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1. ARDS clinical practice guideline 2021

Author

Nakashima, Takuro, Masunaga, Aiko, Tanaka, Aiko, Inoue, Akihiko, Higashi, Akiko, Tanikawa, Atsushi, Ujiro, Atsushi, Takayama, Chihiro, Kasugai, Daisuke, Kawakami, Daisuke, Ueno, Daisuke, Satoh, Daizoh, Kai, Shinichi, Ota, Kohei, Hagiwara, Yoshihiro, Hamaguchi, Jun, Fujii, Ryo, Hongo, Takashi, Kishihara, Yuki, Masunaga, Naohisa, Yamamoto, Ryohei, Okazaki, Satoru Robert, Uchimido, Ryo, Terayama, Tetsuro, Hokari, Satoshi, Sakamoto, Hitoshi, Dongli, Nakataki, Emiko, Tabata, Erina, Okazawa, Seisuke, Kotajima, Futoshi, Ishimaru, Go, Hoshino, Haruhiko, Yoshida, Hideki, Iwai, Hidetaka, Nakagawa, Hiroaki, Sugimura, Hiroko, Narumiya, Hiromichi, Okano, Hiromu, Nakamura, Hiroshi, Sugimoto, Hiroshi, Hashimoto, Hiroyuki, Ito, Hiroyuki, Dote, Hisashi, Imahase, Hisashi, Sato, Hitoshi, Katsurada, Masahiro, Osawa, Ichiro, Kamei, Jun, Maki, Jun, Sugihara, Jun, Takeshita, Jun, Fujimoto, Junichi, Ishikawa, Junichi, Kosaka, Junko, Shibata, Junpei, Hashimoto, Katsuhiko, Nakano, Yasushi, Kikuyama, Kazuki, Shimizu, Kazushige, Okada, Kazuya, Kawano, Keishi, Anan, Keisuke, Ota, Keisuke, Kano, Ken-ichi, Asano, Kengo, Hondo, Kenichi, Ishii, Kenji, Fujita, Kensuke, Ogawa, Kenta, Ito, Kentaro, Tokunaga, Kentaro, Ishii, Kenzo, Kusumoto, Kohei, Takimoto, Kohei, Yamada, Kohei, Naito, Koichi, Yamashita, Koichi, Yoshinaga, Koichi, Yamauchi, Kota, Murata, Maki, Konda, Makiko, Hamamoto, Manabu, Aga, Masaharu, Kashiura, Masahiro, Ishikawa, Masami, Ozaki, Masayuki, Kono, Michihiko, Kyo, Michihito, Hayashi, Minoru, Abe, Mitsuhiro, Sato, Mitsunori, Sakai, Mizu, Kainuma, Motoshi, Tominaga, Naoki, Iguchi, Naoya, Nakagawa, Natsuki, Aoki, Nobumasa, Nishioka, Norihiro, Miyashita, Norihisa, Seki, Nozomu, Ikebe, Ryo, Imai, Ryosuke, Tate, Ryota, Sato, Ryuhei, Miyakawa, Sachiko, Kazuma, Satoshi, Nakano, Satoshi, Tetsumoto, Satoshi, Yoshimura, Satoshi, Yoshitake, Shigenori, Hoshi, Shin-etsu, Ohki, Shingo, Sato, Shintaro, Yoshihiro, Shodai, Ihara, Shoichi, Yamamoto, Shota, Koide, Shunichi, Kimata, Shunsuke, Saito, Shunsuke, Yasuo, Shunsuke, Sekine, Shusuke, Mimuro, Soichiro, Wada, Soichiro, Sugimura, Sosuke, Ishihara, Tadashi, Kaneko, Tadashi, Nagato, Tadashi, Maruhashi, Takaaki, Tamura, Takahiro, Ohno, Takanori, Ichiyama, Takashi, Niwa, Takashi, Ueji, Takashi, Ogura, Takayuki, Kawasaki, Takeshi, Tanaka, Takeshi, Umegaki, Takeshi, Furukawa, Taku, Omura, Taku, Nagao, Takumi, Mayumi, Takuya, Taniguchi, Takuya, Yoshida, Takuya, Shimatani, Tatsutoshi, Murata, Teppei, Sato, Tetsuya, Sawamoto, Tohru, Koukei, Yoshifumi, Takehara, Tomohiro, Ueda, Tomomi, Katsuta, Tomoya, Nishino, Tomoya, Yokoyama, Toshiki, Higashijima, Ushio, Iwanaga, Wataru, Inoue, Yasushi, Iwashita, Yoshiaki, Yamada, Yoshie, Kubota, Yoshifumi, Suido, Yoshihiro, Tomioka, Yoshihiro, Fujimoto, Yoshihisa, Fujita, Yoshihito, Yamaguchi, Yoshikazu, Nakamura, Yoshimi, Abe, Yoshinobu, Eguchi, Yoshitomo, Oshima, Yoshiyasu, Fukuda, Yosuke, Iwasaki, Yudai, Yasufuku, Yuichi, Shono, Yuji, Nakatani, Yuka, Nakamori, Yuki, Ito, Yukie, Tanabe, Yuko, Nagamine, Yusuke, Nakamura, Yuta, Kurihara, Yutaro, Tasaka, Sadatomo, Ohshimo, Shinichiro, Takeuchi, Muneyuki, Yasuda, Hideto, Ichikado, Kazuya, Tsushima, Kenji, Egi, Moritoki, Hashimoto, Satoru, Shime, Nobuaki, Saito, Osamu, Matsumoto, Shotaro, Nango, Eishu, Okada, Yohei, Hayashi, Kenichiro, Sakuraya, Masaaki, Nakajima, Mikio, Okamori, Satoshi, Miura, Shinya, Fukuda, Tatsuma, Kamo, Tetsuro, Yatabe, Tomoaki, Norisue, Yasuhiro, Aoki, Yoshitaka, Iizuka, Yusuke, Kondo, Yutaka, Narita, Chihiro, Taito, Shunsuke, Hayashi, Takuya, Terayama, Takero, Kataoka, Jun, Nishimura, Tetsuro, Yonekura, Hiroshi, Ando, Koichi, Yoshida, Takuo, Masuyama, Tomoyuki, and Sanui, Masamitsu

Published
2022
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3. Development and validation of the predictive risk of death model for adult patients admitted to intensive care units in Japan: an approach to improve the accuracy of healthcare quality measures

