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5. A Genetic Platform for Functionally Profiling Odorant Receptors Ex Vivo Using Olfactory Cilia

Author

Takabatake Y, Benjamin-Hong S, Paul Feinstein, Omura M, and Charlotte D’Hulst

Subjects
Odor, Cilium, Heterologous, Sensory system, Olfaction, Signal transduction, Biology, Receptor, Ex vivo, Cell biology
Abstract

The molecular basis for odor perception in humans remains a black box as odorant receptors (ORs) are notoriously difficult to study outside of their native environment. Efforts toward OR expression and functional profiling in heterologous systems have been met with limited success due to poor efficiency of cell surface expression and consequently reduced G-protein signal amplification. We previously reported a genetic strategy in mice to increase the number of sensory neurons expressing specific ORs, which transforms the 10 million neurons of the mouse nose into a bioreactor producing large quantities of fully functional OR protein. We now describe the isolation of cilia from these bioreactors for two human ORs. Cilia are known to contain all components of the olfactory signal transduction machinery and can be placed into an ex vivo well-plate assay to rapidly measure robust, reproducible odor-specific responses. Our OR1A1 and OR5AN1 isolated cilia reveal 10-100fold more sensitivity than existing assays. Tissue from a single animal produces up to 4,000 384-well assay wells, and isolated olfactory cilia can be stored frozen and thus preserved for long term usage. This pipeline offers a sensitive, highly scalable ex vivo odor screening platform that opens the door for decoding human olfaction. One Sentence Summary olfactory-cilia based odor screening platform.

Published
2021

13. Mitochondrial dysfunction in breast cancer

Author

Riar AK, Kenny TC, Takabatake Y, Papa L, and Germain D

Subjects
lcsh:Biology (General), lcsh:QH301-705.5
Abstract

Amanjot Kaur Riar,* Timothy C Kenny,* Yukie Takabatake,* Luena Papa, Doris Germain Division of Hematology/Oncology, Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, NY, USA *These authors have contributed equally to this work Abstract: The reprogramming of the mitochondria of cancer cells is essential for their growth. However, such reprogramming leads to the increased formation of reactive oxygen species, which can lead to damage to the organelle. This review summarizes the mechanisms that protect the mitochondrial network against oxidative stress. Further, since several transcription factors have now been linked to the mitochondrial unfolded protein response (UPRmt) and regulate the expression of one or more genes involved in these "mito-protective" mechanisms, the UPRmt is a prime candidate to coordinate the maintenance of the integrity of the mitochondria under oxidative stress conditions. Keywords: mitochondrial unfolded protein response (UPRmt), mitochondrial DNA, SOD2, reactive oxygen species, breast cancer, mitomiRs, mitochondrial protein quality controls

Published
2015

15. Inhibition of Anodic Dissolution of Steel by Sn2+ in Perchloric Acid Solution.

Author

Takabatake, Y., Sugae, K., Ito, M., Kashima, K., Miyuki, H., and Kamimura, T.

Subjects
PERCHLORIC acid, ANODIC oxidation of metals, ACID solutions, X-ray photoelectron spectroscopy, STEEL, ELECTRODE potential, TIN alloys
Abstract

The inhibition effect of Sn2+ on the anodic dissolution of Fe-0.05C steel was investigated electrochemically in a solution of 0.2 M HClO4. Anodic currents were suppressed in the presence of Sn2+, and the suppression behavior depended on the concentration of Sn2+ and the electrode potentials. The experimental condition for the current suppression is explained by the theory of underpotential deposition (UPD). X-ray photoelectron spectroscopy (XPS) depth analysis revealed the deposition of metallic Sn on the steel, while inductively coupled plasma-mass spectrometry (ICP-MS) analysis demonstrated that the Sn layer thickness was monolayer-level. This strongly suggests that the anodic dissolution of iron was suppressed by the UPD of Sn. The proposed mechanism for corrosion inhibition by Sn-UPD also explains the superior corrosion resistance of Sn-bearing steel under atmospheric environments. [ABSTRACT FROM AUTHOR]

Published
2019
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21. Construction of a Practical SCAR Marker Linked to Clubroot Resistance in Chinese Cabbage, with Intensive Analysis of HC352b Genes

Author

Hayashida, N; HVfmjekV, Takabatake, Y, Nakazawa, N, Aruga, D, Nakanishi, H, Taguchi, G; uCDpjekV, Sakamoto, K, Matsumoto, E, Hayashida, N; HVfmjekV, Takabatake, Y, Nakazawa, N, Aruga, D, Nakanishi, H, Taguchi, G; uCDpjekV, Sakamoto, K, and Matsumoto, E

Abstract

A restriction fragment length polymorphism (RFLP) marker, HC352b, has identified as closely linked to the CRa locus responsible for clubroot resistance (CR) in a study dissecting CR loci in Chinese cabbage (Brassica rapa L. ssp pekinensis). Unfortunately, the RFLP pattern, including HC352b detected by the cDNA clone HC352, was complicated and confused in its interpretation because it represented multiple-copy loci. To provide a practical HC352b marker for CR breeding programs, a sequence characterized amplified region (SCAR) marker was constructed along the analysis of HC352 genes, followed by its evaluation for CR selection. Schematic characterization of signals was achieved by identification of HC352 homologous genes with their restriction sites, employing CRa-positive and -negative doubled haploid (DH) lines. Genomic sequence information from a set of HC352 homologous genes was analyzed to identify the CRa linked paralog HC352b, followed by the successful designation of a SCAR marker. This correctly predicted the CR phenotypes of all tested individuals of F2 and back-crossed progenies.

