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9. Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi

Author

Longley, Rhea J., Grigg, Matthew J., Schoffer, Kael, Obadia, Thomas, Hyslop, Stephanie, Piera, Kim A., Nekkab, Narimane, Mazhari, Ramin, Takashima, Eizo, Tsuboi, Takafumi, Harbers, Matthias, Tetteh, Kevin, Drakeley, Chris, Chitnis, Chetan E., Healer, Julie, Tham, Wai-Hong, Sattabongkot, Jetsumon, White, Michael T., Cooper, Daniel J., Rajahram, Giri S., Barber, Bridget E., William, Timothy, Anstey, Nicholas M., and Mueller, Ivo

Published
2022
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15. Naturally acquired transmission-blocking immunity against different strains of Plasmodium vivax in a malaria endemic area in Thailand

Author

Thongpoon, Sataporn, primary, Roobsoong, Wanlapa, additional, Nguitragool, Wang, additional, Chotirat, Sadudee, additional, Tsuboi, Takafumi, additional, Takashima, Eizo, additional, Cui, Liwang, additional, Ishino, Tomoko, additional, Tachibana, Mayumi, additional, Miura, Kazutoyo, additional, and Sattabongkot, Jetsumon, additional

Published
2023
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16. Development and validation of serological markers for detecting recent Plasmodium vivax infection

Author

Longley, Rhea J., White, Michael T., Takashima, Eizo, Brewster, Jessica, Morita, Masayuki, Harbers, Matthias, Obadia, Thomas, Robinson, Leanne J., Matsuura, Fumie, Liu, Zoe S.J., Li-Wai-Suen, Connie, Tham, Wai-Hong, Healer, Julie, Huon, Christine, Chitnis, Chetan E., Nguitragool, Wang, Monteiro, Wuelton, Proietti, Carla, Doolan, Denise L., Siqueira, Andre M., Ding, Xavier C., Gonzalez, Iveth J., Kazura, James, Lacerda, Marcus, Sattabongkot, Jetsumon, Tsuboi, Takafumi, and Mueller, Ivo

Subjects
Plasmodium vivax -- Testing -- Methods, Serodiagnosis -- Methods, Malaria -- Diagnosis -- Control, Biological markers -- Testing -- Methods, Biological sciences, Health
Abstract

A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study developed a panel of serological exposure markers capable of classifying individuals with recent P. vivax infections who have a high likelihood of harboring hypnozoites. We measured IgG antibody responses to 342 P. vivax proteins in longitudinal clinical cohorts conducted in Thailand and Brazil and identified candidate serological markers of exposure. Candidate markers were validated using samples from year-long observational cohorts conducted in Thailand, Brazil and the Solomon Islands and antibody responses to eight P. vivax proteins classified P. vivax infections in the previous 9 months with 80% sensitivity and specificity. Mathematical models demonstrate that a serological testing and treatment strategy could reduce P. vivax prevalence by 59-69%. These eight antibody responses can serve as a biomarker, identifying individuals who should be targeted with anti-hypnozoite therapy. Plasmodium vivax can cause a clinically silent liver-stage infection that can reactivate, triggering blood-stage disease. A new test measuring antibody responses can identify P. vivax carriers for targeted treatment intervention., Author(s): Rhea J. Longley [sup.1] [sup.2] [sup.3] , Michael T. White [sup.4] , Eizo Takashima [sup.5] , Jessica Brewster [sup.1] , Masayuki Morita [sup.5] , Matthias Harbers [sup.6] [sup.7] , [...]

Published
2020
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17. Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria

Author

Hagadorn, Kelly A., Peterson, Mary E., Kole, Hemanta, Scott, Bethany, Skinner, Jeff, Diouf, Ababacar, Takashima, Eizo, Ongoiba, Aissata, Doumbo, Safiatou, Doumtabe, Didier, Li, Shanping, Sekar, Padmapriya, Yan, Mei, Zhu, Chengsong, Nagaoka, Hikaru, Kanoi, Bernard N., Li, Quan-Zhen, Long, Carole, Long, Eric O., Kayentao, Kassoum, Jenks, Scott A., Sanz, Ignacio, Tsuboi, Takafumi, Traore, Boubacar, Bolland, Silvia, Miura, Kazutoyo, Crompton, Peter D., and Hopp, Christine S.

