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2. Out-of-pocket fertility preservation expenses: data from a Japanese nationwide multicenter survey

Author

Ono, Masanori, Takai, Yasushi, Harada, Miyuki, Horie, Akihito, Dai, Yidan, Kikuchi, Eiji, Miyachi, Mitsuru, Yamamoto, Tetsuya, Fujii, Nobuharu, Kajiyama, Hiroaki, Manabe, Atsushi, Yasuoka, Toshiaki, Katsuragi, Shinji, Mekaru, Keiko, Maezawa, Tadashi, Horage, Yuki, Kataoka, Shinsuke, Nakayama, Robert, Nakajima, Takako Eguchi, Kimura, Fuminori, Shimizu, Chikako, Sugimoto, Kohei, Takae, Seido, Yumura, Yasushi, Nishi, Hirotaka, Furui, Tatsuro, Morishige, Ken-Ichirou, Watanabe, Chie, Osuga, Yutaka, and Suzuki, Nao

Published
2024
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7. Effect of a web-based fertility preservation training program for medical professionals in Japan

Author

Ono, Masanori, Harada, Miyuki, Horie, Akihito, Dai, Yidan, Horiguchi, Itsuko, Kikuchi, Eiji, Kimura, Fuminori, Koizumi, Tomoe, Komeya, Mitsuru, Mizunuma, Naoki, Oseto, Kumiko, Ota, Kuniaki, Shimizu, Chikako, Sugimoto, Kohei, Takae, Seido, Takeuchi, Emi, Nishi, Hirotaka, Yumura, Yasushi, Furui, Tatsuro, Takai, Yasushi, Morishige, Ken-Ichirou, Watanabe, Chie, Osuga, Yutaka, and Suzuki, Nao

Published
2023
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10. Guidance on the need for contraception related to use of pharmaceuticals: the Japan Agency for Medical Research and Development Study Group for providing information on the proper use of pharmaceuticals in patients with reproductive potential

Author

Suzuki, Nao, Takai, Yasushi, Yonemura, Masahito, Negoro, Hiromitsu, Motonaga, Shinya, Fujishiro, Noriko, Nakamura, Eishin, Takae, Seido, Yoshida, Saori, Uesugi, Koji, Ohira, Takashi, Katsura, Aiko, Fujiwara, Michio, Horiguchi, Itsuko, Kosaki, Kenjiro, Onodera, Hiroshi, and Nishiyama, Hiroyuki

Published
2022
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12. Japan Society of Clinical Oncology Clinical Practice Guidelines 2017 for fertility preservation in childhood, adolescent, and young adult cancer patients: part 2

Author

Tozawa, Akiko, Kimura, Fuminori, Takai, Yasushi, Nakajima, Takeshi, Ushijima, Kimio, Kobayashi, Hiroaki, Satoh, Toyomi, Harada, Miyuki, Sugimoto, Kohei, Saji, Shigehira, Shimizu, Chikako, Akiyama, Kyoko, Bando, Hiroko, Kuwahara, Akira, Furui, Tatsuro, Okada, Hiroshi, Kawai, Koji, Shinohara, Nobuo, Nagao, Koichi, Kitajima, Michio, Suenobu, Souichi, Soejima, Toshinori, Miyachi, Mitsuru, Miyoshi, Yoko, Yoneda, Akihiro, Horie, Akihito, Ishida, Yasushi, Usui, Noriko, Kanda, Yoshinobu, Fujii, Nobuharu, Endo, Makoto, Nakayama, Robert, Hoshi, Manabu, Yonemoto, Tsukasa, Kiyotani, Chikako, Okita, Natsuko, Baba, Eishi, Muto, Manabu, Kikuchi, Iwaho, Morishige, Ken-ichirou, Tsugawa, Koichiro, Nishiyama, Hiroyuki, Hosoi, Hajime, Tanimoto, Mitsune, Kawai, Akira, Sugiyama, Kazuhiko, Boku, Narikazu, Yonemura, Masato, Hayashi, Naoko, Aoki, Daisuke, Suzuki, Nao, and Osuga, Yutaka

Published
2022
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13. Japan Society of Clinical Oncology Clinical Practice Guidelines 2017 for fertility preservation in childhood, adolescent, and young adult cancer patients: part 1

