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2. Chronological alterations in de novo malignancies after living‐donor liver transplantation: A cohort study of 1781 recipients using annual comparisons of standardized incidence ratios

Author

Tajima, Tetsuya, primary, Hata, Koichiro, additional, Tanaka, Kosuke, additional, Iyama, Naomi, additional, Kusakabe, Jiro, additional, Kageyama, Shoichi, additional, Ogawa, Eri, additional, Okamoto, Tatsuya, additional, Haga, Hironori, additional, Uemoto, Shinji, additional, and Hatano, Etsuro, additional

Published
2024
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3. Epstein–Barr virus‐associated post‐transplant lymphoproliferative disorders in pediatric transplantation: A prospective multicenter study in the United States

Author

Tajima, Tetsuya, primary, Martinez, Olivia M., additional, Bernstein, Daniel, additional, Boyd, Scott D., additional, Gratzinger, Dita, additional, Lum, Grant, additional, Sasaki, Kazunari, additional, Tan, Brent, additional, Twist, Clare J., additional, Weinberg, Kenneth, additional, Armstrong, Brian, additional, Desai, Dev M., additional, Mazariegos, George V., additional, Chin, Clifford, additional, Fishbein, Thomas M., additional, Tekin, Akin, additional, Venick, Robert S., additional, Krams, Sheri M., additional, and Esquivel, Carlos O., additional

Published
2024
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7. Cost‐effectiveness analysis of adult living‐donor liver transplantation in Japan.

Author

Tajima, Tetsuya, Shin, Jung‐Ho, Kunisawa, Susumu, Sasaki, Noriko, Hata, Koichiro, Fushimi, Kiyohide, Hatano, Etsuro, and Imanaka, Yuichi

Subjects
*LIVER transplantation, *JAPANESE yen, *COST effectiveness, *PROPENSITY score matching, *U.S. dollar
Abstract

Aim: Living‐donor liver transplantation (LDLT) is a highly effective life‐saving procedure; however, it requires substantial medical resources, and the cost‐effectiveness of LDLT versus conservative management (CM) for adult patients with end‐stage liver disease (ESLD) remains unclear in Japan. Methods: We performed a cost‐effectiveness analysis using the Diagnostic Procedure Combination (DPC) data from the nationwide database of the DPC research group. We selected adult patients (18 years or older) who were admitted or discharged between 2010 and 2021 with a diagnosis of ESLD with Child–Pugh class C or B. A decision tree and Markov model were constructed, and all event probabilities were computed in 3‐month cycles over a 10‐year period. The willingness‐to‐pay per quality‐adjusted life‐year (QALY) was set at 5 million Japanese yen (JPY) (49,801 US dollars [USD]) from the perspective of the public health‐care payer. Results: After propensity score matching, we identified 1297 and 111,849 patients in the LDLT and CM groups, respectively. The incremental cost‐effectiveness ratio for LDLT versus CM for Child–Pugh classes C and B was 2.08 million JPY/QALY (20,708 USD/QALY) and 5.24 million JPY/QALY (52,153 USD/QALY), respectively. The cost‐effectiveness acceptability curves showed the probabilities of being below the willingness‐to‐pay of 49,801 USD/QALY as 95.4% in class C and 48.5% in class B. Tornado diagrams revealed all variables in class C were below 49,801 USD/QALY while their ranges included or exceeded 49,801 USD/QALY in class B. Conclusions: Living‐donor liver transplantation for adult patients with Child–Pugh class C was cost‐effective compared with CM, whereas LDLT versus CM for class B patients was not cost‐effective in Japan. [ABSTRACT FROM AUTHOR]

Published
2024
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11. 311.2: Risk factors for Epstein-Barr virus DNAemia in pediatric transplantation: A multicenter study in the United States

