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4 results on '"Takayuki Menjo"'

1. Nucleophilic Arylation of Halopurines Facilitated by Brønsted Acid in Fluoroalcohol

Author

Naoko Takenaga, Toshitaka Shoji, Takayuki Menjo, Akiko Hirai, Shohei Ueda, Kotaro Kikushima, Tomonori Hanasaki, and Toshifumi Dohi

Subjects
purine, nucleobase, aromatic substitution, arylation, fluoroalcohol, Organic chemistry, QD241-441
Abstract

Various aryl-substituted purine derivatives were synthesized through the direct arylation of halopurines with aromatic compounds, facilitated by the combination of triflic acid and fluoroalcohol. This metal-free method is complementary to conventional coupling reactions using metal catalysts and reagents for the syntheses of aryl-substituted purine analogues.

Published
2019
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2. Triflimide-Promoted Nucleophilic C-Arylation of Halopurines to Access N7-Substituted Purine Biaryls

Author

Kosuke Fukushima, Kotaro Kikushima, Tomonori Hanasaki, Naoko Takenaga, Toshifumi Dohi, Toshitaka Shoji, Yoichi Yamada, and Takayuki Menjo

Subjects
Purine, Steric effects, Heteroatom, Substituent, General Chemistry, General Medicine, Electrophilic aromatic substitution, Combinatorial chemistry, Nucleobase, chemistry.chemical_compound, Nucleophile, chemistry, Nucleophilic aromatic substitution, Drug Discovery
Abstract

Functionalized nucleobases are utilized in a wide range of fields; therefore, the development of new synthesis methods is essential for their continued application. With respect to the C6-arylation of halopurines, which possess a substituent at the N7-position, only a small number of successful cases have been reported, which is predominately a result of large steric hinderance effects. Herein, we report efficient and metal-free C6-arylations and SNAr reactions of N7-substituted chloropurines in aromatic and heteroatom nucleophiles promoted by triflimide (Tf2NH) in fluoroalcohol.

Published
2021
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3. Triflimide-Promoted Nucleophilic C-Arylation of Halopurines to Access N

Author

Toshitaka, Shoji, Kosuke, Fukushima, Takayuki, Menjo, Yoichi, Yamada, Tomonori, Hanasaki, Kotaro, Kikushima, Naoko, Takenaga, and Toshifumi, Dohi

Subjects
Cyclohexanones, Purines, Stereoisomerism, Antiviral Agents
Abstract

Functionalized nucleobases are utilized in a wide range of fields; therefore, the development of new synthesis methods is essential for their continued application. With respect to the C

Published
2021

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