpass, E, Antoniussen, CS, Dahm, CC, Tjønneland, A, Mellemkjær, L, Katzke, V, Kaaks, R, Schulze, MB, Masala, G, Grioni, S, Panico, S, Tumino, R, Sacerdote, C, May, AM, Monninkhof, EM, Quirós, JR, Bonet, C, Sánchez, M-J, Amiano, P, Chirlaque, M-D, Guevara, M, Rosendahl, AH, Stocks, T, Perez-Cornago, A, Tin Tin, S, Heath, AK, Aglago, EK, Peruchet-Noray, L, Freisling, H, and Riboli, E
- Subjects
Breast Neoplasms/complications ,Somatotypes ,Hip Size ,Triple Negative Breast Neoplasms/complications ,Waist Size ,Middle Aged ,Body Mass Index ,Postmenopause ,ABSI ,Body shape ,Breast cancer ,Risk Factors ,Humans ,Female ,Prospective Studies ,Obesity ,Progesterone - Abstract
BACKGROUND: Associations of body shape with breast cancer risk, independent of body size, are unclear because waist and hip circumferences are correlated strongly positively with body mass index (BMI).METHODS: We evaluated body shape with the allometric "a body shape index" (ABSI) and hip index (HI), which compare waist and hip circumferences, correspondingly, among individuals with the same weight and height. We examined associations of ABSI, HI, and BMI (per one standard deviation increment) with breast cancer overall, and according to menopausal status at baseline, age at diagnosis, and oestrogen and progesterone receptor status (ER+/-PR+/-) in multivariable Cox proportional hazards models using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.RESULTS: During a mean follow-up of 14.0 years, 9011 incident breast cancers were diagnosed among 218,276 women. Although there was little evidence for association of ABSI with breast cancer overall (hazard ratio HR = 0.984; 95% confidence interval: 0.961-1.007), we found borderline inverse associations for post-menopausal women (HR = 0.971; 0.942-1.000; n = 5268 cases) and breast cancers diagnosed at age ≥ 55 years (HR = 0.976; 0.951-1.002; n = 7043) and clear inverse associations for ER + PR- subtypes (HR = 0.894; 0.822-0.971; n = 726) and ER-PR- subtypes (HR = 0.906; 0.835-0.983 n = 759). There were no material associations with HI. BMI was associated strongly positively with breast cancer overall (HR = 1.074; 1.049-1.098), for post-menopausal women (HR = 1.117; 1.085-1.150), for cancers diagnosed at age ≥ 55 years (HR = 1.104; 1.076-1.132), and for ER + PR + subtypes (HR = 1.122; 1.080-1.165; n = 3101), but not for PR- subtypes.CONCLUSIONS: In the EPIC cohort, abdominal obesity evaluated with ABSI was not associated with breast cancer risk overall but was associated inversely with the risk of post-menopausal PR- breast cancer. Our findings require validation in other cohorts and with a larger number of PR- breast cancer cases.
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- 2023
19. SEROLOGIC MARKERS OF CHLAMYDIA TRACHOMATIS AND OTHER SEXUALLY TRANSMITTED INFECTIONS AND SUBSEQUENT OVARIAN CANCER RISK: RESULTS FROM THE EPIC COHORT: EP874
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Idahl, A, Le Cornet, C, Maldonado, González S, Waterboer, T, Bender, N, Tjønneland, A, Hansen, L, Boutron-Ruault, M-C, Fournier, A, Kvaskoff, M, Boeing, H, Trichopoulou, A, Valanou, E, Peppa, E, Palli, D, Agnoli, C, Mattiello, A, Tumino, R, Sacerdote, C, Onland-Moret, C, Gram, I T, Weiderpass, E, Quirós, J R, Duell, E J, Sánchez, M-J, Chirlaque, M-D, Barricarte, A, Gil, L, Brändstedt, J, Riesbeck, K, Lundin, E, Khaw, K-T, Perez-Cornago, A, Gunter, M, Dossus, L, Kaaks, R, and Fortner, Turzanski R
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- 2019
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20. Late Mortality, Subsequent Malignant Neoplasms and Hospitalisations in Long-Term Survivors of Adolescent and Young Adult Hematological Cancers
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Trama, A, Vener, C, Lasalvia, P, Bernasconi, A, Zorzi, M, Andreano, A, Contiero, P, Manneschi, G, Falcini, F, Castaing, M, Filiberti, R, Gasparotti, C, Cirilli, C, Amodio, R, Bisceglia, I, Iacovacci, S, Vitale, M, Stracci, F, Gentilini, M, Tumino, R, Carone, S, Sampietro, G, Melcarne, A, Gatti, L, Boschetti, L, Corti, M, Rognoni, M, Coviello, E, Pesce, M, D'Orsi, G, Fanetti, A, De Lorenzis, L, Candela, G, Savoia, F, Pascucci, C, Castelli, M, Storchi, C, Trama A., Vener C., Lasalvia P., Bernasconi A., Zorzi M., Andreano A., Contiero P., Manneschi G., Falcini F., Castaing M., Filiberti R. A., Gasparotti C., Cirilli C., Amodio R., Bisceglia I., Iacovacci S., Vitale M. F., Stracci F., Gentilini M. A., Tumino R., Carone S., Sampietro G., Melcarne A., Gatti L., Boschetti L., Corti M., Rognoni M., Coviello E., Pesce M. T., D'Orsi G., Fanetti A. C., De Lorenzis L., Candela G., Savoia F., Pascucci C., Castelli M., Storchi C., Trama, A, Vener, C, Lasalvia, P, Bernasconi, A, Zorzi, M, Andreano, A, Contiero, P, Manneschi, G, Falcini, F, Castaing, M, Filiberti, R, Gasparotti, C, Cirilli, C, Amodio, R, Bisceglia, I, Iacovacci, S, Vitale, M, Stracci, F, Gentilini, M, Tumino, R, Carone, S, Sampietro, G, Melcarne, A, Gatti, L, Boschetti, L, Corti, M, Rognoni, M, Coviello, E, Pesce, M, D'Orsi, G, Fanetti, A, De Lorenzis, L, Candela, G, Savoia, F, Pascucci, C, Castelli, M, Storchi, C, Trama A., Vener C., Lasalvia P., Bernasconi A., Zorzi M., Andreano A., Contiero P., Manneschi G., Falcini F., Castaing M., Filiberti R. A., Gasparotti C., Cirilli C., Amodio R., Bisceglia I., Iacovacci S., Vitale M. F., Stracci F., Gentilini M. A., Tumino R., Carone S., Sampietro G., Melcarne A., Gatti L., Boschetti L., Corti M., Rognoni M., Coviello E., Pesce M. T., D'Orsi G., Fanetti A. C., De Lorenzis L., Candela G., Savoia F., Pascucci C., Castelli M., and Storchi C.
- Abstract
Background: Increased success in the treatment of hematological cancers contributed to the increase of 5-year survival for most adolescent and young adults (AYAs) with these tumours. However, as 5-year survival increased, it became clear that AYA long-term survivors were at increased risk for severe late effects. Moreover, limited information on long-term cancer impact is available for AYAs, since most studies focused on children and adolescents. We aimed to assess various long-term outcomes on AYA survivors of hematological cancers. Methods: We selected patients diagnosed with a first primary hematological cancer between 1997 and 2006, in the Italian nationwide population-based cohort of AYA cancer survivors (i.e. alive at least 5 years after cancer diagnosis). Long-term outcomes of interest were: second malignant neoplasms (SMNs), hospitalizations and overall mortality. We calculated standardized incidence ratios (SIRs), standardized hospitalization rate ratios (SHRs) and standardized mortality rate ratios (SMRs). To study morbidity patterns over time, we modeled observed incidence rates by fitting flexible parametric models for nonlinear patterns and we used linear regression for linear patterns. Results: The study cohort included 5,042 AYA hematological cancer survivors of which 1,237 and 3,805 had a leukaemia and lymphoma diagnosis, respectively. AYA survivors were at substantially increased risk for SMN (SIR=2.1; 95%CI=1.7; 2.6), hospitalisation (SHR=1.5; 95%CI=1.5; 1.6), and mortality (SMR=1.4; 95%CI=1.2; 1.6) with differences between leukaemia and lymphoma survivors. The highest excess risks of hospitalisations were for infectious diseases, respiratory diseases, and diseases of blood and blood-forming organs. The morbidity pattern differs over time by morbidity type. Conclusions: Our results support the need for strict follow-up plans for survivors, and call for further study to better personalised follow-up plans for AYA cancer survivors.
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- 2022
21. Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition
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IRAS OH Epidemiology Chemical Agents, Yammine, S G, Huybrechts, I, Biessy, C, Dossus, L, Panico, S, Sánchez, M J, Benetou, V, Turzanski-Fortner, R, Katzke, V, Idahl, A, Skeie, G, Olsen, K Standahl, Tjønneland, A, Halkjaer, J, Colorado-Yohar, S, Heath, A K, Sonestedt, E, Sartor, H, Schulze, M B, Palli, D, Crous-Bou, M, Dorronsoro, A, Overvad, K, Gurrea, A Barricarte, Severi, G, Vermeulen, R C H, Sandanger, T M, Travis, R C, Key, T, Amiano, P, Van Guelpen, B, Johansson, M, Sund, M, Tumino, R, Wareham, N, Sacerdote, C, Krogh, V, Brennan, P, Riboli, E, Weiderpass, E, Gunter, M J, Chajès, V, IRAS OH Epidemiology Chemical Agents, Yammine, S G, Huybrechts, I, Biessy, C, Dossus, L, Panico, S, Sánchez, M J, Benetou, V, Turzanski-Fortner, R, Katzke, V, Idahl, A, Skeie, G, Olsen, K Standahl, Tjønneland, A, Halkjaer, J, Colorado-Yohar, S, Heath, A K, Sonestedt, E, Sartor, H, Schulze, M B, Palli, D, Crous-Bou, M, Dorronsoro, A, Overvad, K, Gurrea, A Barricarte, Severi, G, Vermeulen, R C H, Sandanger, T M, Travis, R C, Key, T, Amiano, P, Van Guelpen, B, Johansson, M, Sund, M, Tumino, R, Wareham, N, Sacerdote, C, Krogh, V, Brennan, P, Riboli, E, Weiderpass, E, Gunter, M J, and Chajès, V
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- 2023
22. Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC).
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Mahamat-Saleh, Y, Al-Rahmoun, M, Severi, G, Ghiasvand, R, Veierod, MB, Caini, S, Palli, D, Botteri, E, Sacerdote, C, Ricceri, F, Lukic, M, Sánchez, MJ, Pala, V, Tumino, R, Chiodini, P, Amiano, P, Colorado-Yohar, S, Chirlaque, M-D, Ardanaz, E, Bonet, C, Katzke, V, Kaaks, R, Schulze, MB, Overvad, K, Dahm, CC, Antoniussen, CS, Tjønneland, A, Kyrø, C, Bueno-de-Mesquita, B, Manjer, J, Jansson, M, Esberg, A, Mori, N, Ferrari, P, Weiderpass, E, Boutron-Ruault, M-C, Kvaskoff, M, Mahamat-Saleh, Y, Al-Rahmoun, M, Severi, G, Ghiasvand, R, Veierod, MB, Caini, S, Palli, D, Botteri, E, Sacerdote, C, Ricceri, F, Lukic, M, Sánchez, MJ, Pala, V, Tumino, R, Chiodini, P, Amiano, P, Colorado-Yohar, S, Chirlaque, M-D, Ardanaz, E, Bonet, C, Katzke, V, Kaaks, R, Schulze, MB, Overvad, K, Dahm, CC, Antoniussen, CS, Tjønneland, A, Kyrø, C, Bueno-de-Mesquita, B, Manjer, J, Jansson, M, Esberg, A, Mori, N, Ferrari, P, Weiderpass, E, Boutron-Ruault, M-C, and Kvaskoff, M
- Abstract
Experimental evidence suggests that alcohol induces cutaneous carcinogenesis, yet epidemiological studies on the link between alcohol intake and skin cancer have been inconsistent. The European Prospective Investigation into Cancer and Nutrition (EPIC) is a prospective cohort initiated in 1992 in 10 European countries. Alcohol intake at baseline and average lifetime alcohol intake were assessed using validated country-specific dietary and lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated in Cox models. A total of 14 037 skin cancer cases (melanoma: n = 2457; basal-cell carcinoma (BCC): n = 8711; squamous-cell carcinoma (SCC): n = 1928; unknown: n = 941) were identified among 450 112 participants (average follow-up: 15 years). Baseline alcohol intake was positively associated with SCC (>15 vs 0.1-4.9 g/day: HR = 1.44, 95% CI = 1.17-1.77; Ptrend = .001), BCC (HR = 1.12, 95% CI = 1.01-1.23; Ptrend = .04), and melanoma risks in men (HR = 1.17, 95% CI = 0.95-1.44; Ptrend = .17), while associations were more modest in women (SCC: HR = 1.09, 95% CI = 0.90-1.30; Ptrend = .13; BCC: HR = 1.08, 95% CI = 1.00-1.17, Ptrend = .03; melanoma: HR = 0.93, 95% CI = 0.80-1.08, Ptrend = .13). Associations were similar for lifetime alcohol intake, with an attenuated linear trend. Lifetime liquor/spirit intake was positively associated with melanoma (fourth vs first quartile: HR = 1.47, 95% CI = 1.08-1.99; Ptrend = .0009) and BCC risks in men (HR = 1.17, 95% CI = 1.04-1.31; Ptrend = .14). Baseline and lifetime intakes of wine were associated with BCC risk (HR = 1.25 in men; HR = 1.11-1.12; in women). No statistically significant associations were found between beverage types and SCC risk. Intake of beer was not associated with skin cancer risk. Our study suggests positive relationships between alcohol intake and skin cancer risk, which may have important implications for the primary prevention of skin cancer.
