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1. Harmonizing data across the accelerating colorectal cancer screening and follow-up through implementation science (ACCSIS) program to enhance data quality and promote data sharing

Author

Subramanian, Sujha, Kobrin, Sarah, Hoover, Sonja, Tan, Sylvia, Brenner, Alison T., Campbell, Janis E., Hatcher, Jennifer, Huang, Bin, Jones, Madeleine, Kenzie, Erin S., Lam, Helen, Liebovitz, David, Mishra, Shiraz I., O’Leary, Meghan C., Ortwine, Kristine N., Pankratz, V. Shane, Paskett, Electra D., Pennell, Michael, Petrik, Amanda F., and Roesch, Scott

Published
2024
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4. Reducing perceived barriers to scaling up overdose education and naloxone distribution and medications for opioid use disorder in the United States in the HEALing (Helping End Addiction Long-Term®) communities study

Author

Knudsen, Hannah K., Walker, Daniel M., Mack, Nicole, Kinnard, Elizabeth N., Huerta, Timothy R., Glasgow, LaShawn, Gilbert, Louisa, Garner, Bryan R., Dasgupta, Anindita, Chandler, Redonna, Walsh, Sharon L., Tin, Yjuliana, Tan, Sylvia, Sprunger, Joel, Sprague-Martinez, Linda, Salsberry, Pamela, Saucier, Merielle, Rudorf, Maria, Rodriguez, Sandra, Oser, Carrie B., Oga, Emmanuel, Nakayima, Julie, Linas, Beth S., Lefebvre, R. Craig, Kosakowski, Sarah, Katz, Rachel E., Hunt, Timothy, Holman, Ari, Holloway, JaNae, Goddard-Eckrich, Dawn, Fareed, Naleef, Christopher, Mia, Aldrich, Alison, Adams, Joella W., and Drainoni, Mari-Lynn

Published
2024
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5. Serum ferritin values in neonates <29 weeks’ gestation are highly variable and do not correlate with reticulocyte hemoglobin content

Author

Bahr, Timothy M., Tan, Sylvia, Smith, Emily, Beauman, Sandra S., Schibler, Kurt R., Grisby, Cathy A., Lowe, Jean R., Bell, Edward F., Laptook, Abbot R., Shankaran, Seetha, Carlton, David P., Rau, Carrie, Baserga, Mariana C., Flibotte, John, Zaterka-Baxter, Kristin, Walsh, Michele C., Das, Abhik, Christensen, Robert D., and Ohls, Robin K.

Published
2023
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6. Effects of the Communities that Heal (CTH) intervention on perceived opioid-related community stigma in the HEALing Communities Study: results of a multi-site, community-level, cluster-randomized trial

Author

Davis, Alissa, Knudsen, Hannah K., Walker, Daniel M., Chassler, Deborah, Lunze, Karsten, Westgate, Philip M., Oga, Emmanuel, Rodriguez, Sandra, Tan, Sylvia, Holloway, JaNae, Walsh, Sharon L., Oser, Carrie B., Lefebvre, R. Craig, Fanucchi, Laura C., Glasgow, LaShawn, McAlearney, Ann Scheck, Surratt, Hilary L., Konstan, Michael W., Huang, Terry T.-K., LeBaron, Patricia, Nakayima, Julie, Stein, Michael D., Rudorf, Maria, Nouvong, Monica, Kinnard, Elizabeth N., El-Bassel, Nabila, Tilley, Jess, Macoubray, Aaron, Savitzky, Caroline, Farmer, Amy, Beers, Donna, Salsberry, Pamela, and Huerta, Timothy R.

Published
2024
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7. Community-level determinants of stakeholder perceptions of community stigma toward people with opioid use disorders, harm reduction services and treatment in the HEALing Communities Study

Author

Davis, Alissa, Stringer, Kristi Lynn, Drainoni, Mari-Lynn, Oser, Carrie B., Knudsen, Hannah K., Aldrich, Alison, Surratt, Hilary L., Walker, Daniel M., Gilbert, Louisa, Downey, Dget L., Gardner, Sam D., Tan, Sylvia, Lines, Lisa M., Vandergrift, Nathan, Mack, Nicole, Holloway, JaNae, Lunze, Karsten, McAlearney, Ann Scheck, Huerta, Timothy R., Goddard-Eckrich, Dawn A., and El-Bassel, Nabila

Published
2023
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8. Maternal and perinatal outcomes of women with vaginal birth after cesarean section compared to repeat cesarean birth in select South Asian and Latin American settings of the global network for women’s and children’s health research

Author

Figueroa, Lester, Harrison, Margo, Mazariegos, Manolo, Goudar, Shivaprasad, Kavi, Avinash, Derman, Richard, Patel, Archana, Das, Prabir, Hibberd, Patricia L., Saleem, Sarah, Naqvi, Farnaz, Goldenberg, Robert L., Haque, Rashidul, Billah, Sk Masum, Petri, Jr., William A., McClure, Elizabeth M., Tan, Sylvia, and Krebs, Nancy F.