Author

Tajima, Tetsuya, primary, Bernstein, Daniel, additional, Boyd, Scott D, additional, Gratzinger, Dita, additional, Lum, Grant, additional, Sasaki, Kazunari, additional, Tan, Brent, additional, Weinberg, Kenneth, additional, Armstrong, Brian, additional, Brown, Meredith, additional, Chin, Clifford, additional, Desai, Dev, additional, Fishbein, Thomas M, additional, Mazariegos, George, additional, Robien, Mark A, additional, Tekin, Akin, additional, Twist, Clare J, additional, Venick, Robert S, additional, Krams, Sheri M, additional, Martinez, Olivia M, additional, and Esquivel, Carlos O, additional

Published
2023
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13. Anti-complement 5 antibody ameliorates antibody-mediated rejection after liver transplantation in rats

Author

Tajima, Tetsuya, primary, Hata, Koichiro, additional, Kusakabe, Jiro, additional, Miyauchi, Hidetaka, additional, Badshah, Joshua Sam, additional, Kageyama, Shoichi, additional, Zhao, Xiangdong, additional, Kim, Sung-Kwon, additional, Tsuruyama, Tatsuaki, additional, Kirchner, Varvara A., additional, Watanabe, Takeshi, additional, Uemoto, Shinji, additional, and Hatano, Etsuro, additional

Published
2023
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14. The impact of colonic allograft inclusion on intestinal transplantation outcomes: Results from UNOS/OPTN database analysis.

Author

Matsushima, Hajime, Sasaki, Kazunari, Nair, Amit, Tajima, Tetsuya, Soyama, Akihiko, Eguchi, Susumu, Hashimoto, Koji, and Fujiki, Masato

Subjects
TREATMENT effectiveness, DATABASES, SURVIVAL analysis (Biometry), PROPORTIONAL hazards models, HOMOGRAFTS
Abstract

Background: Outcomes of intestinal transplantation with colon allograft (ICTx) remain controversial. We aimed to assess the outcomes of ICTx in comparison to intestinal transplantation without colon (ITx) using the UNOS/OPTN registry database. Methods: We retrospectively reviewed 2612 patients who received primary intestinal transplants from 1998 to 2020. The rates of acute rejection (AR) within 6 months after transplant were compared between ICTx and ITx. Risk factors of 6‐month AR were examined using logistic regression model by era. Furthermore, conditional graft survival was analyzed to determine long‐term outcomes of ICTx. Results: Of 2612 recipients, 506 (19.4%) received ICTx. Graft and patient survival in ICTx recipients were comparable to those in ITx recipients. White ICTx recipients had a higher incidence of AR within 6 months compared to ITx during the entire study period (p =.002), colonic inclusion did not increase the risk of 6‐month AR in the past decade. ICTx recipients who experienced 6‐month AR had worse graft and patient survival compared to those who did not (p <.001 and p =.004, respectively). Among patients who did not develop 6‐month AR, Cox proportional hazard model analysis revealed that colonic inclusion was independently associated with improved conditional graft survival. Conclusions: In the recent transplant era, colonic inclusion is no longer associated with a heightened risk of 6‐month AR and may provide better long‐term survival compared to ITx when AR is absent. Risk adjustment for rejection and proper immunosuppressive therapy are crucial to maximize the benefits of colonic inclusion. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Risk factors for antibody-mediated rejection in ABO blood-type incompatible and donor-specific antibody-positive liver transplantation

Author

Tajima, Tetsuya, primary, Hata, Koichiro, additional, Haga, Hironori, additional, Kusakabe, Jiro, additional, Kageyama, Shoichi, additional, Yurugi, Kimiko, additional, Hishida, Rie, additional, Zhao, Xiangdong, additional, Nishikori, Momoko, additional, Nagao, Miki, additional, Takaori-Kondo, Akifumi, additional, Uemoto, Shinji, additional, and Hatano, Etsuro, additional

Published
2023
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19. Major Causes of Death among Older Adults after the Great East Japan Earthquake : A Retrospective Study