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- 2023
23. Evaluation of pre-diagnostic blood protein measurements for predicting survival after lung cancer diagnosis.
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Feng, X, Muller, DC, Zahed, H, Alcala, K, Guida, F, Smith-Byrne, K, Yuan, J-M, Koh, W-P, Wang, R, Milne, RL, Bassett, JK, Langhammer, A, Hveem, K, Stevens, VL, Wang, Y, Johansson, M, Tjønneland, A, Tumino, R, Sheikh, M, Robbins, HA, Feng, X, Muller, DC, Zahed, H, Alcala, K, Guida, F, Smith-Byrne, K, Yuan, J-M, Koh, W-P, Wang, R, Milne, RL, Bassett, JK, Langhammer, A, Hveem, K, Stevens, VL, Wang, Y, Johansson, M, Tjønneland, A, Tumino, R, Sheikh, M, and Robbins, HA
- Abstract
BACKGROUND: To evaluate whether circulating proteins are associated with survival after lung cancer diagnosis, and whether they can improve prediction of prognosis. METHODS: We measured up to 1159 proteins in blood samples from 708 participants in 6 cohorts. Samples were collected within 3 years prior to lung cancer diagnosis. We used Cox proportional hazards models to identify proteins associated with overall mortality after lung cancer diagnosis. To evaluate model performance, we used a round-robin approach in which models were fit in 5 cohorts and evaluated in the 6th cohort. Specifically, we fit a model including 5 proteins and clinical parameters and compared its performance with clinical parameters only. FINDINGS: There were 86 proteins nominally associated with mortality (p < 0.05), but only CDCP1 remained statistically significant after accounting for multiple testing (hazard ratio per standard deviation: 1.19, 95% CI: 1.10-1.30, unadjusted p = 0.00004). The external C-index for the protein-based model was 0.63 (95% CI: 0.61-0.66), compared with 0.62 (95% CI: 0.59-0.64) for the model with clinical parameters only. Inclusion of proteins did not provide a statistically significant improvement in discrimination (C-index difference: 0.015, 95% CI: -0.003 to 0.035). INTERPRETATION: Blood proteins measured within 3 years prior to lung cancer diagnosis were not strongly associated with lung cancer survival, nor did they importantly improve prediction of prognosis beyond clinical information. FUNDING: No explicit funding for this study. Authors and data collection supported by the US National Cancer Institute (U19CA203654), INCA (France, 2019-1-TABAC-01), Cancer Research Foundation of Northern Sweden (AMP19-962), and Swedish Department of Health Ministry.
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- 2023
24. Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma: a case–control study and epidemiological remarks
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Marinaccio, A., Consonni, D., Mensi, C., Mirabelli, D., Migliore, E., Magnani, C., Di Marzio, D., Gennaro, V., Mazzoleni, G., Girardi, P., Negro, C., Romanelli, A., Chellini, E., Grappasonni, I., Madeo, G., Romeo, E., Ascoli, V., Carrozza, F., Angelillo, I. F., Cavone, D., Tumino, R., Melis, M., Curti, S., Brandi, G., Mattioli, S., Iavicoli, S., Dallari, B., Pesatori, A. C., Riboldi, L., Merletti, F., Gangemi, M., Stura, A., Brentisci, C., Gilardetti, M., Benfatto, L., Canessa, P. A., Malacarne, D., Mazzucco, G., Campi, M. G., Fedeli, U., Bressan, V., Gioffre, F., Ballarin, M. N., Chermaz, C., D'Agostin, F., De Michieli, P., Mangone, L., Storchi, C., Sala, O., Badiali, A. M., Cacciarini, V., Giovannetti, L., Martini, A., Calisti, R., Pascucci, C., Stracci, F., Masanotti, G., Davoli, M., Cavariani, F., Ancona, L., Annunziata, A., Menegozzo, S., Napolitano, F., Pelullo, C. P., Vimercati, L., Cascone, G., Frasca, G., Giurdanella, M. C., Martorana, C., Nicita, C., Rollo, C. P., Spata, E., Dardanoni, G., Scondotto, S., Nieddu, V., Pergola, M., Stecchi, S., Marinaccio, A., Consonni, D., Mensi, C., Mirabelli, D., Migliore, E., Magnani, C., Di Marzio, D., Gennaro, V., Mazzoleni, G., Girardi, P., Negro, C., Romanelli, A., Chellini, E., Grappasonni, I., Madeo, G., Romeo, E., Ascoli, V., Carrozza, F., Angelillo, I. F., Cavone, D., Tumino, R., Melis, M., Curti, S., Brandi, G., Mattioli, S., Iavicoli, S., Dallari, B., Pesatori, A. C., Riboldi, L., Merletti, F., Gangemi, M., Stura, A., Brentisci, C., Gilardetti, M., Benfatto, L., Canessa, P. A., Malacarne, D., Mazzucco, G., Campi, M. G., Fedeli, U., Bressan, V., Gioffre, F., Ballarin, M. N., Chermaz, C., D'Agostin, F., De Michieli, P., Mangone, L., Storchi, C., Sala, O., Badiali, A. M., Cacciarini, V., Giovannetti, L., Martini, A., Calisti, R., Pascucci, C., Stracci, F., Masanotti, G., Davoli, M., Cavariani, F., Ancona, L., Annunziata, A., Menegozzo, S., Napolitano, F., Pelullo, C. P., Vimercati, L., Cascone, G., Frasca, G., Giurdanella, M. C., Martorana, C., Nicita, C., Rollo, C. P., Spata, E., Dardanoni, G., Scondotto, S., Nieddu, V., Pergola, M., Stecchi, S., Marinaccio A., Consonni D., Mensi C., Mirabelli D., Migliore E., Magnani C., Di Marzio D., Gennaro V., Mazzoleni G., Girardi P., Negro C., Romanelli A., Chellini E., Grappasonni I., Madeo G., Romeo E., Ascoli V., Carrozza F., Angelillo I.F., Cavone D., Tumino R., Melis M., Curti S., Brandi G., Mattioli S., Iavicoli S., Dallari B., Pesatori A.C., Riboldi L., Merletti F., Gangemi M., Stura A., Brentisci C., Gilardetti M., Benfatto L., Canessa P.A., Malacarne D., Mazzucco G., Campi M.G., Fedeli U., Bressan V., Gioffre F., Ballarin M.N., Chermaz C., D'agostin F., De Michieli P., Mangone L., Storchi C., Sala O., Badiali A.M., Cacciarini V., Giovannetti L., Martini A., Calisti R., Pascucci C., Stracci F., Masanotti G., Davoli M., Cavariani F., Ancona L., Annunziata A., Menegozzo S., Napolitano F., Pelullo C.P., Vimercati L., Cascone G., Frasca G., Giurdanella M.C., Martorana C., Nicita C., Rollo C.P., Spata E., Dardanoni G., Scondotto S., Nieddu V., Pergola M., Stecchi S., Marinaccio, Alessandro, Consonni, Dario, Mensi, Carolina, Mirabelli, Dario, Migliore, Enrica, Magnani, Corrado, Di Marzio, Davide, Gennaro, Valerio, Mazzoleni, Guido, Girardi, Paolo, Negro, Corrado, Romanelli, Antonio, Chellini, Elisabetta, Grappasonni, Iolanda, Madeo, Gabriella, Romeo, Elisa, Ascoli, Valeria, Carrozza, Francesco, Angelillo, Italo Francesco, Cavone, Domenica, Tumino, Rosario, Melis, Massimo, Curti, Stefania, Brandi, Giovanni, Mattioli, Stefano, and Iavicoli, Sergio
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medicine.medical_specialty ,pericardial and tunica vaginalis testis ,Epidemiology ,Population ,rare disease ,national registry ,medicine.disease_cause ,Epidemiology, Italy, National registry, Rare disease ,Asbestos ,epidemiology, Italy, national registry, rare disease ,NO ,03 medical and health sciences ,0302 clinical medicine ,italy ,medicine ,epidemiology ,Italy ,Mesothelioma ,education ,Gynecology ,education.field_of_study ,business.industry ,Public Health, Environmental and Occupational Health ,Tunica vaginalis testis ,Case-control study ,case–control study ,Odds ratio ,medicine.disease ,asbestos ,030210 environmental & occupational health ,National registry ,exposure ,mesothelioma ,malignant mesothelioma ,Original Article ,Public aspects of medicine ,RA1-1270 ,business ,Rare disease - Abstract
Objectives: The purposes of this study are to describe the epidemiology of pericardial and tunica vaginalis testis mesothelioma and assess the role of asbestos exposure for these rare diseases. Methods: Based on incident pericardial and tunica vaginalis testis mesothelioma cases collected from the Italian national mesothelioma registry (ReNaM) in the period 1993–2015, incidence rates, survival median period and prognostic factors have been evaluated. A case–control study has been performed to analyze the association with asbestos exposure (occupational and non-occupational) for these diseases. Results: Between 1993 and 2015, 58 pericardial (20 women and 38 men) and 80 tunica vaginalis testis mesothelioma cases have been registered with a mean annual standardized (world standard population as reference) incidence rates of 0.049 (per million) in men and 0.023 in women for the pericardial site, and 0.095 for tunica vaginalis testis mesothelioma. Occupational exposure to asbestos was significantly associated with the risk of the diseases [odds ratio (OR) 3.68, 95% confidence interval (CI) 1.85–7.31 and OR 3.42, 95% CI 1.93–6.04 in pericardial and tunica vaginalis testis mesothelioma, respectively]. The median survival was 2.5 months for pericardial and 33.0 months for tunica vaginalis testis mesotheliomas. Age was the main predictive factor for survival for both anatomical sites. Conclusions: For the first time in an analytical study, asbestos exposure was associated with pericardial and tunica vaginalis testis mesothelioma risk, supporting the causal role of asbestos for all anatomical sites. The extreme rarity of the diseases, the poor survival and the prognostic role of age have been confirmed based on population and nationwide mesothelioma registry data.
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- 2020
25. Cigarette Smoking and Endometrial Cancer Risk:Observational and Mendelian Randomization Analyses
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Dimou, N, Omiyale, W, Biessy, C, Viallon, V, Kaaks, R, O'Mara, TA, Aglago, EK, Ardanaz, E, Bergmann, MM, Bondonno, NP, Braaten, T, Colorado-Yohar, SM, Crous-Bou, M, Dahm, CC, Fortner, RT, Gram, IT, Harlid, S, Heath, AK, Idahl, A, Kvaskoff, M, Nøst, TH, Overvad, K, Palli, D, Perez-Cornago, A, Sacerdote, C, Sánchez, M-J, Schulze, MB, Severi, G, Simeon, V, Tagliabue, G, Tjønneland, A, Truong, T, Tumino, R, Johansson, M, Weiderpass, E, Murphy, N, Gunter, MJ, Lacey, B, Allen, NE, Dossus, L, Dimou, N., Omiyale, W., Biessy, C., Viallon, V., Kaaks, R., O'Mara, T. A., Aglago, E. K., Ardanaz, E., Bergmann, M. M., Bondonno, N. P., Braaten, T., Colorado-Yohar, S. M., Crous-Bou, M., Dahm, C. C., Fortner, R. T., Gram, I. T., Harlid, S., Heath, A. K., Idahl, A., Kvaskoff, M., Nost, T. H., Overvad, K., Palli, D., Perez-Cornago, A., Sacerdote, C., Sanchez, M. -J., Schulze, M. B., Severi, G., Simeon, V., Tagliabue, G., Tjonneland, A., Truong, T., Tumino, R., Johansson, M., Weiderpass, E., Murphy, N., Gunter, M. J., Lacey, B., Allen, N. E., and Dossus, L.
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Epidemiology ,ESTROGENS ,Polymorphism, Single Nucleotide ,BREAST ,Article ,Cigarette Smoking ,Risk Factors ,GENETIC-VARIANTS ,REGRESSION ,Humans ,Genetic Predisposition to Disease ,Prospective Studies ,11 Medical and Health Sciences ,INDEX ,Cancer och onkologi ,IDENTIFICATION ,WOMEN ,Public Health, Global Health, Social Medicine and Epidemiology ,Mendelian Randomization Analysis ,Endometrial Neoplasms ,OVERLAP ,Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ,Oncology ,Cancer and Oncology ,OBESITY ,Female ,SEX-HORMONES ,Genome-Wide Association Study - Abstract
Background: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses. Methods: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In twosampleMR analyses, genetic variants robustly associated with lifetime amount of smoking (n ¼ 126 variants) and ever having smoked regularly (n ¼ 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined. Results: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91–1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer. Conclusions: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer. Impact: The results from this analysis indicate that smoking is unlikely to be causally linked with endometrial cancer risk., World Health Organization, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, NIHR Imperial Biomedical Research Centre (BRC), Danish Cancer Society, Ligue Contre le Cancer (France) Institut Gustave Roussy (France) MutuelleGenerale de l'Education Nationale (France), Institut National de la Sante et de la Recherche Medicale (Inserm), Deutsche Krebshilfe German Cancer Research Center (DKFZ) (Germany) German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) (Germany) Federal Ministry of Education & Research (BMBF), Fondazione AIRC per la ricerca sul cancro Compagnia di San Paolo Consiglio Nazionale delle Ricerche (CNR), Netherlands Government Netherlands Government, World Cancer Research Fund International (WCRF), Netherlands Government, Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII) (Spain), Junta de Andalucia, Principality of Asturias Regional Government of Basque Country (Spain) Regional Government of Murcia (Spain) Regional Government of Navarra (Spain) Catalan Institute of Oncology - ICO (Spain), Swedish Cancer Society Swedish Research Council County Council of Skane (Sweden) County Council of Vasterbotten (Sweden), Cancer Research UK 14136 C8221/A29017, UK Research & Innovation (UKRI), Medical Research Council UK (MRC) 1000143 MR/M012190/1 MR/N003284/1 MC-UU_12015/1 MC_UU_00006/ 1, Cancer Research UK C864/A14136 C18281/A29019
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- 2022
26. Coffee consumption and risk of non-Hodgkin’s lymphoma: evidence from the Italian multicentre case–control study
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Parodi, Stefano, Merlo, Franco Domenico, Stagnaro, Emanuele, Crosignani, P., Fontana, A., Miligi, L., Masala, G., Nanni, O., Ramazzotti, V., Rodella, S., Costantini, A. Seniori, Tumino, R., Viganò, C., Vindigni, C., Vineis, P., and On behalf of the Working Group for the Epidemiology of Hematolymphopoietic Malignancies in Italy
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- 2017
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27. Eating at restaurants, at work or at home. Is there a difference? A study among adults of 11 European countries in the context of the HECTOR* project
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Orfanos, P, Naska, A, Rodrigues, S, Lopes, C, Freisling, H, Rohrmann, S, Sieri, S, Elmadfa, I, Lachat, C, Gedrich, K, Boeing, H, Katzke, V, Turrini, A, Tumino, R, Ricceri, F, Mattiello, A, Palli, D, Ocké, M, Engeset, D, Oltarzewski, M, Nilsson, L M, Key, T, and Trichopoulou, A
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- 2017
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28. Plasma methionine, choline, betaine, and dimethylglycine in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Nitter, M., Norgård, B., de Vogel, S., Eussen, S.J.P.M., Meyer, K., Ulvik, A., Ueland, P.M., Nygård, O., Vollset, S.E., Bjørge, T., Tjønneland, A., Hansen, L., Boutron-Ruault, M., Racine, A., Cottet, V., Kaaks, R., Kühn, T., Trichopoulou, A., Bamia, C., Naska, A., Grioni, S., Palli, D., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H.B., van Kranen, H., Peeters, P.H., Weiderpass, E., Dorronsoro, M., Jakszyn, P., Sánchez, M., Argüelles, M., Huerta, J.M., Barricarte, A., Johansson, M., Ljuslinder, I., Khaw, K., Wareham, N., Freisling, H., Duarte-Salles, T., Stepien, M., Gunter, M.J., and Riboli, E.