Published
2010

22. Physics of Heliotron J Confinement

Author

Sano, F, Mizuuchi, T, Nagasaki, Kazunobu, Hanatani, Kiyoshi, Okada, Hiroyuki, Nakamura, Yuji, Minami, Takashi, Kobayashi, Shinji, Yamamoto, Satoshi, Konoshima, S, Ohshima, S, Takeuchi, M, Ijiri, Yoshiyuki, Yaguchi, Keiji, Senju, Tohru, Shibano, Masashi, Toshi, Kiyoshi, Sakamoto, K, Matsuyama, Akinobu, Mukai, K, Minami, K, Kishi, S, Lee, H Y, Takabatake, Y, Yashiro, Hiroaki, Yamamoto, Kento, Nomura, Kohta, Suwa, Masashige, Yoshino, H, Murakami, S, Mutoh, T, Takeiri, Y., Nagaoka, Kenichi, Okamura, S, Watanabe, K, Yokoyama, M, Suzuki, Y, Yoshimura, Yasuo, Nishimura, S, Tamura, N, Sakakibara, Satoru, MOTOJIMA, Gen, NISHINO, Nobuhiro, Fukuda, T, NAKASHIMA, Yousuke, Feng, Zhen, YANG, Qingwei, Fernandez, A, Cappa, A, Tribaldos, V, Blackwell, Boyd, CHECHKIN, Viktor V., Sano, F, Mizuuchi, T, Nagasaki, Kazunobu, Hanatani, Kiyoshi, Okada, Hiroyuki, Nakamura, Yuji, Minami, Takashi, Kobayashi, Shinji, Yamamoto, Satoshi, Konoshima, S, Ohshima, S, Takeuchi, M, Ijiri, Yoshiyuki, Yaguchi, Keiji, Senju, Tohru, Shibano, Masashi, Toshi, Kiyoshi, Sakamoto, K, Matsuyama, Akinobu, Mukai, K, Minami, K, Kishi, S, Lee, H Y, Takabatake, Y, Yashiro, Hiroaki, Yamamoto, Kento, Nomura, Kohta, Suwa, Masashige, Yoshino, H, Murakami, S, Mutoh, T, Takeiri, Y., Nagaoka, Kenichi, Okamura, S, Watanabe, K, Yokoyama, M, Suzuki, Y, Yoshimura, Yasuo, Nishimura, S, Tamura, N, Sakakibara, Satoru, MOTOJIMA, Gen, NISHINO, Nobuhiro, Fukuda, T, NAKASHIMA, Yousuke, Feng, Zhen, YANG, Qingwei, Fernandez, A, Cappa, A, Tribaldos, V, Blackwell, Boyd, and CHECHKIN, Viktor V.

Published
2010

23. ECCD Experiments Using the Upgraded Launching System in Heliotron J

Author

Nagasaki, Kazunobu, Sakamoto, K, Minami, K, Yoshino, H, Mizuuchi, T, Okada, Hiroyuki, Hanatani, Kiyoshi, Minami, T, Masuda, K, Kobayashi, Shinji, Yamamoto, Satoshi, Konoshima, S, Nakamura, Yuji, Ohshima, S, Mukai, K, Kishi, S, Lee, H Y, Takabatake, Y, Motojima, G, Yoshimura, Yasuo, Fernandez, A, Cappa, A, Blackwell, Boyd, Sano, F, Nagasaki, Kazunobu, Sakamoto, K, Minami, K, Yoshino, H, Mizuuchi, T, Okada, Hiroyuki, Hanatani, Kiyoshi, Minami, T, Masuda, K, Kobayashi, Shinji, Yamamoto, Satoshi, Konoshima, S, Nakamura, Yuji, Ohshima, S, Mukai, K, Kishi, S, Lee, H Y, Takabatake, Y, Motojima, G, Yoshimura, Yasuo, Fernandez, A, Cappa, A, Blackwell, Boyd, and Sano, F

Abstract

Electron cyclotron current drive (ECCD) experiments have been made in Heliotron J by using an upgraded EC launching system. A focused Gaussian beam is injected with the parallel refractive index, N, ranging from -0.05 to 0.6. Ray tracing calculation shows that the EC power is more localized than that in the previous launching system. In the initial ECCD experiment, the EC injection angle has been successfully scanned as designed. Comparison between perpendicular and oblique launching experiments shows that for standard configuration, the EC current of 1 kA is driven at N, ~ 0.3 in the Fisch-Boozer direction, and the bootstrap current flows up to 1 kA. A large increase in electron cyclotron emission (ECE) signals has been observed when the EC current was driven.

