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1. Increased RUNX3 expression mediates tumor‐promoting ability of human breast cancer‐associated fibroblasts

2. Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA

3. Isolated and repeated stroke-like episodes in a middle-aged man with a mitochondrial ND3 T10158C mutation: a case report

4. Aberrant RNA processing contributes to the pathogenesis of mitochondrial diseases in trans-mitochondrial mouse model carrying mitochondrial tRNALeu(UUR) with a pathogenic A2748G mutation

5. Mitochondria metabolomics reveals a role of β-nicotinamide mononucleotide metabolism in mitochondrial DNA replication

7. Catalytically inactive Cas9 impairs DNA replication fork progression to induce focal genomic instability

8. Chemical acetylation of mitochondrial transcription factor A occurs on specific lysine residues and affects its ability to change global DNA topology

9. The accessory subunit of human DNA polymerase γ is required for mitochondrial DNA maintenance and is able to stabilize the catalytic subunit

10. An overview of mammalian mitochondrial DNA replication mechanisms

11. List of Contributors

12. Epigenetic features of mitochondrial DNA

13. Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA

14. Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases II and II in vertebrate mitochondria

15. Mitochondrial DNA replication proceeds via a ‘bootlace’ mechanism involving the incorporation of processed transcripts

16. Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria

17. Mitochondrial single-stranded DNA binding protein is required for maintenance of mitochondrial DNA and 7S DNA but is not required for mitochondrial nucleoid organisation

18. Mammalian Mitochondrial DNA Replication Intermediates Are Essentially Duplex but Contain Extensive Tracts of RNA/DNA Hybrid

19. The accessory subunit of mitochondrial DNA polymerase γ determines the DNA content of mitochondrial nucleoids in human cultured cells

20. Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes

21. Suppression of mitochondrial transcription initiation complexes changes the balance of replication intermediates of mitochondrial DNA and reduces 7S DNA in cultured human cells

22. Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect

23. Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases

24. Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease

25. The pathogenic A4269G mutation in human mitochondrial tRNAIlealters the T-stem structure and decreases the binding affinity for elongation factor Tu

26. Wobble modification defect in tRNA disturbs codon-anticodon interaction in a mitochondrial disease

28. PGC-1β mediates adaptive chemoresistance associated with mitochondrial DNA mutations

29. Mitochondrial DNA Replication

30. Molecular Themes in DNA Replication

31. Analysis of mitochondrial DNA by two-dimensional agarose gel electrophoresis

32. Analysis of Mitochondrial DNA by Two-Dimensional Agarose Gel Electrophoresis

33. Analysis of replicating mitochondrial DNA by two-dimensional agarose gel electrophoresis

34. The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA

35. Analysis of Replicating Mitochondrial DNA by Two-Dimensional Agarose Gel Electrophoresis

36. Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand

39. Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone

41. Wobble modification defect suppresses translational activity of tRNAs with MERRF and MELAS mutations

42. The 7472insC mitochondrial DNA mutation impairs the synthesis and extent of aminoacylation of tRNASer(UCN) but not its structure or rate of turnover

43. A pathogenic point mutation reduces stability of mitochondrial mutant tRNA(Ile)

44. Modification defect at anticodon wobble nucleotide of mitochondrial tRNAs(Leu)(UUR) with pathogenic mutations of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes

45. Suppression of mitochondrial transcription initiation complexes changes the balance of replication intermediates of mitochondrial DNA and reduces 7S DNA in cultured human cells.

46. A novel mtDNA mutation determines sensitivity to cisplatin induced cancer cell death

47. 89 Analysis of extensive RNA/DNA hybrids in the replicating mammalian mitochondrial genome

48. Defect in modification at the anticodon wobble nucleotide of mitochondrial tRNALys with the MERRF encephalomyopathy pathogenic mutation

49. Involvement of DNA ligase III and ribonuclease H1 in mitochondrial DNA replication in cultured human cells

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