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7 results on '"Takayuki Kuragano"'

1. Serum Uric Acid Level Predicts Progression of IgA Nephropathy in Females but Not in Males.

Author

Yasuyuki Nagasawa, Ryohei Yamamoto, Tatsuya Shoji, Maki Shinzawa, Yukiko Hasuike, Katsuyuki Nagatoya, Atsushi Yamauchi, Terumasa Hayashi, Takayuki Kuragano, Toshiki Moriyama, Yoshitaka Isaka, and Takeshi Nakanishi

Subjects
Medicine, Science
Abstract

BACKGROUND:Immunoglobulin A nephropathy (IgAN) is one of most common forms of glomerulonephritis. At this point, the clinical impact of hyperuricemia on IgAN is not clear. The aim of the present study was to explore the clinical impact of hyperuricemia on the progression of IgAN. STUDY DESIGN:Multicenter retrospective cohort study. SETTING & PARTICIPANTS:935 IgAN patients who were diagnosed by kidney biopsy at Osaka University Hospital, Osaka General Hospital, and Osaka Rosai Hospital. were included in this study. PREDICTOR:Uric acid levels at renal biopsy. OUTCOMES:The outcome of interest was the time from the kidney biopsy to the time when a 50% increase in the baseline serum creatinine level was observed, which was defined as "progression". MEASUREMENTS:The baseline characteristics according to the kidney biopsy at the time of diagnosis were collected from the medical records, and included age, gender, body mass index, hypertension, diabetes (use of antidiabetic drugs), serum levels of creatinine, urinary protein, smoking status, RAAS blockers and steroid therapy. RESULTS:An elevated serum uric acid level was an independent risk factor for progression in female patients (per 1.0 mg/dL, multivariate-adjusted incident rate ratio 1.33 [95% confidence interval 1.07, 1.64], P = 0.008) but not in male patients (1.02 [0.81, 1.29], P = 0.855). To control a confounding effect of renal function on an association between serum uric acid level and progression in female patients, age- and serum creatinine-matched and propensity score-matched analyses were performed, and these results also supported the effect by uric acid on kidney disease progression independent of basal kidney function. LIMITATIONS:A cohort analyzed retorospectively. CONCLUSIONS:This study revealed that an elevated uric acid level was an independent risk factor for ESKD in female IgAN patients. Therefore, uric acid might be a treatable target in female IgAN patients.

Published
2016
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2. Efficacy of corticosteroid therapy for IgA nephropathy patients stratified by kidney function and proteinuria

Author

Maki Shinzawa, Ryohei Yamamoto, Takayuki Kuragano, Yoshitaka Isaka, Toshiki Moriyama, Atsushi Yamauchi, Katsuyuki Nagatoya, Yasuyuki Nagasawa, Terumasa Hayashi, Yukiko Hasuike, and Tatsuya Shoji

Subjects
Adult, Male, Nephrology, medicine.medical_specialty, Physiology, medicine.drug_class, 030232 urology & nephrology, Urology, Renal function, 030204 cardiovascular system & hematology, urologic and male genital diseases, Rate ratio, Nephropathy, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Adrenal Cortex Hormones, Physiology (medical), Internal medicine, medicine, Humans, Retrospective Studies, Kidney, Proteinuria, business.industry, Glomerulonephritis, IGA, Retrospective cohort study, Middle Aged, Prognosis, medicine.disease, medicine.anatomical_structure, Creatinine, Corticosteroid, Female, medicine.symptom, business, Glomerular Filtration Rate
Abstract

Steroid therapy is one of the important therapies for IgA nephropathy (IgAN), but the features of the IgAN patients who have the benefit from this therapy remained unclear. This retrospective observational study, using data of 874 patients with IgAN analyzed the proteinuria and kidney function of IgAN patients who had beneficial effect by steroid therapy. Two advantages of the present study were a large cohort and a long observational period. Corticosteroid therapy had ameliorated the kidney prognosis [incident rate ratio (IRR) 0.57 (95%CI 0.34–0.92), P = 0.029]. Because of interaction between kidney function and use of corticosteroid (P = 0.047), stratification analysis by kidney function revealed that prognosis of kidney function in IgAN patients whose eGFR was less than 60 ml/min/1.73m2 was ameliorated by corticosteroid therapy [IRR 0.50 (95%CI 0.26–0.97), P = 0.015); while, there was no change of kidney prognosis in IgAN patients whose eGFR was above 60 ml/min/1.73 m2. To make the target of corticosteroid therapy for IgAN patients more clear, IgAN patients, whose eGFR were less than 60 ml/min/1.73 m2, were stratified by proteinuria (1 g/day). In IgAN patients whose eGFR were under 60 ml/min/1.73 m2 and whose proteinuria were over 1.0 g/day, corticosteroid therapy seemed to ameliorate kidney function [IRR 0.39 (95%CI 0.19–0.86), P