Published
2010

26. Experimental pathology

Author

Yi Chun, D. X., primary, Alexandre, H., additional, Edith, B., additional, Nacera, O., additional, Julie, P., additional, Chantal, J., additional, Eric, R., additional, Zhang, X., additional, Jin, Y., additional, Miravete, M., additional, Dissard, R., additional, Klein, J., additional, Gonzalez, J., additional, Caubet, C., additional, Pecher, C., additional, Pipy, B., additional, Bascands, J.-L., additional, Mercier-Bonin, M., additional, Schanstra, J., additional, Buffin-Meyer, B., additional, Claire, R., additional, Rigothier, C., additional, Richard, D., additional, Sebastien, L., additional, Moin, S., additional, Chantal, B., additional, Christian, C., additional, Jean, R., additional, Migliori, M., additional, Cantaluppi, V., additional, Mannari, C., additional, Medica, D., additional, Giovannini, L., additional, Panichi, V., additional, Goldwich, A., additional, Alexander, S., additional, Andre, G., additional, Amann, K., additional, Migliorini, A., additional, Sagrinati, C., additional, Angelotti, M. L., additional, Mulay, S. R., additional, Ronconi, E., additional, Peired, A., additional, Romagnani, P., additional, Anders, H.-J., additional, Chiang, W. C., additional, Lai, C. F., additional, Peng, W.-H., additional, Wu, C. F., additional, Chang, F.-C., additional, Chen, Y.-T., additional, Lin, S.-L., additional, Chen, Y. M., additional, Wu, K. D., additional, Lu, K.-S., additional, Tsai, T. J., additional, Virgine, O., additional, Qing Feng, F., additional, Zhang, S.-Y., additional, Dominique, D., additional, Vincent, A., additional, Marina, C., additional, Philippe, L., additional, Georges, G., additional, Pawlak, A., additional, Sahali, D., additional, Matsumoto, S., additional, Kiyomoto, H., additional, Ichimura, A., additional, Dan, T., additional, Nakamichi, T., additional, Tsujita, T., additional, Akahori, K., additional, Ito, S., additional, Miyata, T., additional, Xie, S., additional, Zhang, B., additional, Shi, W., additional, Yang, Y., additional, Nagasu, H., additional, Satoh, M., additional, Kidokoro, K., additional, Nishi, Y., additional, Ihoriya, C., additional, Kadoya, H., additional, Sasaki, T., additional, Kashihara, N., additional, Wu, C.-F., additional, Chou, Y.-H., additional, Duffield, J., additional, Rocca, C., additional, Gregorini, M., additional, Corradetti, V., additional, Valsania, T., additional, Bedino, G., additional, Bosio, F., additional, Pattonieri, E. F., additional, Esposito, P., additional, Sepe, V., additional, Libetta, C., additional, Rampino, T., additional, Dal Canton, A., additional, Omori, H., additional, Kawada, N., additional, Inoue, K., additional, Ueda, Y., additional, Yamamoto, R., additional, Matsui, I., additional, Kaimori, J., additional, Takabatake, Y., additional, Moriyama, T., additional, Isaka, Y., additional, Rakugi, H., additional, Wasilewska, A., additional, Taranta-Janusz, K., additional, Deebek, W., additional, Kuroczycka-Saniutycz, E., additional, Lee, A. S., additional, Lee, J. E., additional, Jung, Y. J., additional, Kang, K. P., additional, Lee, S., additional, Kim, W., additional, Arfian, N., additional, Emoto, N., additional, Yagi, K., additional, Nakayama, K., additional, Hartopo, A. B., additional, Nugrahaningsih, D. A., additional, Yanagisawa, M., additional, Hirata, K.