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28 results on '"Tancredi, Lucia"'

1. Migraine improvement after spontaneous cervical artery dissection the Italian Project on Stroke in Young Adults (IPSYS)

Author

De Giuli, Valeria, Graziano, Francesca, Zini, Andrea, Zedde, Marialuisa, Patella, Rosalba, Lodigiani, Corrado, Marcheselli, Simona, DeLodovici, Maria Luisa, Paciaroni, Maurizio, Casetta, Ilaria, Giorli, Elisa, Adami, Alessandro, Braga, Massimiliano, Casella, Carmela, Giossi, Alessia, Silvestrelli, Giorgio, Tancredi, Lucia, Lotti, Enrico Maria, Poli, Loris, Caria, Filomena, Piras, Valeria, Cucurachi, Laura, Gamba, Massimo, Grassi, Mario, Padovani, Alessandro, Pezzini, Alessandro, and on behalf of the Italian Project on Stroke in Young Adults (IPSYS) Investigators

Published
2019
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2. Incidence and long-term functional outcome of neurologic disorders in hospitalized COVID-19 patients infected with pre-omicron variants

Author

Beretta, Simone, Cristillo, Viviana, Camera, Giorgia, Morotti Colleoni, Carlo, Pellitteri, Gaia, Viti, Beatrice, Bianchi, Elisa, Gipponi, Stefano, Grimoldi, Maria, Valente, Mariarosaria, Guttmann, Susanna, Cotelli, Maria Sofia, Palumbo, Pasquale, Gelosa, Giorgio, Meletti, Stefano, Schenone, Cristina, Ottaviani, Donatella, Filippi, Massimo, Zini, Andrea, Basilico, Paola, Tancredi, Lucia, Cortelli, Pietro, Braga, Massimiliano, De Giuli, Valeria, Servidei, Serenella, Paolicelli, Damiano, Verde, Federico, Caproni, Stefano, Pisani, Antonio, Lo Re, Vincenzina, Massacesi, Luca, Roccatagliata, Daria Valeria, Manganotti, Paolo, Spitaleri, Daniele L A, Formenti, Anna, Piccoli, Marta, Marino, Silvia, Polverino, Paola, Aguglia, Umberto, Ornello, Raffaele, Perego, Elisabetta, Siciliano, Gabriele, Merlo, Paola, Capobianco, Marco, Pantoni, Leonardo, Lugaresi, Alessandra, Angelocola, Stefania, De Rosa, Anna, Sessa, Maria, Beghi, Ettore, Agostoni, Elio Clemente, Monaco, Salvatore, Padovani, Alessandro, Priori, Alberto, Silani, Vincenzo, Tedeschi, Gioacchino, and Ferrarese, Carlo

Subjects
Incidence studies, Outcome research, COVID-19, Cohort studies
Published
2023

3. SORL1gene mutation and octapeptide repeat insertion inPRNPgene in a case presenting with rapidly progressive dementia and cerebral amyloid angiopathy

Author

Cencini, Federica, primary, Catania, Marcella, additional, Di Fede, Giuseppe, additional, Rossi, Giacomina, additional, Chalouhi, Katia Khouri, additional, Manfredi, Chiara, additional, Giaccone, Giorgio, additional, Tiraboschi, Pietro, additional, Bersano, Anna, additional, Groppo, Elisabetta, additional, Rosci, Chiara, additional, Tancredi, Lucia, additional, Campiglio, Laura, additional, De Grado, Amedeo, additional, Priori, Alberto, additional, and Scelzo, Emma, additional

Published
2022
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4. Clinical Pregenetic Screening for Stroke Monogenic Diseases: Results From Lombardia GENS Registry

Author

Bersano, Anna, Markus, Hugh Stephen, Quaglini, Silvana, Arbustini, Eloisa, Lanfranconi, Silvia, Micieli, Giuseppe, Boncoraglio, Giorgio B., Taroni, Franco, Gellera, Cinzia, Baratta, Silvia, Penco, Silvana, Mosca, Lorena, Grasso, Maurizia, Carrera, Paola, Ferrari, Maurizio, Cereda, Cristina, Grieco, Gaetano, Corti, Stefania, Ronchi, Dario, Bassi, Maria Teresa, Obici, Laura, Parati, Eugenio A., Pezzini, Alessando, De Lodovici, Maria Luisa, Verrengia, Elena P., Bono, Giorgio, Mazucchelli, Francesca, Zarcone, Davide, Calloni, Maria Vittoria, Perrone, Patrizia, Bordo, Bianca Maria, Colombo, Antonio, Padovani, Alessandro, Cavallini, Anna, Beretta, Simone, Ferrarese, Carlo, Motto, Cristina, Agostoni, Elio, Molini, Graziella, Sasanelli, Francesco, Corato, Manuel, Marcheselli, Simona, Sessa, Maria, Comi, Giancarlo, Checcarelli, Nicoletta, Guidotti, Mario, Uccellini, Davide, Capitani, Erminio, Tancredi, Lucia, Arnaboldi, Marco, Incorvaia, Barbara, Tadeo, Carlo Sebastiano, Fusi, Laura, Grampa, Giampiero, Merlini, Giampaolo, Trobia, Nadia, Comi, Giacomo Pietro, Braga, Massimiliano, Vitali, Paolo, Baron, Pierluigi, Grond-Ginsbach, Caspar, and Candelise, Livia

Published
2016
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6. Neurological disorders associated with COVID-19 infection: An Italian multi-center cohort study (NEURO-COVID)

Author

Beretta, Simone, Cristillo, Viviana, Viti, Beatrice, Colleoni, Carlo Morotti, Bianchi, Elisa, Silani, Vincenzo, Priori, Alberto, Padovani, Alessandro, Pilotto, Andrea, Guttmann, Susanna, Barvas, Edoardo, Palumbo, Pasquale, Bartolini, Emanuele, Turla, Marinella, Cotelli, Maria Sofia, Bax, Francesco, Gigli, Gian Luigi, Viganò, Martina, Sessa, Maria, Ciolli, Ludovico, Maffei, Stefania, Meletti, Stefano, Tancredi, Lucia, De Giuli, Valeria, Censori, Bruno, Benedetti, Luana, Pardini, Matteo, Schenone, Angelo, Orrico, Mario, Sferruzza, Giacomo, Filippi, Massimo, Braga, Massimiliano, Beretta, Sandro, Calcagno, Narghes, Trogu, Francesca, Primiano, Guido, Servidei, Serenella, Ranchicchio, Prabha Cristina, Caproni, Stefano, Gentile, Mauro, Cortelli, Pietro, Zini, Andrea, Beghi, Ettore, Tedeschi, Gioacchino, and Ferrarese, Carlo

Published
2021
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7. Subclinical Vascular Brain Lesions in Young Adults With Acute Ischemic Stroke

