7 results on '"Tadeo CS"'
Search Results
2. Outcome of a Real-World Cohort of Patients Subjected to Endovascular Treatment for Acute Ischemic Stroke.
- Author
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Scopelliti G, Pero G, Macera A, Quilici L, Cervo A, Platania G, Tadeo CS, Prelle AC, Muscia F, Riggio MG, Zilioli A, Agostoni EC, Piano M, and Pantoni L
- Subjects
- Humans, Randomized Controlled Trials as Topic, Retrospective Studies, Treatment Outcome, Endovascular Procedures adverse effects, Ischemic Stroke surgery
- Abstract
Objectives: Ischemic stroke is a leading cause of death and disability worldwide. For patients with large vessel occlusion stroke, endovascular treatment is now the most effective treatment. We aimed to assess the outcome of patients undergoing endovascular treatment for large vessel occlusion stroke in a real-world setting, comparing our results with data from randomized clinical trials, and recognizing the factors associated with prognosis., Materials and Methods: We retrospectively collected data on endovascular procedures performed in one comprehensive stroke center in consecutive patients presenting with large vessel occlusion stroke from January 2017 to January 2020. Data on baseline clinical, imaging, and treatment-related characteristics were recorded. Selection of patients and treatment approach was not standardized but followed current guidelines for ischemic stroke. Functional outcome was evaluated 3 months after endovascular treatment. Clinical, imaging and treatment-related variables associated to outcome were evaluated with univariate and multivariable analyses., Results: Four hundred twelve patients were included in our study. Three-month functional independence was achieved in 50.5% of patients (50.3% in the anterior stroke and 52.1% in the posterior stroke subgroup). Successful arterial reperfusion was observed in 84.3% of patients. Age (odds ratio [OR] 0.41, 95% confidence interval [CI] 0.20-0.87, p = 0.020]), severe stroke at onset (OR 0.40, 95%CI 0.19-0.83), procedure related complications (OR 0.45, 95%CI 0.20-0.99), and good collateral circulation (OR 2.69, 95%CI 1.17-6.16) were associated with 3-month functional independence in multivariable model., Conclusions: Our real-world outcome results are in line with data from large randomized clinical trials on endovascular treatment for large vessel occlusion stroke., Competing Interests: Declaration of Competing Interest None., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2022
- Full Text
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3. Use and Prescription of Direct Oral Anticoagulants in Older and Frail Patients with Atrial Fibrillation: A Multidisciplinary Consensus Document.
- Author
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Proietti M, Camera M, Gallieni M, Gianturco L, Gidaro A, Piemontese C, Pizzetti G, Redaelli F, Scimeca B, Tadeo CS, Cesari M, Bellelli G, and Dalla Vecchia LA
- Abstract
In the last twelve years the clinical management of patients with atrial fibrillation has been revolutionised by the introduction of direct oral anticoagulants. Despite the large amount of evidence produced, some populations remain relatively poorly explored regarding the effectiveness and safety of direct oral anticoagulants, such as the oldest and/or frailest individuals. Frailty is clinical syndrome characterized by a reduction of functions and physiological reserves which results in individuals having higher vulnerability. While current evidence underlines a relationship between atrial fibrillation and frailty, particularly in determining a higher risk of adverse outcomes, data regarding effectiveness and safety of direct oral anticoagulants in frailty atrial fibrillation patients are still lacking, leaving uncertainty about how to guide prescription in this specific subgroup. On these premises, this multidisciplinary consensus document explains why it would be useful to integrate the clinical evaluation performed through comprehensive geriatric assessment to gather further elements to guide prescription of direct oral anticoagulants in such a high-risk group of patients.