-I., additional, Munoz-Felix, J. M., additional, Lopez-Novoa, J. M., additional, Martinez-Salgado, C., additional, Oujo, B., additional, Arevalo, M., additional, Bernabeu, C., additional, Perez-Barriocanal, F., additional, Jesper, K., additional, Nathalie, V., additional, Pierre, G., additional, Yi Chun, D. X., additional, Iyoda, M., additional, Shibata, T., additional, Matsumoto, K., additional, Shindo-Hirai, Y., additional, Kuno, Y., additional, Wada, Y., additional, Akizawa, T., additional, Schwartz, I., additional, Schwartz, D., additional, Prot Bertoye, C., additional, Terryn, S., additional, Claver, J., additional, Beghdadi, W. B., additional, Monteiro, R., additional, Blank, U., additional, Devuyst, O., additional, Daugas, E., additional, Van Beneden, K., additional, Geers, C., additional, Pauwels, M., additional, Mannaerts, I., additional, Van den Branden, C., additional, Van Grunsven, L. A., additional, Seckin, I., additional, Pekpak, M., additional, Uzunalan, M., additional, Uruluer, B., additional, Kokturk, S., additional, Ozturk, Z., additional, Sonmez, H., additional, Yaprak, E., additional, Furuno, Y., additional, Tsutsui, M., additional, Morishita, T., additional, Shimokawa, H., additional, Otsuji, Y., additional, Yanagihara, N., additional, Kabashima, N., additional, Ryota, S., additional, Kanegae, K., additional, Miyamoto, T., additional, Nakamata, J., additional, Ishimatsu, N., additional, Tamura, M., additional, Nakagawa, T., additional, Ichikawa, K., additional, Miyamoto, M., additional, Takabayashi, D., additional, Yamazaki, H., additional, Kakeshita, K., additional, Koike, T., additional, Kagitani, S., additional, Tomoda, F., additional, Hamashima, T., additional, Ishii, Y., additional, Inoue, H., additional, Sasahara, M., additional, El Machhour, F., additional, Kerroch, M., additional, Mesnard, L., additional, Chatziantoniou, C., additional, Dussaule, J.-C., additional, Inui, K., additional, Sasai, F., additional, Maruta, Y., additional, Nishiwaki, H., additional, Kawashima, E., additional, Inoue, Y., additional, Yoshimura, A., additional, Musacchio, E., additional, Priante, G., additional, Valvason, C., additional, Sartori, L., additional, Baggio, B., additional, Kim, J. H., additional, Gross, O., additional, Diana, R., additional, Gry, D. H., additional, Asimal, B., additional, Johanna, T., additional, Imke, S.-E., additional, Lydia, W., additional, Gerhard-Anton, M., additional, Hassan, D., additional, Cano, J. L., additional, Griera, M., additional, Olmos, G., additional, Martin, P., additional, Cortes, M. A., additional, Lopez-Ongil, S., additional, Rodriguez-Puyol, D., additional, DE Frutos, S., additional, Gonzalez, M., additional, Luengo, A., additional, Rodriguez-Puyol, M., additional, Calleros, L., additional, Lupica, R., additional, Lacquaniti, A., additional, Donato, V., additional, Maggio, R., additional, Mastroeni, C., additional, Lucisano, S., additional, Cernaro, V., additional, Fazio, M. R., additional, Quartarone, A., additional, Buemi, M., additional, Kacik, M., additional, Goedicke, S., additional, Eggert, H., additional, Hoyer, J. D., additional, Wurm, S., additional, Steege, A., additional, Banas, M., additional, Kurtz, A., additional, Banas, B., additional, Lasagni, L., additional, Lazzeri, E., additional, Romoli, S., additional, Schaefer, I., additional, Teng, B., additional, Worthmann, K., additional, Haller, H., additional, Schiffer, M., additional, Prattichizzo, C., additional, Netti, G. S., additional, Rocchetti, M. T., additional, Cormio, L., additional, Carrieri, G., additional, Stallone, G., additional, Grandaliano, G., additional, Ranieri, E., additional, Gesualdo, L., additional, Kucher, A., additional, Smirnov, A., additional, Parastayeva, M., additional, Beresneva, O., additional, Kayukov, I., additional, Zubina, I., additional, Ivanova, G., additional, Abed, A., additional, Schlekenbach, L., additional, Foglia, B., additional, Kwak, B., additional, Chadjichristos, C., additional, Queisser, N., additional, Schupp, N., additional, Brand, S., additional, Himer, L., additional, Szebeni, B., additional, Sziksz, E., additional, Saijo, S., additional, Kis, E., additional, Prokai, A., additional, Banki, N. F., additional, Fekete, A., additional, Tulassay, T., additional, Vannay, A., additional, Hegner, B., additional, Schaub, T., additional, Lange, C., additional, Dragun, D., additional, Klinkhammer, B. M., additional, Rafael, K., additional, Monika, M., additional, Anna, M., additional, Van