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7. Comparison of Rhinovirus A–, B–, and C–Associated Respiratory Tract Illness Severity Based on the 5′-Untranslated Region Among Children Younger Than 5 Years

Author

Sayama, Akiko, primary, Okamoto, Michiko, additional, Tamaki, Raita, additional, Saito-Obata, Mariko, additional, Saito, Mayuko, additional, Kamigaki, Taro, additional, Sayama, Yusuke, additional, Lirio, Irene, additional, Manalo, Joanna Ina G, additional, Tallo, Veronica L, additional, Lupisan, Socorro P, additional, and Oshitani, Hitoshi, additional

Published
2022
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8. Additional file 2 of Incidence of lower respiratory tract infection and associated viruses in a birth cohort in the Philippines

Author

Otani, Kanako, Saito, Mayuko, Okamoto, Michiko, Tamaki, Raita, Saito-Obata, Mariko, Kamigaki, Taro, Lirio, Irene C., Segubre-Mercado, Edelwisa, Tallo, Veronica, Lupisan, Socorro, and Oshitani, Hitoshi

Subjects
nervous system, musculoskeletal, neural, and ocular physiology, macromolecular substances, respiratory tract diseases
Abstract

Additional file 2: Figure S2. Cumulative proportion of children who developed non-severe and severe virus-specific LRTI.

Published
2022
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9. Additional file 4 of Incidence of lower respiratory tract infection and associated viruses in a birth cohort in the Philippines

Author

Otani, Kanako, Saito, Mayuko, Okamoto, Michiko, Tamaki, Raita, Saito-Obata, Mariko, Kamigaki, Taro, Lirio, Irene C., Segubre-Mercado, Edelwisa, Tallo, Veronica, Lupisan, Socorro, and Oshitani, Hitoshi

Abstract

Additional file 4: Table S2. Details of the detected viruses among cases with LRTI in which two viruses were detected in Biliran, Philippines, from March 2014 to June 2016.

Published
2022
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10. Additional file 1 of Incidence of lower respiratory tract infection and associated viruses in a birth cohort in the Philippines

Author

Otani, Kanako, Saito, Mayuko, Okamoto, Michiko, Tamaki, Raita, Saito-Obata, Mariko, Kamigaki, Taro, Lirio, Irene C., Segubre-Mercado, Edelwisa, Tallo, Veronica, Lupisan, Socorro, and Oshitani, Hitoshi

Abstract

Additional file 1: Figure S1. Number of LRTI episodes and number of children (mean) stratified by age group in the birth cohort, and number of virus positive samples observed in the original cohort study (among children aged

Published
2022
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11. Additional file 3 of Incidence of lower respiratory tract infection and associated viruses in a birth cohort in the Philippines

Author

Otani, Kanako, Saito, Mayuko, Okamoto, Michiko, Tamaki, Raita, Saito-Obata, Mariko, Kamigaki, Taro, Lirio, Irene C., Segubre-Mercado, Edelwisa, Tallo, Veronica, Lupisan, Socorro, and Oshitani, Hitoshi

Abstract

Additional file 3: Table S1. Characteristics of children in the birth cohort study by age at the end of follow-up in Biliran, Philippines, from March 2014 to June 2016.

Published
2022
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13. Enterovirus 68 among children with severe acute respiratory infection, the Philippines

Author

Imamura, Tadatsugu, Fuji, Naoko, Suzuki, Akira, Tamaki, Raita, Saito, Mariko, Aniceto, Rapunzel, Galang, Hazel, Sombrero, Lydia, Lupisan, Soccoro, and Oshitani, Hitoshi

Subjects
Nucleotide sequencing -- Methods, Enterovirus diseases -- Genetic aspects -- Care and treatment -- Demographic aspects, Respiratory tract infections -- Genetic aspects -- Care and treatment -- Demographic aspects, Health
Abstract

The genus Enterovirus (family Picornaviridae) contains 10 species: Human enterovirus (HEV) A, HEV-B, HEV-C, HEV-D, Simian enterovirus A, Bovine enterovirus, Porcine enterovirus B, Human rhinovirus (HRV) A, HRV-B, and HRV-C. [...]

