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156 results on '"Takeuchi, Hirohisa"'

4. Endoscopic full‐thickness resection for gastric submucosal tumors: Japanese multicenter prospective study.

Author

Shichijo, Satoki, Uedo, Noriya, Sawada, Atsushi, Hirasawa, Kingo, Takeuchi, Hirohisa, Abe, Nobutsugu, Miyaoka, Masaki, Yao, Kenshi, Dobashi, Akira, Sumiyama, Kazuki, Ishida, Tsukasa, Morita, Yoshinori, and Ono, Hiroyuki

Subjects
ENDOSCOPIC surgery, GASTRECTOMY, GASTROINTESTINAL stromal tumors, GASTRIC mucosa, LONGITUDINAL method, TUMOR surgery
Abstract

Objectives: Early gastric cancer endoscopic resection (ER) is prominent in Japan. However, evidence regarding ER of gastric submucosal tumors (SMT) is limited. This prospective multicenter phase II study investigated the efficacy and safety of endoscopic full‐thickness resection (EFTR) for gastric SMT. Methods: Endoscopic full‐thickness resection indication for gastric SMT was 11–30 mm, histologically proven or clinically suspicious (irregular margin, increasing size, or internal heterogeneity) gastrointestinal stromal tumors (GIST), with no ulceration and intraluminal growth type. The primary end‐point was the complete ER (ER0) rate, with a sample size of 42. Results: We enrolled 46 patients with 46 lesions between September 2020 and May 2023 at seven Japanese institutions. The mean ± SD (range) endoscopic tumor size was 18.8 ± 4.5 (11–28) mm. The tumor resection and defect closure times were 54 ± 26 (22–125) min and 33 ± 28 (12–186) min, respectively. A 100% ER0 was achieved in all 46 patients. The EFTR procedure was accomplished in all patients without surgical intervention. One patient had delayed perforation and was managed endoscopically. GIST accounted for 76% (n = 35) of the cases. R0, R1, and RX rates were 33 (77%), 3 (6.5%), and 7 (15%), respectively. Conclusion: Endoscopic full‐thickness resection for gastric SMT of 11–30 mm is efficacious. It warrants further validation in a large‐scale cohort study to determine the long‐term outcome of this treatment for patients with gastric GIST. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Endoscopic full‐thickness resection for gastric submucosal tumors: Japanese multicenter prospective study

Author

Shichijo, Satoki, primary, Uedo, Noriya, additional, Sawada, Atsushi, additional, Hirasawa, Kingo, additional, Takeuchi, Hirohisa, additional, Abe, Nobutsugu, additional, Miyaoka, Masaki, additional, Yao, Kenshi, additional, Dobashi, Akira, additional, Sumiyama, Kazuki, additional, Ishida, Tsukasa, additional, Morita, Yoshinori, additional, and Ono, Hiroyuki, additional

Published
2023
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12. Endoscopic resection for gastric submucosal tumors: Japanese multicenter retrospective study

Author

Shichijo, Satoki, primary, Abe, Nobutsugu, additional, Takeuchi, Hirohisa, additional, Ohata, Ken, additional, Minato, Yohei, additional, Hashiguchi, Kazutoshi, additional, Hirasawa, Kingo, additional, Kayaba, Shoichi, additional, Shinkai, Hirohiko, additional, Kobara, Hideki, additional, Yamashina, Takeshi, additional, Ishida, Tsukasa, additional, Chiba, Hideyuki, additional, Ono, Hiroyuki, additional, Mori, Hirohito, additional, and Uedo, Noriya, additional

Published
2022
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17. Endoscopic resection for gastric submucosal tumors: Japanese multicenter retrospective study.

Author

Shichijo, Satoki, Abe, Nobutsugu, Takeuchi, Hirohisa, Ohata, Ken, Minato, Yohei, Hashiguchi, Kazutoshi, Hirasawa, Kingo, Kayaba, Shoichi, Shinkai, Hirohiko, Kobara, Hideki, Yamashina, Takeshi, Ishida, Tsukasa, Chiba, Hideyuki, Ono, Hiroyuki, Mori, Hirohito, and Uedo, Noriya

Subjects
ENDOSCOPIC surgery, GASTRECTOMY, GASTROINTESTINAL stromal tumors, LAPAROSCOPIC surgery, TUMORS
Abstract

