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1. Demographic, clinical, and service-use characteristics related to the clinician’s recommendation to transition from child to adult mental health services

Author

Gerritsen, S. E., van Bodegom, L. S., Dieleman, G. C., Overbeek, M. M., Verhulst, F. C., Wolke, D., Rizopoulos, D., Appleton, R., van Amelsvoort, T. A. M. J., Bodier Rethore, C., Bonnet-Brilhault, F., Charvin, I., Da Fonseca, D., Davidović, N., Dodig-Ćurković, K., Ferrari, A., Fiori, F., Franić, T., Gatherer, C., de Girolamo, G., Heaney, N., Hendrickx, G., Jardri, R., Kolozsvari, A., Lida-Pulik, H., Lievesley, K., Madan, J., Mastroianni, M., Maurice, V., McNicholas, F., Nacinovich, R., Parenti, A., Paul, M., Purper-Ouakil, D., Rivolta, L., de Roeck, V., Russet, F., Saam, M. C., Sagar-Ouriaghli, I., Santosh, P. J., Sartor, A., Schulze, U. M. E., Scocco, P., Signorini, G., Singh, S. P., Singh, J., Speranza, M., Stagi, P., Stagni, P., Street, C., Tah, P., Tanase, E., Tremmery, S., Tuffrey, A., Tuomainen, H., Walker, L., Wilson, A., and Maras, A.

Published
2022
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2. Demographic, clinical, and service-use characteristics related to the clinician’s recommendation to transition from child to adult mental health services