Author

De Giuli, Valeria, primary, Grassi, Mario, additional, Besana, Michele, additional, Zedde, Marialuisa, additional, Zini, Andrea, additional, Lodigiani, Corrado, additional, Marcheselli, Simona, additional, Cavallini, Anna, additional, Micieli, Giuseppe, additional, Rasura, Maurizia, additional, DeLodovici, Maria Luisa, additional, Tomelleri, Giampaolo, additional, Checcarelli, Nicoletta, additional, Chiti, Alberto, additional, Giorli, Elisa, additional, Del Sette, Massimo, additional, Tancredi, Lucia, additional, Toriello, Antonella, additional, Braga, Massimiliano, additional, Morotti, Andrea, additional, Pezzini, Debora, additional, Locatelli, Martina, additional, Mazzoleni, Valentina, additional, Bonacina, Sonia, additional, Gamba, Massimo, additional, Magoni, Mauro, additional, Patella, Rosalba, additional, Spalloni, Alessandra, additional, Maria Simone, Anna, additional, Pascarella, Rosario, additional, Beretta, Sandro, additional, Padovani, Alessandro, additional, Gasparotti, Roberto, additional, Pezzini, Alessandro, additional, Gilberti, Nicola, additional, Ferrazzi, Paola, additional, Banfi, Elena, additional, Librè, Luca, additional, Traverso, Elisabetta, additional, Schirinzi, Erika, additional, Carimati, Federico, additional, Cappellari, Manuel, additional, Locatelli, Giampiero, additional, Demelas, Laura, additional, Ferrario, Davide, additional, Persico, Alessandra, additional, Orlandi, Giovanni, additional, Napoli, Manuela, additional, Moratti, Claudio, additional, and Guidotti, Mario, additional

Published
2021
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9. SORL1 gene mutation and octapeptide repeat insertion in PRNP gene in a case presenting with rapidly progressive dementia and cerebral amyloid angiopathy.

Author

Cencini, Federica, Catania, Marcella, Di Fede, Giuseppe, Rossi, Giacomina, Chalouhi, Katia Khouri, Manfredi, Chiara, Giaccone, Giorgio, Tiraboschi, Pietro, Bersano, Anna, Groppo, Elisabetta, Rosci, Chiara, Tancredi, Lucia, Campiglio, Laura, De Grado, Amedeo, Priori, Alberto, and Scelzo, Emma

Subjects
CEREBRAL amyloid angiopathy, ALZHEIMER'S disease, MYOCLONUS, PRION diseases, GENETIC mutation, TAU proteins, MAGNETIC resonance imaging
Abstract

Background and purpose: Cerebral amyloid angiopathy (CAA) has been associated with a variety of neurodegenerative disorders, included prion diseases and Alzheimer's disease; its pathophysiology is still largely unknown. We report the case of an 80‐year‐old man with rapidly progressive dementia and neuroimaging features consistent with CAA carrying two genetic defects in the PRNP and SORL1 genes. Methods: Neurological examination, brain magnetic resonance imaging (MRI), electroencephalographic–electromyographic (EEG–EMG) polygraphy, and analysis of 14‐3‐3 and tau proteins, Aβ40, and Aβ42 in the cerebrospinal fluid (CSF) were performed. The patient underwent a detailed genetic study by next generation sequencing analysis. Results: The patient presented with progressive cognitive dysfunction, generalized myoclonus, and ataxia. Approximately 9 months after symptom onset, he was bed‐bound, almost mute, and akinetic. Brain MRI was consistent with CAA. CSF analysis showed high levels of t‐tau and p‐tau, decreased Aβ42, decreased Aβ42/Aβ40 ratio, and absence of 14.3.3 protein. EEG–EMG polygraphy demonstrated diffuse slowing, frontal theta activity, and generalized spike‐waves related to upper limb myoclonus induced by intermittent photic stimulation. Genetic tests revealed the presence of the E270K variant in the SORL1 gene and the presence of a single octapeptide repeat insertion in the coding region of the PRNP gene. Conclusions: The specific pathogenic contribution of the two DNA variations is difficult to determine without neuropathology; among the possible explanations, we discuss the possibility of their link with CAA. Vascular and degenerative pathways actually interact in a synergistic way, and genetic studies may lead to more insight into pathophysiological mechanisms. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Hildegarde de Bingen : La puissance et la grâce

Author

Tancredi, Lucia, Tancredi, Lucia, Tancredi, Lucia, and Tancredi, Lucia

Abstract

Au fil de sa plume Lucia Tancredi nous révèle un personnage attachant et visionnaire. « On donne souvent en exemple des vies de saints qui dès leur plus jeune âge connaissent la route et la parcourent en allant tout droit Moi j’étais une petite fille dont le fragile envol avait été entravé par une chaîne cruelle. C’est pour cela que le Seigneur m’accorde de vivre encore à quatre-vingt-deux ans. J’ai besoin de beaucoup de temps pour comprendre et pour me comprendre. L’amour n’arrive jamais tout de suite. Il faut toujours une très longue effraction du cœur.» Cette vie d’Hildegarde de Bingen se présente comme un roman historique et se base sur la trame vraisemblable d’une biographie dictée, non à des hommes comme les textes que l’on connaît, mais à la moniale Adélaïde, qui vécut aux côtés d’Hildegarde jusqu’à sa mort. Le récit recueilli par une femme permet une reconstruction intime et fidèle, capable de décrire la vie extraordinaire d’une figure comme Hildegarde, mystique étonnante, amie des reines et des empereurs, à la fois témoin génial de son temps et considérablement en avance sur son époque, mais aussi enfant dans l’enceinte de l’abbaye, fille éprouvée, éducatrice affectueuse et maternelle, musicienne et guérisseuse, capable de trouver, dans les subtilités de la nature, le secret pour se sentir en harmonie avec la beauté et le don de la création. Hildegarde de Bingen est Docteur de l’Église (proclamation par Benoît XVI le 7 octobre 2012), quatrième femme à recevoir ce titre, à la suite de Catherine de Sienne. Thérèse d’Avila et Thérèse de Lisieux. Découvrez la biographie romancée d'une femme d'Église au parcours exemplaire. EXTRAIT Je vis le jour au déclin de l’été. Ma mère Mechtilde était convaincue que l’obscurité allait venir bien vite avec la pluie, en cette année plus froide que jamais. Elle était déjà vieille. Neuf grossesses l’avaient éreintée dans son corps et dans son âme. Lorsqu’elle parlait son visage devenait anguleux. Elle avait des mains petites et

Published
2018

12. Retrospective study of a large population of patients affected with mitochondrial disorders: clinical, morphological and molecular genetic evaluation

Author

Sciacco, Monica, Prelle, Alessandro, Comi, Giacomo P., Napoli, Laura, Battistel, Alessandro, Bresolin, Nereo, Tancredi, Lucia, Lamperti, Costanza, Bordoni, Adreina, Fagiolari, Gigliola, Ciscato, Patrizia, Chiveri, Luca, Perini, Maria Paola, Fortunato, Francesco, Adobbati, Laura, Messina, Stefano, Toscano, Antonio, Martinelli-Boneschi, Filippo, Papadimitriou, Alex, Scarlato, Guglielmo, and Moggio, Maurizio

Published
2001
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13. Subclinical Vascular Brain Lesions in Young Adults With Acute Ischemic Stroke.