Objectives: Limited information is available on the efficacy and safety of endoscopic resection (ER) of gastric submucosal tumors (SMTs) in Japanese endoscopic practice where ER for gastric tumors is extremely popular. Methods: We conducted this study to elucidate the current scenario of ER for gastric SMTs in Japanese endoscopic practice. Patients (from 12 institutions) with gastric SMTs who underwent ER were enrolled from the first case until August 2020. Results: We enrolled 117 patients with 118 lesions. The number of patients who underwent ER increased over the years. The mean endoscopic tumor size was 20 ± 7.2 (8–40) mm. The growth type was primarily intraluminal (90%). The mean resection and wound closure times were 58 ± 38 (range, 12–254) min and 31 ± 41 (range, 3–330) min, respectively. Complete ER was achieved for 117 (99%) lesions. Full‐thickness resection rate was 44%; however, only 12 (10%) patients required abdominal paracentesis for decompression. Endoscopic treatments were completed in 115 (97%) lesions, while three lesions required conversions to laparoscopic surgery due to luminal collapse, uncontrolled bleeding, and difficulty in defect closure. Gastrointestinal stromal tumors were the most common pathology (74%). No recurrence was observed during the mean follow‐up period of 4.3 ± 2.9 years. The 5‐year overall survival rate was 98.9% (95% confidence interval 97.8–100%). Conclusion: Performance of ER for gastric SMTs is increasing in Japan. The technique seems feasible in Japanese endoscopic practice, warranting further validation in a prospective study. Watch a video of this article. [ABSTRACT FROM AUTHOR]

Published
2023
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30. High-temperature Magnetization Characteristics of Steels

Author

Yasuhiro Yogo, Takashi Ishikawa, Takeuchi Hirohisa, Tomonori Tajima, and Tsuyoshi Hattori

Subjects
010302 applied physics, Materials science, Condensed matter physics, Mechanical Engineering, Metals and Alloys, 02 engineering and technology, 01 natural sciences, 020501 mining & metallurgy, Magnetization, 0205 materials engineering, Mechanics of Materials, 0103 physical sciences, Materials Chemistry, Curie temperature
Published
2017

31. Laparoscopic lymph node dissection after endoscopic submucosal dissection: a novel and minimally invasive approach to treating early-stage gastric cancer

Author

Abe, Nobutsugu, Mori, Toshiyuki, Takeuchi, Hirohisa, Yoshida, Takashi, Ohki, Atsuko, Ueki, Hisayo, Yanagida, Osamu, Masaki, Tadahiko, Sugiyama, Masanori, and Atomi, Yutaka

Subjects
Lymphatic metastasis -- Care and treatment, Stomach cancer -- Care and treatment, Gastrectomy -- Risk factors, Cancer -- Care and treatment, Cancer -- Methods, Lymph nodes -- Surgery, Lymph nodes -- Methods, Health
Published
2005

34. Establishment of pathological quantitative method for determining undifferentiated component ratio in patients with differentiated/undifferentiated mixed-type early gastric cancer and clinical significance of this ratio

Author

Takeuchi, Hirohisa, primary, Abe, Nobutsugu, additional, Hashimoto, Yoshikazu, additional, Ooki, Atsuko, additional, Nagao, Gen, additional, Hirano, Kazuhiko, additional, Ookura, Yasuo, additional, Masaki, Tadahiko, additional, Mori, Toshiyuki, additional, and Sugiyama, Masanori, additional

Published
2017
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37. STK11p.F354L Germline Mutation in a Case of Multiple Gastrointestinal Tumors

Author

Kojima, Yohei, Ohtsuka, Kouki, Ishii, Shun, Aso, Nobuyoshi, Ohki, Atsuko, Hashimoto, Yoshikazu, Takeuchi, Hirohisa, Ohnishi, Hiroaki, and Abe, Nobutsugu

Abstract

Serine/threonine kinase 11 (STK11) is known as a critical tumor-suppressor gene that is frequently mutated in a broad spectrum of human cancers. Among these, the p.F354L mutation of STK11has been identified in sporadic colon or lung cancer cases. Here, we report the case of a 75-year-old male patient who underwent surgical treatment for multiple tumors of the gastrointestinal system. Genetic mutations were screened in all resected samples, including duodenal high-grade adenoma, gastric high-grade adenoma, rectal adenocarcinoma, and liver metastasis of rectal adenocarcinoma, by next-generation sequencing for mutational hotspots involving 50 oncogenes and tumor suppressor genes. The characteristic hamartomatous polyp of Peutz-Jeghers syndrome was not detected in any tumor specimen. However, all samples as well as the normal rectal mucosa harbored the genetic mutation p.F354L in STK11. In addition, somatic mutations coexisted in the tumor samples, including KRASp.A146T, TP53p.G238X, and APCp.T1556fs in the duodenal adenoma; TP53p.G238Y and APCp.T1556fs in the gastric adenoma; and TP53p.R282W in the rectal adenocarcinoma and metastatic liver cancer. No somatic mutation was detected in the normal rectal mucosa as a control sample. To our knowledge, this is the first report of an STK11germline mutation in a patient with multiple tumors of the gastrointestinal tract.