Author

Gerritsen, S, van Bodegom, L, Dieleman, G, Overbeek, M, Verhulst, F, Wolke, D, Rizopoulos, D, Appleton, R, van Amelsvoort, T, Bodier Rethore, C, Bonnet-Brilhault, F, Charvin, I, Da Fonseca, D, Davidovic, N, Dodig-Curkovic, K, Ferrari, A, Fiori, F, Franic, T, Gatherer, C, de Girolamo, G, Heaney, N, Hendrickx, G, Jardri, R, Kolozsvari, A, Lida-Pulik, H, Lievesley, K, Madan, J, Mastroianni, M, Maurice, V, Mcnicholas, F, Nacinovich, R, Parenti, A, Paul, M, Purper-Ouakil, D, Rivolta, L, de Roeck, V, Russet, F, Saam, M, Sagar-Ouriaghli, I, Santosh, P, Sartor, A, Schulze, U, Scocco, P, Signorini, G, Singh, S, Singh, J, Speranza, M, Stagi, P, Stagni, P, Street, C, Tah, P, Tanase, E, Tremmery, S, Tuffrey, A, Tuomainen, H, Walker, L, Wilson, A, Maras, A, Adams, L, Allibrio, G, Armando, M, Aslan, S, Baccanelli, N, Balaudo, M, Bergamo, F, Bertani, A, Berriman, J, Boon, A, Braamse, K, Breuninger, U, Buttiglione, M, Buttle, S, Schandrin, A, Cammarano, M, Canaway, A, Cantini, F, Cappellari, C, Carenini, M, Carra, G, Ferrari, C, Chianura, K, Coleman, P, Colonna, A, Conese, P, Costanzo, R, Daffern, C, Danckaerts, M, de Giacomo, A, Ermans, J, Farmer, A, Fegert, J, Ferrari, S, Galea, G, Gatta, M, Gheza, E, Goglia, G, Grandetto, M, Griffin, J, Levi, F, Humbertclaude, V, Ingravallo, N, Invernizzi, R, Kelly, C, Killilea, M, Kirwan, J, Klockaerts, C, Kovac, V, Liew, A, Lippens, C, Macchi, F, Manenti, L, Margari, F, Margari, L, Martinelli, P, Mcfadden, L, Menghini, D, Miller, S, Monzani, E, Morini, G, Mutafov, T, O'Hara, L, Negrinotti, C, Nelis, E, Neri, F, Nikolova, P, Nossa, M, Cataldo, M, Noterdaeme, M, Operto, F, Panaro, V, Pastore, A, Pemmaraju, V, Pepermans, A, Petruzzelli, M, Presicci, A, Prigent, C, Rinaldi, F, Riva, E, Roekens, A, Rogers, B, Ronzini, P, Sakar, V, Salvetti, S, Martinelli, O, Sandhu, T, Schepker, R, Siviero, M, Slowik, M, Smyth, C, Conti, P, Spadone, M, Starace, F, Stoppa, P, Tansini, L, Toselli, C, Trabucchi, G, Tubito, M, van Dam, A, van Gutschoven, H, van West, D, Vanni, F, Vannicola, C, Varuzza, C, Varvara, P, Ventura, P, Vicari, S, Vicini, S, von Bentzel, C, Wells, P, Williams, B, Zabarella, M, Zamboni, A, Zanetti, E, Gerritsen S. E., van Bodegom L. S., Dieleman G. C., Overbeek M. M., Verhulst F. C., Wolke D., Rizopoulos D., Appleton R., van Amelsvoort T. A. M. J., Bodier Rethore C., Bonnet-Brilhault F., Charvin I., Da Fonseca D., Davidovic N., Dodig-Curkovic K., Ferrari A., Fiori F., Franic T., Gatherer C., de Girolamo G., Heaney N., Hendrickx G., Jardri R., Kolozsvari A., Lida-Pulik H., Lievesley K., Madan J., Mastroianni M., Maurice V., McNicholas F., Nacinovich R., Parenti A., Paul M., Purper-Ouakil D., Rivolta L., de Roeck V., Russet F., Saam M. C., Sagar-Ouriaghli I., Santosh P. J., Sartor A., Schulze U. M. E., Scocco P., Signorini G., Singh S. P., Singh J., Speranza M., Stagi P., Stagni P., Street C., Tah P., Tanase E., Tremmery S., Tuffrey A., Tuomainen H., Walker L., Wilson A., Maras A., Adams L., Allibrio G., Armando M., Aslan S., Baccanelli N., Balaudo M., Bergamo F., Bertani A., Berriman J., Boon A., Braamse K., Breuninger U., Buttiglione M., Buttle S., Schandrin A., Cammarano M., Canaway A., Cantini F., Cappellari C., Carenini M., Carra G., Ferrari C., Chianura K., Coleman P., Colonna A., Conese P., Costanzo R., Daffern C., Danckaerts M., de Giacomo A., Ermans J. -P., Farmer A., Fegert J. M., Ferrari S., Galea G., Gatta M., Gheza E., Goglia G., Grandetto M. R., Griffin J., Levi F. M., Humbertclaude V., Ingravallo N., Invernizzi R., Kelly C., Killilea M., Kirwan J., Klockaerts C., Kovac V., Liew A., Lippens C., Macchi F., Manenti L., Margari F., Margari L., Martinelli P., McFadden L., Menghini D., Miller S., Monzani E., Morini G., Mutafov T., O'Hara L., Negrinotti C., Nelis E., Neri F., Nikolova P., Nossa M., Cataldo M. G., Noterdaeme M., Operto F., Panaro V., Pastore A., Pemmaraju V., Pepermans A., Petruzzelli M. G., Presicci A., Prigent C., Rinaldi F., Riva E., Roekens A., Rogers B., Ronzini P., Sakar V., Salvetti S., Martinelli O., Sandhu T., Schepker R., Siviero M., Slowik M., Smyth C., Conti P., Spadone M. A., Starace F., Stoppa P., Tansini L., Toselli C., Trabucchi G., Tubito M., van Dam A., van Gutschoven H., van West D., Vanni F., Vannicola C., Varuzza C., Varvara P., Ventura P., Vicari S., Vicini S., von Bentzel C., Wells P., Williams B., Zabarella M., Zamboni A., Zanetti E., Gerritsen, S, van Bodegom, L, Dieleman, G, Overbeek, M, Verhulst, F, Wolke, D, Rizopoulos, D, Appleton, R, van Amelsvoort, T, Bodier Rethore, C, Bonnet-Brilhault, F, Charvin, I, Da Fonseca, D, Davidovic, N, Dodig-Curkovic, K, Ferrari, A, Fiori, F, Franic, T, Gatherer, C, de Girolamo, G, Heaney, N, Hendrickx, G, Jardri, R, Kolozsvari, A, Lida-Pulik, H, Lievesley, K, Madan, J, Mastroianni, M, Maurice, V, Mcnicholas, F, Nacinovich, R, Parenti, A, Paul, M, Purper-Ouakil, D, Rivolta, L, de Roeck, V, Russet, F, Saam, M, Sagar-Ouriaghli, I, Santosh, P, Sartor, A, Schulze, U, Scocco, P, Signorini, G, Singh, S, Singh, J, Speranza, M, Stagi, P, Stagni, P, Street, C, Tah, P, Tanase, E, Tremmery, S, Tuffrey, A, Tuomainen, H, Walker, L, Wilson, A, Maras, A, Adams, L, Allibrio, G, Armando, M, Aslan, S, Baccanelli, N, Balaudo, M, Bergamo, F, Bertani, A, Berriman, J, Boon, A, Braamse, K, Breuninger, U, Buttiglione, M, Buttle, S, Schandrin, A, Cammarano, M, Canaway, A, Cantini, F, Cappellari, C, Carenini, M, Carra, G, Ferrari, C, Chianura, K, Coleman, P, Colonna, A, Conese, P, Costanzo, R, Daffern, C, Danckaerts, M, de Giacomo, A, Ermans, J, Farmer, A, Fegert, J, Ferrari, S, Galea, G, Gatta, M, Gheza, E, Goglia, G, Grandetto, M, Griffin, J, Levi, F, Humbertclaude, V, Ingravallo, N, Invernizzi, R, Kelly, C, Killilea, M, Kirwan, J, Klockaerts, C, Kovac, V, Liew, A, Lippens, C, Macchi, F, Manenti, L, Margari, F, Margari, L, Martinelli, P, Mcfadden, L, Menghini, D, Miller, S, Monzani, E, Morini, G, Mutafov, T, O'Hara, L, Negrinotti, C, Nelis, E, Neri, F, Nikolova, P, Nossa, M, Cataldo, M, Noterdaeme, M, Operto, F, Panaro, V, Pastore, A, Pemmaraju, V, Pepermans, A, Petruzzelli, M, Presicci, A, Prigent, C, Rinaldi, F, Riva, E, Roekens, A, Rogers, B, Ronzini, P, Sakar, V, Salvetti, S, Martinelli, O, Sandhu, T, Schepker, R, Siviero, M, Slowik, M, Smyth, C, Conti, P, Spadone, M, Starace, F, Stoppa, P, Tansini, L, Toselli, C, Trabucchi, G, Tubito, M, van Dam, A, van Gutschoven, H, van West, D, Vanni, F, Vannicola, C, Varuzza, C, Varvara, P, Ventura, P, Vicari, S, Vicini, S, von Bentzel, C, Wells, P, Williams, B, Zabarella, M, Zamboni, A, Zanetti, E, Gerritsen S. E., van Bodegom L. S., Dieleman G. C., Overbeek M. M., Verhulst F. C., Wolke D., Rizopoulos D., Appleton R., van Amelsvoort T. A. M. J., Bodier Rethore C., Bonnet-Brilhault F., Charvin I., Da Fonseca D., Davidovic N., Dodig-Curkovic K., Ferrari A., Fiori F., Franic T., Gatherer C., de Girolamo G., Heaney N., Hendrickx G., Jardri R., Kolozsvari A., Lida-Pulik H., Lievesley K., Madan J., Mastroianni M., Maurice V., McNicholas F., Nacinovich R., Parenti A., Paul M., Purper-Ouakil D., Rivolta L., de Roeck V., Russet F., Saam M. C., Sagar-Ouriaghli I., Santosh P. J., Sartor A., Schulze U. M. E., Scocco P., Signorini G., Singh S. P., Singh J., Speranza M., Stagi P., Stagni P., Street C., Tah P., Tanase E., Tremmery S., Tuffrey A., Tuomainen H., Walker L., Wilson A., Maras A., Adams L., Allibrio G., Armando M., Aslan S., Baccanelli N., Balaudo M., Bergamo F., Bertani A., Berriman J., Boon A., Braamse K., Breuninger U., Buttiglione M., Buttle S., Schandrin A., Cammarano M., Canaway A., Cantini F., Cappellari C., Carenini M., Carra G., Ferrari C., Chianura K., Coleman P., Colonna A., Conese P., Costanzo R., Daffern C., Danckaerts M., de Giacomo A., Ermans J. -P., Farmer A., Fegert J. M., Ferrari S., Galea G., Gatta M., Gheza E., Goglia G., Grandetto M. R., Griffin J., Levi F. M., Humbertclaude V., Ingravallo N., Invernizzi R., Kelly C., Killilea M., Kirwan J., Klockaerts C., Kovac V., Liew A., Lippens C., Macchi F., Manenti L., Margari F., Margari L., Martinelli P., McFadden L., Menghini D., Miller S., Monzani E., Morini G., Mutafov T., O'Hara L., Negrinotti C., Nelis E., Neri F., Nikolova P., Nossa M., Cataldo M. G., Noterdaeme M., Operto F., Panaro V., Pastore A., Pemmaraju V., Pepermans A., Petruzzelli M. G., Presicci A., Prigent C., Rinaldi F., Riva E., Roekens A., Rogers B., Ronzini P., Sakar V., Salvetti S., Martinelli O., Sandhu T., Schepker R., Siviero M., Slowik M., Smyth C., Conti P., Spadone M. A., Starace F., Stoppa P., Tansini L., Toselli C., Trabucchi G., Tubito M., van Dam A., van Gutschoven H., van West D., Vanni F., Vannicola C., Varuzza C., Varvara P., Ventura P., Vicari S., Vicini S., von Bentzel C., Wells P., Williams B., Zabarella M., Zamboni A., and Zanetti E.

