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1. Guidelines for the Management of Respiratory Infectious Diseases in Children in Japan 2022

Author

Ishiwada, Naruhiko, Shinjoh, Masayoshi, Kusama, Yoshiki, Arakawa, Hirokazu, Ohishi, Tomohiro, Saitoh, Akihiko, Suzuki, Akira, Tsutsumi, Hiroyuki, Nishi, Junichiro, Hoshino, Tadashi, Mitsuda, Toshihiro, Miyairi, Isao, Iwamoto-Kinoshita, Noriko, Kobayashi, Hisato, Satoh, Kouichiro, Shimizu, Akihiko, Takeshita, Kenichi, Tanaka, Takaaki, Tamura, Daisuke, Tokunaga, Osamu, Tomita, Kentaro, Nagasawa, Koo, Funaki, Takanori, Furuichi, Muhehiro, Miyata, Ippei, Yaginuma, Mizuki, Yamaguchi, Yoshio, Yamamoto, Shota, Uehara, Suzuko, Kurosaki, Tomomichi, Okada, Kenji, and Ouchi, Kazunobu

Published
2023
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4. Clinical Evaluation of the Accuracy of the Panbio™ COVID-19/Flu A&B Rapid Panel: A Combination Antigen Rapid Diagnostic Test for the Omicron Variant and Influenza A Virus.

Author

Yamagishi, Hirokazu, Tamura, Daisuke, Yamazaki, Masahiko, Abe, Takashi, Mitamura, Keiko, Tajima, Toshihiro, and Osaka, Hitoshi

Subjects
*SARS-CoV-2, *SARS-CoV-2 Omicron variant, *REVERSE transcriptase polymerase chain reaction, *COVID-19, *RAPID diagnostic tests
Abstract

It is difficult to differentiate between coronavirus disease 2019 (COVID-19) and influenza based on the symptoms. In the present study, a newly developed antigen rapid diagnostic test (Ag-RDT) called Panbio™ COVID-19/Flu A&B that can simultaneously detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A/B virus was evaluated. Its accuracy was evaluated using 235 pairs of nasopharyngeal samples collected from patients with respiratory symptoms and fever (>37.5°C). Reverse transcription polymerase chain reaction was used as a reference method to evaluate the accuracy of the SARS-CoV-2 detection. We confirmed the accuracy of the developed Ag-RDT against the Omicron variant where the sensitivity and specificity were 94.8% and 100%, respectively. In addition, to identify the influenza A virus, a noninferiority test was conducted using a commercial Ag-RDT, which has a sensitivity and specificity in comparison with viral culture of 94.8% and 98.4%, respectively. The positive and negative predictive values for influenza A virus were 98.5% and 98.1%, respectively, for the Panbio COVID-19/Flu A&B test. The evaluation of this newly developed Ag-RDT using clinical samples suggests that it has a high efficacy in clinical settings. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Mechanism of action of adapalene for treating EGFR‐TKI‐induced skin disorder

Author

Mimura, Chihiro, primary, Nagano, Tatsuya, additional, Miwa, Nanako, additional, Matsumura, Kanoko, additional, Yamada, Jun, additional, Satoh, Hiroki, additional, Suraya, Ratoe, additional, Hazama, Daisuke, additional, Tamura, Daisuke, additional, Yamamoto, Masatsugu, additional, Tachihara, Motoko, additional, Nishimura, Yoshihiro, additional, and Kobayashi, Kazuyuki, additional

Published
2024
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6. Temporal Trend of the SARS-CoV-2 Omicron Variant and RSV in the Nasal Cavity and Accuracy of the Newly Developed Antigen-Detecting Rapid Diagnostic Test

Author

Tamura, Daisuke, primary, Morisawa, Yuji, additional, Mato, Takashi, additional, Nunomiya, Shin, additional, Yoshihiro, Masaki, additional, Maehara, Yuta, additional, Ito, Shizuka, additional, Ochiai, Yasushi, additional, Yamagishi, Hirokazu, additional, Tajima, Toshihiro, additional, Yamagata, Takanori, additional, and Osaka, Hitoshi, additional

