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6. The ongoing Streptococcus pyogenes (Group A Streptococcus) outbreak in London, United Kingdom, in December 2022: a molecular epidemiology study

Author

Athitha, Vasanthini, Begum, Jahaedea, Bonaiti, Massimo, Brennan, Julie, Bryan, Lisa, Cerda, Albert, Cliff, Penelope R., Hoang, Luong Huw, Merrill, Tammy V., Naumova, Denitsa, Parvez, Rayhan, Valle, Kristine, White, Sarah, Wray, Diane, Alcolea-Medina, Adela, Snell, Luke B., Alder, Christopher, Charalampous, Themoula, Williams, Tom G.S., Tan, Mark K.I., Al-Yaakoubi, Noor, Humayun, Gul, Newsholme, William, Goldenberg, Simon, Nebbia, Gaia, Neil, Stuart J.D., Batra, Rahul, and Edgeworth, Jonathan D.

Published
2023
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14. Retraction Note: Graded bandgap perovskite solar cells

Author

Ergen, Onur, Gilbert, S Matt, Pham, Thang, Turner, Sally J, Tan, Mark Tian Zhi, Worsley, Marcus A, and Zettl, Alex

Subjects
Engineering, Chemical Sciences, Physical Chemistry, Nanoscience & Nanotechnology
Abstract

This corrects the article DOI: 10.1038/nmat4795.

Published
2018

15. Retraction: Graded bandgap perovskite solar cells.

Author

Ergen, Onur, Gilbert, S Matt, Pham, Thang, Turner, Sally J, Tan, Mark Tian Zhi, Worsley, Marcus A, and Zettl, Alex

Subjects
Nanoscience & Nanotechnology
Abstract

This corrects the article DOI: 10.1038/nmat4795.

Published
2018

16. Supplementary Table S3 from Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma

Author

Gleason, Caroline E., primary, Dickson, Mark A., primary, Klein (Dooley), Mary E., primary, Antonescu, Cristina R., primary, Gularte-Mérida, Rodrigo, primary, Benitez, Marimar, primary, Delgado, Juliana I., primary, Kataru, Raghu P., primary, Tan, Mark Wei Yi, primary, Bradic, Martina, primary, Adamson, Travis E., primary, Seier, Kenneth, primary, Richards, Allison L., primary, Palafox, Marta, primary, Chan, Eric, primary, D'Angelo, Sandra P., primary, Gounder, Mrinal M., primary, Keohan, Mary Louise, primary, Kelly, Ciara M., primary, Chi, Ping, primary, Movva, Sujana, primary, Landa, Jonathan, primary, Crago, Aimee M., primary, Donoghue, Mark T.A., primary, Qin, Li-Xuan, primary, Serra, Violetta, primary, Turkekul, Mesruh, primary, Barlas, Afsar, primary, Firester, Daniel M., primary, Manova-Todorova, Katia, primary, Mehrara, Babak J., primary, Kovatcheva, Marta, primary, Tan, Nguan Soon, primary, Singer, Samuel, primary, Tap, William D., primary, and Koff, Andrew, primary

Published
2024
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17. Supplementary Figure S15 from Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma

Author

Gleason, Caroline E., primary, Dickson, Mark A., primary, Klein (Dooley), Mary E., primary, Antonescu, Cristina R., primary, Gularte-Mérida, Rodrigo, primary, Benitez, Marimar, primary, Delgado, Juliana I., primary, Kataru, Raghu P., primary, Tan, Mark Wei Yi, primary, Bradic, Martina, primary, Adamson, Travis E., primary, Seier, Kenneth, primary, Richards, Allison L., primary, Palafox, Marta, primary, Chan, Eric, primary, D'Angelo, Sandra P., primary, Gounder, Mrinal M., primary, Keohan, Mary Louise, primary, Kelly, Ciara M., primary, Chi, Ping, primary, Movva, Sujana, primary, Landa, Jonathan, primary, Crago, Aimee M., primary, Donoghue, Mark T.A., primary, Qin, Li-Xuan, primary, Serra, Violetta, primary, Turkekul, Mesruh, primary, Barlas, Afsar, primary, Firester, Daniel M., primary, Manova-Todorova, Katia, primary, Mehrara, Babak J., primary, Kovatcheva, Marta, primary, Tan, Nguan Soon, primary, Singer, Samuel, primary, Tap, William D., primary, and Koff, Andrew, primary