Abstract

Purpose: The service configuration with distinct child and adolescent mental health services (CAMHS) and adult mental health services (AMHS) may be a barrier to continuity of care. Because of a lack of transition policy, CAMHS clinicians have to decide whether and when a young person should transition to AMHS. This study describes which characteristics are associated with the clinicians’ advice to continue treatment at AMHS. Methods: Demographic, family, clinical, treatment, and service-use characteristics of the MILESTONE cohort of 763 young people from 39 CAMHS in Europe were assessed using multi-informant and standardized assessment tools. Logistic mixed models were fitted to assess the relationship between these characteristics and clinicians’ transition recommendations. Results: Young people with higher clinician-rated severity of psychopathology scores, with self- and parent-reported need for ongoing treatment, with lower everyday functional skills and without self-reported psychotic experiences were more likely to be recommended to continue treatment. Among those who had been recommended to continue treatment, young people who used psychotropic medication, who had been in CAMHS for more than a year, and for whom appropriate AMHS were available were more likely to be recommended to continue treatment at AMHS. Young people whose parents indicated a need for ongoing treatment were more likely to be recommended to stay in CAMHS. Conclusion: Although the decision regarding continuity of treatment was mostly determined by a small set of clinical characteristics, the recommendation to continue treatment at AMHS was mostly affected by service-use related characteristics, such as the availability of appropriate services.

Published
2022

3. The importance of clinicians' and parents' awareness of suicidal behaviour in adolescents reaching the upper age limit of their mental health services in Europe

Author

van Bodegom, L, Gerritsen, S, Dieleman, G, Overbeek, M, de Girolamo, G, Scocco, P, Hillegers, M, Wolke, D, Rizopoulos, D, Appleton, R, Conti, P, Franić, T, Margari, F, Madan, J, Mcnicholas, F, Nacinovich, R, Pastore, A, Paul, M, Purper-Ouakil, D, Saam, M, Santosh, P, Sartor, A, Schulze, U, Signorini, G, Singh, S, Street, C, Tah, P, Tanase, E, Tremmery, S, Tuomainen, H, Maras, A, van Bodegom, Larissa S, Gerritsen, Suzanne E, Dieleman, Gwendolyn C, Overbeek, Mathilde M, de Girolamo, Giovanni, Scocco, Paolo, Hillegers, Manon H J, Wolke, Dieter, Rizopoulos, Dimitris, Appleton, Rebecca, Conti, Patrizia, Franić, Tomislav, Margari, Francesco, Madan, Jason, McNicholas, Fiona, Nacinovich, Renata, Pastore, Adriana, Paul, Moli, Purper-Ouakil, Diane, Saam, Melanie C, Santosh, Paramala J, Sartor, Anne, Schulze, Ulrike M E, Signorini, Giulia, Singh, Swaran P, Street, Cathy, Tah, Priya, Tanase, Elena, Tremmery, Sabine, Tuomainen, Helena, Maras, Athanasios, van Bodegom, L, Gerritsen, S, Dieleman, G, Overbeek, M, de Girolamo, G, Scocco, P, Hillegers, M, Wolke, D, Rizopoulos, D, Appleton, R, Conti, P, Franić, T, Margari, F, Madan, J, Mcnicholas, F, Nacinovich, R, Pastore, A, Paul, M, Purper-Ouakil, D, Saam, M, Santosh, P, Sartor, A, Schulze, U, Signorini, G, Singh, S, Street, C, Tah, P, Tanase, E, Tremmery, S, Tuomainen, H, Maras, A, van Bodegom, Larissa S, Gerritsen, Suzanne E, Dieleman, Gwendolyn C, Overbeek, Mathilde M, de Girolamo, Giovanni, Scocco, Paolo, Hillegers, Manon H J, Wolke, Dieter, Rizopoulos, Dimitris, Appleton, Rebecca, Conti, Patrizia, Franić, Tomislav, Margari, Francesco, Madan, Jason, McNicholas, Fiona, Nacinovich, Renata, Pastore, Adriana, Paul, Moli, Purper-Ouakil, Diane, Saam, Melanie C, Santosh, Paramala J, Sartor, Anne, Schulze, Ulrike M E, Signorini, Giulia, Singh, Swaran P, Street, Cathy, Tah, Priya, Tanase, Elena, Tremmery, Sabine, Tuomainen, Helena, and Maras, Athanasios

