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15. Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease

Author

Torres VE, Chapman AB, Devuyst O, Gansevoort RT, Grantham JJ, Higashihara E, Perrone RD, Krasa HB, Ouyang J, Czerwiec FS, Tempo team, Gross P, Schulze B, Bichet D, Chauveau D, Peeters P, Voiculescu M, Manunta P, Tuazon J, Watnick T, Goral S, Horie S, Nutahara K, Torres V, Chapman A, Gansevoort R, Perrone R, Czerwiec F, Goldstein S, Cowley B, Fukagawa M, Torra R, Wei LJ, Cook T, Toto R, Agarwal R, August P, Bakris G, Beddhu S, Corwin H, Ruilope L, Rosa-Diez G, De La Fuente J, Martin R, Massari P, Novoa P, Rial M, Wasserman A, Faull R, Fraser I, Johnson D, Pedagagos E, Lian M, Pollock C, Cooper B, Rangan G, Russ G, McDonald S, Thomas M, Khoo D, Walker R, Pirson Y, Laecke V, Van der Niepen P, Sennesael J, Barre P, Alam A, Soroka S, Dieperink H, Strandgaard S, Petersen L, Berthoux F, Canaud B, Gontiers-Picard A, Huart A, Combe C, Delmas Y, Dussol B, Laville M, Guebre-Egziabher F, Mignon F, Michel C, Rieu P, Noel N, Ryckelynck J, Lobbedez T, Dellanna F, Kleophas W, Feldkamp T, Witzke O, Nurnberger J, Zeltner R, Walz G, Zeier M, Sommerer C, Bianchi S, Capasso G, Miranda N, Magistroni R, Bracale M, Remuzzi G, Rota S, Villa G, Tilocca P, Asahi K, Kato T, Endo M, Umezono T, Fujigaki Y, Kato A, Fukatsu A, Hasegawa H, Tayama Y, Hasegawa M, Hosoya T, Hanaoka K, Iehara N, Iino Y, Tsuruoka S, Imai E, Isaka Y, Ishimura E, Ito S, Sato H, Kamata K, Sakamoto H, Kamura K, Kusano E, Muto S, Kuwahara M, Matsubara A, Yorioka N, Mochizuki T, Narita I, Naya Y, Nihei N, Yukio N, Nishio S, Nitta K, Tsuchiya K, Okamura M, Sasaki S, Rai T, Seta K, Sugawara A, Shibazaki S, Sugiyama S, Tabei K, Takaichi K, Tomita K, Kitamura K, Tsukamoto Y, Tsuruya K, Nakano T, Ubara Y, Watanabe T, Yamamoto T, Yoshida K, Ishii D, Yuzawa Y, Meijer E, Vervloet M, Ciechanowski K, Wisniewska M, Gutowska-Jablonska M, Marcinkowska-Królewicz M, Klatko W, Wiśniewski T, Klinger M, Krajewska M, Ksiazek A, Orłowska G, Malecki R, Gontarek-Kacprzak J, Nowicki M, Makówka A, Rutkowski B, Wołyniec W, Rydzewski A, Sulowicz W, Jasik P, Covic A, Volovat C, Mircescu G, Petrescu L, Bobeica R, Barbarash O, Chesnokova L, Borovoy S, Demina L, Shostka G, Idovu M, Tkalich L, Geynits O, Tomilina N, Foggensteiner L, Holt S, Kingswood J, Lambie S, Peel R, MacDougall I, Tucker B, MacPhee I, Maxwell A, Brown H, Mikhail A, Bastin L, Turner N, Neary J, Wheeler D, Maxwell P, Wilkie M, Ong A, Zehnder D, Aldridge N, Adler S, Klein M, Battle D, Bennett W, Berger B, Dell K, Blumenfeld J, Donahue S, Bolin P, Browder R, Perry A, Oskoui F, Culpepper M, Dahl N, Edelstein C, Clegg L, Fischer D, Kaplan M, Kaveh K, Pankhaniya R, Koren M, Mansur K, Lafayette R, Lamar W, Lee J, Mahnensmith R, Nachman P, Mottl A, Miskulin D, Petersen J, Radhakrishnan J, Roppolo M, Basireddy M, Rosner M, Bolton W, Schulman G, Steed L, Steinman T, Hogan M, Venuto R, Turban S, Winklhofer F., Cardiovascular Centre (CVC), Groningen Kidney Center (GKC), Torres, Ve, Chapman, Ab, Devuyst, O, Gansevoort, Rt, Grantham, Jj, Higashihara, E, Perrone, Rd, Krasa, Hb, Ouyang, J, Czerwiec, F, Tempo, Team, Gross, P, Schulze, B, Bichet, D, Chauveau, D, Peeters, P, Voiculescu, M, Manunta, P, Tuazon, J, Watnick, T, Goral, S, Horie, S, Nutahara, K, Torres, V, Chapman, A, Gansevoort, R, Perrone, R, Goldstein, S, Cowley, B, Fukagawa, M, Torra, R, Wei, Lj, Cook, T, Toto, R, Agarwal, R, August, P, Bakris, G, Beddhu, S, Corwin, H, Ruilope, L, Rosa-Diez, G, De La Fuente, J, Martin, R, Massari, P, Novoa, P, Rial, M, Wasserman, A, Faull, R, Fraser, I, Johnson, D, Pedagagos, E, Lian, M, Pollock, C, Cooper, B, Rangan, G, Russ, G, Mcdonald, S, Thomas, M, Khoo, D, Walker, R, Pirson, Y, Laecke, V, Van der Niepen, P, Sennesael, J, Barre, P, Alam, A, Soroka, S, Dieperink, H, Strandgaard, S, Petersen, L, Berthoux, F, Canaud, B, Gontiers-Picard, A, Huart, A, Combe, C, Delmas, Y, Dussol, B, Laville, M, Guebre-Egziabher, F, Mignon, F, Michel, C, Rieu, P, Noel, N, Ryckelynck, J, Lobbedez, T, Dellanna, F, Kleophas, W, Feldkamp, T, Witzke, O, Nurnberger, J, Zeltner, R, Walz, G, Zeier, M, Sommerer, C, Bianchi, S, Capasso, G, Miranda, N, Magistroni, R, Bracale, M, Remuzzi, G, Rota, S, Villa, G, Tilocca, P, Asahi, K, Kato, T, Endo, M, Umezono, T, Fujigaki, Y, Kato, A, Fukatsu, A, Hasegawa, H, Tayama, Y, Hasegawa, M, Hosoya, T, Hanaoka, K, Iehara, N, Iino, Y, Tsuruoka, S, Imai, E, Isaka, Y, Ishimura, E, Ito, S, Sato, H, Kamata, K, Sakamoto, H, Kamura, K, Kusano, E, Muto, S, Kuwahara, M, Matsubara, A, Yorioka, N, Mochizuki, T, Narita, I, Naya, Y, Nihei, N, Yukio, N, Nishio, S, Nitta, K, Tsuchiya, K, Okamura, M, Sasaki, S, Rai, T, Seta, K, Sugawara, A, Shibazaki, S, Sugiyama, S, Tabei, K, Takaichi, K, Tomita, K, Kitamura, K, Tsukamoto, Y, Tsuruya, K, Nakano, T, Ubara, Y, Watanabe, T, Yamamoto, T, Yoshida, K, Ishii, D, Yuzawa, Y, Meijer, E, Vervloet, M, Ciechanowski, K, Wisniewska, M, Gutowska-Jablonska, M, Marcinkowska-Królewicz, M, Klatko, W, Wiśniewski, T, Klinger, M, Krajewska, M, Ksiazek, A, Orłowska, G, Malecki, R, Gontarek-Kacprzak, J, Nowicki, M, Makówka, A, Rutkowski, B, Wołyniec, W, Rydzewski, A, Sulowicz, W, Jasik, P, Covic, A, Volovat, C, Mircescu, G, Petrescu, L, Bobeica, R, Barbarash, O, Chesnokova, L, Borovoy, S, Demina, L, Shostka, G, Idovu, M, Tkalich, L, Geynits, O, Tomilina, N, Foggensteiner, L, Holt, S, Kingswood, J, Lambie, S, Peel, R, Macdougall, I, Tucker, B, Macphee, I, Maxwell, A, Brown, H, Mikhail, A, Bastin, L, Turner, N, Neary, J, Wheeler, D, Maxwell, P, Wilkie, M, Ong, A, Zehnder, D, Aldridge, N, Adler, S, Klein, M, Battle, D, Bennett, W, Berger, B, Dell, K, Blumenfeld, J, Donahue, S, Bolin, P, Browder, R, Perry, A, Oskoui, F, Culpepper, M, Dahl, N, Edelstein, C, Clegg, L, Fischer, D, Kaplan, M, Kaveh, K, Pankhaniya, R, Koren, M, Mansur, K, Lafayette, R, Lamar, W, Lee, J, Mahnensmith, R, Nachman, P, Mottl, A, Miskulin, D, Petersen, J, Radhakrishnan, J, Roppolo, M, Basireddy, M, Rosner, M, Bolton, W, Schulman, G, Steed, L, Steinman, T, Hogan, M, Venuto, R, Turban, S, Winklhofer, F., University of Zurich, Torres, Vicente E, Feldkamp, Thorsten (Beitragende*r), and Witzke, Oliver (Beitragende*r)

