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1. Differential diagnosis: retroperitoneal fibrosis and oncological diseases

Author

Sica Antonello, Casale Beniamino, Spada Alessandro, Teresa Di Dato Maria, Sagnelli Caterina, Calogero Armando, Buonavolontà Pietro, Salzano Anna, Martinelli Erika, Saracco Elisabetta, Troiani Teresa, Anna Dodaro Concetta, Tammaro Dario, Luisa De Rimini Maria, Ciardiello Fortunato, and Papa Alfonso

Subjects
retroperitoneal fibrosis, oncological disease, lymphomas, Medicine
Abstract

Retroperitoneal fibrosis is a connective disease of the auto-inflammatory/auto-immune type of the retroperitoneum with unknown etiology and pathological mechanism. The manifestations of the pathology can be local or systemic. Amongst the local symptoms, the dull and constant pain in the hips, back or abdomen is the most frequent.

Published
2019
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2. Cancer- and non-cancer related chronic pain: from the physiopathological basics to management

Author

Sica Antonello, Casale Beniamino, Dato Maria Teresa Di, Calogero Armando, Spada Alessandro, Sagnelli Caterina, Santagata Mario, Buonavolontà Pietro, Fiorelli Alfonso, Salzano Anna, Dodaro Concetta Anna, Martinelli Erika, Saracco Elisabetta, Troiani Teresa, Tammaro Dario, Ciardiello Fortunato, and Papa Alfonso

Subjects
pain, chronic pain, non-cancer pain, cancer pain, intrathecal therapy, chronic pain therapy, Medicine
Abstract

The prevalence of chronic pain is between 33% to 64% and is due to cancer pain, but it has also been observed in non-cancer patients. Chronic pain is associated with lower quality of life and higher psychological distress and depressive/anxiety disorders in patients without a history of disorder.

Published
2019
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3. Long-term efficacy and reduced side-effects of buprenorphine in patients with moderate and severe chronic pain.

Author

Papa, Alfonso, Maria Salzano, Anna, Di Dato, Maria Teresa, Desiderio, Vincenzo, Buonavolontà, Pietro, Mango, Pietro, Saracco, Elisabetta, Tammaro, Dario, Luongo, Livio, and Maione, Sabatino

Subjects
TRANSDERMAL medication, PATIENT satisfaction, PAIN tolerance, CHRONIC pain, OPIOID epidemic, BUPRENORPHINE, OPIOIDS
Abstract

Background: Chronic pain significantly impacts quality of life and poses substantial public health challenges. Buprenorphine, a synthetic analog of thebaine, is recognized for its potential in managing moderate to severe chronic pain with fewer side effects and a lower incidence of tolerance compared to traditional opioids. Objective: This retrospective study aimed to assess the long-term efficacy and safety of buprenorphine transdermal patches in patients with moderate and severe chronic pain, with a focus on pain relief sustainability and tolerance development. Methods: This retrospective observational study involved 246 patients prescribed buprenorphine transdermal patches. We evaluated changes in pain intensity using the Numeric Rating Scale (NRS), assessed opioid tolerance based on FDA guidelines for morphine-equivalent doses, and measured patientreported outcomes through the Patients' Global Impression of Change (PGIC). Any adverse events were also recorded. Results: Over the 36-month period, there was a significant reduction in NRS scores for both moderate and severe pain patients, demonstrating buprenorphine's sustained analgesic effect. Tolerance measurement indicated that no patients required increases in morphine-equivalent doses that would meet or exceed the FDA's threshold for opioid tolerance (60 mg/day of morphine or equivalent). Additionally, patient satisfaction was high, with the PGIC reflecting significant improvements in pain management and overall wellbeing. The side effects were minimal, with skin reactions and nausea being the most commonly reported but manageable adverse events. Conclusion: The study findings validate the long-term use of buprenorphine transdermal patches as an effective and safe option for chronic pain management, maintaining efficacy without significant tolerance development. These results support the continued and expanded use of buprenorphine in clinical settings, emphasizing its role in reducing the burdens of chronic pain and opioid-related side effects. Further research is encouraged to refine pain management protocols and explore buprenorphine's full potential in diverse patient populations. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Corrigendum: Long-term efficacy and reduced side-effects of buprenorphine in patients with moderate and severe chronic pain.