Abstract

Background: To study clinicians' and parents' awareness of suicidal behaviour in adolescents reaching the upper age limit of their Child and Adolescent Mental Health Service (CAMHS) and its association with mental health indicators, transition recommendations and mental health service (MHS) use. Methods: 763 CAMHS users from eight European countries were assessed using multi-informant and standardised assessment tools at baseline and nine months follow-up. Separate ANCOVA's and pairwise comparisons were conducted to assess whether clinicians' and parents' awareness of young people's suicidal behaviour were associated with mental health indicators, clinician's recommendations to continue treatment and MHS use at nine months follow-up. Results: 53.5 % of clinicians and 56.9 % of parents were unaware of young people's self-reported suicidal behaviour at baseline. Compared to those whose clinicians/parents were aware, unawareness was associated with a 72–80 % lower proportion of being recommended to continue treatment. Self-reported mental health problems at baseline were comparable for young people whose clinicians and parents were aware and unaware of suicidal behaviour. Clinicians' and parents' unawareness were not associated with MHS use at follow-up. Limitations: Aspects of suicidal behaviour, such as suicide ideation, -plans and -attempts, could not be distinguished. Few young people transitioned to Adult Mental Health Services (AMHS), therefore power to study factors associated with AMHS use was limited. Conclusion: Clinicians and parents are often unaware of suicidal behaviour, which decreases the likelihood of a recommendation to continue treatment, but does not seem to affect young people's MHS use or their mental health problems.