- Published
- 2022
- Full Text
- View/download PDF
4. The role of clinical and neuroimaging features in the diagnosis of CADASIL.
- Author
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Bersano A, Bedini G, Markus HS, Vitali P, Colli-Tibaldi E, Taroni F, Gellera C, Baratta S, Mosca L, Carrera P, Ferrari M, Cereda C, Grieco G, Lanfranconi S, Mazucchelli F, Zarcone D, De Lodovici ML, Bono G, Boncoraglio GB, Parati EA, Calloni MV, Perrone P, Bordo BM, Motto C, Agostoni E, Pezzini A, Padovani A, Micieli G, Cavallini A, Molini G, Sasanelli F, Sessa M, Comi G, Checcarelli N, Carmerlingo M, Corato M, Marcheselli S, Fusi L, Grampa G, Uccellini D, Beretta S, Ferrarese C, Incorvaia B, Tadeo CS, Adobbati L, Silani V, Faragò G, Trobia N, Grond-Ginsbach C, and Candelise L
- Subjects
- Adult, Aged, Atrophy, CADASIL genetics, CADASIL physiopathology, Cerebral Hemorrhage diagnosis, Cerebral Hemorrhage genetics, Cerebral Hemorrhage physiopathology, Female, Humans, Ischemic Attack, Transient diagnosis, Ischemic Attack, Transient genetics, Ischemic Attack, Transient physiopathology, Magnetic Resonance Imaging, Male, Middle Aged, Prospective Studies, Stroke, Lacunar diagnosis, Stroke, Lacunar genetics, Stroke, Lacunar physiopathology, White Matter diagnostic imaging, Brain diagnostic imaging, CADASIL diagnosis, Neuroimaging, Receptor, Notch3 genetics
- Abstract
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common familial cerebral small vessel disease, caused by NOTCH3 gene mutations. The aim of our study was to identify clinical and neuroradiological features which would be useful in identifying which patients presenting with lacunar stroke and TIA are likely to have CADASIL., Methods: Patients with lacunar stroke or TIA were included in the present study. For each patient, demographic and clinical data were collected. MRI images were centrally analysed for the presence of lacunar infarcts, microbleeds, temporal lobe involvement, global atrophy and white matter hyperintensities., Results: 128 patients (mean age 56.3 ± 12.4 years) were included. A NOTCH3 mutation was found in 12.5% of them. A family history of stroke, the presence of dementia and external capsule lesions on MRI were the only features significantly associated with the diagnosis of CADASIL. Although thalamic, temporal pole gliosis and severe white matter hyperintensities were less specific for CADASIL diagnosis, the combination of a number of these factors together with familial history for stroke result in a higher positive predictive value and specificity., Conclusions: A careful familial history collection and neuroradiological assessment can identify patients in whom NOTCH3 genetic testing has a higher yield.
- Published
- 2018
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5. Clinical Pregenetic Screening for Stroke Monogenic Diseases: Results From Lombardia GENS Registry.
- Author
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Bersano A, Markus HS, Quaglini S, Arbustini E, Lanfranconi S, Micieli G, Boncoraglio GB, Taroni F, Gellera C, Baratta S, Penco S, Mosca L, Grasso M, Carrera P, Ferrari M, Cereda C, Grieco G, Corti S, Ronchi D, Bassi MT, Obici L, Parati EA, Pezzini A, De Lodovici ML, Verrengia EP, Bono G, Mazucchelli F, Zarcone D, Calloni MV, Perrone P, Bordo BM, Colombo A, Padovani A, Cavallini A, Beretta S, Ferrarese C, Motto C, Agostoni E, Molini G, Sasanelli F, Corato M, Marcheselli S, Sessa M, Comi G, Checcarelli N, Guidotti M, Uccellini D, Capitani E, Tancredi L, Arnaboldi M, Incorvaia B, Tadeo CS, Fusi L, Grampa G, Merlini G, Trobia N, Comi GP, Braga M, Vitali P, Baron P, Grond-Ginsbach C, and Candelise L
- Subjects
- Adult, Aged, CADASIL complications, Cerebral Amyloid Angiopathy, Familial complications, DNA Mutational Analysis, Fabry Disease complications, Female, Humans, MELAS Syndrome complications, Male, Marfan Syndrome complications, Middle Aged, Mutation, Registries, Stroke etiology, CADASIL genetics, Cerebral Amyloid Angiopathy, Familial genetics, Fabry Disease genetics, Genetic Testing, MELAS Syndrome genetics, Marfan Syndrome genetics, Stroke genetics
- Abstract
