Search

Your search keyword '"TYLER, NICHOLE S."' showing total 19 results
Start Over Author "TYLER, NICHOLE S."
19 results on '"TYLER, NICHOLE S."'

2. Combining uncertainty-aware predictive modeling and a bedtime Smart Snack intervention to prevent nocturnal hypoglycemia in people with type 1 diabetes on multiple daily injections

Author

Mosquera-Lopez, Clara, primary, Roquemen-Echeverri, Valentina, additional, Tyler, Nichole S, additional, Patton, Susana R, additional, Clements, Mark A, additional, Martin, Corby K, additional, Riddell, Michael C, additional, Gal, Robin L, additional, Gillingham, Melanie, additional, Wilson, Leah M, additional, Castle, Jessica R, additional, and Jacobs, Peter G, additional

Published
2023
Full Text
View/download PDF

3. Combining uncertainty-aware predictive modeling and a bedtime Smart Snack intervention to prevent nocturnal hypoglycemia in people with type 1 diabetes on multiple daily injections.

Author

Mosquera-Lopez, Clara, Roquemen-Echeverri, Valentina, Tyler, Nichole S, Patton, Susana R, Clements, Mark A, Martin, Corby K, Riddell, Michael C, Gal, Robin L, Gillingham, Melanie, Wilson, Leah M, Castle, Jessica R, and Jacobs, Peter G

Abstract

Objective Nocturnal hypoglycemia is a known challenge for people with type 1 diabetes, especially for physically active individuals or those on multiple daily injections. We developed an evidential neural network (ENN) to predict at bedtime the probability and timing of nocturnal hypoglycemia (0-4 vs 4-8 h after bedtime) based on several glucose metrics and physical activity patterns. We utilized these predictions in silico to prescribe bedtime carbohydrates with a Smart Snack intervention specific to the predicted minimum nocturnal glucose and timing of nocturnal hypoglycemia. Materials and methods We leveraged free-living datasets collected from 366 individuals from the T1DEXI Study and Glooko. Inputs to the ENN used to model nocturnal hypoglycemia were derived from demographic information, continuous glucose monitoring, and physical activity data. We assessed the accuracy of the ENN using area under the receiver operating curve, and the clinical impact of the Smart Snack intervention through simulations. Results The ENN achieved an area under the receiver operating curve of 0.80 and 0.71 to predict nocturnal hypoglycemic events during 0-4 and 4-8 h after bedtime, respectively, outperforming all evaluated baseline methods. Use of the Smart Snack intervention reduced probability of nocturnal hypoglycemia from 23.9 ± 14.1% to 14.0 ± 13.3% and duration from 7.4 ± 7.0% to 2.4 ± 3.3% in silico. Discussion Our findings indicate that the ENN-based Smart Snack intervention has the potential to significantly reduce the frequency and duration of nocturnal hypoglycemic events. Conclusion A decision support system that combines prediction of minimum nocturnal glucose and proactive recommendations for bedtime carbohydrate intake might effectively prevent nocturnal hypoglycemia and reduce the burden of glycemic self-management. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

4. Assessment of a Decision Support System for Adults with Type 1 Diabetes on Multiple Daily Insulin Injections

Author

Castle, Jessica R., primary, Wilson, Leah M., additional, Tyler, Nichole S., additional, Espinoza, Alejandro Z., additional, Mosquera-Lopez, Clara M., additional, Kushner, Taisa, additional, Young, Gavin M., additional, Pinsonault, Joseph, additional, Dodier, Robert H., additional, Hilts, Wade W., additional, Oganessian, Sos M., additional, Branigan, Deborah L., additional, Gabo, Virginia B., additional, Eom, Jae H., additional, Ramsey, Katrina, additional, Youssef, Joseph El, additional, Cafazzo, Joseph A., additional, Winters-Stone, Kerri, additional, and Jacobs, Peter G., additional

Published
2022
Full Text
View/download PDF

5. 771-P: Acceptance of Decision Support Recommendations Improves Time in Range for People Living with Type 1 Diabetes on Multiple Daily Injections

Author

CASTLE, JESSICA R., primary, ESPINOZA, ALEJANDRO Z., additional, TYLER, NICHOLE S., additional, WILSON, LEAH M., additional, MOSQUERA-LOPEZ, CLARA M., additional, PINSONAULT, JOSEPH, additional, DODIER, ROBERT, additional, OGANESSIAN, SOS M., additional, BRANIGAN, DEBORAH, additional, GABO, VIRGINIA, additional, EOM, JAE H., additional, EL YOUSSEF, JOSEPH, additional, RAMSEY, KATRINA, additional, KUSHNER, TAISA, additional, WINTERS-STONE, KERRI, additional, CAFAZZO, JOSEPH A., additional, and JACOBS, PETER G., additional

Published
2022
Full Text
View/download PDF

6. 240-OR: Quantifying Glucose Utilization and Endogenous Glucose Production during Resistance Exercise in People with Type 1 Diabetes (T1D)

Author

YOUNG, GAVIN, primary, JACOBS, PETER G., additional, TYLER, NICHOLE S., additional, NGUYEN, THANH-TIN P., additional, CASTLE, JESSICA R., additional, WILSON, LEAH M., additional, BRANIGAN, DEBORAH, additional, GABO, VIRGINIA, additional, GUILLOT, FLORIAN H., additional, RIDDELL, MICHAEL, additional, and YOUSSEF, JOSEPH EL, additional