Subjects
Male, Tolvaptan, Medizin, 2700 General Medicine, SIROLIMUS, Kidney, V2 RECEPTOR ANTAGONIST, 10052 Institute of Physiology, Aquaretic, VASOPRESSIN V-2-RECEPTOR ANTAGONIST, Polycystic Kidney, 10035 Clinic for Nephrology, Medicine (all), General Medicine, Organ Size, Middle Aged, Adolescent, Adult, Benzazepines, Double-Blind Method, Female, Glomerular Filtration Rate, Humans, Polycystic Kidney, Autosomal Dominant, Sodium, Young Adult, Antidiuretic Hormone Receptor Antagonists, LONG-ACTING SOMATOSTATIN, Autosomal Dominant, 10076 Center for Integrative Human Physiology, OPC-41061, medicine.symptom, medicine.drug, medicine.medical_specialty, RENAL-FUNCTION, CYST GROWTH, Autosomal dominant polycystic kidney disease, Urology, Renal function, Kidney Volume, 610 Medicine & health, Placebo, Article, VOLUME PROGRESSION, Cystic kidney disease, Internal medicine, medicine, HYPONATREMIA, business.industry, urogenital system, ORAL TOLVAPTAN, medicine.disease, Endocrinology, Albuminuria, 570 Life sciences, biology, business
Abstract

BACKGROUND: The course of autosomal dominant polycystic kidney disease (ADPKD) is often associated with pain, hypertension, and kidney failure. Preclinical studies indicated that vasopressin V 2 -receptor antagonists inhibit cyst growth and slow the decline of kidney function. METHODS: In this phase 3, multicenter, double-blind, placebo-controlled, 3-year trial, we randomly assigned 1445 patients, 18 to 50 years of age, who had ADPKD with a total kidney volume of 750 ml or more and an estimated creatinine clearance of 60 ml per minute or more, in a 2:1 ratio to receive tolvaptan, a V 2 -receptor antagonist, at the highest of three twice-daily dose regimens that the patient found tolerable, or placebo. The primary outcome was the annual rate of change in the total kidney volume. Sequential secondary end points included a composite of time to clinical progression (defined as worsening kidney function, kidney pain, hypertension, and albuminuria) and rate of kidney-function decline. RESULTS: Over a 3-year period, the increase in total kidney volume in the tolvaptan group was 2.8% per year (95% confidence interval [CI], 2.5 to 3.1), versus 5.5% per year in the placebo group (95% CI, 5.1 to 6.0; P

Published
2012

16. Developing an HbA1c-based equation to estimate blood glucose in maintenance hemodialysis patients

Author

Hoshino, J, Molnar, MZ, Yamagata, K, Ubara, Y, Takaichi, K, Kovesdy, CP, and Kalantar-Zadeh, K

Abstract

OBJECTIVE-Hemoglobin A1c(HbA1c) has been widely used as a clinically important assessment tool for outcome analyses related to glycemic control. However, because of special conditions in dialysis patients, including the uremic milieu, there is no HbA1cblood glucose (BG) equation specific for patients on dialysis. In this study, we sought to develop HbA1c-BG equation models for hemodialysis patients. RESEARCH DESIGN AND METHODS-We examined associations between HbA1cand random serum BG over time in a contemporary cohort of diabetic patients with hemodialysis treated in DaVita dialysis clinics. We identified 11,986 patients (63±12 years old and 49%male) with 69,764 paired measurements of HbA1cand BG over the course of 5 years (2001-2006). Bootstrapping method was used to estimate average BG and corresponding HbA1clevels. The association was adjusted by patient factors using linear regression. RESULTSdLinear regression analyses yielded the following three regression equations: BG = 59.2 + 29.4 × HbA1c2 20.8 × Alb (R2= 0.483); BG = 104.8 + 29.7 × HbA1c2 18.4 × Alb 2 4.7 × Hb (R2= 0.486); and BG = 82.9 + 30.7 × HbA1c2 16.5 × Alb 2 5.4 × Hb + 0.3 × age + race (R2= 0.491). All our models showed stronger association than previous equation models (R2= 0.468 in the Diabetes Control and Complications Trial and A1c-Derived Average Glucose equations). CONCLUSIONS-The association between HbA1cand BG in hemodialysis patients is different than that of patients with normal kidney function. Our analysis suggests that equations including serum albumin or hemoglobin are better for hemodialysis patients. © 2013 by the American Diabetes Association.

