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Your search keyword '"Tachiwada, Tokushi"' showing total 15 results
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15 results on '"Tachiwada, Tokushi"'

4. Human ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane

Author

Paterson, Jill K., Shukla, Suneet, Black, Chelsea M., Tachiwada, Tokushi, Garfield, Susan, Wincovitch, Stephen, Ernst, David N., Agadir, Anissa, Ambudkar, Suresh V., Xuelin Li, Szakacs, Gergely, Shin-ichi Akiyama, and Gottesman, Michael M.

Subjects
Mitochondrial membranes -- Research, Cell membranes -- Research, Biological sciences, Chemistry
Abstract

The investigation of two distinct molecular weight forms of human ABCB6 was observed to be localized to both the outer mitochondrial membrane and the plasma membrane and plays a functional role in the plasma membrane.

Published
2007

5. Surgical Treatment of a Giant Liposarcoma in a Japanese Man

Author

Hashimoto, Yasuhiro, Hatakeyama, Shingo, Tachiwada, Tokushi, Yoneyama, Takahiro, Koie, Takuya, Kamimura, Noritaka, Yanagisawa, Takeshi, Hakamada, Kenichi, and Ohyama, Chikara

Subjects
body regions, Article Subject, neoplasms
Abstract

We report a case of a rapidly progressing giant retroperitoneal liposarcoma weighing 22 kg in a 41-year-old Japanese man, successfully treated with surgical excision. To our knowledge, this is the largest liposarcoma in the Japanese population reported in the literature.

Published
2010
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6. Tumor suppressive microRNA-1 mediated novel apoptosis pathways through direct inhibition of splicing factor serine/arginine-rich 9 (SRSF9/SRp30c) in bladder cancer

Author

Yoshino, Hirofumi, primary, Enokida, Hideki, additional, Chiyomaru, Takeshi, additional, Tatarano, Shuichi, additional, Hidaka, Hideo, additional, Yamasaki, Takeshi, additional, Gotannda, Takenari, additional, Tachiwada, Tokushi, additional, Nohata, Nijiro, additional, Yamane, Takashi, additional, Seki, Naohiko, additional, and Nakagawa, Masayuki, additional

Published
2012
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7. Novel oncogenic function of mesoderm development candidate 1 and its regulation by MiR-574-3p in bladder cancer cell lines

Author

TATARANO, SHUICHI, primary, CHIYOMARU, TAKESHI, additional, KAWAKAMI, KAZUMORI, additional, ENOKIDA, HIDEKI, additional, YOSHINO, HIROFUMI, additional, HIDAKA, HIDEO, additional, NOHATA, NIJIRO, additional, YAMASAKI, TAKESHI, additional, GOTANDA, TAKENARI, additional, TACHIWADA, TOKUSHI, additional, SEKI, NAOHIKO, additional, and NAKAGAWA, MASAYUKI, additional

Published
2011
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8. 1702 PHASE 2 TRIAL OF NEOADJUVANT GEMCITABINE AND CARBOPLATIN FOR MUSCLE-INVASIVE BLADDER CANCER FOLLOWED BY RADICAL CYSTECTOMY

Author

Koie, Takuya, primary, Okamoto, Teppei, additional, Imanishi, Kengo, additional, Sugiyama, Naoki, additional, Kudoh, Shigemasa, additional, Mori, Kazuyuki, additional, Tachiwada, Tokushi, additional, Yoneyama, Takahiro, additional, Hashimoto, Yasuhiro, additional, Kamimura, Noritaka, additional, Ohyama, Chikara, additional, and Suzuki, Yuichiro, additional

Published
2010
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9. Isolation and characterization of arsenite-resistant human epidermoid carcinoma KB cells

Author

Tachiwada, Tokushi, primary, Chen, Zhe-Sheng, additional, Che, Xiao-Fang, additional, Matsumoto, Mitsugu, additional, Haraguchi, Misako, additional, Gotanda, Takenari, additional, Sumizawa, Tomoyuki, additional, Furukawa, Tatsuhiko, additional, Nishiyama, Kenryu, additional, Seki, Naohiko, additional, Yamamoto, Masatatsu, additional, Nakagawa, Masayuki, additional, and Akiyama, Shin-Ichi, additional

Published
2007
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12. Molecular basis for the involvement of thymidine phosphorylase in cancer invasion

Author

Gotanda, Takenari, primary, Haraguchi, Misako, additional, Tachiwada, Tokushi, additional, Shinkura, Reiko, additional, Koriyama, Chihaya, additional, Akiba, Suminori, additional, Kawahara, Motoshi, additional, Nishiyama, Kenryu, additional, Sumizawa, Tomoyuki, additional, Furukawa, Tatsuhiko, additional, Mimata, Hiromitsu, additional, Nomura, Yoshio, additional, Akiyama, Shin-ichi, additional, and Nakagawa, Masayuki, additional

Published
2006
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13. Targeted Deletion of Both Thymidine Phosphorylase and Uridine Phosphorylase and Consequent Disorders in Mice