Author

Endo, Hideki, Uchino, Shigehiko, Hashimoto, Satoru, Aoki, Yoshitaka, Hashiba, Eiji, Hatakeyama, Junji, Hayakawa, Katsura, Ichihara, Nao, Irie, Hiromasa, Kawasaki, Tatsuya, Kumasawa, Junji, Kurosawa, Hiroshi, Nakamura, Tomoyuki, Ohbe, Hiroyuki, Okamoto, Hiroshi, Shigemitsu, Hidenobu, Tagami, Takashi, Takaki, Shunsuke, Takimoto, Kohei, Uchida, Masatoshi, and Miyata, Hiroaki

Published
2021
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4. Conventional risk prediction models fail to accurately predict mortality risk among patients with coronavirus disease 2019 in intensive care units: a difficult time to assess clinical severity and quality of care

Author

Endo, Hideki, Ohbe, Hiroyuki, Kumasawa, Junji, Uchino, Shigehiko, Hashimoto, Satoru, Aoki, Yoshitaka, Asaga, Takehiko, Hashiba, Eiji, Hatakeyama, Junji, Hayakawa, Katsura, Ichihara, Nao, Irie, Hiromasa, Kawasaki, Tatsuya, Kurosawa, Hiroshi, Nakamura, Tomoyuki, Okamoto, Hiroshi, Shigemitsu, Hidenobu, Takaki, Shunsuke, Takimoto, Kohei, Uchida, Masatoshi, Uchimido, Ryo, and Miyata, Hiroaki

Published
2021
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6. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J‐SSCG 2016)

Author

Nishida, Osamu, Ogura, Hiroshi, Egi, Moritoki, Fujishima, Seitaro, Hayashi, Yoshiro, Iba, Toshiaki, Imaizumi, Hitoshi, Inoue, Shigeaki, Kakihana, Yasuyuki, Kotani, Joji, Kushimoto, Shigeki, Masuda, Yoshiki, Matsuda, Naoyuki, Matsushima, Asako, Nakada, Taka‐aki, Nakagawa, Satoshi, Nunomiya, Shin, Sadahiro, Tomohito, Shime, Nobuaki, Yatabe, Tomoaki, Hara, Yoshitaka, Hayashida, Kei, Kondo, Yutaka, Sumi, Yuka, Yasuda, Hideto, Aoyama, Kazuyoshi, Azuhata, Takeo, Doi, Kent, Doi, Matsuyuki, Fujimura, Naoyuki, Fuke, Ryota, Fukuda, Tatsuma, Goto, Koji, Hasegawa, Ryuichi, Hashimoto, Satoru, Hatakeyama, Junji, Hayakawa, Mineji, Hifumi, Toru, Higashibeppu, Naoki, Hirai, Katsuki, Hirose, Tomoya, Ide, Kentaro, Kaizuka, Yasuo, Kanʼo, Tomomichi, Kawasaki, Tatsuya, Kuroda, Hiromitsu, Matsuda, Akihisa, Matsumoto, Shotaro, Nagae, Masaharu, Onodera, Mutsuo, Ohnuma, Tetsu, Oshima, Kiyohiro, Saito, Nobuyuki, Sakamoto, So, Sakuraya, Masaaki, Sasano, Mikio, Sato, Norio, Sawamura, Atsushi, Shimizu, Kentaro, Shirai, Kunihiro, Takei, Tetsuhiro, Takeuchi, Muneyuki, Takimoto, Kohei, Taniguchi, Takumi, Tatsumi, Hiroomi, Tsuruta, Ryosuke, Yama, Naoya, Yamakawa, Kazuma, Yamashita, Chizuru, Yamashita, Kazuto, Yoshida, Takeshi, Tanaka, Hiroshi, and Oda, Shigeto

Published
2018
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7. Additional file 1 of Development and validation of the predictive risk of death model for adult patients admitted to intensive care units in Japan: an approach to improve the accuracy of healthcare quality measures

Author

Endo, Hideki, Shigehiko Uchino, Hashimoto, Satoru, Aoki, Yoshitaka, Hashiba, Eiji, Hatakeyama, Junji, Hayakawa, Katsura, Ichihara, Nao, Irie, Hiromasa, Kawasaki, Tatsuya, Kumasawa, Junji, Kurosawa, Hiroshi, Nakamura, Tomoyuki, Ohbe, Hiroyuki, Okamoto, Hiroshi, Hidenobu Shigemitsu, Tagami, Takashi, Takaki, Shunsuke, Takimoto, Kohei, Uchida, Masatoshi, and Miyata, Hiroaki

Abstract

Additional file 1: Table S1 Coefficients of models 1 and 2. R code for fitting models 1, 2, and 3. Fig. S1 EWMA charts for the 44 ICUs (recalibrated with the method used in model 3). Sequential admissions are presented on the x-axis. The red lines show the exponentially weighted moving average of mortality, with starting points of the average mortality in each ICU during the study period and with a weight of 0.005 on the latest data. The light and dark green lines are the control limits representing two- and three-standard deviations, respectively. EWMA, exponentially weighted moving average; ICU, intensive care unit

Published
2021
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9. ARDS clinical practice guideline 2021

