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30 results on '"Takemaru, Makoto"'

5. A case of polyneuropathy associated with diabetic ketoacidosis in new‐onset type 1 diabetes.

Author

Sada, Kokoro, Hidaka, Shuji, Takemaru, Makoto, Ueno, Daisuke, and Shibata, Hirotaka

Subjects
DIABETIC acidosis, TYPE 1 diabetes, POLYNEUROPATHIES, HYPOGLOSSAL nerve, FACIAL paralysis, DIABETIC neuropathies, LARYNGEAL nerve palsy
Abstract

Although diabetic peripheral neuropathy is the most common diabetic microangiopathic complication, several other neuropathy syndromes can occur in the context of diabetes. We describe a rare case of polyneuropathy associated with diabetic ketoacidosis in a patient with new‐onset type 1 diabetes. A 42‐year‐old man with diabetic ketoacidosis was admitted to our hospital with complications of respiratory and renal failure requiring mechanical ventilation and hemodialysis, respectively. After diabetic ketoacidosis improved from the critical state, he developed upper‐ and lower‐limb paralysis with sensory disturbances and pain, as well as right facial paralysis, left recurrent nerve paralysis, and left hypoglossal nerve paralysis. Autonomic nerve function was also impaired. As the pathophysiology, prevention, and treatment of polyneuropathy associated with diabetic ketoacidosis are unclear, the neurologic function of patients with diabetic ketoacidosis should be closely monitored. [ABSTRACT FROM AUTHOR]

Published
2022
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11. Clinical, epidemiological, and etiological studies of adult aseptic meningitis: a report of 12 cases of herpes simplex meningitis, and a comparison with cases of herpes simplex encephalitis

Author

Himeno, Takahiro, primary, Shiga, Yuji, additional, Takeshima, Shinichi, additional, Tachiyama, Keisuke, additional, Kamimura, Teppei, additional, Kono, Ryuhei, additional, Takemaru, Makoto, additional, Takeshita, Jun, additional, Shimoe, Yutaka, additional, and Kuriyama, Masaru, additional

Published
2018
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26. Relationship between white matter lesions and regional cerebral blood flow changes during longitudinal follow up in Alzheimer's disease.

Author

Hanaoka, Takuya, Kimura, Noriyuki, Aso, Yasuhiro, Takemaru, Makoto, Kimura, Yuki, Ishibashi, Masato, and Matsubara, Etsuro

Subjects
BRAIN, RADIOGRAPHY, BRAIN diseases, ALZHEIMER'S disease, CEREBRAL circulation, DIAGNOSTIC imaging, LONGITUDINAL method, MAGNETIC resonance imaging, COMPUTERS in medicine, QUESTIONNAIRES, STATISTICS, POSITRON emission tomography, DATA analysis, DATA analysis software, DESCRIPTIVE statistics
Abstract

Aim The aim of the present study was to evaluate the relationship between baseline white matter lesions ( WML) and changes in regional cerebral blood flow during longitudinal follow up of patients with Alzheimer's disease ( AD). Methods A total of 38 patients with AD were included in the study (16 men, 22 women; mean age 77.8 years). All patients were evaluated using the Mini- Mental State Examination and brain perfusion single-photon emission computed tomography at baseline with an approximately 2-year follow up. The patients were divided into two subgroups according to the presence of WML on magnetic resonance imaging. Single-photon emission computed tomography data were analyzed using a voxel-by-voxel group analysis with Statistical Parametric Mapping 8 and region of interest analysis using FineSRT. Changes in Mini- Mental State Examination scores and regional cerebral blood flow were analyzed using the Wilcoxon signed-rank test. Results Mean Mini- Mental State Examination scores in AD patients with WML significantly decreased from 19.4 ± 4.8 to 15.5 ± 6.5 ( P = 0.003). Statistical Parametric Mapping 8 and FineSRT analysis showed more severe and widespread regional cerebral blood flow reduction, mainly in the frontal and mesial temporal regions in AD patients with WML compared with those without WML. Conclusion Baseline WML could predict a rapid progression of cognitive and brain functional impairment during longitudinal follow up in AD. Geriatr Gerontol Int 2016; 16: 836-842. [ABSTRACT FROM AUTHOR]

Published
2016
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29. Acute Prevertebral Abscesses Caused by Bacterial-infected Traumatic Tooth Fractures.