Published
2024
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18. Data from Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma

Author

Gleason, Caroline E., primary, Dickson, Mark A., primary, Klein (Dooley), Mary E., primary, Antonescu, Cristina R., primary, Gularte-Mérida, Rodrigo, primary, Benitez, Marimar, primary, Delgado, Juliana I., primary, Kataru, Raghu P., primary, Tan, Mark Wei Yi, primary, Bradic, Martina, primary, Adamson, Travis E., primary, Seier, Kenneth, primary, Richards, Allison L., primary, Palafox, Marta, primary, Chan, Eric, primary, D'Angelo, Sandra P., primary, Gounder, Mrinal M., primary, Keohan, Mary Louise, primary, Kelly, Ciara M., primary, Chi, Ping, primary, Movva, Sujana, primary, Landa, Jonathan, primary, Crago, Aimee M., primary, Donoghue, Mark T.A., primary, Qin, Li-Xuan, primary, Serra, Violetta, primary, Turkekul, Mesruh, primary, Barlas, Afsar, primary, Firester, Daniel M., primary, Manova-Todorova, Katia, primary, Mehrara, Babak J., primary, Kovatcheva, Marta, primary, Tan, Nguan Soon, primary, Singer, Samuel, primary, Tap, William D., primary, and Koff, Andrew, primary

Published
2024
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24. High current, high efficiency graded band gap perovskite solar cells

Author

Ergen, Onur, Gilbert, S. Matt, Pham, Thang, Turner, Sally J., Tan, Mark Tian Zhi, Worsley, Marcus A., and Zettl, Alex

Subjects
Condensed Matter - Materials Science
Abstract

Organic-inorganic halide perovskite materials have emerged as attractive alternatives to conventional solar cell building blocks. Their high light absorption coefficients and long diffusion lengths suggest high power conversion efficiencies (PCE),1-5 and indeed perovskite-based single band gap and tandem solar cell designs have yielded impressive performances.1-16 One approach to further enhance solar spectrum utilization is the graded band gap, but this has not been previously achieved for perovskites. In this study, we demonstrate graded band gap perovskite solar cells with steady-state conversion efficiencies averaging 18.4%, with a best of 21.7%, all without reflective coatings. An analysis of the experimental data yields high fill factors of ~75% and high short circuit current densities up to 42.1 mA/cm2. These cells, which are based on a novel architecture of two perovskite layers (MASnI3 and MAPbI3-xBrx), incorporating GaN, monolayer hexagonal boron nitride, and graphene aerogel, display the highest efficiency ever reported for perovskite solar cells., Comment: 19 pages, 4 figures, supplementary information available upon requet

Published
2016

27. Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans

Author

Seow, Jeffrey, Graham, Carl, Merrick, Blair, Acors, Sam, Pickering, Suzanne, Steel, Kathryn J. A., Hemmings, Oliver, O’Byrne, Aoife, Kouphou, Neophytos, Galao, Rui Pedro, Betancor, Gilberto, Wilson, Harry D., Signell, Adrian W., Winstone, Helena, Kerridge, Claire, Huettner, Isabella, Jimenez-Guardeño, Jose M., Lista, Maria Jose, Temperton, Nigel, Snell, Luke B., Bisnauthsing, Karen, Moore, Amelia, Green, Adrian, Martinez, Lauren, Stokes, Brielle, Honey, Johanna, Izquierdo-Barras, Alba, Arbane, Gill, Patel, Amita, Tan, Mark Kia Ik, O’Connell, Lorcan, O’Hara, Geraldine, MacMahon, Eithne, Douthwaite, Sam, Nebbia, Gaia, Batra, Rahul, Martinez-Nunez, Rocio, Shankar-Hari, Manu, Edgeworth, Jonathan D., Neil, Stuart J. D., Malim, Michael H., and Doores, Katie J.