Author

Tasaka, Sadatomo, Ohshimo, Shinichiro, Takeuchi, Muneyuki, Yasuda, Hideto, Ichikado, Kazuya, Tsushima, Kenji, Egi, Moritoki, Hashimoto, Satoru, Shime, Nobuaki, Saito, Osamu, Matsumoto, Shotaro, Nango, Eishu, Okada, Yohei, Hayashi, Kenichiro, Sakuraya, Masaaki, Nakajima, Mikio, Okamori, Satoshi, Miura, Shinya, Fukuda, Tatsuma, Ishihara, Tadashi, Kamo, Tetsuro, Yatabe, Tomoaki, Norisue, Yasuhiro, Aoki, Yoshitaka, Iizuka, Yusuke, Kondo, Yutaka, Narita, Chihiro, Kawakami, Daisuke, Okano, Hiromu, Takeshita, Jun, Anan, Keisuke, Okazaki, Satoru Robert, Taito, Shunsuke, Hayashi, Takuya, Mayumi, Takuya, Terayama, Takero, Kubota, Yoshifumi, Abe, Yoshinobu, Iwasaki, Yudai, Kishihara, Yuki, Kataoka, Jun, Nishimura, Tetsuro, Yonekura, Hiroshi, Ando, Koichi, Yoshida, Takuo, Masuyama, Tomoyuki, Sanui, Masamitsu, Nakashima, Takuro, Masunaga, Aiko, Tanaka, Aiko, Inoue, Akihiko, Higashi, Akiko, Tanikawa, Atsushi, Ujiro, Atsushi, Takayama, Chihiro, Kasugai, Daisuke, Kawakami, Daisuke, Ueno, Daisuke, Satoh, Daizoh, Kai, Shinichi, Ota, Kohei, Hagiwara, Yoshihiro, Hamaguchi, Jun, Fujii, Ryo, Hongo, Takashi, Kishihara, Yuki, Masunaga, Naohisa, Yamamoto, Ryohei, Okazaki, Satoru Robert, Uchimido, Ryo, Terayama, Tetsuro, Hokari, Satoshi, Sakamoto, Hitoshi, Dongli, Nakataki, Emiko, Tabata, Erina, Okazawa, Seisuke, Kotajima, Futoshi, Ishimaru, Go, Hoshino, Haruhiko, Yoshida, Hideki, Iwai, Hidetaka, Nakagawa, Hiroaki, Sugimura, Hiroko, Narumiya, Hiromichi, Okano, Hiromu, Nakamura, Hiroshi, Sugimoto, Hiroshi, Hashimoto, Hiroyuki, Ito, Hiroyuki, Dote, Hisashi, Imahase, Hisashi, Sato, Hitoshi, Katsurada, Masahiro, Osawa, Ichiro, Kamei, Jun, Maki, Jun, Sugihara, Jun, Takeshita, Jun, Fujimoto, Junichi, Ishikawa, Junichi, Kosaka, Junko, Shibata, Junpei, Hashimoto, Katsuhiko, Nakano, Yasushi, Kikuyama, Kazuki, Shimizu, Kazushige, Okada, Kazuya, Kawano, Keishi, Anan, Keisuke, Ota, Keisuke, Kano, Ken-ichi, Asano, Kengo, Hondo, Kenichi, Ishii, Kenji, Fujita, Kensuke, Ogawa, Kenta, Ito, Kentaro, Tokunaga, Kentaro, Ishii, Kenzo, Kusumoto, Kohei, Takimoto, Kohei, Yamada, Kohei, Naito, Koichi, Yamashita, Koichi, Yoshinaga, Koichi, Yamauchi, Kota, Murata, Maki, Konda, Makiko, Hamamoto, Manabu, Aga, Masaharu, Kashiura, Masahiro, Ishikawa, Masami, Ozaki, Masayuki, Kono, Michihiko, Kyo, Michihito, Hayashi, Minoru, Abe, Mitsuhiro, Sato, Mitsunori, Sakai, Mizu, Kainuma, Motoshi, Tominaga, Naoki, Iguchi, Naoya, Nakagawa, Natsuki, Aoki, Nobumasa, Nishioka, Norihiro, Miyashita, Norihisa, Seki, Nozomu, Ikebe, Ryo, Imai, Ryosuke, Tate, Ryota, Sato, Ryuhei, Miyakawa, Sachiko, Kazuma, Satoshi, Nakano, Satoshi, Tetsumoto, Satoshi, Yoshimura, Satoshi, Yoshitake, Shigenori, Hoshi, Shin-etsu, Ohki, Shingo, Sato, Shintaro, Yoshihiro, Shodai, Ihara, Shoichi, Yamamoto, Shota, Koide, Shunichi, Kimata, Shunsuke, Saito, Shunsuke, Yasuo, Shunsuke, Sekine, Shusuke, Mimuro, Soichiro, Wada, Soichiro, Sugimura, Sosuke, Ishihara, Tadashi, Kaneko, Tadashi, Nagato, Tadashi, Maruhashi, Takaaki, Tamura, Takahiro, Ohno, Takanori, Ichiyama, Takashi, Niwa, Takashi, Ueji, Takashi, Ogura, Takayuki, Kawasaki, Takeshi, Tanaka, Takeshi, Umegaki, Takeshi, Furukawa, Taku, Omura, Taku, Nagao, Takumi, Mayumi, Takuya, Taniguchi, Takuya, Yoshida, Takuya, Shimatani, Tatsutoshi, Murata, Teppei, Sato, Tetsuya, Sawamoto, Tohru, Koukei, Yoshifumi, Takehara, Tomohiro, Ueda, Tomomi, Katsuta, Tomoya, Nishino, Tomoya, Yokoyama, Toshiki, Higashijima, Ushio, Iwanaga, Wataru, Inoue, Yasushi, Iwashita, Yoshiaki, Yamada, Yoshie, Kubota, Yoshifumi, Suido, Yoshihiro, Tomioka, Yoshihiro, Fujimoto, Yoshihisa, Fujita, Yoshihito, Yamaguchi, Yoshikazu, Nakamura, Yoshimi, Abe, Yoshinobu, Eguchi, Yoshitomo, Oshima, Yoshiyasu, Fukuda, Yosuke, Iwasaki, Yudai, Yasufuku, Yuichi, Shono, Yuji, Nakatani, Yuka, Nakamori, Yuki, Ito, Yukie, Tanabe, Yuko, Nagamine, Yusuke, Nakamura, Yuta, and Kurihara, Yutaro

Abstract

The joint committee of the Japanese Society of Intensive Care Medicine/Japanese Respiratory Society/Japanese Society of Respiratory Care Medicine on ARDS Clinical Practice Guideline has created and released the ARDS Clinical Practice Guideline 2021.

Published
2022
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10. Supplemental Material, Appendix1_Ethics_committee_071618 - The Treatment Intensity of Anticoagulant Therapy for Patients With Sepsis-Induced Disseminated Intravascular Coagulation and Outcomes: A Multicenter Cohort Study

Author

Kudo, Daisuke, Mineji Hayakawa, Iijima, Hiroaki, Yamakawa, Kazuma, Shinjiro Saito, Shigehiko Uchino, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, and Mayumi, Toshihiko

Subjects
FOS: Clinical medicine, Cardiology, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental Material, Appendix1_Ethics_committee_071618 for The Treatment Intensity of Anticoagulant Therapy for Patients With Sepsis-Induced Disseminated Intravascular Coagulation and Outcomes: A Multicenter Cohort Study by Daisuke Kudo, Mineji Hayakawa, Hiroaki Iijima, Kazuma Yamakawa, Shinjiro Saito, Shigehiko Uchino, Yusuke Iizuka, Masamitsu Sanui, Kohei Takimoto, Toshihiko Mayumi, and JSEPTIC DIC Study Investigators in Clinical and Applied Thrombosis/Hemostasis

Published
2019
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11. Supplemental Material, Supplemental_figure_3 - The Treatment Intensity of Anticoagulant Therapy for Patients With Sepsis-Induced Disseminated Intravascular Coagulation and Outcomes: A Multicenter Cohort Study

Author

Kudo, Daisuke, Mineji Hayakawa, Iijima, Hiroaki, Yamakawa, Kazuma, Shinjiro Saito, Shigehiko Uchino, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, and Mayumi, Toshihiko