Published
2023

4. Dietary Patterns and Mortality in a Multinational Cohort of Adults Receiving Hemodialysis

Author

Saglimbene, Valeria M., primary, Wong, Germaine, additional, Teixeira-Pinto, Armando, additional, Ruospo, Marinella, additional, Garcia-Larsen, Vanessa, additional, Palmer, Suetonia C., additional, Natale, Patrizia, additional, Campbell, Katrina, additional, Carrero, Juan-Jesus, additional, Stenvinkel, Peter, additional, Gargano, Letizia, additional, Murgo, Angelo M., additional, Johnson, David W., additional, Tonelli, Marcello, additional, Gelfman, Rubén, additional, Celia, Eduardo, additional, Ecder, Tevfik, additional, Bernat, Amparo G., additional, Del Castillo, Domingo, additional, Timofte, Delia, additional, Török, Marietta, additional, Bednarek-Skublewska, Anna, additional, Duława, Jan, additional, Stroumza, Paul, additional, Hansis, Martin, additional, Fabricius, Elisabeth, additional, Felaco, Paolo, additional, Wollheim, Charlotta, additional, Hegbrant, Jörgen, additional, Craig, Jonathan C., additional, Strippoli, Giovanni F.M., additional, Badino, A., additional, Petracci, L., additional, Villareal, C., additional, Soto, M., additional, Arias, M., additional, Vera, F., additional, Quispe, V., additional, Morales, S., additional, Bueno, D., additional, Bargna, R., additional, Peñaloza, G., additional, Alcalde, L., additional, Dayer, J., additional, Milán, A., additional, Centurión, N., additional, Ramos, A., additional, De Orta, E., additional, Menardi, S., additional, Austa Bel, N., additional, Marileo, E., additional, Junqueras, N., additional, Favalli, C., additional, Trioni, R., additional, Valle, G., additional, López, M., additional, Marinaro, C., additional, Fernandez, A., additional, Corral, J., additional, Nattiello, E., additional, Marone, S., additional, García, J., additional, Carrizo, G., additional, González, P., additional, Delicia, O., additional, Maza, M., additional, Chauque, M., additional, Mora, J., additional, Grbavac, D., additional, López, L., additional, Alonso, M., additional, Villalba, C., additional, Simon, M., additional, Cernadas, M., additional, Moscatelli, C., additional, Vilamajó, I., additional, Tursky, C., additional, Martínez, M., additional, Villalba, F., additional, Pereira, D., additional, Araujo, S., additional, López, H., additional, Alonso, V., additional, Vázquez, B., additional, Rapetti, M., additional, Raña, S., additional, Capdevila, M., additional, Ljubich, C., additional, Acosta, M., additional, Coombes, M., additional, Doria, V., additional, Ávila, M., additional, Cáceres, D., additional, Geandet, E., additional, Romero, C., additional, Morales, E., additional, Recalde, C., additional, Casanú, M., additional, Lococo, B., additional, Da Cruz, O., additional, Focsaner, C., additional, Galarce, D., additional, Albarracín, L., additional, Vescovo, E., additional, Gravielle, M., additional, Florio, D., additional, Baumgart, L., additional, Corbalán, M., additional, Aguilera, V., additional, Hermida, O., additional, Galli, C., additional, Ziombra, L., additional, Gutierrez, A., additional, Frydelund, S., additional, Hardaman, A., additional, Maciel, A., additional, Arrigo, M., additional, Mato Mira, C., additional, Leibovich, J., additional, Paparone, R., additional, Muller, E., additional, Malimar, A., additional, Leocadio, I., additional, Cruz, W., additional, Tirado, S., additional, Peñalba, A., additional, Cejas, R., additional, Mansilla, S., additional, Campos, C., additional, Abrego, E., additional, Chávez, P., additional, Corpacci, G., additional, Echavarría, A., additional, Engler, C., additional, Vergara, P., additional, Hubeli, M., additional, Redondo, G., additional, Noroña, B., additional, Boriceanu, C., additional, Lankester, M., additional, Poignet, J.L., additional, Saingra, Y., additional, Indreies, M., additional, Santini, J., additional, Mahi, A., additional, Robert, A., additional, Bouvier, P., additional, Merzouk, T., additional, Villemain, F., additional, Pajot, A., additional, Tollis, F., additional, Brahim-Bounab, M., additional, Benmoussa, A., additional, Albitar, S., additional, Guimont, M.C., additional, Ciobotaru, P., additional, Guerin, A., additional, Diaconita, M., additional, Hoischen, S.H., additional, Saupe, J., additional, Ullmann, I., additional, Grosser, S., additional, Kunow, J., additional, Grueger, S., additional, Bischoff, D., additional, Benders, J., additional, Worch, P., additional, Pfab, T., additional, Kamin, N., additional, Roesch, M., additional, May, M., additional, Albert, K., additional, Csaszar, I., additional, Kiss, E., additional, Kosa, D., additional, Orosz, A., additional, Redl, J., additional, Kovacs, L., additional, Varga, E., additional, Szabo, M., additional, Magyar, K., additional, Zajko, E., additional, Bereczki, A., additional, Csikos, J., additional, Kerekes, E., additional, Mike, A., additional, Steiner, K., additional, Nemeth, E., additional, Tolnai, K., additional, Toth, A., additional, Vinczene, J., additional, Szummer, S.z., additional, Tanyi, E., additional, Szilvia, M., additional, Murgo, A.M., additional, Sanfilippo, N., additional, Dambrosio, N., additional, Saturno, C., additional, Matera, G., additional, Benevento, M., additional, Greco, V., additional, di Leo, G., additional, Papagni, S., additional, Alicino, F., additional, Marangelli, A., additional, Pedone, F., additional, Cagnazzo, A.V., additional, Antinoro, R., additional, Sambati, M.L., additional, Donatelli, C., additional, Ranieri, F., additional, Torsello, F., additional, Steri, P., additional, Riccardi, C., additional, Flammini, A., additional, Moscardelli, L., additional, Boccia, E., additional, Mantuano, M., additional, Di Toro Mammarella, R., additional, Meconizzi, M., additional, Fichera, R., additional, D’Angelo, A., additional, Latassa, G., additional, Molino, A., additional, Fici, M., additional, Lupo, A., additional, Montalto, G., additional, Messina, S., additional, Capostagno, C., additional, Randazzo, G., additional, Pagano, S., additional, Marino, G., additional, Rallo, D., additional, Maniscalco, A., additional, Trovato, O.M., additional, Strano, C., additional, Failla, A., additional, Bua, A., additional, Campo, S., additional, Nasisi, P., additional, Salerno, A., additional, Laudani, S., additional, Grippaldi, F., additional, Bertino, D., additional, Di Benedetto, D.V., additional, Puglisi, A., additional, Chiarenza, S., additional, Lentini Deuscit, M., additional, Incardona, C.M., additional, Scuto, G., additional, Todaro, C., additional, Dino, A., additional, Novello, D., additional, Coco, A., additional, Bocheńska-Nowacka, E., additional, Jaroszyński, A., additional, Drabik, J., additional, Wypych-Birecka, M., additional, Daniewska, D., additional, Drobisz, M., additional, Doskocz, K., additional, Wyrwicz-Zielińska, G., additional, Kosicki, A., additional, Ślizień, W., additional, Rutkowski, P., additional, Arentowicz, S., additional, Dzimira, S., additional, Grabowska, M., additional, Ostrowski, J., additional, Całka, A., additional, Grzegorczyk, T., additional, Dżugan, W., additional, Mazur, M., additional, Myślicki, M., additional, Piechowska, M., additional, Kozicka, D., additional, de Sá Martins, V., additional, Aguiar, L., additional, Mira, A.R., additional, Velez, B., additional, Pinheiro, T., additional, Agapi, E., additional, Ardelean, C.L., additional, Baidog, A., additional, Bako, G., additional, Barb, M., additional, Blaga, A., additional, Bodurian, E., additional, Bumbea, V., additional, Dragan, E., additional, Dumitrache, D., additional, Florescu, L., additional, Havasi, N., additional, Hint, S., additional, Ilies, R., additional, Mandita, A.G.M., additional, Marian, R.I., additional, Medrihan, S.L., additional, Mitea, L., additional, Mitea, S., additional, Mocanu, R., additional, Moro, D.C., additional, Nitu, M., additional, Popa, M.L., additional, Popa, M., additional, Railean, E., additional, Scuturdean, A.R., additional, Szentendrey, K., additional, Teodoru, C.L., additional, Varga, A., additional, García, M., additional, Olaya, M., additional, Abujder, V., additional, Carreras, J., additional, López, A., additional, Ros, F., additional, Cuesta, G., additional, García, A., additional, Orero, E., additional, Ros, E., additional, Bea, S., additional, Pizarro, J.L., additional, Luengo, S., additional, Romero, A., additional, Navarro, M., additional, Cermeño, L., additional, Rodriguez, A., additional, Lopez, D., additional, Barrera, A., additional, Montoya, F., additional, Tajahuerce, J., additional, Carro, M., additional, Cunill, M.Q., additional, Narci, S., additional, Ballester, T., additional, Soler, M.J., additional, Traver, S., additional, Buta, P.P., additional, Cucuiat, L., additional, Rosu, L., additional, Garcia, I., additional, Gavra, C.M., additional, Gonzalez, R., additional, Filimon, S., additional, Peñalver, M., additional, Benages, V., additional, Cardo, M.I., additional, García, E., additional, Soler, P., additional, Fernnandez, E., additional, Popescu, F., additional, Munteanu, R., additional, Tanase, E., additional, Sagau, F., additional, Prades, D., additional, Esteller, S., additional, Gonzalez, E., additional, Martinez, R., additional, Diago, A., additional, Torres, J., additional, Perez, E., additional, Garcia, C., additional, Lluch, I., additional, Forcano, J., additional, Fóns, M., additional, Rodríguez, A., additional, Millán, N.A., additional, Fernández, J., additional, Ferreiro, B., additional, Otero, M., additional, Pesqueira, V., additional, Abal, S., additional, Álvarez, R., additional, Jorge, C., additional, Rico, I., additional, de Dios Ramiro, J., additional, Duzy, L., additional, Soto, A., additional, Lopez, J.L., additional, Diaz, Y., additional, Herrero, I., additional, Farré, M., additional, Blasco, C., additional, Ferrás, S., additional, Agost, M.J., additional, Miracle, C., additional, Farto, J., additional, Goch, J., additional, Katzarski, K.S., additional, Wulcan, A., additional, Akbiber, H., additional, Arslan, H., additional, Bicen, L., additional, Buyukkiraz, A., additional, Celik, R., additional, Dogan, I.S., additional, Erkalkan, S., additional, Ertas, A., additional, Hark, U., additional, Iravul, E., additional, Karakaya, M., additional, Mengu, K., additional, Ongun, S., additional, Ozkan, Z., additional, Ozlu, A., additional, Ozveren, N., additional, Sifil, H.M., additional, Sonmez Turksoz, N., additional, and Yilmaz, Z., additional

