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1. A Multiparametric Volumetric Quantitative Ultrasound Imaging Technique for Soft Tissue Characterization

Author

Deeba, Farah, Schneider, Caitlin, Mohammed, Shahed, Honarvar, Mohammad, Lobo, Julio, Tam, Edward, Salcudean, Septimiu, and Rohling, Robert

Subjects
Physics - Medical Physics
Abstract

Quantitative ultrasound (QUS) offers a non-invasive and objective way to quantify tissue health. We recently presented a spatially adaptive regularization method for reconstruction of a single QUS parameter, limited to a two dimensional region. That proof-of-concept study showed that regularization using homogeneity prior improves the fundamental precision-resolution trade-off in QUS estimation. Based on the weighted regularization scheme, we now present a multiparametric 3D weighted QUS (3D QUS)imaging system, involving the reconstruction of three QUS parameters: attenuation coefficient estimate (ACE), integrated backscatter coefficient (IBC) and effective scatterer diameter (ESD). With the phantom studies, we demonstrate that our proposed method accurately reconstructs QUS parameters, resulting in high reconstruction contrast and therefore improved diagnostic utility. Additionally, the proposed method offers the ability to analyze the spatial distribution of QUS parameters in 3D, which allows for superior tissue characterization. We apply a three-dimensional total variation regularization method for the volumetric QUS reconstruction. The 3D regularization involving N planes results in a high QUS estimation precision, with an improvement of standard deviation over the theoretical rate achievable by compounding N independent realizations. In the in vivo liver study, we demonstrate the advantage of adopting a multiparametric approach over the single parametric counterpart, where a simple quadratic discriminant classifier using feature combination of three QUS parameters was able to attain a perfect classification performance to distinguish between normal and fatty liver cases.

Published
2021
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4. Ledipasvir/sofosbuvir for treatment of hepatitis C virus in sofosbuvir-experienced, NS5A treatment-naïve patients: Findings from two randomized trials.

Author

Tam, Edward, Luetkemeyer, Anne F, Mantry, Parvez S, Satapathy, Sanjaya K, Ghali, Peter, Kang, Minhee, Haubrich, Richard, Shen, Xianlin, Ni, Liyun, Camus, Gregory, Copans, Amanda, Rossaro, Lorenzo, Guyer, Bill, Brown, Robert S, and RESCUE and ACTG A5348 study investigators

Subjects
RESCUE and ACTG A5348 study investigators, Humans, Hepacivirus, Hepatitis C, Chronic, HIV Infections, Liver Cirrhosis, Headache, Fatigue, Benzimidazoles, Fluorenes, Ribavirin, Uridine Monophosphate, Antiviral Agents, Pregnancy, Adult, Aged, Middle Aged, Female, Male, Coinfection, Sofosbuvir, Sustained Virologic Response, HCV, HIV, ledipasvir, sofosbuvir, treatment-experienced, Gastroenterology & Hepatology, Clinical Sciences
Abstract

Background & aimsWe report data from two similarly designed studies that evaluated the efficacy, safety, and optimal duration of ledipasvir/sofosbuvir (LDV/SOF) ± ribavirin (RBV) for retreatment of chronic hepatitis C virus (HCV) in individuals who failed to achieve sustained virological response (SVR) with prior SOF-based, non-NS5A inhibitor-containing regimens.MethodsThe RESCUE study enrolled HCV mono-infected adults with genotype (GT) 1 or 4. Non-cirrhotic participants were randomized to 12 weeks of LDV/SOF or LDV/SOF + RBV. Compensated cirrhotic participants were randomized to LDV/SOF + RBV (12 weeks) or LDV/SOF (24 weeks). The AIDS Clinical Trials Group A5348 study randomized genotype 1 adults with HCV/HIV co-infection to LDV/SOF + RBV (12 weeks) or LDV/SOF (24 weeks). Both studies used SVR at 12 weeks post-treatment (SVR12) as the primary endpoint.ResultsIn the RESCUE study, 82 participants were randomized and treated, and all completed treatment. Overall, SVR12 was 88% (72/82); 81-100% in non-cirrhotic participants treated with LDV/SOF or LDV/SOF + RBV for 12 weeks and 80-92% in cirrhotic participants treated with LDV/SOF + RBV for 12 weeks or LDV/SOF for 24 weeks. Adverse events (AEs), mostly mild-to-moderate in severity, were experienced by 78% of participants, with headache and fatigue most frequently reported. One serious AE, not related to treatment, was observed. No premature discontinuations of study drug, or deaths occurred. In the A5348 study, seven participants were randomized (cirrhotic n = 1; GT1a n = 5) and all attained SVR12, with no serious AEs or premature discontinuations.ConclusionsIn this SOF-experienced, NS5A inhibitor-naïve population, which included participants with cirrhosis or HCV/HIV co-infection, high SVR12 rates were achieved.

Published
2018

7. SWTV-ACE: Spatially Weighted Regularization Based Attenuation Coefficient Estimation Method for Hepatic Steatosis Detection

Author

Deeba, Farah, Schneider, Caitlin, Mohammed, Shahed, Honarvar, Mohammad, Tam, Edward, Salcudean, Septimiu, Rohling, Robert, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Shen, Dinggang, editor, Liu, Tianming, editor, Peters, Terry M., editor, Staib, Lawrence H., editor, Essert, Caroline, editor, Zhou, Sean, editor, Yap, Pew-Thian, editor, and Khan, Ali, editor

Published
2019
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8. Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