Published
2024
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18. Naturally Acquired Transmission-Blocking Immunity Against Different Strains of Plasmodium vivax in a Malaria-Endemic Area in Thailand.

Author

Thongpoon, Sataporn, Roobsoong, Wanlapa, Nguitragool, Wang, Chotirat, Sadudee, Tsuboi, Takafumi, Takashima, Eizo, Cui, Liwang, Ishino, Tomoko, Tachibana, Mayumi, Miura, Kazutoyo, and Sattabongkot, Jetsumon

Subjects
PLASMODIUM vivax, IMMUNITY, NATURAL immunity, ARBOVIRUSES, PLASMODIUM, VACCINE development, TRYPANOSOMA
Abstract

Background Human immunity triggered by natural malaria infections impedes parasite transmission from humans to mosquitoes, leading to interest in transmission-blocking vaccines. However, immunity characteristics, especially strain specificity, remain largely unexplored. We investigated naturally acquired transmission-blocking immunity (TBI) against Plasmodium vivax , a major malaria parasite. Methods Using the direct membrane-feeding assay, we assessed TBI in plasma samples and examined the role of antibodies by removing immunoglobulins through protein G/L adsorption before mosquito feeding. Strain specificity was evaluated by conducting a direct membrane-feeding assay with plasma exchange. Results Blood samples from 47 patients with P vivax were evaluated, with 37 plasma samples successfully infecting mosquitoes. Among these, 26 showed inhibition before immunoglobulin depletion. Despite substantial immunoglobulin removal, 4 samples still exhibited notable inhibition, while 22 had reduced blocking activity. Testing against heterologous strains revealed some plasma samples with broad TBI and others with strain-specific TBI. Conclusions Our findings indicate that naturally acquired TBI is mainly mediated by antibodies, with possible contributions from other serum factors. The transmission-blocking activity of plasma samples varied by the tested parasite strain, suggesting single polymorphic or multiple targets for naturally acquired TBI. These observations improve understanding of immunity against P vivax and hold implications for transmission-blocking vaccine development. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Host immunity to Plasmodium falciparum and the assessment of emerging artemisinin resistance in a multinational cohort

Author

Ataide, Ricardo, Ashley, Elizabeth A., Powell, Rosanna, Chan, Jo-Anne, Malloy, Michael J., O’Flaherty, Katherine, Takashima, Eizo, Langer, Christine, Tsuboi, Takafumi, Dondorp, Arjen M., Day, Nicholas P., Dhorda, Mehul, Fairhurst, Rick M., Lim, Pharath, Amaratunga, Chanaki, Pukrittayakamee, Sasithon, Hien, Tran Tinh, Htut, Ye, Mayxay, Mayfong, Faiz, M. Abul, Beeson, James G., Nosten, Francois, Simpson, Julie A., White, Nicholas J., and Fowkes, Freya J. I.

Published
2017

29. Naturally acquired antibodies to gametocyte antigens are associated with reduced transmission of Plasmodium vivax gametocytes to Anopheles arabiensis mosquitoes

Author

Tebeje, Surafel K., primary, Chali, Wakweya, additional, Hailemeskel, Elifaged, additional, Ramjith, Jordache, additional, Gashaw, Abrham, additional, Ashine, Temesgen, additional, Nebret, Desalegn, additional, Esayas, Endashaw, additional, Emiru, Tadele, additional, Tsegaye, Tizita, additional, Teelen, Karina, additional, Lanke, Kjerstin, additional, Takashima, Eizo, additional, Tsuboi, Takafumi, additional, Salinas, Nichole D., additional, Tolia, Niraj H., additional, Narum, David, additional, Drakeley, Chris, additional, Witkowski, Benoit, additional, Vantaux, Amelie, additional, Jore, Matthijs M., additional, Stone, William J. R., additional, Hansen, Ivo S., additional, Tadesse, Fitsum G., additional, and Bousema, Teun, additional

Published
2023
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30. Autoantibodies Inhibit Plasmodium falciparum Growth and Associate with Protection from Clinical Malaria