Published
2024
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7. The first case of hemorrhagic shock and encephalopathy syndrome with fulminant hypercytokinemia associated with pediatric COVID-19

Author

Kurane, Koyuru, primary, Wakae, Keizo, additional, Yamagishi, Hirokazu, additional, Kawahara, Yuta, additional, Ono, Marika, additional, Tamura, Daisuke, additional, Furuya, Kaito, additional, Taga, Naoyuki, additional, Matsuki, Mitsuru, additional, Yamagata, Takanori, additional, and Muramatsu, Kazuhiro, additional

Published
2024
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8. Remarkable proliferative ability of the Omicron variant in the nasal cavity compared to other SARS-CoV-2 variants.

Author

Yamagishi, Hirokazu, Tamura, Daisuke, Morisawa, Yuji, Mato, Takashi, Nunomiya, Shin, Tajima, Toshihiro, and Osaka, Hitoshi

Abstract

Aims: This study analyzed the post-infection viral dynamics of the Alpha, Delta and Omicron variants of severe acute respiratory syndrome coronavirus 2. Patients & methods: Nasopharyngeal samples and anterior nasal samples from patients hospitalized with severe acute respiratory syndrome coronavirus 2 infection were collected and analyzed. Results: Omicron variant specimens from the two sites showed lower threshold cycle (Ct) values, smaller difference in Ct values between the nasopharyngeal samples and anterior nasal samples (ANS) and significantly lower Ct values in the ANS taken within 6 days of disease onset than those of the Alpha and Delta variants. Conclusion: Compared with other variants, the Omicron variant showed more active viral replication in the nasal cavity, which significantly increased in the ANS in early stages of the disease. This study looked at whether the amount of the severe acute respiratory syndrome coronavirus 2 virus in an infected person's blood differed if the person was infected with a different variant of the virus – Alpha, Delta or Omicron. Samples were collected from the back and front of the nose in order to work out how much of the virus was present. Larger amounts of the Omicron variant were found in the front of the nose, particularly in the early stages of illness. This may be because the Omicron variant is more infective. Background This study aimed to clarify the differences in viral dynamics of each severe acute respiratory syndrome coronavirus 2 variant (Alpha, Delta and Omicron variant). Methods Ct values were assayed for samples collected simultaneously from the nasopharyngeal and anterior nasal sites. Results Viral load was higher in the nasopharyngeal site than that in the anterior nasal site for each variant and the difference in viral load between the nasopharyngeal and anterior nasal sites was small in the Omicron variant. Discussion The Omicron variant had a low Ct value in the anterior nasal site during onset, justifying the high infectivity of the Omicron variant. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Temporal Trend of the SARS-CoV-2 Omicron Variant and Res-Piratory Syncytial Virus in the Nasal Cavity and Accuracy of the Newly Developed Antigen-Detecting Rapid Diagnostic Test

Author

Tamura, Daisuke, primary, Morisawa, Yuji, additional, Mato, Takashi, additional, Nunomiya, Shin, additional, Yoshihiro, Masaki, additional, Maehara, Yuta, additional, Ito, Shizuka, additional, Ochiai, Yasushi, additional, Yamagishi, Hirokazu, additional, Tajima, Toshihiro, additional, Yamagata, Takanori, additional, and Osaka, Hitoshi, additional

Published
2023
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16. Supplementary Data from Antitumor Activity of BIBF 1120, a Triple Angiokinase Inhibitor, and Use of VEGFR2+pTyr+ Peripheral Blood Leukocytes as a Pharmacodynamic Biomarker In Vivo

Author

Kudo, Kanae, primary, Arao, Tokuzo, primary, Tanaka, Kaoru, primary, Nagai, Tomoyuki, primary, Furuta, Kazuyuki, primary, Sakai, Kazuko, primary, Kaneda, Hiroyasu, primary, Matsumoto, Kazuko, primary, Tamura, Daisuke, primary, Aomatsu, Keiichi, primary, De Velasco, Marco A., primary, Fujita, Yoshihiko, primary, Saijo, Nagahiro, primary, Kudo, Masatoshi, primary, and Nishio, Kazuto, primary