Published
2013
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19. Impact of tubulointerstitial lesions on anaemia in patients with biopsy‐proven diabetic nephropathy

Author

Mise, K., primary, Hoshino, J., additional, Ueno, T., additional, Imafuku, A., additional, Kawada, M., additional, Sumida, K., additional, Hiramatsu, R., additional, Hasegawa, E., additional, Yamanouchi, M., additional, Hayami, N., additional, Suwabe, T., additional, Sawa, N., additional, Fujii, T., additional, Hara, S., additional, Ohashi, K., additional, Takaichi, K., additional, and Ubara, Y., additional

Published
2014
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21. DIALYSIS BONE DISEASE

Author

Fusaro, M., primary, Giannini, S., additional, Miozzo, D., additional, Noale, M., additional, Tripepi, G., additional, Plebani, M., additional, Zaninotto, M., additional, Piccoli, A., additional, Vilei, M. T., additional, Cristofaro, R., additional, Gallieni, M., additional, Hamamoto, K., additional, Inaba, M., additional, Okuno, S., additional, Imanishi, Y., additional, Ishimura, E., additional, Yamakawa, T., additional, Shoji, S., additional, Rothe, H. M., additional, Eller, P., additional, Mayer, G., additional, Ketteler, M., additional, Kramar, R., additional, Shaheen, F., additional, Al Rukhaimi, M., additional, Alsahow, A., additional, Al-Ali, F., additional, Al Salmi, I., additional, Al Ghareeb, S., additional, Wang, M., additional, Bieber, B., additional, Robinson, B. M., additional, Pisoni, R. L., additional, Waniewski, J., additional, Debowska, M., additional, Wojcik-Zaluska, A., additional, Ksiazek, A., additional, Zaluska, W., additional, De Broe, M. E., additional, Wilson, R. J., additional, Copley, J. B., additional, Hiramtasu, R., additional, Ubara, Y., additional, Hoshino, J., additional, Takaichi, K., additional, Ghalli, F. G., additional, Ibakkanavar, R., additional, Chess, J., additional, Roberts, G., additional, Riley, S., additional, Oliveira, A. S. A., additional, Carvalho, C. J. B., additional, Oliveira, C. B. L., additional, Pessoa, C. T. B. C., additional, Leao, R. A. S., additional, Gueiros, J. E. B., additional, Gueiros, A. P. S., additional, Okano, K., additional, Tsuruta, Y., additional, Hibi, A., additional, Tsukada, M., additional, Miwa, N., additional, Kimata, N., additional, Tsuchiya, K., additional, Akiba, T., additional, Nitta, K., additional, Mizobuchi, M., additional, Ogata, H., additional, Hosaka, N., additional, Sanada, D., additional, Arai, N., additional, Koiwa, F., additional, Kinugasa, E., additional, Shibata, T., additional, Akizawa, T., additional, Delanaye, P., additional, Krzesinski, J.-M., additional, Warling, X., additional, Moonen, M., additional, Smelten, N., additional, Medart, L., additional, Pottel, H., additional, Cavalier, E., additional, Souberbielle, J.-C., additional, Gadisseur, R., additional, Dubois, B. E., additional, Matias, P., additional, Jorge, C., additional, Mendes, M., additional, Azevedo, A., additional, Navarro, D., additional, Ferreira, C., additional, Amaral, T., additional, Aires, I., additional, Gil, C., additional, Ferreira, A., additional, Kikuchi, H., additional, Shimada, H., additional, Karasawa, R., additional, Suzuki, M., additional, An, W. S., additional, Lee, S. M., additional, Oh, Y. J., additional, Son, Y. K., additional, De Paola, L., additional, Lombardi, G., additional, Panzino, M. T., additional, Lombardi, L., additional, Reichel, H., additional, Hahn, K.-M., additional, Kohnle, M., additional, Guggenberger, C., additional, Delanna, F., additional, Sasaki, N., additional, Tsunoda, M., additional, Ikee, R., additional, Hashimoto, N., additional, Sola, L., additional, Leyun, M. N., additional, Diaz, J. C., additional, Sehabiague, C., additional, Gonzalez, S., additional, Alallon, W., additional, Bourbeau, K., additional, Lajoie, C., additional, Macway, F., additional, Fujii, T., additional, Suzuki, S., additional, Shinozaki, M., additional, Tanaka, H., additional, Klingele, M., additional, Seiler, S., additional, Poppleton, A., additional, Lepper, P., additional, Fliser, D., additional, Seidel, R., additional, Lun, L., additional, Liu, D., additional, Li, X., additional, Wei, X., additional, Miao, J., additional, Gao, Z., additional, Hu, R., additional, Gros, B., additional, Galan, A., additional, Gonzalez-Parra, E., additional, Herrero, J. A., additional, Echave, M., additional, Vegter, S., additional, Tolley, K., additional, Oyaguez, I., additional, Gutzwiller, F. S., additional, Braunhofer, P. G., additional, Szucs, T. D., additional, Schwenkglenks, M., additional, Yilmaz, V. T., additional, Ozdem, S., additional, Donmez, L., additional, Kocak, H., additional, Dinckan, A., additional, Cetinkaya, R., additional, Suleymanlar, G., additional, and Ersoy, F. F., additional