Author

Papa, Alfonso, Salzano, Anna Maria, Di Dato, Maria Teresa, Desiderio, Vincenzo, Buonavolontà, Pietro, Mango, Pietro, Saracco, Elisabetta, Tammaro, Dario, Luongo, Livio, and Maione, Sabatino

Subjects
PATIENTS' attitudes, OPIOID epidemic, PATIENT satisfaction, PAIN tolerance, ANALGESIA, BUPRENORPHINE
Abstract

The correction notice in the journal "Frontiers in Pharmacology" addresses errors in Figures 1, 4, and 5 of an article on the long-term efficacy and reduced side-effects of buprenorphine in patients with chronic pain. The corrected figures now accurately represent additional therapies prescribed alongside buprenorphine, patient-reported outcomes assessed by the PGIC scale, and trends in morphine-equivalent doses for patients with moderate pain. The authors acknowledge the mistake but clarify that it does not impact the scientific conclusions of the original article. [Extracted from the article]

Published
2024
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6. Breakthrough Cancer Pain: Preliminary Data of The Italian Oncologic Pain Multisetting Multicentric Survey (IOPS-MS)

Author

Mercadante, Sebastiano, Marchetti, Paolo, Cuomo, Arturo, Caraceni, Augusto, Mediati, Rocco Domenico, Mammucari, Massimo, Natoli, Silvia, Lazzari, Marzia, Dauri, Mario, Airoldi, Mario, Azzarello, Giuseppe, Bandera, Mauro, Blasi, Livio, Cartenì, Giacomo, Chiurazzi, Bruno, Costanzo, Benedetta Veruska Pierpaola, Degiovanni, Daniela, Fusco, Flavio, Guardamagna, Vittorio, Iaffaioli, Vincenzo, Liguori, Simeone, Lorusso, Vito, Mameli, Sergio, Mattioli, Rodolfo, Mazzei, Teresita, Melotti, Rita Maria, Menardo, Valentino, Miotti, Danilo, Moroso, Stefano, De Santis, Stefano, Orsetti, Remo, Papa, Alfonso, Ricci, Sergio, Sabato, Alessandro Fabrizio, Scelzi, Elvira, Sofia, Michele, Tonini, Giuseppe, Aielli, Federica, Valle, Alessandro, Caruselli, Amanda, Prestia, Giovanna, Giusti, Raffaele, Costanzi, Andrea, Angelini, Silvia, Iacono, Daniela, Mazzuca, Federica, Carnevale, Alessia, Bonome, Paolo, Nicosia, Luca, Scaringi, Claudia, Montalto, Adelaide, Russo, Gennaro, Forte, Cira Antonietta, Esposito, Gennaro, Bracchi, Paola, Zecca, Ernesto, Campa, Tiziana, Grecchi, Silvia, Pigni, Alessandra, Sammaro, Annunziata, Dodaro, Lucia, Ballerini, Giovanna, Vellucci, Renato, Caldarulo, Clarissa, Palombo, Elisa, Diviza, Marco, Gianfelice, Valentina, Silvestri, Claudia, Finocchi, Simona, Contu, Viviana, Fora, Gianluca, Pedani, Fulvia, Icardi, Massimiliano, Bellini, Elisa, Celano, Alfredo, Berardo, Roberto, Ostellino, Oliviero, Sartori, Kayta, Demartini, Paola, Scroccaro, Raffaella, Boscolo, Giorgia, Sartori, Donata, Rosetti, Francesco, Artioli, Grazia, Borgato, Lucia, Bertoldero, Giovanni, Veronese, Barbara, Vallini, Ilaria, Tuzi, Alessandro, Bolzacchini, Elena, Pinotti, Graziella, Alù, Massimiliano, Usset, Antonella, Arcuri, Carmela, Laudani, Agata, Pepe, Alessio, Scagliarini, Sarah, Sgarlata, Massimiliano Savio Maria, Raimondi, Massimo, Valenti, Salvatore Maria Giovanni, Bucceri, Alberto, Kasa, Alma, Budel, Paola, Caramellino, Anna, Ballarino, Paola, Donelli, Emanuela, Silvestro, Stefania, Tonetti, Rossella, Bozzoni, Samuela, Cocquio, Angela, Romano, Carmela, Nappi, Anna, Silvestro, Lucrezia, De Divitiis, Chiara, Ghidoni, Silvia, Cortinovis, Rosalba, Marchesi, Roberta, Fortis, Michele, Palermo, Loredana, Pisanu, Giovanni Maria, Carboni, Maura, Meloni, Francesca, Barillari, Daniele, Imperatori, Luca, Grilli, Gianni, Laici, Gianluca, Diacciati, Sara, Petreni, Paolo, Samolsky Dekel, Boaz, Marsigli, Federica, Manfreda, Miriam, Ghedini, Silvia, Bruno, Emanuela, Salvini, Emanuele, Gerboni, Davide, Saulle, Serena, Carella, Roberta, Pascoletti, Gaetano, Bolzonello, Silvia, Bonotto, Marta, Ellero, Silvia, Fasola, Gianpiero, Ongaro, Elena, Borghesi, Cristina, Germani, Lucia, De Ruvo, Edoardo, Marchetti, Federica, Pasquale, Milena, Masu, Lucia, Tammaro, Dario, Saracco, Elisabetta, Di Dato, Maria Teresa, Ferrara, Maurizio, Pironti, Andrea, Buonavolontà, Pietro, Ginocchi, Laura, Musettini, Gianna, Antonuzzo, Andrea, Caparello, Chiara, Lucchesi, Maurizio, Farnesi, Azzurra, Zampieri, Mari, Pisciotta, Manuela, Fioroni, Iacopo, Ratta, Raffaele, Cursano, Maria Concetta, Santini, Daniele, Potestà, Cinzia, Gallo, Gloria, Saber, Benhaz, and On behalf of the IOPS MS study group