Author

De Giuli, Valeria, Grassi, Mario, Besana, Michele, Zedde, Marialuisa, Zini, Andrea, Lodigiani, Corrado, Marcheselli, Simona, Cavallini, Anna, Micieli, Giuseppe, Rasura, Maurizia, DeLodovici, Maria Luisa, Tomelleri, Giampaolo, Checcarelli, Nicoletta, Chiti, Alberto, Giorli, Elisa, Del Sette, Massimo, Tancredi, Lucia, Toriello, Antonella, Braga, Massimiliano, and Morotti, Andrea

Published
2022
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15. The role of clinical and neuroimaging features in the diagnosis of CADASIL

Author

Bersano, Anna, Bedini, Gloria, Markus, Hugh Stephen, Vitali, Paolo, Colli-Tibaldi, Enrico, Taroni, Franco, Gellera, Cinzia, Baratta, Silvia, Mosca, Lorena, Carrera, Paola, Ferrari, Maurizio, Cereda, Cristina, Grieco, Gaetano, Lanfranconi, Silvia, Mazucchelli, Franca, Zarcone, Davide, De Lodovici, Maria Luisa, Bono, Giorgio, Boncoraglio, Giorgio Battista, Parati, Eugenio Agostino, Calloni, Maria Vittoria, Perrone, Patrizia, Bordo, Bianca Maria, Motto, Cristina, Agostoni, Elio, Pezzini, Alessandro, Padovani, Alessandro, Micieli, Giuseppe, Cavallini, Anna, Molini, Graziella, Sasanelli, Francesco, Sessa, Maria, Comi, Giancarlo, Checcarelli, Nicoletta, Carmerlingo, Massimo, Corato, Manuel, Marcheselli, Simona, Fusi, Laura, Grampa, Giampiero, Uccellini, Davide, Beretta, Simone, Ferrarese, Carlo, Incorvaia, Barbara, Tadeo, Carlo Sebastiano, Adobbati, Laura, Silani, Vincenzo, Faragò, Giuseppe, Trobia, Nadia, Grond-Ginsbach, Caspar, Candelise, Livia, Mazzucchelli, Franca, Guidotti, Mario, Riva, Maurizio, Iurlaro, Simona, Maria, Bianca Bordo, Braga, Massimiliano, Meola, Giovanni, Carpo, Marinella, Camerlingo, Massimo, Borutti, Giuseppina, Delodovici, Marialuisa, Verrengia, Elena Pinuccia, Tancredi, Lucia, Terruzzi, Alessandro, Magoni, Mauro, Del Zotto, Elisabetta, Bassi, Pietro, Lattuada, Patrizia, Ballabio, Elena, Gambaro, Paola, Lanfranconi, Sivia, Corrà, Barbara, Canavero, Isabella, Arbustini, Eloisa, Grasso, Maurizia, Comi, Giacomo Pietro, Corti, Stefania, Ronchi, Dario, Merlini, Giampaolo, Obici, Laura, Bassi, Maria Teresa, Tagliavini, Fabrizio, Ginsbach, Caspar Grond, Bersano, Anna, Bedini, Gloria, Markus, Hugh Stephen, Vitali, Paolo, Colli-Tibaldi, Enrico, Taroni, Franco, Gellera, Cinzia, Baratta, Silvia, Mosca, Lorena, Carrera, Paola, Ferrari, Maurizio, Cereda, Cristina, Grieco, Gaetano, Lanfranconi, Silvia, Mazucchelli, Franca, Zarcone, Davide, De Lodovici, Maria Luisa, Bono, Giorgio, Boncoraglio, Giorgio Battista, Parati, Eugenio Agostino, Calloni, Maria Vittoria, Perrone, Patrizia, Bordo, Bianca Maria, Motto, Cristina, Agostoni, Elio, Pezzini, Alessandro, Padovani, Alessandro, Micieli, Giuseppe, Cavallini, Anna, Molini, Graziella, Sasanelli, Francesco, Sessa, Maria, Comi, Giancarlo, Checcarelli, Nicoletta, Carmerlingo, Massimo, Corato, Manuel, Marcheselli, Simona, Fusi, Laura, Grampa, Giampiero, Uccellini, Davide, Beretta, Simone, Ferrarese, Carlo, Incorvaia, Barbara, Tadeo, Carlo Sebastiano, Adobbati, Laura, Silani, Vincenzo, Faragò, Giuseppe, Trobia, Nadia, Grond-Ginsbach, Caspar, Candelise, Livia, Mazzucchelli, Franca, Guidotti, Mario, Riva, Maurizio, Iurlaro, Simona, Maria, Bianca Bordo, Braga, Massimiliano, Meola, Giovanni, Carpo, Marinella, Camerlingo, Massimo, Borutti, Giuseppina, Delodovici, Marialuisa, Verrengia, Elena Pinuccia, Tancredi, Lucia, Terruzzi, Alessandro, Magoni, Mauro, Del Zotto, Elisabetta, Bassi, Pietro, Lattuada, Patrizia, Ballabio, Elena, Gambaro, Paola, Lanfranconi, Sivia, Corrà, Barbara, Canavero, Isabella, Arbustini, Eloisa, Grasso, Maurizia, Comi, Giacomo Pietro, Corti, Stefania, Ronchi, Dario, Merlini, Giampaolo, Obici, Laura, Bassi, Maria Teresa, Tagliavini, Fabrizio, Ginsbach, Caspar Grond, Bersano, A, Bedini, G, Markus, H, Vitali, P, Colli-Tibaldi, E, Taroni, F, Gellera, C, Baratta, S, Mosca, L, Carrera, P, Ferrari, M, Cereda, C, Grieco, G, Lanfranconi, S, Mazucchelli, F, Zarcone, D, De Lodovici, M, Bono, G, Boncoraglio, G, Parati, E, Calloni, M, Perrone, P, Bordo, B, Motto, C, Agostoni, E, Pezzini, A, Padovani, A, Micieli, G, Cavallini, A, Molini, G, Sasanelli, F, Sessa, M, Comi, G, Checcarelli, N, Carmerlingo, M, Corato, M, Marcheselli, S, Fusi, L, Grampa, G, Uccellini, D, Beretta, S, Ferrarese, C, Incorvaia, B, Tadeo, C, Adobbati, L, Silani, V, Faragò, G, Trobia, N, Grond-Ginsbach, C, Candelise, L, Mazzucchelli, F, Guidotti, M, Riva, M, Iurlaro, S, Maria, B, Braga, M, Meola, G, Carpo, M, Camerlingo, M, Borutti, G, Delodovici, M, Verrengia, E, Tancredi, L, Terruzzi, A, Magoni, M, Del Zotto, E, Bassi, P, Lattuada, P, Ballabio, E, Gambaro, P, Corrà, B, Canavero, I, Arbustini, E, Grasso, M, Corti, S, Ronchi, D, Merlini, G, Obici, L, Bassi, M, Tagliavini, F, Ginsbach, C, Markus, Hugh [0000-0002-9794-5996], and Apollo - University of Cambridge Repository

Subjects
Adult, Male, Brain hemorrhage, medicine.medical_specialty, Neurology, White matter lesion, Monogenic disorder, CADASIL, Neuroimaging, Gene mutation, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Diagnosis, Medicine, Dementia, Humans, cardiovascular diseases, Prospective Studies, Receptor, Notch3, Neuroradiology, Aged, Cerebral Hemorrhage, Stroke genetics, Monogenic disorders, business.industry, Brain, Middle Aged, medicine.disease, Magnetic Resonance Imaging, White Matter, Prospective Studie, Ischemic Attack, Transient, Stroke genetic, Stroke, Lacunar, Female, Neurology (clinical), Atrophy, business, Neuroscience, NOTCH3 gene, 030217 neurology & neurosurgery, Diagnosi, Human
Abstract

BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common familial cerebral small vessel disease, caused by NOTCH3 gene mutations. The aim of our study was to identify clinical and neuroradiological features which would be useful in identifying which patients presenting with lacunar stroke and TIA are likely to have CADASIL. METHODS: Patients with lacunar stroke or TIA were included in the present study. For each patient, demographic and clinical data were collected. MRI images were centrally analysed for the presence of lacunar infarcts, microbleeds, temporal lobe involvement, global atrophy and white matter hyperintensities. RESULTS: 128 patients (mean age 56.3 ± 12.4 years) were included. A NOTCH3 mutation was found in 12.5% of them. A family history of stroke, the presence of dementia and external capsule lesions on MRI were the only features significantly associated with the diagnosis of CADASIL. Although thalamic, temporal pole gliosis and severe white matter hyperintensities were less specific for CADASIL diagnosis, the combination of a number of these factors together with familial history for stroke result in a higher positive predictive value and specificity. CONCLUSIONS: A careful familial history collection and neuroradiological assessment can identify patients in whom NOTCH3 genetic testing has a higher yield., The Lombardia GENS project has received funding from the Regione Lombardia Government as a Research Independent Project (DGR n°VIII/006128-12/12/2007). Lombardia GENS is an investigator-driven, academic, non-profit consortium and is publicly funded. Hugh Markus is supported by an NIHR Senior Investigator award and his work is supported by the Cambridge University Hospitals NIHR Biomedical Research Centre

Published
2018

16. Screening for Fabry disease in patients with ischaemic stroke at young age: the Italian Project on Stroke in Young Adults

Author

Poli, L., Zedde, Marialuisa, Zini, Andrea, Del Sette, Massimo, Lodigiani, Corrado, Spalloni, Alessandra, Di Lisi, Filomena, Toriello, Antonella, Piras, Valeria, Stilo, Cesare, Tomelleri, Giampaolo, Tancredi, Lucia, Paciaroni, Maurizio, Silvestrelli, Giorgio, Adami, Alessandro, Costa, P., Morotti, A., De Giuli, V., Caria, F., Gamba, Massimo, Malferrari, Giovanni, Simone, Anna Maria, Musolino, Rossella, Giorli, Elisa, Banfi, Elena, Marcheselli, Simona, Rasura, Maurizia, Pugliese, Nicola, Melis, Maurizio, Bovi, Paolo, Padovani, A., Burlina, A., Pezzini, A, Del Zotto, Elisabetta, Giossi, Alessia, Sessa, Maria, Gilberti, Nicola, Magoni, Mauro, Ferrazzi, Paola, Librã¨, Luca, Rota, Lidia Luciana, Patella, Rosalba, Calabrã², Rocco Salvatore, Bramanti, Placido, La Spina, Paolo, Finocchi, Cinzia, Balestrino, Maurizio, Bruno, Chiara, Massucco, Davide, Gandolfo, Carlo, Traverso, Elisabetta, Delodovici, Maria Luisa, Verrengia, Elena Pinuccia, Carimati, Federico, Bono, GIORGIO GIOVANNI, Dell'Acqua, Maria Luisa, Bigliardi, Guido, Vandelli, Laura, Nichelli, Paolo Frigio, Carletti, Monica, Cerrato, Paolo, Iacoviello, Licia, Di Castelnuovo, Augusto, de Gaetano, Giovanni, Grassi, Mario, Locatelli, Giampiero, Caso, Valeria, D'Amore, Cataldo, Agnelli, Giancarlo, Checcarelli, Nicoletta, Guidotti, Mario, Arnaboldi, Marco, Giacalone, Giacomo, Zanoli, Elisa, Cavallini, Anna, Persico, Alessandra, Micieli, Giuseppe, Chiti, Alberto, Orlandi, Giovanni, Marchi, Piernicola, Lanari, Alessia, Ciccone, Alfonso, Cucurachi, Laura, Bonifati, Marco Domenico, and Marcello, Norina

Subjects
Pediatrics, medicine.medical_specialty, Neurology, 030204 cardiovascular system & hematology, Fabry disease, ischaemic, stroke, young, Neurology (clinical), Brain ischemia, 03 medical and health sciences, 0302 clinical medicine, Ischaemic stroke, Medicine, In patient, cardiovascular diseases, Young adult, Stroke, business.industry, medicine.disease, Young age, business, 030217 neurology & neurosurgery
Published
2017
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17. The role of clinical and neuroimaging features in the diagnosis of CADASIL