Published
2020
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7. The importance of clinicians' and parents' awareness of suicidal behaviour in adolescents reaching the upper age limit of their mental health services in Europe

Author

Larissa S. van Bodegom, Suzanne E. Gerritsen, Gwendolyn C. Dieleman, Mathilde M. Overbeek, Giovanni de Girolamo, Paolo Scocco, Manon H.J. Hillegers, Dieter Wolke, Dimitris Rizopoulos, Rebecca Appleton, Patrizia Conti, Tomislav Franić, Francesco Margari, Jason Madan, Fiona McNicholas, Renata Nacinovich, Adriana Pastore, Moli Paul, Diane Purper-Ouakil, Melanie C. Saam, Paramala J. Santosh, Anne Sartor, Ulrike M.E. Schulze, Giulia Signorini, Swaran P. Singh, Cathy Street, Priya Tah, Elena Tanase, Sabine Tremmery, Helena Tuomainen, Athanasios Maras, Child and Adolescent Psychiatry / Psychology, Epidemiology, van Bodegom, L, Gerritsen, S, Dieleman, G, Overbeek, M, de Girolamo, G, Scocco, P, Hillegers, M, Wolke, D, Rizopoulos, D, Appleton, R, Conti, P, Franić, T, Margari, F, Madan, J, Mcnicholas, F, Nacinovich, R, Pastore, A, Paul, M, Purper-Ouakil, D, Saam, M, Santosh, P, Sartor, A, Schulze, U, Signorini, G, Singh, S, Street, C, Tah, P, Tanase, E, Tremmery, S, Tuomainen, H, Maras, A, Clinical Child and Family Studies, LEARN! - Child rearing, and APH - Mental Health

Subjects
Suicidal thought, Suicidal thoughts, Psychiatry and Mental health, Clinical Psychology, Adolescent, Mental health services, SDG 3 - Good Health and Well-being, MED/39 - NEUROPSICHIATRIA INFANTILE, Mental health service, Transition to adult care
Abstract

Background: To study clinicians' and parents' awareness of suicidal behaviour in adolescents reaching the upper age limit of their Child and Adolescent Mental Health Service (CAMHS) and its association with mental health indicators, transition recommendations and mental health service (MHS) use. Methods: 763 CAMHS users from eight European countries were assessed using multi-informant and standardised assessment tools at baseline and nine months follow-up. Separate ANCOVA's and pairwise comparisons were conducted to assess whether clinicians' and parents' awareness of young people's suicidal behaviour were associated with mental health indicators, clinician's recommendations to continue treatment and MHS use at nine months follow-up. Results: 53.5 % of clinicians and 56.9 % of parents were unaware of young people's self-reported suicidal behaviour at baseline. Compared to those whose clinicians/parents were aware, unawareness was associated with a 72–80 % lower proportion of being recommended to continue treatment. Self-reported mental health problems at baseline were comparable for young people whose clinicians and parents were aware and unaware of suicidal behaviour. Clinicians' and parents' unawareness were not associated with MHS use at follow-up. Limitations: Aspects of suicidal behaviour, such as suicide ideation, -plans and -attempts, could not be distinguished. Few young people transitioned to Adult Mental Health Services (AMHS), therefore power to study factors associated with AMHS use was limited. Conclusion: Clinicians and parents are often unaware of suicidal behaviour, which decreases the likelihood of a recommendation to continue treatment, but does not seem to affect young people's MHS use or their mental health problems.

Published
2023

8. Exploring the Preventive Potential of Vitamin D against Respiratory Infections in Preschool-Age Children: A Cross-Sectional Study.

Author

Sarau OS, Rachabattuni HC, Gadde ST, Daruvuri SP, Marusca LM, Horhat FG, Fildan AP, Tanase E, Prodan-Barbulescu C, and Horhat DI

Subjects
Humans, Child, Preschool, Cross-Sectional Studies, Male, Female, Incidence, Romania epidemiology, Infant, Recurrence, Respiratory Tract Infections prevention & control, Respiratory Tract Infections epidemiology, Vitamin D blood, Vitamin D analogs & derivatives, Vitamin D administration & dosage, Vitamin D Deficiency blood, Vitamin D Deficiency epidemiology, Dietary Supplements
Abstract