Author

Gadano, Adrian, Martins, Marcelo, Angus, Peter, Bate, John, Danta, Mark, George, Jacob, Hodge, Alexander, Kontorinis, Nickolas, Roberts, Stuart, Sanagapalli, Santosh, Skoien, Richard, Thompson, Alexander, Zekry, Amany, Stauber, Rudolf, Trauner, Michael, Moreno, Christophe, Reynaert, Hendrik, Verbeke, Len, Silva, Mario Reis Alvares da, Parise, Edison, Oliveira, Claudia Pinto Marques Souza de, Araujo, Roberta Chaves, Martinelli, Ana de Lourdes Candolo, Borman, Meredith, Chandok, Natasha, Elkhashab, Magdy, Fraser, Hughie, Kaita, Kelly, Ma, Mang, Marotta, Paul, Ramji, Alnoor, Tam, Edward, Yoshida, Eric, Swain, Mark, Sebastiani, Giada, Petrunia, Denis, Abergel, Armando, Anty, Rodolphe, Bourlière, Marc, Boursier, Jérôme, Bureau, Christophe, Castera, Laurent, Habersetzer, François, Hézode, Christophe, Ledinghen, Victor De, Leroy, Vincent, Loustaud-Ratti, Véronique, Mathurin, Philippe, Pol, Stanislas, Zoulim, Fabien, Hinrichsen, Holger, Ingiliz, Patrick, Lammert, Frank, Manns, Michael, Schattenberg, Jörn, Schiefke, Ingolf, Trautwein, Christian, Zeuzem, Stefan, Hui, Aric, Li, King-Kong, Wong, Vincent, Acharya, Subrat, Chowdhury, Abhijit, Duseja, Ajay, Kapoor, Dharmesh, Mukewar, Shrikant, Sarin, Shiv, Shah, Samir, Shalimar, Sood, Ajit, Tantry, BV, Ben-Ari, Ziv, Katchman, Helena, Safadi, Rifaat, Veitsman, Ella, Zuckerman, Eli, Brunetto, Maurizia, Lampertico, Pietro, Mangia, Alessandra, Akahane, Takemi, Akuta, Norio, Eguchi, Yuichiro, Fujiyama, Shigetoshi, Genda, Takuya, Hiasa, Yoichi, Ido, Akio, Ikeda, Fusao, Ikegami, Tadashi, Imajo, Kento, Itoh, Yoshito, Iwasa, Motoh, Karino, Yoshiyasu, Kato, Naoya, Kawaguchi, Takumi, Kawanaka, Miwa, Kido, Masahiro, Kobayashi, Tomoo, Kurosaki, Masayuki, Matsuzaki, Yasushi, Mita, Eiji, Mizukoshi, Eishiro, Nakahara, Takashi, Nomura, Hideyuki, Notsumata, Kazuo, Okanoue, Takeshi, Saito, Satoshi, Sakugawa, Hiroshi, Suzuki, Yoshiyuki, Takaguchi, Koichi, Takaki, Akinobu, Takashima, Tomoyuki, Tanaka, Saiyu, Tsuji, Keiji, Ueno, Yoshiyuki, Umemura, Takeji, Uto, Hirofumi, Yamashita, Nobuyuki, Yanase, Mikio, Yatsuhashi, Hiroshi, Yoneda, Masashi, Chan, Wah Kheong, Tan, Soek Siam, Garza, Laura Cisneros, Ladron De Guevara Cetina, Alma, Angeles, Rocio Guadalupe Vargas, Silva, Francisca Martinez, Van Erpecum, Karel, Orr, David, Jabłkowski, Maciej, Jaroszewicz, Jerzy, Ramos, Jose, Ahmed, Taufique, Ang, Tiing, Dan, Yock young, Goh, Boon Bee, Kaliyaperumal, Kalaiyarasi, Yip, Cherng Hann, Baik, Soon Koo, Jang, Byoung Kuk, Jun, Dae Won, Kim, Won, Kim, Hyung Joon, Kim, Ji Hoon, Lee, Kwan Sik, Lee, Chun Kyon, Lim, Young-Suk, Park, Jun Yong, Tak, Won Young, Augustin, Salvador, Perez, Salvador Benlloch, Caballeria, Juan, Luis, Jose, Panero, Calleja, Rodríguez, Jose Carrión, Garcia, Javier Crespo, Samaniego, Javier Garcia, Gibert, Pere Ginès, Prieto, Martin, Gomez, Manuel Romero, Turnes, Juan, Dufour, Jean-Francois, Moriggia, Alberto, Sheen, I-Shyan, Kao, Jia-Horng, Cheng, Pin-Nan, Huang, Jee-Fu, Yang, Sheng-Shun, Su, Wei-Wen, Chen, Chi-Yi, Chien, Rong-Nan, Lo, Gin-Ho, Chu, Chi-Jen, Wang, Horng-Yuan, Hu, Jui-Ting, Huang, Yi Wen, Agarwal, Kosh, Allison, Michael, Anstee, Quentin, Austin, Andrew, Fowell, Andrew, Ch'ng, Chin Lye, Manousou, Pinelopi, Newsome, Philip, Ryder, Stephen, Shankar, Arun, Abdelmalek, Manal, Abrams, Gary, Aguilar, Humberto, Alam, Imtiaz, Alba, Laura, Alkhouri, Naim, Allen, Alina, Aqel, Bashar, Balart, Luis, Barritt, A. Sidney, IV, Behari, Jaideep, Bennett, Michael, Bernstein, David, Bhandari, Bal Raj, Bonacini, Maurizio, Borg, Brian, Brown, Kimberly, Bzowej, Natalie, Caldwell, Stephen, Chami, Tawfik, Coates, Allan, Cueli, Adolfo, Davis, Mitchell, deLemos, Andrew, Desai, Archita, Dunn, Winston, Ferreira, Nelson, Fine, Michael, Firpi-Morell, Roberto, Freedland, Curtis, Freilich, Bradley, Fuchs, Michael, Galambos, Michael, Gallegos-Orozco, Juan, Galler, Greg, Ghali, Maged, Ghalib, Reem, Gill, Satinder, Gillis, Marcum, Gilroy, Richard, Gordon, Stuart, Gunn, Nadege, Halegoua-DeMarzio, Dina, Hassan, Mohamed, Hassanein, Tarek, Herring, Robert, Jr., Hong, John, Huang, Jonathan, Kabler, Heidi, Kayali, Zeid, Knapple, Whitfield, Kolli, Geetha, Kowdley, Kris, Krause, Richard, Lawitz, Eric, Lidofsky, Steven, Lim, Joseph, Lipkis, Donald, Loomba, Rohit, Mahgoub, Amar, Malespin, Miguel, Manch, Richard, Mannis, Steven, Manos, Paul, McDonald, Thomas, McKenzie, Mark, Mena, Edward, Merriman, Raphael, Moehlen, Martin William, Montgomery, Richard, Murphy, Robert, Natarajan, Yamini, Neff, Guy, Noureddin, Mazen, Ortiz-Lasanta, Grisell, Pagadala, Mangesh, Patel, Keyur, Patton, Heather, Peyton, Adam, Pimstone, Neville, Poulos, John, Pound, David, Pyrsopoulos, Nikolaos, Rafiq, Nila, Ravendhran, Natarajan, Ravinuthala, Ravi, Reddy, K. Rajendar, Reindollar, Robert, Reynolds, Justin, Rinella, Mary, Rizvi, Syed, Rockey, Don, Rodriguez-Perez, Federico, Ruane, Peter, Rubin, Raymond, Ryan, Michael, Saeian, Kia, Sanyal, Arun, Sarkar, Souvik, Scanga, Andrew, Schiff, Eugene, Schmidt, Warren, Schneider, Jeffrey, Sepe, Thomas, Shah, Dhiren, Shaikh, Obaid, Shankar, Uday, Sheikh, Aasim, Sheikh, Muhammad, Sherman, Kenneth, Shiffman, Mitchell, Siddique, Asma, Smith, Matthew, Suarez, Rosa, Talal, Andrew, Te, Helen, Tekola, Bezawit, Tetri, Brent, Thuluvath, Paul, Toro, Doris, Torres, Dawn, Trinh, Huy, Trotter, James, Vento, Angel, Vierling, John, Vuppalanchi, Raj, Waters, Michael, Weisberg, Ilan, Wieland, Amanda, Williams, Alonzo, Younes, Ziad, Adams, Leon, Harding, Damian, Hodge, Alex, Kontorinis, Nick, Strasser, Simone, Thompson, Alex, Horsmans, Yves, Steenkiste, Christophe Van, Bailey, Robert, Giard, Jeanne-Marie, Montano-Loza, Aldo, Puglia, Marco, Tsoi, Keith, Larrey, Dominique, Nguyen-Khac, Eric, Ratziu, Vlad, Spengler, Ulrich, Wiegand, Johannes, Hui, Aric Josun, Acharya, Subrat Kumar, Sarin, Shiv Kumar, Tantry, Vishwanath, Braun, Marius, Hazzan, Rawi, Lurie, Yoav, Colombo, Massimo, Fujii, Hideki, Hashimoto, Etsuko, Kato, Masaki, Ogawa, Koji, Takehara, Tetsuo, Tokushige, Katsutoshi, Garza, Laura Esthela Cisneros, Ladrón De Guevara, Alma Laura, Schultz, Michael, Janczewska, Ewa, Toro, Doris H., Jeong, Sook-Hyang, Kim, Yoon Jun, Lee, Jin-Woo, Ang, Tiing Leong, Bee, George Goh Boon, Benlloch, Salvador, Caballería, Juan, Calleja, José Luis, Rodríguez, Jose A. Carrión, Crespo, Javier, Diago, Moises, Fernandez-Rodriguez, Conrado, García-Samaniego, Javier, Ginès, Pere, Romero, Manuel, Dufour, Jean-François, Alazawi, William, Ch'ng, Chin-Lye, Forton, Daniel, Priest, Matthew, Sheridan, David, Ankoma-Sey, Victor, Balakrishnan, Maya, Bambha, Kiran, Barritt, A. Sidney, Bhandari, Bal, Brandman, Danielle, Chang, Charissa, Corey, Kathleen, Feldman, Michael, Gholam, Pierre, Goff, John, Marzio, Dina Halegoua-De, Harrison, Stephen, Hellstern, Paul, Jr., Herring, Robert, Iyer, Rajalakshmi, Jakiche, Antoine, Kohli, Anita, Krok, Karen, Kugelmas, Marcelo, Kumar, Sonal, Lai, Michelle, Mahmoud, Mitchell, Mantry, Parvez, Marsano, Luis, Nguyen, Tuan, Park, James, Patton, Heather M., Pockros, Paul, Reddy, Rajender, Rodriguez, Miguel, Sarles, Harry, Satapathy, Sanjaya, Sedghi, Shahriar, Shah, Nikunj, Sheikh, Muhammad Yasin, Sigal, Samuel, Stanca, Carmen, Steinbook, Michael, Szabo, Gyongyi, Terrault, Norah, Tong, Myron, Victor, David, Zervos, Xaralambos, Harrison, Stephen A., Wong, Vincent Wai-Sun, Caldwell, Stephen H., Shiffman, Mitchell L., Camargo, Marianne, Li, Georgia, Kersey, Kathryn, Jia, Catherine, Zhu, Yanni, Djedjos, C. Stephen, Subramanian, G. Mani, Myers, Robert P., Anstee, Quentin M., Romero-Gomez, Manuel, Goodman, Zachary, Lawitz, Eric J., and Younossi, Zobair