Published
2023
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17. Supplementary Figure Legends from Sorafenib Inhibits the Hepatocyte Growth Factor–Mediated Epithelial Mesenchymal Transition in Hepatocellular Carcinoma

Author

Nagai, Tomoyuki, primary, Arao, Tokuzo, primary, Furuta, Kazuyuki, primary, Sakai, Kazuko, primary, Kudo, Kanae, primary, Kaneda, Hiroyasu, primary, Tamura, Daisuke, primary, Aomatsu, Keiichi, primary, Kimura, Hideharu, primary, Fujita, Yoshihiko, primary, Matsumoto, Kazuko, primary, Saijo, Nagahiro, primary, Kudo, Masatoshi, primary, and Nishio, Kazuto, primary

Published
2023
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18. Supplementary Figures 1-5 from Sorafenib Inhibits the Hepatocyte Growth Factor–Mediated Epithelial Mesenchymal Transition in Hepatocellular Carcinoma

Author

Nagai, Tomoyuki, primary, Arao, Tokuzo, primary, Furuta, Kazuyuki, primary, Sakai, Kazuko, primary, Kudo, Kanae, primary, Kaneda, Hiroyasu, primary, Tamura, Daisuke, primary, Aomatsu, Keiichi, primary, Kimura, Hideharu, primary, Fujita, Yoshihiko, primary, Matsumoto, Kazuko, primary, Saijo, Nagahiro, primary, Kudo, Masatoshi, primary, and Nishio, Kazuto, primary

Published
2023
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20. Supplementary Figure Legend from FOXQ1 Is Overexpressed in Colorectal Cancer and Enhances Tumorigenicity and Tumor Growth

Author

Kaneda, Hiroyasu, primary, Arao, Tokuzo, primary, Tanaka, Kaoru, primary, Tamura, Daisuke, primary, Aomatsu, Keiichi, primary, Kudo, Kanae, primary, Sakai, Kazuko, primary, De Velasco, Marco A., primary, Matsumoto, Kazuko, primary, Fujita, Yoshihiko, primary, Yamada, Yasuhide, primary, Tsurutani, Junji, primary, Okamoto, Isamu, primary, Nakagawa, Kazuhiko, primary, and Nishio, Kazuto, primary

Published
2023
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21. Supplementary Figure 1 from FOXQ1 Is Overexpressed in Colorectal Cancer and Enhances Tumorigenicity and Tumor Growth

Author

Kaneda, Hiroyasu, primary, Arao, Tokuzo, primary, Tanaka, Kaoru, primary, Tamura, Daisuke, primary, Aomatsu, Keiichi, primary, Kudo, Kanae, primary, Sakai, Kazuko, primary, De Velasco, Marco A., primary, Matsumoto, Kazuko, primary, Fujita, Yoshihiko, primary, Yamada, Yasuhide, primary, Tsurutani, Junji, primary, Okamoto, Isamu, primary, Nakagawa, Kazuhiko, primary, and Nishio, Kazuto, primary

Published
2023
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23. Data from FOXQ1 Is Overexpressed in Colorectal Cancer and Enhances Tumorigenicity and Tumor Growth

Author

Kaneda, Hiroyasu, primary, Arao, Tokuzo, primary, Tanaka, Kaoru, primary, Tamura, Daisuke, primary, Aomatsu, Keiichi, primary, Kudo, Kanae, primary, Sakai, Kazuko, primary, De Velasco, Marco A., primary, Matsumoto, Kazuko, primary, Fujita, Yoshihiko, primary, Yamada, Yasuhide, primary, Tsurutani, Junji, primary, Okamoto, Isamu, primary, Nakagawa, Kazuhiko, primary, and Nishio, Kazuto, primary

Published
2023
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25. Supplementary Tables 1-2 from FOXQ1 Is Overexpressed in Colorectal Cancer and Enhances Tumorigenicity and Tumor Growth