Subjects
FOS: Clinical medicine, Cardiology, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental Material, Supplemental_figure_3 for The Treatment Intensity of Anticoagulant Therapy for Patients With Sepsis-Induced Disseminated Intravascular Coagulation and Outcomes: A Multicenter Cohort Study by Daisuke Kudo, Mineji Hayakawa, Hiroaki Iijima, Kazuma Yamakawa, Shinjiro Saito, Shigehiko Uchino, Yusuke Iizuka, Masamitsu Sanui, Kohei Takimoto, Toshihiko Mayumi, and JSEPTIC DIC Study Investigators in Clinical and Applied Thrombosis/Hemostasis

Published
2019
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12. Supplemental Material, CATHAppendix2_List_authors_082418_(1) - The Treatment Intensity of Anticoagulant Therapy for Patients With Sepsis-Induced Disseminated Intravascular Coagulation and Outcomes: A Multicenter Cohort Study

Author

Kudo, Daisuke, Mineji Hayakawa, Iijima, Hiroaki, Yamakawa, Kazuma, Shinjiro Saito, Shigehiko Uchino, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, and Mayumi, Toshihiko

Subjects
FOS: Clinical medicine, Cardiology, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental Material, CATHAppendix2_List_authors_082418_(1) for The Treatment Intensity of Anticoagulant Therapy for Patients With Sepsis-Induced Disseminated Intravascular Coagulation and Outcomes: A Multicenter Cohort Study by Daisuke Kudo, Mineji Hayakawa, Hiroaki Iijima, Kazuma Yamakawa, Shinjiro Saito, Shigehiko Uchino, Yusuke Iizuka, Masamitsu Sanui, Kohei Takimoto, Toshihiko Mayumi, and JSEPTIC DIC Study Investigators in Clinical and Applied Thrombosis/Hemostasis

Published
2019
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13. rhTM and mortality in sepsis-induced DIC

Author

Hayakawa, Mineji, Yamakawa, Kazuma, Saito, Shinjiro, Uchino, Shigehiko, Kudo, Daisuke, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Ono, Kota, and Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group

Subjects
sepsis, coagulation abnormality, thrombomodulin, mortality, disseminated intravascular coagulation
Abstract

Recombinant human soluble thrombomodulin (rhTM) is a novel class of anticoagulants for treating disseminated intravascular coagulation (DIC). Although rhTM is widely used in clinical settings throughout Japan, there is limited clinical evidence supporting the use of rhTM in patients with sepsis-induced DIC. Furthermore, rhTM is not approved for DIC treatment in other countries. This study aimed to clarify the survival benefits of rhTM administration in critically ill patients. Data from 3,195 consecutive adult patients who were admitted to 42 intensive care units for the treatment of severe sepsis or septic shock between January 2011 and December 2013 were retrospectively analysed, and 1,784 patients were diagnosed with DIC based on the scoring algorithm from the Japanese Association for Acute Medicine DIC (n = 645, rhTM group; n = 1,139, control group). Propensity score matching created 452 matched pairs, and logistic regression analysis revealed a significant association between rhTM administration and lower in-hospital all-cause mortality in the propensity score-matched groups (odds ratio, 0.757; 95% CI, 0.574-0.999, P = 0.049). Inverse probability of treatment weighted and quintile-stratified analyses also revealed significant associations between rhTM administration and lower in-hospital all-cause mortality. Survival time in the propensity score-matched rhTM group was significantly longer than that in the propensity score-matched control group (hazard ratio, 0.781; 95% CI, 0.624-0.977, P = 0.03). Bleeding complications were not more frequent in the rhTM groups. In conclusion, this study demonstrated that rhTM administration is associated with reduced in-hospital all-cause mortality among patients with sepsis-induced DIC.

Published
2016

15. Nationwide registry of sepsis patients in Japan focused on disseminated intravascular coagulation 2011-2013

Author

1000010374282, Hayakawa, Mineji, 1000050597507, Yamakawa, Kazuma, Saito, Shinjiro, Uchino, Shigehiko, 1000030455844, Kudo, Daisuke, Iizuka, Yusuke, 1000030424039, Sanui, Masamitsu, Takimoto, Kohei, 1000090281071, Mayumi, Toshihiko, 1000010374282, Hayakawa, Mineji, 1000050597507, Yamakawa, Kazuma, Saito, Shinjiro, Uchino, Shigehiko, 1000030455844, Kudo, Daisuke, Iizuka, Yusuke, 1000030424039, Sanui, Masamitsu, Takimoto, Kohei, 1000090281071, and Mayumi, Toshihiko

Published
2018

16. [Dataset]Nationwide registry of sepsis patients in Japan focused on disseminated intravascular coagulation 2011–2013

Author

1000010374282, Hayakawa, Mineji, 1000050597507, Yamakawa, Kazuma, Saito, Shinjiro, Uchino, Shigehiko, 1000030455844, Kudo, Daisuke, Iizuka, Yusuke, 1000030424039, Sanui, Masamitsu, Takimoto, Kohei, 1000090281071, Mayumi, Toshihiko, 1000010374282, Hayakawa, Mineji, 1000050597507, Yamakawa, Kazuma, Saito, Shinjiro, Uchino, Shigehiko, 1000030455844, Kudo, Daisuke, Iizuka, Yusuke, 1000030424039, Sanui, Masamitsu, Takimoto, Kohei, 1000090281071, and Mayumi, Toshihiko