Published
2020
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9. Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in virologically suppressed patients with chronic hepatitis B: a randomised, double-blind, phase 3, multicentre non-inferiority study

Author

Lampertico, Pietro, Buti, Maria, Fung, Scott, Ahn, Sang Hoon, Chuang, Wan-Long, Tak, Won Young, Ramji, Alnoor, Chen, Chi-Yi, Tam, Edward, Bae, Ho, Ma, Xiaoli, Flaherty, John F, Gaggar, Anuj, Lau, Audrey, Liu, Yang, Wu, George, Suri, Vithika, Tan, Susanna K, Subramanian, G Mani, Trinh, Huy, Yoon, Seung-Kew, Agarwal, Kosh, Lim, Young-Suk, and Chan, Henry L Y

Published
2020
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10. An online mind-body program improves mental health and quality of life in primary biliary cholangitis: A randomized controlled trial

Author

Watt, Makayla, primary, Hyde, Ashley, additional, Johnson, Emily, additional, Wright, Gail M., additional, Vander Well, Shauna, additional, Sadasivan, Chikku, additional, Lee-Baggley, Dayna, additional, Spence, John C., additional, Mason, Andrew, additional, Ko, Hin Hin, additional, Tam, Edward, additional, and Tandon, Puneeta, additional

Published
2023
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13. Ledipasvir-Sofosbuvir Plus Ribavirin in Treatment-Naive Patients With Hepatitis C Virus Genotype 3 Infection: An Open-Label Study

Author

Feld, Jordan J., Ramji, Alnoor, Shafran, Stephen D., Willems, Bernard, Marotta, Paul, Huchet, Emmanuelle, Vachon, Marie-Louise, Svarovskaia, Evguenia S., Huang, K. C., Hyland, Robert H., Yun, Chohee, Massetto, Benedetta, Brainard, Diana M., McHutchison, John G., Tam, Edward, Bailey, Robert, Cooper, Curtis, Yoshida, Eric M., Greenbloom, Susan, Elkhashab, Magdy, Borgia, Sergio, and Swain, Mark G.

Published
2017

14. Faldaprevir, pegylated interferon, and ribavirin for treatment-naïve HCV genotype-1: pooled analysis of two phase 3 trials

Author

Jensen, Donald M., Asselah, Tarik, Dieterich, Douglas, Foster, Graham R., Sulkowski, Mark S., Zeuzem, Stefan, Mantry, Parvez, Yoshida, Eric M., Moreno, Christophe, Ouzan, Denis, Wright, Mark, Morano, Luis E., Buynak, Robert, Bourlière, Marc, Hassanein, Tarek, Nishiguchi, Shuhei, Kao, Jia-Horng, Omata, Masao, Paik, Seung W., Wong, David K., Tam, Edward, Kaita, Kelly, Feinman, S. Victor, Stern, Jerry O., Scherer, Joseph, Quinson, Anne-Marie, Voss, Florian, Gallivan, John-Paul, Böcher, Wulf O., and Ferenci, Peter

Published
2016
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16. Efficacy and safety of 12 weeks versus 18 weeks of treatment with grazoprevir (MK-5172) and elbasvir (MK-8742) with or without ribavirin for hepatitis C virus genotype 1 infection in previously untreated patients with cirrhosis and patients with previous null response with or without cirrhosis (C-WORTHY): a randomised, open-label phase 2 trial