Author

Haraguchi, Misako, primary, Tsujimoto, Hiroaki, additional, Fukushima, Masakazu, additional, Higuchi, Itsuro, additional, Kuribayashi, Hideto, additional, Utsumi, Hideo, additional, Nakayama, Atsuo, additional, Hashizume, Yoshio, additional, Hirato, Junko, additional, Yoshida, Hiroki, additional, Hara, Hiromitsu, additional, Hamano, Shinjiro, additional, Kawaguchi, Hiroaki, additional, Furukawa, Tatsuhiko, additional, Miyazono, Kohei, additional, Ishikawa, Fuyuki, additional, Toyoshima, Hideo, additional, Kaname, Tadashi, additional, Komatsu, Masaharu, additional, Chen, Zhe-Sheng, additional, Gotanda, Takenari, additional, Tachiwada, Tokushi, additional, Sumizawa, Tomoyuki, additional, Miyadera, Kazutaka, additional, Osame, Mitsuhiro, additional, Noda, Tetsuo, additional, Yamada, Yuji, additional, and Akiyama, Shin-ichi, additional

Published
2002
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14. Expression of ABCB6 is related to resistance to 5-FU, SN-38 and vincristine.

Author

Minami K, Kamijo Y, Nishizawa Y, Tabata S, Horikuchi F, Yamamoto M, Kawahara K, Shinsato Y, Tachiwada T, Chen ZS, Tsujikawa K, Nakagawa M, Seki N, Akiyama S, Arima K, Takeda Y, and Furukawa T

Subjects
ATP-Binding Cassette Transporters metabolism, Antineoplastic Agents pharmacology, Camptothecin pharmacology, Cell Line, Tumor, Cell Proliferation drug effects, Humans, Irinotecan, KB Cells, Multidrug Resistance-Associated Proteins genetics, Multidrug Resistance-Associated Proteins metabolism, Transfection, ATP-Binding Cassette Transporters genetics, Camptothecin analogs & derivatives, Drug Resistance, Neoplasm genetics, Fluorouracil pharmacology, Gene Expression, Vincristine pharmacology
Abstract

A previously established arsenite-resistant cell line, KAS, is also resistant to a variety of anticancer drugs. In order to understand responsible molecules for the multidrug resistance phenotype of KAS cells, we examined the expressions of ATP-binding cassette (ABC) transporters and found that the ABCB6 and ABCC1/ multidrug resistance protein 1 (ABCC1/MRP1) were increased. ABCC1/MRP1 was not completely responsible for the drug resistance spectrum of KAS cells and several reports have suggested that ABCB6 is related to anticancer drug and metal resistance. We, therefore, established and examined ABCB6-expressing KB cells and ABCB6-knockdown KAS cells. ABCB6 expression enhanced resistance to 5-fluorouracil (5-FU), SN-38 and vincristine (Vcr) but not to arsenite. Conversely, down-regulation of ABCB6 in KAS cells increased the sensitivity of KAS cells to 5-FU, SN-38 and Vcr, but not to arsenite. Our findings suggest that ABCB6 is involved in 5-FU, SN-38 and Vcr resistance., (Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)

Published
2014

15. Novel oncogenic function of mesoderm development candidate 1 and its regulation by MiR-574-3p in bladder cancer cell lines.

Author

Tatarano S, Chiyomaru T, Kawakami K, Enokida H, Yoshino H, Hidaka H, Nohata N, Yamasaki T, Gotanda T, Tachiwada T, Seki N, and Nakagawa M

Subjects
Aged, Apoptosis genetics, Cell Growth Processes genetics, Cell Line, Tumor, Cell Movement genetics, Down-Regulation, Gene Expression, Humans, Male, Microarray Analysis, RNA, Messenger genetics, Transfection, Urinary Bladder Neoplasms pathology, MicroRNAs genetics, Molecular Chaperones genetics, Urinary Bladder Neoplasms genetics
Abstract

Our previous studies suggested that microRNA (miR)-574-3p is a candidate tumor suppressor microRNA (miRNA) in human bladder cancer (BC). Among 17 down-regulated miRNAs, miR-574-3p is located on chromosome 4p14 where we had identified a chromosomal loss region by array-CGH in BC cell lines. MiR-574-3p expression was down-regulated in BC cell lines. Gain-of-function analysis revealed that cell proliferation, migration and invasion were significantly inhibited in miR‑574‑3p-transfected BC cell lines. Flow cytometry analysis showed that cell apoptosis was induced in miR-574-3p transfectants. Oligo microarray analysis suggested that the mesoderm development candidate 1 (MESDC1) gene was a target gene in miR-574-3p transfectants. Luciferase assays revealed that miR‑574‑3p was directly bound to MESDC1 mRNA. MESDC1 is predicted to be a novel actin-binding protein located on chromosome 15q13. Although the gene is conserved among many species, its functional role is still unknown in both human malignancies and normal tissues. Loss-of-function studies demonstrated that cell proliferation, migration and invasion were significantly inhibited in si-MESDC1-transfected BC cell lines. Flow cytometry analysis showed that apoptosis was induced in si-MESDC1 transfectants. We are the first to demonstrate that miR-574-3p is a miRNA with tumor suppressor function and that MESDC1 (which has a potential oncogenic function in BC) may be targeted by miR-574-3p.

Published
2012
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