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Human RECQL5 is a member of the RecQ helicase family, which maintains genome stability via participation in many DNA metabolic processes, including DNA repair. Human cells lacking RECQL5 display chromosomal instability. We find that cells depleted of RECQL

This article discusses a case of IgA vasculitis in a patient with heart involvement. The patient had a history of heavy smoking and experienced dyspnea when lying down. The patient underwent surgery, including coronary artery bypass surgery and mitral valvuloplasty, to treat heart failure. The article also mentions that the patient had microscopic hematuria during the acute phase of IgA vasculitis, but exhaustive serologic testing did not identify any obvious triggers for the condition. The article emphasizes the importance of identifying triggers for adult IgA vasculitis. [Extracted from the article]

Complement component 3 (C3) and IgA depositions were observed in the vessel walls (Figure 1d and e), confirming IgA vasculitis. Therefore, clinicians should consider IgA vasculitis even in adults if they notice palpable purpura and abdominal pain. Also has a high recurrence rate of 32%, despite typically having a good prognosis.[2] If is generalized as a childhood disease, it may be overlooked during differential diagnosis. [Extracted from the article]

This work reports growth of α-(AlxGa1-x)2O3 single crystals with high incorporation of Al by a Mist Chemical Vapor Deposition two-chamber system, which was rationally designed to avoid side-reactions between different precursors during solution preparation for multi-component thin film growth. Multiple acceleration voltages were used in Energy Dispersive X-ray measurements to reliably obtain the Al composition x of the films. As a result, Vegard's law for lattice constants was verified and found to be valid in the α-(AlxGa1-x)2O3 system. However, Vegard's law for optical bandgaps, derived from different models, required an additional term to account for the bowing effect. At x = 0.71, the gaps were 7.74, 7.03, 7.26, and 7.34 eV as derived from the Tauc plots for the direct bandgap, indirect bandgap, Tauc-Lorentz model, and O'Leary-Johnson-Lim model, respectively. The two-chamber system provides reliable and effective control of the Al content in α-(AlxGa1-x)2O3 alloys and heterostructures. [ABSTRACT FROM AUTHOR]

The electrocardiogram performed on hospitalization showed a new complete right bundle branch block, first-degree atrioventricular block, left-axis deviation and abnormal Q wave in leads II, III and aVF. The patient's electrocardiograms obtained on regular health check-ups at 8 and 4 years prior to hospitalization were normal, except for voltage reduction in all leads, which suggests cardiac amyloidosis (Figure 1a).[1] This finding is easily missed when electrocardiograms are not compared. (b) Transthoracic echocardiography showed systolic and diastolic left ventricular dysfunction with diffuse left ventricular hypertrophy and mild pericardial effusion. [Extracted from the article]

After kidney function recovery, the patient's uric acid (UA) level was as low as it was at hospitalization, but the fractional excretion of UA remained high. Dysfunction of these transporters causes RHUC, and nephrolithiasis or EIAKI are known complications of RHUC; however, the exact frequencies of these complications remain unknown. [Extracted from the article]