Published
2014
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22. PRIMARY AND SECONDARY GLOMERULONEPHRITIDES 2

Author

Monova, D., primary, Monov, S., additional, Todorov, T., additional, Soderberg, D., additional, Kurz, T., additional, Weiner, M., additional, Eriksson, P., additional, Segelmark, M., additional, Jakuszko, K., additional, Sebastian, A., additional, Bednarz, Z., additional, Krajewska, M., additional, Wiland, P., additional, Madziarska, K., additional, Weyde, W., additional, Klinger, M., additional, Naidoo, J., additional, Wearne, N., additional, Jones, E., additional, Swanepoel, C., additional, Rayner, B., additional, Okpechi, I., additional, Endo, N., additional, Tsuboi, N., additional, Furuhashi, K., additional, Matsuo, S., additional, Maruyama, S., additional, Clerte, M., additional, Levi, C., additional, Touzot, M., additional, Fakhouri, F., additional, Monge, C., additional, Lebas, C., additional, Abboud, I., additional, Huart, A., additional, Durieux, P., additional, Charlin, E., additional, Thervet, E., additional, Karras, A., additional, Smykal-Jankowiak, K., additional, Niemir, Z. I., additional, Polcyn-Adamczak, M., additional, Whatmough, S., additional, Sweeney, N., additional, Fernandez, S., additional, Hussain, M., additional, Dhaygude, A., additional, Gniewek, K., additional, Manenti, L., additional, Urban, M. L., additional, Vaglio, A., additional, Gintoli, E., additional, Galletti, M., additional, Buzio, C., additional, Monova, D., additional, Argirova, T., additional, Wong, I., additional, Ibrahim, F. H., additional, Goh, B. L., additional, Lim, T. S., additional, Chan, M. W., additional, Hiramtasu, R., additional, Ubara, Y., additional, Hoshino, J., additional, Takaichi, K., additional, Ghafoor, V., additional, Sahay, M., additional, Soma, J., additional, Nakaya, I., additional, Sasaki, N., additional, Yoshikawa, K., additional, Sato, H., additional, Kaminskyy, V., additional, ZAbi Ska, M., additional, Ko Cielska-Kasprzak, K., additional, Niemir, Z., additional, Wozniczka, K., additional, Swierzko, A., additional, Cedzynski, M., additional, Sokolowska, A., additional, Szala, A., additional, Arjunan, A., additional, Mikhail, A., additional, Shrivastava, R., additional, Parker, C., additional, Aithal, S., additional, Gursu, M., additional, Ozari, M., additional, Yucetas, E., additional, Sumnu, A., additional, Doner, B., additional, Cebeci, E., additional, Ozkan, O., additional, Aktuglu, M. B., additional, Karaali, Z., additional, Koldas, M., additional, Ozturk, S., additional, Marco, H., additional, Picazo, M., additional, Da Silva, I., additional, Gonzalez, A., additional, Arce, Y., additional, Gracia, S., additional, Corica, M., additional, Llobet, J., additional, Diaz, M., additional, Ballarin, J., additional, Schonermarck, U., additional, Hagele, H., additional, Baumgartner, A., additional, Fischereder, M., additional, Muller, S., additional, Oliveira, C. B. L., additional, Oliveira, A. S. A., additional, Carvalho, C. J. B., additional, Pessoa, C. T. B. C., additional, Sette, L. H. B. C., additional, Fernandes, G. V., additional, Cavalcante, M. A. G. M., additional, Valente, L. M., additional, Wan, Q., additional, Hu, H., additional, He, Y., additional, Li, T., additional, Aazair, N., additional, Houmaid, Z., additional, Rhair, A., additional, Bennani, N., additional, Demin, A., additional, Petrova, O., additional, Kotova, O., additional, Demina, L., additional, Roccatello, D., additional, Sciascia, S., additional, Rossi, D., additional, Naretto, C., additional, Baldovino, S., additional, Alpa, M., additional, Salussola, I., additional, Modena, V., additional, Zakharova, E. V., additional, Vinogradova, O. V., additional, Stolyarevich, E. S., additional, Yap, D. Y. H., additional, Chan, T. M., additional, Thanaraj, V., additional, Ponnusamy, A., additional, Pillai, S., additional, Argentiero, L., additional, Schena, A., additional, Rossini, M., additional, Manno, C., additional, Castellano, G., additional, Martino, M., additional, Mitrotti, A., additional, Giliberti, M., additional, Digiorgio, C., additional, Di Palma, A. M., additional, Battaglia, M., additional, Ditonno, P., additional, Grandaliano, G., additional, Gesualdo, L., additional, Neprintseva, N., additional, Tchebotareva, N., additional, Bobkova, I., additional, Kozlovskaya, L., additional, Rabrenovi , V., additional, Kova Evi , Z., additional, Jovanovi , D., additional, Rabrenovi , M., additional, Anti , S., additional, Ignjatovi , L., additional, Petrovi , M., additional, Longhi, S., additional, Del Vecchio, L., additional, Vigano, S., additional, Casartelli, D., additional, Bigi, M. C., additional, Corti, M., additional, Limardo, M., additional, Tentori, F., additional, Pontoriero, G., additional, Zeraati, A. A., additional, Shariati Sarabi, Z., additional, Davoudabadi Farahani, A., additional, Mirfeizi, Z., additional, and Bae, E., additional