Author

Hagadorn, Kelly A., primary, Peterson, Mary E., additional, Kole, Hemanta, additional, Scott, Bethany, additional, Skinner, Jeff, additional, Takashima, Eizo, additional, Diouf, Ababacar, additional, Ongoiba, Aissata, additional, Doumbo, Safiatou, additional, Doumtabe, Didier, additional, Li, Shanping, additional, Sekar, Padmapriya, additional, Yan, Mei, additional, Zhu, Chengsong, additional, Nagaoka, Hikaru, additional, Kanoi, Bernard N., additional, Li, Quan-Zhen, additional, Long, Carole, additional, Long, Eric O., additional, Kayentao, Kassoum, additional, Jenks, Scott A., additional, Sanz, Ignacio, additional, Tsuboi, Takafumi, additional, Traore, Boubacar, additional, Bolland, Silvia, additional, Miura, Kazutoyo, additional, Crompton, Peter D., additional, and Hopp, Christine S., additional

Published
2023
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34. A novel asexual blood-stage malaria vaccine candidate: PfRipr5 formulated with human-use adjuvants induces potent growth inhibitory antibodies

Author

Takashima, Eizo, primary, Nagaoka, Hikaru, additional, Correia, Ricardo, additional, Alves, Paula M., additional, Roldão, António, additional, Christensen, Dennis, additional, Guderian, Jeffrey A., additional, Fukushima, Akihisa, additional, Viebig, Nicola K., additional, Depraetere, Hilde, additional, and Tsuboi, Takafumi, additional

Published
2022
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37. Assessment of IgG3 as a serological exposure marker for Plasmodium vivax in areas with moderate–high malaria transmission intensity

Author

Tayipto, Yanie, primary, Rosado, Jason, additional, Gamboa, Dionicia, additional, White, Michael T., additional, Kiniboro, Benson, additional, Healer, Julie, additional, Opi, D. Herbert, additional, Beeson, James G., additional, Takashima, Eizo, additional, Tsuboi, Takafumi, additional, Harbers, Matthias, additional, Robinson, Leanne, additional, Mueller, Ivo, additional, and Longley, Rhea J., additional

Published
2022
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39. Comparison of Antibody Responses and Parasite Clearance in Artemisinin Therapeutic Efficacy Studies in the Democratic Republic of Congo and Asia

Author

Cutts, Julia C, primary, O’Flaherty, Katherine, additional, Zaloumis, Sophie G, additional, Ashley, Elizabeth A, additional, Chan, Jo Anne, additional, Onyamboko, Marie A, additional, Fanello, Caterina, additional, Dondorp, Arjen M, additional, Day, Nicholas P, additional, Phyo, Aung Pyae, additional, Dhorda, Mehul, additional, Imwong, Mallika, additional, Fairhurst, Rick M, additional, Lim, Pharath, additional, Amaratunga, Chanaki, additional, Pukrittayakamee, Sasithon, additional, Hien, Tran Tinh, additional, Htut, Ye, additional, Mayxay, Mayfong, additional, Faiz, M Abdul, additional, Takashima, Eizo, additional, Tsuboi, Takafumi, additional, Beeson, James G, additional, Nosten, Francois, additional, Simpson, Julie A, additional, White, Nicholas J, additional, and Fowkes, Freya J I, additional

Published
2022
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41. Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors

Author

Saito, Fumiji, Hirayasu, Kouyuki, Satoh, Takeshi, Wang, Christian W., Lusingu, John, Arimori, Takao, Shida, Kyoko, Palacpac, Nirianne Marie Q., Itagaki, Sawako, Iwanaga, Shiroh, Takashima, Eizo, Tsuboi, Takafumi, Kohyama, Masako, Suenaga, Tadahiro, Colonna, Marco, Takagi, Junichi, Lavstsen, Thomas, Horii, Toshihiro, and Arase, Hisashi

Published
2017
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42. The Lipid-Binding Defective Dynamin 2 Mutant in Charcot-Marie-Tooth Disease Impairs Proper Actin Bundling and Actin Organization in Glomerular Podocytes

Author

Hamasaki, Eriko, primary, Wakita, Natsuki, additional, Yasuoka, Hiroki, additional, Nagaoka, Hikaru, additional, Morita, Masayuki, additional, Takashima, Eizo, additional, Uchihashi, Takayuki, additional, Takeda, Tetsuya, additional, Abe, Tadashi, additional, Lee, Ji-Won, additional, Iimura, Tadahiro, additional, Saleem, Moin A, additional, Ogo, Naohisa, additional, Asai, Akira, additional, Narita, Akihiro, additional, Takei, Kohji, additional, and Yamada, Hiroshi, additional

