212 results on '"Tachibana, Keisuke"'
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2. Japanese Regulatory Considerations for Interoperability of Medical Devices
3. A doxycycline-inducible CYP3A4-Caco-2 cell line as a model for evaluating safety of aflatoxin B1 in the human intestine
4. Safety evaluation of MA-T after ingestion in mice
5. Association of Plasma Claudin-5 with Age and Alzheimer Disease
6. Safety and efficacy of an anti-claudin-5 monoclonal antibody to increase blood–brain barrier permeability for drug delivery to the brain in a non-human primate
7. Legislation on the Roles of the Pharmacist and Pharmacy in the Revision of the Pharmaceutical and Medical Device Act and the Pharmacists Act in Japan
8. Tight junction modulators for drug delivery to the central nervous system
9. Development of APOC3 antisense oligonucleotide for broader dyslipidemia
10. The Clinical Innovation Network: a policy for promoting development of drugs and medical devices in Japan
11. A Method to Prepare a Bioprobe for Regulatory Science of the Drug Delivery System to the Brain: An Angulin Binder to Modulate Tricellular Tight Junction-Seal
12. Activation of Peroxisome Proliferator-Activated Receptor δ Induces Fatty Acid β-Oxidation in Skeletal Muscle and Attenuates Metabolic Syndrome
13. New Japanese Regulatory Frameworks for Post-Marketing Management of Pharmaceutical Products
14. Structural Basis for PPARα Activation by 1H-pyrazolo-[3,4-b]pyridine Derivatives
15. A Method to Prepare Claudin-Modulating Recombinant Proteins
16. SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression
17. Homoharringtonine is a transdermal granular permeation enhancer
18. Abstract 18674: Development of Antisense Drug Targeting PCSK9
19. Modifying the blood–brain barrier by targeting claudin‐5: Safety and risks
20. Exploring compounds to be used as cosmetic agents that activate peroxisome proliferator‐activated receptor alpha
21. Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides
22. Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood–Brain Barrier
23. Facilitation of adipocyte differentiation of 3T3-L1 cells by debrominated tetrabromobisphenol A compounds detected in Japanese breast milk
24. Overview of the Premarketing and Postmarketing Requirements for Drugs Granted Japanese Conditional Marketing Approval
25. Design and In Vitro Evaluation of Splice-Switching Oligonucleotides Bearing Locked Nucleic Acids, Amido-Bridged Nucleic Acids, and Guanidine-Bridged Nucleic Acids
26. Design and evaluation of locked nucleic acid-based splice-switching oligonucleotides in vitro
27. Human mannose-binding lectin 2 is directly regulated by peroxisome proliferator-activated receptors via a peroxisome proliferator responsive element
28. Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A Review
29. The Roadmap to Approval under Japan’s Two-Track Regulatory System: Comparing Six Regenerative Medical Products
30. Legislation on the Roles of the Pharmacist and Pharmacy in the Revision of the Pharmaceutical and Medical Device Act and the Pharmacists Act in Japan
31. Activation of peroxisome proliferator-activated receptor [delta] induces fatty acid [beta]-oxidation in skeletal muscle and attenuates metabolic syndrome
32. Structural development of 1H-pyrazolo-[3,4-b]pyridine-4-carboxylic acid derivatives as human peroxisome proliferator-activated receptor alpha (PPARα)-selective agonists
33. Radiolabeled cCPE Peptides for SPECT Imaging of Claudin-4 Overexpression in Pancreatic Cancer
34. A Concept for a Japanese Regulatory Framework for Emerging Medical Devices with Frequently Modified Behavior
35. Therapeutic innovation and regulatory sciences for paracellular absorption enhancers for biologics
36. Development of a novel peroxisome proliferator-activated receptor alpha activator to treat nonalcoholic steatohepatitis
37. Japanese Regulatory Considerations for Interoperability of Medical Devices
38. Potential for Tight Junction Protein–Directed Drug Development Using Claudin Binders and Angubindin-1
39. A Review of the Regulatory Framework for Initiation and Acceleration of Patient Access to Innovative Medical Products in Japan
40. Development of a Ligand Screening Tool Using Full-Length Human Peroxisome Proliferator-Activated Receptor-Expressing Cell Lines to Ameliorate Metabolic Syndrome
41. Lipin-1 is a novel substrate of protein phosphatase PGAM5
42. Enhancement of exon skipping activity by reduction in the secondary structure content of LNA-based splice-switching oligonucleotides
43. Anti-Claudin Antibodies as a Concept for Development of Claudin-Directed Drugs
44. Perspectives on tight junctions-related skin diseases and their pharmaceutical affairs
45. Radiolabeled cCPE Peptides for SPECT Imaging of Claudin-4 Overexpression in Pancreatic Cancer.
46. Preclinical Pharmacology and Safety Studies of GalNAc-conjugated Antisense Oligonucleotides Targeting Human PCSK9
47. Discovery of peroxisome proliferator–activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line
48. Construction of a tri-chromatic reporter cell line for the rapid and simple screening of splice-switching oligonucleotides targeting DMD exon 51 using high content screening
49. Efficacy and safety of antisense drug targeting PCSK9 in non human primates
50. IL-1β-Induced Downregulation of the Multifunctional PDZ Adaptor PDZK1 Is Attenuated by ERK Inhibition, RXRα, or PPARα Stimulation in Enterocytes
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