Author

Fujimaki, Takako, Ohno, Yuko, Tsutsui, Anna, Inoue, Yuta, Zha, Ling, Fujii, Makoto, Tajima, Tetsuya, Hattori, Satoshi, Sobue, Tomotaka, Fujimaki, Takako, Ohno, Yuko, Tsutsui, Anna, Inoue, Yuta, Zha, Ling, Fujii, Makoto, Tajima, Tetsuya, Hattori, Satoshi, and Sobue, Tomotaka

Abstract

This retrospective study investigated the 3-year impact of the Great East Japan Earthquake (GEJE) of 2011 on deaths due to neoplasm, heart disease, stroke, pneumonia, and senility among older adults in the primarily affected prefectures compared with other prefectures, previous investigations having been more limited as regards mortality causes and geographic areas. Using death certificates issued between 2006 and 2015 (n = 7,383,253), mortality rates (MRs) and risk ratios (RRs) were calculated using a linear mixed model with the log-transformed MR as the response variable. The model included interactions between the area category and each year of death from 2010 to 2013. The RRs in the interaction significantly increased to 1.13, 1.17, and 1.28 for deaths due to stroke, pneumonia, and senility, respectively, in Miyagi Prefecture in 2011, but did not significantly increase for any of the other areas affected by the GEJE. Moreover, increased RRs were not reported for any of the other years. The risk of death increased in 2011; however, this was only significant for single-year impact. In 2013, decreased RRs of pneumonia in the Miyagi and Iwate prefectures and of senility in Fukushima Prefecture were observed. Overall, we did not find evidence of strong associations between the GEJE and mortality.

Published
2023

24. The impact of human leukocyte antigen mismatch on recipient outcomes in living‐donor liver transplantation

Author

Tajima, Tetsuya, primary, Hata, Koichiro, additional, Kusakabe, Jiro, additional, Miyauchi, Hidetaka, additional, Yurugi, Kimiko, additional, Hishida, Rie, additional, Ogawa, Eri, additional, Okamoto, Tatsuya, additional, Sonoda, Mari, additional, Kageyama, Shoichi, additional, Zhao, Xiangdong, additional, Ito, Takashi, additional, Seo, Satoru, additional, Okajima, Hideaki, additional, Nagao, Miki, additional, Haga, Hironori, additional, Uemoto, Shinji, additional, and Hatano, Etsuro, additional

Published
2022
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25. Survey Regarding Gastrointestinal Stoma Construction and Closure in Japan

Author

Ando, Yoshiko, primary, Takahashi, Arata, additional, Fujii, Makoto, additional, Hasegawa, Hiroshi, additional, Kimura, Toshimoto, additional, Yamamoto, Hiroyuki, additional, Tajima, Tetsuya, additional, Nishiguchi, Yukio, additional, Kakeji, Yoshihiro, additional, Miyata, Hiroaki, additional, and Kitagawa, Yuko, additional

Published
2021
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27. Post‐transplant Lymphoproliferative Disorders After Liver Transplantation: A Retrospective Cohort Study Including 1954 Transplants

Author

Tajima, Tetsuya, primary, Hata, Koichiro, additional, Haga, Hironori, additional, Nishikori, Momoko, additional, Umeda, Katsutsugu, additional, Kusakabe, Jiro, additional, Miyauchi, Hidetaka, additional, Okamoto, Tatsuya, additional, Ogawa, Eri, additional, Sonoda, Mari, additional, Hiramatsu, Hidefumi, additional, Fujimoto, Masakazu, additional, Okajima, Hideaki, additional, Takita, Junko, additional, Takaori‐Kondo, Akifumi, additional, and Uemoto, Shinji, additional

Published
2021
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28. Risk factors for non-cancer death after surgery in patients with stage I non-small-cell lung cancer

Author

Kanzaki, Ryu, primary, Nagoya, Akihiro, additional, Kanou, Takashi, additional, Ose, Naoko, additional, Funaki, Soichiro, additional, Minami, Masato, additional, Okamoto, Yuna, additional, Tabuchi, Hiroto, additional, Hoshino, Tomoko, additional, Tajima, Tetsuya, additional, Fujii, Makoto, additional, Ohno, Yuko, additional, and Shintani, Yasushi, additional

Published
2021
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30. Survey Regarding Gastrointestinal Stoma Construction and Closure in Japan.