Published
2017
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7. Erratum to: Breakthrough pain and its treatment: critical review and recommendations of IOPS (Italian Oncologic Pain Survey) expert group

Author

Mercadante, Sebastiano, Marchetti, Paolo, Cuomo, Arturo, Mammucari, Massimo, Caraceni, Augusto, Mediati, Rocco Domenico, Caruselli, Amanda, Costanzi, Andrea, Bracchi, Paola, Dodaro, Lucia, Contu, Viviana, Fora, Gianluca, Veronese, Barbara, Alu, Massimiliano, Chiurazzi, Bruno, Sgarlata, Massimiliano, Kasa, Alma, Donelli, Emanuela, Silvestro, Stefania, Romano, Carmela, Ghidoni, Silvia, Palermo, Loredana, Pisanu, Giovanni Maria, Imperatori, Luca, Diacciati, Sara, Samolsky Dekel, Boaz Gedaliahu, Bruno, Emanuela, Saulle, Serena, Bonotto, Marta, De santis, Stefano, Tammaro, Dario, Ginocchi, Laura, Zampieri, Mari, Fioroni, Iacopo, Gallo, Gloria, Saber, Benhaz, Dauri, Mario, Airoldi, Mario, Azzarello, Giuseppe, Bandera, Mauro, Blasi, Livio, Carteni, Giacomo, Costanzo, Veruska, Degiovanni, Daniela, Fusco, Flavio, Guardamagna, Vittorio, Iaffaioli, Vincenzo, Lazzari, Marzia, Liguori, Simeone, Lorusso, Vito, Mameli, Sergio, Mattioli, Rodolfo, Mazzei, Teresita, Melotti, Rita Maria, Menardo, Valentino, Miotti, Danilo, Moroso, Stefano, Natoli, Silvia, Orsetti, Remo, Papa, Alfonso, Ricci, Sergio, Sabato, Alessandro Fabrizio, Scelzi, Elvira, Sofia, Michele, Tonini, Giuseppe, Valle, Alessandro, and on behalf of the IOPS MS study Group

Published
2017
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11. Intraarticular STP Radiofrequency for Painful Osteoarthritis in the Knee: A Retrospective Single Center Analysis