Roeyen, C., additional, Boor, P., additional, Eva Bettina, B., additional, Simon, O., additional, Esther, S., additional, Floege, J., additional, Kunter, U., additional, Janke, D., additional, Jankowski, J., additional, Hayashi, M., additional, Takamatsu, I., additional, Horimai, C., additional, Yoshida, T., additional, Seno DI Marco, G., additional, Koenig, M., additional, Stock, C., additional, Reiermann, S., additional, Amler, S., additional, Koehler, G., additional, Fobker, M., additional, Buck, F., additional, Pavenstaedt, H., additional, Lang, D., additional, Brand, M., additional, Plotnikov, E., additional, Morosanova, M., additional, Pevzner, I., additional, Zorova, L., additional, Pulkova, N., additional, Zorov, D., additional, Wornle, M., additional, Ribeiro, A., additional, Belling, F., additional, Merkle, M., additional, Nakazawa, D., additional, Nishio, S., additional, Shibasaki, S., additional, Tomaru, U., additional, Akihiro, I., additional, Kobayashi, I., additional, Imanishi, Y., additional, Kurajoh, M., additional, Nagata, Y., additional, Yamagata, M., additional, Emoto, M., additional, Michigami, T., additional, Ishimura, E., additional, Inaba, M., additional, Wu, C.-C., additional, Lu, K.-C., additional, Chen, J.-S., additional, Chu, P., additional, Lin, Y.-F., additional, Eller, K., additional, Schroll, A., additional, Kirsch, A., additional, Huber, J., additional, Weiss, G., additional, Theurl, I., additional, Rosenkranz, A. R., additional, Zawada, A., additional, Rogacev, K., additional, Achenbach, M., additional, Fliser, D., additional, Held, G., additional, Heine, G. H., additional, Miyamoto, Y., additional, Iwao, Y., additional, Watanabe, H., additional, Kadowaki, D., additional, Ishima, Y., additional, Chuang, V. T. G., additional, Sato, K., additional, Otagiri, M., additional, Maruyama, T., additional, Iwatani, H., additional, Honda, D., additional, Noguchi, T., additional, Tanaka, M., additional, Tanaka, H., additional, Fukagawa, M., additional, Pircher, J., additional, Koppel, S., additional, Mannell, H., additional, Krotz, F., additional, Virzi, G. M., additional, Bolin, C., additional, Cruz, D., additional, Scalzotto, E., additional, De Cal, M., additional, Vescovo, G., additional, Ronco, C., additional, Grobmayr, R., additional, Lech, M., additional, Ryu, M., additional, Aoshima, Y., additional, Mizobuchi, M., additional, Ogata, H., additional, Kumata, C., additional, Nakazawa, A., additional, Kondo, F., additional, Ono, N., additional, Koiwa, F., additional, Kinugasa, E., additional, Freisinger, W., additional, Lale, N., additional, Lampert, A., additional, Ditting, T., additional, Heinlein, S., additional, Schmieder, R. E., additional, Veelken, R., additional, Nave, H., additional, Perthel, R., additional, Suntharalingam, M., additional, Bode-Boger, S., additional, Beutel, G., additional, Kielstein, J., additional, Rodrigues-Diez, R., additional, Rayego-Mateos, S., additional, Lavoz, C., additional, Stark Aroeira, L. G., additional, Orejudo, M., additional, Alique, M., additional, Ortiz, A., additional, Egido, J., additional, Ruiz-Ortega, M., additional, Oskar, W., additional, Rusan, C., additional, Padberg, J.-S., additional, Wiesinger, A., additional, Reuter, S., additional, Grabner, A., additional, Kentrup, D., additional, Lukasz, A., additional, Oberleithner, H., additional, Pavenstadt, H., additional, Kumpers, P., additional, Eberhardt, H. U., additional, Skerka, C., additional, Chen, Q., additional, Hallstroem, T., additional, Hartmann, A., additional, Kemper, M. J., additional, Zipfel, P. F., additional, N'gome-Sendeyo, K., additional, Fan, Q.-F., additional, Toblli, J., additional, Cao, G., additional, Giani, J. F., additional, Dominici, F. P., additional, Kim, J. S., additional, Yang, J. W., additional, Kim, M. K., additional, Han, B. G., additional, and Choi, S. O., additional