Published
2022
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43. Anti-Gametocyte Antigen Humoral Immunity and Gametocytemia During Treatment of Uncomplicated Falciparum Malaria: A Multi-National Study

Author

O’Flaherty, Katherine, primary, Chan, Jo-Anne, additional, Cutts, Julia C., additional, Zaloumis, Sophie G., additional, Ashley, Elizabeth A., additional, Phyo, Aung Pyae, additional, Drew, Damien R., additional, Dondorp, Arjen M., additional, Day, Nicholas P., additional, Dhorda, Mehul, additional, Fairhurst, Rick M., additional, Lim, Pharath, additional, Amaratunga, Chanaki, additional, Pukrittayakamee, Sasithon, additional, Hien, Tran Tinh, additional, Htut, Ye, additional, Mayxay, Mayfong, additional, Faiz, M. Abul, additional, Mokuolu, Olugbenga A., additional, Onyamboko, Marie A., additional, Fanello, Caterina, additional, Takashima, Eizo, additional, Tsuboi, Takafumi, additional, Theisen, Michael, additional, Nosten, Francois, additional, Beeson, James G., additional, Simpson, Julie A., additional, White, Nicholas J., additional, and Fowkes, Freya J. I., additional

Published
2022
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45. Additional file 1 of Naturally acquired antibody kinetics against Plasmodium vivax antigens in people from a low malaria transmission region in western Thailand

Author

Liu, Zoe Shih-Jung, Sattabongkot, Jetsumon, White, Michael, Chotirat, Sadudee, Kumpitak, Chalermpon, Takashima, Eizo, Harbers, Matthias, Tham, Wai-Hong, Healer, Julie, Chitnis, Chetan E., Tsuboi, Takafumi, Mueller, Ivo, and Longley, Rhea J.

Subjects
parasitic diseases
Abstract

Additional File 1: Fig S1. Schematic representation of the relationship between the population-level and individual-level parameters for the half-life of the short-lived ASCs. Fig S2. Total IgG kinetic profiles against 52 P. vivax antigens in 34 Thai patients with symptomatic P. vivax infections. Fig S3. Adjusted total IgG kinetic profiles at an individual level following symptomatic infections. Fig S4. Comparison of the adjusted peak IgG subclass magnitude between symptomatic Thai patients and the PNG hyperimmune pool. Fig S5. Comparison of the peak IgM magnitude between symptomatic Thai patients and malaria-free individuals. Fig S6. Unadjusted IgM kinetics against 15 P. vivax antigens in 34 Thai individuals following symptomatic P. vivax infections. Fig S7. Distribution of data for estimated half-lives of antibodies and ASCs against IgG-immunogenic antigens following symptomatic P. vivax infections in the Thai symptomatic cohort. Fig S8. Comparison of adjusted total IgG against 27 P. vivax antigens following symptomatic or asymptomatic P. vivax infections.

Published
2022
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46. Additional file 2 of Naturally acquired antibody kinetics against Plasmodium vivax antigens in people from a low malaria transmission region in western Thailand

Author

Liu, Zoe Shih-Jung, Sattabongkot, Jetsumon, White, Michael, Chotirat, Sadudee, Kumpitak, Chalermpon, Takashima, Eizo, Harbers, Matthias, Tham, Wai-Hong, Healer, Julie, Chitnis, Chetan E., Tsuboi, Takafumi, Mueller, Ivo, and Longley, Rhea J.

Subjects
parasitic diseases, complex mixtures
Abstract

Additional file 2: Table S1. Immunogenicity of total IgG against 52 P. vivax antigens at 1-week post-infection in Thai symptomatic volunteers. Table S2. P. vivax proteins used in this study. Table S3. Immunogenicity of total IgG against 27 IgG-immunogenic P. vivax antigens at 0-week since infection in Thai asymptomatic volunteers.