Author

Papa,Alfonso, Di Dato,Maria Teresa, Lo Bianco,Giuliano, Gazzerro,Giuseppe, Salzano,Anna Maria, Di Costanzo,Emilio, Tammaro,Dario, Schatman,Michael E, Varrassi,Giustino, Papa,Alfonso, Di Dato,Maria Teresa, Lo Bianco,Giuliano, Gazzerro,Giuseppe, Salzano,Anna Maria, Di Costanzo,Emilio, Tammaro,Dario, Schatman,Michael E, and Varrassi,Giustino

Abstract

Alfonso Papa,1 Maria Teresa Di Dato,1 Giuliano Lo Bianco,1– 3 Giuseppe Gazzerro,1 Anna Maria Salzano,1 Emilio Di Costanzo,1 Dario Tammaro,1 Michael E Schatman,4,5 Giustino Varrassi6 1Pain Department AO “Ospedali dei Colli”, Monaldi Hospital, Naples, Italy; 2Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, Catania, Italy; 3Anesthesiology and Pain Department, Fondazione Istituto G. Giglio, Cefalù, Italy; 4Department of Anesthesiology, Perioperative Care, and Pain Medicine, NYU School of Medicine, New York, NY, USA; 5School of Social Work, North Carolina State University, Raleigh, NC, USA; 6Paolo Procacci Foundation, Rome, ItalyCorrespondence: Giuliano Lo Bianco Tel +393289682219Email giulianolobianco@gmail.comObjective: Osteoarthritis (OA) is the most common cause of chronic knee pain, often a debilitating condition that can cause a significant reduction in functional capacity. Radiofrequency is a form of neuromodulation that modulates pain signal transmission and has become progressively more common as a treatment for knee pain. This retrospective study aims to evaluate the efficacy of intraarticular radiofrequency in patients with chronic knee OA pain.Materials and Methods: In this retrospective study, we included 129 patients undergoing intraarticular pulsed radiofrequency using the Poisson curve for energy distribution (Sluijter-Teixeira Poisson radiofrequency) (STP) from March 2018 to November 2019. Knee osteoarthritis severity was assessed prior to the procedure using the Lequesne Index, classifying patients into six groups based on level of severity. Pain intensity was assessed through a 10-cm visual analog scale (VAS), and level of patient satisfaction was assessed through a questionnaire.Results: In the sample, pain reduction as measured by VAS compared to baseline prior to the procedure was statistically significant immediately following the procedure, at 30 days and at 90 days (p< 0.001); this difference wa

Published
2021

12. Chronic Chest Pain Control after Trans-Thoracic Biopsy in Mediastinal Lymphomas

Author

Sica, Antonello, primary, Casale, Beniamino, additional, Sagnelli, Caterina, additional, Di Dato, Maria Teresa, additional, Rispoli, Marco, additional, Santagata, Mario, additional, Buonavolontà, Pietro, additional, Fiorelli, Alfonso, additional, Vitiello, Paola, additional, Caccavale, Stefano, additional, Creta, Massimiliano, additional, Salzano, Anna Maria, additional, Sagnelli, Evangelista, additional, Saracco, Elisabetta, additional, Gazzerro, Giuseppe, additional, Famiglietti, Vincenzo, additional, Tammaro, Dario, additional, and Papa, Alfonso, additional

Published
2021
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14. All-in-One Spinal Cord Stimulation in Lymphoproliferative Diseases

Author

Sica, Antonello, primary, Casale, Beniamino, additional, Sagnelli, Caterina, additional, Di Dato, Maria Teresa, additional, Buonavolontà, Pietro, additional, Salzano, Anna Maria, additional, Sagnelli, Evangelista, additional, Famiglietti, Vincenzo, additional, Saracco, Elisabetta, additional, Tammaro, Dario, additional, and Papa, Alfonso, additional

Published
2020
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18. Post-Operative Chronic Pain Control in Mediastinal Lymphomas in An Elderly Population: the Role of Physical Activity

Author

Sica, Antonello, primary, Casale, Beniamino, additional, Sagnelli, Caterina, additional, Calogero, Armando, additional, Di Dato, Maria Teresa, additional, Spada, Alessandro, additional, Rispoli, Marco, additional, Santagata, Mario, additional, Buonavolontà, Pietro, additional, Fiorelli, Alfonso, additional, Tammaro, Vincenzo, additional, Ciccozzi, Massimo, additional, Salzano, Anna, additional, Sagnelli, Evangelista, additional, Saracco, Elisabetta, additional, Tammaro, Dario, additional, and Papa, Alfonso, additional

Published
2019
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19. Differential diagnosis: retroperitoneal fibrosis and oncological diseases.

