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3. IMPACT-Global Hip Fracture Audit: Nosocomial infection, risk prediction and prognostication, minimum reporting standards and global collaborative audit. Lessons from an international multicentre study of 7,090 patients conducted in 14 nations during the COVID-19 pandemic

Author

Hall, A, Clement, N, Ojeda-Thies, C, Maclullich, A, Toro, G, Johansen, A, White, T, Duckworth, A, Abdul-Jabar, H, Abu-Rajab, R, Abugarja, A, Adam, K, Aguado Hernández, H, Améstica Lazcano, G, Anderson, S, Ansar, M, Antrobus, J, Aragón Achig, E, Archunan, M, Arrieta Salinas, M, Ashford-Wilson, S, Assens Gibert, C, Athanasopoulou, K, Awadelkarim, M, Baird, S, Bajada, S, Balakrishnan, S, Balasubramanian, S, Ballantyne, J, Bárcena Goitiandia, L, Barkham, B, Barmpagianni, C, Barres-Carsi, M, Barrett, S, Baskaran, D, Bell, J, Bell, K, Bell, S, Bellelli, G, Benchimol, J, Boietti, B, Boswell, S, Braile, A, Brennan, C, Brent, L, Brooke, B, Bruno, G, Burahee, A, Burns, S, Calabrò, G, Campbell, L, Carabelli, G, Carnegie, C, Carretero Cristobal, G, Caruana, E, Cassinello Ogea, M, Castellanos Robles, J, Castillon, P, Chakrabarti, A, Cecere, A, Chen, P, Clarke, J, Collins, G, Corrales Cardenal, J, Corsi, M, Cózar Adelantado, G, Craxford, S, Crooks, M, Cuarental-García, J, Cuthbert, R, Dall, G, Daskalakis, I, De Cicco, A, Diana, D, Demaria, P, Dereix, J, Díaz Jiménez, J, Dinamarca Montecinos, J, Do Le, H, Donoso Coppa, J, Drosos, G, Duffy, A, East, J, Eastwood, D, Elbahari, H, Elias de Molins Peña, C, Elmamoun, M, Emmerson, B, Escobar Sánchez, D, Faimali, M, Farré-Mercadé, M, Farrow, L, Fayez, A, Fell, A, Fenner, C, Ferguson, D, Finlayson, L, Flores Gómez, A, Freeman, N, French, J, Gabardo Calvo, S, Gagliardo, N, Garcia Albiñana, J, García Cruz, G, García de Cortázar Antolín, U, García Virto, V, Gealy, S, Gil Caballero, S, Gill, M, González González, M, Gopireddy, R, Guntley, D, Gurung, B, Guzmán Rosales, G, Haddad, N, Hafeez, M, Haller, P, Halligan, E, Hardie, J, Hawker, I, Helal, A, Herrera Cruz, M, Herreros Ruiz-Valdepeñas, R, Horton, J, Howells, S, Howieson, A, Hughes, L, Hünicken Torrez, F, Hurtado Ortega, A, Huxley, P, Hamid, H, Ilahi, N, Iliadis, A, Inman, D, Jadhao, P, Jandoo, R, Jawad, L, Jayatilaka, M, Jenkins, P, Jeyapalan, R, Johnson, D, Johnston, A, Joseph, S, Kapoor, S, Karagiannidis, G, Karanam, K, Kattakayam, F, Konarski, A, Kontakis, G, Labrador Hernández, G, Lancaster, V, Landi, G, Le, B, Liew, I, Logishetty, K, Lopez Marquez, A, Lopez, J, Lum, J, Macpherson, G, Madan, S, Mahroof, S, Malik-Tabassum, K, Mallina, R, Maqsood, A, Marson, B, Martin Legorburo, M, Martin-Perez, E, Martínez Jiménez, T, Martinez Martin, J, Mayne, A, Mayor, A, Mcalinden, G, Mclean, L, Mcdonald, L, Mcintyre, J, Mckay, P, Mckean, G, Mcshane, H, Medici, A, Meeke, C, Meldrum, E, Mendez, M, Mercer, S, Merino