Published
2020
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38. Strain-induced boundary migration of carbon steel at high temperatures

Author

Takashi Ishikawa, Koukichi Nakanishi, Noritoshi Iwata, Takeuchi Hirohisa, and Yasuhiro Yogo

Subjects
In situ, Materials science, Carbon steel, Mechanical Engineering, Metallurgy, Metals and Alloys, Recrystallization (metallurgy), engineering.material, Condensed Matter Physics, Microstructure, Grain growth, Mechanics of Materials, engineering, Dynamic recrystallization, General Materials Science, Observation method, Boundary migration
Abstract

The rate of strain-induced boundary migration (SIBM), which appears during small strains in carbon steel under the critical strain for dynamic recrystallization, was measured through in situ observation at high temperatures. The rate of SIBM measured is much higher than the rate of grain growth without strain. The in situ observation method confirms that SIBM can be initiated by strains as small as 0.015.

Published
2009

39. MRT letter: In situ observation method for microstructural changes of steel during hot deformation

Author

Takeuchi Hirohisa, Yasuhiro Yogo, Takashi Ishikawa, Noritoshi Iwata, Koukichi Nakanishi, and Kouji Tanaka

Subjects
In situ, Histology, Materials science, Strain (chemistry), fungi, Metallurgy, Recrystallization (metallurgy), Tensile strain, Microstructure, Medical Laboratory Technology, Grain boundary, Observation method, sense organs, Anatomy, Deformation (engineering), Instrumentation
Abstract

We report on the result of an in situ method for observing microstructural changes during hot deformation. The observation of microstructural changes of steel at 1,473 K under tensile strain is demonstrated using the reported method. The development of deformed structures and the formation of a new grain boundary, which subsequently moved with increased strain, were clearly observed. The effectiveness of this method was confirmed by the results of several examples. © 2009 Wiley-Liss, Inc.

Published
2009

40. Successful treatment of large adenoma extending close to the papilla in the duodenum by laparoscopy-assisted pancreas-sparing duodenectomy

Author

Abe, Nobutsugu, primary, Hashimoto, Yoshikazu, additional, Kawaguchi, Shouhei, additional, Shimoyama, Hayato, additional, Kojima, Youhei, additional, Yoshimoto, Eri, additional, Kondo, Eri, additional, Ohki, Atsuko, additional, Takeuchi, Hirohisa, additional, Nagao, Gen, additional, Suzuki, Yutaka, additional, Masaki, Tadahiko, additional, Mori, Toshiyuki, additional, and Sugiyama, Masanori, additional

Published
2016
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41. Series: Diagnosis at a Glance

Author

Saraya, Takeshi, primary, Shimoda, Masafumi, additional, Ogawa, Yukari, additional, Tanaka, Yasutaka, additional, Kojima, Koichiro, additional, Takeuchi, Hirohisa, additional, and Takizawa, Hajime, additional

Published
2016
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42. Xenopericardial roll graft replacement for infectious pseudoaneurysms and graft infections of the aorta

Author

Kubota, Hiroshi, primary, Endo, Hidehito, additional, Noma, Mio, additional, Ishii, Hikaru, additional, Tsuchiya, Hiroshi, additional, Yoshimoto, Akihiro, additional, Takahashi, Yu, additional, Inaba, Yusuke, additional, Nishino, Yoshifumi, additional, Nunokawa, Masao, additional, Hosoi, Yutaka, additional, Ikezoe, Tooru, additional, Nemoto, Masaru, additional, Makino, Yoshihisa, additional, Nemoto, Yoko, additional, Matsukura, Mitsuru, additional, Sugiyama, Masanori, additional, Abe, Nobutsugu, additional, Takeuchi, Hirohisa, additional, Nagao, Gen, additional, Kondo, Eri, additional, Yanagida, Osamu, additional, Yoshino, Hideaki, additional, and Sudo, Kenichi, additional

Published
2015
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43. Laparoscopy‐assisted transduodenal excision of superficial non‐ampullary duodenal epithelial tumors

Author

Abe, Nobutsugu, primary, Takeuchi, Hirohisa, additional, Hashimoto, Yoshikazu, additional, Yoshimoto, Eri, additional, Kojima, Youhei, additional, Ohki, Atsuko, additional, Nagao, Gen, additional, Suzuki, Yutaka, additional, Horiai, Shinichi, additional, Mizuno, Hideaki, additional, Masaki, Tadahiko, additional, Mori, Toshiyuki, additional, and Sugiyama, Masanori, additional

Published
2015
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