Author

Harada, Miyuki, Kimura, Fuminori, Takai, Yasushi, Nakajima, Takeshi, Ushijima, Kimio, Kobayashi, Hiroaki, Satoh, Toyomi, Tozawa, Akiko, Sugimoto, Kohei, Saji, Shigehira, Shimizu, Chikako, Akiyama, Kyoko, Bando, Hiroko, Kuwahara, Akira, Furui, Tatsuro, Okada, Hiroshi, Kawai, Koji, Shinohara, Nobuo, Nagao, Koichi, Kitajima, Michio, Suenobu, Souichi, Soejima, Toshinori, Miyachi, Mitsuru, Miyoshi, Yoko, Yoneda, Akihiro, Horie, Akihito, Ishida, Yasushi, Usui, Noriko, Kanda, Yoshinobu, Fujii, Nobuharu, Endo, Makoto, Nakayama, Robert, Hoshi, Manabu, Yonemoto, Tsukasa, Kiyotani, Chikako, Okita, Natsuko, Baba, Eishi, Muto, Manabu, Kikuchi, Iwaho, Morishige, Ken-ichirou, Tsugawa, Koichiro, Nishiyama, Hiroyuki, Hosoi, Hajime, Tanimoto, Mitsune, Kawai, Akira, Sugiyama, Kazuhiko, Boku, Narikazu, Yonemura, Masato, Hayashi, Naoko, Aoki, Daisuke, Osuga, Yutaka, and Suzuki, Nao

Published
2022
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14. Indications for fertility preservation not included in the 2017 Japan Society of Clinical Oncology Guideline for Fertility Preservation in Pediatric, Adolescent, and Young Adult Patients treated with gonadal toxicity, including benign diseases

Author

Ono, Masanori, Matsumoto, Kimikazu, Boku, Narikazu, Fujii, Nobuharu, Tsuchida, Yumi, Furui, Tatsuro, Harada, Miyuki, Kanda, Yoshinobu, Kawai, Akira, Miyachi, Mitsuru, Murashima, Atsuko, Nakayama, Robert, Nishiyama, Hiroyuki, Shimizu, Chikako, Sugiyama, Kazuhiko, Takai, Yasushi, Fujio, Keishi, Morishige, Ken-Ichirou, Osuga, Yutaka, and Suzuki, Nao

Published
2022
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18. Correction to: Japan Society of Clinical Oncology Clinical Practice Guidelines 2017 for fertility preservation in childhood, adolescent, and young adult cancer patients: part 2

Author

Tozawa, Akiko, Kimura, Fuminori, Takai, Yasushi, Nakajima, Takeshi, Ushijima, Kimio, Kobayashi, Hiroaki, Satoh, Toyomi, Harada, Miyuki, Sugimoto, Kohei, Saji, Shigehira, Shimizu, Chikako, Akiyama, Kyoko, Bando, Hiroko, Kuwahara, Akira, Furui, Tatsuro, Okada, Hiroshi, Kawai, Koji, Shinohara, Nobuo, Nagao, Koichi, Kitajima, Michio, Suenobu, Souichi, Soejima, Toshinori, Miyachi, Mitsuru, Miyoshi, Yoko, Yoneda, Akihiro, Horie, Akihito, Ishida, Yasushi, Usui, Noriko, Kanda, Yoshinobu, Fujii, Nobuharu, Endo, Makoto, Nakayama, Robert, Hoshi, Manabu, Yonemoto, Tsukasa, Kiyotani, Chikako, Okita, Natsuko, Baba, Eishi, Muto, Manabu, Kikuchi, Iwaho, Morishige, Ken-ichirou, Tsugawa, Koichiro, Nishiyama, Hiroyuki, Hosoi, Hajime, Tanimoto, Mitsune, Kawai, Akira, Sugiyama, Kazuhiko, Boku, Narikazu, Yonemura, Masato, Hayashi, Naoko, Aoki, Daisuke, Suzuki, Nao, and Osuga, Yutaka

Published
2022
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19. A study on the efficacy and safety of long‐term adjusted low‐dose gonadotropin‐releasing hormone agonist therapy for uterine fibroids and adenomyosis.