Author

Matsunaga K, Takemaru M, Yamashiro K, Yoshihara-Hirata C, Inohara K, Shimoe Y, Tanaka A, Kuriyama M, and Takashiba S

Subjects
Abscess drug therapy, Aged, Anti-Bacterial Agents therapeutic use, Humans, Male, Peri-Implantitis complications, Periodontitis complications, Spinal Diseases drug therapy, Abscess etiology, Bacteremia complications, Spinal Diseases etiology, Tooth Fractures complications
Abstract

We report a case of acute prevertebral abscess caused by traumatic tooth fractures in a 77-year-old Japanese man. After being transferred to our hospital the patient was initially diagnosed with a neck hematoma; however, blood culture showed Streptococcus parasanguinis, an oral bacterium, and an MRI examination suggested prevertebral abscesses. Tooth fractures, severe periodontitis, and peri-implantitis with Streptococcus parasanguinis were observed. Antibiotics were administered and fractured teeth were extracted. The patient's condition then gradually improved. We concluded that bacteremia caused by traumatic tooth fractures induced the acute prevertebral abscesses., Competing Interests: No potential conflict of interest relevant to this article was reported.

Published
2019
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30. Induction of Genes Expressed in Endothelial Cells of the Corpus Callosum in the Chronic Cerebral Hypoperfusion Rat Model.

Author

Aso Y, Nakamura K, Kimura N, Takemaru M, Arakawa R, Fujiki M, Hirano T, Kumamoto T, and Matsubara E

Subjects
Animals, Brain Ischemia physiopathology, Chronic Disease, Corpus Callosum blood supply, Corpus Callosum pathology, Corpus Callosum physiopathology, Disease Models, Animal, Endothelial Cells metabolism, Endothelial Cells pathology, Gene Expression Profiling, Humans, Leukoencephalopathies pathology, Male, Neurons metabolism, Neurons pathology, Rats, Rats, Wistar, Brain Ischemia metabolism, Corpus Callosum metabolism, Leukoencephalopathies genetics, White Matter pathology
Abstract

Background: Cerebrovascular white matter lesions (WMLs) are associated with cognitive impairment in patients with subcortical vascular dementia. We performed a comprehensive gene expression analysis to elucidate genes associated with WML development in a chronic cerebral hypoperfusion rat model., Methods: Brains of rats with bilateral carotid ligation (2VO, n = 10) and sham-operated rats (n = 5-10/group) were removed on days 1, 7, or 28 after surgery. Total RNA isolated from the corpus callosum was evaluated by microarray analysis and quantitative reverse transcription-polymerase chain reaction., Results: On days 7 and 28, WMLs exhibited histologic changes. On day 7, 16 genes were differentially expressed between groups. mRNA levels of Ptprb, Kcnj8, Crispld2, Bcl6b, and Gja5 were differentially expressed in 2VO rats on day 7, but then returned to normal, whereas mRNA levels of Vwf and Trappc6a were upregulated after day 7. Immunohistochemistry showed that GJA5 and vWF were detected in endothelial cells, KCNJ8 in endothelial cells and astrocytes, CRISPLD2 in neurons and astrocytes, and TRAPPC6A in neurons., Conclusion: Our findings indicate novel genes that may be associated with WML development in the chronic cerebral hypoperfusion rat model, and suggest an important role of neurovascular dysfunction in the pathophysiology., (© 2016 S. Karger AG, Basel.)

Published
2017
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