Published
2023
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9. Early brain and abdominal oxygenation in extremely low birth weight infants

Author

Chock, Valerie Y., Smith, Emily, Tan, Sylvia, Ball, M. Bethany, Das, Abhik, Hintz, Susan R., Kirpalani, Haresh, Bell, Edward F., Chalak, Lina F., Carlo, Waldemar A., Cotten, C. Michael, Widness, John A., Kennedy, Kathleen A., Ohls, Robin K., Seabrook, Ruth B., Patel, Ravi M., Laptook, Abbot R., Mancini, Toni, Sokol, Gregory M., Walsh, Michele C., Yoder, Bradley A., Poindexter, Brenda B., Chawla, Sanjay, D’Angio, Carl T., Higgins, Rosemary D., and Van Meurs, Krisa P.

Published
2022
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10. The epidemiology of platelet transfusions: an analysis of platelet use at 12 US hospitals

Author

Gottschall, Jerome, Wu, YanYun, Triulzi, Darrell, Kleinman, Steven, Strauss, Ronald, Zimrin, Ann Butler, McClure, Christopher, Tan, Sylvia, Bialkowski, Walter, Murphy, Edward, Ness, Paul, and Study, for the NHLBI Recipient Epidemiology and Donor Evaluation

Subjects
Rare Diseases, Hematology, Cancer, Patient Safety, Clinical Research, Blood, Aged, Female, Hospitals, Humans, Leukemia, Lymphoma, Male, Middle Aged, Myelodysplastic Syndromes, Platelet Transfusion, Plateletpheresis, Retrospective Studies, United States, NHLBI Recipient Epidemiology and Donor Evaluation (REDS-III) Study, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Immunology, Cardiovascular System & Hematology
Abstract

BackgroundUsing the Recipient and Donor Epidemiology Study-III (REDS-III) recipient and donor databases, we performed a retrospective analysis of platelet use in 12 US hospitals that were participants in REDS-III.Study design and methodsData were electronically extracted from participating transfusion service and blood center computer systems and from medical records of the 12 REDS-III hospitals. All platelet transfusions from 2013 to 2016 given to patients aged 18 years and older were included in the analysis.ResultsThere were 28,843 inpatients and 2987 outpatients who were transfused with 163,719 platelet products (103,371 apheresis, 60,348 whole blood derived); 93.5% of platelets were leukoreduced and 72.5% were irradiated. Forty-six percent were transfused to patients with an International Classification of Diseases, 9th/10th Revision (ICD-9/10) diagnosis of leukemia, myelodysplastic syndrome (MDS), or lymphoma. The general ward and the intensive care unit (ICU) were the most common issue locations. Only 54% of platelet transfusions were ABO identical; and 60.6% of platelet transfusions given to Rh-negative patients were Rh positive. The most common pretransfusion platelet count range for inpatients was 20,000 to 50,000/μL, for outpatients it was 10,000 to 20,000/μL. Among ICU patients, 35% of platelet transfusion episodes had a platelet count of greater than 50,000/μL; this was only 8% for general ward and 2% for outpatients. The median posttransfusion increment, not corrected for platelet dose and/or patient size, ranged from 12,000 to 20,000/μL for inpatients, and from 17,000 to 27,000/μL for outpatients.ConclusionsThese data from one of the largest reviews of platelet transfusion practice to date provide guidance for where to focus future clinical research studies and platelet blood management programs.