Published
2018

18. The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2016 (J-SSCG 2016)

Author

Nishida, Osamu, primary, Ogura, Hiroshi, additional, Egi, Moritoki, additional, Fujishima, Seitaro, additional, Hayashi, Yoshiro, additional, Iba, Toshiaki, additional, Imaizumi, Hitoshi, additional, Inoue, Shigeaki, additional, Kakihana, Yasuyuki, additional, Kotani, Joji, additional, Kushimoto, Shigeki, additional, Masuda, Yoshiki, additional, Matsuda, Naoyuki, additional, Matsushima, Asako, additional, Nakada, Taka-aki, additional, Nakagawa, Satoshi, additional, Nunomiya, Shin, additional, Sadahiro, Tomohito, additional, Shime, Nobuaki, additional, Yatabe, Tomoaki, additional, Hara, Yoshitaka, additional, Hayashida, Kei, additional, Kondo, Yutaka, additional, Sumi, Yuka, additional, Yasuda, Hideto, additional, Aoyama, Kazuyoshi, additional, Azuhata, Takeo, additional, Doi, Kent, additional, Doi, Matsuyuki, additional, Fujimura, Naoyuki, additional, Fuke, Ryota, additional, Fukuda, Tatsuma, additional, Goto, Koji, additional, Hasegawa, Ryuichi, additional, Hashimoto, Satoru, additional, Hatakeyama, Junji, additional, Hayakawa, Mineji, additional, Hifumi, Toru, additional, Higashibeppu, Naoki, additional, Hirai, Katsuki, additional, Hirose, Tomoya, additional, Ide, Kentaro, additional, Kaizuka, Yasuo, additional, Kan’o, Tomomichi, additional, Kawasaki, Tatsuya, additional, Kuroda, Hiromitsu, additional, Matsuda, Akihisa, additional, Matsumoto, Shotaro, additional, Nagae, Masaharu, additional, Onodera, Mutsuo, additional, Ohnuma, Tetsu, additional, Oshima, Kiyohiro, additional, Saito, Nobuyuki, additional, Sakamoto, So, additional, Sakuraya, Masaaki, additional, Sasano, Mikio, additional, Sato, Norio, additional, Sawamura, Atsushi, additional, Shimizu, Kentaro, additional, Shirai, Kunihiro, additional, Takei, Tetsuhiro, additional, Takeuchi, Muneyuki, additional, Takimoto, Kohei, additional, Taniguchi, Takumi, additional, Tatsumi, Hiroomi, additional, Tsuruta, Ryosuke, additional, Yama, Naoya, additional, Yamakawa, Kazuma, additional, Yamashita, Chizuru, additional, Yamashita, Kazuto, additional, Yoshida, Takeshi, additional, Tanaka, Hiroshi, additional, and Oda, Shigeto, additional

Published
2018
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19. Institutional Variations in the Treatment Intensity of Anticoagulant Therapy for Patients with Sepsis-Induced Disseminated Intravascular Coagulation and Outcomes: A Multicenter Cohort Study

Author

Kudo, Daisuke, primary, Hayakawa, Mineji, additional, Iijima, Hiroaki, additional, Yamakawa, Kazuma, additional, Saito, Shinjiro, additional, Uchino, Shigehiko, additional, Iizuka, Yusuke, additional, Sanui, Masamitsu, additional, Takimoto, Kohei, additional, and Mayumi, Toshihiko, additional

Published
2018
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20. Additional file 1: Table S1. of Characteristics, treatments, and outcomes of severe sepsis of 3195 ICU-treated adult patients throughout Japan during 2011â 2013

Author

Mineji Hayakawa, Shinjiro Saito, Shigehiko Uchino, Yamakawa, Kazuma, Kudo, Daisuke, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Azuhata, Takeo, Ito, Fumihito, Shodai Yoshihiro, Hayakawa, Katsura, Nakashima, Tsuyoshi, Ogura, Takayuki, Noda, Eiichiro, Nakamura, Yoshihiko, Sekine, Ryosuke, Yoshikawa, Yoshiaki, Sekino, Motohiro, Ueno, Keiko, Okuda, Yuko, Watanabe, Masayuki, Tampo, Akihito, Saito, Nobuyuki, Kitai, Yuya, Takahashi, Hiroki, Kobayashi, Iwao, Kondo, Yutaka, Matsunaga, Wataru, Nachi, Sho, Miike, Toru, Takahashi, Hiroshi, Takauji, Shuhei, Umakoshi, Kensuke, Todaka, Takafumi, Kodaira, Hiroshi, Kohkichi Andoh, Kasai, Takehiko, Iwashita, Yoshiaki, Arai, Hideaki, Murata, Masato, Yamane, Masahiro, Shiga, Kazuhiro, and Hori, Naoto

Abstract

Epidemiological information from previous reports after 2005. (DOC 48 kb)

Published
2016
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21. Low-dose immunoglobulin G is not associated with mortality in patients with sepsis and septic shock

Author

Iizuka, Yusuke, primary, Sanui, Masamitsu, additional, Sasabuchi, Yusuke, additional, Lefor, Alan Kawarai, additional, Hayakawa, Mineji, additional, Saito, Shinjiro, additional, Uchino, Shigehiko, additional, Yamakawa, Kazuma, additional, Kudo, Daisuke, additional, Takimoto, Kohei, additional, Mayumi, Toshihiko, additional, Azuhata, Takeo, additional, Ito, Fumihito, additional, Yoshihiro, Shodai, additional, Hayakawa, Katsura, additional, Nakashima, Tsuyoshi, additional, Ogura, Takayuki, additional, Noda, Eiichiro, additional, Nakamura, Yoshihiko, additional, Sekine, Ryosuke, additional, Yoshikawa, Yoshiaki, additional, Sekino, Motohiro, additional, Ueno, Keiko, additional, Okuda, Yuko, additional, Watanabe, Masayuki, additional, Tampo, Akihito, additional, Saito, Nobuyuki, additional, Kitai, Yuya, additional, Takahashi, Hiroki, additional, Kobayashi, Iwao, additional, Kondo, Yutaka, additional, Matsunaga, Wataru, additional, Nachi, Sho, additional, Miike, Toru, additional, Takahashi, Hiroshi, additional, Takauji, Shuhei, additional, Umakoshi, Kensuke, additional, Todaka, Takafumi, additional, Kodaira, Hiroshi, additional, Andoh, Kohkichi, additional, Kasai, Takehiko, additional, Iwashita, Yoshiaki, additional, Arai, Hideaki, additional, Murata, Masato, additional, Yamane, Masahiro, additional, Shiga, Kazuhiro, additional, and Hori, Naoto, additional

Published
2017
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23. Antithrombin Supplementation and Mortality in Sepsis-Induced Disseminated Intravascular Coagulation

Author

Hayakawa, Mineji, primary, Kudo, Daisuke, additional, Saito, Shinjiro, additional, Uchino, Shigehiko, additional, Yamakawa, Kazuma, additional, Iizuka, Yusuke, additional, Sanui, Masamitsu, additional, Takimoto, Kohei, additional, Mayumi, Toshihiko, additional, Ono, Kota, additional, Azuhata, Takeo, additional, Ito, Fumihito, additional, Yoshihiro, Shodai, additional, Hayakawa, Katsura, additional, Nakashima, Tsuyoshi, additional, Ogura, Takayuki, additional, Noda, Eiichiro, additional, Nakamura, Yoshihiko, additional, Sekine, Ryosuke, additional, Yoshikawa, Yoshiaki, additional, Sekino, Motohiro, additional, Ueno, Keiko, additional, Okuda, Yuko, additional, Watanabe, Masayuki, additional, Tampo, Akihito, additional, Saito, Nobuyuki, additional, Kitai, Yuya, additional, Takahashi, Hiroki, additional, Kobayashi, Iwao, additional, Kondo, Yutaka, additional, Matsunaga, Wataru, additional, Nachi, Sho, additional, Miike, Toru, additional, Takahashi, Hiroshi, additional, Takauji, Shuhei, additional, Umakoshi, Kensuke, additional, Todaka, Takafumi, additional, Kodaira, Hiroshi, additional, Andoh, Kohkichi, additional, Kasai, Takehiko, additional, Iwashita, Yoshiaki, additional, Arai, Hideaki, additional, Murata, Masato, additional, Yamane, Masahiro, additional, Shiga, Kazuhiro, additional, and Hori, Naoto, additional

