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244 results on '"Takasugi H"'

6. Solid-phase crystal growth of molecular-beam-deposited amorphous GaAs.

Author

Yokoyama, S., Yui, D., Tanigawa, H., Takasugi, H., and Kawabe, M.

Subjects
CRYSTALLIZATION, MOLECULAR beams, EPITAXY
Abstract

Focuses on a study which investigated solid-phase crystallization processes of molecular-beam-deposited amorphous GaAs with various As/Ga composition ratios. Growth that takes place in a low-temperature region; Factor that strongly affect the epitaxial growth rate; Manner of examining the atomic bonding state in the amorphous GaAs.

Published
1987
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7. The origin of a highly resistive layer at a growth-interrupted interface of GaAs grown by molecular-beam epitaxy.

Author

Iimura, Y., Shiraishi, T., Takasugi, H., and Kawabe, M.

Subjects
INTERFACES (Physical sciences), MOLECULAR beam epitaxy, GALLIUM arsenide
Abstract

Presents information on a study which analyzed the origin of the formation of a highly resistive layer around a growth-interrupted interface in gallium arsenide. Problems in the fabrication of electronic devices by molecular beam epitaxy; Measurement of the capacitance-voltage carrier profile; Clarification of the existence of deep-trap levels at the growth-interrupted interface.

Published
1987
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26. ChemInform Abstract: Inhibitors of Acyl‐CoA:Cholesterol O‐Acyltransferase. Part 3. Discovery of a Novel Series of N‐Alkyl‐N‐[(fluorophenoxy)benzyl]‐N′‐arylureas with Weak Toxicological Effects on Adrenal Glands.

Author

TANAKA, A., primary, TERASAWA, T., additional, HAGIHARA, H., additional, ISHIBE, N., additional, SAWADA, M., additional, SAKUMA, Y., additional, HASHIMOTO, M., additional, TAKASUGI, H., additional, and TANAKA, H., additional

Published
1999
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49. Discovery of Diphenyloxazole and Nδ-Z-Ornithine Derivatives as Highly Potent and Selective Human Prostaglandin EP<INF>4</INF> Receptor Antagonists

Author

Hattori, K., Tanaka, A., Fujii, N., Takasugi, H., Tenda, Y., Tomita, M., Nakazato, S., Nakano, K., Kato, Y., Kono, Y., Murai, H., and Sakane, K.

Abstract

Two novel classes of diphenyloxazole and Nδ-Z-ornithine derivatives as highly potent and selective EP4 antagonists have been discovered. The optimized diphenyloxzole 8 and Nδ-Z-ornithine 11 effectively competed with [3H]PGE2 binding to human recombinant EP4, with Ki values of 0.30 nM and 0.91 nM, respectively, and were selective for all members of the human prostanoid receptor family. 8 was shown to exhibit good pharmacokinetic properties in rats and dogs and potent inhibitory activity toward in vitro PGE2-promoted IgE synthesis.

Published
2005

50. Anti-Helicobacter pylori Agents. 5. 2-(Substituted guanidino)-4-arylthiazoles and Aryloxazole Analogues

Author

Katsura, Y., Nishino, S., Inoue, Y., Sakane, K., Matsumoto, Y., Morinaga, C., Ishikawa, H., and Takasugi, H.

Abstract

To extend the SAR study of guanidinothiazoles as a structurally novel class of anti-H. pylori agents, a series of 2-(substituted guanidino)-4-arylthiazoles and some 4-aryloxazole analogues were synthesized and evaluated for antimicrobial activity against H. pylori. Some of them were also subjected to H2 antagonist and gastric antisecretory assays. Several arylthiazoles were identified as potent anti-H. pylori agents, and of these, thienylthiazole derivative 44 exhibited the strongest activity (MIC = 0.0065 μg/mL) among the compounds obtained in our guanidinothiazole studies. Although 44 was void of H2 antagonist activity, pyridylthiazole derivative 39 had both potent anti-H. pylori and H2 antagonist activities. Thiazolylthiazole derivative 46 also showed potent anti-H. pylori activity, but the H2 antagonist activity was weak. On the other hand, no attractive activities were found in pyrimidyl, oxazolyl, isoxazolyl, imidazolyl, and oxadiazolylthiazole derivatives. The anti-H. pylori activity of the aryloxazole analogues was weaker than those of the corresponding arylthiazole derivatives, though they had potent H2 antagonist activity.

Published
2002

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