Published
2020

11. Equivalent inpatient mortality among direct-acting oral anticoagulant and warfarin users presenting with major hemorrhage

Author

Bialkowski, Walter, Tan, Sylvia, Mast, Alan E, Kiss, Joseph E, Kor, Daryl, Gottschall, Jerome, Wu, Yanyun, Roubinian, Nareg, Triulzi, Darrell, Kleinman, Steve, Choi, Young, Brambilla, Donald, Zimrin, Ann, and Study, the NHLBI Recipient Epidemiology and Donor Evaluation-III

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Physical Injury - Accidents and Adverse Effects, Clinical Research, Good Health and Well Being, Administration, Oral, Anticoagulants, Atrial Fibrillation, Blood Component Transfusion, Factor Xa Inhibitors, Hemorrhage, Humans, Inpatients, Plasma, Retrospective Studies, Stroke, Warfarin, Direct-acting oral anticoagulant, Oral anticoagulant, Bleeding, NHLBI Recipient Epidemiology and Donor Evaluation (REDS)-III Study, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundExtrapolation of clinical trial results comparing warfarin and direct-acting oral anticoagulant (DOAC) users experiencing major hemorrhage to clinical care is challenging due to differences seen among non-randomized oral anticoagulant users, bleed location, and etiology. We hypothesized that inpatient all-cause-mortality among patients presenting with major hemorrhage differed based on the home-administered anticoagulant medication class, DOAC versus warfarin.MethodsMore than 1.5 million hospitalizations were screened and 3731 patients with major hemorrhage were identified in the REDS-III Recipient Database. Propensity score matching and stratification were used to account for potentially confounding factors.ResultsInpatient all-cause-mortality was lower for DOAC (HR = 0.60, 95%CI 0.45-0.80, p = 0.0005) before accounting for confounding and competing events. Inpatient all-cause-mortality for 1266 propensity-score-matched patients compared using proportional hazards regression did not differ (HR = 0.84, 95%CI 0.58-1.22, p = 0.36). Inpatient all-cause-mortality in stratified analyses (warfarin as reference) produced: HR = 0.69 (95%CI 0.31-1.55) for traumatic head injuries; HR = 1.10 (95%CI 0.62-1.95) for non-traumatic head injuries; HR = 0.62 (95%CI 0.20-1.94) for traumatic, non-head injuries; and HR = 0.69 (95%CI 0.29-1.63) for non-traumatic, non-head injuries. Mean time to discharge was shorter for DOAC (HR = 1.17, 95%CI 1.05-1.30, p = 0.0034) in the propensity score matched analysis. Plasma transfusion occurred in 42% of warfarin hospitalizations and 11% of DOAC hospitalizations. Vitamin K was administered in 63% of warfarin hospitalizations.ConclusionsAfter accounting for differences in patient characteristics, location of bleed, and traumatic injury, inpatient survival was no different in patients presenting with major hemorrhage while on DOAC or warfarin.

Published
2020

12. High-performance electroadhesive clutches with multilayered architecture.

Author

Aksoy, Bekir, Tan, Sylvia, Peshkin, Michael A., and Colgate, J. Edward

Abstract

Electroadhesive (EA) clutches are promising for advanced motion and force control in robotics, haptics, and rehabilitation, owing to their compactness and light weight. However, their practical use is limited by the inability to deliver high forces at low voltages, primarily due to a lack of understanding of their mechanics. We introduce a novel deformable body fracture mechanics approach and high-resolution strain field imaging to reveal that nonuniform stress distributions cause EA clutches to fail through delamination and crack propagation. Using this insight, we developed EA clutches sustaining 22 newtons over 1 square centimeter at 100 volts, achieving the highest stress per voltage among similar clutches. This was achieved by incorporating a soft interlayer and peeling stopper for uniform stress distribution and mitigating the failure modes. These EA clutches were integrated into a lightweight ring-based wearable system for finger rehabilitation and haptics. Our findings lay the groundwork for designing low-voltage, high-performance EA clutches for next-generation motion and force control applications. [ABSTRACT FROM AUTHOR]

Published
2025
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16. Association of Maternal Pre-Pregnancy or First Trimester Body Mass Index with Neurodevelopmental Outcome in Extremely Low Gestational Age Neonates

Author

Chawla, Sanjay, primary, Laptook, Abbot, additional, Smith, Emily, additional, Tan, Sylvia, additional, Natarajan, Girija, additional, Wyckoff, Myra, additional, Greenberg, Rachel, additional, Ambalavanan, Namasivayam, additional, Bell, Edward, additional, Meurs, Krisa Van, additional, Hintz, Susan, additional, and Vohr, Betty, additional

Published
2023
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18. Community selected strategies to reduce opioid-related overdose deaths in the HEALing (Helping to End Addiction Long-term SM) communities study

Author

Chandler, Redonna, primary, Nunes, Edward V., additional, Tan, Sylvia, additional, Freeman, Patricia R., additional, Walley, Alexander Y., additional, Lofwall, Michelle, additional, Oga, Emmanuel, additional, Glasgow, LaShawn, additional, Brown, Jennifer L., additional, Fanucchi, Laura, additional, Beers, Donna, additional, Hunt, Timothy, additional, Bowers-Sword, Rachel, additional, Roeber, Carter, additional, Baker, Trevor, additional, and Winhusen, T.John, additional