Perez, J, Mesa-Lampré, M, Mighton, S, Milne, K, Mohamed Yaseen, M, Moppett, I, Mora, J, Morales-Zumel, S, Moreno Fenoll, I, Mousa, A, Murray, A, Murray, E, Nair, R, Neary, F, Negri, G, Negus, O, Newham-Harvey, F, Ng, N, Nightingale, J, Noor Mohamed Anver, S, Nunag, P, O'Hare, M, Ollivere, B, Ortés Gómez, R, Owens, A, Page, S, Palloni, V, Panagiotopoulos, A, Panagiotopoulos, E, Panesar, P, Papadopoulos, A, Spyridon, P, Pareja Sierra, T, Park, C, Parwaiz, H, Paterson-Byrne, P, Patton, S, Pearce, J, Porter, M, Pellegrino, A, Pèrez Cuellar, A, Pezzella, R, Phadnis, A, Pinder, C, Piper, D, Powell-Bowns, M, Prieto Martín, R, Probert, A, Ramesh, A, Ramírez de Arellano, M, Renton, D, Rickman, S, Robertson, A, Roche Albero, A, Rodrigo Verguizas, J, Rodríguez Couso, M, Rooney, J, Sáez-López, P, Saldaña-Díaz, A, Santulli, A, Sanz Pérez, M, Sarraf, K, Scarsbrook, C, Scott, C, Scott, J, Shah, S, Sharaf, S, Sharma, S, Shirley, D, Siano, A, Simpson, J, Singh, A, Sinnett, T, Sisodia, G, Smith, P, Sophena Bert, E, Steel, M, Stewart, A, Stewart, C, Sugand, K, Sullivan, N, Sweeting, L, Symes, M, Tan, D, Tancredi, F, Tatani, I, Thomas, P, Thomson, F, Toner, N, Tong, A, Toro, A, Tosounidis, T, Tottas, S, Trinidad Leo, A, Tucker, D, Vemulapalli, K, Ventura Garces, D, Vernon, O, Viveros Garcia, J, Ward, A, Ward, K, Watson, K, Weerasuriya, T, Wickramanayake, U, Wilkinson, H, Windley, J, Wood, J, Wynell-Mayow, W, Zatti, G, Zeiton, M, Zurrón Lobato, M, Hall, Andrew J., Clement, Nicholas D., Ojeda-Thies, Cristina, MacLullich, Alasdair MJ., Toro, Giuseppe, Johansen, Antony, White, Tim O., Duckworth, Andrew D., Abdul-Jabar, Hani, Abu-Rajab, Rashid, Abugarja, Ahmed, Adam, Karen, Aguado Hernández, Héctor J., Améstica Lazcano, Gedeón, Anderson, Sarah, Ansar, Mahmood, Antrobus, Jonathan, Aragón Achig, Esteban Javier, Archunan, Maheswaran, Arrieta Salinas, Mirentxu, Ashford-Wilson, Sarah, Assens Gibert, Cristina, Athanasopoulou, Katerina, Awadelkarim, Mohamed, Baird, Stuart, Bajada, Stefan, Balakrishnan, Shobana, Balasubramanian, Sathishkumar, Ballantyne, James A., Bárcena Goitiandia, Leopoldo, Barkham, Benjamin, Barmpagianni, Christina, Barres-Carsi, Mariano, Barrett, Sarah, Baskaran, Dinnish, Bell, Jean, Bell, Katrina, Bell, Stuart, Bellelli, Giuseppe, Benchimol, Javier Alberto, Boietti, Bruno Rafael, Boswell, Sally, Braile, Adriano, Brennan, Caitlin, Brent, Louise, Brooke, Ben, Bruno, Gaetano, Burahee, Abdus, Burns, Shirley, Calabrò, Giampiero, Campbell, Lucy, Carabelli, Guido Sebastian, Carnegie, Carol, Carretero Cristobal, Guillermo, Caruana, Ethan, Cassinello Ogea, M. a Concepción, Castellanos Robles, Juan, Castillon, Pablo, Chakrabarti, Anil, Cecere, Antonio Benedetto, Chen, Ping, Clarke, Jon V., Collins, Grace, Corrales Cardenal, Jorge E., Corsi, Maurizio, Cózar Adelantado, Gara María, Craxford, Simon, Crooks, Melissa, Cuarental-García, Javier, Cuthbert, Rory, Dall, Graham, Daskalakis, Ioannis, De