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Acquired perforating disorders are a group of uncommon skin conditions characterized by transepidermal extrusion of altered dermal material, most often associated with diabetes mellitus and chronic kidney failure. Delusional parasitosis is a primary psychiatric disorder in which affected patients have fixed, false beliefs that their skin is infested by parasites, in the absence of any evidence supporting their statements.

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Before the discovery of Treponema pallidum as the etiologic agent, the origins of syphilis have been the subject of several debates. Diverse therapeutic agents were employed in an attempt to cure the disease. Examining the milestones in the history of syphilis, the present article reviews the existing theories that tried to explain the origins of the disease, the approach in art, the cultural and the evolution of the treatments from the empiric means to the discovery of penicillin. [ABSTRACT FROM AUTHOR]

Incontinentia pigmenti (IP) is a complex genodermatosis inherited in an X-linked dominant pattern, associating multistadial cutaneous manifestations with an oculo-dento-cerebral syndrome, which affects only female newborns, as the disorder is lethal in males since intrauterine period. We report on a case of incontinentia pigmenti with an atypical debut consisting of tonic-clonic seizures which had started during the first days of life, associated with severe ocular and neurologic manifestations. The presence and severity of extra-cutaneous features most often command the evolution and the prognosis of the disease. [ABSTRACT FROM AUTHOR]

Photodynamic therapy (PDT) is a medical procedure based on the activation of the molecules of various exogenous or endogenous chemical substances called photosensitizers by a light source emitting radiation of an adequate wavelength, usually situated in the visible spectrum; photosensitizers are chemical compounds bearing the capacity to selectively concentrate in the neoplastic cells. The energy captured by the molecules of these substances pervaded in the tumor cells is subsequently discharged in the surrounding tissue, triggering certain photodynamic reactions that result in the destruction of the tumor. The procedure is applicable in numerous medical fields. Skin basal cell carcinoma (BCC), the most frequent type of cancer of the human species, is a cutaneous tumor that responds very well to this innovative treatment method. By reviewing numerous recent studies in the field, this article aims to present the role and the indications of photodynamic therapy in the management of basal cell carcinoma, as well as the most important results achieved so far by this therapy in the field of dermato-oncology. [ABSTRACT FROM AUTHOR]

Photodynamic therapy (PDT) of cancer has been known for over twenty years and is based on the dye-sensitized photooxidation of different biological targets in the tumoral tissue, yielding to a photochemically induced cell's death via mainly apoptotic pathways. The effectiveness of this therapy depends on the photophysical and photochemical properties of the photosensitizer-drug. The purpose of this paper is to evaluate a series of aluminium phthalocyanine sensitizers compounds, in terms of photodynamic activity correlation with their structure using standard human dysplazic oral kerotinocytes cell line (DOK). The photodynamic action of some aluminium sulphonated-phthalocyanines, with different sulphonation degree (AlS2Pc, AlS4Pc), is discussed in this matter. The in vitro photodynamic treatment (PDT) induced a drastic lethal effect on DOK cells attributed to the active singlet oxygen photochemically generated by aluminium sulphonatedphthalocyanines. The tested photosensitizers induce early membrane damage and upon irradiation AlS2Pc compound is the most efficient in actively killing the tumoral cells. [ABSTRACT FROM AUTHOR]

Photodynamic therapy (PDT) is a recent acquisition in the treatment of cutaneous premalignant and malignant lesions, based upon the administration or induction of the synthesis of a photosensitizer in the tumoral tissue, followed by the illumination of the target area using a radiation with an adequate wavelength. This paper aims to review the main molecular, cellular and systemic mechanistic aspects involved in the in vivo effects of PDT, with emphasis on apoptosis and autophagy induction in tumoral cells, local vascular destruction and immune response alteration. [ABSTRACT FROM AUTHOR]

Photodynamic therapy (PDT) is a recent acquisition in the treatment of cutaneous premalignant and malignant lesions, based upon the administration or induction of the synthesis of a photosensitizer in the tumoral tissue, followed by the illumination of the target area using a radiation with an adequate wavelength. This paper aims to review the main molecular, cellular and systemic mechanistic aspects involved in the in vivo effects of PDT, with emphasis on apoptosis and autophagy induction in tumoral cells, local vascular destruction and immune response alteration. [ABSTRACT FROM AUTHOR]

Photodynamic therapy (PDT) is a modern procedure used in dermatology mainly in the treatment of cutaneous malignant tumours (e.g. basal cell carcinoma, squamous cell carcinoma, Kaposis's sarcoma, mycosis fungoides) and premalignant lesions (e.g. actinic keratoses, Bowen's disease, dysplasia and erythroplasia of oral mucosa, erythroplasia of Queyrat). The procedure requires a photosensitiser (PS) able to be selectively accumulated in the tumoral tissue and a light source capable of emitting radiation of an appropriate wavelength in order to activate the photosensitiser. This paper aims at reviewing the basic principles of PDT and the criteria for choosing the photosensitiser, the light source and the adequate values of the physical parameters used in order to obtain optimal therapeutic results with minimal adverse reactions in dermato-oncologic PDT. [ABSTRACT FROM AUTHOR]

Photodynamic therapy (PDT) is a modern procedure used in dermatology mainly in the treatment of cutaneous malignant tumours (e.g. basal cell carcinoma, squamous cell carcinoma, Kaposis's sarcoma, mycosis fungoides) and premalignant lesions (e.g. actinic keratoses, Bowen's disease, dysplasia and erythroplasia of oral mucosa, erythroplasia of Queyrat). The procedure requires a photosensitiser (PS) able to be selectively accumulated in the tumoral tissue and a light source capable of emitting radiation of an appropriate wavelength in order to activate the photosensitiser. This paper aims at reviewing the basic principles of PDT and the criteria for choosing the photosensitiser, the light source and the adequate values of the physical parameters used in order to obtain optimal therapeutic results with minimal adverse reactions in dermato-oncologic PDT. [ABSTRACT FROM AUTHOR]