Published
2020

3. PRIMARY AND SECONDARY GLOMERULONEPHRITIDES 1

Author

Masayuki Iyoda, Taihei Suzuki, Jung Eun Lee, Margherita Conrieri, Angel Sevillano, Katsuyuki Nagatoya, Shankar Prasad Nagaraju, Nicoletta Mezzina, Augusta Praça, A. Malesci, Bjørn Egil Vikse, Tajana Zeljkovic Vrkic, Fumihiko Sasai, Giuseppe Paolo Segoloni, Maki Shinzawa, Terumasa Hayashi, Yutaka Yamaguchi, Maria Elena Donadio, Inês Ferreira, Ioanna Labropoulou, Luca Vergano, Yoshikuni Nagayama, Manuel A Podestà, Guida Meneses, Takayuki Kuragano, Gisele V. Fernandes, Manohar Bairy, Yasuyuki Nagasawa, Ayse Serra Artan, Vedran Premuzic, Barbara Trezzi, Carla Guidi, Manuel Pestana, Makoto Watanabe, Donatella Vizza, Francisco Remédio, Rune Bjørneklett, Niranjan Ambekar, Evangelina Mérida, Narayan Prasad, Ana Cristina Matos, George Toulkeridis, In Mi Han, Enrique Morales, Mohit Kumar Rai, Federica Chiale, Kenichi Sumida, Ann Merethe Vågane, E. Mariz, Adrian Zugravu, Andreas Kronbichler, Michael A. Rudnicki, Praga Manuel, Maria Skoularopoulou, Maria Paola Puccinelli, Mustafa Güllülü, Helena Viana, Loredana Colla, Vasudeva Guddattu, Sung-Bae Park, Sung Jin Moon, Eduardo Gutiérrez, Hirokatsu Atsumi, Junichi Hoshino, Rajeevalochana Parthasarathy, Nimet Aktas, Renzo Bonofilgio, Carla Henriques, Ana Huerta, Jelena Kos, David Cucchiari, Gener Ismail, Renato Alberto Sinico, Anna Varberg Reisæter, Hideki Yamaya, Iuliana Andreiana, Atsushi Yamauchi, Bernardo Faria, Francesca Maria Bosetti, Noriko Hayami, Vincenzo Cantaluppi, Yoshitaka Isaka, Swapnil Karnik, Aydin Turkmen, Alexei Smirnov, Ljiljana Fodor, Jinhyuk Paek, Alberto Boido, Shinichi Uchida, Abdulmecit Yildiz, Takanori Shibata, Sei Sasaki, Xiao-Yan Wei, Ravindra Prabhu, Tiziana Stellato, Roser Torra, Eunah Hwang, Kazuyuki Tasaki, Luigi Biancone, Gutierrez-Solis Elena, Clarissa J. B. Carvalho, Gabriel Mircescu, Ana Teresa Nunes, Elisabet Ars, Tomokazu Okado, Hui Wang, Vanja Ivković, Tushar Anil Dighe, Katsuhito Ihara, Norifumi Hayashi, Roxana Jurubita, Aysegul Oruc, Yasar Caliskan, Mehmet Sukru Sever, Atul Sajgure, Aikaterini Papagianni, Katarzyna Koscielska-Kasprzak, Francesca Leone, Mario Laganović, Archana Buch, Daisuke Komukai, Carina Ferreira, Olga Galkina, Marian Klinger, Sandra Karanović, Manuela Bianciotto, Srinivas Kosuru, Maria Céu Santos, Maurizio Gallieni, Manuel Praga, Yuan-Qing Tian, Ken Iseri, Peter Påhlsson, Kenmei Takaichi, Vikas Agarwal, Manuel