Cicco, Annalisa, Diana, de la Fuente de Dios, Demaria, Pablo, Dereix, John, Díaz Jiménez, Julian, Dinamarca Montecinos, José Luis, Do Le, Ha Phuong, Donoso Coppa, Juan Pablo, Drosos, Georgios, Duffy, Andrew, East, Jamie, Eastwood, Deborah, Elbahari, Hassan, Elias de Molins Peña, Carmen, Elmamoun, Mamoun, Emmerson, Ben, Escobar Sánchez, Daniel, Faimali, Martina, Farré-Mercadé, Maria Victòria, Farrow, Luke, Fayez, Almari, Fell, Adam, Fenner, Christopher, Ferguson, David, Finlayson, Louise, Flores Gómez, Aldo, Freeman, Nicholas, French, Jonathan, Gabardo Calvo, Santiago, Gagliardo, Nicola, Garcia Albiñana, Joan, García Cruz, Guillermo, García de Cortázar Antolín, Unai, García Virto, Virginia, Gealy, Sophie, Gil Caballero, Sandra Marcela, Gill, Moneet, González González, María Soledad, Gopireddy, Rajesh, Guntley, Diane, Gurung, Binay, Guzmán Rosales, Guadalupe, Haddad, Nedaa, Hafeez, Mahum, Haller, Petra, Halligan, Emer, Hardie, John, Hawker, Imogen, Helal, Amr, Herrera Cruz, Mariana, Herreros Ruiz-Valdepeñas, Ruben, Horton, James, Howells, Sean, Howieson, Alan, Hughes, Luke, Hünicken Torrez, Flavia Lorena, Hurtado Ortega, Ana, Huxley, Peter, Hamid, Hytham K. S., Ilahi, Nida, Iliadis, Alexis, Inman, Dominic, Jadhao, Piyush, Jandoo, Rajan, Jawad, Lucy, Jayatilaka, Malwattage Lara Tania, Jenkins, Paul J., Jeyapalan, Rathan, Johnson, David, Johnston, Andrew, Joseph, Sarah, Kapoor, Siddhant, Karagiannidis, Georgios, Karanam, Krishna Saga, Kattakayam, Freddy, Konarski, Alastair, Kontakis, Georgios, Labrador Hernández, Gregorio, Lancaster, Victoria, Landi, Giovanni, Le, Brian, Liew, Ignatius, Logishetty, Kartik, Lopez Marquez, Andrew Carlomaria Daniel, Lopez, Judit, Lum, Joann, Macpherson, Gavin J., Madan, Suvira, Mahroof, Sabreena, Malik-Tabassum, Khalid, Mallina, Ravi, Maqsood, Afnan, Marson, Ben, Martin Legorburo, M José, Martin-Perez, Encarna, Martínez Jiménez, Tania, Martinez Martin, Javier, Mayne, Alistair, Mayor, Amy, McAlinden, Gavan, McLean, Lucille, McDonald, Lorna, McIntyre, Joshua, McKay, Pamela, McKean, Greg, McShane, Heather, Medici, Antonio, Meeke, Chelsea, Meldrum, Evonne, Mendez, Mijail, Mercer, Scott, Merino Perez, Josu, Mesa-Lampré, María-Pilar, Mighton, Shuna, Milne, Kirsty, Mohamed Yaseen, Muhammed, Moppett, Iain, Mora, Jesus, Morales-Zumel, Sira, Moreno Fenoll, Irene Blanca, Mousa, Adham, Murray, Alastair W., Murray, Elspeth V., Nair, Radhika, Neary, Fiona, Negri, Giacomo, Negus, Oliver, Newham-Harvey, Fiona, Ng, Nigel, Nightingale, Jess, Noor Mohamed Anver, Sumiya, Nunag, Perrico, O'Hare, Matthew, Ollivere, Ben, Ortés Gómez, Raquel, Owens, AnneMarie, Page, Siobhan, Palloni, Valentina, Panagiotopoulos, Andreas, Panagiotopoulos, Elias, Panesar, Paul, Papadopoulos, Antonios, Spyridon, Papagiannis, Pareja Sierra, Teresa, Park, Chang, Parwaiz, Hammad, Paterson-Byrne, Paul, Patton, Sam, Pearce, Jack, Porter, Marina, Pellegrino, Achille, Pèrez