Author

Kaneda, Hiroyasu, primary, Arao, Tokuzo, primary, Tanaka, Kaoru, primary, Tamura, Daisuke, primary, Aomatsu, Keiichi, primary, Kudo, Kanae, primary, Sakai, Kazuko, primary, De Velasco, Marco A., primary, Matsumoto, Kazuko, primary, Fujita, Yoshihiko, primary, Yamada, Yasuhide, primary, Tsurutani, Junji, primary, Okamoto, Isamu, primary, Nakagawa, Kazuhiko, primary, and Nishio, Kazuto, primary

Published
2023
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31. High Quality Autostereoscopic Surgical Display Using Anti-aliased Integral Videography Imaging

Author

Liao, Hongen, Tamura, Daisuke, Iwahara, Makoto, Hata, Nobuhiko, Dohi, Takeyoshi, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Barillot, Christian, editor, Haynor, David R., editor, and Hellier, Pierre, editor

Published
2004
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35. Perinatal Management in a Pregnant Woman with Ureteropelvic Junction Obstruction: Case Report and Literature Review

Author

Tamura, Daisuke, primary, Narita, Shintaro, additional, Yamauchi, Misa, additional, Watanabe, Rina, additional, Yokoyama, Shota, additional, Kikuchi, Akane, additional, Shitara, Akihiro, additional, Chiba, Syuji, additional, Saito, Fumiko, additional, Sugita, Akihiro, additional, Sato, Kazunari, additional, and Karube, Akihiro, additional

Published
2022
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40. Fatal Hemoptysis Due to Endobronchial Aspergilloma in the Hyperinflated Native Lung after Single-Lung Transplantation for Lymphangioleiomyomatosis: A Case Report

Author

Yoshizaki, Asuka, Yamamoto, Masatsugu, Hirabayashi, Aya, Ono, Yoshihiko, Hatakeyama, Yukihisa, Nakata, Kyosuke, Tamura, Daisuke, Tachihara, Motoko, Kamiryo, Hiroshi, Kobayashi, Kazuyuki, Nishio, Mari, and Nishimura, Yoshihiro

Subjects
respiratory system, skin and connective tissue diseases, respiratory tract diseases
Published
2019

42. Effect of Bronchial Thermoplasty on Air Trapping Assessed by Xenon Ventilation Computed Tomography

Author

Dokuni, Ryota, primary, Kobayashi, Kazuyuki, additional, Ohno, Yoshiharu, additional, Nagano, Tatsuya, additional, Tamura, Daisuke, additional, Umezawa, Kanoko, additional, Katsurada, Naoko, additional, Nakata, Kyosuke, additional, Yamamoto, Masatsugu, additional, Tachihara, Motoko, additional, Kamiryo, Hiroshi, additional, and Nishimura, Yoshihiro, additional

Published
2021
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46. In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses

Author

Itoh, Yasushi, Shinya, Kyoko, Kiso, Maki, Watanabe, Tokiko, Sakoda, Yoshihiro, Hatta, Masato, Muramoto, Yukiko, Tamura, Daisuke, Sakai-Tagawa, Yuko, Noda, Takeshi, Sakabe, Saori, Imai, Masaki, Hatta, Yasuko, Watanabe, Shinji, Li, Chengjun, Yamada, Shinya, Fujii, Ken, Murakami, Shin, Imai, Hirotaka, Kakugawa, Satoshi, Ito, Mutsumi, Takano, Ryo, Iwatsuki-Horimoto, Kiyoko, Shimojima, Masayuki, Horimoto, Taisuke, Goto, Hideo, Takahashi, Kei, Makino, Akiko, Ishigaki, Hirohito, Nakayama, Misako, Okamatsu, Masatoshi, Takahashi, Kazuo, Warshauer, David, Shult, Peter A., Saito, Reiko, Suzuki, Hiroshi, Furuta, Yousuke, Yamashita, Makoto, Mitamura, Keiko, Nakano, Kunio, Nakamura, Morio, Brockman-Schneider, Rebecca, Mitamura, Hiroshi, Yamazaki, Masahiko, Sugaya, Norio, Suresh, M., Ozawa, Makoto, Neumann, Gabriele, Gern, James, Kida, Hiroshi, Ogasawara, Kazumasa, and Kawaoka, Yoshihiro

