1. Collagen I and III Ratios and Tenacity of Rats' Muscle Injured and Treated with Platelet-Rich Plasma
- Author
-
Garcia, Thiago Alves, Tamura Ozaki, Guilherme Akio [UNESP], Castoldi, Robson Chacon, Job, Aldo Eloizo [UNESP], Trindade Camargo, Regina Celi [UNESP], Silva Camargo Filho, Jose Carlos [UNESP], Belangero, William Dias, Universidade Estadual de Campinas (UNICAMP), Universidade Estadual Paulista (Unesp), and Univ Oeste Paulista
- Subjects
Platelet-rich plasma ,Muscle injury ,Collagen ,Suture - Abstract
Made available in DSpace on 2021-06-25T12:18:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-10-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Universidade do Oeste Paulista (Unoeste) Severe muscle injuries are common in accidents and have a delayed recovery of muscle integrity. In these cases, muscle suture surgery is the standard treatment. However, Platelet Rich Plasma (PRP), has been widely used in orthopedic injuries due to its growth factors. Thus, the objective of the study will be to analyze the association of suture and PRP techniques in the collagen and tenacity of the injured muscle. Were used seventy rats, divided into five groups: control (C), injury control (CI), injury and suture (IS), injury and PRP (IP), injury, suture, and PRP (ISP). Were sectioned approximately 50 % of the width and 100 % of the thickness of the gastrocnemius muscle. The homologous PRP was applied 24h after the injury. On the 7th day after the injury, the animals were euthanized and their muscles subjected to mechanical testing to measure tenacity or collagen analysis to calculate the ratio between type I and III collagen. The results show a significant decrease (p
- Published
- 2020