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11 results on '"Tammekivi, Veronika"'

4. Variation in FGF1, FOXE1, and TIMP2genes is associated with nonsyndromic cleft lip with or without cleft palate

Author

Nikopensius, Tiit, primary, Kempa, Inga, additional, Ambrozaitytė, Laima, additional, Jagomägi, Triin, additional, Saag, Mare, additional, Matulevičienė, Aušra, additional, Utkus, Algirdas, additional, Krjutškov, Kaarel, additional, Tammekivi, Veronika, additional, Piekuse, Linda, additional, Akota, Ilze, additional, Barkane, Biruta, additional, Krumina, Astrida, additional, Klovins, Janis, additional, Lace, Baiba, additional, Kučinskas, Vaidutis, additional, and Metspalu, Andres, additional

Published
2011
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5. Genetic variants in COL2A1, COL11A2, and IRF6 contribute risk to nonsyndromic cleft palate

Author

Nikopensius, Tiit, primary, Jagomägi, Triin, additional, Krjutškov, Kaarel, additional, Tammekivi, Veronika, additional, Saag, Mare, additional, Prane, Inga, additional, Piekuse, Linda, additional, Akota, Ilze, additional, Barkane, Biruta, additional, Krumina, Astrida, additional, Ambrozaitytė, Laima, additional, Matulevičienė, Aušra, additional, Kučinskienė, Zita Aušrelė, additional, Lace, Baiba, additional, Kučinskas, Vaidutis, additional, and Metspalu, Andres, additional

Published
2010
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6. Polymorphisms in wolframin (WFS1) gene are possibly related to increased risk for mood disorders

Author

Koido, Kati, primary, Kõks, Sulev, additional, Nikopensius, Tiit, additional, Maron, Eduard, additional, Altmäe, Signe, additional, Heinaste, Evelin, additional, Vabrit, Kristel, additional, Tammekivi, Veronika, additional, Hallast, Pille, additional, Kurg, Ants, additional, Shlik, Jakov, additional, Vasar, Veiko, additional, Metspalu, Andres, additional, and Vasar, Eero, additional

Published
2005
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7. Analysis of SNP profiles in patients with major depressive disorder

Author

Kõks, Sulev, primary, Nikopensius, Tiit, additional, Koido, Kati, additional, Maron, Eduard, additional, Altmäe, Signe, additional, Heinaste, Evelin, additional, Vabrit, Kristel, additional, Tammekivi, Veronika, additional, Hallast, Pille, additional, Kurg, Ants, additional, Shlik, Jakov, additional, Vasar, Veiko, additional, Metspalu, Andres, additional, and Vasar, Eero, additional

Published
2005
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8. Association study of 90 candidate gene polymorphisms in panic disorder

Author

Maron, Eduard, primary, Nikopensius, Tiit, additional, K??ks, Sulev, additional, Altm??e, Signe, additional, Heinaste, Evelin, additional, Vabrit, Kristel, additional, Tammekivi, Veronika, additional, Hallast, Pille, additional, Koido, Kati, additional, Kurg, Ants, additional, Metspalu, Andres, additional, Vasar, Eero, additional, Vasar, Veiko, additional, and Shlik, Jakov, additional

Published
2005
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10. Analysis of SNP profiles in patients with major depressive disorder

Author

Kõks, Sulev, Nikopensius, Tiit, Koido, Kati, Maron, Eduard, Altmäe, Signe, Heinaste, Evelin, Vabrit, Kristel, Tammekivi, Veronika, Hallast, Pille, Kurg, Ants, Shlik, Jakov, Vasar, Veiko, Metspalu, Andres, and Vasar, Eero

Abstract

The present study focused on 91 single-nucleotide polymorphisms (SNPs) in 21 candidate genes to find associations with major depressive disorder (MDD). In total, 160 healthy controls and 177 patients with MDD were studied. We applied arrayed primer extension (APEX) based genotyping technology followed by association and haplotype analysis. SNPs in CCKAR, DRD1, DRD2, and HTR2C genes showed nominally significant associations with MDD. None of these associations remained significant after adjustment for multiple testing. Haplotype analysis revealed CCKAR haplotypes to be associated with MDD (global p=0.004). More precisely, we found the GAGT haplotype to be associated with increased risk for MDD (OR 7.42, 95% CI 2.13–25.85, p=0.002). This haplotype effect remained significant after Bonferroni correction (p=0.04 after Bonferroni's adjustment). Altogether we were able to find some nominal associations, but due to small sample size these results should be taken as exploratory. However, the effect of GAGT haplotype on the CCKAR gene may be considered as increasing the risk for MDD.

Published
2006
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11. Variation in FGF1, FOXE1, and TIMP2 genes is associated with nonsyndromic cleft lip with or without cleft palate.

Author

Nikopensius T, Kempa I, Ambrozaitytė L, Jagomägi T, Saag M, Matulevičienė A, Utkus A, Krjutškov K, Tammekivi V, Piekuse L, Akota I, Barkane B, Krumina A, Klovins J, Lace B, Kučinskas V, and Metspalu A

Subjects
Case-Control Studies, Cell Adhesion Molecules genetics, Cleft Lip epidemiology, Cleft Palate epidemiology, Epistasis, Genetic, Estonia epidemiology, Female, Genetic Loci, Haplotypes, Homeodomain Proteins genetics, Humans, LIM-Homeodomain Proteins, Latvia epidemiology, Lithuania epidemiology, Male, Nectins, Signal Transduction, Transcription Factors, Wnt Proteins genetics, Cleft Lip genetics, Cleft Palate genetics, Fibroblast Growth Factor 1 genetics, Forkhead Transcription Factors genetics, Polymorphism, Single Nucleotide, Tissue Inhibitor of Metalloproteinase-2 genetics
Abstract

Background: Nonsyndromic cleft lip with or without cleft palate (CL/P) is a common complex birth defect caused by the interaction between multiple genes and environmental factors., Methods: Five hundred and eighty-seven single nucleotide polymorphisms in 40 candidate genes related to orofacial clefting were tested for association with CL/P in a clefting sample composed of 300 patients and 606 controls from Estonian, Latvian, and Lithuanian populations., Results: In case-control comparisons, the minor alleles of FGF1 rs34010 (p = 4.56 × 10(-4) ), WNT9B rs4968282 (p = 0.0013), and FOXE1 rs7860144 (p = 0.0021) were associated with a decreased risk of CL/P. Multiple haplotypes in FGF1, FOXE1, and TIMP2 and haplotypes in WNT9B, PVRL2, and LHX8 were associated with CL/P. The strongest association was found for protective haplotype rs250092/rs34010 GT in the FGF1 gene (p = 5.01 × 10(-4) ). The strongest epistatic interaction was observed between the COL2A1 and WNT3 genes., Conclusions: Our results provide for the first time evidence implicating FGF1 in the occurrence of CL/P, and support TIMP2 and WNT9B as novel loci predisposing to CL/P. We have also replicated recently reported significant associations between variants in or near FOXE1 and CL/P. It is likely that variation in FOXE1, TIMP2, and the FGF and Wnt signaling pathway genes confers susceptibility to nonsyndromic CL/P in Northeastern European populations., (Copyright © 2011 Wiley-Liss, Inc.)

Published
2011
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