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Entomopathogenic nematodes (EPNs) have been identified as promising biocontrol agents for controlling economically important insect pests of agricultural and horticultural crops. The compatibility of entomopathogenic nematode Heterorhabditis indica with 7 CIB registered insecticides was investigated under laboratory conditions. The effect of these insecticides on nematode survival at recommended concentrations was observed after 12, 24, 48, 72 hours upon direct exposure. EPN H. indica was compatible with Imidacloprid 17.8% SL as maximum per cent of live H. indica were observed after 72 h of exposure to this insecticide. Similarly, H. indica was compatible with Fipronil 5% SC up to 48 h of exposure whereas, less than 70% live EPN were there in Thiamethoxam 25% WG, Diafenthiuron 50% WP and Cypermethrin 25% EC resulting these insecticides to be least compatible. Emamectin benzoate 5% SG and chlorpyriphos 20% EC were incompatible with H. indica after 48 h of exposure. The result of this experiment will help in reducing the dependence on chemical insecticides and thus slowing down the development of insecticide resistance and preventing adverse effects on public health and the environment.