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- 2014
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29. Circulating prolactin and breast cancer risk among pre- and postmenopausal women in the EPIC cohort
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Tikk, K., Sookthai, D., Johnson, T., Rinaldi, S., Romieu, I., Tjønneland, A., Olsen, A., Overvad, K., Clavel-Chapelon, F., Baglietto, L., Boeing, H., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Pala, V., Tumino, R., Rosso, S., Panico, S., Agudo, A., Menéndez, V., Sánchez, M.-J., Amiano, P., Huerta Castaño, J.M., Ardanaz, E., Bueno-de-Mesquita, H.B., Monninkhof, E., Onland-Moret, C., Andersson, A., Sund, M., Weiderpass, E., Khaw, K.-T., Key, T.J., Travis, R.C., Gunter, M.J., Riboli, E., Dossus, L., and Kaaks, R.
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- 2014
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30. Management of rectal cancers in relation to treatment guidelines: a population-based study comparing Italian and French patients
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Velten, M., Launoy, G., Bouvier, V., Faivre, J., Bouvier, A.M., Woronoff, A.S., Robaszkiewicz, M., Buémi, A., Trétarre, B., Colonna, M., Delafosse, P., Molinié, F., Bara, S., Grosclaude, P., Sant, M., Minicozzi, P., Allemani, C., Kaleci, S., Maffei, S., de Leon, M. Ponz, Giacomin, A., Crocetti, E., Caldarella, A., Federico, M., Iachetta, F., Fusco, M., Tumino, R., Mangone, L., Vicentini, M., Giorgi Rossi, P., Falcini, F., Budroni, M., Cesaraccio, R., Minicozzi, Pamela, Bouvier, Anne-Marie, Faivre, Jean, and Sant, Milena
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- 2014
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31. Prediagnostic transcriptomic markers of Chronic lymphocytic leukemia reveal perturbations 10 years before diagnosis
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Georgiadis, P., Botsivali, M., Papadopoulou, C., Chatziioannou, A., Valavanis, I., Gottschalk, R., van Leeuwen, D., Timmermans, L., Keun, H.C., Athersuch, T.J., Lenner, P., Bendinelli, B., Stephanou, E.G., Myridakis, A., Kogevinas, M., Saberi-Hosnijeh, F., Fazzo, L., de Santis, M., Comba, P., Kiviranta, H., Rantakokko, P., Airaksinen, R., Ruokojarvi, P., Gilthorpe, M.S., Fleming, S., Fleming, T., Tu, Y.-K., Jonsson, B., Lundh, T., Chien, K.-L., Chen, W.J., Lee, W.-C., Hsiao, C.K., Kuo, P.-H., Hung, H., Liao, S.-F., Chadeau-Hyam, M., Vermeulen, R.C.H., Hebels, D.G.A.J., Castagné, R., Campanella, G., Portengen, L., Kelly, R.S., Bergdahl, I.A., Melin, B., Hallmans, G., Palli, D., Krogh, V., Tumino, R., Sacerdote, C., Panico, S., de Kok, T.M.C.M., Smith, M.T., Kleinjans, J.C.S., Vineis, P., and Kyrtopoulos, S.A.
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- 2014
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32. Late Mortality, Subsequent Malignant Neoplasms and Hospitalisations in Long-Term Survivors of Adolescent and Young Adult Hematological Cancers
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Trama, A., Vener, C., Lasalvia, P., Bernasconi, A., Zorzi, M., Andreano, A., Contiero, P., Manneschi, G., Falcini, F., Castaing, M., Filiberti, R. A., Gasparotti, C., Cirilli, C., Amodio, R., Bisceglia, I., Iacovacci, S., Vitale, M. F., Stracci, F., Gentilini, M. A., Tumino, R., Carone, S., Sampietro, G., Melcarne, A., Gatti, L., Boschetti, L., Corti, M., Rognoni, M., Coviello, E., Pesce, M. T., D'Orsi, G., Fanetti, A. C., De Lorenzis, L., Candela, G., Savoia, F., Pascucci, C., Castelli, M., Storchi, C., Trama, A, Vener, C, Lasalvia, P, Bernasconi, A, Zorzi, M, Andreano, A, Contiero, P, Manneschi, G, Falcini, F, Castaing, M, Filiberti, R, Gasparotti, C, Cirilli, C, Amodio, R, Bisceglia, I, Iacovacci, S, Vitale, M, Stracci, F, Gentilini, M, Tumino, R, Carone, S, Sampietro, G, Melcarne, A, Gatti, L, Boschetti, L, Corti, M, Rognoni, M, Coviello, E, Pesce, M, D'Orsi, G, Fanetti, A, De Lorenzis, L, Candela, G, Savoia, F, Pascucci, C, Castelli, M, and Storchi, C
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adolescents and young adults (AYAs) ,long-term outcome ,Cancer Research ,Oncology ,cancer survivor ,hematological cancers ,cancer survivors ,hematological cancer ,population-based cohort ,long-term outcomes - Abstract
BackgroundIncreased success in the treatment of hematological cancers contributed to the increase of 5-year survival for most adolescent and young adults (AYAs) with these tumours. However, as 5-year survival increased, it became clear that AYA long-term survivors were at increased risk for severe late effects. Moreover, limited information on long-term cancer impact is available for AYAs, since most studies focused on children and adolescents. We aimed to assess various long-term outcomes on AYA survivors of hematological cancers.MethodsWe selected patients diagnosed with a first primary hematological cancer between 1997 and 2006, in the Italian nationwide population-based cohort of AYA cancer survivors (i.e. alive at least 5 years after cancer diagnosis). Long-term outcomes of interest were: second malignant neoplasms (SMNs), hospitalizations and overall mortality. We calculated standardized incidence ratios (SIRs), standardized hospitalization rate ratios (SHRs) and standardized mortality rate ratios (SMRs). To study morbidity patterns over time, we modeled observed incidence rates by fitting flexible parametric models for nonlinear patterns and we used linear regression for linear patterns.ResultsThe study cohort included 5,042 AYA hematological cancer survivors of which 1,237 and 3,805 had a leukaemia and lymphoma diagnosis, respectively. AYA survivors were at substantially increased risk for SMN (SIR=2.1; 95%CI=1.7; 2.6), hospitalisation (SHR=1.5; 95%CI=1.5; 1.6), and mortality (SMR=1.4; 95%CI=1.2; 1.6) with differences between leukaemia and lymphoma survivors. The highest excess risks of hospitalisations were for infectious diseases, respiratory diseases, and diseases of blood and blood-forming organs. The morbidity pattern differs over time by morbidity type.ConclusionsOur results support the need for strict follow-up plans for survivors, and call for further study to better personalised follow-up plans for AYA cancer survivors.
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- 2022
33. Fibre intake and the development of inflammatory bowel disease: A European prospective multi-centre cohort study (EPIC-IBD)
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Andersen, Vibeke, Chan, Simon, Luben, Robert, Khaw, Kay-Tee, Olsen, Anja, Tjonneland, Anne, Kaaks, R, Grip, Olof, Bergmann, M M, Boeing, H, Hultdin, Johan, Karling, Pontus, Overvad, Kim, Oldenburg, Bas, Opstelten, Jorrit, Boutron-Ruault, Marie-Christine, Carbonnel, Franck, Racine, Antoine, Key, Timothy, Masala, Giovanna, Palli, Domenico, Tumino, R, Trichopoulou, A, Riboli, Elio, and Hart, Andrew
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- 2018
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34. Physical activity, sex steroid, and growth factor concentrations in pre- and post-menopausal women: a cross-sectional study within the EPIC cohort
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Rinaldi, S., Kaaks, R., Friedenreich, C. M., Key, T. J., Travis, R., Biessy, C., Slimani, N., Overvad, K., Østergaard, J. N., Tjønneland, A., Olsen, A., Mesrine, S., Fournier, A., Dossus, L., Lukanova, A., Johnson, T., Boeing, H., Vigl, M., Trichopoulou, A., Benetou, V., Trichopoulos, D., Masala, G., Krogh, V., Tumino, R., Ricceri, F., Panico, S., Bueno-de-Mesquita, H. B., Monninkhof, E. M., May, A. M., Weiderpass, E., Quirós, J. R., Travier, N., Molina-Montes, E., Amiano, P., Huerta, J. M., Ardanaz, E., Sund, M., Johansson, M., Khaw, K. T., Wareham, N., Scalbert, A., Gunter, M. J., Riboli, E., and Romieu, I.
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- 2014
35. Alcohol consumption and risk of urothelial cell bladder cancer in the European prospective investigation into cancer and nutrition cohort
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Botteri, E., Ferrari, P., Roswall, N., Tjønneland, A., Hjartåker, A., Huerta, J.M., Fortner, R.T., Trichopoulou, A., Karakatsani, A., La Vecchia, C., Pala, V., Perez‐Cornago, A., Sonestedt, E., Liedberg, F., Overvad, K, Sánchez, M.J., Gram, I.T., Stepien, M., Trijsburg, L., Börje, L., Johansson, M., Kühn, T., Panico, S., Tumino, R., Bueno‐de‐Mesquita, H. B(as), and Weiderpass, E.
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- 2017
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36. Patient presentation, skin biopsy utilization and cutaneous malignant melanoma incidence and mortality in northern Italy: Trends and correlations
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Bucchi, L., Mancini, S., Zamagni, F., Crocetti, E., Dal Maso, L., Ferretti, S., Baldacchini, F., Giuliani, O., Ravaioli, A., Vattiato, R., Brustolin, A., Candela, G., Carone, S., Carrozzi, G., Cavallo, R., Dinaro, Y. M., Ferrante, M., Iacovacci, S., Mazzoleni, G., Musolino, A., Rizzello, R. V., Serraino, D., Biggeri, A., Stanganelli, I., Falcini, F., Bella, F., Cirilli, C., Curatella, S., Tumino, R., Galluzzo, C., Stracci, F., Gili, A., Ippolito, A., Michiara, M., Oriente, C., Piffer, S., Scuderi, T., Toffolutti, F., and Vittadello, F.
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Infectious Diseases ,Dermatology - Abstract
The global increase in incidence of cutaneous malignant melanoma (CMM) occurring in the past decades has been partly attributed to increased diagnostic scrutiny of early lesions, with a potential phenomenon of overdiagnosis. The reported positive linear relation between skin biopsy rate and incidence of early CMM is compatible with this hypothesis.We explored the ecological association between the trends in annual dermatologic office visit rates, skin biopsy rates, incidence rates of in situ and invasive CMM by tumour thickness category, and CMM mortality rates in the Emilia-Romagna Region (northern Italy).Four cancer registries covering a population of 2,696,000 provided CMM incidence data for the years 2003-2017. Dermatologic office visit rates and skin biopsy rates were calculated using the Regional outpatient care database. All rates were age-standardized. Trends were described with the estimated average annual per cent change (EAAPC). Correlations were tested with the Spearman correlation coefficient.Incidence increased significantly. The increase was steeper for in situ CMM (EAAPC: men, 10.2; women, 6.9) followed by CMM0.8 mm thick (9.1; 5.2), but the rates grew significantly for most subgroups of CMMs ≥0.8 mm thick. Mortality decreased significantly among women (-2.3) and non-significantly among men. For dermatologic office visit rate and skin biopsy rate the EAAPC were, respectively, 1.7 and 1.8 for men and 1.2 and 0.9 for women. Annual dermatologic office visit rate correlated with skin biopsy rate in both sexes. However, the proportion of skin biopsies out of dermatologic office visits was constant across the years (range: men, 0.182-0.216; women, 0.157-0.191).In Italy, the increasing CMM incidence trend is, at least in part, genuine. Overdiagnosis-if any-is due to an increased patient presentation at dermatologic offices and not to a lower dermatologic threshold to perform biopsy.
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- 2022
37. Authors’ response: Mezei et al's 'comments on a recent case-control study of malignant mesothelioma of the pericardium and the tunica vaginalis testis'
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Marinaccio A., Consonni D., Mensi C., Mirabelli D., Migliore E., Magnani C., Di Marzio D., Gennaro V., Mazzoleni G., Girardi P., Negro C., Romanelli A., Chellini E., Grappasonni I., Madeo G., Romeo E., Ascoli V., Carrozza F., Angelillo I. F., Cavone D., Tumino R., Melis M., Curti S., Brandi G., Mattioli S., Iavicoli S., Marinaccio, A., Consonni, D., Mensi, C., Mirabelli, D., Migliore, E., Magnani, C., Di Marzio, D., Gennaro, V., Mazzoleni, G., Girardi, P., Negro, C., Romanelli, A., Chellini, E., Grappasonni, I., Madeo, G., Romeo, E., Ascoli, V., Carrozza, F., Angelillo, I. F., Cavone, D., Tumino, R., Melis, M., Curti, S., Brandi, G., Mattioli, S., Iavicoli, S., Marinaccio A., Consonni D., Mensi C., Mirabelli D., Migliore E., Magnani C., Di Marzio D., Gennaro V., Mazzoleni G., Girardi P., Negro C., Romanelli A., Chellini E., Grappasonni I., Madeo G., Romeo E., Ascoli V., Carrozza F., Angelillo I.F., Cavone D., Tumino R., Melis M., Curti S., Brandi G., Mattioli S., and Iavicoli S.