Burdese, Aritoshi Kida, Giulio Mengozzi, Giovanni Camussi, Yasutaka Yamamoto, Tomohiro Saito, Seiichi Matsuo, Enyu Imai, Yuki Shindo-Hirai, Edite Pereira, Nida Oztop, Gert Mayer, Tatemitsu Rai, Rosanna Coppo, Hiroshi Okuyama, Dong Ho Shin, Soichiro Iimori, Danilo Lofaro, Hiroki Adachi, Yasemin Ozluk, Maria Alina Gomes de Mattos Cavalcante, Michael C. Carlsson, Bulent Gul, Abhay Sadre, Shunsuke Goto, Vasilii Sipovskii, Kei Fukami, Hiroki Nishiwaki, Tatsuya Suwabe, Daniela Finocchietti, Yuki Matsui, Takshi Nakanishi, Ashwini Sharma, Teresa Papalia, Marijana Cˇorić, Marco D'Amico, Caro-Espada Paula Jara, Francesco Mollica, Licia Peruzzi, Yukihiro Wada, Roberta Camilla, Agata Mollica, E. O. Bogdanova, Raluca Bobeica, Cai-Li Wang, Eugen Mandache, Francesco Reggiani, Joaquim Calado, Li Lv, Elena Saganova, Fernanda Carvalho, Halil Yazici, Yan-Hui Zhang, Elisa Loiacono, Christos Bantis, Teresa Cavero, Salvatore Badalamenti, Hakon Leffler, Sigrid Lundberg, Tarun Jeloka, Ligia Petrescu, Luca Besso, Alline S. A. Oliveira, Stratis Kasimatis, Thomas Knoop, Davide Medica, Germana Daidola, E. Hernandez, Mana Yahiro, Rojas-Rivera Jorge Enrique, João M. Frazão, Kouki Mise, Toshiaki Suzuki, Yoshihiro Kuno, Atul Mulay, Jun Ito, Katarzyna Gniewek, George Efstratiadis, Marijana Ćorić, Jara Caro, Maria Stangou, Aysun Aksoy, Fernando Nolasco, Katarzyna Jakuszko, Paolo Gigliotti, Tae Hyun Yoo, Takeshi Hasegawa, Hideki Fujii, Ricardo Neto, Simona Stancu, Susana Sampaio, Camila Barbosa L Oliveira, Sindhura Lakshmi Koulmane Laxminarayana, Alaattin Yildiz, Shigeo Hara, Kei Matsumoto, Ludmila Taran, Nikoleta Maria Kouri, Shinichi Nishi, Andreea Avram, Zivka Dika, Nobuharu Kaneshima, Charan Bhadrappa Bale, Gian Marco Ghiggeri, Ashio Yoshimura, Lei Nan, Rachele Gallo, Keiji Fujimoto, Alessandro Amore, Mårten Segelmark, Luís H. B. C. Sette, Francesca Brunini, Bojan Jelaković, Lucila Maria Valente, Ryohei Yamamoto, Andreea Andronesi, Julia Kerschbaum, Inna Lastauka, Mohamed R. Daha, Akhilesh Jaiswal, Ni-Ya Jia, Jayraj Korpe, Shinichi Akiyama, Domenico Santoro, Marc A. Seelen, Ebru Acikgoz, Shoichi Maruyama, Anna Perri, Hitoshi Yokoyama, Magdalena Krajewska, Brijesh Yadav, Hyungjong Kim, Irina Zubina, Tatsuya Shoji, Yoshifumi Ubara, Claudio Angelini, Margareta Fištrek Prlić, Ian Proletov, Kentaro Nakai, Isin Kilicaslan, Antonella Radice, Prachi Kate, Sayuri Hamahata, Jose Antonio Moreno, and Marijana Zivko