Published
2014
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23. CYSTIC DISEASE AND CILIOPATHIES

Author

Hoshino, J., primary, Suwabe, T., additional, Sumida, K., additional, Mise, K., additional, Hayami, N., additional, Kawada, M., additional, Imafuku, A., additional, Hiramatsu, R., additional, Hasegawa, E., additional, Sawa, N., additional, Ubara, Y., additional, Takaichi, K., additional, Yamamoto, J., additional, Ishikawa, Y., additional, Nakagaki, T., additional, Shibazaki, S., additional, Nishio, S., additional, Atsumi, T., additional, Westland, R., additional, Verbitsky, M., additional, Vukojevic, K., additional, Perry, B. J., additional, Fasel, D. A., additional, Zwijnenburg, P. J. G., additional, Gille, J. J. P., additional, Bokenkamp, A., additional, D'Agati, V. D., additional, Gharavi, A. G., additional, Schreuder, M. F., additional, Van Wijk, J. A. E., additional, Sanna-Cherchi, S., additional, Rodriguez, D., additional, Riwanto, M., additional, Edenhofer, I., additional, Segerer, S., additional, Wuthrich, R. P., additional, Kapoor, S., additional, Raaijmakers, A. M. J., additional, Mekahli, D., additional, Van Dyck, M., additional, Corveleyn, A., additional, Allegaert, K., additional, Deviendt, K., additional, Kuypers, D., additional, Claes, K., additional, and Levtchenko, E. N., additional

Published
2014
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26. A case of familial lecithin-cholesterol acyltransferase deficiency on hemodialysis for over 20 years

Author

Tsuchiya, Y., primary, Ubara, Y., additional, Hiramatsu, R., additional, Suwabe, T., additional, Hoshino, J., additional, Sumida, K., additional, Hasegawa, E., additional, Yamanouchi, M., additional, Hayami, N., additional, Marui, Y., additional, Sawa, N., additional, Hara, S., additional, Takaichi, K., additional, and Oohashi, K., additional

Published
2011
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27. Complete remission of myeloperoxidase-anti-neutrophil cytoplasmic antibody-associated crescentic glomerulonephritis complicated with rheumatoid arthritis using a humanized anti-interleukin 6 receptor antibody

Author

Sumida, K., primary, Ubara, Y., additional, Suwabe, T., additional, Hayami, N., additional, Hiramatsu, R., additional, Hasegawa, E., additional, Yamanouchi, M., additional, Hoshino, J., additional, Sawa, N., additional, Takemoto, F., additional, Takaichi, K., additional, and Ohashi, K., additional

Published
2011
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28. Pathophysiology and clinical studies in CKD 5D