Author

Ando, Yoshiko, Takahashi, Arata, Fujii, Makoto, Hasegawa, Hiroshi, Kimura, Toshimoto, Yamamoto, Hiroyuki, Tajima, Tetsuya, Nishiguchi, Yukio, Kakeji, Yoshihiro, Miyata, Hiroaki, and Kitagawa, Yuko

Abstract

Background and Aim: In Japan, the actual number of stoma constructions and stoma closures is not known. The aim of this study was to conduct a survey to determine the number of gastrointestinal stoma constructions and closures in Japan. Methods: Enrolled participants comprised patients undergoing selected gastrointestinal surgeries who were recorded in the National Clinical Database. This database uses the "Common Items for Gastrointestinal Surgeons." These procedures were formulated by the Japanese Society of Gastroenterological Surgery during 2013–2018. Results: According to the National Clinical Database, a total of 154,323 gastrointestinal stomas were constructed between January 1, 2013 and December 31, 2018. By procedure, there were 78,723 cases of stoma construction, 39,653 of abdominoperineal resection, 2470 total pelvic exenteration procedures, and 33,572 Hartmann's procedures. The ratio of stoma closures to stoma constructions increased annually in patients under 70 y of age but not in older patients. Approximately 35% of total colectomies, 60% of proctocolectomies, and 20% of low anterior resections were accompanied by stoma construction. The number of patients with rectal cancer who underwent colostomy increased gradually during the study period and the number who underwent stoma construction increased among older patients. Conclusion: The number of cases of gastrointestinal stoma construction has increased gradually in Japan, and the proportion of older patients is increasing each year. The purposes and surgical techniques for stoma construction are diverse and are expected to increase in Japan, a super‐aged society. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Association of crossing capillaries in the finger nailfold with diabetic retinopathy in type 2 diabetes mellitus.

Author

Shikama, Maiko, Sonoda, Nao, Morimoto, Akiko, Suga, Sayaka, Tajima, Tetsuya, Kozawa, Junji, Maeda, Norikazu, Otsuki, Michio, Matsuoka, Taka‐Aki, Shimomura, Iichiro, and Ohno, Yuko

Subjects
TYPE 2 diabetes, DIABETIC retinopathy, FINGERS, CAPILLARIES, GLYCOSYLATED hemoglobin
Abstract

Aims/Introduction: Crossing capillaries in the finger nailfold might potentially be a novel diabetic retinopathy (DR) biomarker that could be assessed non‐invasively in the clinical setting. However, the association between crossing capillaries and DR is controversial. This study aimed to investigate the association between the percentage of crossing capillaries in the finger nailfold and DR in patients with type 2 diabetes mellitus. Materials and Methods: This cross‐sectional study enrolled 108 type 2 diabetes mellitus patients (aged 40–75 years) who visited the outpatient diabetic clinic at Osaka University Hospital, Osaka, Japan, between May and October 2019. Capillary morphology was assessed using nailfold capillaroscopy based on the simple capillaroscopic definitions of the European League Against Rheumatism Study Group. Details of DR and other laboratory data were obtained from medical records. The association between the tertile of the percentage of the crossing capillary and DR was analyzed using multivariable logistic regression. Results: After adjusting for age, sex, diabetes duration, glycated hemoglobin, systolic blood pressure, body mass index, and use of renin–angiotensin system inhibitor and antihyperlipidemic medication, the percentage of crossing capillaries was significantly associated with DR (multivariable‐adjusted odds ratios for increasing tertiles of the percentage of crossing capillary: 1 [reference], 2.05 [95% confidence interval 0.53–7.94], and 4.33 [95% confidence interval 1.16–16.21]; P‐trend = 0.028). Conclusions: A higher percentage of crossing capillaries in the nailfold was associated with a higher risk of DR, independent of traditional risk and inhibiting factors, in patients with type 2 diabetes mellitus. [ABSTRACT FROM AUTHOR]