Author

Lawitz, Eric, Gane, Edward, Pearlman, Brian, Tam, Edward, Ghesquiere, Wayne, Guyader, Dominique, Alric, Laurent, Bronowicki, Jean-Pierre, Lester, Laura, Sievert, William, Ghalib, Reem, Balart, Luis, Sund, Fredrik, Lagging, Martin, Dutko, Frank, Shaughnessy, Melissa, Hwang, Peggy, Howe, Anita Y M, Wahl, Janice, Robertson, Michael, Barr, Eliav, and Haber, Barbara

Published
2015
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17. Clinical Outcomes and Quantitative HBV Surface Antigen Levels in Diverse Chronic Hepatitis B Patients in Canada: A Retrospective Real-World Study of CHB in Canada (REVEAL-CANADA)

Author

Coffin, Carla S., primary, Haylock-Jacobs, Sarah, additional, Doucette, Karen, additional, Ramji, Alnoor, additional, Ko, Hin Hin, additional, Wong, David K., additional, Elkhashab, Magdy, additional, Bailey, Robert, additional, Uhanova, Julia, additional, Minuk, Gerald, additional, Tsoi, Keith, additional, Wong, Alexander, additional, Ma, Mang M., additional, Tam, Edward, additional, Brahmania, Mayur, additional, Nudo, Carmine, additional, Zhu, Julie, additional, Lowe, Christopher F., additional, Osiowy, Carla, additional, Lethebe, B. Cord, additional, Congly, Stephen E., additional, Chan, Eric K. H., additional, Villasis-Keever, Angelina, additional, Sbarigia, Urbano, additional, Cooper, Curtis L., additional, and Fung, Scott, additional

Published
2022
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18. Nationwide retrospective study of hepatitis B virological response and liver stiffness improvement in 465 patients on nucleos(t)ide analogue

Author

Ramji, Alnoor, primary, Doucette, Karen, additional, Cooper, Curtis, additional, Minuk, Gerald Yosel, additional, Ma, Mang, additional, Wong, Alexander, additional, Wong, David, additional, Tam, Edward, additional, Conway, Brian, additional, Truong, David, additional, Wong, Philip, additional, Barrett, Lisa, additional, Ko, Hin Hin, additional, Haylock-Jacobs, Sarah, additional, Patel, Nishi, additional, Kaplan, Gilaad G, additional, Fung, Scott, additional, and Coffin, Carla S, additional

Published
2022
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19. Clinical characterization of patients with primary biliary cholangitis: A report from multiple Canadian centres

Author

Yoshida, Eric M, primary, Swain, Mark Gordon, additional, Tsien, Cynthia, additional, Tam, Edward, additional, Bailey, Robert James, additional, Grbic, Dusanka, additional, Hin Ko, Hin, additional, Ramji, Alnoor, additional, Hilzenrat, Nir, additional, Elkhashab, Magdy, additional, Kim, Euiseok, additional, O’Brien, Meaghan, additional, Amedeo Puglia, Marco, additional, and Peltekian, Kevork M, additional

Published
2022
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23. Glecaprevir–Pibrentasvir for 8 or 12 Weeks in HCV Genotype 1 or 3 Infection

Author

Zeuzem, Stefan, Foster, Graham R., Wang, Stanley, Asatryan, Armen, Gane, Edward, Feld, Jordan J., Asselah, Tarik, Bourlière, Marc, Ruane, Peter J., Wedemeyer, Heiner, Pol, Stanislas, Flisiak, Robert, Poordad, Fred, Chuang, Wan-Long, Stedman, Catherine A., Flamm, Steven, Kwo, Paul, Dore, Gregory J., Sepulveda-Arzola, Gladys, Roberts, Stuart K., Soto-Malave, Ruth, Kaita, Kelly, Puoti, Massimo, Vierling, John, Tam, Edward, Vargas, Hugo E., Bruck, Rafi, Fuster, Francisco, Paik, Seung-Woon, Felizarta, Franco, Kort, Jens, Fu, Bo, Liu, Ran, Ng, Teresa I., Pilot-Matias, Tami, Lin, Chih-Wei, Trinh, Roger, and Mensa, Federico J.

Published
2018
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26. Patient‐specific genetic factors predict treatment failure in sofosbuvir‐treated patients with chronic hepatitis C

Author

Loucks, Catrina M., primary, Lin, Jennifer J., additional, Trueman, Jessica N., additional, Drögemöller, Britt I., additional, Wright, Galen E.B., additional, Chang, Wan‐Chun, additional, Li, Kathy H., additional, Yoshida, Eric M., additional, Ford, Jo‐Ann, additional, Lee, Samuel S., additional, Crotty, Pam, additional, Kim, Richard B., additional, Al‐Judaibi, Bandar, additional, Schwarz, Ute I., additional, Ramji, Alnoor, additional, Farivar, Jeanette F., additional, Tam, Edward, additional, Walston, Lori Lee, additional, Ross, Colin J.D., additional, and Carleton, Bruce C., additional

Published
2022
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28. Randomised clinical trial: alisporivir combined with peginterferon and ribavirin in treatment-naïve patients with chronic HCV genotype 1 infection (ESSENTIAL II)