Cuellar, Arturo, Pezzella, Raffaele, Phadnis, Ashish, Pinder, Charlotte, Piper, Danielle, Powell-Bowns, Matilda, Prieto Martín, Rocío, Probert, Annabel, Ramesh, Ashwanth, Ramírez de Arellano, Manuel Vicente Mejía, Renton, Duncan, Rickman, Stephen, Robertson, Alastair, Roche Albero, Adrian, Rodrigo Verguizas, José Alberto, Rodríguez Couso, Myriam, Rooney, Joanna, Sáez-López, Pilar, Saldaña-Díaz, Andres, Santulli, Adriano, Sanz Pérez, Marta Isabel, Sarraf, Khaled M., Scarsbrook, Christine, Scott, Chloe E. H., Scott, Jennifer, Shah, Sachi, Sharaf, Sharief, Sharma, Sidharth, Shirley, Denise, Siano, Antonio, Simpson, James, Singh, Abhinav, Singh, Amit, Sinnett, Tim, Sisodia, Gurudatt, Smith, Philomena, Sophena Bert, Eugenia, Steel, Michael, Stewart, Avril, Stewart, Claire, Sugand, Kapil, Sullivan, Niall, Sweeting, Lauren, Symes, Michael, Tan, Dylan Jun Hao, Tancredi, Francesco, Tatani, Irini, Thomas, Philip, Thomson, Fraser, Toner, Niamh S., Tong, Anna, Toro, Antonio, Tosounidis, Theodoros, Tottas, Stylianos, Trinidad Leo, Andrea, Tucker, Damien, Vemulapalli, Krishna, Ventura Garces, Diego, Vernon, Olivia Katherine, Viveros Garcia, Juan Carlos, Ward, Alex, Ward, Kirsty, Watson, Kate, Weerasuriya, Thisara, Wickramanayake, Udara, Wilkinson, Hannah, Windley, Joseph, Wood, Janet, Wynell-Mayow, William, Zatti, Giovanni, Zeiton, Moez, Zurrón Lobato, Miriam, Hall, A, Clement, N, Ojeda-Thies, C, Maclullich, A, Toro, G, Johansen, A, White, T, Duckworth, A, Abdul-Jabar, H, Abu-Rajab, R, Abugarja, A, Adam, K, Aguado Hernández, H, Améstica Lazcano, G, Anderson, S, Ansar, M, Antrobus, J, Aragón Achig, E, Archunan, M, Arrieta Salinas, M, Ashford-Wilson, S, Assens Gibert, C, Athanasopoulou, K, Awadelkarim, M, Baird, S, Bajada, S, Balakrishnan, S, Balasubramanian, S, Ballantyne, J, Bárcena Goitiandia, L, Barkham, B, Barmpagianni, C, Barres-Carsi, M, Barrett, S, Baskaran, D, Bell, J, Bell, K, Bell, S, Bellelli, G, Benchimol, J, Boietti, B, Boswell, S, Braile, A, Brennan, C, Brent, L, Brooke, B, Bruno, G, Burahee, A, Burns, S, Calabrò, G, Campbell, L, Carabelli, G, Carnegie, C, Carretero Cristobal, G, Caruana, E, Cassinello Ogea, M, Castellanos Robles, J, Castillon, P, Chakrabarti, A, Cecere, A, Chen, P, Clarke, J, Collins, G, Corrales Cardenal, J, Corsi, M, Cózar Adelantado, G, Craxford, S, Crooks, M, Cuarental-García, J, Cuthbert, R, Dall, G, Daskalakis, I, De Cicco, A, Diana, D, Demaria, P, Dereix, J, Díaz Jiménez, J, Dinamarca Montecinos, J, Do Le, H, Donoso Coppa, J, Drosos, G, Duffy, A, East, J, Eastwood, D, Elbahari, H, Elias de Molins Peña, C, Elmamoun, M, Emmerson, B, Escobar Sánchez, D, Faimali, M, Farré-Mercadé, M, Farrow, L, Fayez, A, Fell, A, Fenner, C, Ferguson, D, Finlayson, L, Flores Gómez, A, Freeman, N, French, J, Gabardo Calvo, S, Gagliardo, N, Garcia Albiñana, J, García