Author

Konda, R., primary, Osawa, T., additional, Nozawa, T., additional, Sugimura, J., additional, Fujioka, T., additional, Ishimoto, Y., additional, Ohki, T., additional, Uchida, L., additional, Kotera, N., additional, Tanaka, M., additional, Tanaka, S., additional, Sugimoto, T., additional, Mise, N., additional, Wu, H.-Y., additional, Ko, M.-J., additional, Yang, J.-Y., additional, Hu, F.-C., additional, Chen, S.-I., additional, Jee, S.-H., additional, Chiu, H.-C., additional, Zumrutdal, A., additional, Hur, E., additional, Toz, H., additional, Ozkahya, M., additional, Usta, M., additional, Kayikcioglu, L. M., additional, Sezis, M., additional, Asci, G., additional, Kahvecioglu, S., additional, Duman, S., additional, Ok, E., additional, Sakaguchi, Y., additional, Sonoda, M., additional, Kawabata, H., additional, Niihata, K., additional, Suzuki, A., additional, Shoji, T., additional, Tsubakihara, Y., additional, Emami Naini, A., additional, Moradi, M., additional, Mortazavi, M., additional, Shirani, F., additional, Gholamrezaei, A., additional, Demir, S., additional, San, M., additional, Koken, T., additional, Seok, S.-J., additional, Gil, H.-w., additional, Yang, J.-O., additional, Lee, E.-Y., additional, Hong, S.-y., additional, Stavroulopoulos, A., additional, Kossivakis, A., additional, Aresti, V., additional, Stamogiannos, G., additional, Kalliaropoulos, A., additional, Mentis, A., additional, Azak, A., additional, Huddam, B., additional, Kocak, G., additional, Altas, A. B., additional, Sakaci, M., additional, Yalcin, F., additional, Ortabozkoyun, L., additional, Duranay, M., additional, Korukluoglu, G., additional, Eitner, F., additional, Scheithauer, S., additional, Mankartz, J., additional, Haefner, H., additional, Nowicki, K., additional, Floege, J., additional, Lemmen, S., additional, Hara, S., additional, Tanaka, K., additional, Suwabe, T., additional, Ubara, Y., additional, Takaichi, K., additional, Deleuze, S., additional, Bargnoux, A. S., additional, Rivory, J. P., additional, Rouanet, C., additional, Maurice, F., additional, Selcer, I., additional, Cristol, J. P., additional, Dou, Y., additional, Thijssen, S., additional, Ouellet, G., additional, Kruse, A., additional, Rosales, L., additional, Kotanto, P., additional, Levin, N. W., additional, Shahidi, S., additional, Sajjadieh, S., additional, Scholmann, T., additional, Straub, M., additional, Wagner, D., additional, Fliser, D., additional, Sester, M., additional, Sester, U., additional, Sikole, A., additional, Trajceska, L., additional, Selim, G., additional, Gelev, S., additional, Dzekova, P., additional, Amitov, V., additional, Arsov, S., additional, Strempska, B., additional, Bilinska, M., additional, Weyde, W., additional, Koszewicz, M., additional, Madziarska, K., additional, Golebiowski, T., additional, Klinger, M., additional, Ochi, A., additional, Ishimura, E., additional, Tsujimoto, Y., additional, Kakiya, R., additional, Tabata, T., additional, Mori, K., additional, Yasuda, H., additional, Nishizawa, Y., additional, Inaba, M., additional, Ezeonyeji, A., additional, Borg, F., additional, Harnett, P., additional, Dasgupta, B., additional, Raikou, V. D., additional, Kyriaki, D., additional, Zeggos, N., additional, Skalioti, C., additional, Tzanatou, H., additional, Boletis, J. N., additional, Viaene, L., additional, Meijers, B., additional, Bammens, B., additional, Vanrenterghem, Y., additional, Vanderschueren, D., additional, Evenepoel, P., additional, Ryu, D.-R., additional, An, H. R., additional, Ryu, J.-H., additional, Yu, M., additional, Kim, S.-J., additional, Kang, D.-H., additional, Choi, K. B., additional, Miyamoto, T., additional, Rashid Qureshi, A., additional, Anderstam, B., additional, Yamamoto, T., additional, Alvestrand, A., additional, Stenvinkel, P., additional, Lindholm, B., additional, Axelsson, J., additional, Zitt, E., additional, Manamley, N., additional, Vervloet, M., additional, Georgianos, P., additional, Sarafidis, P., additional, Kanaki, A., additional, Divani, M., additional, Haidich, A. B., additional, Sioulis, A., additional, Liakopoulos, V., additional, Papagianni, A., additional, Nikolaidis, P., additional, Lasaridis, A., additional, Morgado, E., additional, Pinho, A., additional, Guedes, A., additional, Guerreiro, R., additional, Mendes, P., additional, Bexiga, I., additional, Silva, A., additional, Marques, J., additional, and Neves, P., additional

Published
2011
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31. Rectus sheath haematoma in a patient receiving haemodialysis

Author

Takemoto, F., primary, Okuda, I., additional, Sawa, N., additional, Hoshino, J., additional, Hasegawa, E., additional, Sumida, K., additional, Yamanouchi, M., additional, Hayami, N., additional, Suwabe, T., additional, Nakamura, M., additional, Ubara, Y., additional, and Takaichi, K., additional

Published
2010
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34. A patient with pregnancy-related acute abdomen after hemodialysis for over 18 years

Author

Saito, T., primary, Ubara, Y., additional, Suwabe, T., additional, Higa, Y., additional, Nakanishi, S., additional, Hoshino, J., additional, Sawa, N., additional, Katori, H., additional, Takemoto, F., additional, Marui, R., additional, Nakamura, M., additional, Tomikawa, S., additional, Hara, S., additional, Tohbai, H., additional, and Takaichi, K., additional