Author

Bersano, A, Bedini, G, Markus, H, Vitali, P, Colli-Tibaldi, E, Taroni, F, Gellera, C, Baratta, S, Mosca, L, Carrera, P, Ferrari, M, Cereda, C, Grieco, G, Lanfranconi, S, Mazucchelli, F, Zarcone, D, De Lodovici, M, Bono, G, Boncoraglio, G, Parati, E, Calloni, M, Perrone, P, Bordo, B, Motto, C, Agostoni, E, Pezzini, A, Padovani, A, Micieli, G, Cavallini, A, Molini, G, Sasanelli, F, Sessa, M, Comi, G, Checcarelli, N, Carmerlingo, M, Corato, M, Marcheselli, S, Fusi, L, Grampa, G, Uccellini, D, Beretta, S, Ferrarese, C, Incorvaia, B, Tadeo, C, Adobbati, L, Silani, V, Faragò, G, Trobia, N, Grond-Ginsbach, C, Candelise, L, Mazzucchelli, F, Guidotti, M, Riva, M, Iurlaro, S, Maria, B, Braga, M, Meola, G, Carpo, M, Camerlingo, M, Borutti, G, Delodovici, M, Verrengia, E, Tancredi, L, Terruzzi, A, Magoni, M, Del Zotto, E, Bassi, P, Lattuada, P, Ballabio, E, Gambaro, P, Corrà, B, Canavero, I, Arbustini, E, Grasso, M, Corti, S, Ronchi, D, Merlini, G, Obici, L, Bassi, M, Tagliavini, F, Ginsbach, C, Bersano, Anna, BEDINI, GLORIA, Markus, Hugh Stephen, Vitali, Paolo, Colli-Tibaldi, Enrico, Taroni, Franco, Gellera, Cinzia, Baratta, Silvia, Mosca, Lorena, Carrera, Paola, FERRARI, MAURIZIO, Cereda, Cristina, Grieco, Gaetano, Lanfranconi, Silvia, Mazucchelli, Franca, Zarcone, Davide, De Lodovici, Maria Luisa, Bono, Giorgio, Boncoraglio, Giorgio Battista, Parati, Eugenio Agostino, Calloni, Maria Vittoria, Perrone, Patrizia, Bordo, Bianca Maria, Motto, Cristina, Agostoni, Elio, Pezzini, Alessandro, Padovani, Alessandro, Micieli, Giuseppe, Cavallini, Anna, Molini, Graziella, Sasanelli, Francesco, Sessa, Maria, Comi, Giancarlo, Checcarelli, Nicoletta, Carmerlingo, Massimo, CORATO, MANUEL, Marcheselli, Simona, Fusi, Laura, Grampa, Giampiero, Uccellini, Davide, Beretta, Simone, Ferrarese, Carlo, Incorvaia, Barbara, Tadeo, Carlo Sebastiano, Adobbati, Laura, Silani, Vincenzo, Faragò, Giuseppe, Trobia, Nadia, Grond-Ginsbach, Caspar, Candelise, Livia, Mazzucchelli, Franca, Guidotti, Mario, Riva, Maurizio, Iurlaro, Simona, Maria, Bianca Bordo, Braga, Massimiliano, Meola, Giovanni, Carpo, Marinella, Camerlingo, Massimo, Borutti, Giuseppina, Delodovici, Marialuisa, Verrengia, Elena Pinuccia, Tancredi, Lucia, Terruzzi, Alessandro, Magoni, Mauro, Del Zotto, Elisabetta, Bassi, Pietro, Lattuada, Patrizia, Ballabio, Elena, Gambaro, Paola, Lanfranconi, Sivia, Corrà, Barbara, Canavero, Isabella, Arbustini, Eloisa, Grasso, Maurizia, Comi, Giacomo Pietro, Corti, Stefania, Ronchi, Dario, Merlini, Giampaolo, Obici, Laura, Bassi, Maria Teresa, Tagliavini, Fabrizio, Ginsbach, Caspar Grond, Bersano, A, Bedini, G, Markus, H, Vitali, P, Colli-Tibaldi, E, Taroni, F, Gellera, C, Baratta, S, Mosca, L, Carrera, P, Ferrari, M, Cereda, C, Grieco, G, Lanfranconi, S, Mazucchelli, F, Zarcone, D, De Lodovici, M, Bono, G, Boncoraglio, G, Parati, E, Calloni, M, Perrone, P, Bordo, B, Motto, C, Agostoni, E, Pezzini, A, Padovani, A, Micieli, G, Cavallini, A, Molini, G, Sasanelli, F, Sessa, M, Comi, G, Checcarelli, N, Carmerlingo, M, Corato, M, Marcheselli, S, Fusi, L, Grampa, G, Uccellini, D, Beretta, S, Ferrarese, C, Incorvaia, B, Tadeo, C, Adobbati, L, Silani, V, Faragò, G, Trobia, N, Grond-Ginsbach, C, Candelise, L, Mazzucchelli, F, Guidotti, M, Riva, M, Iurlaro, S, Maria, B, Braga, M, Meola, G, Carpo, M, Camerlingo, M, Borutti, G, Delodovici, M, Verrengia, E, Tancredi, L, Terruzzi, A, Magoni, M, Del Zotto, E, Bassi, P, Lattuada, P, Ballabio, E, Gambaro, P, Corrà, B, Canavero, I, Arbustini, E, Grasso, M, Corti, S, Ronchi, D, Merlini, G, Obici, L, Bassi, M, Tagliavini, F, Ginsbach, C, Bersano, Anna, BEDINI, GLORIA, Markus, Hugh Stephen, Vitali, Paolo, Colli-Tibaldi, Enrico, Taroni, Franco, Gellera, Cinzia, Baratta, Silvia, Mosca, Lorena, Carrera, Paola, FERRARI, MAURIZIO, Cereda, Cristina, Grieco, Gaetano, Lanfranconi, Silvia, Mazucchelli, Franca, Zarcone, Davide, De Lodovici, Maria Luisa, Bono, Giorgio, Boncoraglio, Giorgio Battista, Parati, Eugenio Agostino, Calloni, Maria Vittoria, Perrone, Patrizia, Bordo, Bianca Maria, Motto, Cristina, Agostoni, Elio, Pezzini, Alessandro, Padovani, Alessandro, Micieli, Giuseppe, Cavallini, Anna, Molini, Graziella, Sasanelli, Francesco, Sessa, Maria, Comi, Giancarlo, Checcarelli, Nicoletta, Carmerlingo, Massimo, CORATO, MANUEL, Marcheselli, Simona, Fusi, Laura, Grampa, Giampiero, Uccellini, Davide, Beretta, Simone, Ferrarese, Carlo, Incorvaia, Barbara, Tadeo, Carlo Sebastiano, Adobbati, Laura, Silani, Vincenzo, Faragò, Giuseppe, Trobia, Nadia, Grond-Ginsbach, Caspar, Candelise, Livia, Mazzucchelli, Franca, Guidotti, Mario, Riva, Maurizio, Iurlaro, Simona, Maria, Bianca Bordo, Braga, Massimiliano, Meola, Giovanni, Carpo, Marinella, Camerlingo, Massimo, Borutti, Giuseppina, Delodovici, Marialuisa, Verrengia, Elena Pinuccia, Tancredi, Lucia, Terruzzi, Alessandro, Magoni, Mauro, Del Zotto, Elisabetta, Bassi, Pietro, Lattuada, Patrizia, Ballabio, Elena, Gambaro, Paola, Lanfranconi, Sivia, Corrà, Barbara, Canavero, Isabella, Arbustini, Eloisa, Grasso, Maurizia, Comi, Giacomo Pietro, Corti, Stefania, Ronchi, Dario, Merlini, Giampaolo, Obici, Laura, Bassi, Maria Teresa, Tagliavini, Fabrizio, and Ginsbach, Caspar Grond

Abstract

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common familial cerebral small vessel disease, caused by NOTCH3 gene mutations. The aim of our study was to identify clinical and neuroradiological features which would be useful in identifying which patients presenting with lacunar stroke and TIA are likely to have CADASIL. Methods: Patients with lacunar stroke or TIA were included in the present study. For each patient, demographic and clinical data were collected. MRI images were centrally analysed for the presence of lacunar infarcts, microbleeds, temporal lobe involvement, global atrophy and white matter hyperintensities. Results: 128 patients (mean age 56.3 ± 12.4 years) were included. A NOTCH3 mutation was found in 12.5% of them. A family history of stroke, the presence of dementia and external capsule lesions on MRI were the only features significantly associated with the diagnosis of CADASIL. Although thalamic, temporal pole gliosis and severe white matter hyperintensities were less specific for CADASIL diagnosis, the combination of a number of these factors together with familial history for stroke result in a higher positive predictive value and specificity. Conclusions: A careful familial history collection and neuroradiological assessment can identify patients in whom NOTCH3 genetic testing has a higher yield.