Author

Kashiwabara, Soichiro, Yabe, Shinichiro, Samejima, Koki, Narita, Tatsuya, Itaya, Yukiko, Era, Sumiko, Matsunaga, Shigetaka, Nagai, Tomonori, Kikuchi, Akihiko, and Takai, Yasushi

Subjects
CONSERVATIVE treatment, PATIENT safety, BONE density, SCIENTIFIC observation, HEMOGLOBINS, RETROSPECTIVE studies, DESCRIPTIVE statistics, TREATMENT duration, UTERINE fibroids, ENDOMETRIOSIS, ESTRADIOL, GONADOTROPIN releasing hormone, DRUG efficacy, MEDICAL records, ACQUISITION of data, LUMBAR vertebrae, FEMUR, MENSTRUATION
Abstract

Aim: To investigate the efficacy and safety of long‐term adjusted low‐dose gonadotropin‐releasing hormone agonist therapy (GnRH agonist drawback therapy) with nafarelin acetate in patients with uterine fibroids and/or adenomyosis with menstrual symptoms. Methods: This single‐center, retrospective, observational study initially included 118 patients with uterine fibroids and/or adenomyosis with menstrual symptoms who had received GnRH agonist (nafarelin acetate) drawback therapy for at least 7 months between 2010 and 2020. Blood hemoglobin level, maximum fibroid diameter, area of the corpus uteri, blood estradiol level, daily dosage of nafarelin acetate, and bone density in the lumbar spine and femoral neck were assessed before and after the treatment initiation. Results: The median treatment period was 28 months. Menstruation had ceased in all patients. The median hemoglobin level significantly increased from 8.6 to 13.2 g/dL before treatment and at 12 months after the treatment initiation in patients with fibroids and from 8.8 to 13.3 g/dL in patients with adenomyosis, respectively. Although the treatment did not exert a significant shrinking effect on the fibroids and adenomyosis, an increase in their size was not observed in any patient. The initial dose of nafarelin acetate was 400 μg/day and was lowered to 130 μg/day at 12 months. Only 29 patients (25%) had an estradiol level <30 pg/mL. The average rate of bone density change over 6 months was −1.23% in the lumbar spine and −1.12% in the femoral neck in patients with fibroids and −1.06% in the lumbar spine and −0.14% in the femoral neck in patients with adenomyosis, which were lower than the previously reported rates. Conclusions: GnRH agonist drawback therapy was found to be useful for the long‐term conservative treatment of uterine fibroids and adenomyosis. The treatment was safely and inexpensively performed with few adverse events. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Diagnosis of abnormal uterine bleeding based on the FIGO classification: A systematic review and expert opinions.

Author

Kitahara, Yoshikazu, Hiraike, Osamu, Ishikawa, Hiroshi, Kugu, Koji, Takai, Yasushi, Yoshino, Osamu, Ono, Masanori, Maekawa, Ryo, Ota, Ikuko, and Iwase, Akira

Subjects
DIFFERENTIAL diagnosis, SYSTEMATIC reviews, MEDLINE, UTERINE hemorrhage, EVIDENCE-based medicine, ONLINE information services, ATTRIBUTION (Social psychology)
Abstract

Aim: To present evidence‐ and consensus‐based recommendations for the diagnosis abnormal uterine bleeding. Methods: A literature search for the diagnosis of abnormal uterine bleeding was systematically conducted in PubMed from its inception to May 2024 to identify meta‐analyses, reviews, randomized controlled trials, and clinical trials, followed by an additional systematic search using keywords. Based on this evidence, an expert panel developed background, clinical, and future research questions. Results: Based on a systematic search and the collected evidence, we developed five background questions, three clinical questions, and one future research question, with recommendations and/or statements. Evidence and recommendations are provided for clinical questions. Additionally, we developed a flowchart for diagnosis showing the steps of the examinations to be performed. Conclusion: The flowchart and nine recommendations/statements specify an efficient diagnostic procedure to differentiate abnormal causative diseases of uterine bleeding optimized for actual Japanese situations. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Correction to: Indications for fertility preservation not included in the 2017 Japan Society of Clinical Oncology Guideline for Fertility Preservation in Pediatric, Adolescent, and Young Adult Patients treated with gonadal toxicity, including benign diseases

