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Single- and multi-photon spectra of pulsed γ -ray beams produced at 17, 34, and 40 MeV in the laser Compton scattering were measured with an 8” × 12” NaI(Tl) detector. By using the experimental single-photon spectra as the probability function of generating random numbers, response functions of the NaI(Tl) detector to j -fold photons ( j = 2, 3, 4 ...) were constructed. The least-square fits to the experimental multi-photon spectra by the Poisson distribution consisting of the response functions were made. The multi-photon spectra measured at 17 and 34 MeV follow the Poisson distribution. A quenching phenomenon of multi-photon spectra was observed for 40 MeV γ -rays as a result of the saturation at the photomultiplier tube of the NaI(Tl) detector. The original Poisson distributions were restored from the quenched spectra using a saturation curve in the form of y = a ⋅ x η with η =e − b x . We discuss the accuracy of photon-flux determination.

In this study we describe the construction of a system composed of thermally responsive molecules that can be induced to accumulate in tumor tissues by heating. EgX molecules consisting of an urea–benzene framework and oligoethylene glycol (OEG) functional groups with an emissive aminoquinoline formed nanoparticles (NPs) ∼10 nm in size at 23 °C with a fluorescence quantum yield of 7–10%. At higher temperatures, additional self-assembly occurred as a result of OEG dehydration, and the NPs grew to over 1000 nm in size; this was accompanied by low critical solution temperature behavior. EgXs accumulated in tumor tissues of mice at a body temperature of around 33–35 °C, an effect that was accelerated by external heating around the tumor to approximately 40 °C as a result of increased particle size and enhanced retention in tissue. These EgX NPs can serve as a tool for in vivo monitoring of tumor progression and response to treatment.

For development of the metal-free MRI contrast agents, we prepared the supra-molecular organic radical, TEMPO-UBD, carrying TEMPO radical, as well as the urea, alkyl group, and phenyl ring, which demonstrate self-assembly behaviors using noncovalent bonds in an aqueous solution. In addition, TEMPO-UBD has the tertiary amine and the oligoethylene glycol chains (OEGs) for the function of pH and thermal responsiveness. By dynamic light scattering and transmission electron microscopy imaging, the resulting self-assembly was seen to form the spherical nanoparticles 10-150 nm in size. On heating, interestingly, the nanoparticles showed a lower critical solution temperature (LCST) behavior having two-step variation. This double-LCST behavior is the first such example among the supra-molecules. To evaluate of the ability as MRI contrast agents, the values of proton ((1)H) longitudinal relaxivity (r1) were determined using MRI apparatus. In conditions below and above CAC at pH 7.0, the distinguishable r1 values were estimated to be 0.17 and 0.21 mM(-1) s(1), indicating the suppression of fast tumbling motion of TEMPO moiety in a nanoparticle. Furthermore, r1 values became larger in the order of pH 7.09.05.0. Those thermal and pH dependencies indicated the possibility of metal-fee MRI functional contrast agents in the future.

We synthesized (2,4-trifluoromethyl-7-N-bis(2,5,8,11-tetraoxatridecane-13-yl)-aminoquinoline) TFMAQ-diEg4, an emissive aminoquinoline derivative that incorporated two tetraethyleneglycol chains into an amino group. TFMAQ-diEg4 showed fluorescence and thermo-responsive properties accompanied by a lower critical solution temperature (LCST), due to the introduction of the oligoethylene glycol chain. This thermo-responsive LCST behavior occurred at the border of a cloud point. Below and above the cloud point, self-assemblies of 6-7-nm nanoparticles and ~2000-nm microparticles were observed, in vitro. In addition, TFMAQ-diEg4 showed a high solubility, over 20 mM for aqueous solution, in vivo, which not only prevented thrombosis but also allowed various examinations, such as single intravenous administration and intravenous drips. Intravenous administration of TFMAQ-diEg4, to tumor-bearing, mice led to the accumulation of the molecule in the tumor tissue, as observed by fluorescence imaging. A subset of mice was treated with local heat around their tumor tissue and an intravenous drip of TFMAQ-diEg4, which led to a high intensity of TFMAQ-diEg4 emission within the tumor tissue. Therefore, we revealed that TFMAQ-diEg4 was useful as a fluorescence probe with thermo-responsive properties.

In the past years, the Lattice Boltzmann Method (LBM) has been developed and applied to simulate single phase flow with a free surface. In this paper, the free-surface tracking algorithms are newly implemented in a multi-phase LBM model to expand a capability of LBM to simulate a complex behavior of fluid flow. The model was verified by standard dam-break (single-phase) and oil-slick (two-phase) experiments and were found to be in good agreement with the results.

The Lattice Boltzmann Method (LBM) has been developed as a new and robust numerical model to solve the fluid dynamics. In this study, we applied LBM for free surface flow, which Shallow-water approximation cannot provide accurate estimation. LBM was tested in some benchmark problems and laboratory experiment. The model results are in good agreement with dam-break experiment, including the movement of free surface of water body, splash against the upper wall, and a wave traveling back to the other side of the tank. Through the model validation, we found that LBM can be applied to simulate the complex behavior in tsunami wave front.