Published
2018

20. Propensity Score–Based Analysis of Percutaneous Closure Versus Medical Therapy in Patients With Cryptogenic Stroke and Patent Foramen Ovale

Author

Pezzini, Alessandro, primary, Grassi, Mario, additional, Lodigiani, Corrado, additional, Patella, Rosalba, additional, Gandolfo, Carlo, additional, Zini, Andrea, additional, DeLodovici, Maria Luisa, additional, Paciaroni, Maurizio, additional, Del Sette, Massimo, additional, Toriello, Antonella, additional, Musolino, Rossella, additional, Calabrò, Rocco Salvatore, additional, Bovi, Paolo, additional, Adami, Alessandro, additional, Silvestrelli, Giorgio, additional, Sessa, Maria, additional, Cavallini, Anna, additional, Marcheselli, Simona, additional, Marco Bonifati, Domenico, additional, Checcarelli, Nicoletta, additional, Tancredi, Lucia, additional, Chiti, Alberto, additional, Del Zotto, Elisabetta, additional, Tomelleri, Giampaolo, additional, Spalloni, Alessandra, additional, Giorli, Elisa, additional, Costa, Paolo, additional, Giacalone, Giacomo, additional, Ferrazzi, Paola, additional, Poli, Loris, additional, Morotti, Andrea, additional, Piras, Valeria, additional, Rasura, Maurizia, additional, Simone, Anna Maria, additional, Gamba, Massimo, additional, Cerrato, Paolo, additional, Zedde, Maria Luisa, additional, Micieli, Giuseppe, additional, Melis, Maurizio, additional, Massucco, Davide, additional, Guido, Davide, additional, De Giuli, Valeria, additional, Bonaiti, Silvia, additional, D’Amore, Cataldo, additional, La Starza, Sara, additional, Iacoviello, Licia, additional, and Padovani, Alessandro, additional

Published
2016
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21. Determinants of premature familial arterial thrombosis in patients with juvenile ischaemic stroke

Author

Pezzini, Alessandro, primary, Grassi, Mario, primary, Lodigiani, Corrado, primary, Patella, Rosalba, primary, Gandolfo, Carlo, primary, Zini, Andrea, primary, DeLodovici, Maria Luisa, primary, Paciaroni, Maurizio, primary, Del Sette, Massimo, primary, Toriello, Antonella, primary, Musolino, Rossella, primary, Calabrò, Rocco Salvatore, primary, Bovil, Paolo, primary, Adami, Alessandro, primary, Silvestrelli, Giorgio, primary, Sessa, Maria, primary, Cavallini, Anna, primary, Marcheselli, Simona, primary, Bonifati, Domenico Marco, primary, Checcarelli, Nicoletta, primary, Tancredi, Lucia, primary, Chiti, Alberto, primary, Del Zotto, Elisabetta, primary, Spalloni, Alessandra, primary, Costa, Paolo, primary, Giacalone, Giacomo, primary, Ferrazzi, Paola, primary, Poli, Loris, primary, Andrea, Morotti, primary, Maurizia, Rasura, primary, Simone, Anna Maria, primary, Gamba, Massimo, primary, Cerrato, Paolo, primary, Micieli, Giuseppe, primary, Melis, Maurizio, primary, Massucco, Davide, primary, De Giuli, Valeria, primary, Pepe, Daniele, primary, Iacoviello, Licia, primary, and Padovani, Alessandro, additional

Published
2015
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22. Predictors of Long-Term Recurrent Vascular Events After Ischemic Stroke at Young Age

Author

Pezzini, Alessandro, primary, Grassi, Mario, additional, Lodigiani, Corrado, additional, Patella, Rosalba, additional, Gandolfo, Carlo, additional, Zini, Andrea, additional, DeLodovici, Maria Luisa, additional, Paciaroni, Maurizio, additional, Del Sette, Massimo, additional, Toriello, Antonella, additional, Musolino, Rossella, additional, Calabrò, Rocco Salvatore, additional, Bovi, Paolo, additional, Adami, Alessandro, additional, Silvestrelli, Giorgio, additional, Sessa, Maria, additional, Cavallini, Anna, additional, Marcheselli, Simona, additional, Bonifati, Domenico Marco, additional, Checcarelli, Nicoletta, additional, Tancredi, Lucia, additional, Chiti, Alberto, additional, Del Zotto, Elisabetta, additional, Spalloni, Alessandra, additional, Giossi, Alessia, additional, Volonghi, Irene, additional, Costa, Paolo, additional, Giacalone, Giacomo, additional, Ferrazzi, Paola, additional, Poli, Loris, additional, Morotti, Andrea, additional, Rasura, Maurizia, additional, Simone, Anna Maria, additional, Gamba, Massimo, additional, Cerrato, Paolo, additional, Micieli, Giuseppe, additional, Melis, Maurizio, additional, Massucco, Davide, additional, De Giuli, Valeria, additional, Iacoviello, Licia, additional, and Padovani, Alessandro, additional

Published
2014
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23. Association Between Migraine and Cervical Artery Dissection: The Italian Project on Stroke in Young Adults

Author

De Giuli, Valeria, Grassi, Mario, Lodigiani, Corrado, Patella, Rosalba, Zedde, Marialuisa, Gandolfo, Carlo, Zini, Andrea, DeLodovici, Maria Luisa, Paciaroni, Maurizio, Del Sette, Massimo, Azzini, Cristiano, Toriello, Antonella, Musolino, Rossella, Calabrò, Rocco Salvatore, Bovi, Paolo, Sessa, Maria, Adami, Alessandro, Silvestrelli, Giorgio, Cavallini, Anna, Marcheselli, Simona, Bonifati, Domenico Marco, Checcarelli, Nicoletta, Tancredi, Lucia, Chiti, Alberto, Lotti, Enrico Maria, Del Zotto, Elisabetta, Tomelleri, Giampaolo, Spalloni, Alessandra, Giorli, Elisa, Costa, Paolo, Poli, Loris, Morotti, Andrea, Caria, Filomena, Lanari, Alessia, Giacalone, Giacomo, Ferrazzi, Paola, Giossi, Alessia, Piras, Valeria, Massucco, Davide, D’Amore, Cataldo, Di Lisi, Filomena, Casetta, Ilaria, Cucurachi, Laura, Cotroneo, Masina, De Vito, Alessandro, Coloberti, Elisa, Rasura, Maurizia, Simone, Anna Maria, Gamba, Massimo, Cerrato, Paolo, Micieli, Giuseppe, Malferrari, Giovanni, Melis, Maurizio, Iacoviello, Licia, Padovani, Alessandro, and Pezzini, Alessandro

Abstract

IMPORTANCE: Although sparse observational studies have suggested a link between migraine and cervical artery dissection (CEAD), any association between the 2 disorders is still unconfirmed. This lack of a definitive conclusion might have implications in understanding the pathogenesis of both conditions and the complex relationship between migraine and ischemic stroke (IS). OBJECTIVE: To investigate whether a history of migraine and its subtypes is associated with the occurrence of CEAD. DESIGN, SETTING, AND PARTICIPANTS: A prospective cohort study of consecutive patients aged 18 to 45 years with first-ever acute ischemic stroke enrolled in the multicenter Italian Project on Stroke in Young Adults was conducted between January 1, 2000, and June 30, 2015. In a case-control design, the study assessed whether the frequency of migraine and its subtypes (presence or absence of an aura) differs between patients whose IS was due to CEAD (CEAD IS) and those whose IS was due to a cause other than CEAD (non-CEAD IS) and compared the characteristics of patients with CEAD IS with and without migraine. MAIN OUTCOMES AND MEASURES: Frequency of migraine and its subtypes in patients with CEAD IS vs non-CEAD IS. RESULTS: Of the 2485 patients (mean [SD] age, 36.8 [7.1] years; women, 1163 [46.8%]) included in the registry, 334 (13.4%) had CEAD IS and 2151 (86.6%) had non-CEAD IS. Migraine was more common in the CEAD IS group (103 [30.8%] vs 525 [24.4%], P = .01), and the difference was mainly due to migraine without aura (80 [24.0%] vs 335 [15.6%], P < .001). Compared with migraine with aura, migraine without aura was independently associated with CEAD IS (OR, 1.74; 95% CI, 1.30-2.33). The strength of this association was higher in men (OR, 1.99; 95% CI, 1.31-3.04) and in patients 39.0 years or younger (OR, 1.82; 95% CI, 1.22-2.71). The risk factor profile was similar in migrainous and non-migrainous patients with CEAD IS (eg, hypertension, 20 [19.4%] vs 57 [24.7%], P = .29; diabetes, 1 [1.0%] vs 3 [1.3%], P > .99). CONCLUSIONS AND RELEVANCE: In patients with IS aged 18 to 45 years, migraine, especially migraine without aura, is consistently associated with CEAD. This finding suggests common features and warrants further analyses to elucidate the underlying biologic mechanisms.