Published
2023
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22. Outcomes Following Candiduria in Extremely Low Birth Weight Infants

Author

The NICHD Neonatal Research Network, Wynn, James L., Tan, Sylvia, Gantz, Marie G., Das, Abhik, Goldberg, Ronald N., Adams-Chapman, Ira, Stoll, Barbara J., Shankaran, Seetha, Walsh, Michele C., Auten, Kathy J., Miller, Nancy A., Sánchez, Pablo J., Higgins, Rosemary D., Cotten, C. Michael, Smith, P. Brian, and Benjamin, Daniel K.

Published
2012
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28. A randomized clinical trial of trans-dermal nicotine replacement in pregnant African-American smokers

Author

Mohandes, Ayman A.E. El-, Windsor, Richard, Tan, Sylvia, Perry, David C., Gantz, Marie G., and Kiely, Michele

Subjects
Usage, Health aspects, Nicotine patches -- Usage -- Health aspects, Smoking in pregnancy, African American women -- Health aspects
Abstract

Introduction Despite the large body of evidence about the adverse impact of smoking on maternal and infant health and available effective treatments [1-3], between 9 and 13% of women in [...], We compared acceptability, adherence and efficacy of trans-dermal nicotine patches and cognitive behavioral therapy (Group 1) to cognitive behavioral therapy alone (Group 2) in minority pregnant smokers. This is a randomized controlled trial. 52 women were recruited during pregnancy with a mean gestational age 18.5 ± 5.0 weeks and followed through delivery. Randomization was by site and initial cotinine levels. Interventionists and interviewers were blinded to group assignment. Two different nicotine replacement therapy dosing regiments were administered according to the baseline salivary cotinine level. A process evaluation model summarized patient adherence. The main outcome measure was self-report of cessation since last visit, confirmed by exhaled carbon monoxide. Analyses of categorical and continuous measures were conducted as well as linear trend tests of salivary cotinine levels. Women lost to follow-up were considered treatment failures. Participants were on average 27.5 ± 5.4 years old, 81% were single, 69% unemployed and 96% were Medicaid eligible. A process evaluation indicated patients in both groups were adherent to scheduled program procedures through Visit 4, but not for Visits 5 and 6. Confirmed quit rates were: at visit 3, 23 (Group 1) and 0% (Group 2) (p = 0.02); at visits 4 and 5, no difference; at visit 6, 19 (Group 1) and 0% (Group 2) (p = 0.05). Group 1 delivered infants with a mean gestational age of 39.4 weeks versus 38.4 weeks in Group 2 (p = 0.02). 73% (52/71) of the eligible smokers agreed to participate and 65% (17/26) of Group 1 completed the protocol (i.e. attended 6 visits). A comparison of Group 1 and 2 quit rates confirmed a non-significant difference. Keywords Pregnancy * African-Americans * Smoking * Nicotine replacement therapy

Published
2013
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31. Accurate MALDI-TOF/TOF sequencing of one-bead--one-compound peptide libraries with application to the identification of multiligand protein affinity agents using in situ click chemistry screening

Author

Lee, Su Seong, Lim, Jaehong, Tan, Sylvia, Cha, Junhoe, Yeo, Shi Yun, Agnew, Heather D., and Heath, James R.

Subjects
Desorption -- Methods, Ionization -- Methods, Time-of-flight mass spectrometry -- Technology application, Time-of-flight mass spectrometry -- Methods, Peptides -- Chemical properties, Affinity labeling -- Methods, Technology application, Chemistry
Abstract

Combinatorial one-bead-one-compound (OBOC) peptide libraries are widely used for affinity screening, and the sequencing of peptides from hit beads is a key step in the process. For rapid sequencing, CNBr cleavage of the peptides from the beads, followed by de novo sequencing by MALDI-TOF/TOF, is explored. We report on a semiautomated sequencing algorithm and validate it through comparison against Edman degradation sequencing. The initial 44% sequencing success rate of the standard de novo sequencing software was improved to nearly 100%. The sequencing algorithm incorporates existing knowledge of amino acid chemistry and a new strategy for differentiating isobaric amino acids. We tested the algorithm by using MALDI-TOF/TOF to identify a peptide biligand affinity agent against the protein bovine carbonic anhydrase H, starting from comprehensive one-bead-one-compound peptide libraries comprised of nonnatural and artificial amino acid components and using the strategy of in sire click/OBOC library screening. 10.1021/ac902195y