Published
2012
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27. Experimental pathology

Author

McCabe, K., primary, Shobeiri, N., additional, Beseau, D., additional, Adams, M., additional, Holden, R., additional, Maio, T., additional, McCabe, K., additional, Laverty, K., additional, Pang, J., additional, Jozefacki, A., additional, Salem, S., additional, Jankowski, V., additional, Passlick-Deetjen, J., additional, Peter, M., additional, Zidek, W., additional, Jankowski, J., additional, Riser, B., additional, Barreto, F., additional, Valaitis, P., additional, Cook, C., additional, White, J., additional, Drueke, T., additional, Holmes, C., additional, Massy, Z., additional, Mizobuchi, M., additional, Ogata, H., additional, Kumata, C., additional, Nakazawa, A., additional, Koiwa, F., additional, Kinugasa, E., additional, Akizawa, T., additional, Lopez, I., additional, Aguilera-Tejero, E., additional, Guerrero, F., additional, Pineda, C., additional, Raya, A. I., additional, Peralta, A., additional, Rodriguez, M., additional, Ciceri, P., additional, Volpi, E., additional, Brenna, I., additional, Brancaccio, D., additional, Cozzolino, M., additional, Bozic, M., additional, deRoij, J., additional, Parisi, E., additional, Ruiz-Ortega, M., additional, Fernandez, E., additional, Valdivielso, J. M., additional, Lee, C.-T., additional, Ng, H.-Y., additional, Tsai, Y.-C., additional, Yang, Y.-K., additional, Niwa, T., additional, Adijiang, A., additional, Shimizu, H., additional, Nishijima, F., additional, Okamoto, T., additional, Kamata, K., additional, Naito, S., additional, Aoyama, T., additional, Tazaki, H., additional, Yamanaka, N., additional, Koenigshausen, E., additional, Ohlsson, S., additional, Woznowski, M., additional, Quack, I., additional, Potthoff, S. A., additional, Rump, L. C., additional, Sellin, L., additional, Maquigussa, E., additional, Pereira, L., additional, Arnoni, C., additional, Boim, M., additional, Lee, K. W., additional, Jeong, J. Y., additional, Jang, W. I., additional, Chung, S., additional, Choi, D. E., additional, Na, K.-R., additional, Shin, Y. T., additional, Slabiak-Blaz, N., additional, Adamczak, M., additional, Ritz, E., additional, Wiecek, A., additional, Uz, E., additional, Uz, B., additional, Sahin Balcik, O., additional, Kaya, A., additional, Akdeniz, D., additional, Bavbek Ruzgaresen, N., additional, Turgut, F. H., additional, Bayrak, R., additional, Carlioglu, A., additional, Akcay, A., additional, Galichon, P., additional, Vittoz, N., additional, Cornaire, E., additional, Baugey, E., additional, Vandermeersch, S., additional, Verpont, M.-C., additional, Mesnard, L., additional, Xu-Dubois, Y.-C., additional, Hertig, A., additional, Rondeau, E., additional, Kokeny, G., additional, Fekeshazy, O., additional, Fang, L., additional, Rosivall, L., additional, Mozes, M. M., additional, Duggan, K., additional, Hodge, G., additional, Ha, H., additional, Chen, J., additional, Lee, L., additional, Tay, C., additional, Macdonald, G., additional, Wang, P. H. M., additional, Tamouza, H., additional, Chemouny, J., additional, Monsinjon, E., additional, Tiwari, M., additional, Vende, F., additional, Vrtovsnik, F., additional, Camara, N. O., additional, Benhamou, M., additional, Monteiro, R. C., additional, Moura, I. C., additional, Rigothier, C., additional, Saleem, M., additional, Ripoche, J., additional, Mathieson, P., additional, Combe, C., additional, Welsh, G., additional, Duwel, A., additional, Munoz-Felix, J. M., additional, Lopez-Novoa, J. M., additional, Martinez-Salgado, C., additional, Koutroutsos, K., additional, Kassimatis, T., additional, Nomikos, A., additional, Giannopoulou, I., additional, Papadakis, J., additional, Nakopoulou, L., additional, Nakamichi, T., additional, Mori, T., additional, Sato, T., additional, Sato, H., additional, Ito, S., additional, Neudecker, S., additional, Heilmann, M., additional, Kramer, P., additional, Wolf, I., additional, Sticht, C., additional, Schock-Kusch, D., additional, Gubhaju, L., additional, Kriz, W., additional, Bertram, J. F., additional, Schad, L. R., additional, Gretz, N., additional, Fuentes-Calvo, I., additional, Kimura, T., additional, Takabatake, Y., additional, Takahashi, A., additional, Kaimori, J.-y., additional, Matsui, I., additional, Namba, T., additional, Kitamura, H., additional, Niimura, F., additional, Matsusaka, T., additional, Soga, T., additional, Rakugi, H., additional, Isaka, Y., additional, Shin, S. J., additional, Kim, K. S., additional, Kim, W. K., additional, Rampanelli, E., additional, Teske, G., additional, Leemans, J., additional, Florquin, S., additional, Small, D., additional, Bennett, N., additional, Roy, S., additional, Gobe, G., additional, Blazquez-Medela, A. M., additional, Garcia-Sanchez, O., additional, Lopez-Hernandez, F. J., additional, Deibel, A., additional, Cheng, J., additional, Warner, G., additional, Knudsen, B., additional, Gray, C., additional, Lien, K., additional, Juskewitch, J., additional, Grande, J., additional, Wang, N., additional, Wang, X., additional, Zeng, M., additional, Sun, B., additional, Xing, C., additional, Zhao, X., additional, Xiong, M., additional, Yang, J., additional, Cao, K., additional, Priante, G., additional, Musacchio, E., additional, Sartori, L., additional, Valvason, C., additional, Baggio, B., additional, Pitlovanciv, E. d. O. N., additional, Reis, L. A., additional, Pessoa, E. A., additional, Teixeira, L., additional, Borges, F. T., additional, Simoes, M. J., additional, Schor, N., additional, Doustar, Y., additional, Mohajeri, D., additional, Smirnov, A. V., additional, Kucher, A. G., additional, Ivanova, G. T., additional, Berseneva, O. N., additional, Parastaeva, M. M., additional, Zarajsky, M. I., additional, Saburova, I. J., additional, Kaukov, I. G., additional, Koppe, L., additional, Fouque, D., additional, Dugenet, Y., additional, Soulage, C., additional, Wan, J., additional, Yang, X., additional, Cui, J., additional, and Zou, Z., additional

Published
2011
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28. Acute kidney injury - Experimental models