Published
2011
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15. Factors affecting mothers’ intentions to visit healthcare facilities before hospitalisation of children with pneumonia in Biliran province, Philippines: a qualitative study

Author

Sato, Mari, primary, Oshitani, Hitoshi, additional, Tamaki, Raita, additional, Oyamada, Nobuko, additional, Sato, Kineko, additional, Nadra, Alkaff Raihana, additional, Landicho, Jhoys, additional, Alday, Portia P, additional, Lupisan, Socorro P, additional, and Tallo, Veronica L, additional

Published
2020
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20. Respiratory viruses from hospitalized children with severe pneumonia in the Philippines

Author

Suzuki Akira, Lupisan Socorro, Furuse Yuki, Fuji Naoko, Saito Mariko, Tamaki Raita, Galang Hazel, Sombrero Lydia, Mondoy Melisa, Aniceto Rapunzel, Olveda Remigio, and Oshitani Hitoshi

Subjects
Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Pneumonia remains a leading cause of child death in developing countries. The viruses in severe pneumonia remain poorly defined. Methods The study was conducted at the Eastern Visayas Regional Medical Center in Tacloban City, Philippines from May 2008 to May 2009. Patients aged 8 days to 13 years old who were admitted to the Department of Pediatrics with severe pneumonia were enrolled for the study. Upon admission, polymerase chain reaction was performed using nasopharyngeal swabs and blood cultures to detect respiratory viruses and bacteria, respectively. Result Among the 819 patients enrolled, at least one virus was detected in 501 cases (61.2%). In addition, 423 cases were positive for a single virus while bacteria were detected in the blood culture sample of 31 cases. The most commonly detected viruses were human rhinoviruses (n = 189), including types A (n = 103), B (n = 17), and C (n = 69), and respiratory syncytial virus (RSV) (n = 165). Novel viruses such as human metapneumovirus, human coronavirus NL63, human bocavirus, and human polyomaviruses WU and KI were also detected. There were 70 deaths, and one or more viruses were detected in 35 (50%) of these cases. Positivity only for influenza A virus (OR = 4.3, 95% CI = 1.3-14.6) was significantly associated with fatal outcome. From the blood culture, Burkholderia cepacia group (n = 9), Streptococcus pneumoniae (n = 4), Staphylococcus aureus (n = 4), Haemophilus influenzae (n = 1), and Salmonella C1 (n = 1) were also isolated. Conclusion Viruses were commonly detected in children with severe pneumonia in the Philippines. Hence, viral etiologies should be considered while developing better effective strategies to reduce child pneumonia-related deaths in developing countries.

Published
2012
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21. Aetiology and risks factors associated with the fatal outcomes of childhood pneumonia among hospitalised children in the Philippines from 2008 to 2016: a case series study

Author

Dembele, Bindongo Price Polycarpe, primary, Kamigaki, Taro, additional, Dapat, Clyde, additional, Tamaki, Raita, additional, Saito, Mariko, additional, Saito, Mayuko, additional, Okamoto, Michiko, additional, Igoy, Mary Ann U, additional, Mercado, Edelwisa Segubre, additional, Mondoy, Melisa, additional, Tallo, Veronica L, additional, Lupisan, Socorro P, additional, Egawa, Shinichi, additional, and Oshitani, Hitoshi, additional

Published
2019
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22. Transmission of Respiratory Syncytial Virus Among Children Under 5 Years in Households of Rural Communities, the Philippines

Author

Otomaru, Hirono, primary, Kamigaki, Taro, additional, Tamaki, Raita, additional, Okamoto, Michiko, additional, Alday, Portia Parian, additional, Tan, Alvin Gue, additional, Manalo, Joanna Ina, additional, Segubre-Mercado, Edelwisa, additional, Inobaya, Marianette Tawat, additional, Tallo, Veronica, additional, Lupisan, Socorro, additional, and Oshitani, Hitoshi, additional

Published
2019
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24. Father’s roles and perspectives on healthcare seeking for children with pneumonia: findings of a qualitative study in a rural community of the Philippines

Author

Sato, Mari, primary, Oshitani, Hitoshi, additional, Tamaki, Raita, additional, Oyamada, Nobuko, additional, Sato, Kineko, additional, Nadra, Alkaff Raihana, additional, Landicho, Jhoys, additional, Alday, Portia P, additional, Lupisan, Socorro, additional, and Tallo, Veronica L, additional

Published
2018
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25. Association Between Preceding Viral Respiratory Infection and Subsequent Respiratory Illnesses Among Children: A Prospective Cohort Study in the Philippines

Author

Furuse, Yuki, primary, Tamaki, Raita, additional, Okamoto, Michiko, additional, Saito-Obata, Mariko, additional, Suzuki, Akira, additional, Saito, Mayuko, additional, Imamura, Tadatsugu, additional, Khandaker, Irona, additional, Dapat, Isolde, additional, Ueno, Fumihiko, additional, Alday, Portia Parian, additional, Tan, Alvin Gue, additional, Inobaya, Marianette Tawat, additional, Segubre-Mercado, Edelwisa, additional, Tallo, Veronica, additional, Lupisan, Socorro, additional, and Oshitani, Hitoshi, additional

Published
2018
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27. Factors affecting mothers’ intentions to visit healthcare facilities before hospitalisation of children with pneumonia in Biliran province, Philippines: a qualitative study.