Published
2016
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24. Antithrombin Supplementation and Mortality in Sepsis-Induced Disseminated Intravascular Coagulation : A Multicenter Retrospective Observational Study

Author

Hayakawa, Mineji, Kudo, Daisuke, Saito, Shinjiro, Uchino, Shigehiko, Yamakawa, Kazuma, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Ono, Kota, Azuhata, Takeo, Ito, Fumihito, Yoshihiro, Shodai, Hayakawa, Katsura, Nakashima, Tsuyoshi, Ogura, Takayuki, Noda, Eiichiro, Nakamura, Yoshihiko, Sekine, Ryosuke, Yoshikawa, Yoshiaki, Sekino, Motohiro, Ueno, Keiko, Okuda, Yuko, Watanabe, Masayuki, Tampo, Akihito, Saito, Nobuyuki, Kitai, Yuya, Takahashi, Hiroki, Kobayashi, Iwao, Kondo, Yutaka, Matsunaga, Wataru, Nachi, Sho, Miike, Toru, Takahashi, Hiroshi, Takauji, Shuhei, Umakoshi, Kensuke, Todaka, Takafumi, Kodaira, Hiroshi, Andoh, Kohkichi, Kasai, Takehiko, Iwashita, Yoshiaki, Arai, Hideaki, Murata, Masato, Yamane, Masahiro, Shiga, Kazuhiro, Hori, Naoto, Hayakawa, Mineji, Kudo, Daisuke, Saito, Shinjiro, Uchino, Shigehiko, Yamakawa, Kazuma, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Ono, Kota, Azuhata, Takeo, Ito, Fumihito, Yoshihiro, Shodai, Hayakawa, Katsura, Nakashima, Tsuyoshi, Ogura, Takayuki, Noda, Eiichiro, Nakamura, Yoshihiko, Sekine, Ryosuke, Yoshikawa, Yoshiaki, Sekino, Motohiro, Ueno, Keiko, Okuda, Yuko, Watanabe, Masayuki, Tampo, Akihito, Saito, Nobuyuki, Kitai, Yuya, Takahashi, Hiroki, Kobayashi, Iwao, Kondo, Yutaka, Matsunaga, Wataru, Nachi, Sho, Miike, Toru, Takahashi, Hiroshi, Takauji, Shuhei, Umakoshi, Kensuke, Todaka, Takafumi, Kodaira, Hiroshi, Andoh, Kohkichi, Kasai, Takehiko, Iwashita, Yoshiaki, Arai, Hideaki, Murata, Masato, Yamane, Masahiro, Shiga, Kazuhiro, and Hori, Naoto

Abstract

Supplemental doses of antithrombin (AT) are widely used to treat sepsis-induced disseminated intravascular coagulation (DIC) in Japan. However, evidence on the benefits of AT supplementation for DIC is insufficient. This multicenter retrospective observational study aimed to clarify the effect of AT supplementation on sepsis-induced DIC using propensity score analyses. Data from 3,195 consecutive adult patients admitted to 42 intensive care units for severe sepsis treatment were retrospectively analyzed; 1,784 patients were diagnosed with DIC (n=715, AT group; n=1,069, control group). Inverse probability of treatment-weighted propensity score analysis indicated a statistically significant association between AT supplementation and lower in-hospital all-cause mortality (n=1,784, odds ratio [95% confidence intervals]: 0.748 [0.572-0.978], P=0.034). However, quintile-stratified propensity score analysis (n=1,784, odds ratio: 0.823 [0.646-1.050], P=0.117) and propensity score matching analysis (461 matching pairs, odds ratio: 0.855 [0.649-1.125], P=0.263) did not show this association. In the early days after intensive care unit admission, the survival rate was statistically higher in the propensity score-matched AT group than in the propensity score-matched control group (P=0.007). In DIC patients without concomitant heparin administration, similar results were observed. In conclusion, AT supplementation may be associated with reduced in-hospital all-cause mortality in patients with sepsis-induced DIC. However, the statistical robustness of this connection was not strong. In addition, although the number of transfusions needed in patients with AT supplementation increased, severe bleeding complications did not.

Published
2016

25. Characteristics, treatments, and outcomes of severe sepsis of 3195 ICU-treated adult patients throughout Japan during 2011-2013

Author

Hayakawa, Mineji, Saito, Shinjiro, Uchino, Shigehiko, Yamakawa, Kazuma, Kudo, Daisuke, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Azuhata, Takeo, Ito, Fumihito, Yoshihiro, Shodai, Hayakawa, Katsura, Nakashima, Tsuyoshi, Ogura, Takayuki, Noda, Eiichiro, Nakamura, Yoshihiko, Sekine, Ryosuke, Yoshikawa, Yoshiaki, Sekino, Motohiro, Ueno, Keiko, Okuda, Yuko, Watanabe, Masayuki, Tampo, Akihito, Saito, Nobuyuki, Kitai, Yuya, Takahashi, Hiroki, Kobayashi, Iwao, Kondo, Yutaka, Matsunaga, Wataru, Nachi, Sho, Miike, Toru, Takahashi, Hiroshi, Takauji, Shuhei, Umakoshi, Kensuke, Todaka, Takafumi, Kodaira, Hiroshi, Andoh, Kohkichi, Kasai, Takehiko, Iwashita, Yoshiaki, Arai, Hideaki, Murata, Masato, Yamane, Masahiro, Shiga, Kazuhiro, Hori, Naoto, Hayakawa, Mineji, Saito, Shinjiro, Uchino, Shigehiko, Yamakawa, Kazuma, Kudo, Daisuke, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Azuhata, Takeo, Ito, Fumihito, Yoshihiro, Shodai, Hayakawa, Katsura, Nakashima, Tsuyoshi, Ogura, Takayuki, Noda, Eiichiro, Nakamura, Yoshihiko, Sekine, Ryosuke, Yoshikawa, Yoshiaki, Sekino, Motohiro, Ueno, Keiko, Okuda, Yuko, Watanabe, Masayuki, Tampo, Akihito, Saito, Nobuyuki, Kitai, Yuya, Takahashi, Hiroki, Kobayashi, Iwao, Kondo, Yutaka, Matsunaga, Wataru, Nachi, Sho, Miike, Toru, Takahashi, Hiroshi, Takauji, Shuhei, Umakoshi, Kensuke, Todaka, Takafumi, Kodaira, Hiroshi, Andoh, Kohkichi, Kasai, Takehiko, Iwashita, Yoshiaki, Arai, Hideaki, Murata, Masato, Yamane, Masahiro, Shiga, Kazuhiro, and Hori, Naoto

Abstract

Severe sepsis is a major concern in the intensive care unit (ICU), although there is very little epidemiological information regarding severe sepsis in Japan. This study evaluated 3195 patients with severe sepsis in 42 ICUs throughout Japan. The patients with severe sepsis had a mean age of 70 +/- 15 years and a mean Acute Physiology and Chronic Health Evaluation II score of 23 +/- 9. The estimated survival rates at 28 and 90 days after ICU admission were 73.6 and 56.3 %, respectively.