Author

Nagasaki, Y., primary, Yoshitomi, T., additional, Hirayama, A., additional, Schock-Kusch, D., additional, Xie, Q., additional, Shulhevich, Y., additional, Hesser, J., additional, Stsepankou, S., additional, Koenig, S., additional, Heinrich, R., additional, Pill, J., additional, Gretz, N., additional, Efrati, S., additional, Berman, S., additional, Abu-Hamad, R., additional, Siman-Tov, Y., additional, Weissgarten, J., additional, Kimura, T., additional, Takabatake, Y., additional, Takahashi, A., additional, Kaimori, J.-y., additional, Matsui, I., additional, Namba, T., additional, Kitamura, H., additional, Niimura, F., additional, Matsusaka, T., additional, Rakugi, H., additional, Isaka, Y., additional, Ito, K., additional, Watanabe, M., additional, Nakashima, H., additional, Abe, Y., additional, Ifuku, M., additional, Nishimura, S., additional, Saito, T., additional, Mulay, S. R., additional, Thomasova, D., additional, Ryu, M., additional, Anders, H.-J., additional, Nakayama, Y., additional, Ueda, S., additional, Yamagishi, S.-i., additional, Ando, R., additional, Kaida, Y., additional, Iwatani, R., additional, Fujimi, A., additional, Fukami, K., additional, Okuda, S., additional, Shin, Y. T., additional, Jeong, J. Y., additional, Jang, W. I., additional, Chung, S., additional, Choi, D. E., additional, Na, K. R., additional, Lee, K. W., additional, Mugitani, N., additional, Shimizu, Y., additional, Satake, K., additional, Suzuki, Y., additional, Horikoshi, S., additional, Tomino, Y., additional, Schneider, R., additional, Meusel, M., additional, Betz, B., additional, Wanner, C., additional, Koepsell, H., additional, Sauvant, C., additional, Dursun, B., additional, Abban, G., additional, Kucukatay, V., additional, Tufan, L., additional, Dodurga, Y., additional, Guclu, A., additional, Gok, D., additional, Vicente-Vicente, L., additional, Sanchez-Gonzalez, P. D., additional, Prieto, M., additional, Lopez-Novoa, J. M., additional, Lopez-Hernandez, F. J., additional, Morales, A. I., additional, Torres, A., additional, Dnyanmote, A., additional, Wu, W., additional, Nigam, S., additional, Wystrychowski, A., additional, Wystrychowski, W., additional, Kolodziejczyk, A., additional, Obuchowicz, E., additional, Wiecek, A., additional, Reis, L. A., additional, Borges, F. T., additional, Simoes, M. d. J., additional, Schor, N., additional, Mesnard, L., additional, Rafat, C., additional, Vandermeersch, S., additional, Nochy, D., additional, Garcon, L., additional, Callard, P., additional, Jouanneau, C., additional, Verpont, M.-C., additional, Hertig, A., additional, Rondeau, E., additional, Grosjean, F., additional, Torreggiani, M., additional, Esposito, V., additional, Mangione, F., additional, Serpieri, N., additional, Villa, L., additional, Sileno, G., additional, Marchi, G., additional, Fasoli, G., additional, Esposito, C., additional, Dal Canton, A., additional, Sancho-Martinez, S., additional, Striker, G., additional, Vlassara, H., additional, Zheng, F., additional, Park, D. J., additional, Kim, J. H., additional, Jung, M. H., additional, Seo, J. W., additional, Kim, H.-j., additional, Chang, S.-H., additional, Han, B.-G., additional, Yang, J.-W., additional, Yu, J.-M., additional, Choi, S.-O., additional, Christo, J. S., additional, Rusai, K., additional, Prokai, A., additional, Szebeni, B., additional, Meszaros, K., additional, Fekete, A., additional, Treszl, A., additional, Vannay, A., additional, Muller, V., additional, Reusz, G., additional, Heemann, U., additional, Tulassay, T., additional, Lutz, J., additional, Szabo, A. J., additional, Ranghino, A., additional, Bruno, S., additional, Grange, C., additional, Dolla, C., additional, Cantaluppi, V., additional, Biancone, L., additional, Tetta, C., additional, Segoloni, G. P., additional, Camussi, G., additional, Pinto, V., additional, Teixeira, V., additional, Almeida, W., additional, Fujikura, T., additional, Sun, Y., additional, Iwakura, T., additional, Yasuda, H., additional, Fujigaki, Y., additional, Simone, S., additional, Rascio, F., additional, Loverre, A., additional, Cosola, C., additional, Cariello, M., additional, Castellano, G., additional, Ditonno, P., additional, Schena, F. P., additional, Gesualdo, L., additional, Grandaliano, G., additional, Pertosa, G., additional, Choi, J.-Y., additional, Kim, J., additional, Jin, D.-C., additional, Cha, J.-H., additional, Kaynar, K., additional, Aliyazicioglu, R., additional, Ersoz, S., additional, Ulusoy, S., additional, Al, S., additional, Ozkan, G., additional, Cansiz, M., additional, Fuchs, T. C., additional, Emde, B., additional, Czasch, S., additional, von Landenberg, F., additional, Hewitt, P., additional, Abu-Salah, N., additional, Bishara, B., additional, Awad, H., additional, Ghrayeb, N., additional, Assady, S., additional, Armaly, Z., additional, Better, O., additional, and Abassi, Z., additional

Published
2011
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29. Plasma startup using neutral beam injection assisted by 2.45 GHz microwaves in Heliotron J

Author

Kobayashi, S., primary, Nagasaki, K., additional, Yamamoto, S., additional, Sakamoto, K., additional, Mizuuchi, T., additional, Okada, H., additional, Minami, T., additional, Hanatani, K., additional, Nakamura, Y., additional, Konoshima, S., additional, Ohshima, S., additional, Takeuchi, M., additional, Mukai, K., additional, Lee, H.Y., additional, Kishi, S., additional, Minami, K., additional, Takabatake, Y., additional, Yoshino, H., additional, and Sano, F., additional

Published
2011
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30. STUDY OF 70GHZ SECOND HARMONIC X-MODE ECCD IN HELIOTRON J

Author

NAGASAKI, K., primary, MINAMI, K., additional, YOSHINO, H., additional, SAKAMOTO, K., additional, YAMAMOTO, S., additional, MIZUUCHI, T., additional, OKADA, H., additional, HANATANI, K., additional, MINAMI, T., additional, MASUDA, K., additional, KOBAYASHI, S., additional, KONOSHIMA, S., additional, TAKEUCHI, M., additional, NAKAMURA, Y., additional, OHSHIMA, S., additional, MUKAI, K., additional, KISHI, S., additional, LEE, H. Y., additional, TAKABATAKE, Y., additional, YOSHIMURA, Y., additional, MOTOJIMA, G., additional, CAPPA, Á., additional, BLACKWELL, B., additional, and SANO, F., additional