Author

Mari Sato, Hitoshi Oshitani, Tamaki, Raita, Nobuko Oyamada, Kineko Sato, Alkaff Raihana Nadra, Landicho, Jhoys, Alday, Portia P., Lupisan, Socorro P., and Tallo, Veronica L.

Abstract

Background and objectives Despite a substantial reduction in the mortality rate of children under 5 years in the past 25 years, pneumonia remains the single-largest infectious cause of child deaths worldwide. This study explored the chronological order of visited healthcare facilities and practitioners, and the factors affecting mothers’ intention to seek care before the hospitalisation of children with pneumonia. Methods and analysis A qualitative research design was employed using theory of planned behaviour as a framework for the analysis. Using purposive sampling technique, 11 mothers, whose children under 5 years old were hospitalised with severe pneumonia, were recruited for individual semi-structured interviews. Their sociodemographic information was analysed using descriptive statistics. Results Mothers brought their sick children to multiple facilities, and 1 to 19 days had passed before hospitalisation. We identified four major factors determining mothers’ intentions: (1) doing something useful for the sick child, (2) expecting the child to receive the necessary assessment and treatment, (3) accepting advice to visit a healthcare facility and be referred to a hospital and (4) considering issues and benefits associated with hospitalisation. Mothers noticed their children’s unusual symptoms and monitored them while applying home remedies. They also took their children to traditional healers despite knowing that the treatments were not necessarily effective. Mothers expected children to be checked by health professionals and listened to advice from family members regarding the facilities to visit, and from healthcare staff to be referred to a hospital. Financial issues and the double burden of housework and caring for the hospitalised child were mothers’ major concerns about hospitalisation. Conclusion Children were hospitalised after several days because they visited multiple healthcare facilities, including traditional healers. Improving care quality at healthcare facilities and reducing financial and mothers’ burden may reduce the hospitalisation delay for children with pneumonia. [ABSTRACT FROM AUTHOR]

Published
2020
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29. Bordetella pertussis infection in children with severe pneumonia, Philippines, 2012–2015

Author

Sadiasa, Alexander, primary, Saito-Obata, Mariko, additional, Dapat, Clyde, additional, Saito, Mayuko, additional, Frederick Quicho, Reynaldo, additional, Perez, Mauricio, additional, Joy Almonia, Daryl, additional, De Leon-Asi, Lea, additional, Tamaki, Raita, additional, Sombrero, Lydia, additional, Lupisan, Socorro, additional, and Oshitani, Hitoshi, additional

Published
2017
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30. Seasonality of Influenza and Respiratory Syncytial Viruses and the Effect of Climate Factors in Subtropical–Tropical Asia Using Influenza-Like Illness Surveillance Data, 2010 –2012

Author

Kamigaki, Taro, primary, Chaw, Liling, additional, Tan, Alvin G., additional, Tamaki, Raita, additional, Alday, Portia P., additional, Javier, Jenaline B., additional, Olveda, Remigio M., additional, Oshitani, Hitoshi, additional, and Tallo, Veronica L., additional

Published
2016
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31. Age‐specific incidence rates and risk factors for respiratory syncytial virus‐associated lower respiratory tract illness in cohort children under 5 years old in the Philippines.

Author

Ueno, Fumihiko, Tamaki, Raita, Saito, Mayuko, Okamoto, Michiko, Saito‐Obata, Mariko, Kamigaki, Taro, Suzuki, Akira, Segubre‐Mercado, Edelwisa, Aloyon, Hananiah D., Tallo, Veronica, Lupisan, Socorro P., Oshitani, Hitoshi, Landicho, Jhoys M., Reñosa, Mark Donald C., Inobaya, Marianette T., Alday, Portia P., and Tandoc, Amado O.