Published
2010

32. The Modern Nonya Table

Author

Tan, Sylvia, Tan, Sylvia, Tan, Sylvia, and Tan, Sylvia

Abstract

Sylvia Tan’s The Modern Nonya Table is a compendium of her beloved Peranakan recipes for the modern kitchen. Herself a modern Nonya, Sylvia draws from family heritage recipes and updates them, dispensing with tedious techniques but never compromising on the flavours. She helps readers navigate their way through the Peranakan kitchen, explaining the food culture of the Peranakans (or Straits Chinese) and its influences. Spice pastes, so essential to Peranakan cooking, are broken down into their fundamental elements. With Sylvia’s guide, mouthwatering favourites like ayam buah keluak, babi pongteh and laksa lemak, to lesser-known dishes such as loh kai yik, charbeck and hati babi bungkus, can be easily prepared by the modern home cook.

Published
2019

37. Higher or Lower Hemoglobin Transfusion Thresholds for Preterm Infants

Author

Kirpalani, Haresh, primary, Bell, Edward F., additional, Hintz, Susan R., additional, Tan, Sylvia, additional, Schmidt, Barbara, additional, Chaudhary, Aasma S., additional, Johnson, Karen J., additional, Crawford, Margaret M., additional, Newman, Jamie E., additional, Vohr, Betty R., additional, Carlo, Waldemar A., additional, D’Angio, Carl T., additional, Kennedy, Kathleen A., additional, Ohls, Robin K., additional, Poindexter, Brenda B., additional, Schibler, Kurt, additional, Whyte, Robin K., additional, Widness, John A., additional, Zupancic, John A.F., additional, Wyckoff, Myra H., additional, Truog, William E., additional, Walsh, Michele C., additional, Chock, Valerie Y., additional, Laptook, Abbot R., additional, Sokol, Gregory M., additional, Yoder, Bradley A., additional, Patel, Ravi M., additional, Cotten, C. Michael, additional, Carmen, Melissa F., additional, Devaskar, Uday, additional, Chawla, Sanjay, additional, Seabrook, Ruth, additional, Higgins, Rosemary D., additional, and Das, Abhik, additional

Published
2020
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46. The best of LA 101: strike up the band and let the festivities begin

Author

Arnovitz, Kevin, Davidow, Audrey, Dougherty, Margot, Ebner, Mark, Gardetta, Dave, Handel, Nelson, Heimann, Jim, Inouye, Amy, Ito, Robert, Katz, Jesse, Leibowitz, Ed, Marlis, Beth, Melton, Mary, Mercado, Eric, Mozena, Karl, Nichols, Chris, Nunn, Jennie, Ridenour, Al, Rodman, Howard A., Segal, Matthew, Smith, RJ, Swartley, Ariel, Tan, Sylvia, Tompkins, Joshua, Vontz, Andrew, and Wallace, Amy

Subjects
Los Angeles, California -- Social aspects
Abstract

THIS LIST COULD HAVE clocked in at 1,001, and we would have barely scratched the surface. We love living in Los Angeles, and here are 100 reasons--in no particular order--why […]

Published
2002

47. Association Between Increased Seizures During Rewarming After Hypothermia for Neonatal Hypoxic Ischemic Encephalopathy and Abnormal Neurodevelopmental Outcomes at 2-Year Follow-up: A Nested Multisite Cohort Study.

Author

Chalak, Lina F., Pappas, Athina, Tan, Sylvia, Das, Abhik, Sánchez, Pablo J., Laptook, Abbot R., Van Meurs, Krisa P., Shankaran, Seetha, Bell, Edward F., Davis, Alexis S., Heyne, Roy J., Pedroza, Claudia, Poindexter, Brenda B., Schibler, Kurt, Tyson, Jon E., Ball, M. Bethany, Bara, Rebecca, Grisby, Cathy, Sokol, Gregory M., and D'Angio, Carl T.

Published
2021
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50. Equivalent inpatient mortality among direct-acting oral anticoagulant and warfarin users presenting with major hemorrhage

Author

Bialkowski, Walter, primary, Tan, Sylvia, additional, Mast, Alan E., additional, Kiss, Joseph E., additional, Kor, Daryl, additional, Gottschall, Jerome, additional, Wu, Yanyun, additional, Roubinian, Nareg, additional, Triulzi, Darrell, additional, Kleinman, Steve, additional, Choi, Young, additional, Brambilla, Donald, additional, and Zimrin, Ann, additional

Published
2020
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