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Mesothelioma ,Tunica vaginalis testis ,Economica ,Letter ,pericardial and tunica vaginalis testis (TVT) ,Socio-culturale ,Ambientale ,mesothelioma ,ReNaM ,Key terms: asbestos ,Key terms: asbesto ,Pericardium ,Malignant mesothelioma - Abstract
Mezei et al's letter (1) is an opportunity to provide more details about our study on pericardial and tunica vaginalis testis (TVT) mesothelioma (2), which is based on the Italian national mesothelioma registry (ReNaM): a surveillance system on mesothelioma, with individual asbestos exposure assessment. Incidence of pericardial mesothelioma has been estimated around 0.5 and 0.2 cases per 10 million person-years in men and women, respectively, and around 1 case for TVT mesothelioma. ReNaM collected 138 cases thanks to its long period of observation (1993-2015) and national coverage. Conducting a population-based case-control study with incidence-density sampling of controls across Italy and over a 23 year time-span should have been planned in 1993 and would have been beyond feasibility and ReNaM scope. We rather exploited two existing series of controls (3). The resulting incomplete time- and spatial matching of cases and controls is a limitation of our study and has been acknowledged in our article. The analysis of case-control studies can nevertheless be accomplished in logistic models accounting for the variables of interest, in both individually and frequency matched studies (4). Furthermore, analyses restricted to (i) regions with enrolled controls, (ii) cases with definite diagnosis, (iii) incidence period 2000-2015, and (iv) subjects born before 1950 have been provided in the manuscript, confirming the strength of the association with asbestos exposure (supplemental material tables S4-7). Following Mezei et al's suggestion, we performed further sensitivity analyses by restriction to regions with controls and fitting conditional regression models using risk-sets made of combinations of age and year of birth categories (5-year classes for both). We confirmed positive associations with occupational exposure to asbestos of pericardial mesothelioma, with odds ratios (OR) (adjusted for region) of 9.16 among women [95% confidence interval (CI) 0.56-150] and 5.63 (95% CI 1.02-31.0) among men; for TVT mesothelioma the OR was 7.70 (95% CI 2.89-20.5). Using risk sets of age categories and introducing year of birth (5-year categories) as a covariate (dummy variables) the OR were similar: OR (adjusted for region) of 9.17 among women (95% CI 0.56-150) and 5.76 (95% CI 1.07-31.0) among men; for TVT the OR was 9.86 (95% CI 3.46-28.1). Possible bias from incomplete geographical overlap between cases and controls has been addressed in the paper (table S4) and above. In spatially restricted analyses, OR were larger than in those including cases from the whole country, indicating that bias was towards the null. Mezei et al further noted that "the regional distribution of controls is different from that of person-time observed". This objection is not relevant because the above analyses were adjusted by region. Our controls were provided by a population-based study on pleural mesothelioma (called MISEM) and a hospital-based study on cholangiocarcinoma (called CARA). In MISEM, the response rate was 48.4%, a low but not unexpected rate as participation among population controls is usually lower and has been declining over time (5). It is important to underline that ReNaM applied the same questionnaire that was used for interviews and carried out the same exposure assessment as both MISEM and CARA. As repeatedly stated in ReNaM papers (6-7), each regional operating center assesses asbestos exposure based on the individual questionnaire, other available information, and knowledge of local industries. Occupational exposure to asbestos is classified as definite, probable or possible. Occupational exposure is (i) definite when the subject`s work was reported or otherwise known to have involved the use of asbestos or asbestos-containing materials (MCA); (ii) probable when subjects worked in factories where asbestos or MCA were used, but their personal exposure could not be documented; and (iii) possible when they were employed in industrial activities known to entail the use of asbestos or MCA. Hence, the definite and probable categories are closer to one another and were combined in our analyses. In any case, restricting analyses to subjects with definite occupational exposure and using each set of controls separately, as suggested by Mezei et al, yielded elevated OR for TVT and pericardial mesothelioma among men using both the above described modelling strategies; the OR could not be calculated for women. There were 70 (25 pericardial and 45 TVT) occupationally exposed mesothelioma cases. In population-based studies, analyses by occupation are limited by the low prevalence of most specific jobs. As briefly reported in our paper, for purely descriptive purposes, the industrial activity of exposure (cases may have multiple exposures), were construction (22 exposures, 7 and 15 for pericardial and TVT mesotheliomas, respectively), steel mills and other metal working industries (4 and 11), textile industries (2 and 3), and agriculture (2 and 5); other sectors had lower exposure frequencies. The absence of industries like asbestos-cement production, shipbuilding and railway carriages production/repair should not be surprising and had already been observed (7). In the Italian multicenter cohort study of asbestos workers (8), given the person-years of observation accrued by workers employed in these industries and gender- and site-specific crude incidence rates, approximately 0.1 case of pericardial and 0.2 of TVT mesothelioma would have been expected from 1970 to 2010. Even increasing ten-fold such figures to account for higher occupational risks among these workers would not change much. Asbestos exposure in agriculture has been repeatedly discussed in ReNaM reports (9: pages 70, 73, 128, 164 and 205). Exposure opportunities included the presence of asbestos in wine production, reuse of hessian bags previously containing asbestos, or construction and maintenance of rural buildings. Similarly, mesothelioma cases and agricultural workers exposed to asbestos have been noted in France (10). In conclusion, the additional analyses we performed according to Mezei et al's suggestions confirm the association between asbestos exposure and pericardial and TVT mesothelioma, supporting the causal role of asbestos for all mesotheliomas. ReNaM`s continuing surveillance system with national coverage is a precious platform for launching analytical studies on pleural and extra pleural mesothelioma. References 1. Mezei G, Chang ET, Mowat FS, Moolgavkar SH. Comments on a recent case-control study of malignant mesothelioma of the pericardium and the tunica vaginalis testis Scand J Work Environ Health. 2021;47(1):85-86. https://doi.org/10.5271/3909 2. Marinaccio A, Consonni D, Mensi C, Mirabelli D, Migliore E, Magnani C et al.; ReNaM Working Group. Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma: a case-control study and epidemiological remarks. Scand J Work Environ Health. 2020;46(6):609-617. https://doi.org/10.5271/sjweh.3895. 3. Greenland S. Control-initiated case-control studies. Int J Epidemiol 1985 Mar;14(1):130-4. https://doi.org/10.1093/ije/14.1.130. 4. Pearce N. Analysis of matched case-control studies. BMJ 2016 Feb;352:i969. https://doi.org/10.1136/bmj.i969. 5. Bigert C, Gustavsson P, Straif K, Pesch B, Brüning T, Kendzia B et al. Lung cancer risk among cooks when accounting for tobacco smoking: a pooled analysis of case-control studies from Europe, Canada, New Zealand, and China. J Occup Environ Med 2015 Feb;57(2):202-9. https://doi.org/10.1097/JOM.0000000000000337. 6. Marinaccio A, Binazzi A, Marzio DD, Scarselli A, Verardo M, Mirabelli D et al.; ReNaM Working Group. Pleural malignant mesothelioma epidemic: incidence, modalities of asbestos exposure and occupations involved from the Italian National Register. Int J Cancer 2012 May;130(9):2146-54. https://doi.org/10.1002/ijc.26229. 7. Marinaccio A, Binazzi A, Di Marzio D, Scarselli A, Verardo M, Mirabelli D et al. Incidence of extrapleural malignant mesothelioma and asbestos exposure, from the Italian national register. Occup Environ Med 2010 Nov;67(11):760-5. https://doi.org/10.1136/oem.2009.051466. 8. Ferrante D, Chellini E, Merler E, Pavone V, Silvestri S, Miligi L et al.; the working group. Italian pool of asbestos workers cohorts: mortality trends of asbestos-related neoplasms after long time since first exposure. Occup Environ Med 2017 Dec;74(12):887-98. https://doi.org/10.1136/oemed-2016-104100. 9. ReNaM VI Report. Available from: https://www.inail.it/cs/internet/docs/alg-pubbl-registro-nazionale-mesoteliomi-6-rapporto.pdf. Italian 10. Marant Micallef C, Shield KD, Vignat J, Baldi I, Charbotel B, Fervers B et al. Cancers in France in 2015 attributable to occupational exposures. Int J Hyg Environ Health 2019 Jan;222(1):22-9. https://doi.org/10.1016/j.ijheh.2018.07.015.
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- 2021
38. SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe
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Hageman, S., Pennells, L., Ojeda, F., Kaptoge, S., Kuulasmaa, K., Vries, T. de, Xu, Z., Kee, F., Chung, R., Wood, A., McEvoy, J.W., Veronesi, G., Bolton, T., Dendale, P., Ference, B.A., Halle, M., Timmis, A., Vardas, P., Danesh, J., Graham, I., Salomaa, V., Visseren, F., Bacquer, D. de, Blankenberg, S., Dorresteijn, J., Angelantonio, E. di, Achenbach, S., Aleksandrova, K., Amiano, P., Amouyel, P., Andersson, J., Bakker, S.J.L., Costa, R.B.D., Beulens, J.W.J., Blaha, M., Bobak, M., Boer, J.M.A., Bonet, C., Bonnet, F., Boutron-Ruault, M.C., Braaten, T., Brenner, H., Brunner, F., Brunner, E.J., Brunstrom, M., Buring, J., Butterworth, A.S., Capkova, N., Cesana, G., Chrysohoou, C., Colorado-Yohar, S., Cook, N.R., Cooper, C., Dahm, C.C., Davidson, K., Dennison, E., Castelnuovo, A. di, Donfrancesco, C., Dorr, M., Dorynska, A., Eliasson, M., Engstrom, G., Ferrari, P., Ferrario, M., Ford, I., Fu, M., Gansevoort, R.T., Giampaoli, S., Gillum, R.F., Camara, A.G. de la, Grassi, G., Hansson, P.O., Huculeci, R., Hveem, K., Iacoviello, L., Ikram, M.K., Jorgensen, T., Joseph, B., Jousilahti, P., Jukema, J.W., Kaaks, R., Katzke, V., Kavousi, M., Kiechl, S., Klotsche, J., Konig, W., Kronmal, R.A., Kubinova, R., Kucharska-Newton, A., Lall, K., Lehmann, N., Leistner, D., Linneberg, A., Pablos, D.L., Lorenz, T., Lu, W.T., Luksiene, D., Lyngbakken, M., Magnussen, C., Malyutina, S., Ibanez, A.M., Masala, G., Mathiesen, E.B., Matsushita, K., Meade, T.W., Melander, O., Meyer, H.E., Moons, K.G.M., Moreno-Iribas, C., Muller, D., Munzel, T., Nikitin, Y., Nordestgaard, B.G., Omland, T., Onland, C., Overvad, K., Packard, C., Pajak, A., Palmieri, L., Panagiotakos, D., Panico, S., Perez-Cornago, A., Peters, A., Pietila, A., Pikhart, H., Psaty, B.M., Quarti-Trevano, F., Garcia, J.R.Q., Riboli, E., Ridker, P.M., Rodriguez, B., Rodriguez-Barranco, M., Rosengren, A., Roussel, R., Sacerdote, C., Sans, S., Sattar, N., Schiborn, C., Schmidt, B., Schottker, B., Schulze, M., Schwartz, J.E., Selmer, R.M., Shea, S., Shipley, M.J., Sieri, S., Soderberg, S., Sofat, R., Tamosiunas, A., Thorand, B., Tillmann, T., Tjonneland, A., Tong, T.Y.N., Trichopoulou, A., Tumino, R., Tunstall-Pedoe, H., Tybjaerg-Hansen, A., Tzoulaki, J., Heijden, A. van der, Schouw, Y.T. van der, Verschuren, W.M.M., Volzke, H., Waldeyer, C., Wareham, N.J., Weiderpass, E., Weidinger, F., Wild, P., Willeit, J., Willeit, P., Wilsgaard, T., Woodward, M., Zeller, T., Zhang, D.D., Zhou, B., SCORE2 Working Grp, ESC Cardiovasc Risk Collaboration, collaboration, SCORE2 working group and ESC Cardiovascular risk, Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), Epidemiology, Neurology, Achenbach, S, Aleksandrova, K, Amiano, P, San Sebastian, D, Amouyel, P, Andersson, J, Bakker, S, Da Providencia Costa, R, Beulens, J, Blaha, M, Bobak, M, Boer, J, Bonet, C, Bonnet, F, Boutron-Ruault, M, Braaten, T, Brenner, H, Brunner, F, Brunner, E, Brunström, M, Buring, J, Butterworth, A, Capkova, N, Cesana, G, Chrysohoou, C, Colorado-Yohar, S, Cook, N, Cooper, C, Dahm, C, Davidson, K, Dennison, E, Di Castelnuovo, A, Donfrancesco, C, Dörr, M, Doryńska, A, Eliasson, M, Engström, G, Ferrari, P, Ferrario, M, Ford, I, Fu, M, Gansevoort, R, Giampaoli, S, Gillum, R, Gómez de la Cámara, A, Grassi, G, Hansson, P, Huculeci, R, Hveem, K, Iacoviello, L, Ikram, M, Jørgensen, T, Joseph, B, Jousilahti, P, Wouter Jukema, J, Kaaks, R, Katzke, V, Kavousi, M, Kiechl, S, Klotsche, J, König, W, Kronmal, R, Kubinova, R, Kucharska-Newton, A, Läll, K, Lehmann, N, Leistner, D, Linneberg, A, Pablos, D, Lorenz, T, Lu, W, Luksiene, D, Lyngbakken, M, Magnussen, C, Malyutina, S, Ibañez, A, Masala, G, Mathiesen, E, Matsushita, K, Meade, T, Melander, O, Meyer, H, Moons, K, Moreno-Iribas, C, Muller, D, Münzel, T, Nikitin, Y, Nordestgaard, B, Omland, T, Onland, C, Overvad, K, Packard, C, Pająk, A, Palmieri, L, Panagiotakos, D, Panico, S, Perez-Cornago, A, Peters, A, Pietilä, A, Pikhart, H, Psaty, B, Quarti-Trevano, F, Garcia, J, Riboli, E, Ridker, P, Rodriguez, B, Rodriguez-Barranco, M, Rosengren, A, Roussel, R, Sacerdote, C, S, S, Sattar, N, Schiborn, C, Schmidt, B, Schöttker, B, Schulze, M, Schwartz, J, Selmer, R, Shea, S, Shipley, M, Sieri, S, Söderberg, S, Sofat, R, Tamosiunas, A, Thorand, B, Tillmann, T, Tjønneland, A, Tong, T, Trichopoulou, A, Tumino, R, Tunstall-Pedoe, H, Tybjaerg-Hansen, A, Tzoulaki, J, van der Heijden, A, van der Schouw, Y, Verschuren, W, Völzke, H, Waldeyer, C, Wareham, N, Weiderpass, E, Weidinger, F, Wild, P, Willeit, J, Willeit, P, Wilsgaard, T, Woodward, M, Zeller, T, Zhang, D, Zhou, B, and Apollo - University of Cambridge Repository