Background and Purpose: Lombardia GENS is a multicentre prospective study aimed at diagnosing 5 single-gene disorders associated with stroke (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, Fabry disease, MELAS [mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes], hereditary cerebral amyloid angiopathy, and Marfan syndrome) by applying diagnostic algorithms specific for each clinically suspected disease, Methods: We enrolled a consecutive series of patients with ischemic or hemorrhagic stroke or transient ischemic attack admitted in stroke units in the Lombardia region participating in the project. Patients were defined as probable when presenting with stroke or transient ischemic attack of unknown etiopathogenic causes, or in the presence of <3 conventional vascular risk factors or young age at onset, or positive familial history or of specific clinical features. Patients fulfilling diagnostic algorithms specific for each monogenic disease (suspected) were referred for genetic analysis., Results: In 209 patients (57.4±14.7 years), the application of the disease-specific algorithm identified 227 patients with possible monogenic disease. Genetic testing identified pathogenic mutations in 7% of these cases. Familial history of stroke was the only significant specific feature that distinguished mutated patients from nonmutated ones. The presence of cerebrovascular risk factors did not exclude a genetic disease., Conclusions: In patients prescreened using a clinical algorithm for monogenic disorders, we identified monogenic causes of events in 7% of patients in comparison to the 1% to 5% prevalence reported in previous series., (© 2016 American Heart Association, Inc.)
- Published
- 2016
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6. JC Virus Replication at the First Symptoms of Multiple Sclerosis: A Case Report.
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Delbue S, Tadeo CS, Elia F, and Ferrante P
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- Blood virology, Cerebrospinal Fluid virology, Female, Humans, Polyomavirus Infections virology, Tumor Virus Infections virology, Urine virology, JC Virus isolation & purification, Multiple Sclerosis etiology, Polyomavirus Infections complications, Tumor Virus Infections complications
- Abstract
Multiple sclerosis (MS) is an autoimmune, demyelinating disorder of unknown etiology, in which viruses have been suggested as etiological/triggering agents. The attention to the association between viruses and MS has been rekindled by the development of progressive multifocal leukoencephalopathy in natalizumab-treated MS patients. Here we report the case of a woman with JC virus (JCV) replication in the cerebrospinal fluid, blood and urine collected at the first symptoms of MS and during several follow-up visits. This observation shows that JCV can be associated with MS without a relation with natalizumab treatment, although the triggering role of JCV in some cases of MS will require further studies., (© 2015 S. Karger AG, Basel.)
- Published
- 2015
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7. fMRI changes in the brain associated with the carotid compression test.
- Author
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Righini A, Orsi M, Tadeo CS, Ceccarelli G, Locatelli M, Lucchetti F, Leonardi M, and Cabrini GP
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- Adult, Carotid Artery, Common diagnostic imaging, Cerebrovascular Circulation, Circle of Willis anatomy & histology, Female, Humans, Magnetic Resonance Angiography, Magnetic Resonance Imaging instrumentation, Male, Pressure, Reference Values, Time Factors, Ultrasonography, Doppler, Transcranial instrumentation, Ultrasonography, Doppler, Transcranial methods, Brain anatomy & histology, Carotid Artery, Common physiology, Magnetic Resonance Imaging methods
- Abstract
Purpose: The purpose of our investigation was to study in normal volunteers the response to a unilateral common carotid (CC) compression test using dynamic MRI sensitive to variations in blood magnetic susceptibility., Method: Nine volunteers, positioned in a 1.5 T MR scanner, performed a unilateral 40 to 45 s CC self-compression during the acquisition of single slice axial T2*-weighted FLASH images., Results: In three subjects, the signal showed a significant 2% drop from baseline in the ipsilateral frontal temporal cortex during the compression. In another three subjects, a significant 1.5-2% signal decrease was observed in both hemispheres. In two subjects whose MR angiography showed abnormalities of the circle of Willis, the bilateral signal drop was more remarkable (3%). In one volunteer, the signal did not change., Conclusion: Increased deoxyhemoglobin within the brain microcirculation is the probable explanation for the signal drop. This method could be further tested in view of the widespread use of open interventional MR units.
- Published
- 1998
- Full Text
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