Author

Sica, Antonello, Casale, Beniamino, Spada, Alessandro, Teresa Di Dato, Maria, Sagnelli, Caterina, Calogero, Armando, Buonavolontà, Pietro, Salzano, Anna, Martinelli, Erika, Saracco, Elisabetta, Troiani, Teresa, Anna Dodaro, Concetta, Tammaro, Dario, Luisa De Rimini, Maria, Ciardiello, Fortunato, and Papa, Alfonso

Subjects
DIFFERENTIAL diagnosis, RETROPERITONEAL fibrosis, OVARIAN cancer, DISEASES, ETIOLOGY of diseases, RETROPERITONEUM
Abstract

Retroperitoneal fibrosis is a connective disease of the auto-inflammatory/auto-immune type of the retroperitoneum with unknown etiology and pathological mechanism. The manifestations of the pathology can be local or systemic. Amongst the local symptoms, the dull and constant pain in the hips, back or abdomen is the most frequent. We report here a case of a 47-year-old woman, whose pathogenic mechanism could be related to an "IgG4-related disease" disorder as suggested by an increased serum level of this subclass of IgG and the positive immunohistochemistry. The diagnosis is not easy, because this pathology generates masses; adenomegalies with retro peritoneal development, that makes it similar to lymphomas or metastases from ovarian tumors. [ABSTRACT FROM AUTHOR]

Published
2020
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20. Cancer- and Non-cancer Related Chronic Pain: From the Physiopathological Basics to Management

Author

Alessandro Spada, Elisabetta Saracco, Teresa Troiani, Mario Santagata, Maria Teresa Di Dato, Anna Maria Salzano, Fortunato Ciardiello, Antonello Sica, Dario Tammaro, Caterina Sagnelli, Pietro Buonavolontà, Armando Calogero, Erika Martinelli, Concetta Anna Dodaro, Alfonso Fiorelli, Beniamino Casale, Alfonso Papa, Sica, Antonello, Casale, Beniamino, Dato, Maria Teresa Di, Calogero, Armando, Spada, Alessandro, Sagnelli, Caterina, Santagata, Mario, Buonavolontà, Pietro, Fiorelli, Alfonso, Salzano, Anna, Dodaro, Concetta Anna, Martinelli, Erika, Saracco, Elisabetta, Troiani, Teresa, Tammaro, Dario, Ciardiello, Fortunato, Papa, Alfonso, Sica, A., Casale, B., Dato, M. T. D., Calogero, A., Spada, A., Sagnelli, C., Santagata, M., Buonavolonta, P., Fiorelli, A., Salzano, A., Dodaro, C. A., Martinelli, E., Saracco, E., Troiani, T., Tammaro, D. F., Ciardiello, F., and Papa, A.

Subjects
medicine.medical_specialty, Dose, Intrathecal therapy, Pain, Chronic pain, 03 medical and health sciences, 0302 clinical medicine, Refractory, Quality of life, Internal medicine, chronic pain therapy, Medicine, Intrathecal pump, 030212 general & internal medicine, Cancer pain, business.industry, Cancer, General Medicine, medicine.disease, Anxiety, medicine.symptom, business, 030217 neurology & neurosurgery, Research Article, Non-cancer pain
Abstract

The prevalence of chronic pain is between 33% to 64% and is due to cancer pain, but it has also been observed in non-cancer patients. Chronic pain is associated with lower quality of life and higher psychological distress and depressive/anxiety disorders in patients without a history of disorder. In this study we evaluated in clinical practice the effectiveness of the intrathecal pump in 140 patients who underwent pain therapy at our Center. These patients were consecutively enrolled from January 2010 to July 2018. Follow-up was carried out over these eight years regarding the infusion modalities. Pain relief was obtained in 71 (50,7%) patients out of the 140 that experienced satisfactory pain control globally. Intrathecal therapy is one of the best options for chronic severe refractory pain. The greatest advantage of this therapy is due to the possibility of treating the pain with minimal dosages of the drug, avoiding the appearance of troublesome side effects.

Published
2019

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