Cruz, G, García de Cortázar Antolín, U, García Virto, V, Gealy, S, Gil Caballero, S, Gill, M, González González, M, Gopireddy, R, Guntley, D, Gurung, B, Guzmán Rosales, G, Haddad, N, Hafeez, M, Haller, P, Halligan, E, Hardie, J, Hawker, I, Helal, A, Herrera Cruz, M, Herreros Ruiz-Valdepeñas, R, Horton, J, Howells, S, Howieson, A, Hughes, L, Hünicken Torrez, F, Hurtado Ortega, A, Huxley, P, Hamid, H, Ilahi, N, Iliadis, A, Inman, D, Jadhao, P, Jandoo, R, Jawad, L, Jayatilaka, M, Jenkins, P, Jeyapalan, R, Johnson, D, Johnston, A, Joseph, S, Kapoor, S, Karagiannidis, G, Karanam, K, Kattakayam, F, Konarski, A, Kontakis, G, Labrador Hernández, G, Lancaster, V, Landi, G, Le, B, Liew, I, Logishetty, K, Lopez Marquez, A, Lopez, J, Lum, J, Macpherson, G, Madan, S, Mahroof, S, Malik-Tabassum, K, Mallina, R, Maqsood, A, Marson, B, Martin Legorburo, M, Martin-Perez, E, Martínez Jiménez, T, Martinez Martin, J, Mayne, A, Mayor, A, Mcalinden, G, Mclean, L, Mcdonald, L, Mcintyre, J, Mckay, P, Mckean, G, Mcshane, H, Medici, A, Meeke, C, Meldrum, E, Mendez, M, Mercer, S, Merino Perez, J, Mesa-Lampré, M, Mighton, S, Milne, K, Mohamed Yaseen, M, Moppett, I, Mora, J, Morales-Zumel, S, Moreno Fenoll, I, Mousa, A, Murray, A, Murray, E, Nair, R, Neary, F, Negri, G, Negus, O, Newham-Harvey, F, Ng, N, Nightingale, J, Noor Mohamed Anver, S, Nunag, P, O'Hare, M, Ollivere, B, Ortés Gómez, R, Owens, A, Page, S, Palloni, V, Panagiotopoulos, A, Panagiotopoulos, E, Panesar, P, Papadopoulos, A, Spyridon, P, Pareja Sierra, T, Park, C, Parwaiz, H, Paterson-Byrne, P, Patton, S, Pearce, J, Porter, M, Pellegrino, A, Pèrez Cuellar, A, Pezzella, R, Phadnis, A, Pinder, C, Piper, D, Powell-Bowns, M, Prieto Martín, R, Probert, A, Ramesh, A, Ramírez de Arellano, M, Renton, D, Rickman, S, Robertson, A, Roche Albero, A, Rodrigo Verguizas, J, Rodríguez Couso, M, Rooney, J, Sáez-López, P, Saldaña-Díaz, A, Santulli, A, Sanz Pérez, M, Sarraf, K, Scarsbrook, C, Scott, C, Scott, J, Shah, S, Sharaf, S, Sharma, S, Shirley, D, Siano, A, Simpson, J, Singh, A, Sinnett, T, Sisodia, G, Smith, P, Sophena Bert, E, Steel, M, Stewart, A, Stewart, C, Sugand, K, Sullivan, N, Sweeting, L, Symes, M, Tan, D, Tancredi, F, Tatani, I, Thomas, P, Thomson, F, Toner, N, Tong, A, Toro, A, Tosounidis, T, Tottas, S, Trinidad Leo, A, Tucker, D, Vemulapalli, K, Ventura Garces, D, Vernon, O, Viveros Garcia, J, Ward, A, Ward, K, Watson, K, Weerasuriya, T, Wickramanayake, U, Wilkinson, H, Windley, J, Wood, J, Wynell-Mayow, W, Zatti, G, Zeiton, M, Zurrón Lobato, M, Hall, Andrew J., Clement, Nicholas D., Ojeda-Thies, Cristina, MacLullich, Alasdair MJ., Toro, Giuseppe, Johansen, Antony, White, Tim O., Duckworth, Andrew D., Abdul-Jabar, Hani, Abu-Rajab, Rashid, Abugarja, Ahmed, Adam, Karen, Aguado Hernández, Héctor J., Améstica Lazcano, Gedeón, Anderson, Sarah, Ansar, Mahmood, Antrobus, Jonathan, Aragón