Published
2022
Full Text
View/download PDF

7. 291-OR: Using the Performance in Exercise and Knowledge (PEAK) Guidelines Incorporated in a Smartphone-Based Decision Support System Improves Glucose Outcomes during Free-Living Exercise

Author

WILSON, LEAH M., primary, JACOBS, PETER G., additional, GUILLOT, FLORIAN H., additional, TYLER, NICHOLE S., additional, KUSHNER, TAISA, additional, ESPINOZA, ALEJANDRO Z., additional, MOSQUERA-LOPEZ, CLARA M., additional, PINSONAULT, JOSEPH, additional, DODIER, ROBERT, additional, OGANESSIAN, SOS M., additional, BRANIGAN, DEBORAH, additional, GABO, VIRGINIA, additional, EOM, JAE H., additional, YOUSSEF, JOSEPH EL, additional, WINTERS-STONE, KERRI, additional, and CASTLE, JESSICA R., additional

Published
2022
Full Text
View/download PDF

10. Measuring glucose at the site of insulin delivery with a redox-mediated sensor

Author

Jacobs, Peter G., primary, Tyler, Nichole S., additional, Vanderwerf, Scott M., additional, Mosquera-Lopez, Clara, additional, Seidl, Thomas, additional, Cargill, Robert, additional, Branigan, Deborah, additional, Ramsey, Katrina, additional, Morris, Kristin, additional, Benware, Sheila, additional, Ward, W. Kenneth, additional, and Castle, Jessica R., additional

Published
2020
Full Text
View/download PDF

12. Dual-Hormone Closed-Loop System Using a Liquid Stable Glucagon Formulation Versus Insulin-Only Closed-Loop System Compared With a Predictive Low Glucose Suspend System: An Open-Label, Outpatient, Single-Center, Crossover, Randomized Controlled Trial

Author

Wilson, Leah M., primary, Jacobs, Peter G., additional, Ramsey, Katrina L., additional, Resalat, Navid, additional, Reddy, Ravi, additional, Branigan, Deborah, additional, Leitschuh, Joseph, additional, Gabo, Virginia, additional, Guillot, Florian, additional, Senf, Brian, additional, El Youssef, Joseph, additional, Steineck, Isabelle Isa Kristin, additional, Tyler, Nichole S., additional, and Castle, Jessica R., additional

Published
2020
Full Text
View/download PDF

15. 1051-P: Improving Glycemic Outcomes in T1D Using an Automated Decision Support Recommender System: Evaluation In Silico and Compared with Physician Recommendations

Author

TYLER, NICHOLE S., primary, MOSQUERA-LOPEZ, CLARA M., additional, WILSON, LEAH M., additional, RESALAT, NAVID, additional, DODIER, ROBERT, additional, BRANIGAN, DEBORAH, additional, GABO, VIRGINIA, additional, YOUSSEF, JOSEPH EL, additional, CASTLE, JESSICA R., additional, and JACOBS, PETER G., additional

Published
2019
Full Text
View/download PDF

19. Quantifying insulin-mediated and noninsulin-mediated changes in glucose dynamics during resistance exercise in type 1 diabetes.

Author

Young GM, Jacobs PG, Tyler NS, Nguyen TP, Castle JR, Wilson LM, Branigan D, Gabo V, Guillot FH, Riddell MC, and El Youssef J

Subjects
Humans, Glucose, Insulin, Blood Glucose, Exercise, Lactic Acid, Diabetes Mellitus, Type 1, Resistance Training, Hypoglycemia
Abstract

Exercise can cause dangerous fluctuations in blood glucose in people living with type 1 diabetes (T1D). Aerobic exercise, for example, can cause acute hypoglycemia secondary to increased insulin-mediated and noninsulin-mediated glucose utilization. Less is known about how resistance exercise (RE) impacts glucose dynamics. Twenty-five people with T1D underwent three sessions of either moderate or high-intensity RE at three insulin infusion rates during a glucose tracer clamp. We calculated time-varying rates of endogenous glucose production (EGP) and glucose disposal (R d ) across all sessions and used linear regression and extrapolation to estimate insulin- and noninsulin-mediated components of glucose utilization. Blood glucose did not change on average during exercise. The area under the curve (AUC) for EGP increased by 1.04 mM during RE (95% CI: 0.65-1.43, P < 0.001) and decreased proportionally to insulin infusion rate (0.003 mM per percent above basal rate, 95% CI: 0.001-0.006, P = 0.003). The AUC for R d rose by 1.26 mM during RE (95% CI: 0.41-2.10, P = 0.004) and increased proportionally with insulin infusion rate (0.04 mM per percent above basal rate, CI: 0.03-0.04, P < 0.001). No differences were observed between the moderate and high resistance groups. Noninsulin-mediated glucose utilization rose significantly during exercise before returning to baseline roughly 30-min postexercise. Insulin-mediated glucose utilization remained unchanged during exercise sessions. Circulating catecholamines and lactate rose during exercise despite relatively small changes observed in R d . Results provide an explanation of why RE may pose a lower overall risk for hypoglycemia. NEW & NOTEWORTHY Aerobic exercise is known to cause decreases in blood glucose secondary to increased glucose utilization in people living with type 1 diabetes (T1D). However, less is known about how resistance-type exercise impacts glucose dynamics. Twenty-five participants with T1D performed in-clinic weight-bearing exercises under a glucose clamp. Mathematical modeling of infused glucose tracer allowed for quantification of the rate of hepatic glucose production as well as rates of insulin-mediated and noninsulin-mediated glucose uptake experienced during resistance exercise.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results