Published
2020
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28. Routine Metagenomics Service for Intensive Care Unit Patients with Respiratory Infection

Author

Charalampous, Themoula, primary, Aloclea-Medina, Adela, additional, Snell, Luke B., additional, Alder, Christopher, additional, Tan, Mark, additional, Williams, Tom G. S., additional, Al-Yaakoubi, Noor, additional, Humayun, Gul, additional, Meadows, Christopher I S, additional, Wyncoll, Duncan L.A., additional, Paul, Richard, additional, Hemsley, Carolyn J., additional, Jeyaratnam, Dakshika, additional, Newsholme, William, additional, Goldenberg, Simon, additional, Patel, Amita, additional, Tucker, Fearghal, additional, Nebbia, Gaia, additional, Wilks, Mark, additional, Chand, Meera, additional, Cliff, Penelope R., additional, Batra, Rahul, additional, O'Grady, Justin, additional, Barrett, Nicholas A., additional, and Edgeworth, Jonathan D., additional

Published
2023
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29. Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma

Author

Gleason, Caroline E., primary, Dickson, Mark A., additional, Klein (Dooley), Mary E., additional, Antonescu, Cristina R., additional, Gularte-Mérida, Rodrigo, additional, Benitez, Marimar, additional, Delgado, Juliana I., additional, Kataru, Raghu P., additional, Tan, Mark Wei Yi, additional, Bradic, Martina, additional, Adamson, Travis E., additional, Seier, Kenneth, additional, Richards, Allison L., additional, Palafox, Marta, additional, Chan, Eric, additional, D'Angelo, Sandra P., additional, Gounder, Mrinal M., additional, Keohan, Mary Louise, additional, Kelly, Ciara M., additional, Chi, Ping, additional, Movva, Sujana, additional, Landa, Jonathan, additional, Crago, Aimee M., additional, Donoghue, Mark T.A., additional, Qin, Li-Xuan, additional, Serra, Violetta, additional, Turkekul, Mesruh, additional, Barlas, Afsar, additional, Firester, Daniel M., additional, Manova-Todorova, Katia, additional, Mehrara, Babak J., additional, Kovatcheva, Marta, additional, Tan, Nguan Soon, additional, Singer, Samuel, additional, Tap, William D., additional, and Koff, Andrew, additional

Published
2023
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35. Routine Metagenomics Service for ICU Patients with Respiratory Infection.

Author

Charalampous, Themoula, Alcolea-Medina, Adela, Snell, Luke B., Alder, Christopher, Tan, Mark, Williams, Tom G. S., Al-Yaakoubi, Noor, Humayun, Gul, Meadows, Christopher I. S., Wyncoll, Duncan L. A., Paul, Richard, Hemsley, Carolyn J., Jeyaratnam, Dakshika, Newsholme, William, Goldenberg, Simon, Patel, Amita, Tucker, Fearghal, Nebbia, Gaia, Wilks, Mark, and Chand, Meera

Subjects
METAGENOMICS, RESPIRATORY infections, STREPTOCOCCUS pyogenes, LEGIONELLA pneumophila, INFECTION control
Abstract

Rationale: Respiratory metagenomics (RMg) needs evaluation in a pilot service setting to determine utility and inform implementation into routine clinical practice. Objectives: Feasibility, performance, and clinical impacts on antimicrobial prescribing and infection control were recorded during a pilot RMg service. Methods: RMg was performed on 128 samples from 87 patients with suspected lower respiratory tract infection (LRTI) on two general and one specialist respiratory ICUs at Guy’s and St Thomas’ NHS Foundation Trust, London. Measurements and Main Results: During the first 15 weeks, RMg provided same-day results for 110 samples (86%), with a median turnaround time of 6.7 hours (interquartile range = 6.1–7.5 h). RMg was 93% sensitive and 81% specific for clinically relevant pathogens compared with routine testing. Forty-eight percent of RMg results informed antimicrobial prescribing changes (22% escalation; 26% deescalation) with escalation based on speciation in 20 out of 24 cases and detection of acquired-resistance genes in 4 out of 24 cases. Fastidious or unexpected organisms were reported in 21 samples, including anaerobes (n = 12), Mycobacterium tuberculosis, Tropheryma whipplei, cytomegalovirus, and Legionella pneumophila ST1326, which was subsequently isolated from the bedside water outlet. Application to consecutive severe community-acquired LRTI cases identified Staphylococcus aureus (two with SCCmec and three with luk F/S virulence determinants), Streptococcus pyogenes (emm1-M1uk clone), S. dysgalactiae subspecies equisimilis (STG62647A), and Aspergillus fumigatus with multiple treatments and public health impacts. Conclusions: This pilot study illustrates the potential of RMg testing to provide benefits for antimicrobial treatment, infection control, and public health when provided in a real-world critical care setting. Multicenter studies are now required to inform future translation into routine service. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Care for the Environment as a Consideration in Bioethics Discourse and Education.