Achig, Esteban Javier, Archunan, Maheswaran, Arrieta Salinas, Mirentxu, Ashford-Wilson, Sarah, Assens Gibert, Cristina, Athanasopoulou, Katerina, Awadelkarim, Mohamed, Baird, Stuart, Bajada, Stefan, Balakrishnan, Shobana, Balasubramanian, Sathishkumar, Ballantyne, James A., Bárcena Goitiandia, Leopoldo, Barkham, Benjamin, Barmpagianni, Christina, Barres-Carsi, Mariano, Barrett, Sarah, Baskaran, Dinnish, Bell, Jean, Bell, Katrina, Bell, Stuart, Bellelli, Giuseppe, Benchimol, Javier Alberto, Boietti, Bruno Rafael, Boswell, Sally, Braile, Adriano, Brennan, Caitlin, Brent, Louise, Brooke, Ben, Bruno, Gaetano, Burahee, Abdus, Burns, Shirley, Calabrò, Giampiero, Campbell, Lucy, Carabelli, Guido Sebastian, Carnegie, Carol, Carretero Cristobal, Guillermo, Caruana, Ethan, Cassinello Ogea, M. a Concepción, Castellanos Robles, Juan, Castillon, Pablo, Chakrabarti, Anil, Cecere, Antonio Benedetto, Chen, Ping, Clarke, Jon V., Collins, Grace, Corrales Cardenal, Jorge E., Corsi, Maurizio, Cózar Adelantado, Gara María, Craxford, Simon, Crooks, Melissa, Cuarental-García, Javier, Cuthbert, Rory, Dall, Graham, Daskalakis, Ioannis, De Cicco, Annalisa, Diana, de la Fuente de Dios, Demaria, Pablo, Dereix, John, Díaz Jiménez, Julian, Dinamarca Montecinos, José Luis, Do Le, Ha Phuong, Donoso Coppa, Juan Pablo, Drosos, Georgios, Duffy, Andrew, East, Jamie, Eastwood, Deborah, Elbahari, Hassan, Elias de Molins Peña, Carmen, Elmamoun, Mamoun, Emmerson, Ben, Escobar Sánchez, Daniel, Faimali, Martina, Farré-Mercadé, Maria Victòria, Farrow, Luke, Fayez, Almari, Fell, Adam, Fenner, Christopher, Ferguson, David, Finlayson, Louise, Flores Gómez, Aldo, Freeman, Nicholas, French, Jonathan, Gabardo Calvo, Santiago, Gagliardo, Nicola, Garcia Albiñana, Joan, García Cruz, Guillermo, García de Cortázar Antolín, Unai, García Virto, Virginia, Gealy, Sophie, Gil Caballero, Sandra Marcela, Gill, Moneet, González González, María Soledad, Gopireddy, Rajesh, Guntley, Diane, Gurung, Binay, Guzmán Rosales, Guadalupe, Haddad, Nedaa, Hafeez, Mahum, Haller, Petra, Halligan, Emer, Hardie, John, Hawker, Imogen, Helal, Amr, Herrera Cruz, Mariana, Herreros Ruiz-Valdepeñas, Ruben, Horton, James, Howells, Sean, Howieson, Alan, Hughes, Luke, Hünicken Torrez, Flavia Lorena, Hurtado Ortega, Ana, Huxley, Peter, Hamid, Hytham K. S., Ilahi, Nida, Iliadis, Alexis, Inman, Dominic, Jadhao, Piyush, Jandoo, Rajan, Jawad, Lucy, Jayatilaka, Malwattage Lara Tania, Jenkins, Paul J., Jeyapalan, Rathan, Johnson, David, Johnston, Andrew, Joseph, Sarah, Kapoor, Siddhant, Karagiannidis, Georgios, Karanam, Krishna Saga, Kattakayam, Freddy, Konarski, Alastair, Kontakis, Georgios, Labrador Hernández, Gregorio, Lancaster, Victoria, Landi, Giovanni, Le, Brian, Liew, Ignatius, Logishetty, Kartik, Lopez Marquez, Andrew Carlomaria Daniel, Lopez, Judit, Lum, Joann, Macpherson, Gavin