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3. Seroprevalence of human adenovirus type 5 neutralizing antibodies in the Philippines.

Author

Francisco, Abialbon G., Reyes, John Carlo B., Tabios, Ian Kim B., Cruz, Criselda Jean G., Ang, Mark Angelo C., Heralde III, Francisco M., Lacuna, Azita Racquel G., and de Paz-Silava, Sheriah Laine M.

Subjects
ADENOVIRUSES, BOOSTER vaccines, VACCINE effectiveness, SEROPREVALENCE, IMMUNE response, VACCINE development, MATERNALLY acquired immunity, IMMUNOGLOBULINS
Abstract

Human adenovirus (HAdV), particularly the HAdV type 5 (HAdV-5), has been extensively utilized in the development of vector vaccines due to its high immunogenicity, good safety profile, and ease of propagation. However, one of the main challenges in its use is the presence of pre-existing immunity among vaccine recipients. Pre-existing neutralizing antibodies (NAbs) can prevent the uptake of HAdV-5 vectors and reduce vaccine efficacy. Hence, this study investigated the seroprevalence of NAbs against HAdV-5 in urban and rural regions of the Philippines. Luciferase-based neutralization assay was performed on 391 plasma/serum samples. Out of these samples, 346 or 88.5% were positive for HAdV-5 NAbs, and the majority of them (56.8%) had high titers against the virus. Among the regions included in this study, Bicol (Region V) had the highest seroprevalence rate (94.1%). Our findings show that a significant number of adults in the Philippines have pre-existing immunity against HAdV-5. This supports the recommendation that vaccination programs in the country should consider implementing vaccination techniques, such as a prime-boost regimen or addition of booster doses, to address the potential negative effects of pre-existing HAdV-5 immunity in the efficacy of adenoviral vector-based vaccines. [ABSTRACT FROM AUTHOR]

Published
2023
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4. Determinants of Acquisition, Persistence, and Clearance of Oncogenic Cervical Human Papillomavirus Infection in the Philippines Using a Multi-Omics Approach: DEFEAT HPV Study Protocol

Author

de Paz-Silava, Sheriah Laine M., primary, Tabios, Ian Kim B., additional, Tantengco, Ourlad Alzeus G., additional, Climacosa, Fresthel Monica M., additional, Velayo, Clarissa L., additional, Lintao, Ryan C. V., additional, Cando, Leslie Faye T., additional, Perias, Glenmarie Angelica S., additional, Idolor, Maria Isabel C., additional, Francisco, Abialbon G., additional, Catral, Charlene Divine M., additional, Chiong, Charlotte M., additional, and Dalmacio, Leslie Michele M., additional

Published
2023
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6. Circulating microRNAs as Biomarkers of Hepatic Fibrosis in Schistosomiasis Japonica Patients in the Philippines

Author

Tabios, Ian Kim B., primary, Sato, Marcello Otake, additional, Tantengco, Ourlad Alzeus Gaddi, additional, Fornillos, Raffy Jay C., additional, Kirinoki, Masashi, additional, Sato, Megumi, additional, Rojo, Raniv D., additional, Fontanilla, Ian Kendrich C., additional, Chigusa, Yuichi, additional, Medina, Paul Mark B., additional, Kikuchi, Mihoko, additional, and Leonardo, Lydia R., additional

Published
2022
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8. Diagnostic Performance of Parasitological, Immunological, Molecular, and Ultrasonographic Tests in Diagnosing Intestinal Schistosomiasis in Fieldworkers From Endemic Municipalities in the Philippines

Author

Tabios, Ian Kim B., primary, Sato, Marcello Otake, additional, Tantengco, Ourlad Alzeus G., additional, Fornillos, Raffy Jay C., additional, Kirinoki, Masashi, additional, Sato, Megumi, additional, Rojo, Raniv D., additional, Fontanilla, Ian Kendrich C., additional, Chigusa, Yuichi, additional, Medina, Paul Mark B., additional, Kikuchi, Mihoko, additional, and Leonardo, Lydia R., additional

Published
2022
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9. Oncomelania hupensis quadrasi: Snail intermediate host of Schistosoma japonicum in the Philippines

Author

Leonardo, Lydia, primary, Varona, Gracia, additional, Fornillos, Raffy Jay, additional, Manalo, Daria, additional, Tabios, Ian Kim, additional, Moendeg, Kharleezelle, additional, de Cadiz, Aleyla, additional, Kikuchi, Mihoko, additional, Chigusa, Yuichi, additional, Mistica, Myra, additional, Hernandez, Leda, additional, Palasi, Winston, additional, and Fontanilla, Ian Kendrich, additional