Recent studies hypothesized that vitamin D supplementation and subsequent higher 25(OH)D serum levels could protect against respiratory infections in children. This cross-sectional study, conducted from May 2022 to December 2023 in Timisoara, Romania, aimed to evaluate the potential influence of vitamin D supplementation on the incidence of respiratory infections among preschool-age children. This study examined 215 children over 18 months who were split into a group of patients with recurrent respiratory infections ( n = 141) and another group of patients with only one respiratory tract infection in the past 12 months ( n = 74). Patients were evaluated based on their serum vitamin D levels 25(OH)D, demographic characteristics, and health outcomes. The study identified that preschool-age children with recurrent infections had significantly lower mean vitamin D concentrations (24.5 ng/mL) compared to the control group (29.7 ng/mL, p < 0.001). Additionally, a higher proportion of vitamin D deficiency was observed among children with recurrent infections in the past 12 months. Notably, vitamin D supplementation above 600 IU/week significantly reduced the likelihood of respiratory infections, evidenced by an odds ratio of 0.523 ( p < 0.001), indicating that preschool-age children receiving a dose of vitamin D higher than 600 IU/week were about half as likely to experience respiratory infections compared to those who did not. Furthermore, no significant associations were found between sun exposure, daily sunscreen use, and the incidence of respiratory infections. Conclusively, this study underscores the potential role of vitamin D in helping the immune system against respiratory infections in preschool-age children. The observed protective effect of vitamin D supplementation suggests a potential public health strategy to mitigate the incidence of respiratory infections in preschool children on top of the already known benefits.

Published
2024
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9. Kidney Function Tests and Continuous eGFR Decrease at Six Months after SARS-CoV-2 Infection in Patients Clinically Diagnosed with Post-COVID Syndrome.

Author

Boruga M, Septimiu-Radu S, Nandarge PS, Elagez A, Doros G, Lazureanu VE, Stoicescu ER, Tanase E, Iacob R, Dumitrescu A, Bota AV, Cotoraci C, and Bratu ML

Abstract

The long-term sequelae of SARS-CoV-2 infection are still under research, since extensive studies showed plenty of systemic effects of the viral infection, extending even after the acute phase of the infection. This study evaluated kidney function tests six months after SARS-CoV-2 infection in patients clinically diagnosed with Post-COVID Syndrome, hypothesizing persistent renal dysfunction evidenced by altered kidney function tests compared to baseline levels. Continuous eGFR decrease <30 at six months post-infection was considered the main study outcome. Conducted at the "Victor Babes" Hospital, this retrospective observational study involved adults with laboratory-confirmed SARS-CoV-2 infection and clinically-diagnosed Post-COVID Syndrome, excluding those with prior chronic kidney disease or significant renal impairment. Kidney function tests, including serum creatinine, blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), alongside markers of kidney damage such as proteinuria and hematuria, were analyzed. Among 206 participants, significant differences were observed between the control ( n = 114) and the Post-COVID group ( n = 92). The Post-COVID group exhibited higher serum creatinine (109.7 μmol/L vs. 84.5 μmol/L, p < 0.001), lower eGFR (65.3mL/min/1.73 m 2 vs. 91.2 mL/min/1.73 m 2 , p < 0.001), and elevated BUN levels (23.7 mg/dL vs. 15.2 mg/dL, p < 0.001) compared to the control group. Regression analysis highlighted significant predictors of continuous eGFR decrease <30 at six months post-infection. The development of acute kidney injury (AKI) during the initial COVID-19 illness emerged as a strong predictor of reduced eGFR (β = 3.47, p < 0.001). Additional factors, including a creatinine increase (23 μmol/L above the normal range) and an elevated Albumin to Creatinine Ratio (ACR) (>11 mg/g above the normal range), were significantly associated with eGFR reduction. Patients with Post-COVID Syndrome demonstrate significant renal impairment six months post-SARS-CoV-2 infection. The study's findings stress the need for ongoing monitoring and intervention strategies for renal health in affected individuals, underscoring the persistent impact of COVID-19 on renal function., Competing Interests: The authors declare no conflict of interest.

Published
2024
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10. The importance of clinicians' and parents' awareness of suicidal behaviour in adolescents reaching the upper age limit of their mental health services in Europe.

Author

van Bodegom LS, Gerritsen SE, Dieleman GC, Overbeek MM, de Girolamo G, Scocco P, Hillegers MHJ, Wolke D, Rizopoulos D, Appleton R, Conti P, Franić T, Margari F, Madan J, McNicholas F, Nacinovich R, Pastore A, Paul M, Purper-Ouakil D, Saam MC, Santosh PJ, Sartor A, Schulze UME, Signorini G, Singh SP, Street C, Tah P, Tanase E, Tremmery S, Tuomainen H, and Maras A

Subjects
Adult, Child, Humans, Adolescent, Europe, Mental Health, Parents psychology, Suicidal Ideation, Mental Health Services
Abstract

Background: To study clinicians' and parents' awareness of suicidal behaviour in adolescents reaching the upper age limit of their Child and Adolescent Mental Health Service (CAMHS) and its association with mental health indicators, transition recommendations and mental health service (MHS) use., Methods: 763 CAMHS users from eight European countries were assessed using multi-informant and standardised assessment tools at baseline and nine months follow-up. Separate ANCOVA's and pairwise comparisons were conducted to assess whether clinicians' and parents' awareness of young people's suicidal behaviour were associated with mental health indicators, clinician's recommendations to continue treatment and MHS use at nine months follow-up., Results: 53.5 % of clinicians and 56.9 % of parents were unaware of young people's self-reported suicidal behaviour at baseline. Compared to those whose clinicians/parents were aware, unawareness was associated with a 72-80 % lower proportion of being recommended to continue treatment. Self-reported mental health problems at baseline were comparable for young people whose clinicians and parents were aware and unaware of suicidal behaviour. Clinicians' and parents' unawareness were not associated with MHS use at follow-up., Limitations: Aspects of suicidal behaviour, such as suicide ideation, -plans and -attempts, could not be distinguished. Few young people transitioned to Adult Mental Health Services (AMHS), therefore power to study factors associated with AMHS use was limited., Conclusion: Clinicians and parents are often unaware of suicidal behaviour, which decreases the likelihood of a recommendation to continue treatment, but does not seem to affect young people's MHS use or their mental health problems., Competing Interests: Conflict of interest SPS is part-funded by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care West Midlands (NIHR CLAHRC WM), now recommissioned as NIHR Applied Research Collaboration West Midlands. The views expressed in this publication are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. PS is the co-inventor of the HealthTrackerTM and is the Chief Executive Officer and shareholder in HealthTracker Ltd. AM was a speaker and advisor for Neurim, Shire, Infectopharm and Lilly (all not related to transition research)., (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)

Published
2023
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11. Cohort profile: demographic and clinical characteristics of the MILESTONE longitudinal cohort of young people approaching the upper age limit of their child mental health care service in Europe.