Author

Calderon, Pacifico Eric Eusebio and Tan, Mark Kiak Min

Subjects
*ENVIRONMENTAL ethics, *BIOETHICS, *MEDICAL ethics, *MEDICAL education, *POISONS
Abstract

This article argues that environmental considerations fall within the scope of medical bioethics, and there are implications specific to medical education. It endorses the need to expand the scope and epistemology of contemporary medical bioethics discourse by including themes related to environmental considerations. Our discussion begins by providing a brief history of environmental bioethics. It then offers a critique of three specific health and environmental issues, namely technology, toxics, and consumption, and discusses how these issues are key to articulating moral considerations of human health and subsequently medicine and its teaching. Lastly, it explores criticisms of including environmental issues into the bioethical debate before providing suggestions of how environmental ethics can be included into the medical curriculum. This article concludes by suggesting theoretical possibilities for environmentally inclusive bioethics, such as reorienting bioethical discussions to its original environmental advocacy and supporting environmental bioethics as a competency in medical education. [ABSTRACT FROM AUTHOR]

Published
2023
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37. The ongoing Streptococcus pyogenes (Group A Streptococcus) outbreak in London, United Kingdom, in December 2022: a molecular epidemiology study

Author

Alcolea-Medina, Adela, primary, Snell, Luke B., additional, Alder, Christopher, additional, Charalampous, Themoula, additional, Williams, Tom G.S., additional, Tan, Mark K.I., additional, Al-Yaakoubi, Noor, additional, Humayun, Gul, additional, Newsholme, William, additional, Goldenberg, Simon, additional, Nebbia, Gaia, additional, Neil, Stuart J.D., additional, Batra, Rahul, additional, Edgeworth, Jonathan D., additional, Athitha, Vasanthini, additional, Begum, Jahaedea, additional, Bonaiti, Massimo, additional, Brennan, Julie, additional, Bryan, Lisa, additional, Cerda, Albert, additional, Cliff, Penelope R., additional, Hoang, Luong Huw, additional, Merrill, Tammy V., additional, Naumova, Denitsa, additional, Parvez, Rayhan, additional, Valle, Kristine, additional, White, Sarah, additional, and Wray, Diane, additional

Published
2023
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38. Routine respiratory metagenomics service for intensive care unit patients

Author

CHARALAMPOUS, THEMOULA, primary, Alcolea-Medina, Adela, additional, Snell, Luke B., additional, Alder, Christopher, additional, Tan, Mark, additional, Williams, Tom G.S., additional, Al-Yaakoubi, Noor, additional, Humayun, Gul, additional, Meadows, Christopher I.S., additional, Wyncoll, Duncan L.A., additional, Richard, Paul, additional, Hemsley, Carolyn J., additional, Jeyaratnam, Dakshika, additional, Newsholme, William, additional, Goldenberg, Simon, additional, Patel, Amita, additional, Tucker, Fearghal, additional, Nebbia, Gaia, additional, Wilks, Mark, additional, Chand, Meera, additional, Cliff, Penelope R., additional, Batra, Rahul, additional, O"Grady, Justin, additional, Barrett, Nicholas A., additional, and Edgeworth, Jonathan D, additional

Published
2023
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