Published
2020
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10. Current status of neglected tropical diseases (NTDs) in the Philippines

Author

Leonardo, Lydia, primary, Hernandez, Leda, additional, Magturo, Theodora Cecile, additional, Palasi, Winston, additional, Rubite, Julie Mart, additional, de Cadiz, Aleyla, additional, Moendeg, Kharleezelle, additional, Fornillos, Raffy Jay, additional, Tabios, Ian Kim, additional, Mistica, Myra, additional, and Fontanilla, Ian Kendrich, additional

Published
2020
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11. Detection of Schistosoma japonicum and Oncomelania hupensis quadrasi environmental DNA and its potential utility to schistosomiasis japonica surveillance in the Philippines

Author

Fornillos, Raffy Jay C., primary, Sato, Marcello Otake, additional, Tabios, Ian Kim B., additional, Sato, Megumi, additional, Leonardo, Lydia R., additional, Chigusa, Yuichi, additional, Minamoto, Toshifumi, additional, Kikuchi, Mihoko, additional, Legaspi, Emelda R., additional, and Fontanilla, Ian Kendrich C., additional

Published
2019
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12. Analysis of Environmental DNA and Edaphic Factors for the Detection of the Snail Intermediate Host Oncomelania hupensis quadrasi

Author

Calata, Fritz Ivy C., primary, Caranguian, Camille Z., additional, Mendoza, Jillian Ela M., additional, Fornillos, Raffy Jay C., additional, Tabios, Ian Kim B., additional, Fontanilla, Ian Kendrich C., additional, Leonardo, Lydia R., additional, Sunico, Louie S., additional, Kawai, Satoru, additional, Chigusa, Yuichi, additional, Kikuchi, Mihoko, additional, Sato, Megumi, additional, Minamoto, Toshifumi, additional, Baoanan, Zenaida G., additional, and Sato, Marcello Otake, additional

Published
2019
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13. Genetic Comparison of Oncomelania hupensis quadrasi (Möllendorf, 1895) (Gastropoda: Pomatiopsidae), the Intermediate Host of Schistosoma japonicum in the Philippines, Based on 16S Ribosomal RNA Sequence.

Author

Chua, James Christopher C., Tabios, Ian Kim B., Tamayo, Pebbles Grayle P., Leonardo, Lyd ia R., Fontanilla, Ian Kendrich C., Fornillos, Raffy Jay C., De Chavez, Emmanuel Ryan C., Agatsuma, Takeshi, Mihoko Kikuchi, Naoko Kato-Hayashi, and Yuichi Chigusa

Subjects
*SCHISTOSOMA japonicum, *RNA sequencing, *PARASITES
Abstract

Schistosomiasis japonica is a water-borne trematode infection transmitted by different subspecies of Oncomelania hupensis. As parasites may either co-evolve or locally adapt with their hosts, snail diversity, as revealed by morphometric and genetic studies, may reflect parasite diversity and elucidate snail susceptibility and transmission patterns. This study aimed to compare isolates of O. h. quadrasi based on a 342-bp fragment of the 16S ribosomal RNA gene. O. h. quadrasi isolates were collected from nine provinces known to have S. japonicum in the Philippines, namely Cagayan Valley, Bohol, Negros Occidental, Leyte, Davao, Davao del Sur, Mindoro Oriental, Northern Samar, and Sorsogon. O. h. hupensis and O. h. nosophora isolates were also collected from China and Japan, respectively. The 16S ribosomal RNA gene of each specimen was amplif ied and sequenced. Phylogenetic and network analyses based on the 221 16S rRNA gene sequences revealed that O. h. quadrasi clustered as a distinct clade from the two other subspecies. Of the four identif ied haplotypes for O. h. quadrasi, two haplotypes were from Negros Oriental (Ohq2 and Ohq3), and one haplotype was from Bohol (Ohq4). The isolates from the remaining seven provinces shared a common haplotype (Ohq1). The current study was able to show the relationship among O. hupensis subspecies and demonstrate the limited ability of mitochondrial 16S ribosomal molecular marker in differentiating O. h. quadrasi geographic strains in the Philippines. [ABSTRACT FROM AUTHOR]

Published
2017

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