Published
2022
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47. Additional file 1 of Comparison of total immunoglobulin G antibody responses to different protein fragments of Plasmodium vivax Reticulocyte binding protein 2b

Author

Bourke, Caitlin, Takashima, Eizo, Chan, Li-Jin, Dietrich, Melanie H., Mazhari, Ramin, White, Michael, Sattabongkot, Jetsumon, Tham, Wai-Hong, Tsuboi, Takafumi, Mueller, Ivo, and Longley, Rhea

Subjects
equipment and supplies, human activities
Abstract

Additional file 1: Figure S1. SDS-PAGE (10%) visualisation of purified recombinant proteins used for magnetic bead coupling. Figure S2. Standard curve serial dilutions for plates used in this study of protein-magnetic bead couplings with the hyper-immune positive control pool of individuals from Papua New Guinea.

Published
2022
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48. Characterization of Naturally Acquired Immunity to a Panel of Antigens Expressed in Mature P. falciparum Gametocytes

Author

Muthui, Michelle K, Takashima, Eizo, Omondi, Brian R, Kinya, Christine, Muasya, William I, Nagaoka, Hikaru, Mwai, Kennedy W, Orindi, Benedict, Wambua, Juliana, Bousema, Teun, Drakeley, Chris, Blagborough, Andrew M, Marsh, Kevin, Bejon, Philip, Kapulu, Melissa C, and Apollo - University of Cambridge Repository

Subjects
Plasmodium falciparum, Protozoan Proteins, Antibodies, Protozoan, mature gametocytes, Antigens, Protozoan, Seroepidemiologic Studies, parasitic diseases, Antibody Formation, Animals, Humans, naturally acquired immunity, seroepidemiology, Malaria, Falciparum, malaria transmission
Abstract

INTRODUCTION: Naturally acquired immune responses against antigens expressed on the surface of mature gametocytes develop in individuals living in malaria-endemic areas. Evidence suggests that such anti-gametocyte immunity can block the development of the parasite in the mosquito, thus playing a role in interrupting transmission. A better comprehension of naturally acquired immunity to these gametocyte antigens can aid the development of transmission-blocking vaccines and improve our understanding of the human infectious reservoir. METHODS: Antigens expressed on the surface of mature gametocytes that had not previously been widely studied for evidence of naturally acquired immunity were identified for protein expression alongside Pfs230-C using either the mammalian HEK293E or the wheat germ cell-free expression systems. Where there was sequence variation in the candidate antigens (3D7 vs a clinical isolate PfKE04), both variants were expressed. ELISA was used to assess antibody responses against these antigens, as well as against crude stage V gametocyte extract (GE) and AMA1 using archived plasma samples from individuals recruited to participate in malaria cohort studies. We analyzed antibody levels (estimated from optical density units using a standardized ELISA) and seroprevalence (defined as antibody levels greater than three standard deviations above the mean levels of a pool of malaria naïve sera). We described the dynamics of antibody responses to these antigens by identifying factors predictive of antibody levels using linear regression models. RESULTS: Of the 25 antigens selected, seven antigens were produced successfully as recombinant proteins, with one variant antigen, giving a total of eight proteins for evaluation. Antibodies to the candidate antigens were detectable in the study population (N = 216), with seroprevalence ranging from 37.0% (95% CI: 30.6%, 43.9%) for PSOP1 to 77.8% (95% CI: 71.6%, 83.1%) for G377 (3D7 variant). Responses to AMA1 and GE were more prevalent than those to the gametocyte proteins at 87.9% (95% CI: 82.8%, 91.9%) and 88.3% (95% CI: 83.1%, 92.4%), respectively. Additionally, both antibody levels and breadth of antibody responses were associated with age and concurrent parasitaemia. CONCLUSION: Age and concurrent parasitaemia remain important determinants of naturally acquired immunity to gametocyte antigens. Furthermore, we identify novel candidates for transmission-blocking activity evaluation.

Published
2021
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49. Identifying Targets of Protective Antibodies against Severe Malaria in Papua, Indonesia, Using Locally Expressed Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1

Author

Rambhatla, Janavi S., primary, Tonkin-Hill, Gerry Q., additional, Takashima, Eizo, additional, Tsuboi, Takafumi, additional, Noviyanti, Rintis, additional, Trianty, Leily, additional, Sebayang, Boni F., additional, Lampah, Daniel A., additional, Marfurt, Jutta, additional, Price, Ric N., additional, Anstey, Nicholas M., additional, Papenfuss, Anthony T., additional, Damelang, Timon, additional, Chung, Amy W., additional, Duffy, Michael F., additional, and Rogerson, Stephen J., additional

Published
2022
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