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Male ,Cardiology ,RATIONALE ,Blood Pressure ,Disease ,030204 cardiovascular system & hematology ,PROFILE ,ACUTE CORONARY EVENTS ,VALIDATION ,Europe/epidemiology ,03 medical and health sciences ,0302 clinical medicine ,SDG 3 - Good Health and Well-being ,DESIGN ,Clinical Research ,Risk Factors ,Diabetes mellitus ,medicine ,PARTICIPANTS ,Humans ,030212 general & internal medicine ,Risk factor ,Aged ,Primary prevention ,business.industry ,10-year CVD risk ,Incidence (epidemiology) ,Cardiovascular Diseases/epidemiology ,Risk Prediction ,Cardiovascular Disease ,Primary Prevention ,10-year Cvd Risk ,External validation ,PRIMARY-CARE ,Middle Aged ,medicine.disease ,Cardiovascular disease ,Risk prediction ,3. Good health ,Europe ,Prediction algorithms ,Blood pressure ,Cardiovascular Diseases ,Smoking status ,Female ,Cardiology and Cardiovascular Medicine ,business ,Algorithms ,Demography - Abstract
Aims The aim of this study was to develop, validate, and illustrate an updated prediction model (SCORE2) to estimate 10-year fatal and non-fatal cardiovascular disease (CVD) risk in individuals without previous CVD or diabetes aged 40-69 years in Europe.Methods and results We derived risk prediction models using individual-participant data from 45 cohorts in 13 countries (677 684 individuals, 30 121 CVD events). We used sex-specific and competing risk-adjusted models, including age, smoking status, systolic blood pressure, and total- and HDL-cholesterol. We defined four risk regions in Europe according to country-specific CVD mortality, recalibrating models to each region using expected incidences and risk factor distributions. Region-specific incidence was estimated using CVD mortality and incidence data on 10 776 466 individuals. For external validation, we analysed data from 25 additional cohorts in 15 European countries (1 133 181 individuals, 43 492 CVD events). After applying the derived risk prediction models to external validation cohorts, C-indices ranged from 0.67 (0.65-0.68) to 0.81 (0.76-0.86). Predicted CVD risk varied several-fold across European regions. For example, the estimated 10-year CVD risk for a 50-year-old smoker, with a systolic blood pressure of 140 mmHg, total cholesterol of 5.5 mmol/L, and HDL-cholesterol of 1.3 mmol/L, ranged from 5.9% for men in low- risk countries to 14.0% for men in very high-risk countries, and from 4.2% for women in low-risk countries to 13.7% for women in very high-risk countries.Conclusion SCORE2-a new algorithm derived, calibrated, and validated to predict 10-year risk of first-onset CVD in European populations-enhances the identification of individuals at higher risk of developing CVD across Europe. Acknowledgements We thank investigators and participants of the several studies that contributed data to the Emerging Risk Factors Collaboration (ERFC). This research has been conducted using the UK Biobank Resource under Application Number 26865. Data from the Clinical Practice Research Datalink (CPRD) were obtained under licence from the UK Medicines and Healthcare products Regulatory Agency (protocol 162RMn2). CPRD uses data provided by patients and collected by the NHS as part of their care and support. We thank all EPIC participants and staff for their contribution to the study, the laboratory teams at the Medical Research Council Epidemiology Unit for sample management and Cambridge Genomic Services for genotyping, Sarah Spackman for data management and the team at the EPIC-CVD Coordinating Centre for study co-ordination and administration. Funding The ERFC co-ordinating centre was underpinned by programme grants from the British Heart Foundation (SP/09/002; RG/13/13/30194; RG/18/13/33946), BHF Centre of Research Excellence (RE/18/1/34212), the UK Medical Research Council (MR/L003120/1), and the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (BRC1215-20014), with project-specific support received from the UK NIHR [*], British United Provident Association UK Foundation and an unrestricted educational grant from GlaxoSmithKline. A variety of funding sources have supported recruitment, follow-up, and laboratory measurements in the studies contributing data to the ERFC, which are listed on the ERFC website (www.phpc.cam.ac.uk/ceu/erfc/list-of-studies). *The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. This work was supported by Health Data Research UK, which is funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation, and Wellcome. The MORGAM Project has received funding from EU projects MORGAM (Biomed BMH4-CT98-3183), GenomEUtwin (FP5, QLG2-CT-2002-01254), ENGAGE (FP7, HEALTH-F4-2007-201413),CHANCES (FP7, HEALTH-F3-2010-242244), BiomarCaRE (FP7,HEALTH-F2-2011-278913), euCanSHare (Horizon 2020, No. 825903) and AFFECT-EU (Horizon 2020, No. 847770); and Medical Research Council, London (G0601463, No. 80983: Biomarkers in the MORGAM Populations). This has supported central coordination, workshops and part of the activities of the MORGAM Data Centre, the MORGAM Laboratories and the MORGAM Participating Centres EPIC-CVD was funded by the European Research Council (268834), and the European Commission Framework Programme 7 (HEALTH-F2-2012-279233). This work was supported by the Estonian Research Council grant PUTs (PRG687, PUT1660, PUT1665, PRG184), by European Union through the European Regional Development Fund project no. MOBERA5 (Norface Network project no 462.16.107), by the Green ICT programme under Norway Grants 2014 – 2021 (grant number EU53928), by the European Union through Horizon 2020 grant no. 810645 and through the European Regional Development Fund (Project No. 2014-2020.4.01.16-0125) and by the PRECISE4Q consortium. PRECISE4Q project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under Grant agreement 777107. This work was partly funded through the CoMorMent project. CoMorMent has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under Grant agreement 847776. The KORA study was initiated and financed by the Helmholtz Zentrum Mu¨nchen—German Research Center for Environmental Health, which is funded by the German Federal Ministry of Education and Research (BMBF) and by the State of Bavaria. The KORA study was supported by a research grant from the Virtual Institute of Diabetes Research (Helmholtz Zentrum Mu¨nchen), the Clinical Cooperation Group Diabetes between Ludwig-Maximilians-Universita¨t Mu¨nchen and Helmholtz Zentrum Mu¨nchen, and by the German Diabetes Center (DDZ). The HAPIEE project, Institute, was supported by grants from the Wellcome Trust (064947/Z/01/Z; WT081081) and US National Institute on Aging (1R01 and AG23522). The co-ordination of EPIC is financially supported by International Agency for Research on Cancer (IARC) and also by the Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, which has additional infrastructure support provided by the NIHR Imperial Biomedical Research Centre (BRC). The national cohorts are supported by: Danish Cancer Society (Denmark); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Ge´ne´rale de l’Education Nationale, Institut National de la Sante´ et de la Recherche Me´dicale (INSERM) (France); German Cancer Aid, German Cancer Research Center (DKFZ), German Institute of Human Nutrition Potsdam Rehbruecke (DIfE), Federal Ministry of Education and Research (BMBF) (Germany); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy, Compagnia di SanPaolo and National Research Council (Italy); Dutch 2448 SCORE2 working group and ESC Cardiovascular Risk Collaboration Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Health Research Fund (FIS)—Instituto de Salud Carlos III (ISCIII), Regional Governments of Andalucı´a, Asturias, Basque Country, Murcia and Navarra, and the Catalan Institute of Oncology—ICO (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Ska˚ne and Va¨sterbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C8221/A29017 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk; MR/M012190/1 to EPIC-Oxford) (United Kingdom)
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- 2021
39. Lifestyle factors and risk of multimorbidity of cancer and cardiometabolic diseases: A multinational cohort study
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Freisling, H, Viallon, V, Lennon, H, Bagnardi, V, Ricci, C, Butterworth, A, Sweeting, M, Muller, D, Romieu, I, Bazelle, P, Kvaskoff, M, Arveux, P, Severi, G, Bamia, C, Kuhn, T, Kaaks, R, Bergmann, M, Boeing, H, Tjonneland, A, Olsen, A, Overvad, K, Dahm, C, Menendez, V, Agudo, A, Sanchez, M, Amiano, P, Santiuste, C, Gurrea, A, Tong, T, Schmidt, J, Tzoulaki, I, Tsilidis, K, Ward, H, Palli, D, Agnoli, C, Tumino, R, Ricceri, F, Panico, S, Picavet, H, Bakker, M, Monninkhof, E, Nilsson, P, Manjer, J, Rolandsson, O, Thysell, E, Weiderpass, E, Jenab, M, Riboli, E, Vineis, P, Danesh, J, Wareham, N, Gunter, M, Ferrari, P, Freisling H., Viallon V., Lennon H., Bagnardi V., Ricci C., Butterworth A. S., Sweeting M., Muller D., Romieu I., Bazelle P., Kvaskoff M., Arveux P., Severi G., Bamia C., Kuhn T., Kaaks R., Bergmann M., Boeing H., Tjonneland A., Olsen A., Overvad K., Dahm C. C., Menendez V., Agudo A., Sanchez M. -J., Amiano P., Santiuste C., Gurrea A. B., Tong T. Y. N., Schmidt J. A., Tzoulaki I., Tsilidis K. K., Ward H., Palli D., Agnoli C., Tumino R., Ricceri F., Panico S., Picavet H. S. J., Bakker M., Monninkhof E., Nilsson P., Manjer J., Rolandsson O., Thysell E., Weiderpass E., Jenab M., Riboli E., Vineis P., Danesh J., Wareham N. J., Gunter M. J., Ferrari P., Freisling, H, Viallon, V, Lennon, H, Bagnardi, V, Ricci, C, Butterworth, A, Sweeting, M, Muller, D, Romieu, I, Bazelle, P, Kvaskoff, M, Arveux, P, Severi, G, Bamia, C, Kuhn, T, Kaaks, R, Bergmann, M, Boeing, H, Tjonneland, A, Olsen, A, Overvad, K, Dahm, C, Menendez, V, Agudo, A, Sanchez, M, Amiano, P, Santiuste, C, Gurrea, A, Tong, T, Schmidt, J, Tzoulaki, I, Tsilidis, K, Ward, H, Palli, D, Agnoli, C, Tumino, R, Ricceri, F, Panico, S, Picavet, H, Bakker, M, Monninkhof, E, Nilsson, P, Manjer, J, Rolandsson, O, Thysell, E, Weiderpass, E, Jenab, M, Riboli, E, Vineis, P, Danesh, J, Wareham, N, Gunter, M, Ferrari, P, Freisling H., Viallon V., Lennon H., Bagnardi V., Ricci C., Butterworth A. S., Sweeting M., Muller D., Romieu I., Bazelle P., Kvaskoff M., Arveux P., Severi G., Bamia C., Kuhn T., Kaaks R., Bergmann M., Boeing H., Tjonneland A., Olsen A., Overvad K., Dahm C. C., Menendez V., Agudo A., Sanchez M. -J., Amiano P., Santiuste C., Gurrea A. B., Tong T. Y. N., Schmidt J. A., Tzoulaki I., Tsilidis K. K., Ward H., Palli D., Agnoli C., Tumino R., Ricceri F., Panico S., Picavet H. S. J., Bakker M., Monninkhof E., Nilsson P., Manjer J., Rolandsson O., Thysell E., Weiderpass E., Jenab M., Riboli E., Vineis P., Danesh J., Wareham N. J., Gunter M. J., and Ferrari P.
- Abstract
Background: Although lifestyle factors have been studied in relation to individual non-communicable diseases (NCDs), their association with development of a subsequent NCD, defined as multimorbidity, has been scarcely investigated. The aim of this study was to investigate associations between five lifestyle factors and incident multimorbidity of cancer and cardiometabolic diseases. Methods: In this prospective cohort study, 291,778 participants (64% women) from seven European countries, mostly aged 43 to 58 years and free of cancer, cardiovascular disease (CVD), and type 2 diabetes (T2D) at recruitment, were included. Incident multimorbidity of cancer and cardiometabolic diseases was defined as developing subsequently two diseases including first cancer at any site, CVD, and T2D in an individual. Multi-state modelling based on Cox regression was used to compute hazard ratios (HR) and 95% confidence intervals (95% CI) of developing cancer, CVD, or T2D, and subsequent transitions to multimorbidity, in relation to body mass index (BMI), smoking status, alcohol intake, physical activity, adherence to the Mediterranean diet, and their combination as a healthy lifestyle index (HLI) score. Cumulative incidence functions (CIFs) were estimated to compute 10-year absolute risks for transitions from healthy to cancer at any site, CVD (both fatal and non-fatal), or T2D, and to subsequent multimorbidity after each of the three NCDs. Results: During a median follow-up of 11 years, 1910 men and 1334 women developed multimorbidity of cancer and cardiometabolic diseases. A higher HLI, reflecting healthy lifestyles, was strongly inversely associated with multimorbidity, with hazard ratios per 3-unit increment of 0.75 (95% CI, 0.71 to 0.81), 0.84 (0.79 to 0.90), and 0.82 (0.77 to 0.88) after cancer, CVD, and T2D, respectively. After T2D, the 10-year absolute risks of multimorbidity were 40% and 25% for men and women, respectively, with unhealthy lifestyle, and 30% and 18% for men and
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- 2020
40. Cross-Cancer Genome-Wide Association Study of Endometrial Cancer and Epithelial Ovarian Cancer Identifies Genetic Risk Regions Associated with Risk of Both Cancers.