Published
2017
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24. Severe polyneuropathy in a patient with Churg‐Strauss syndrome

Author

Bazzi, Paola, primary, Tancredi, Lucia, additional, Scarpini, Elio, additional, Messina, Stefano, additional, Sciacco, Monica, additional, Livraghi, Simona, additional, Vanoli, Massimo, additional, Prelle, Alessandro, additional, Scarlato, Guglielmo, additional, and Moggio, Maurizio, additional

Published
2000
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25. Clinical pregenetic screening for stroke monogenic diseases: Results from lombardia GENS registry

Author

Giorgio Bono, Eloisa Arbustini, Patrizia Perrone, Silvia Baratta, Graziella Molini, Elena Pinuccia Verrengia, Massimiliano Braga, Manuel Corato, Erminio Capitani, Gaetano S. Grieco, Pierluigi Baron, Giampaolo Merlini, Simona Marcheselli, Giuseppe Micieli, Nadia Trobia, Davide Uccellini, Anna Cavallini, Elio Agostoni, Mario Guidotti, Carlo Ferrarese, Alessandro Padovani, Laura Fusi, Caspar Grond-Ginsbach, Giacomo P. Comi, Silvia Lanfranconi, Marco Arnaboldi, Barbara Incorvaia, Livia Candelise, Maria Teresa Bassi, Cristina Motto, Paola Carrera, Lorena Mosca, Nicoletta Checcarelli, Lucia Tancredi, Alessando Pezzini, Hugh S. Markus, Laura Obici, Giancarlo Comi, Bianca Maria Bordo, Maria Luisa De Lodovici, Giorgio B. Boncoraglio, Davide Zarcone, Maurizia Grasso, Dario Ronchi, Maria Sessa, Francesca Mazucchelli, Maria Vittoria Calloni, Stefania Corti, Francesco Sasanelli, Paolo Vitali, Giampiero Grampa, C. Gellera, Maurizio Ferrari, Cristina Cereda, Antonio Colombo, Silvana Penco, Anna Bersano, Franco Taroni, Simone Beretta, Carlo Sebastiano Tadeo, Silvana Quaglini, Eugenio Parati, Bersano, A, Markus, H, Quaglini, S, Arbustini, E, Lanfranconi, S, Micieli, G, Boncoraglio, G, Taroni, F, Gellera, C, Baratta, S, Penco, S, Mosca, L, Grasso, M, Carrera, P, Ferrari, M, Cereda, C, Grieco, G, Corti, S, Ronchi, D, Bassi, M, Obici, L, Parati, E, Pezzini, A, De Lodovici, M, Verrengia, E, Bono, G, Mazucchelli, F, Zarcone, D, Calloni, M, Perrone, P, Bordo, B, Colombo, A, Padovani, A, Cavallini, A, Beretta, S, Ferrarese, C, Motto, C, Agostoni, E, Molini, G, Sasanelli, F, Corato, M, Marcheselli, S, Sessa, M, Comi, G, Checcarelli, N, Guidotti, M, Uccellini, D, Capitani, E, Tancredi, L, Arnaboldi, M, Incorvaia, B, Tadeo, C, Fusi, L, Grampa, G, Merlini, G, Trobia, N, Braga, M, Vitali, P, Baron, P, Grond Ginsbach, C, Candelise, L, Bersano, Anna, Markus, Hugh Stephen, Quaglini, Silvana, Arbustini, Eloisa, Lanfranconi, Silvia, Micieli, Giuseppe, Boncoraglio, Giorgio B., Taroni, Franco, Gellera, Cinzia, Baratta, Silvia, Penco, Silvana, Mosca, Lorena, Grasso, Maurizia, Carrera, Paola, Ferrari, Maurizio, Cereda, Cristina, Grieco, Gaetano, Corti, Stefania, Ronchi, Dario, Bassi, Maria Teresa, Obici, Laura, Parati, Eugenio A., Pezzini, Alessando, De Lodovici, Maria Luisa, Verrengia, Elena P., Bono, Giorgio, Mazucchelli, Francesca, Zarcone, Davide, Calloni, Maria Vittoria, Perrone, Patrizia, Bordo, Bianca Maria, Colombo, Antonio, Padovani, Alessandro, Cavallini, Anna, Beretta, Simone, Ferrarese, Carlo, Motto, Cristina, Agostoni, Elio, Molini, Graziella, Sasanelli, Francesco, Corato, Manuel, Marcheselli, Simona, Sessa, Maria, Comi, Giancarlo, Checcarelli, Nicoletta, Guidotti, Mario, Uccellini, Davide, Capitani, Erminio, Tancredi, Lucia, Arnaboldi, Marco, Incorvaia, Barbara, Tadeo, Carlo Sebastiano, Fusi, Laura, Grampa, Giampiero, Merlini, Giampaolo, Trobia, Nadia, Comi, Giacomo Pietro, Braga, Massimiliano, Vitali, Paolo, Baron, Pierluigi, Grond Ginsbach, Caspar, and Candelise, Livia

Subjects
Adult, Male, Mitochondrial encephalomyopathy, Pediatrics, medicine.medical_specialty, Pathology, DNA Mutational Analysis, CADASIL, Disease, 030204 cardiovascular system & hematology, MELAS syndrome, Leukoencephalopathy, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, genetics, Genetic Testing, Registries, Stroke, cerebral amyloid angiopathy, Aged, Genetic testing, Advanced and Specialized Nursing, Fabry disease, medicine.diagnostic_test, business.industry, cerebral amyloid angiopathy, familial, Marfan syndrome, stroke, Neurology (clinical), Cardiology and Cardiovascular Medicine, familial, Middle Aged, medicine.disease, Mutation, Female, genetic, business, 030217 neurology & neurosurgery
Abstract

Background and Purpose— Lombardia GENS is a multicentre prospective study aimed at diagnosing 5 single-gene disorders associated with stroke (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, Fabry disease, MELAS [mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes], hereditary cerebral amyloid angiopathy, and Marfan syndrome) by applying diagnostic algorithms specific for each clinically suspected disease Methods— We enrolled a consecutive series of patients with ischemic or hemorrhagic stroke or transient ischemic attack admitted in stroke units in the Lombardia region participating in the project. Patients were defined as probable when presenting with stroke or transient ischemic attack of unknown etiopathogenic causes, or in the presence of Results— In 209 patients (57.4±14.7 years), the application of the disease-specific algorithm identified 227 patients with possible monogenic disease. Genetic testing identified pathogenic mutations in 7% of these cases. Familial history of stroke was the only significant specific feature that distinguished mutated patients from nonmutated ones. The presence of cerebrovascular risk factors did not exclude a genetic disease. Conclusions— In patients prescreened using a clinical algorithm for monogenic disorders, we identified monogenic causes of events in 7% of patients in comparison to the 1% to 5% prevalence reported in previous series.