Published
2016

26. Recombinant human soluble thrombomodulin and mortality in sepsis-induced disseminated intravascular coagulation : a multicentre retrospective study

Author

Hayakawa, Mineji, Yamakawa, Kazuma, Saito, Shinjiro, Uchino, Shigehiko, Kudo, Daisuke, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Ono, Kota, Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group, Hayakawa, Mineji, Yamakawa, Kazuma, Saito, Shinjiro, Uchino, Shigehiko, Kudo, Daisuke, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Ono, Kota, and Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group

Abstract

Recombinant human soluble thrombomodulin (rhTM) is a novel class of anticoagulants for treating disseminated intravascular coagulation (DIC). Although rhTM is widely used in clinical settings throughout Japan, there is limited clinical evidence supporting the use of rhTM in patients with sepsis-induced DIC. Furthermore, rhTM is not approved for DIC treatment in other countries. This study aimed to clarify the survival benefits of rhTM administration in critically ill patients. Data from 3,195 consecutive adult patients who were admitted to 42 intensive care units for the treatment of severe sepsis or septic shock between January 2011 and December 2013 were retrospectively analysed, and 1,784 patients were diagnosed with DIC based on the scoring algorithm from the Japanese Association for Acute Medicine DIC (n = 645, rhTM group; n = 1,139, control group). Propensity score matching created 452 matched pairs, and logistic regression analysis revealed a significant association between rhTM administration and lower in-hospital all-cause mortality in the propensity score-matched groups (odds ratio, 0.757; 95% CI, 0.574-0.999, P = 0.049). Inverse probability of treatment weighted and quintile-stratified analyses also revealed significant associations between rhTM administration and lower in-hospital all-cause mortality. Survival time in the propensity score-matched rhTM group was significantly longer than that in the propensity score-matched control group (hazard ratio, 0.781; 95% CI, 0.624-0.977, P = 0.03). Bleeding complications were not more frequent in the rhTM groups. In conclusion, this study demonstrated that rhTM administration is associated with reduced in-hospital all-cause mortality among patients with sepsis-induced DIC.

Published
2016

27. Characteristics, treatments, and outcomes of severe sepsis of 3195 ICU-treated adult patients throughout Japan during 2011-2013

Author

1000010374282, Hayakawa, Mineji, Saito, Shinjiro, Uchino, Shigehiko, Yamakawa, Kazuma, 1000030455844, Kudo, Daisuke, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Azuhata, Takeo, Ito, Fumihito, Yoshihiro, Shodai, Hayakawa, Katsura, Nakashima, Tsuyoshi, Ogura, Takayuki, Noda, Eiichiro, Nakamura, Yoshihiko, Sekine, Ryosuke, Yoshikawa, Yoshiaki, 1000040380927, Sekino, Motohiro, Ueno, Keiko, Okuda, Yuko, Watanabe, Masayuki, 1000080531524, Tampo, Akihito, Saito, Nobuyuki, Kitai, Yuya, Takahashi, Hiroki, Kobayashi, Iwao, Kondo, Yutaka, Matsunaga, Wataru, 1000030452155, Nachi, Sho, Miike, Toru, Takahashi, Hiroshi, Takauji, Shuhei, Umakoshi, Kensuke, Todaka, Takafumi, Kodaira, Hiroshi, Andoh, Kohkichi, Kasai, Takehiko, Iwashita, Yoshiaki, Arai, Hideaki, Murata, Masato, Yamane, Masahiro, Shiga, Kazuhiro, Hori, Naoto, 1000010374282, Hayakawa, Mineji, Saito, Shinjiro, Uchino, Shigehiko, Yamakawa, Kazuma, 1000030455844, Kudo, Daisuke, Iizuka, Yusuke, Sanui, Masamitsu, Takimoto, Kohei, Mayumi, Toshihiko, Azuhata, Takeo, Ito, Fumihito, Yoshihiro, Shodai, Hayakawa, Katsura, Nakashima, Tsuyoshi, Ogura, Takayuki, Noda, Eiichiro, Nakamura, Yoshihiko, Sekine, Ryosuke, Yoshikawa, Yoshiaki, 1000040380927, Sekino, Motohiro, Ueno, Keiko, Okuda, Yuko, Watanabe, Masayuki, 1000080531524, Tampo, Akihito, Saito, Nobuyuki, Kitai, Yuya, Takahashi, Hiroki, Kobayashi, Iwao, Kondo, Yutaka, Matsunaga, Wataru, 1000030452155, Nachi, Sho, Miike, Toru, Takahashi, Hiroshi, Takauji, Shuhei, Umakoshi, Kensuke, Todaka, Takafumi, Kodaira, Hiroshi, Andoh, Kohkichi, Kasai, Takehiko, Iwashita, Yoshiaki, Arai, Hideaki, Murata, Masato, Yamane, Masahiro, Shiga, Kazuhiro, and Hori, Naoto

Abstract

Severe sepsis is a major concern in the intensive care unit (ICU), although there is very little epidemiological information regarding severe sepsis in Japan. This study evaluated 3195 patients with severe sepsis in 42 ICUs throughout Japan. The patients with severe sepsis had a mean age of 70 +/- 15 years and a mean Acute Physiology and Chronic Health Evaluation II score of 23 +/- 9. The estimated survival rates at 28 and 90 days after ICU admission were 73.6 and 56.3 %, respectively.