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Glubb D.M., Thompson D.J., Aben K.K.H., Alsulimani A., Amant F., Annibali D., Attia J., Barricarte A., Beckmann M.W., Berchuck A., Bermisheva M., Bernardini M.Q., Bischof K., Bjorge L., Bodelon C., Brand A.H., Brenton J.D., Brinton L.A., Bruinsma F., Buchanan D.D., Burghaus S., Butzow R., Cai H., Carney M.E., Chanock S.J., Chen C., Chen X.Q., Chen Z., Cook L.S., Cunningham J.M., De Vivo I., deFazio A., Doherty J.A., Dork T., du Bois A., Dunning A.M., Durst M., Edwards T., Edwards R.P., Ekici A.B., Ewing A., Fasching P.A., Ferguson S., Flanagan J.M., Fostira F., Fountzilas G., Friedenreich C.M., Gao B., Gaudet M.M., Gawelko J., Gentry-Maharaj A., Giles G.G., Glasspool R., Goodman M.T., Gronwald J., Harris H.R., Harter P., Hein A., Heitz F., Hildebrandt M.A.T., Hillemanns P., Hogdall E., Hogdall C.K., Holliday E.G., Huntsman D.G., Huzarski T., Jakubowska A., Jensen A., Jones M.E., Karlan B.Y., Karnezis A., Kelley J.L., Khusnutdinova E., Killeen J.L., Kjaer S.K., Klapdor R., Kobel M., Konopka B., Konstantopoulou I., Kopperud R.K., Koti M., Kraft P., Kupryjanczyk J., Lambrechts D., Larson M.C., Le Marchand L., Lele S., Lester J., Li A.J., Liang D., Liebrich C., Lipworth L., Lissowska J., Lu L., Lu K.H., Macciotta A., Mattiello A., May T., McAlpine J.N., McGuire V., McNeish I.A., Menon U., Modugno F., Moysich K.B., Nevanlinna H., Odunsi K., Olsson H., Orsulic S., Osorio A., Palli D., Park-Simon T.-W., Pearce C.L., Pejovic T., Permuth J.B., Podgorska A., Ramus S.J., Rebbeck T.R., Riggan M.J., Risch H.A., Rothstein J.H., Runnebaum I.B., Scott R.J., Sellers T.A., Senz J., Setiawan V.W., Siddiqui N., Sieh W., Spiewankiewicz B., Sutphen R., Swerdlow A.J., Szafron L.M., Teo S.H., Thompson P.J., Thomsen L.C.V., Titus L., Tone A., Tumino R., Turman C., Vanderstichele A., Edwards D.V., Vergote I., Vierkant R.A., Wang Z., Wang-Gohrke S., Webb P.M., White E., Whittemore A.S., Winham S.J., Wu X., Wu A.H., Yannoukakos D., Spurdle A.B., O'Mara T.A., Glubb D.M., Thompson D.J., Aben K.K.H., Alsulimani A., Amant F., Annibali D., Attia J., Barricarte A., Beckmann M.W., Berchuck A., Bermisheva M., Bernardini M.Q., Bischof K., Bjorge L., Bodelon C., Brand A.H., Brenton J.D., Brinton L.A., Bruinsma F., Buchanan D.D., Burghaus S., Butzow R., Cai H., Carney M.E., Chanock S.J., Chen C., Chen X.Q., Chen Z., Cook L.S., Cunningham J.M., De Vivo I., deFazio A., Doherty J.A., Dork T., du Bois A., Dunning A.M., Durst M., Edwards T., Edwards R.P., Ekici A.B., Ewing A., Fasching P.A., Ferguson S., Flanagan J.M., Fostira F., Fountzilas G., Friedenreich C.M., Gao B., Gaudet M.M., Gawelko J., Gentry-Maharaj A., Giles G.G., Glasspool R., Goodman M.T., Gronwald J., Harris H.R., Harter P., Hein A., Heitz F., Hildebrandt M.A.T., Hillemanns P., Hogdall E., Hogdall C.K., Holliday E.G., Huntsman D.G., Huzarski T., Jakubowska A., Jensen A., Jones M.E., Karlan B.Y., Karnezis A., Kelley J.L., Khusnutdinova E., Killeen J.L., Kjaer S.K., Klapdor R., Kobel M., Konopka B., Konstantopoulou I., Kopperud R.K., Koti M., Kraft P., Kupryjanczyk J., Lambrechts D., Larson M.C., Le Marchand L., Lele S., Lester J., Li A.J., Liang D., Liebrich C., Lipworth L., Lissowska J., Lu L., Lu K.H., Macciotta A., Mattiello A., May T., McAlpine J.N., McGuire V., McNeish I.A., Menon U., Modugno F., Moysich K.B., Nevanlinna H., Odunsi K., Olsson H., Orsulic S., Osorio A., Palli D., Park-Simon T.-W., Pearce C.L., Pejovic T., Permuth J.B., Podgorska A., Ramus S.J., Rebbeck T.R., Riggan M.J., Risch H.A., Rothstein J.H., Runnebaum I.B., Scott R.J., Sellers T.A., Senz J., Setiawan V.W., Siddiqui N., Sieh W., Spiewankiewicz B., Sutphen R., Swerdlow A.J., Szafron L.M., Teo S.H., Thompson P.J., Thomsen L.C.V., Titus L., Tone A., Tumino R., Turman C., Vanderstichele A., Edwards D.V., Vergote I., Vierkant R.A., Wang Z., Wang-Gohrke S., Webb P.M., White E., Whittemore A.S., Winham S.J., Wu X., Wu A.H., Yannoukakos D., Spurdle A.B., and O'Mara T.A.
- Abstract
BACKGROUND: Accumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide association studies (GWAS) for endometrial cancer and ovarian cancer have identified 16 and 27 risk regions, respectively, four of which overlap between the two cancers. We aimed to identify joint endometrial and ovarian cancer risk loci by performing a meta-analysis of GWAS summary statistics from these two cancers. METHOD(S): Using LDScore regression, we explored the genetic correlation between endometrial cancer and ovarian cancer. To identify loci associated with the risk of both cancers, we implemented a pipeline of statistical genetic analyses (i.e., inverse-variance meta-analysis, colocalization, and M-values) and performed analyses stratified by subtype. Candidate target genes were then prioritized using functional genomic data. RESULT(S): Genetic correlation analysis revealed significant genetic correlation between the two cancers (rG = 0.43, P = 2.66 x 10-5). We found seven loci associated with risk for both cancers (PBonferroni < 2.4 x 10-9). In addition, four novel subgenome-wide regions at 7p22.2, 7q22.1, 9p12, and 11q13.3 were identified (P < 5 x 10-7). Promoter-associated HiChIP chromatin loops from immortalized endometrium and ovarian cell lines and expression quantitative trait loci data highlighted candidate target genes for further investigation. CONCLUSION(S): Using cross-cancer GWAS meta-analysis, we have identified several joint endometrial and ovarian cancer risk loci and candidate target genes for future functional analysis. IMPACT: Our research highlights the shared genetic relationship between endometrial cancer and ovarian cancer. Further studies in larger sample sets are required to confirm our findings.Copyright ©2020 American Association for Cancer Research.
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- 2022
41. Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort.
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Rothwell, JA, Murphy, N, Bešević, J, Kliemann, N, Jenab, M, Ferrari, P, Achaintre, D, Gicquiau, A, Vozar, B, Scalbert, A, Huybrechts, I, Freisling, H, Prehn, C, Adamski, J, Cross, AJ, Pala, VM, Boutron-Ruault, M-C, Dahm, CC, Overvad, K, Gram, IT, Sandanger, TM, Skeie, G, Jakszyn, P, Tsilidis, KK, Aleksandrova, K, Schulze, MB, Hughes, DJ, van Guelpen, B, Bodén, S, Sánchez, M-J, Schmidt, JA, Katzke, V, Kühn, T, Colorado-Yohar, S, Tumino, R, Bueno-de-Mesquita, B, Vineis, P, Masala, G, Panico, S, Eriksen, AK, Tjønneland, A, Aune, D, Weiderpass, E, Severi, G, Chajès, V, Gunter, MJ, Rothwell, JA, Murphy, N, Bešević, J, Kliemann, N, Jenab, M, Ferrari, P, Achaintre, D, Gicquiau, A, Vozar, B, Scalbert, A, Huybrechts, I, Freisling, H, Prehn, C, Adamski, J, Cross, AJ, Pala, VM, Boutron-Ruault, M-C, Dahm, CC, Overvad, K, Gram, IT, Sandanger, TM, Skeie, G, Jakszyn, P, Tsilidis, KK, Aleksandrova, K, Schulze, MB, Hughes, DJ, van Guelpen, B, Bodén, S, Sánchez, M-J, Schmidt, JA, Katzke, V, Kühn, T, Colorado-Yohar, S, Tumino, R, Bueno-de-Mesquita, B, Vineis, P, Masala, G, Panico, S, Eriksen, AK, Tjønneland, A, Aune, D, Weiderpass, E, Severi, G, Chajès, V, and Gunter, MJ
- Abstract
BACKGROUND & AIMS: Colorectal cancer risk can be lowered by adherence to the World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) guidelines. We derived metabolic signatures of adherence to these guidelines and tested their associations with colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. METHODS: Scores reflecting adherence to the WCRF/AICR recommendations (scale, 1-5) were calculated from participant data on weight maintenance, physical activity, diet, and alcohol among a discovery set of 5738 cancer-free European Prospective Investigation into Cancer and Nutrition participants with metabolomics data. Partial least-squares regression was used to derive fatty acid and endogenous metabolite signatures of the WCRF/AICR score in this group. In an independent set of 1608 colorectal cancer cases and matched controls, odds ratios (ORs) and 95% CIs were calculated for colorectal cancer risk per unit increase in WCRF/AICR score and per the corresponding change in metabolic signatures using multivariable conditional logistic regression. RESULTS: Higher WCRF/AICR scores were characterized by metabolic signatures of increased odd-chain fatty acids, serine, glycine, and specific phosphatidylcholines. Signatures were inversely associated more strongly with colorectal cancer risk (fatty acids: OR, 0.51 per unit increase; 95% CI, 0.29-0.90; endogenous metabolites: OR, 0.62 per unit change; 95% CI, 0.50-0.78) than the WCRF/AICR score (OR, 0.93 per unit change; 95% CI, 0.86-1.00) overall. Signature associations were stronger in male compared with female participants. CONCLUSIONS: Metabolite profiles reflecting adherence to WCRF/AICR guidelines and additional lifestyle or biological risk factors were associated with colorectal cancer. Measuring a specific panel of metabolites representative of a healthy or unhealthy lifestyle may identify strata of the population at higher risk of colorectal cancer.
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- 2022
42. Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations
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Nimptsch, K., Aleksandrova, K., Fedirko, V., Jenab, M., Gunter, M.J., Siersema, P.D., Wu, K., Katzke, V., Kaaks, R., Panico, S., Palli, D., May, A.M., Sieri, S., Bueno-de-Mesquita, B., Standahl, K., Sánchez, M.J., Perez-Cornago, A., Olsen, A., Tjønneland, A., Bonet, C.B., Dahm, C.C., Chirlaque, M.D., Fiano, V., Tumino, R., Gurrea, A.B., Boutron-Ruault, M.C., Menegaux, F., Severi, G., Guelpen, B. van, Lee, Y.A., Pischon, T., Nimptsch, K., Aleksandrova, K., Fedirko, V., Jenab, M., Gunter, M.J., Siersema, P.D., Wu, K., Katzke, V., Kaaks, R., Panico, S., Palli, D., May, A.M., Sieri, S., Bueno-de-Mesquita, B., Standahl, K., Sánchez, M.J., Perez-Cornago, A., Olsen, A., Tjønneland, A., Bonet, C.B., Dahm, C.C., Chirlaque, M.D., Fiano, V., Tumino, R., Gurrea, A.B., Boutron-Ruault, M.C., Menegaux, F., Severi, G., Guelpen, B. van, Lee, Y.A., and Pischon, T.
- Abstract
Contains fulltext : 252185.pdf (Publisher’s version ) (Open Access), BACKGROUND: The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear. METHODS: We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort using multivariable-adjusted Cox proportional hazards regression. RESULTS: During a median follow-up of 9.3 years, 455 CRC-specific deaths were recorded, out of 590 deaths from all causes. Pre-diagnostic CRP concentrations were not associated with CRC-specific (hazard ratio, HR highest versus lowest quintile 0.92, 95% confidence interval, CI 0.66, 1.28) or all-cause mortality (HR 0.91, 95% CI 0.68, 1.21). Genetic predisposition to higher CRP (weighted score based on alleles of four CRP SNPs associated with higher circulating CRP) was not significantly associated with CRC-specific mortality (HR per CRP-score unit 0.95, 95% CI 0.86, 1.05) or all-cause mortality (HR 0.98, 95% CI 0.90, 1.07). Among four investigated CRP genetic variants, only SNP rs1205 was significantly associated with CRC-specific (comparing the CT and CC genotypes with TT genotype, HR 0.54, 95% CI 0.35, 0.83 and HR 0.58, 95% CI 0.38, 0.88, respectively) and all-cause mortality (HR 0.58, 95% CI 0.40, 0.85 and 0.64, 95% CI 0.44, 0.92, respectively). CONCLUSIONS: The results of this prospective cohort study do not support a role of pre-diagnostic CRP concentrations on mortality in individuals with CRC. The observed associations with rs1205 deserve further scientific attention.
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- 2022
43. Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations.
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Nimptsch, K, Aleksandrova, K, Fedirko, V, Jenab, M, Gunter, MJ, Siersema, PD, Wu, K, Katzke, V, Kaaks, R, Panico, S, Palli, D, May, AM, Sieri, S, Bueno-de-Mesquita, B, Standahl, K, Sánchez, M-J, Perez-Cornago, A, Olsen, A, Tjønneland, A, Bonet, CB, Dahm, CC, Chirlaque, M-D, Fiano, V, Tumino, R, Gurrea, AB, Boutron-Ruault, M-C, Menegaux, F, Severi, G, van Guelpen, B, Lee, Y-A, Pischon, T, Nimptsch, K, Aleksandrova, K, Fedirko, V, Jenab, M, Gunter, MJ, Siersema, PD, Wu, K, Katzke, V, Kaaks, R, Panico, S, Palli, D, May, AM, Sieri, S, Bueno-de-Mesquita, B, Standahl, K, Sánchez, M-J, Perez-Cornago, A, Olsen, A, Tjønneland, A, Bonet, CB, Dahm, CC, Chirlaque, M-D, Fiano, V, Tumino, R, Gurrea, AB, Boutron-Ruault, M-C, Menegaux, F, Severi, G, van Guelpen, B, Lee, Y-A, and Pischon, T
- Abstract
BACKGROUND: The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear. METHODS: We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort using multivariable-adjusted Cox proportional hazards regression. RESULTS: During a median follow-up of 9.3 years, 455 CRC-specific deaths were recorded, out of 590 deaths from all causes. Pre-diagnostic CRP concentrations were not associated with CRC-specific (hazard ratio, HR highest versus lowest quintile 0.92, 95% confidence interval, CI 0.66, 1.28) or all-cause mortality (HR 0.91, 95% CI 0.68, 1.21). Genetic predisposition to higher CRP (weighted score based on alleles of four CRP SNPs associated with higher circulating CRP) was not significantly associated with CRC-specific mortality (HR per CRP-score unit 0.95, 95% CI 0.86, 1.05) or all-cause mortality (HR 0.98, 95% CI 0.90, 1.07). Among four investigated CRP genetic variants, only SNP rs1205 was significantly associated with CRC-specific (comparing the CT and CC genotypes with TT genotype, HR 0.54, 95% CI 0.35, 0.83 and HR 0.58, 95% CI 0.38, 0.88, respectively) and all-cause mortality (HR 0.58, 95% CI 0.40, 0.85 and 0.64, 95% CI 0.44, 0.92, respectively). CONCLUSIONS: The results of this prospective cohort study do not support a role of pre-diagnostic CRP concentrations on mortality in individuals with CRC. The observed associations with rs1205 deserve further scientific attention.