Author

Ono, Masanori, Matsumoto, Kimikazu, Boku, Narikazu, Fujii, Nobuharu, Tsuchida, Yumi, Furui, Tatsuro, Harada, Miyuki, Kanda, Yoshinobu, Kawai, Akira, Miyachi, Mitsuru, Murashima, Atsuko, Nakayama, Robert, Nishiyama, Hiroyuki, Shimizu, Chikako, Sugiyama, Kazuhiko, Takai, Yasushi, Fujio, Keishi, Morishige, Ken-Ichirou, Osuga, Yutaka, and Suzuki, Nao

Published
2022
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24. Patient-Centric Approach to Personalized Electronic Medical Records via QR code in Japan (Preprint)

Author

Izumida, Yoshihiko, primary, Omura, Takashi, additional, Fujiwara, Masahiro, additional, Nukaya, Shoko, additional, Yoneyama, Akio, additional, Shinichiro, Yabe, additional, Noguchi, Rika, additional, Nakayama, Shima, additional, Muraoka, Wataru, additional, Okuno, Yuki, additional, Miyashita, Sho, additional, Ishihara, Yurika, additional, Moriwaki, Yuto, additional, Otani, Ryoji, additional, Adachi, Junichiro, additional, Tanabe, Kenichiro, additional, Yamano, Yoshihisa, additional, Takai, Yasushi, additional, and Honjo, Masaru, additional

Published
2024
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30. A nationwide survey of diagnostic procedures for abnormal uterine bleeding in Japan.

Author

Kitahara, Yoshikazu, Hiraike, Osamu, Ishikawa, Hiroshi, Kugu, Koji, Takai, Yasushi, Yoshino, Osamu, Ono, Masanori, Maekawa, Ryo, Ota, Ikuko, and Iwase, Akira

Subjects
PELVIC radiography, CYTOLOGY, BIOPSY, HYSTEROSALPINGOGRAPHY, ENDOMETRIUM, MAGNETIC resonance imaging, DESCRIPTIVE statistics, SURVEYS, UTERINE hemorrhage, MENSTRUATION disorders, DATA analysis software, AMENORRHEA
Abstract

Aim: To clarify the diagnostic process of the causative disease of abnormal uterine bleeding (AUB) in Japan according to the International Federation of Gynecology and Obstetrics AUB diagnostic system. Methods: Patients diagnosed with AUB were included in a nationwide survey of AUB conducted during any 2‐week period between December 2019 and January 2020. The second survey included information on patient background, AUB symptoms, examinations for diagnosing AUB, the order in which they were performed, and the causative diseases of AUB. Results: Correspondence analysis showed an association between hormonal testing, hysterosalpingography, and magnetic resonance imaging (MRI) in patients with amenorrhea, and heavy menstrual bleeding was strongly correlated with various examinations, such as coagulation tests, pelvic MRI, and endometrial cytology or biopsy. The results also indicated that each AUB causative disease can be diagnosed based on a specific examination profile. Conclusion: We clarified the process of diagnosing the causative disease of AUB in our country and determined that it was mainly diagnosed by imaging and pathological examination in cases of structural disease. The high rate of AUB‐E and the low rate of AUB‐C are possibly associated with specific examination trends in Japan. The results of this study will be useful for the development of a standard protocol for AUB diagnosis in our country. [ABSTRACT FROM AUTHOR]

Published
2024
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37. A multicentral prospective cohort trial of a pharmacist-led nutritional intervention on serum potassium levels in outpatients with chronic kidney disease: The MieYaku-Chronic Kidney Disease project.

Author

Asai, Yuki, Muramatsu, Asami, Kobayashi, Tatsuya, Takasaki, Ikuhiro, Murasaka, Toshiki, Izukawa, Ai, Miyada, Kahori, Okazaki, Takahiro, Yanagawa, Tatsuki, Abe, Yasuharu, Takai, Yasushi, and Iwamoto, Takuya

Subjects
CHRONIC kidney failure, KIDNEY diseases, POTASSIUM, COMMUNITY-based programs, GLOMERULAR filtration rate
Abstract

