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818 results on '"Takahara, Shiro"'

2. Delayed peak antibody titers after the second dose of SARS-CoV-2 vaccine in solid organ transplant recipients: Prospective cohort study

Author

Unagami, Kohei, Yoshikawa, Mikiko, Egawa, Hiroto, Ohfuji, Satoko, Natori, Yoichiro, Oki, Rikako, Mori, Tomomi, Hattori, Hidetoshi, Ishiwatari, Ayumi, Kanzawa, Taichi, Shimizu, Tomokazu, Omoto, Kazuya, Inui, Masashi, Masano, Yuuki, Ito, Takashi, Nakajima, Daisuke, Babazono, Tetsuya, Takagi, Toshio, Nunoda, Shinichi, Tomimaru, Yoshito, Imamura, Ryoichi, Miyagawa, Shigeru, Toda, Koichi, Hatano, Etsuro, Date, Hiroshi, Kyakuno, Miyaji, Takahara, Shiro, Yuzawa, Kenji, Tanimine, Naoki, Ohdan, Hideki, Ishida, Hideki, and Hirota, Yoshio

Published
2024
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4. Kinetical analysis of D-alanine upon oral intake

Author

Kimura, Tomonori, primary, Sakai, Shinsuke, additional, Horio, Masaru, additional, Takahara, Shiro, additional, Ishigo, Shoto, additional, Nakane, Maiko, additional, Negishi, Eiichi, additional, Imoto, Hiroshi, additional, Mita, Masashi, additional, Hamase, Kenji, additional, Higa-Maekawa, Yoko, additional, Kakuta, Yoichi, additional, Mizui, Masayuki, additional, and Isaka, Yoshitaka, additional

Published
2024
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6. Serum D-asparagine concentration adjusted for eGFR could serve as a novel screening tool for urothelial carcinoma

Author

Yamamoto, Akinaru, Kawashima, Atsunari, Sakai, Shinsuke, Mita, Masashi, Sassi, Nesrine, Inoguchi, Shunsuke, Horibe, Yuki, Yoshimura, Akihiro, Tani, Masaru, Yutong, Liu, Okuda, Yohei, Oka, Toshiki, Uemura, Toshihiro, Yamamichi, Gaku, Ishizuya, Yu, Hayashi, Takuji, Yamamoto, Yoshiyuki, Kato, Taigo, Hatano, Koji, Kakuta, Yoichi, Imamura, Ryoichi, Takahara, Shiro, Kimura, Tomonori, and Nonomura, Norio

Published
2024
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7. PREFACE

Author

Imamura, Ryoichi, primary, Takahara, Shiro, additional, and Yuzawa, Kenji, additional

Published
2023
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10. Data from Orally Active Vitamin D for Potential Chemoprevention of Posttransplant Malignancy

Author

Obi, Yoshitsugu, primary, Ichimaru, Naotsugu, primary, Hamano, Takayuki, primary, Tomida, Kodo, primary, Matsui, Isao, primary, Fujii, Naohiko, primary, Okumi, Masayoshi, primary, Kaimori, Jun-ya, primary, Yazawa, Koji, primary, Kokado, Yukito, primary, Tsubakihara, Yoshiharu, primary, Nonomura, Norio, primary, Rakugi, Hiromi, primary, Takahara, Shiro, primary, and Isaka, Yoshitaka, primary

Published
2023
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11. Supplementary Table 1 from Orally Active Vitamin D for Potential Chemoprevention of Posttransplant Malignancy

Author

Obi, Yoshitsugu, primary, Ichimaru, Naotsugu, primary, Hamano, Takayuki, primary, Tomida, Kodo, primary, Matsui, Isao, primary, Fujii, Naohiko, primary, Okumi, Masayoshi, primary, Kaimori, Jun-ya, primary, Yazawa, Koji, primary, Kokado, Yukito, primary, Tsubakihara, Yoshiharu, primary, Nonomura, Norio, primary, Rakugi, Hiromi, primary, Takahara, Shiro, primary, and Isaka, Yoshitaka, primary

Published
2023
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12. Comparison of BNT162b2 and mRNA1273 vaccines in solid organ transplant recipients: Post‐Hoc analysis of a Japanese national prospective study.