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- 2022
44. Methylation-based markers of aging and lifestyle-related factors and risk of breast cancer: a pooled analysis of four prospective studies
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Dugue, P-A, Bodelon, C, Chung, FF, Brewer, HR, Ambatipudi, S, Sampson, JN, Cuenin, C, Chajes, V, Romieu, I, Fiorito, G, Sacerdote, C, Krogh, V, Panico, S, Tumino, R, Vineis, P, Polidoro, S, Baglietto, L, English, D, Severi, G, Giles, GG, Milne, RL, Herceg, Z, Garcia-Closas, M, Flanagan, JM, Southey, MC, Dugue, P-A, Bodelon, C, Chung, FF, Brewer, HR, Ambatipudi, S, Sampson, JN, Cuenin, C, Chajes, V, Romieu, I, Fiorito, G, Sacerdote, C, Krogh, V, Panico, S, Tumino, R, Vineis, P, Polidoro, S, Baglietto, L, English, D, Severi, G, Giles, GG, Milne, RL, Herceg, Z, Garcia-Closas, M, Flanagan, JM, and Southey, MC
- Abstract
BACKGROUND: DNA methylation in blood may reflect adverse exposures accumulated over the lifetime and could therefore provide potential improvements in the prediction of cancer risk. A substantial body of research has shown associations between epigenetic aging and risk of disease, including cancer. Here we aimed to study epigenetic measures of aging and lifestyle-related factors in association with risk of breast cancer. METHODS: Using data from four prospective case-control studies nested in three cohorts of European ancestry participants, including a total of 1,655 breast cancer cases, we calculated three methylation-based measures of lifestyle factors (body mass index [BMI], tobacco smoking and alcohol consumption) and seven measures of epigenetic aging (Horvath-based, Hannum-based, PhenoAge and GrimAge). All measures were regression-adjusted for their respective risk factors and expressed per standard deviation (SD). Odds ratios (OR) and 95% confidence intervals (CI) were calculated using conditional or unconditional logistic regression and pooled using fixed-effects meta-analysis. Subgroup analyses were conducted by age at blood draw, time from blood sample to diagnosis, oestrogen receptor-positivity status and tumour stage. RESULTS: None of the measures of epigenetic aging were associated with risk of breast cancer in the pooled analysis: Horvath 'age acceleration' (AA): OR per SD = 1.02, 95%CI: 0.95-1.10; AA-Hannum: OR = 1.03, 95%CI:0.95-1.12; PhenoAge: OR = 1.01, 95%CI: 0.94-1.09 and GrimAge: OR = 1.03, 95%CI: 0.94-1.12, in models adjusting for white blood cell proportions, body mass index, smoking and alcohol consumption. The BMI-adjusted predictor of BMI was associated with breast cancer risk, OR per SD = 1.09, 95%CI: 1.01-1.17. The results for the alcohol and smoking methylation-based predictors were consistent with a null association. Risk did not appear to substantially vary by age at blood draw, time to diagnosis or tumour characteristics. CONCLUSION
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- 2022
45. Epigenetic mechanisms of lung carcinogenesis involve differentially methylated CpG sites beyond those associated with smoking
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Petrovic, D, Bodinier, B, Dagnino, S, Whitaker, M, Karimi, M, Campanella, G, Haugdahl Nost, T, Polidoro, S, Palli, D, Krogh, V, Tumino, R, Sacerdote, C, Panico, S, Lund, E, Dugue, P-A, Giles, GG, Severi, G, Southey, M, Vineis, P, Stringhini, S, Bochud, M, Sandanger, TM, Vermeulen, RCH, Guida, F, Chadeau-Hyam, M, Petrovic, D, Bodinier, B, Dagnino, S, Whitaker, M, Karimi, M, Campanella, G, Haugdahl Nost, T, Polidoro, S, Palli, D, Krogh, V, Tumino, R, Sacerdote, C, Panico, S, Lund, E, Dugue, P-A, Giles, GG, Severi, G, Southey, M, Vineis, P, Stringhini, S, Bochud, M, Sandanger, TM, Vermeulen, RCH, Guida, F, and Chadeau-Hyam, M
- Abstract
Smoking-related epigenetic changes have been linked to lung cancer, but the contribution of epigenetic alterations unrelated to smoking remains unclear. We sought for a sparse set of CpG sites predicting lung cancer and explored the role of smoking in these associations. We analysed CpGs in relation to lung cancer in participants from two nested case-control studies, using (LASSO)-penalised regression. We accounted for the effects of smoking using known smoking-related CpGs, and through conditional-independence network. We identified 29 CpGs (8 smoking-related, 21 smoking-unrelated) associated with lung cancer. Models additionally adjusted for Comprehensive Smoking Index-(CSI) selected 1 smoking-related and 49 smoking-unrelated CpGs. Selected CpGs yielded excellent discriminatory performances, outperforming information provided by CSI only. Of the 8 selected smoking-related CpGs, two captured lung cancer-relevant effects of smoking that were missed by CSI. Further, the 50 CpGs identified in the CSI-adjusted model complementarily explained lung cancer risk. These markers may provide further insight into lung cancer carcinogenesis and help improving early identification of high-risk patients.
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- 2022
46. Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses.
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Dimou, N, Omiyale, W, Biessy, C, Viallon, V, Kaaks, R, O'Mara, TA, Aglago, EK, Ardanaz, E, Bergmann, MM, Bondonno, NP, Braaten, T, Colorado-Yohar, SM, Crous-Bou, M, Dahm, CC, Fortner, RT, Gram, IT, Harlid, S, Heath, AK, Idahl, A, Kvaskoff, M, Nøst, TH, Overvad, K, Palli, D, Perez-Cornago, A, Sacerdote, C, Sánchez, M-J, Schulze, MB, Severi, G, Simeon, V, Tagliabue, G, Tjønneland, A, Truong, T, Tumino, R, Johansson, M, Weiderpass, E, Murphy, N, Gunter, MJ, Lacey, B, Allen, NE, Dossus, L, Dimou, N, Omiyale, W, Biessy, C, Viallon, V, Kaaks, R, O'Mara, TA, Aglago, EK, Ardanaz, E, Bergmann, MM, Bondonno, NP, Braaten, T, Colorado-Yohar, SM, Crous-Bou, M, Dahm, CC, Fortner, RT, Gram, IT, Harlid, S, Heath, AK, Idahl, A, Kvaskoff, M, Nøst, TH, Overvad, K, Palli, D, Perez-Cornago, A, Sacerdote, C, Sánchez, M-J, Schulze, MB, Severi, G, Simeon, V, Tagliabue, G, Tjønneland, A, Truong, T, Tumino, R, Johansson, M, Weiderpass, E, Murphy, N, Gunter, MJ, Lacey, B, Allen, NE, and Dossus, L
- Abstract
BACKGROUND: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses. METHODS: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In two-sample MR analyses, genetic variants robustly associated with lifetime amount of smoking (n = 126 variants) and ever having smoked regularly (n = 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined. RESULTS: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91-1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer. CONCLUSIONS: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer. IMPACT: The results from this analysis indicate that smoking is unlikely to be causally linked with endometrial cancer risk.
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- 2022
47. Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses
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Gaziano, L, Sun, L, Arnold, M, Bell, S, Cho, K, Kaptoge, SK, Song, RJ, Burgess, S, Posner, DC, Mosconi, K, Cohen, CR, Mason, AM, Bolton, TR, Tao, R, Allara, E, Schubert, P, Chen, L, Staley, JR, Staplin, N, Altay, S, Amiano, P, Arndt, PV, Arnlov, J, Barr, ELM, Bjorkelund, C, Boer, JMA, Brenner, H, Casiglia, E, Chiodini, P, Cooper, JA, Coresh, J, Cushman, M, Dankner, R, Davidson, KW, de Jongh, RT, Donfrancesco, C, Engstrom, G, Freisling, H, de la Camara, AG, Gudnason, V, Hankey, GJ, Hansson, P, Heath, AK, Hoorn, EJ, Imano, H, Jassal, SK, Kaaks, R, Katzke, V, Kauhanen, J, Kiechl, S, Koenig, W, Kronmal, RA, Kyro, C, Lawlor, DA, Ljungberg, B, MacDonald, C, Masala, G, Meisinger, C, Melander, O, Iribas, CM, Ninomiya, T, Nitsch, D, Nordestgaard, BG, OnlandMoret, C, Palmieri, L, Petrova, D, Garcia, JRQ, Rosengren, A, Sacerdote, C, Sakurai, M, Santiuste, C, Schulze, MB, Sieri, S, Sundstrom, J, Tikhonoff, V, Tjonneland, A, Tong, T, Tumino, R, Tzoulaki, I, van der Schouw, YT, Verschuren, WMM, Volzke, H, Wallace, RB, Wannamethee, SG, Weiderpass, E, Willeit, P, Woodward, M, Yamagishi, K, ZamoraRos, R, Akwo, EA, Pyarajan, S, Gagnon, DR, Tsao, PS, Muralidhar, S, Edwards, TL, Damrauer, SM, Joseph, J, Pennells, L, Wilson, PWF, Harrison, S, Gaziano, TA, Inouye, M, Baigent, C, Casas, JP, Langenberg, C, Wareham, N, Riboli, E, Gaziano, JM, Danesh, J, Hung, AM, Butterworth, AS, Wood, AM, Di Angelantonio, E, Gaziano, L, Sun, L, Arnold, M, Bell, S, Cho, K, Kaptoge, SK, Song, RJ, Burgess, S, Posner, DC, Mosconi, K, Cohen, CR, Mason, AM, Bolton, TR, Tao, R, Allara, E, Schubert, P, Chen, L, Staley, JR, Staplin, N, Altay, S, Amiano, P, Arndt, PV, Arnlov, J, Barr, ELM, Bjorkelund, C, Boer, JMA, Brenner, H, Casiglia, E, Chiodini, P, Cooper, JA, Coresh, J, Cushman, M, Dankner, R, Davidson, KW, de Jongh, RT, Donfrancesco, C, Engstrom, G, Freisling, H, de la Camara, AG, Gudnason, V, Hankey, GJ, Hansson, P, Heath, AK, Hoorn, EJ, Imano, H, Jassal, SK, Kaaks, R, Katzke, V, Kauhanen, J, Kiechl, S, Koenig, W, Kronmal, RA, Kyro, C, Lawlor, DA, Ljungberg, B, MacDonald, C, Masala, G, Meisinger, C, Melander, O, Iribas, CM, Ninomiya, T, Nitsch, D, Nordestgaard, BG, OnlandMoret, C, Palmieri, L, Petrova, D, Garcia, JRQ, Rosengren, A, Sacerdote, C, Sakurai, M, Santiuste, C, Schulze, MB, Sieri, S, Sundstrom, J, Tikhonoff, V, Tjonneland, A, Tong, T, Tumino, R, Tzoulaki, I, van der Schouw, YT, Verschuren, WMM, Volzke, H, Wallace, RB, Wannamethee, SG, Weiderpass, E, Willeit, P, Woodward, M, Yamagishi, K, ZamoraRos, R, Akwo, EA, Pyarajan, S, Gagnon, DR, Tsao, PS, Muralidhar, S, Edwards, TL, Damrauer, SM, Joseph, J, Pennells, L, Wilson, PWF, Harrison, S, Gaziano, TA, Inouye, M, Baigent, C, Casas, JP, Langenberg, C, Wareham, N, Riboli, E, Gaziano, JM, Danesh, J, Hung, AM, Butterworth, AS, Wood, AM, and Di Angelantonio, E
- Abstract
BACKGROUND: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke. METHODS: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.8 million person-years of follow-up. Using a genetic risk score of 218 variants for estimated glomerular filtration rate (eGFR), we conducted Mendelian randomization analyses involving 413 718 participants (25 917 CHD and 8622 strokes) in EPIC-CVD, Million Veteran Program, and UK Biobank. RESULTS: There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eGFR values <60 or >105 mL·min-1·1.73 m-2, compared with those with eGFR between 60 and 105 mL·min-1·1.73 m-2. Mendelian randomization analyses for CHD showed an association among participants with eGFR <60 mL·min-1·1.73 m-2, with a 14% (95% CI, 3%-27%) higher CHD risk per 5 mL·min-1·1.73 m-2 lower genetically predicted eGFR, but not for those with eGFR >105 mL·min-1·1.73 m-2. Results were not materially different after adjustment for factors associated with the eGFR genetic risk score, such as lipoprotein(a), triglycerides, hemoglobin A1c, and blood pressure. Mendelian randomization results for stroke were nonsignificant but broadly similar to those for CHD. CONCLUSIONS: In people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches th
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- 2022
48. Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition.