Although dietary potassium restriction is an acceptable approach to hyperkalemia prevention, it may be insufficient for outpatients with chronic kidney disease (CKD). Most outpatients with CKD use community pharmacies owing to the free access scheme in Japan. The MieYaku-CKD project included a community pharmacist-led nutritional intervention for dietary potassium restriction, with the goal of determining its efficacy for patients' awareness of potassium restriction and serum potassium levels in outpatients with CKD. This was a five-community pharmacy multicenter prospective cohort study with an open-label, before-and-after comparison design. Eligible patients (n = 25) with an estimated glomerular filtration rate (eGFR) < 45 mL/min/1.73 m2 received nutritional guidance from community pharmacists. The primary outcome was a change in serum potassium levels at 12 weeks post-intervention. The eligible patients' knowledge, awareness, and implementation of potassium restriction were evaluated using a questionnaire. The median value of serum potassium was significantly reduced from 4.7 mEq/L before to 4.4 mEq/L after the intervention [p < 0.001, 95% confidence interval (CI): 0.156–0.500], with no changes in eGFR (p = 0.563, 95% CI: -2.427–2.555) and blood urine nitrogen/serum creatinine ratio (p = 0.904, 95% CI: -1.793–1.214). The value of serum potassium had a tendency of attenuation from 5.3 to 4.6 mEq/L (p = 0.046, 95% CI: 0.272–1.114) in the eGFR < 30 mL/min/1.73 m2 group. A questionnaire revealed that after the intervention, knowledge and attitudes regarding dietary potassium restriction were much greater than before, suggesting that the decrease in serum potassium levels may be related to this nutritional guidance. Our findings indicate that implementing a dietary potassium restriction guidance program in community pharmacies is feasible and may result in lower serum potassium levels in outpatients with CKD. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Current Status and Issues of the Japan Oncofertility Registry

Author

Shigematsu, Kosuke, primary, Shimizu, Chikako, additional, Furui, Tatsuro, additional, Kataoka, Shinsuke, additional, Kawai, Kiyotaka, additional, Kishida, Toru, additional, Kuwahara, Akira, additional, Maeda, Naoko, additional, Makino, Azumi, additional, Mizunuma, Naoki, additional, Morishige, Ken-ichirou, additional, Nakajima, Takako Eguchi, additional, Ota, Kuniaki, additional, Ono, Masanori, additional, Shiga, Naomi, additional, Tada, Yuma, additional, Takae, Seido, additional, Tamura, Nobuko, additional, Watanabe, Chie, additional, Yumura, Yasushi, additional, Suzuki, Nao, additional, and Takai, Yasushi, additional

Published
2023
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45. Oncofertility‐related psycho‐educational therapy for young adult patients with breast cancer and their partners: Randomized controlled trial

Author

Koizumi, Tomoe, primary, Sugishita, Yodo, additional, Suzuki‐Takahashi, Yuki, additional, Nara, Kazuko, additional, Miyagawa, Tomoko, additional, Nakajima, Misako, additional, Sugimoto, Kouhei, additional, Futamura, Manabu, additional, Furui, Tatsuro, additional, Takai, Yasushi, additional, Matsumoto, Hiroshi, additional, Yamauchi, Hideko, additional, Ohno, Shinji, additional, Kataoka, Akemi, additional, Kawai, Kiyotaka, additional, Fukuma, Eisuke, additional, Nogi, Hiroko, additional, Tsugawa, Koichiro, additional, and Suzuki, Nao, additional

Published
2023
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48. Investigation of an efficient method of oocyte retrieval by dual stimulation for patients with cancer

Author

Takeuchi, Hiroki, primary, Maezawa, Tadashi, additional, Hagiwara, Katsuyuki, additional, Horage, Yuki, additional, Hanada, Tetsuro, additional, Haipeng, Huang, additional, Sakamoto, Mito, additional, Nishioka, Mikiko, additional, Takayama, Erina, additional, Terada, Kento, additional, Kondo, Eiji, additional, Takai, Yasushi, additional, Suzuki, Nao, additional, and Ikeda, Tomoaki, additional

Published
2023
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50. A Nationwide Survey Aimed at Establishing an Appropriate Long-Term Storage and Management System for Fertility Preserving Specimens in Japan

Author

Maezawa, Tadashi, primary, Takae, Seido, additional, Takeuchi, Hiroki, additional, Takenaka, Motoki, additional, Ota, Kuniaki, additional, Horie, Akihito, additional, Suzuki, Tatsuya, additional, Takai, Yasushi, additional, Kimura, Fuminori, additional, Furui, Tatsuro, additional, Ikeda, Tomoaki, additional, and Suzuki, Nao, additional

Published
2022
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