Published
2021
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33. Validation of Eurolung risk models in a Japanese population: a retrospective single-centre analysis of 612 cases

Author

Nagoya, Akihiro, primary, Kanzaki, Ryu, additional, Kanou, Takashi, additional, Ose, Naoko, additional, Funaki, Soichiro, additional, Minami, Masato, additional, Shintani, Yasushi, additional, Tsutsui, Anna, additional, Suga, Sayaka, additional, Tajima, Tetsuya, additional, Ohno, Yuko, additional, and Okumura, Meinoshin, additional

Published
2019
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35. Hydrogen Flush After Cold Storage as a New End‐Ischemic Ex Vivo Treatment for Liver Grafts Against Ischemia/Reperfusion Injury

Author

Tamaki, Ichiro, primary, Hata, Koichiro, additional, Okamura, Yusuke, additional, Nigmet, Yermek, additional, Hirao, Hirofumi, additional, Kubota, Toyonari, additional, Inamoto, Osamu, additional, Kusakabe, Jiro, additional, Goto, Toru, additional, Tajima, Tetsuya, additional, Yoshikawa, Junichi, additional, Tanaka, Hirokazu, additional, Tsuruyama, Tatsuaki, additional, Tolba, Rene H., additional, and Uemoto, Shinji, additional

Published
2018
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42. Younger Age is an Independent Factor for Graft Weight Overestimation: Analysis of the Clinical Impact on Recipient Outcomes in 340 Japanese Living Liver Donors.

Author

Kitajima, Toshihiro, Kaido, Toshimi, Tajima, Tetsuya, Uemura, Tadahiro, Fujimoto, Yasuhiro, Schenk, Andrea, and Uemoto, Shinji

Subjects
ORGAN donors, LIVER transplantation, WEIGHT measurement, MULTIVARIATE analysis, PREOPERATIVE period
Abstract

Background: Accurate preoperative estimation of graft weight is essential for improving outcomes in living donor liver transplantation. Methods: This retrospective study sought to identify factors associated with graft weight overestimation. From April 2006 to August 2015, 340 living donors were assigned to no-overestimate ( n = 284) or overestimate ( n = 56) groups. We defined graft weight overestimation as a discrepancy ≥15% between estimated graft volume and actual graft weight. Donor data were compared, and associated factors for graft weight overestimation were analyzed. Recipient outcomes were compared between the groups according to identified factors. Results: Donors were significantly younger in the overestimate group than in the no-overestimate group (35.0 vs. 46.0 years; p < 0.001). Multivariate analysis identified donor age <45 years as an independent risk factor for graft weight overestimation (odds ratio 2.068; 95% confidence interval 1.114-3.839; p = 0.021). Among recipients with donors <45 years ( n = 168), incidence of small-for-size dysfunction (SFSD) was significantly higher in the overestimate group than in the no-overestimate group (7/37 patients vs. 7/131 patients; p = 0.016); no significant difference was observed among recipients with donors ≥45 years ( n = 172). First-year mortality was lower in SFSD recipients with donors <45 years (14.3 vs. 60.9%, p = 0.007). Among recipients with younger donors, graft survival was not significantly different between overestimate and no-overestimate groups. Conclusions: Younger donor age was an independent risk factor for graft weight overestimation leading to SFSD in recipients, but did not impair graft survival. [ABSTRACT FROM AUTHOR]

Published
2018
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