Subjects
*RESPIRATORY syncytial virus, *DISEASE risk factors, *AGE groups, *CHILDREN, *HEALTH facilities, *CHILD welfare
Abstract

Background: Respiratory syncytial virus (RSV) is one of the main viral causes of lower respiratory tract illness (LRTI), especially in young children. RSV vaccines, including maternal and infant vaccines, are under development; however, more epidemiological studies are needed to develop effective vaccination strategies. Objectives: To estimate detailed age‐specific incidence rates and severity of RSV‐associated LRTI (RSV‐LRTI) using data from a community‐based prospective cohort study in the Philippines. Patients/Methods: Cohort children who visited health facilities due to acute respiratory symptoms were identified, and nasopharyngeal swabs were collected to detect RSV. The severity of RSV‐LRTI was assessed using the severity definition proposed by the World Health Organization. Risk factors for developing RSV‐LRTI and contribution of SpO2 measurement were also evaluated. Results: A total of 395 RSV episodes which occurred in children aged 2‐59 months were categorised as 183 RSV‐LRTI, 72 as severe RSV‐LRTI and 29 as very severe RSV‐LRTI. Children aged 3‐5 months had the highest incidence rate of RSV‐LRTI, at 207.4 per 1000 child‐years (95% CI: 149.0‐279.5). Younger age group, place of living and low educational level of caregivers were associated with developing RSV‐LRTI. Clinical manifestations had low levels of agreement with hypoxaemia as measured by pulse oximeter. Conclusion: The highest burden of RSV was observed in young infants aged 3‐5 months, whereas the burden was also high in those aged 12‐20 months. Future vaccination strategies should consider the protection of older children, especially those aged one year, as well as young infants. [ABSTRACT FROM AUTHOR]

Published
2019
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32. Association Between Preceding Viral Respiratory Infection and Subsequent Respiratory Illnesses Among Children: A Prospective Cohort Study in the Philippines.

Author

Furuse, Yuki, Tamaki, Raita, Okamoto, Michiko, Saito-Obata, Mariko, Suzuki, Akira, Saito, Mayuko, Imamura, Tadatsugu, Khandaker, Irona, Dapat, Isolde, Ueno, Fumihiko, Alday, Portia Parian, Tan, Alvin Gue, Inobaya, Marianette Tawat, Segubre-Mercado, Edelwisa, Tallo, Veronica, Lupisan, Socorro, and Oshitani, Hitoshi

Subjects
*RESPIRATORY infections in children, *VIRUS diseases, *RESPIRATORY disease risk factors, *ETIOLOGY of diseases, *SEVERITY of illness index
Abstract

Background: Acute respiratory infection (ARI) is of great concern in public health. It remains unclear whether viral infections can affect the host's susceptibility to subsequent ARIs.Methods: A prospective cohort study on ARIs of children below 5 years old was conducted in the Philippines from 2014 to 2016. The respiratory symptoms were recorded daily, and nasopharyngeal swabs were collected at both household and health facilities. The specimens were tested for respiratory viruses. We then determined whether viral etiology was associated with the severity of the present ARI and whether previous viral infections was associated with subsequent ARIs.Results: A total of 3851 children and 16337 ARI episodes were enrolled and recorded, respectively. Samples were collected from 24% of all ARI episodes; collection rate at the healthcare facilities was 95%. Enterovirus D68, rhinovirus species C, and respiratory syncytial virus were significantly associated with severe ARIs. The risk for subsequent ARIs was significantly enhanced after infections with adenovirus, influenza A virus, parainfluenza virus type 4, and rhinovirus species C.Conclusions: This study revealed that viral etiology plays a significant role in the severity of the present ARI and that viral infection affects the host's susceptibility to subsequent ARIs. [ABSTRACT FROM AUTHOR]

Published
2019
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33. Differences in viral load among human respiratory syncytial virus genotypes in hospitalized children with severe acute respiratory infections in the Philippines

Author

Kadji, Francois Marie Ngako, primary, Okamoto, Michiko, additional, Furuse, Yuki, additional, Tamaki, Raita, additional, Suzuki, Akira, additional, Lirio, Irene, additional, Dapat, Clyde, additional, Malasao, Rungnapa, additional, Saito, Mariko, additional, Pedrera-Rico, Gay Anne Granada, additional, Tallo, Veronica, additional, Lupisan, Socorro, additional, Saito, Mayuko, additional, and Oshitani, Hitoshi, additional

Published
2016
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34. Local persistence and global dissemination play a significant role in the circulation of influenza B viruses in Leyte Island, Philippines