J., Madan, Suvira, Mahroof, Sabreena, Malik-Tabassum, Khalid, Mallina, Ravi, Maqsood, Afnan, Marson, Ben, Martin Legorburo, M José, Martin-Perez, Encarna, Martínez Jiménez, Tania, Martinez Martin, Javier, Mayne, Alistair, Mayor, Amy, McAlinden, Gavan, McLean, Lucille, McDonald, Lorna, McIntyre, Joshua, McKay, Pamela, McKean, Greg, McShane, Heather, Medici, Antonio, Meeke, Chelsea, Meldrum, Evonne, Mendez, Mijail, Mercer, Scott, Merino Perez, Josu, Mesa-Lampré, María-Pilar, Mighton, Shuna, Milne, Kirsty, Mohamed Yaseen, Muhammed, Moppett, Iain, Mora, Jesus, Morales-Zumel, Sira, Moreno Fenoll, Irene Blanca, Mousa, Adham, Murray, Alastair W., Murray, Elspeth V., Nair, Radhika, Neary, Fiona, Negri, Giacomo, Negus, Oliver, Newham-Harvey, Fiona, Ng, Nigel, Nightingale, Jess, Noor Mohamed Anver, Sumiya, Nunag, Perrico, O'Hare, Matthew, Ollivere, Ben, Ortés Gómez, Raquel, Owens, AnneMarie, Page, Siobhan, Palloni, Valentina, Panagiotopoulos, Andreas, Panagiotopoulos, Elias, Panesar, Paul, Papadopoulos, Antonios, Spyridon, Papagiannis, Pareja Sierra, Teresa, Park, Chang, Parwaiz, Hammad, Paterson-Byrne, Paul, Patton, Sam, Pearce, Jack, Porter, Marina, Pellegrino, Achille, Pèrez Cuellar, Arturo, Pezzella, Raffaele, Phadnis, Ashish, Pinder, Charlotte, Piper, Danielle, Powell-Bowns, Matilda, Prieto Martín, Rocío, Probert, Annabel, Ramesh, Ashwanth, Ramírez de Arellano, Manuel Vicente Mejía, Renton, Duncan, Rickman, Stephen, Robertson, Alastair, Roche Albero, Adrian, Rodrigo Verguizas, José Alberto, Rodríguez Couso, Myriam, Rooney, Joanna, Sáez-López, Pilar, Saldaña-Díaz, Andres, Santulli, Adriano, Sanz Pérez, Marta Isabel, Sarraf, Khaled M., Scarsbrook, Christine, Scott, Chloe E. H., Scott, Jennifer, Shah, Sachi, Sharaf, Sharief, Sharma, Sidharth, Shirley, Denise, Siano, Antonio, Simpson, James, Singh, Abhinav, Singh, Amit, Sinnett, Tim, Sisodia, Gurudatt, Smith, Philomena, Sophena Bert, Eugenia, Steel, Michael, Stewart, Avril, Stewart, Claire, Sugand, Kapil, Sullivan, Niall, Sweeting, Lauren, Symes, Michael, Tan, Dylan Jun Hao, Tancredi, Francesco, Tatani, Irini, Thomas, Philip, Thomson, Fraser, Toner, Niamh S., Tong, Anna, Toro, Antonio, Tosounidis, Theodoros, Tottas, Stylianos, Trinidad Leo, Andrea, Tucker, Damien, Vemulapalli, Krishna, Ventura Garces, Diego, Vernon, Olivia Katherine, Viveros Garcia, Juan Carlos, Ward, Alex, Ward, Kirsty, Watson, Kate, Weerasuriya, Thisara, Wickramanayake, Udara, Wilkinson, Hannah, Windley, Joseph, Wood, Janet, Wynell-Mayow, William, Zatti, Giovanni, Zeiton, Moez, and Zurrón Lobato, Miriam

Abstract