Author

Yoshikawa, Mikiko, Natori, Yoichiro, Oki, Rikako, Unagami, Kohei, Ohfuji, Satoko, Imamura, Ryoichi, Ishida, Hideki, Takahara, Shiro, Hirota, Yoshio, and Egawa, Hiroto

Subjects
SARS-CoV-2, COVID-19, COVID-19 vaccines, TRANSPLANTATION of organs, tissues, etc., VACCINE immunogenicity
Abstract

The coronavirus disease‐19 (COVID‐19) vaccine efficacy and immunogenicity in the immunocompetent population are well established. However, in solid organ transplant (SOT) recipients, because of their use of immunosuppressive medication, the immunogenicity of these severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccines remains suboptimal. Both BNT162b2 and mRNA1273 have been used for some time, but their immunogenicity has not been directly compared in this immunocompromised patient group. We performed a post‐hoc analysis of a previous prospective cohort study. The inclusion criteria were adult SOT recipients with active grafts at least 1 month after SOT. After giving consent, participants chose to receive either BNT162b2 or mRNA1273 vaccine. Anti‐spike‐protein‐S antibody against SARS‐CoV‐2 was measured. Propensity scores were calculated via logistic regression to transform the probability of having received either BNT162b2 or mRNA1273 vaccine, and a model was developed. We enrolled 623 SOT recipients. In the propensity score‐matched analysis, 100 recipients were selected for BNT162b2 and 100 for mRNA1273. SARS‐CoV‐2 anti‐spike protein antibody positivity with BNT162b2 versus mRNA1273 at 3 weeks after the first dose, 1 month after the second dose, 3 months after the second dose, and 6 months after the second dose were 10% versus 19% (P =.07), 51% versus 58% (P =.30), 74% versus 88% (P =.01), and 78% versus 87% (P =.13), respectively. We conducted a propensity score‐matched comparison of BNT162b2 and mRNA1273 vaccines as the primary series of COVID‐19 vaccines in SOT recipients. We found significantly better immunogenicity with the mRNA1273 vaccine than with BNT162b2. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Identification of Diabetic Nephropathy in Patients Undergoing Kidney Biopsy through Blood and Urinary Profiles of d-Serine

Author

Iwata, Yukimasa, primary, Okushima, Hiroki, additional, Hesaka, Atsushi, additional, Kawamura, Masataka, additional, Imamura, Ryoichi, additional, Takahara, Shiro, additional, Horio, Masaru, additional, Tanaka, Youko, additional, Ikeda, Tatsuhiko, additional, Nakane, Maiko, additional, Mita, Masashi, additional, Hayashi, Terumasa, additional, Isaka, Yoshitaka, additional, and Kimura, Tomonori, additional

Published
2021
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28. Renal transplantations from parents to siblings with autosomal recessive Alport syndrome caused by a rearrangement in an intronic antisense Alu element in the COL4A3 gene led to different outcomes

Author

Kaimori, Jun-ya, Ichimaru, Naotsugu, Isaka, Yoshitaka, Hashimoto, Fusako, Fu, Xuejun, Hashimura, Yuya, Kaito, Hiroshi, Iijima, Kazumoto, Kyo, Masahiro, Namba, Tomoko, Obi, Yoshitsugu, Hatanaka, Masaki, Matsui, Isao, Takabatake, Yoshitsugu, Okumi, Masayoshi, Yazawa, Koji, Nonomura, Norio, Rakugi, Hiromi, and Takahara, Shiro

Published
2013
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37. Correlations of Serum and Urine Levels of Neopterin, IL-8, IL-6, IL-6R, Basic Fetoprotein and Hepatocytes Growth Factor with Acute Rejection in kidney Transplantation

Author

Miki Tsuneharu, Takahara Shiro, and Okuyma Akihiko

Subjects
neopterin, cytokine, hgf, kidney transplantation, Crystallography, QD901-999
Abstract

Levels of serum- and urinary-neopterin and serum-IL-6 and IL-6R of kidney transplant recipients "Were higher in acute rejection episode than in stable condition. IL-8 serum levels had risen prior to clinical diagnosis of acute rejection episode. Serum HGF levels also increased during acute rejection episode to over 1 ng/ml. Serum-neopterin and IL-6R levels were relatively sensitive for the detection of acute rejection episode.