Published
2011
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33. Effects of Supersonic Molecular Beam Injection (SMBI) on Plasma Performance in Heliotron J

Author

Mizuuchi, T., primary, Kobayashi, S., additional, Yamamoto, Y., additional, Okada, H., additional, Nagasaki, K., additional, Minami, T., additional, Watanabe, S., additional, Mukai, K., additional, Kishi, S., additional, Lee, H. Y., additional, Minami, K., additional, Takabatake, Y., additional, Nishino, N., additional, Nakashima, Y., additional, Nakamura, Y., additional, Hanatani, K., additional, Konoshima, S., additional, and Sano, F., additional

Published
2010
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34. ECCD Experiments Using the Upgraded Launching System in Heliotron J

Author

Nagasaki, K., primary, Sakamoto, K., additional, Minami, K., additional, Yoshino, H., additional, Mizuuchi, T., additional, Okada, H., additional, Hanatani, K., additional, Minami, T., additional, Masuda, K., additional, Kobayashi, S., additional, Yamamoto, S., additional, Konoshima, S., additional, Nakamura, Y., additional, Ohshima, S., additional, Mukai, K., additional, Kishi, S., additional, Lee, H. Y., additional, Takabatake, Y., additional, Motojima, G., additional, Yoshimura, Y., additional, Fernández, A., additional, Cappa, Á., additional, Blackwell, B., additional, and Sano, F., additional

Published
2010
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35. Electron Density Profile Measurement in Heliotron J with a Microwave AM Reflectometer

Author

Mukai, K., primary, Nagasaki, K., additional, Zhuravlev, V., additional, Fukuda, T., additional, Mizuuchi, T., additional, Minami, T., additional, Okada, H., additional, Kobayashi, S., additional, Yamamoto, S., additional, Hanatani, K., additional, Konoshima, S., additional, Ohshima, S., additional, Takeuchi, M., additional, Nishi, D., additional, Minami, K., additional, Lee, H.Y., additional, Takabatake, Y., additional, Kishi, S., additional, Yashiro, H., additional, and Sano, F., additional

Published
2010
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44. Carbon-Free Pt Electrocatalysts Supported on SnO2 for Polymer Electrolyte Fuel Cells: Electrocatalytic Activity and Durability.

Author

Takasaki, F., Matsuie, S., Takabatake, Y., Noda, Z., Hayashi, A., Shiratori, Y., Ito, K., and Sasaki, K.

Abstract

The use of SnO2 as an alternative electrocatalyst support improves durability against voltage cycling up to a high potential, conesponding to the start-up and shut-down situation of polymer electrolyte fuel cell (PEFC) systems. Electrochemical surface area (ECSA) and oxygen reduction reaction (ORR) activity of Pt electrocatalysts as well as electrical conductivity of the electrocatalyst layers increase by doping of SnO2 with Nb or Sb. The durability tests with voltage cycles between 0.9 and 1.3 V versus reversible hydrogen electrode (RHE) potential have revealed that the Pt electrocatalyst supported on SnO2 (Pt/SnO2) withstands 60,000 voltage cycles while maintaining its ECSA, which corresponds to a lifetime of more than 20 years with respect to the durability against voltage cycling. These results indicate that SnO2-supported carbon-free electrocatalysts can be alternatives to the conventional Pt/C electrocatalyst, as a fundamental solution against carbon support corrosion, to improve PEFC durability. [ABSTRACT FROM AUTHOR]

Published
2011
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46. Predictors of pressure ulcer and physical restraint prevalence in Japanese acute care units.

Author

Ibe T, Ishizaki T, Oku H, Ota K, Takabatake Y, Iseda A, Ishikawa Y, and Ueda A

Abstract

Aim: To investigate the predictors of pressure ulcer and physical restraint prevalence in Japanese acute care units and their relationship to the nursing hours, skill mix, and Nursing Need Scores (NNS). Methods: In this descriptive study, quantitative methods were employed to determine if pressure ulcers and physical restraint prevalence, as outcomes of nursing care, were related to the nursing hours, skill mix, and intensity of nursing-care needs. The sample included 87 acute care units in 42 hospitals in Tokyo and its surrounding prefectures in Japan. The NNS was used as the instrument to measure the intensity of nursing-care needs. The data were analyzed with descriptive statistics, correlations, and multiple regression analyses. Results: Pressure ulcer prevalence was positively correlated with the NNS-A and NNS-B. Physical restraint use was positively correlated with the NNS-B and negatively correlated with the NNS-A. However, the total nursing hours per patient day was positively related with both pressure ulcer and physical restraint prevalence. Conclusions: The nursing hours and NNS are predictors of pressure ulcer development and physical restraint use. The results also suggest that we should revise our process of nursing care. Many functions that might be shared with other personnel are performed by nurses, which results in longer total nursing hours but shorter direct nursing hours, used in order to observe and care for patients. Japan's aging population will result in higher NNS, requiring more direct nursing hours and other personnel to participate in our process of nursing care. [ABSTRACT FROM AUTHOR]

Published
2008
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