Author

Zeuzem, S., Flisiak, R., Vierling, J. M., Mazur, W., Mazzella, G., Thongsawat, S., Abdurakhmanov, D., Van Kính, N., Calistru, P., Heo, J., Stanciu, C., Gould, M., Makara, M., Hsu, S.-J., Buggisch, P., Samuel, D., Mutimer, D., Nault, B., Merz, M., Bao, W., Griffel, L. H., Brass, C., Naoumov, N. V., Tanno, Hugo, Bessone, Fernando, Terg, Ruben, Frider, Bernardo, Bertuzzi, Romina, Desmond, Paul, Zekry, Amany, Weltman, Martin, George, Jacob, Crawford, Darrell, Matthews, Gail, Moreno, Christophe, Van Vlierberghe, Hans, Reynaert, Hendrik, Gould, Michael, Lee, Samuel, Ramji, Alnoor, Tam, Edward, Marotta, Paul, Yoshida, Eric, Wong, Florence, Feld, Jordan, Samuel, Didier, Marcellin, Patrick, Alric, Laurent, Zarski, Jean-Pierre, Zoulim, Fabien, Buggisch, Peter, Hinrichsen, Holger, Goeser, Tobias, Zeuzem, Stefan, Galle, Peter, Berg, Thomas, Schott, Eckart, Rasenack, Jens, Gerken, Guido, Wedemeyer, Hans, Tsang, Owen, Yuen, Man-Fung, Chan, Henry, Hui, Aric Josun, Makara, Mihaly, Tornai, Istvan, Gervain, Judit, Szalay, Ferenc, Varga, Marta, Horvath, Gabor, Hunyady, Bela, Vincze, Aron, Mazzella, Giuseppe, Gaeta, Giovanni Battista, Alberti, Alfredo, Colombo, Massimo, Andreone, Pietro, Rizzetto, Mario, Angelico, Mario, Craxi, Antonio, Picciotto, Antonino, Sacchi, Paolo, Vinci, Maria, Invernizzi, Pietro, Bruno, Savino, Heo, Jeong, Lee, Younjae, Cho, Mong, Han, Sangyoung, Lee, Jinwoo, Ahn, Sanghoon, Lim, Youngsuk, Hwang, Seonggyu, Sanchez, Juan, Muñoz, Linda, Maldonado, Hector, Mazur, Wlodzimierz, Flisiak, Robert, Jablkowski, Maciej, Kryczka, Wieslaw, Halota, Waldemar, Calistru, Petre, Prelipcean, Cristina, Musa, Manuela, Stanciu, Carol, Manuc, Mircea, Tanasescu, Coman, Dumitrascu, Dan, Abdurakhmanov, Djamal, Chulanov, Vladimir, Nikitin, Igor, Zhdanov, Konstantin, Esaulenko, Elena, Maevskaya, Marina, Znoyko, Olga, Lamoglia, Ricard Sola, Ferret, Maria Buti, Garcia-Samaniego, Javier, Gomez, Manuel Romero, Diago, Moises, Calleja, Jose Luis, Hsu, Shih-Jer, Chuang, Wan-Long, Hu, Tsung-Hui, Peng, Cheng-Yuan, Chen, Chi-Yi, Kao, Jia-Horng, Thongsawat, Satawat, Sukeepaisarnjaroen, Wattana, Piratvisuth, Teerha, Tanwandee, Tawesak, Komolmit, Piyawat, Agarwal, Kosh, Mutimer, David, Brown, Ashley, Foster, Graham, McPherson, Stuart, Ryder, Stephen, Poulos, John, Rustgi, Vinod, Lyche, Kip, Omarro, Steven, Vierling, John, Ghalib, Reem, Karnam, Umaprasanna, Peine, Craig, Galati, Joseph, Person, John, De La Torre, Andrew, Ravendhran, Natarajan, Mushahwar, Andria, OʼLeary, Jacqueline, Lee, William, Lawitz, Eric, Ankoma-Sey, Victor, King, John, Pound, David, Scarsella, Anthony, Thuluvath, Paul, Pockros, Paul, Mailliard, Mark, Shiffman, Mitchell, Sylvestre, Diana, Heiman, David, Jacobson, Ira, Bacon, Bruce, Dimitroff, James, Reindollar, Robert, Tobias, Hillel, Godofsky, Eliot, Rodriguez-Torres, Maribel, Bennett, Michael, Ben-Zvi, Jeffrey, Van, Kinh Nguyen, Dao, Long, Huu, Hoang Bui, Minh, Yen Lam, Le Thanh, Ly, and Van Long, Dao

Published
2015
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29. IDDF2021-ABS-0080 96-week efficacy and safety of tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) switch vs. continued TDF treatment among virologically-suppressed hepatitis B patients of asian ethnicity

Author

Ahn, Sang Hoon, primary, Kao, Jia-Horng, additional, Lampertico, Pietro, additional, Ramji, Alnoor, additional, Fung, Scott, additional, Chuang, Wan-Long, additional, Kim, Yoon Jun, additional, Chen, Chi-Yi, additional, Tam, Edward, additional, Bae, Ho, additional, Ma, Xiaoli, additional, Lee, June Sung, additional, Yee Kwan Chan, Carol, additional, Yee, Leland J, additional, Sethi, Shalini, additional, Flaherty, John, additional, Zhao, Yang, additional, Gaggar, Anuj, additional, Hann, Hie Won, additional, Lim, Young-Suk, additional, and Lik Yuen Chan, Henry, additional

Published
2021
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30. Fixed-Dose Combination Therapy With Daclatasvir, Asunaprevir, and Beclabuvir for Noncirrhotic Patients With HCV Genotype 1 Infection

Author

Poordad, Fred, Sievert, William, Mollison, Lindsay, Bennett, Michael, Tse, Edmund, Bräu, Norbert, Levin, James, Sepe, Thomas, Lee, Samuel S., Angus, Peter, Conway, Brian, Pol, Stanislas, Boyer, Nathalie, Bronowicki, Jean-Pierre, Jacobson, Ira, Muir, Andrew J., Reddy, K. Rajender, Tam, Edward, Ortiz-Lasanta, Grisell, de Lédinghen, Victor, Sulkowski, Mark, Boparai, Navdeep, McPhee, Fiona, Hughes, Eric, Swenson, E. Scott, and Yin, Philip D.

Published
2015
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31. Efficacy and safety of MK-5172 and MK-8742 ± rib-avirin in hepatitis C genotype 1 infected patients with cirrhosis or previous null response: Final results of the C-WORTHY Study (Parts A and B): 196

Author

Lawitz, Eric, Gane, Edward J., Pearlman, Brian, Tam, Edward, Ghesquiere, Wayne, Guyader, Dominique, Alric, Laurent, Bronowicki, Jean-Pierre, Rossaro, Lorenzo, Sievert, William, Ghalib, Reem H., Balart, Luis A., Sund, Fredrik, Lagging, Martin, Dutko, Frank, Howe, Anita Y., Shaughnessy, Melissa, Hwang, Peggy, Wahl, Janice, Robertson, Michael, and Haber, Barbara A.

Published
2014

32. ABT-450/r–Ombitasvir and Dasabuvir with or without Ribavirin for HCV

Author

Ferenci, Peter, Bernstein, David, Lalezari, Jacob, Cohen, Daniel, Luo, Yan, Cooper, Curtis, Tam, Edward, Marinho, Rui T., Tsai, Naoky, Nyberg, Anders, Box, Terry D., Younes, Ziad, Enayati, Pedram, Green, Sinikka, Baruch, Yaacov, Bhandari, Bal Raj, Caruntu, Florin Alexandru, Sepe, Thomas, Chulanov, Vladimir, Janczewska, Ewa, Rizzardini, Giuliano, Gervain, Judit, Planas, Ramon, Moreno, Christophe, Hassanein, Tarek, Xie, Wangang, King, Martin, Podsadecki, Thomas, and Reddy, Rajender K.