Published
1998
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45. Serum phosphate levels modify the impact of parathyroid hormone levels on renal outcomes in kidney transplant recipients

Author

1000030846382, 0000-0002-5165-291X, Doi, Yohei, Hamano, Takayuki, Ichimaru, Naotsugu, Tomida, Kodo, Obi, Yoshitsugu, Fujii, Naohiko, Yamaguchi, Satoshi, 1000010795173, Oka, Tatsufumi, 1000080756817, Sakaguchi, Yusuke, 1000060456986, 0000-0001-8378-6130, Matsui, Isao, Kaimori, Jun ya, Abe, Toyofumi, Imamura, Ryoichi, Takahara, Shiro, 1000010638026, Tsubakihara, Yoshiharu, 1000030263263, Nonomura, Norio, 1000000379166, Isaka, Yoshitaka, 1000030846382, 0000-0002-5165-291X, Doi, Yohei, Hamano, Takayuki, Ichimaru, Naotsugu, Tomida, Kodo, Obi, Yoshitsugu, Fujii, Naohiko, Yamaguchi, Satoshi, 1000010795173, Oka, Tatsufumi, 1000080756817, Sakaguchi, Yusuke, 1000060456986, 0000-0001-8378-6130, Matsui, Isao, Kaimori, Jun ya, Abe, Toyofumi, Imamura, Ryoichi, Takahara, Shiro, 1000010638026, Tsubakihara, Yoshiharu, 1000030263263, Nonomura, Norio, 1000000379166, and Isaka, Yoshitaka

Abstract

Doi Y., Hamano T., Ichimaru N., et al. Serum phosphate levels modify the impact of parathyroid hormone levels on renal outcomes in kidney transplant recipients. Scientific Reports 10, 13766 (2020); https://doi.org/10.1038/s41598-020-70709-4., Separate assessment of mineral bone disorder (MBD) parameters including calcium, phosphate, parathyroid hormone (PTH), fibroblast growth factor 23 (FGF23), 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D (1,25D) predict renal outcomes in kidney transplant recipients (KTRs), with conflicting results. To date, data simultaneously evaluating these parameters and interwoven relations on renal outcomes are scarce. We conducted a prospective long-term follow-up cohort study included 263 KTRs with grafts functioning at least 1year after transplantation. The outcome was a composite of estimated GFR halving and graft loss. Cox regression analyses were employed to evaluate associations between a panel of six MBD parameters and renal outcomes. The outcome occurred in 98 KTRs during a median follow-up of 10.7years. In a multivariate Cox analysis, intact PTH (iPTH), phosphate, and 1,25D levels were associated with the outcome (hazard ratio, 1.60 per log scale; 95% confidence interval, 1.19–2.14, 1.60 per mg/dL; 1.14–2.23 and 0.82 per 10pg/mL; 0.68–0.99, respectively). Competing risk analysis with death as a competing event yielded a similar result. After stratification into four groups by iPTH and phosphate medians, high risks associated with high iPTH was not observed in KTRs with low phosphate levels (P-interaction < 0.1). Only KTRs not receiving active vitamin D, poor 1,25D status predicted the worse outcome (P-interaction < 0.1). High iPTH, phosphate, and low 1,25D, but not FGF23, levels predicted poor renal outcomes. Simultaneous evaluation of PTH and phosphate levels may provide additional information regarding renal allograft prognosis.

Published
2020

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