Author

Furuse, Yuki, primary, Odagiri, Takashi, additional, Tamaki, Raita, additional, Kamigaki, Taro, additional, Otomaru, Hirono, additional, Opinion, Jamie, additional, Santo, Arlene, additional, Dolina-Lacaba, Donna, additional, Daya, Edgard, additional, Okamoto, Michiko, additional, Saito-Obata, Mariko, additional, Inobaya, Marianette, additional, Tan, Alvin, additional, Tallo, Veronica, additional, Lupisan, Socorro, additional, Suzuki, Akira, additional, and Oshitani, Hitoshi, additional

Published
2016
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37. Molecular Characterization of Human Respiratory Syncytial Virus in the Philippines, 2012-2013

Author

Malasao, Rungnapa, primary, Okamoto, Michiko, additional, Chaimongkol, Natthawan, additional, Imamura, Tadatsugu, additional, Tohma, Kentaro, additional, Dapat, Isolde, additional, Dapat, Clyde, additional, Suzuki, Akira, additional, Saito, Mayuko, additional, Saito, Mariko, additional, Tamaki, Raita, additional, Pedrera-Rico, Gay Anne Granada, additional, Aniceto, Rapunzel, additional, Quicho, Reynaldo Frederick Negosa, additional, Segubre-Mercado, Edelwisa, additional, Lupisan, Socorro, additional, and Oshitani, Hitoshi, additional

Published
2015
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39. Incidence and Risk Factors of Childhood Pneumonia-Like Episodes in Biliran Island, Philippines—A Community-Based Study

Author

Kosai, Hisato, primary, Tamaki, Raita, additional, Saito, Mayuko, additional, Tohma, Kentaro, additional, Alday, Portia Parian, additional, Tan, Alvin Gue, additional, Inobaya, Marianette Tawat, additional, Suzuki, Akira, additional, Kamigaki, Taro, additional, Lupisan, Soccoro, additional, Tallo, Veronica, additional, and Oshitani, Hitoshi, additional

Published
2015
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40. Influenza and Other Respiratory Viruses Detected by Influenza-Like Illness Surveillance in Leyte Island, the Philippines, 2010–2013

Author

Otomaru, Hirono, primary, Kamigaki, Taro, additional, Tamaki, Raita, additional, Opinion, Jamie, additional, Santo, Arlene, additional, Daya, Edgard, additional, Okamoto, Michiko, additional, Saito, Mariko, additional, Tallo, Veronica, additional, Lupisan, Soccoro, additional, Suzuki, Akira, additional, and Oshitani, Hitoshi, additional

Published
2015
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42. Antigenic and Receptor Binding Properties of Enterovirus 68

Author

Imamura, Tadatsugu, primary, Okamoto, Michiko, additional, Nakakita, Shin-ichi, additional, Suzuki, Akira, additional, Saito, Mariko, additional, Tamaki, Raita, additional, Lupisan, Socorro, additional, Roy, Chandra Nath, additional, Hiramatsu, Hiroaki, additional, Sugawara, Kan-etsu, additional, Mizuta, Katsumi, additional, Matsuzaki, Yoko, additional, Suzuki, Yasuo, additional, and Oshitani, Hitoshi, additional

Published
2014
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44. Molecular Evolution of Enterovirus 68 Detected in the Philippines

Author

Imamura, Tadatsugu, primary, Suzuki, Akira, additional, Lupisan, Socorro, additional, Okamoto, Michiko, additional, Aniceto, Rapunzel, additional, Egos, Rutchie J., additional, Daya, Edgardo E., additional, Tamaki, Raita, additional, Saito, Mariko, additional, Fuji, Naoko, additional, Roy, Chandra Nath, additional, Opinion, Jaime M., additional, Santo, Arlene V., additional, Macalalad, Noel G., additional, Tandoc, Amado, additional, Sombrero, Lydia, additional, Olveda, Remigio, additional, and Oshitani, Hitoshi, additional

Published
2013
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45. Genetic characterization of human respiratory syncytial virus detected in hospitalized children in the Philippines from 2008 to 2012

Author

Ohno, Ayumu, primary, Suzuki, Akira, additional, Lupisan, Socorro, additional, Galang, Hazel, additional, Sombrero, Lydia, additional, Aniceto, Rapunzel, additional, Okamoto, Michiko, additional, Saito, Mariko, additional, Fuji, Naoko, additional, Otomaru, Hirono, additional, Roy, Chandra Nath, additional, Yamamoto, Dai, additional, Tamaki, Raita, additional, Olveda, Remigio, additional, and Oshitani, Hitoshi, additional

Published
2013
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