Published
2014
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33. Retreatment of HCV with ABT-450/r– Ombitasvir and Dasabuvir with Ribavirin

Author

Zeuzem, Stefan, Jacobson, Ira M., Baykal, Tolga, Marinho, Rui T., Poordad, Fred, Bourlière, Marc, Sulkowski, Mark S., Wedemeyer, Heiner, Tam, Edward, Desmond, Paul, Jensen, Donald M., Di Bisceglie, Adrian M., Varunok, Peter, Hassanein, Tarek, Xiong, Junyuan, Pilot-Matias, Tami, DaSilva-Tillmann, Barbara, Larsen, Lois, Podsadecki, Thomas, and Bernstein, Barry

Published
2014
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35. S1070 A Phase 3 Study Comparing Switching: Tenofovir Disoproxil Fumarate (TDF) to Tenofovir Alafenamide (TAF) With Continued TDF Treatment in Virologically Suppressed Patients With Chronic Hepatitis B: Final Week 96 Results

Author

Khalili, Mandana, primary, Lampertico, Pietro, additional, Bae, Ho S., additional, Ma, Xiaoli, additional, Ramji, Alnoor, additional, Fung, Scott, additional, Ahn, Sang Hoon, additional, Kao, Jia-Horng, additional, Tam, Edward, additional, Halton, Patricia, additional, Yee, Leland, additional, Flaherty, John, additional, Gaggar, Anuj, additional, Liu, Yang, additional, Wu, George, additional, Hann, Hie-Won, additional, Agarwal, Kosh, additional, Lim, Young-Suk, additional, Buti, Maria, additional, and Chan, Henry, additional

Published
2020
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36. Up to 100% SVR4 rates with ritonavir-boosted danoprevir (DNVr), mericitabine (MCB) and ribavirin (R) ± peginterferon alfa-2a (40KD) (P) in HCV genotype 1-infected partial and null responders: results from the MATTERHORN study: 81

Author

Feld, Jordan J., Jacobson, Ira M., Jensen, Donald M., Foster, Graham R., Pol, Stanislas, Tam, Edward, Berak, Hanna, Vierling, John M., Tavel, Jorge, Navarro, Mercidita T., Shahdad, Saba, Kulkarni, Rohit, Le Pogam, Sophie, Najera, Isabel, Lim, Chin Yin, and Yetzer, Ellen S.

Published
2012

37. The Z-Profile Study: a multicenter, retrospective cohort study to assess the real-world use and effectiveness of elbasvir/grazoprevir in Canadian adult patients with chronic hepatitis C

Author

Tam, Edward, primary, Tremblay, Julie, additional, Fraser, Chris, additional, Conway, Brian, additional, Ramji, Alnoor, additional, Borgia, Sergio, additional, Tsoi, Keith, additional, Yoshida, Eric M, additional, Rajendran, Bahe, additional, Macphail, Gisela, additional, Wong, Alexander, additional, Cooper, Curtis, additional, Patel, Keyur, additional, Puglia, Marco, additional, Stewart, Kris, additional, Trottier, Benoit, additional, Deshaies, Lucie, additional, Doucette, Karen, additional, Ghali, Peter, additional, Lee, Samuel S, additional, Halsey-Brandt, Jodi, additional, and Trepanier, Janie B, additional

Published
2020
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38. Efficacy of sofosbuvir/velpatasvir (s/v): impact of treatment adherence

Author

Magel, Tianna, primary, Fraser, Chris, additional, Borgia, Sergio, additional, Smyth, Daniel, additional, Cooper, Curtis, additional, Webster, Duncan, additional, Barrett, Lisa, additional, Stewart, Kristoffer, additional, Wong, Alexander, additional, Vachon, Marie-Louise, additional, Ramji, Alnoor, additional, Macphail, Gisela, additional, Hamour, Abu Obeida, additional, Bulinckx, Leeanna, additional, Tam, Edward, additional, Feld, Jordan, additional, Lee, Samuel, additional, and Conway, Brian, additional

Published
2020
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42. A phase 3 study comparing switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) with continued TDF treatment in virologically-suppressed patients with chronic hepatitis B (CHB): final week 96 efficacy and safety results

Author

Lampertico, Pietro, primary, Buti, Maria, additional, Ramji, Alnoor, additional, Fung, Scott, additional, Ahn, Sang Hoon, additional, Chuang, Wan-Long, additional, Yoon, Seung Kew, additional, Kao, Jia-Horng, additional, Chen, Chi-Yi, additional, Tam, Edward, additional, Khalili, Mandana, additional, Bae, Ho, additional, Ma, Xiaoli, additional, Tak, Won Young, additional, Flaherty, John F., additional, Gaggar, Anuj, additional, Suri, Vithika, additional, Tan, Susanna, additional, Liu, Yang, additional, Wu, George, additional, Subramanian, Mani, additional, Hann, Hie-Won, additional, Agarwal, Kosh, additional, Lim, Young-Suk, additional, and Chan, Henry, additional

Published
2020
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44. Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

