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153 results on '"Takada, Ritsuko"'

12. Identification of the laminar-inducing factor: Wnt-signal from the anterior rim induces correct laminar formation of the neural retina in vitro

Author

Nakagawa, Shinichi, Takada, Shinji, Takada, Ritsuko, and Takeichi, Masatoshi

Subjects
Cell differentiation -- Research, Developmental biology -- Research, Retina -- Physiological aspects, Retina -- Research, Biological sciences
Abstract

To study the molecular mechanism that controls the laminar organization of the retina, we utilized reaggregation cultures of dissociated retinal cells prepared from chicken embryos. These cells cannot generate laminated structures by themselves and, instead, form rosettes within the reaggregates. However, the dissociated cells can organize into a correctly laminated structure when cultured in the presence of a putative laminar inducing factor coming from particular tissue or cells, but its molecular identity of this factor has long remained elusive. In this study, we found that the anterior rim of the retina sends a signal to rearrange the rosette-forming cells into a neuroepithelial structure characteristic of the undifferentiated retinal layer. This activity of the anterior rim was mimicked by Wnt-2b expressed in this tissue, and was neutralized by a soluble form of Frizzled, which works as a Wnt antagonist. Furthermore, the neuroepithelial structure induced by Wnt-2b subsequently developed into correctly laminated retinal layers. These observations suggest that the anterior rim functions as a layer-organizing center in the retina, by producing Wnt-2b. Keywords: Retina; Wnt; Layer; Laminar formation; Conditioned medium; Reaggregation; Anterior rim; Regeneration; Differentiation; Pigment epithelium

Published
2003

18. Evolutionary conservation of human TATA-binding-polypeptide associated factors TAF(sub II)31 and TAF(sub II)80 and interactions of TAF(sub II)80 with other TAFs and with general transcription factors

Author

Hisatake, Koji, Ohta, Tsutomu, Takada, Ritsuko, Guermah, Mohamed, Horikoshi, Masami, Nakatani, Yoshihiro, and Roeder, Robert G.

Subjects
Polypeptides -- Analysis, Science and technology
Abstract

An analysis of the human transcription initiation factor, TFIID, composed of the TATA-binding polypeptide (TBP) and TBP-associated factors (TAFs) revealed that TAF(sub II)80 interacts with TAF(sub II)250, TAF(sub II)31, TAF(sub II)20, and TAP while TAF(sub II)80 interacts with TRIIEalpha and TRIIFalpha. The mutation of TAF(sub II)80 indicated three distinct interaction domains falling within regions conserved in human TAF(sub II)80, Drosophila TAF(sub II)60, and yeast TAF(sub II)60. This process of isolating these cDNAs are discussed.

Published
1995

19. Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants

Author

Marti, Elisa, Bumcrot, David A., Takada, Ritsuko, and McMahon, Andrew P.

Subjects
Central nervous system -- Research, Hedgehogs -- Genetic aspects, Vertebrates -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

A vertebrate from the hedgehog family known as the Sonic hedgehog (Shh) is processed to generate the peptides Mr 19K and 26/27K. In vitro experiments conducted on various vertebrate embryos and neural explants show that Shh is capable of mediating floor-plate induction. Recombinant Shh peptides are applied to neural explants in serum-free conditions. Shh is proposed to display morphogenic qualities to induce different ventral cell types in the central nervous system of the vertebrate.

Published
1995

22. Identification of human TFIID components and direct interaction between a 250-dKa polypeptide and the TATA box-binding protein (TFIID-tau)

Author

Takada, Ritsuko, Nakatani, Yoshihiro, Hoffmann, Alexander, Kokubo, Tetsuro, Hasegawa, Satoshi, Roeder, Robert G., and Horikoshi, Masami

Subjects
RNA polymerases -- Analysis, Genetic transcription -- Research, Science and technology
Abstract

Transcription initiation factor IID (TFIID) is composed of a TATA-binding subunit, TBP, and other polypeptides which may be involved for promoter interactions and activator-dependent transcription. Using a TBP-specific antibody column, a number of human TFIID polypeptides which are associated with TBP were isolated. Further characterization of these polypeptides demonstrated that at least one of them could interact directly with TBP. These polypeptides may play a major role in the assembly and function of TFIID.

Published
1992

30. The p250 subunit of native TATA box-binding factor TFIID is the cell-cycle regulatory protein CCG1

Author

Hisatake, Koji, Hasegawa, Satoshi, Takada, Ritsuko, Nakatani, Yoshihiro, Horikoshi, Masami, and Roeder, Robert G.

Subjects
Cell cycle -- Research, Genetic transcription -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Previous research findings indicate that subunits of the transcription factor TFIID other than the TATA-binding polypeptide must be essential cofactors and potential targets for activators. A 250K subunit of TFIID was identified and found to be identical to a gene product that has been implicated in progression through the late G1 phase of the cell cycle. The findings suggest that a portion of p250 may play a role in the activation of a subset of genes essential to cell cycle progression.

Published
1993

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Author

Tokue, Moe, Ikami, Kanako, Mizuno, Seiya, Takagi, Chiyo, Miyagi, Asuka, Takada, Ritsuko, Noda, Chiyo, Kitadate, Yu, Hara, Kenshiro, Mizuguchi, Hiroko, Sato, Takuya, Taketo, Makoto Mark, Sugiyama, Fumihiro, Ogawa, Takehiko, Kobayashi, Satoru, Ueno, Naoto, Takahashi, Satoru, Takada, Shinji, Yoshida, Shosei, Tokue, Moe, Ikami, Kanako, Mizuno, Seiya, Takagi, Chiyo, Miyagi, Asuka, Takada, Ritsuko, Noda, Chiyo, Kitadate, Yu, Hara, Kenshiro, Mizuguchi, Hiroko, Sato, Takuya, Taketo, Makoto Mark, Sugiyama, Fumihiro, Ogawa, Takehiko, Kobayashi, Satoru, Ueno, Naoto, Takahashi, Satoru, Takada, Shinji, and Yoshida, Shosei

Published
2017

41. Cellular FLIP Inhibits β-Catenin Ubiquitylation and Enhances Wnt Signaling

Author

Naito, Mikihiko, primary, Katayama, Ryohei, additional, Ishioka, Toshiyasu, additional, Suga, Akiko, additional, Takubo, Kohei, additional, Nanjo, Masahiro, additional, Hashimoto, Chizuko, additional, Taira, Masanori, additional, Takada, Shinji, additional, Takada, Ritsuko, additional, Kitagawa, Masatoshi, additional, Matsuzawa, Shu-Ichi, additional, Reed, John C., additional, and Tsuruo, Takashi, additional

Published
2004
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