Published
2009
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37. Nonlinear-laser effects in NH4H2PO4(ADP) and ND4D2PO4(DADP) single crystals: almost two-octave multi-wavelength Stokes and anti-Stokes combs, cascaded lasing in UV and visible ranges with the involving of the second and third harmonic generation

Author

Kaminskii, A A, primary, Dolbinina, V V, additional, Rhee, H, additional, Eichler, H J, additional, Ueda, K, additional, Takaichi, K, additional, Shirakawa, A, additional, Tokurakawa, M, additional, Dong, J, additional, and Jaque, D, additional

Published
2008
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38. Nonlinear-laserχ(3)- andχ(2)-effects in fine-grained highly transparent optical Ba(Mg,Zr,Ta)O3ceramics and their microhardness

Author

Kaminskii, A. A., primary, Akchurin, M. Sh., additional, Tanaka, N., additional, Eichler, H. J., additional, Rhee, H., additional, Ueda, K., additional, Takaichi, K., additional, Shirakawa, A., additional, Tokurakawa, M., additional, Dong, J., additional, Kintaka, Y., additional, Kuretake, S., additional, and Sakabe, Y., additional

Published
2008
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44. New nonlinear-laser effects in crystalline fine-grained ceramics based on cubic Sc2O3 and Lu2O3 oxides: second and third harmonic generation, and cascaded self-sum-frequency mixing in UV spectral region

Author

Kaminskii, A A, primary, Rhee, H, additional, Eichler, H J, additional, Ueda, K, additional, Takaichi, K, additional, Shirakawa, A, additional, Tokurakawa, M, additional, Dong, J, additional, Yagi, H, additional, and Yanagitani, T, additional

Published
2007
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46. A pediatric occurrence of crescentic glomerulonephritis associated with antineutrophil cytoplasmic antibodies and mesangial IgA deposits

Author

Jimbo, R., primary, Ubara, Y., additional, Tagami, T., additional, Higa, Y., additional, Suwabe, T., additional, Nakanishi, S., additional, Sogawa, Y., additional, Nomura, K., additional, Kadoguchi, H., additional, Hoshino, J., additional, Sawa, N., additional, Katori, H., additional, Takemoto, F., additional, Hara, S., additional, Ohashi, K., additional, and Takaichi, K., additional

Published
2007
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49. Cyst infection in autosomal dominant polycystic kidney disease: causative microorganisms and susceptibility to lipid-soluble antibiotics.

Author

Ubara, Y., Takaichi, K., Suwabe, T., Kikuchi, K., Hazue, R., Mise, K., Hamanoue, S., Ueno, T., Sumida, K., Hayami, N., Hoshino, J., Araoka, H., Imafuku, A., Kawada, M., Hiramatsu, R., Hasegawa, E., and Sawa, N.

Subjects
*POLYCYSTIC kidney disease, *CYSTS (Pathology), *CYSTIC kidney disease, *ANTIBIOTICS, *EFFECT of antibiotics on microorganisms, *LIPIDS, *FLUOROQUINOLONES
Abstract

Cyst infection is a frequent and serious complication of autosomal dominant polycystic kidney disease (ADPKD). Lipid-soluble antibiotics like fluoroquinolones show good penetration into cysts and are recommended for cyst infection, but causative microorganisms are often resistant to these agents. This study investigated the profile of the microorganisms causing cyst infection in ADPKD, their susceptibility to lipid-soluble antibiotics, and clinical outcomes. This retrospective study reviewed all ADPKD patients admitted to Toranomon Hospital with a diagnosis of cyst infection from January 2004 to March 2014. All patients who underwent cyst drainage and had positive cyst fluid cultures were enrolled. Patients with positive blood cultures who satisfied our criteria for cyst infection or probable infection were also enrolled. There were 99 episodes with positive cyst fluid cultures and 93 episodes with positive blood cultures. The majority of patients were on dialysis. The death rate was high when infection was caused by multiple microorganisms or when there were multiple infected cysts. Gram-negative bacteria accounted for 74-79 % of the isolates in all groups, except for patients with positive hepatic cyst fluid cultures. The susceptibility of Escherichia coli to fluoroquinolones was very low in patients with hepatic cyst infection, especially those with frequent episodes and those with hepatomegaly. Fungi were detected in two episodes. Fluoroquinolone-resistant microorganisms showed a high prevalence in cyst infection. It is important to identify causative microorganisms to avoid the overuse of fluoroquinolones and to improve the outcome of cyst infection in ADPKD. [ABSTRACT FROM AUTHOR]

Published
2015
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