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29. The Impact of Preprocedural Blood Pressure on Outcome After M‐TEER: The Paradox or Something Else?

Author

Tadic, Marijana, Schneider, Leonhard, Nita, Nicoleta, Felbel, Dominik, Paukovitsch, Michael, Gröger, Mathias, Keßler, Mirjam, and Rottbauer, Wolfang

Subjects
SYSTOLIC blood pressure, MITRAL valve, MITRAL valve insufficiency, BLOOD pressure, HOSPITAL admission & discharge
Abstract

Objective: The aim of this study was to investigate the influence of systolic blood pressure (SBP) values on admission on the outcome of mitral transcatheter edge‐to‐edge repair (M‐TEER). Methodology: We included all patients who underwent interventional MV repair in our institution between January 2010 and October 2020. All data are obtained from the MiTra ULM registry. Based on SBP values measured on admission, all patients were divided into four groups: < 120, 120−129, 130−139, and ≥ 140 mmHg. Results: Eight hundred and fifty‐eight patients were included in this study. There were no major differences in demographic and clinical characteristics between the four observed groups. The patients with SBP on admission ≥ 140 mmHg had the lowest prevalence of functional MR and the highest LVEF. Higher SBP at admission (HR 0.74, 95% CI: 0.63−0.87) and preprocedural LVEF values (HR 0.99, 95% CI: 0.97−0.99) were predictors of lower 1‐year mortality but did not impact 1‐year hospitalization rate or MACE in the whole study population. When patients were separated into two groups according to the mechanisms of MR (functional and structural), the results showed that higher SBP on admission and better preprocedural LVEF were associated with significantly lower 1‐year CV mortality in both groups of patients, with functional and structural MR. Higher SBP at admission was also associated with lower 1‐year CV mortality (HR 0.73, 95% CI: 0.55−0.96) in patients with preserved ejection fraction (LVEF > 50%), but not with 1‐year rehospitalization and MACE. Conclusion: Higher SBP on admission (> 140 mmHg) is an independent predictor of a better 1‐year outcome in patients treated with M‐TEER. The effect of higher SBP on outcome after M‐TEER should be further investigated. [ABSTRACT FROM AUTHOR]

Published
2024
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30. The Predictive Value of Global Longitudinal and Circumferential Strains in Hypertensive Patients: 10-Year Follow-Up.

Author

Tadic, Marijana, Filipovic, Tamara, Suzic, Jelena, Majstorovic, Anka, Pencic, Biljana, Vukomanovic, Vladan, Cuspidi, Cesare, and Celic, Vera

Subjects
*GLOBAL longitudinal strain, *LEFT ventricular hypertrophy, *SYSTOLIC blood pressure, *HYPERTENSION, *SPECKLE interferometry
Abstract

Background: The aim of the current study was to investigate the predictive value of a multidirectional LV strain on adverse outcomes in a large population of uncomplicated hypertensive patients who were followed for a mean period of 10 years. Methods: This retrospective study included 591 recently diagnosed hypertensive patients who underwent clinically indicated echocardiography between January 2010 and December 2014 and were followed for a mean period of 10 years. Global longitudinal, circumferential and radial strains (GLS, GCS and GRS) were measured by 2D speckle tracking imaging. The primary outcome was a MACE occurrence defined by all-cause mortality, cardiovascular mortality, myocardial infarction, coronary artery by-pass, coronary stent implantation, stroke, development of heart failure and the occurrence of atrial fibrillation during follow-up. Results: Our results showed that GLS, GCS and GRS were significantly lower in patients who experienced MACE. Age, male gender, systolic blood pressure, left ventricular hypertrophy (LVH) and left atrial enlargement (LAE) were associated with MACE occurrence. Reduced GLS [OR 1.15; 95%CI: 1.01–1.30] and reduced GCS [OR 1.1; 95%CI: 1.02–1.22] were related with MACE independently of clinical characteristics, LV systolic and diastolic function, as well as LVH. Reduced GRS was not independently associated with adverse outcomes. Conclusions: Reduced GLS and GCS were independently associated with adverse outcomes during 10-year follow-up in patients who were recently diagnosed and uncomplicated hypertensive patients at the baseline. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Long-Term Mortality after Transcatheter Edge-to-Edge Mitral Valve Repair Significantly Decreased over the Last Decade: Comparison between Initial and Current Experience from the MiTra Ulm Registry

Author

Nita, Nicoleta, primary, Tadic, Marijana, additional, Mörike, Johannes, additional, Paukovitsch, Michael, additional, Felbel, Dominik, additional, Keßler, Mirjam, additional, Gröger, Matthias, additional, Schneider, Leonhard-Moritz, additional, and Rottbauer, Wolfgang, additional

Published
2024
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44. Myocardial Mechanics in Acromegaly: A Meta-Analysis of Echocardiographic Studies