Author

Younossi, Zobair M, primary, Ratziu, Vlad, additional, Loomba, Rohit, additional, Rinella, Mary, additional, Anstee, Quentin M, additional, Goodman, Zachary, additional, Bedossa, Pierre, additional, Geier, Andreas, additional, Beckebaum, Susanne, additional, Newsome, Philip N, additional, Sheridan, David, additional, Sheikh, Muhammad Y, additional, Trotter, James, additional, Knapple, Whitfield, additional, Lawitz, Eric, additional, Abdelmalek, Manal F, additional, Kowdley, Kris V, additional, Montano-Loza, Aldo J, additional, Boursier, Jerome, additional, Mathurin, Philippe, additional, Bugianesi, Elisabetta, additional, Mazzella, Giuseppe, additional, Olveira, Antonio, additional, Cortez-Pinto, Helena, additional, Graupera, Isabel, additional, Orr, David, additional, Gluud, Lise Lotte, additional, Dufour, Jean-Francois, additional, Shapiro, David, additional, Campagna, Jason, additional, Zaru, Luna, additional, MacConell, Leigh, additional, Shringarpure, Reshma, additional, Harrison, Stephen, additional, Sanyal, Arun J, additional, Abdelmalek, Manal, additional, Abrams, Gary, additional, Aguilar, Humberto, additional, Ahmed, Aijaz, additional, Aigner, Elmar, additional, Aithal, Guruprasad, additional, Ala, Aftab, additional, Alazawi, William, additional, Albillos, Agustin, additional, Allison, Michael, additional, Al-Shamma, Sfa, additional, Andrade, Raul, additional, Andreone, Pietro, additional, Angelico, Mario, additional, Ankoma-Sey, Victor, additional, Anstee, Quentin, additional, Anty, Rodolphe, additional, Araya, Victor, additional, Arenas Ruiz, Juan Ignacio, additional, Arkkila, Perttu, additional, Arora, Marty, additional, Asselah, Tarik, additional, Au, Jennifer, additional, Ayonrinde, Oyekoya, additional, Bailey, Robert James, additional, Balakrishnan, Maya, additional, Bambha, Kiran, additional, Bansal, Meena, additional, Barritt, Sidney, additional, Bate, John, additional, Beato, Jorge, additional, Behari, Jaideep, additional, Bellot, Pablo, additional, Ben Ari, Ziv, additional, Bennett, Michael, additional, Berenguer, Marina, additional, Beretta-Piccoli, Benedetta Terziroli, additional, Berg, Thomas, additional, Bonacini, Maurizio, additional, Bonet, Lucia, additional, Borg, Brian, additional, Bourliere, Marc, additional, Bowman, William, additional, Bradley, David, additional, Brankovic, Marija, additional, Braun, Marius, additional, Bronowicki, Jean-Pierre, additional, Bruno, Savino, additional, Cai, Cindy, additional, Calderon, Amy, additional, Calleja Panero, José Luis, additional, Carey, Elizabeth, additional, Carmiel, Michal, additional, Carrión, Jose Antonio, additional, Cave, Matthew, additional, Chagas, Cristina, additional, Chami, Tawfik, additional, Chang, Alan, additional, Coates, Allan, additional, Cobbold, Jeremy, additional, Costentin, Charlote, additional, Corey, Kathleen, additional, Corless, Lynsey, additional, Crespo, Javier, additional, Cruz Pereira, Oscar, additional, de Ledinghen, Victor, additional, deLemos, Andrew, additional, Diago, Moises, additional, Dong, Mamie, additional, Dufour, Jean-François, additional, Dugalic, Predrag, additional, Dunn, Winston, additional, Elkhashab, Magby, additional, Epstein, Michael, additional, Escudero-Garcia, Maria Desamparados, additional, Etzion, Ohad, additional, Evans, Larry, additional, Falcone, Robert, additional, Fernandez, Conrado, additional, Ferreira, Jose, additional, Fink, Scott, additional, Finnegan, Kevin, additional, Firpi-Morell, Roberto, additional, Floreani, Annarosa, additional, Fontanges, Thierry, additional, Ford, Ryan, additional, Forrest, Ewan, additional, Fowell, Andrew, additional, Fracanzani, Anna Ludovica, additional, Francque, Sven, additional, Freilich, Bradley, additional, Frias, Juan, additional, Fuchs, Michael, additional, Fuentes, Javier, additional, Galambos, Michael, additional, Gallegos, Juan, additional, Geerts, Anja, additional, George, Jacob, additional, Ghali, Maged, additional, Ghalib, Reem, additional, Gholam, Pierre, additional, Gines, Pere, additional, Gitlin, Norman, additional, Goeser, Tobias, additional, Goff, John, additional, Gordon, Stuart, additional, Gordon, Frederic, additional, Goria, Odile, additional, Greer, Shaun, additional, Grigorian, Alla, additional, Gronbaek, Henning, additional, Guillaume, Maeva, additional, Gunaratnam, Naresh, additional, Halegoua-De Marzio, Dina, additional, Hameed, Bilal, additional, Hametner, Stephanie, additional, Hamilton, James, additional, Hartleb, Marek, additional, Hassanein, Tarek, additional, Häussinger, Dieter, additional, Hellstern, Paul, additional, Herring, Robert, additional, Heurich, Eva, additional, Hezode, Christophe, additional, Hinrichsen, Holger, additional, Holland Fischer, Peter, additional, Horsmans, Yves, additional, Huang, Jonathan, additional, Hussaini, Hyder, additional, Jakiche, Antoine, additional, Jeffers, Lennox, additional, Jones, Blake, additional, Jorge, Rosa, additional, Jorquera, Francisco, additional, Joshi, Shoba, additional, Kahraman, Alisan, additional, Kaita, Kelly, additional, Karyotakis, Nicholas, additional, Kayali, Zeid, additional, Kechagias, Stergios, additional, Kepczyk, Thomas, additional, Khalili, Mandana, additional, Khallafi, Hicham, additional, Kluwe, Johannes, additional, Kohli, Anita, additional, Korenblat, Kevin, additional, Kowdley, Kris, additional, Krag, Aleksander, additional, Krause, Richard, additional, Kremer, Andreas, additional, Krok, Karen, additional, Krstic, Miodrag, additional, Kugelmas, Marcelo, additional, Kumar, Sonal, additional, Kuwada, Scott, additional, Labarriere, Damien, additional, Lai, Michelle, additional, Laleman, Wim, additional, Lampertico, Pietro, additional, Lee, Alice, additional, Leroy, Vincent, additional, Lidofsky, Steven, additional, Lim, Tina Huey, additional, Lim, Joseph, additional, Lipkis, Donald, additional, Little, Ester, additional, Lonardo, Amadeo, additional, Long, Michelle, additional, Luketic, Velimir Anthony Christopher, additional, Lurie, Yoav, additional, Macedo, Guilherme, additional, Magalhaes, Joana, additional, Makara, Mihály, additional, Maliakkal, Benedict, additional, Manns, Michael, additional, Manousou, Pinelopi, additional, Mantry, Parvez, additional, Marchesini, Giulio, additional, Marinho, Carla, additional, Marotta, Paul, additional, Marschall, Hanns-Ulrich, additional, Martinez, Linda, additional, Mayo, Marlyn, additional, McCullen, Mark, additional, McLaughlin, William, additional, Merle, Uta, additional, Merriman, Raphael, additional, Modi, Apurva, additional, Molina, Esther, additional, Montano-Loza, Aldo, additional, Monteverde, Carlos, additional, Morales Cardona, Amilcar, additional, Moreea, Sulleman, additional, Moreno, Christophe, additional, Morisco, Filomena, additional, Mubarak, Abdullah, additional, Muellhaupt, Beat, additional, Mukherjee, Sandeep, additional, Müller, Tobias, additional, Nagorni, Aleksandar, additional, Naik, Jahnavi, additional, Neff, Guy, additional, Nevah, Moises, additional, Newsome, Philip, additional, Nguyen-Khac, Eric, additional, Noureddin, Mazen, additional, Oben, Jude, additional, Orlent, Hans, additional, Orr, James, additional, Ortiz-Lasanta, Grisell, additional, Ozenne, Violaine, additional, Pandya, Prashant, additional, Paredes, Angelo, additional, Park, James, additional, Patel, Joykumar, additional, Patel, Keyur, additional, Paul, Sonali, additional, Patton, Heather, additional, Peck-Radosavljevic, Markus, additional, Petta, Salvatore, additional, Pianko, Stephen, additional, Piekarska, Anna, additional, Pimstone, Neville, additional, Pisegna, Joseph, additional, Pockros, Paul, additional, Pol, Stanislas, additional, Porayko, Michael, additional, Poulos, John, additional, Pound, David, additional, Pouzar, Joe, additional, Presa Ramos, Jose, additional, Pyrsopoulos, Nikolaos, additional, Rafiq, Nila, additional, Muller, Kate, additional, Ramji, Alnoor, additional, Ravinuthala, Ravi, additional, Reddy, Chakradhar, additional, Reddy K G, Gautham, additional, Reddy K R, K. Rajender, additional, Regenstein, Frederic, additional, Reindollar, Robert, additional, Reynolds, Justin, additional, Riera, Andres, additional, Rivera Acosta, Jose, additional, Robaeys, Geert, additional, Roberts, Stuart, additional, Rodriguez-Perez, Federico, additional, Romero, Sandor, additional, Romero-Gomez, Manuel, additional, Rubin, Raymond, additional, Rumi, Mariagrazia, additional, Rushbrook, Simon, additional, Rust, Christian, additional, Ryan, Michael, additional, Safadi, Rifaat, additional, Said, Adnan, additional, Salminen, Kimmo, additional, Samuel, Didier, additional, Santoro, John, additional, Sanyal, Arun, additional, Sarkar, Souvik, additional, Schaeffer, Cynthia, additional, Schattenberg, Jörn, additional, Schiefke, Ingolf, additional, Schiff, Eugene, additional, Schmidt, Wolfgang, additional, Schneider, Jeffrey, additional, Schouten, Jeoffrey, additional, Schultz, Michael, additional, Sebastiani, Giada, additional, Semela, David, additional, Sepe, Thomas, additional, Sheikh, Aasim, additional, Sheikh, Muhammad, additional, Sherman, Kenneth, additional, Shibolet, Oren, additional, Shiffman, Mitchell, additional, Siddique, Asma, additional, Sieberhagen, Cyril, additional, Sigal, Samuel, additional, Sikorska, Katarzyna, additional, Simon, Krzysztof, additional, Sinclair, Marie, additional, Skoien, Richard, additional, Solis, Joel, additional, Sood, Siddharth, additional, Souder, Bob, additional, Spivey, James, additional, Stal, Per, additional, Stinton, Laura, additional, Strasser, Simone, additional, Svorcan, Petar, additional, Szabo, Gyongzi, additional, Talal, Andrew, additional, Tam, Edward, additional, Tetri, Brent, additional, Thuluvath, Paul, additional, Tobias, Hillel, additional, Tomasiewicz, Krzysztof, additional, Torres, Dawn, additional, Tran, Albert, additional, Trauner, Michael, additional, Trautwein, Christian, additional, Tsochatzis, Emanuel, additional, Unitt, Esther, additional, Vargas, Victor, additional, Varkonyi, Istvan, additional, Veitsman, Ella, additional, Vespasiani Gentilucci, Umberto, additional, Victor, David, additional, Vierling, John, additional, Vincent, Catherine, additional, Vincze, Aron, additional, von der Ohe, Manfred, additional, Von Roenn, Natasha, additional, Vuppalanchi, Raj, additional, Waters, Michael, additional, Watt, Kymberly, additional, Wattacheril, Julia, additional, Weltman, Martin, additional, Wieland, Amanda, additional, Wiener, Gregory, additional, Williams A, Alonzo, additional, Williams J, Jeffrey, additional, Wilson, Jason, additional, Yataco, Maria, additional, Yoshida, Eric, additional, Younes, Ziad, additional, Yuan, Liyun, additional, Zivony, Adam, additional, Zogg, Donald, additional, Zoller, Heinz, additional, Zoulim, Fabien, additional, Zuckerman, Eli, additional, and Zuin, Massimo, additional