Subjects
Transplantation, medicine.medical_specialty, Pediatrics, Primary (chemistry), Nephrology, business.industry, Alternative medicine, medicine, business, Intensive care medicine
Published
2014

4. Dialysis. Protein-energy wasting, inflammation and oxidative stress

Author

K. Stav, M. Righetti, Ilia Beberashvili, Gabriela Cobo, K. Stylianou, Gabriel Kocevar, L. De Nicola, Jaroslav Rosenberger, B. Jelakovic, Jeroen P. Kooman, Alessandra Testa, Roberto Pecoits-Filho, K. Kourtesi, L. Katalinic, Y. Daijo, O. Slusanschi, S. Tsuneyoshi, T. Fournier, S. Paoletti, F.M. van der Sande, G. Lefrancois, Yasuyuki Nagasawa, D. Ibarrola, Christina Marelli, K. Amar, Ana Vigil, A. Corbu-Stancu, O. Ortega, C. Garcia Lacalle, F. Stefani, Vincenzo Cantaluppi, Aritoshi Kida, S. Ozenne, Diana Dragomir, Dominique Sappey-Marinier, C. Barbulescu, M. Sawa, S. Vougazianos, R. Camacho, K. Fujisaki, N. Palmieri, C. Savoiu, Takeshi Nakanishi, O. Bracchi, J. Sandbank, G. Shapiro, Inna Sinuani, C. Volteau, Sandrine Lemoine, Isabel Rodríguez, Paloma Gallar, George A. Kaysen, Leonid Feldman, Roberto Minutolo, Aniana Oliet, P. Kyriazis, M. Prencipe, Daniele Marcelli, Albert Power, Coupel S., C. Mon, Ferruccio Conte, Yukiko Hasuike, Davide Medica, M. Kalymniou, J. Boldizsar, Anastasia Markaki, J. Kyriazis, Z. Straussova, Nikolina Bašić-Jukić, G. Conte, Vincenzo Panichi, Takayuki Kuragano, Len A. Usvyat, M. Ortiz, A. Belloi, P. Kes, A. Paris, E. Ivandic, Gabriel Mircescu, H. Tanaka, F. Colombo, Yosef S. Haviv, Masayoshi Nanami, E. Bruschetta, Ada Azar, Silvio Borrelli, Aileen Grassmann, A. Scalia, Maria Majernikova, J. Herrero, D. Hristea, Mana Yahiro, Massimiliano Migliori, C. Di Gioia, Liliana Garneata, Zhan Averbukh, V. Kissova, Peter Kotanko, and Laurent Juillard

Subjects
Transplantation, medicine.medical_specialty, business.industry, Inflammation, Protein energy wasting, medicine.disease_cause, Endocrinology, Nephrology, Internal medicine, medicine, medicine.symptom, business, Dialysis (biochemistry), Oxidative stress
Published
2014

5. SP126ACUTE KIDNEY INJURY AND REMISSION OF PROTEINURIA IN ADULT-ONSET MINIMAL CHANGE DISEASE; A MULTICENTER RETROSPECTIVE COHORT STUDY

Author

Maki Shinzawa, Takayuki Kuragano, Masaaki Izumi, Terumasa Hayashi, Megumu Fukunaga, Yasuyuki Nagasawa, Toshiki Moriyama, Katsuyuki Nagatoya, Yukiko Hasuike, Yoshitaka Isaka, Atsushi Yamauchi, Yoshiharu Tsubakihara, Takeshi Nakanishi, Kodo Tomida, and Ryohei Yamamoto

Subjects
Transplantation, medicine.medical_specialty, Proteinuria, Nephrology, business.industry, Internal medicine, Kidney injury, Medicine, Retrospective cohort study, Minimal change disease, medicine.symptom, business, medicine.disease
Published
2017

6. MP119EFFICACY OF STEROID STEROID THERAPY FOR IGA NEPHROPATHY THERAPY FOR IGA NEPHROPATHY

Author

Toshiki Moriyama, Katsuyuki Nagatoya, Maki Shinzawa, Yukiko Hasuike, Takayuki Kuragano, Rhouhei Yamamoto, Tatsuya Shouji, Kiyiko Yamamoto, Takeshi Nakanishi, Yasuyuki Nagasawa, Atsushi Yamauchi, Terumasa Hayashi, Yoshitaka Isaka, and Tomoko Kimura

Subjects
Transplantation, Steroid therapy, Nephrology, business.industry, medicine.medical_treatment, Immunology, medicine, business, medicine.disease, Steroid, Nephropathy
Published
2016

7. FP117PREVALENCE OF CANCER IN MEMBRANOUS NEPHROPATHY PATIENTS

Author

Yasuyuki Nagasawa, Takayuki Kuragano, Yukiko Hasuike, Aritoshi Kida, Sayuri Kawada, Yoshimasa Nanami, Tomoko Kimura, Takeshi Nakanishi, Kiyoko Yamamoto, and Mana Yahiro

Subjects
Transplantation, Pathology, medicine.medical_specialty, Membranous nephropathy, Nephrology, business.industry, medicine, Cancer, medicine.disease, business
Published
2015

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