Author

Gerritsen SE, Maras A, van Bodegom LS, Overbeek MM, Verhulst FC, Wolke D, Appleton R, Bertani A, Cataldo MG, Conti P, Da Fonseca D, Davidović N, Dodig-Ćurković K, Ferrari C, Fiori F, Franić T, Gatherer C, De Girolamo G, Heaney N, Hendrickx G, Kolozsvari A, Levi FM, Lievesley K, Madan J, Martinelli O, Mastroianni M, Maurice V, McNicholas F, O'Hara L, Paul M, Purper-Ouakil D, de Roeck V, Russet F, Saam MC, Sagar-Ouriaghli I, Santosh PJ, Sartor A, Schandrin A, Schulze UME, Signorini G, Singh SP, Singh J, Street C, Tah P, Tanase E, Tremmery S, Tuffrey A, Tuomainen H, van Amelsvoort TAMJ, Wilson A, Walker L, and Dieleman GC

Subjects
Adolescent, Cohort Studies, Demography, Europe, Humans, Mental Health, Prospective Studies, Retrospective Studies, Adolescent Health Services, Mental Health Services
Abstract

Purpose: The presence of distinct child and adolescent mental health services (CAMHS) and adult mental health services (AMHS) impacts continuity of mental health treatment for young people. However, we do not know the extent of discontinuity of care in Europe nor the effects of discontinuity on the mental health of young people. Current research is limited, as the majority of existing studies are retrospective, based on small samples or used non-standardised information from medical records. The MILESTONE prospective cohort study aims to examine associations between service use, mental health and other outcomes over 24 months, using information from self, parent and clinician reports., Participants: Seven hundred sixty-three young people from 39 CAMHS in 8 European countries, their parents and CAMHS clinicians who completed interviews and online questionnaires and were followed up for 2 years after reaching the upper age limit of the CAMHS they receive treatment at., Findings to Date: This cohort profile describes the baseline characteristics of the MILESTONE cohort. The mental health of young people reaching the upper age limit of their CAMHS varied greatly in type and severity: 32.8% of young people reported clinical levels of self-reported problems and 18.6% were rated to be 'markedly ill', 'severely ill' or 'among the most extremely ill' by their clinician. Fifty-seven per cent of young people reported psychotropic medication use in the previous half year., Future Plans: Analysis of longitudinal data from the MILESTONE cohort will be used to assess relationships between the demographic and clinical characteristics of young people reaching the upper age limit of their CAMHS and the type of care the young person uses over the next 2 years, such as whether the young person transitions to AMHS. At 2 years follow-up, the mental health outcomes of young people following different care pathways will be compared., Trial Registration Number: NCT03013595., Competing Interests: Competing interests: SPS is part-funded by the National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care West Midlands (NIHR CLAHRC WM), now recommissioned as NIHR Applied Research Collaboration West Midlands. The views expressed in this publication are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. PS is the co-inventor of the HealthTrackerTM and is the Chief Executive Officer and shareholder in HealthTracker Ltd. FF is a Chief Technical Officer and AK is the Chief Finance Officer employed by HealthTracker Ltd respectively. FCV publishes the Dutch translations of ASEBA, from which he receives remuneration. AM was a speaker and advisor for Neurim, Shire, Infectopharm and Lilly (all not related to transition research)., (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2021
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12. Physico-chemical characterisation of lipids from Mytilus galloprovincialis (L.) and Rapana venosa and their healing properties on skin burns.

Author

Badiu DL, Balu AM, Barbes L, Luque R, Nita R, Radu M, Tanase E, and Rosoiu N

Subjects
Animals, Burns pathology, Chemical Phenomena, Chemistry, Physical, Gas Chromatography-Mass Spectrometry, Gastropoda chemistry, Male, Rats, Rats, Wistar, Skin blood supply, Skin pathology, Spectrophotometry, Infrared, Spectrophotometry, Ultraviolet, Spectrum Analysis, Wound Healing drug effects, Burns drug therapy, Fatty Acids, Unsaturated therapeutic use, Lipids chemistry, Lipids therapeutic use, Mytilus chemistry
Abstract

Black Sea molluscs and gastropods are the most studied organisms from the Romanian littoral zone. In particular, those from the Mytilidae species are of great interest because biochemical investigations have shown that they can be sources of biological active substances which can have different applications (e.g. food additives). We report here the extraction of lipids from two different species of molluscs (Mytilus galloprovincialis L., Mediterranean mussel) and gastropods (Rapana venosa, hard-shell clam). The extracts were evaluated in terms of antioxidant and composition properties and their healing properties were tested on skin burns in Wistar rats. Our studies proved that the two lipid extracts contained a relatively complex distribution of compounds, in terms of characteristic indices, polyunsaturated fatty acids (PUFA) and vitamins E and D. The presence of such compounds rendered the extracts very efficient in healing induced skin burns in Wistar rats. The histological analysis showed a reduction in the time of healing (12-13 and 13-15 days for the Mytilus galloprovincialis (L.) Rapana venosa extracts, respectively) compared to 20-22 for untreated animals, based on results from tissues and blood samples. Our investigations have been proved to be promising in terms of future potential applications of the extracts as skin-care products, cosmetics and/or pharmaceutical preparations owing to their dermorestitutive properties.

Published
2008
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