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The traveling salesman problem (TSP) is a combinatorial optimization problem that requires finding the shortest path through a set of points ("cities") that returns to the starting point. Because humans provide heuristic near-optimal solutions to Euclidean versions of the problem, it has sometimes been used to investigate human visual problem solving ability. The TSP is also similar to a number of tasks commonly used for neuropsychological assessment (such as the trail-making test), and so its utility in assessing reliable individual differences in problem solving has sometimes been examined. Nevertheless, the task has seen little widespread use in clinical and assessment domains, in part because no standard software implementation or item set is widely available with known psychometric properties. In this paper, we describe a computerized version of TSP running in the free and open source Psychology Experiment Building Language (PEBL). The PEBL TSP task is designed to be suitable for use within a larger battery of tests, and to examine both standard and custom TSP node configurations (i.e., problems). We report the results of a series of experiments that help establish the test's reliability and validity. The first experiment examines test-retest reliability, establishes that the quality of solutions in the TSP are not impacted by mild physiological strain, and demonstrates how solution quality obtained by individuals in a physical version is highly correlated with solution quality obtained in the PEBL version. The second experiment evaluates a larger set of problems, and uses the data to identify a small subset of tests that have maximal coherence. A third experiment examines test-retest reliability of this smaller set that can be administered in about five minutes, and establishes that these problems produce composite scores with moderately high (R = 0.75) test-retest reliability, making it suitable for use in many assessment situations, including evaluations of individual differences, personality, and intelligence testing.

• A psychiatric prodrome in MS is increasingly recognised but under characterised. • It is unknown if a psychiatric prodrome is present in AQP4-antibody NMOSD and MOGAD. • The frequency of psychiatric morbidity before neurological diagnosis was higher in MS compared to AQP4-Ab NMOSD and MOGAD. • An increased frequency of psychiatric comorbidity was seen in AQP4-Ab NMOSD after neurological diagnosis. • Psychiatric burden was low in MOGAD, both in the pre- and post-diagnostic period. Psychiatric comorbidities are common in Multiple Sclerosis (MS) and are increasingly recognised in Aquaporin-4-Antibody Neuromyelitis Optica Spectrum Disorders (AQP4-Ab NMOSD) and Myelin Oligodendrocyte Glycoprotein-Antibody Associated Disease (MOGAD). However, it is unclear if these psychiatric comorbidities predate neurological diagnosis or classical neurological symptoms that are conventionally used to establish the onset of these central nervous system inflammatory demyelinating diseases. We sought to: (1) assess the frequency and incidence of psychiatrist-diagnosed psychiatric disorders before and after formal MS, AQP4-Ab NMOSD, and MOGAD diagnosis, and (2) identify potential factors associated with the presence of pre-existing psychiatric morbidity and depression severity at the first clinical visit for MS patients. A retrospective observational study was performed on MS, AQP4-Ab NMOSD, and MOGAD patients seen at the National Neuroscience Institute (NNI) Singapore. Individuals with psychiatrist-diagnosed psychiatric disorders before and after neurological diagnosis were identified. Demographic, clinical data, and Patient Health Questionnaire (PHQ)-9 score at first clinic visit were collected and analysed. Three hundred and ninety-nine patients (249 MS, 102 AQP4-Ab NMOSD, 48 MOGAD) were included. A higher proportion of MS patients (13/249, 5.2%) had psychiatric disorders before neurological diagnosis, compared to AQP4-Ab NMOSD (1/102, 1.0%) and MOGAD (0/48, 0.0%) (p = 0.054). Within MS patients, univariate logistic regression revealed that age, sex, race, MS subtype, initial MRI lesion load, and interval between classical MS symptom onset to MS diagnosis were not associated with pre-existing psychiatric disorders. Mean PHQ-9 score for MS patients at their first MS consult was 4.4 (cut-off for no/minimal depression is ≤4); no clinical factors were predictive of higher PHQ-9 scores on univariate linear regression. The proportion of MS patients (29/236, 12.2%) who developed psychiatric illness after neurological diagnosis was not different from AQP4-Ab NMOSD (9/101, 8.9%) (p > 0.999), while this was significantly higher compared to MOGAD (0/48, 0.0%) (p = 0.021). The incidence rate of psychiatric diseases after neurological diagnosis, accounting for follow up time, was also similar between MS and AQP4-Ab NMOSD (incidence rate ratio 1.2; 95% confidence interval 0.54 – 2.8; p = 0.689). There is a significant psychiatric burden prior to MS diagnosis compared to AQP4-Ab NMOSD and MOGAD. The increased frequency of psychiatric comorbidity after NMOSD diagnosis merits further study to investigate the determinants of this phenomenon. [ABSTRACT FROM AUTHOR]

Advertisement denotes a standard strategy of attracting public interest and facilitating purchase decisions. This research aims to determine the digital advertisement feature effects on consumer purchase intent in Malaysia. A cross-sectional design was employed to gather quantitative data from 361 Malaysian respondents with a digital survey. Additionally, SPSS was utilised to assess the digital advertising-purchase intention relationship. Resultantly, pictorial cues, repetition, and sensory stores significantly influenced Malaysian consumers' purchase intention. Following the motivation theory, this research identified a relationship between digital advertising feature effects and purchase intention power that proved inadequate in past studies. The study outcome proved vital in rearranging advertising methods to be more appealing and informative for customers to receive clear and precise knowledge. [ABSTRACT FROM AUTHOR]