Published
2019
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46. Epidemiologic and clinical features of chronic hepatitis B virus infection in 8 Canadian provinces: a descriptive study by the Canadian HBV Network

Author

Coffin, Carla S., primary, Ramji, Alnoor, additional, Cooper, Curtis L., additional, Miles, David, additional, Doucette, Karen E., additional, Wong, Philip, additional, Tam, Edward, additional, Wong, David K., additional, Wong, Alexander, additional, Ukabam, Sylvester, additional, Bailey, Robert J., additional, Tsoi, Keith, additional, Conway, Brian, additional, Barrett, Lisa, additional, Michalak, Tomasz I., additional, Congly, Stephen E., additional, Minuk, Gerald, additional, Kaita, Kelly, additional, Kelly, Erin, additional, Ko, Hin Hin, additional, Janssen, Harry L.A., additional, Uhanova, Julia, additional, Lethebe, Brendan C., additional, Haylock-Jacobs, Sarah, additional, Ma, Mang M., additional, Osiowy, Carla, additional, and Fung, Scott K., additional

Published
2019
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47. Active management of data caches by exploiting reuse information

Author

Tam, Edward S., Rivers, Jude A., Srinivasan, Vijayalakshmi, Tyson, Gary S., and Davidson, Edward S.

Subjects
Cache memory -- Management, Data communications -- Speed, Transmission speed -- Analysis, Information storage and retrieval -- Speed
Published
1999

49. Effectiveness and Renal Safety of Tenofovir Alafenamide Fumarate among Chronic Hepatitis B Patients: Real‐World Study.

Author

Farag, Mina S., Fung, Scott, Tam, Edward, Doucette, Karen, Wong, Alexander, Ramji, Alnoor, Conway, Brian, Cooper, Curtis, Tsoi, Keith, Wong, Philip, Sebastiani, Giada, Brahmania, Mayur, Haylock‐Jacobs, Sarah, Coffin, Carla S., Hansen, Bettina E., and Janssen, Harry L.A.

Subjects
CHRONIC hepatitis B, EPIDERMAL growth factor receptors, CHRONIC kidney failure, TENOFOVIR, GLOMERULAR filtration rate, PLASMA stability
Abstract

Tenofovir alafenamide fumarate (TAF) has high plasma stability resulting in fewer renal adverse events compared to tenofovir disoproxil fumarate (TDF) in chronic hepatitis B (CHB) patients. We aimed to study the effectiveness and renal safety of TAF in a real‐world setting, in patients with or without compromised kidney function. CHB patients (Nucleos(t)ide Analogue [NA]‐naïve or experienced) who received TAF >1 year from 11 academic institutions as part of the Canadian Hepatitis B Network (CanHepB) were included. Kidney function was measured by estimated glomerular filtration rate (eGFR) as per Cockcroft‐Gault. Patients were followed for up to 160 weeks. Of 176 patients receiving TAF, 143 switched from NA (88% TDF), and 33(19%) were NA naïve. Majority of NA‐naïve patients (75%) achieved undetectable HBV DNA after one year of TAF treatment. Majority of patients with eGFR <60 mL/min who had renal deterioration during TDF (76%) reversed to eGFR increase after one year of TAF (p=0.009). Among patients with stage 2 chronic kidney disease (CKD) (eGFR 60–89), the estimated eGFR decline during TDF was halted after switching to TAF (p=0.09). NA‐experienced patients with abnormal ALT before TAF showed a significant decline after switching to TAF: −0.005 [−0.006 – −0.004] log10 ULN U/L/month, p<0.001). In CHB patients, TAF was safe, well‐tolerated and effective in this real‐world cohort. Switching to TAF led to improved kidney function, particularly in those with stage 2 CKD, which suggests that the indication for TAF in the guidelines could be extended to patients with an eGFR higher than 60 mL/min. [ABSTRACT FROM AUTHOR]

Published
2021
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