Published
2016

26. Incidence and Long-term Functional Outcome of Neurologic Disorders in Hospitalized Patients With COVID-19 Infected With Pre-Omicron Variants.

Author

Beretta S, Cristillo V, Camera G, Morotti Colleoni C, Pellitteri G, Viti B, Bianchi E, Gipponi S, Grimoldi M, Valente M, Guttmann S, Cotelli MS, Palumbo P, Gelosa G, Meletti S, Schenone C, Ottaviani D, Filippi M, Zini A, Basilico P, Tancredi L, Cortelli P, Braga M, De Giuli V, Servidei S, Paolicelli D, Verde F, Caproni S, Pisani A, Lo Re V, Massacesi L, Roccatagliata DV, Manganotti P, Spitaleri D, Formenti A, Piccioli M, Marino S, Polverino P, Aguglia U, Ornello R, Perego E, Siciliano G, Merlo P, Capobianco M, Pantoni L, Lugaresi A, Angelocola S, De Rosa A, Sessa M, Beghi E, Agostoni EC, Monaco S, Padovani A, Priori A, Silani V, Tedeschi G, and Ferrarese C

Subjects
Humans, Cohort Studies, Incidence, Prospective Studies, SARS-CoV-2, Ischemic Stroke, COVID-19 complications, Nervous System Diseases epidemiology, Stroke epidemiology
Abstract

Background and Objectives: A variety of neurologic disorders have been reported as presentations or complications of coronavirus disease 2019 (COVID-19) infection. The objective of this study was to determine their incidence dynamics and long-term functional outcome., Methods: The Neuro-COVID Italy study was a multicenter, observational, cohort study with ambispective recruitment and prospective follow-up. Consecutive hospitalized patients presenting new neurologic disorders associated with COVID-19 infection (neuro-COVID), independently from respiratory severity, were systematically screened and actively recruited by neurology specialists in 38 centers in Italy and the Republic of San Marino. The primary outcomes were incidence of neuro-COVID cases during the first 70 weeks of the pandemic (March 2020-June 2021) and long-term functional outcome at 6 months, categorized as full recovery, mild symptoms, disabling symptoms, or death., Results: Among 52,759 hospitalized patients with COVID-19, 1,865 patients presenting 2,881 new neurologic disorders associated with COVID-19 infection (neuro-COVID) were recruited. The incidence of neuro-COVID cases significantly declined over time, comparing the first 3 pandemic waves (8.4%, 95% CI 7.9-8.9; 5.0%, 95% CI 4.7-5.3; 3.3%, 95% CI 3.0-3.6, respectively; p = 0.027). The most frequent neurologic disorders were acute encephalopathy (25.2%), hyposmia-hypogeusia (20.2%), acute ischemic stroke (18.4%), and cognitive impairment (13.7%). The onset of neurologic disorders was more common in the prodromic phase (44.3%) or during the acute respiratory illness (40.9%), except for cognitive impairment whose onset prevailed during recovery (48.4%). A good functional outcome was achieved by most patients with neuro-COVID (64.6%) during follow-up (median 6.7 months), and the proportion of good outcome increased throughout the study period ( r = 0.29, 95% CI 0.05-0.50; p = 0.019). Mild residual symptoms were frequently reported (28.1%) while disabling symptoms were common only in stroke survivors (47.6%)., Discussion: Incidence of COVID-associated neurologic disorders decreased during the prevaccination phase of the pandemic. Long-term functional outcome was favorable in most neuro-COVID disorders, although mild symptoms commonly lasted more than 6 months after infection., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.)

Published
2023
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27. Migraine and Cryptogenic Ischemic Stroke.

Author

Mazzoleni V, Grassi M, Lodigiani C, Rasura M, Zedde M, Gandolfo C, Zini A, DeLodovici ML, Paciaroni M, Del Sette M, Toriello A, Musolino R, Calabrò RS, Bovi P, Giossi A, Adami A, Silvestrelli G, Cavallini A, Marcheselli S, Bonifati DM, Checcarelli N, Tancredi L, Chiti A, Giorli E, Pezzini D, Locatelli M, Bonacina S, Giacalone G, Volta GD, Magoni M, Cerrato P, Bignamini V, Micieli G, Melis M, Sanguigni S, Braga M, Padovani A, and Pezzini A

Subjects
Humans, Young Adult, Brain Ischemia complications, Foramen Ovale, Patent, Ischemic Stroke, Migraine Disorders, Stroke epidemiology, Stroke etiology
Published
2021
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28. History of Migraine and Volume of Brain Infarcts: The Italian Project on Stroke at Young Age (IPSYS).

Author

De Giuli V, Besana M, Grassi M, Zedde M, Zini A, Lodigiani C, Marcheselli S, Cavallini A, Micieli G, Rasura M, DeLodovici ML, Tomelleri G, Checcarelli N, Chiti A, Giorli E, Sette MD, Tancredi L, Toriello A, Braga M, Morotti A, Poli L, Caria F, Gamba M, Patella R, Spalloni A, Simone AM, Pascarella R, Beretta S, Fainardi E, Padovani A, Gasparotti R, and Pezzini A

Abstract

Background and Purpose: Migraine has been shown to increase cerebral excitability, promote rapid infarct expansion into tissue with perfusion deficits, and result in larger infarcts in animal models of focal cerebral ischemia. Whether these effects occur in humans has never been properly investigated., Methods: In a series of consecutive patients with acute ischemic stroke, enrolled in the setting of the Italian Project on Stroke at Young Age, we assessed acute as well as chronic infarct volumes by volumetric magnetic resonance imaging, and compared these among different subgroups identified by migraine status., Results: A cohort of 591 patients (male, 53.8%; mean age, 37.5±6.4 years) qualified for the analysis. Migraineurs had larger acute infarcts than non-migraineurs (median, 5.9 cm3 [interquartile range (IQR), 1.4 to 15.5] vs. 2.6 cm3 [IQR, 0.8 to 10.1], P<0.001), and the largest volumes were observed in patients with migraine with aura (median, 9.0 cm3 [IQR, 3.4 to 16.6]). In a linear regression model, migraine was an independent predictor of increased log (acute infarct volumes) (median ratio [MR], 1.64; 95% confidence interval [CI], 1.22 to 2.20), an effect that was more prominent for migraine with aura (MR, 2.92; 95% CI, 1.88 to 4.54)., Conclusion: s These findings reinforce the experimental observation of larger acute cerebral infarcts in migraineurs, extend animal data to human disease, and support the hypothesis of increased vulnerability to ischemic brain injury in people suffering migraine.

Published
2019
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