Author

Gherbesi, E, Faggiano, A, Sala, C, Carugo, S, Grassi, G, Cuspidi, C, Tadic, M, Gherbesi, Elisa, Faggiano, Andrea, Sala, Carla, Carugo, Stefano, Grassi, Guido, Cuspidi, Cesare, Tadic, Marijana, Gherbesi, E, Faggiano, A, Sala, C, Carugo, S, Grassi, G, Cuspidi, C, Tadic, M, Gherbesi, Elisa, Faggiano, Andrea, Sala, Carla, Carugo, Stefano, Grassi, Guido, Cuspidi, Cesare, and Tadic, Marijana

Abstract

Introduction: Evidence on myocardial deformation, detected by speckle tracking echocardiography (STE), in patients with acromegaly is scanty. Aim: The aim of the present meta-analysis was to provide an updated information on left ventricular (LV) systolic function assessed by global longitudinal strain (GLS) in patients with acromegaly and preserved LVEF. Methods: Following the PRISMA guidelines, systematic searches were conducted across bibliographic databases (Pub-Med, OVID, EMBASE and Cochrane library) to identify eligible studies from inception up to June 30-2024. Clinical studies published in English reporting data on LV mechanics in patients with acromegaly and controls were included. The statistical difference of the echocardiographic variables of interest between groups such as LVEF and global longitudinal strain (GLS) was calculated by standardized mean difference (SMD) with 95% confidence interval (CI) by using random-effects models. Results: Seven studies including 288 patients with acromegaly and 294 healthy individuals were considered for the analysis. Pooled average LVEF values were 64.6 ± 1.5% in the healthy control group and 64.0 ± 1.3% in the acromegaly group (SMD: - 0.21 ± 0.22, CI -0.62/0.22, p = 0.34); the corresponding values of GLS were - 19.1.1 ± 1.2% and - 17.5 ± 1.2% (SMD: -0.52 ± 0.27, CI - 1.05/0.01, p = 0.05). No difference was found between the two groups for both global circumferential strain (GCS) and global radial strain (GRS). Conclusions: Our findings suggest that patients with acromegaly in which LVEF is completely comparable to healthy controls show an impairment in GLS of borderline statistical significance. Whether GLS assessment can actually unmask early alterations of systolic function in patients with acromegaly better than LVEF will need to be investigated by future studies.

Published
2024

45. Myocardial mechanics in anorexia nervosa: a systematic review and meta-analysis of speckle tracking echocardiographic studies

Author

Gherbesi, E, Faggiano, A, Sala, C, Carugo, S, Grassi, G, Cuspidi, C, Tadic, M, Gherbesi, Elisa, Faggiano, Andrea, Sala, Carla, Carugo, Stefano, Grassi, Guido, Cuspidi, Cesare, Tadic, Marijana, Gherbesi, E, Faggiano, A, Sala, C, Carugo, S, Grassi, G, Cuspidi, C, Tadic, M, Gherbesi, Elisa, Faggiano, Andrea, Sala, Carla, Carugo, Stefano, Grassi, Guido, Cuspidi, Cesare, and Tadic, Marijana

Abstract

Background: Clinical complications of anorexia nervosa (AN) include cardiac structural and functional alterations. Available evidence on impaired myocardial deformation in AN patients without overt systolic dysfunction as assessed by left ventricular ejection fraction (LVEF) is scanty and based on a few studies. The aim of the present meta-analysis was to provide comprehensive and updated information on this issue. Methods: Following the PRISMA guidelines, systematic searches were conducted across bibliographic databases (Pub-Med, OVID, EMBASE and Cochrane library) to identify eligible studies from inception up to 31 January 2024. Searches were limited to clinical investigations published in English reporting data on left ventricular (LV) mechanics (i.e. global longitudinal strain) in patients with anorexia and controls. The statistical difference of the echocardiographic variables of interest between groups such as LVEF and global longitudinal strain (GLS) was calculated by standardized mean difference (SMD) with 95% confidence interval (CI) by using random-effects models. Results: Five studies including 171 AN and 147 healthy normal-weight individuals were considered for the analysis. Pooled average LVEF values were 63.2 ± 0.4% in the healthy control group and 64.6 ± 1.0% in the AN group (SMD -0.08 ± 0.11, CI: -0.15/0.30, P = 0.51); the corresponding values of GLS were -20.1 ± 0.9% and -20.2 ± 0.9% (SMD 0.07 ± 0.3, CI: -0.46/0.60, P = 0.80). Unlike GLS, apical strain (data from three studies) was higher in AN than in controls (-23.1 ± 1.8 vs. -21.3 ± 1.8; SMD: -0.42 ± 0.17, CI: -0.08/-0.76, P = 0.01). Conclusions: The results of the present meta-analysis do not support the view that myocardial deformation as assessed by GLS is impaired in patients with AN and preserved LVEF. The role of STE in detecting subclinical cardiac damage in this clinical condition deserves to be evaluated in future studies including regional LV strain.

Published
2024

50. Heart and Prehypertension

Author

Cuspidi, Cesare, Tadic, Marijana, Grassi, Guido, Mancia, Giuseppe, Series Editor, Rosei, Enrico Agabiti, Series Editor, Zimlichman, Reuven, editor, and Julius, Stevo, editor

Published
2019
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