Published
2009
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50. Feasibility Study of Adjuvant Chemotherapy with Carboplatin and Nab-Paclitaxel for Completely Resected NSCLC

Author

Katsurada, Naoko, Tachihara, Motoko, Hatakeyama, Yukihisa, Koyama, Kiyoko, Yumura, Masako, Kiriu, Tatsunori, Dokuni, Ryota, Hazama, Daisuke, Tokunaga, Shuntaro, Tamura, Daisuke, Nakata, Kyosuke, Yamamoto, Masatsugu, Kamiryo, Hiroshi, Kobayashi, Kazuyuki, Tanaka, Yugo, Maniwa, Yoshimasa, and Nishimura, Yoshihiro

Subjects
adjuvant chemotherapy, nab-paclitaxel, Clinical Trial Report, Cancer Management and Research, carboplatin, non-small cell cancer
Abstract

Naoko Katsurada,1 Motoko Tachihara,1 Yukihisa Hatakeyama,1 Kiyoko Koyama,1 Masako Yumura,1 Tatsunori Kiriu,1 Ryota Dokuni,1 Daisuke Hazama,1 Shuntaro Tokunaga,1 Daisuke Tamura,1 Kyosuke Nakata,1 Masatsugu Yamamoto,1 Hiroshi Kamiryo,1 Kazuyuki Kobayashi,1 Yugo Tanaka,2 Yoshimasa Maniwa,2 Yoshihiro Nishimura1 1Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan; 2Division of General Theocratic Surgery, Kobe University Graduate School of Medicine, Kobe, JapanCorrespondence: Motoko TachiharaDivision of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, JapanTel +81-78-382-5660Fax +81-78-382-5661Email mt0318@med.kobe-u.ac.jpPurpose: Adjuvant chemotherapy with cisplatin (CDDP) plus vinorelbine is the standard regimen for the treatment of non-small cell lung cancer (NSCLC). However, CDDP elicits severe toxic effects, including emesis, neurotoxicity, and renal damage; carboplatin (CBDCA) may be a feasible alternative for CDDP-unfit patients. CBDCA plus paclitaxel (PTX) adjuvant chemotherapy showed a survival benefit for patients with stage IB tumors > 4 cm in size, while CBDCA plus nanoparticle albumin-bound (nab)-PTX showed greater efficacy and lower neurotoxicity than CBDCA plus PTX in advanced NSCLC. Here, we investigated the feasibility of using CBDCA plus nab-PTX as adjuvant chemotherapy for NSCLC.Patients and Methods: Patients with completely resected stage II or III NSCLC, with an Eastern Cooperative Oncology Group performance status of 0– 1 and adequate kidney function, received four cycles of postoperative adjuvant chemotherapy with CBDCA (AUC=5 mg/mL/min, on day 1) and nab-PTX (100 mg/m2, on days 1, 8, and 15) administered every 4 weeks within 8 weeks after surgery. The study was designed as a prospective, single-center, Phase II study. The primary endpoint was the completion rate of chemotherapy; secondary endpoints were two-year relapse-free survival (RFS) and safety. The expected completion rate was 80%, with a 50% lower limit.Results: Of 21 enrolled patients, 18 (85.7%) were CDDP-unfit owing to age (≥ 75 years old [n=11, 52.4%]) or mild renal impairment (n=7, 33.3%). Nineteen of the 21 enrolled patients were assigned to the intervention. The most common grade 3 or 4 adverse events were neutropenia (n=15, 78.9%) and anemia (n=3, 15.8%). The completion rate for the four cycles was 63.2% (95% CI, 38.4– 83.7). Two-year RFS was 56.8% (95% CI, 29.7– 76.9).Conclusion: The completion rate for CBDCA plus nab-PTX as adjuvant chemotherapy for CDDP-unfit NSCLC patients did not reach treatment feasibility. Further dose modifications may be required in future studies.Keywords: nab-paclitaxel, carboplatin, adjuvant chemotherapy, non-small cell cancer

Published
2020

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