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Breeur, M, Ferrari, P, Dossus, L, Jenab, M, Johansson, M, Rinaldi, S, Travis, RC, His, M, Key, TJ, Schmidt, JA, Overvad, K, Tjønneland, A, Kyrø, C, Rothwell, JA, Laouali, N, Severi, G, Kaaks, R, Katzke, V, Schulze, MB, Eichelmann, F, Palli, D, Grioni, S, Panico, S, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, B, Olsen, KS, Sandanger, TM, Nøst, TH, Quirós, JR, Bonet, C, Barranco, MR, Chirlaque, M-D, Ardanaz, E, Sandsveden, M, Manjer, J, Vidman, L, Rentoft, M, Muller, D, Tsilidis, K, Heath, AK, Keun, H, Adamski, J, Keski-Rahkonen, P, Scalbert, A, Gunter, MJ, Viallon, V, Breeur, M, Ferrari, P, Dossus, L, Jenab, M, Johansson, M, Rinaldi, S, Travis, RC, His, M, Key, TJ, Schmidt, JA, Overvad, K, Tjønneland, A, Kyrø, C, Rothwell, JA, Laouali, N, Severi, G, Kaaks, R, Katzke, V, Schulze, MB, Eichelmann, F, Palli, D, Grioni, S, Panico, S, Tumino, R, Sacerdote, C, Bueno-de-Mesquita, B, Olsen, KS, Sandanger, TM, Nøst, TH, Quirós, JR, Bonet, C, Barranco, MR, Chirlaque, M-D, Ardanaz, E, Sandsveden, M, Manjer, J, Vidman, L, Rentoft, M, Muller, D, Tsilidis, K, Heath, AK, Keun, H, Adamski, J, Keski-Rahkonen, P, Scalbert, A, Gunter, MJ, and Viallon, V
- Abstract
BACKGROUND: Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations. METHODS: We analysed targeted metabolomics data available for 5828 matched case-control pairs from cancer-specific case-control studies on breast, colorectal, endometrial, gallbladder, kidney, localized and advanced prostate cancer, and hepatocellular carcinoma nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. From pre-diagnostic blood levels of an initial set of 117 metabolites, 33 cluster representatives of strongly correlated metabolites and 17 single metabolites were derived by hierarchical clustering. The mutually adjusted associations of the resulting 50 metabolites with cancer risk were examined in penalized conditional logistic regression models adjusted for body mass index, using the data-shared lasso penalty. RESULTS: Out of the 50 studied metabolites, (i) six were inversely associated with the risk of most cancer types: glutamine, butyrylcarnitine, lysophosphatidylcholine a C18:2, and three clusters of phosphatidylcholines (PCs); (ii) three were positively associated with most cancer types: proline, decanoylcarnitine, and one cluster of PCs; and (iii) 10 were specifically associated with particular cancer types, including histidine that was inversely associated with colorectal cancer risk and one cluster of sphingomyelins that was inversely associated with risk of hepatocellular carcinoma and positively with endometrial cancer risk. CONCLUSIONS: These results could provide novel insights for the identification of pathways for cancer development, in particular those shared across different cancer types.
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- 2022
49. DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases
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Wielscher, M. (Matthias), Mandaviya, P. R. (Pooja R.), Kuehnel, B. (Brigitte), Joehanes, R. (Roby), Mustafa, R. (Rima), Robinson, O. (Oliver), Zhang, Y. (Yan), Bodinier, B. (Barbara), Walton, E. (Esther), Mishra, P. P. (Pashupati P.), Schlosser, P. (Pascal), Wilson, R. (Rory), Tsai, P.-C. (Pei-Chien), Palaniswamy, S. (Saranya), Marioni, R. E. (Riccardo E.), Fiorito, G. (Giovanni), Cugliari, G. (Giovanni), Karhunen, V. (Ville), Ghanbari, M. (Mohsen), Psaty, B. M. (Bruce M.), Loh, M. (Marie), Bis, J. C. (Joshua C.), Lehne, B. (Benjamin), Sotoodehnia, N. (Nona), Deary, I. J. (Ian J.), Chadeau-Hyam, M. (Marc), Brody, J. A. (Jennifer A.), Cardona, A. (Alexia), Selvin, E. (Elizabeth), Smith, A. K. (Alicia K.), Miller, A. H. (Andrew H.), Torres, M. A. (Mylin A.), Marouli, E. (Eirini), Gao, X. (Xin), van Meurs, J. B. (Joyce B. J.), Graf-Schindler, J. (Johanna), Rathmann, W. (Wolfgang), Koenig, W. (Wolfgang), Peters, A. (Annette), Weninger, W. (Wolfgang), Farlik, M. (Matthias), Zhang, T. (Tao), Chen, W. (Wei), Xia, Y. (Yujing), Teumer, A. (Alexander), Nauck, M. (Matthias), Grabe, H. J. (Hans J.), Doerr, M. (Macus), Lehtimaki, T. (Terho), Guan, W. (Weihua), Milani, L. (Lili), Tanaka, T. (Toshiko), Fisher, K. (Krista), Waite, L. L. (Lindsay L.), Kasela, S. (Silva), Vineis, P. (Paolo), Verweij, N. (Niek), van der Harst, P. (Pim), Iacoviello, L. (Licia), Sacerdote, C. (Carlotta), Panico, S. (Salvatore), Krogh, V. (Vittorio), Tumino, R. (Rosario), Tzala, E. (Evangelia), Matullo, G. (Giuseppe), Hurme, M. A. (Mikko A.), Raitakari, O. T. (Olli T.), Colicino, E. (Elena), Baccarelli, A. A. (Andrea A.), Kahonen, M. (Mika), Herzig, K.-H. (Karl-Heinz), Li, S. (Shengxu), BIOS consortium, Conneely, K. N. (Karen N.), Kooner, J. S. (Jaspal S.), Kottgen, A. (Anna), Heijmans, B. T. (Bastiaan T.), Deloukas, P. (Panos), Relton, C. (Caroline), Ong, K. K. (Ken K.), Bell, J. T. (Jordana T.), Boerwinkle, E. (Eric), Elliott, P. (Paul), Brenner, H. (Hermann), Beekman, M. (Marian), Levy, D. (Daniel), Waldenberger, M. (Melanie), Chambers, J. C. (John C.), Dehghan, A. (Abbas), Järvelin, M.-R. (Marjo-Riitta), Wielscher, M. (Matthias), Mandaviya, P. R. (Pooja R.), Kuehnel, B. (Brigitte), Joehanes, R. (Roby), Mustafa, R. (Rima), Robinson, O. (Oliver), Zhang, Y. (Yan), Bodinier, B. (Barbara), Walton, E. (Esther), Mishra, P. P. (Pashupati P.), Schlosser, P. (Pascal), Wilson, R. (Rory), Tsai, P.-C. (Pei-Chien), Palaniswamy, S. (Saranya), Marioni, R. E. (Riccardo E.), Fiorito, G. (Giovanni), Cugliari, G. (Giovanni), Karhunen, V. (Ville), Ghanbari, M. (Mohsen), Psaty, B. M. (Bruce M.), Loh, M. (Marie), Bis, J. C. (Joshua C.), Lehne, B. (Benjamin), Sotoodehnia, N. (Nona), Deary, I. J. (Ian J.), Chadeau-Hyam, M. (Marc), Brody, J. A. (Jennifer A.), Cardona, A. (Alexia), Selvin, E. (Elizabeth), Smith, A. K. (Alicia K.), Miller, A. H. (Andrew H.), Torres, M. A. (Mylin A.), Marouli, E. (Eirini), Gao, X. (Xin), van Meurs, J. B. (Joyce B. J.), Graf-Schindler, J. (Johanna), Rathmann, W. (Wolfgang), Koenig, W. (Wolfgang), Peters, A. (Annette), Weninger, W. (Wolfgang), Farlik, M. (Matthias), Zhang, T. (Tao), Chen, W. (Wei), Xia, Y. (Yujing), Teumer, A. (Alexander), Nauck, M. (Matthias), Grabe, H. J. (Hans J.), Doerr, M. (Macus), Lehtimaki, T. (Terho), Guan, W. (Weihua), Milani, L. (Lili), Tanaka, T. (Toshiko), Fisher, K. (Krista), Waite, L. L. (Lindsay L.), Kasela, S. (Silva), Vineis, P. (Paolo), Verweij, N. (Niek), van der Harst, P. (Pim), Iacoviello, L. (Licia), Sacerdote, C. (Carlotta), Panico, S. (Salvatore), Krogh, V. (Vittorio), Tumino, R. (Rosario), Tzala, E. (Evangelia), Matullo, G. (Giuseppe), Hurme, M. A. (Mikko A.), Raitakari, O. T. (Olli T.), Colicino, E. (Elena), Baccarelli, A. A. (Andrea A.), Kahonen, M. (Mika), Herzig, K.-H. (Karl-Heinz), Li, S. (Shengxu), BIOS consortium, Conneely, K. N. (Karen N.), Kooner, J. S. (Jaspal S.), Kottgen, A. (Anna), Heijmans, B. T. (Bastiaan T.), Deloukas, P. (Panos), Relton, C. (Caroline), Ong, K. K. (Ken K.), Bell, J. T. (Jordana T.), Boerwinkle, E. (Eric), Elliott, P. (Paul), Brenner, H. (Hermann), Beekman, M. (Marian), Levy, D. (Daniel), Waldenberger, M. (Melanie), Chambers, J. C. (John C.), Dehghan, A. (Abbas), and Järvelin, M.-R. (Marjo-Riitta)
- Abstract
We performed a multi-ethnic Epigenome Wide Association study on 22,774 individuals to describe the DNA methylation signature of chronic low-grade inflammation as measured by C-Reactive protein (CRP). We find 1,511 independent differentially methylated loci associated with CRP. These CpG sites show correlation structures across chromosomes, and are primarily situated in euchromatin, depleted in CpG islands. These genomic loci are predominantly situated in transcription factor binding sites and genomic enhancer regions. Mendelian randomization analysis suggests altered CpG methylation is a consequence of increased blood CRP levels. Mediation analysis reveals obesity and smoking as important underlying driving factors for changed CpG methylation. Finally, we find that an activated CpG signature significantly increases the risk for cardiometabolic diseases and COPD.
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- 2022
50. Excess risk of subsequent malignant neoplasms in adolescent and young adult cancer survivors: Results from the first Italian population-based cohort
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Trama, A, Tittarelli, A, Barigelletti, G, Botta, L, Gatta, G, Tagliabue, G, Contiero, P, Guzzinati, S, Andreano, A, Manneschi, G, Falcini, F, Castaing, M, Filiberti, R, Gasparotti, C, Cirilli, C, Mazzucco, W, Mangone, L, Iacovacci, S, Vitale, M, Stracci, F, Piffer, S, Tumino, R, Carone, S, Sampietro, G, Melcarne, A, Ballotari, P, Boschetti, L, Pisani, S, Cavalieri D'Oro, L, Cuccaro, F, D'Argenzio, A, D'Orsi, G, Fanetti, A, Ardizzone, A, Candela, G, Savoia, F, Pascucci, C, Castelli, M, Storchi, C, Bernasconi, A, Trama, Annalisa, Tittarelli, Andrea, Barigelletti, Giulio, Botta, Laura, Gatta, Gemma, Tagliabue, Giovanna, Contiero, Paolo, Guzzinati, Stefano, Andreano, Anita, Manneschi, Gianfranco, Falcini, Fabio, Castaing, Marine, Filiberti, Rosa A, Gasparotti, Cinzia, Cirilli, Claudia, Mazzucco, Walter, Mangone, Lucia, Iacovacci, Silvia, Vitale, Maria F, Stracci, Fabrizio, Piffer, Silvano, Tumino, Rosario, Carone, Simona, Sampietro, Giuseppe, Melcarne, Anna, Ballotari, Paola, Boschetti, Lorenza, Pisani, Salvatore, Cavalieri D'Oro, Luca, Cuccaro, Francesco, D'Argenzio, Angelo, D'Orsi, Giancarlo, Fanetti, Anna C, Ardizzone, Antonino, Candela, Giuseppa, Savoia, Fabio, Pascucci, Cristiana, Castelli, Maurizio, Storchi, Cinzia, Bernasconi, Alice, Trama, A, Tittarelli, A, Barigelletti, G, Botta, L, Gatta, G, Tagliabue, G, Contiero, P, Guzzinati, S, Andreano, A, Manneschi, G, Falcini, F, Castaing, M, Filiberti, R, Gasparotti, C, Cirilli, C, Mazzucco, W, Mangone, L, Iacovacci, S, Vitale, M, Stracci, F, Piffer, S, Tumino, R, Carone, S, Sampietro, G, Melcarne, A, Ballotari, P, Boschetti, L, Pisani, S, Cavalieri D'Oro, L, Cuccaro, F, D'Argenzio, A, D'Orsi, G, Fanetti, A, Ardizzone, A, Candela, G, Savoia, F, Pascucci, C, Castelli, M, Storchi, C, Bernasconi, A, Trama, Annalisa, Tittarelli, Andrea, Barigelletti, Giulio, Botta, Laura, Gatta, Gemma, Tagliabue, Giovanna, Contiero, Paolo, Guzzinati, Stefano, Andreano, Anita, Manneschi, Gianfranco, Falcini, Fabio, Castaing, Marine, Filiberti, Rosa A, Gasparotti, Cinzia, Cirilli, Claudia, Mazzucco, Walter, Mangone, Lucia, Iacovacci, Silvia, Vitale, Maria F, Stracci, Fabrizio, Piffer, Silvano, Tumino, Rosario, Carone, Simona, Sampietro, Giuseppe, Melcarne, Anna, Ballotari, Paola, Boschetti, Lorenza, Pisani, Salvatore, Cavalieri D'Oro, Luca, Cuccaro, Francesco, D'Argenzio, Angelo, D'Orsi, Giancarlo, Fanetti, Anna C, Ardizzone, Antonino, Candela, Giuseppa, Savoia, Fabio, Pascucci, Cristiana, Castelli, Maurizio, Storchi, Cinzia, and Bernasconi, Alice
- Abstract
Background: Evidence about late effects in adolescent and young adult (AYA) cancer survivors is scarce. This study assessed the risk of subsequent malignant neoplasms (SMNs) to identify the most common SMNs to be considered in follow-up care. Methods: Population-based cancer registries retrospectively identified first primary tumors (between 1976 and 2013) and SMNs in AYAs (15-39 years old at their cancer diagnosis). AYA cancer survivors were those alive at least 5 years after their first cancer diagnosis. The excess risk of SMNs was measured as standardized incidence ratios (SIRs) and absolute excess risk together with the cumulative incidence of SMNs. Results: The cohort included 67,692 AYA cancer survivors. The excess risk of developing any SMN (SIR, 1.6; 95% confidence interval, 1.5-1.7) was 60%. The excess risk of SMNs was significantly high for survivors of lymphomas; cancers of the breast, thyroid, female genital tract, digestive organs, gonads, and urinary tract; and melanomas. The cumulative incidence of all SMNs in AYA cancer survivors within 25 years of their first cancer diagnosis was approximately 10%. Subsequent tumors contributing to approximately 60% of all SMNs were breast cancer, colorectal cancer, corpus uteri cancer, and ovarian cancer in females and colorectal cancer, bladder cancer, prostate cancer, lung cancer, and lymphomas in males. Conclusions: These results highlight the need to personalize follow-up strategies for AYA cancer survivors.
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- 2022
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