Published
2016

29. Characteristics, treatments, and outcomes of severe sepsis of 3195 ICU-treated adult patients throughout Japan during 2011–2013

Author

Hayakawa, Mineji, primary, Saito, Shinjiro, additional, Uchino, Shigehiko, additional, Yamakawa, Kazuma, additional, Kudo, Daisuke, additional, Iizuka, Yusuke, additional, Sanui, Masamitsu, additional, Takimoto, Kohei, additional, Mayumi, Toshihiko, additional, Azuhata, Takeo, additional, Ito, Fumihito, additional, Yoshihiro, Shodai, additional, Hayakawa, Katsura, additional, Nakashima, Tsuyoshi, additional, Ogura, Takayuki, additional, Noda, Eiichiro, additional, Nakamura, Yoshihiko, additional, Sekine, Ryosuke, additional, Yoshikawa, Yoshiaki, additional, Sekino, Motohiro, additional, Ueno, Keiko, additional, Okuda, Yuko, additional, Watanabe, Masayuki, additional, Tampo, Akihito, additional, Saito, Nobuyuki, additional, Kitai, Yuya, additional, Takahashi, Hiroki, additional, Kobayashi, Iwao, additional, Kondo, Yutaka, additional, Matsunaga, Wataru, additional, Nachi, Sho, additional, Miike, Toru, additional, Takahashi, Hiroshi, additional, Takauji, Shuhei, additional, Umakoshi, Kensuke, additional, Todaka, Takafumi, additional, Kodaira, Hiroshi, additional, Andoh, Kohkichi, additional, Kasai, Takehiko, additional, Iwashita, Yoshiaki, additional, Arai, Hideaki, additional, Murata, Masato, additional, Yamane, Masahiro, additional, Shiga, Kazuhiro, additional, and Hori, Naoto, additional

Published
2016
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32. Gingyo Gedokusan vs Oseltamivir for the Treatment of Uncomplicated Influenza and Influenza-like illness : An Open-label Prospective Study

Author

Iwata, Kentaro, primary, Igarashi, Wataru, additional, Honjo, Midori, additional, Nishimoto, Takashi, additional, Shinya, Kyoko, additional, Makino, Akiko, additional, Mitani, Kazuo, additional, Tatsumi, Yoshiko, additional, Ninomiya, Hiroyuki, additional, Higasa, Kumi, additional, Usuki, Seiichiro, additional, Kagawa, Hiroki, additional, Uchida, Daisuke, additional, Takimoto, Kohei, additional, Suganaga, Rei, additional, Matsuo, Hiroo, additional, Oba, Yuichiro, additional, Horigome, Mami, additional, Oka, Hideaki, additional, Ohji, Goh, additional, Abe, Yasuhisa, additional, Yoshida, Hiroyuki, additional, Kinoshita, Shohiro, additional, and Hirai, Midori, additional

Published
2013
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33. Non-nosocomial healthcare-associated left-sided Pseudomonas aeruginosa endocarditis: a case report and literature review.

Author

Hideharu Hagiya, Takeshi Tanaka, Kohei Takimoto, Hisao Yoshida, Norihisa Yamamoto, Yukihiro Akeda, Kazunori Tomono, Hagiya, Hideharu, Tanaka, Takeshi, Takimoto, Kohei, Yoshida, Hisao, Yamamoto, Norihisa, Akeda, Yukihiro, and Tomono, Kazunori

Subjects
INFECTIVE endocarditis, PSEUDOMONAS aeruginosa infections, TRANSESOPHAGEAL echocardiography, MEROPENEM, TOBRAMYCIN, COMBINATION drug therapy, THERAPEUTICS
Abstract

Background: With the development of invasive medical procedures, an increasing number of healthcare-associated infective endocarditis cases have been reported. In particular, non-nosocomial healthcare-associated infective endocarditis in outpatients with recent medical intervention has been increasingly identified.Case Presentation: A 66-year-old man with diabetes mellitus and a recent history of intermittent urethral self-catheterization was admitted due to a high fever. Repeated blood cultures identified Pseudomonas aeruginosa, and transesophageal echocardiography uncovered a new-onset severe aortic regurgitation along with a vegetative valvular structure. The patient underwent emergency aortic valve replacement surgery and was successfully treated with 6 weeks of high-dose meropenem and tobramycin. Historically, most cases of P. aeruginosa endocarditis have occurred in the right side of the heart and in outpatients with a history of intravenous drug abuse. In the case presented, the repeated manipulations of the urethra may have triggered the infection. Our literature review for left-sided P. aeruginosa endocarditis showed that non-nosocomial infection accounted for nearly half of the cases and resulted in fatal outcomes as often as nosocomial cases. A combination therapy with anti-pseudomonal beta-lactams or carbapenems and aminoglycosides may be the preferable treatment. Medical treatment alone may be effective, and surgical treatment should be carefully considered.Conclusions: We presented a rare case of native aortic valve endocarditis caused by P. aeruginosa. This case illustrates the importance of identifying the causative pathogen(s), especially for outpatients with a recent history of medical procedures. [ABSTRACT FROM AUTHOR]

Published
2016
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36. The Treatment Intensity of Anticoagulant Therapy for Patients With Sepsis-Induced Disseminated Intravascular Coagulation and Outcomes: A Multicenter Cohort Study.

Author

Kudo D, Hayakawa M, Iijima H, Yamakawa K, Saito S, Uchino S, Iizuka Y, Sanui M, Takimoto K, and Mayumi T

Subjects
Aged, Anticoagulants adverse effects, Disease-Free Survival, Female, Hemorrhage chemically induced, Hemorrhage mortality, Humans, Male, Middle Aged, Retrospective Studies, Survival Rate, Anticoagulants administration & dosage, Disseminated Intravascular Coagulation drug therapy, Disseminated Intravascular Coagulation mortality, Hospital Mortality, Intensive Care Units, Sepsis drug therapy, Sepsis mortality
Abstract

We examined the institutional variations in anticoagulation therapy for sepsis-induced disseminated intravascular coagulation (DIC) and their effects on patient outcomes. This post hoc analysis of a cohort study included 3195 patients with severe sepsis across 42 intensive care units. To evaluate differences in the intensity of anticoagulation therapy, the proportion of patients receiving anticoagulation therapy and the total number of patients with sepsis-induced DIC were compared. Predicted in-hospital mortality for each patient was calculated using logistic regression analysis. To evaluate survival outcomes, the actual/mean predicted in-hospital mortality ratio in each institution was calculated. Thirty-eight institutions with 2897 patients were included. Twenty-five institutions treated 60% to 100% (high-intensity institutions), while the rest treated 0% to 50% (low-intensity institutions) of patients with sepsis-induced DIC having anticoagulant therapy. Every 10-unit increase in the intensity of anticoagulant therapy was associated with lower in-hospital mortality (odds ratio: 0.904). A higher number of high-intensity institutions (compared to low-intensity institutions) had lower in-hospital mortality and fewer bleeding events than predicted. In conclusion, institutional variations existed in the use of anticoagulation therapy in patients with sepsis-induced DIC. High-intensity anticoagulation therapy was associated with better outcomes.

Published
2019
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