Aims: This international study aimed to assess: 1) the prevalence of preoperative and postoperative COVID-19 among patients with hip fracture, 2) the effect on 30-day mortality, and 3) clinical factors associated with the infection and with mortality in COVID-19-positive patients. Methods: A multicentre collaboration among 112 centres in 14 countries collected data on all patients presenting with a hip fracture between 1st March-31st May 2020. Demographics, residence, place of injury, presentation blood tests, Nottingham Hip Fracture Score, time to surgery, management, ASA grade, length of stay, COVID-19 and 30-day mortality status were recorded. Results: A total of 7090 patients were included, with a mean age of 82.2 (range 50–104) years and 4959 (69.9%) being female. Of 651 (9.2%) patients diagnosed with COVID-19, 225 (34.6%) were positive at presentation and 426 (65.4%) were positive postoperatively. Positive COVID-19 status was independently associated with male sex (odds ratio (OR) 1.38, p = 0.001), residential care (OR 2.15, p < 0.001), inpatient fall (OR 2.23, p = 0.003), cancer (OR 0.63, p = 0.009), ASA grades 4 (OR 1.59, p = 0.008) or 5 (OR 8.28, p < 0.001), and longer admission (OR 1.06 for each increasing day, p < 0.001). Patients with COVID-19 at any time had a significantly lower chance of 30-day survival versus those without COVID-19 (72.7% versus 92.6%, p < 0.001). COVID-19 was independently associated with an increased 30-day mortality risk (hazard ratio (HR) 2.83, p < 0.001). Increasing age (HR 1.03, p = 0.028), male sex (HR 2.35, p < 0.001), renal disease (HR 1.53, p = 0.017), and pulmonary disease (HR 1.45, p = 0.039) were independently associated with a higher 30-day mortality risk in patients with COVID-19 when adjusting for confounders. Conclusion: The prevalence of COVID-19 in hip fracture patients during the first wave of the pandemic was 9%, and was independently associated with a three-fold increased 30-day mortality risk.

Published
2022

7. Italian Study on Depressive Disorders (STudio Italiano MAlattia Depressiva, or STIMA-D): a nationwide snapshot of the status of treatment for major depression

Author

Aguglia, E, Biggio, G, Signorelli, Ms, Mencacci, C, Investigators: Aguglia E, Steering Committee on behalf of the STIMA D., Minutolo, G, Altamura, A, Buoli, M, Balestrieri, M, Ciano, R, Amadè, E, Barbera, S, Bellantuono, C, Tofani, S, Bellomo, A, De Salvia ML, Bersani, G, Manuali, G, Bogetto, F, Albert, U, Carpiniello, B, Pinna, F, Ceglie, R, Simonini, E, Clerici, M, D'Urso, N, Di Sciascio, G, Palumbo, C, Fagiolini, A, Goracci, A, Nuvoli, G, Luise, L, Furlan, Pm, Picci, Rl, Guazzelli, M, Janiri, L, Bruschi, A, Barbera, D, Mulè, A, Marchetti, Fp, Corretti, G, Mauri, M, Giunti, I, Mautone, A, Cerruti, C, Sironi, J, Mencarelli, L, Squillacioti, Mr, Nicotera, M, Suffredini, E, Pallanti, S, Cecchelli, C, Placidi, G, Rossi, M, Quartesan, R, Moretti, P, Rabboni, M, Tancredi, F, Rinaudo, C, Roncone, Rita, Malavolta, M, Faletta, O, Avola, V, Scapati, F, Giardina, G, Sciarretta, A, Fonso, T, Starace, F, Viparelli, G, Zeppegno, P, Prosperini, P, Torta, R, Amodeo, L, Venanzini, R, Melchiorre, M, Vender, S, Diurni, M, Verrienti, P, Stoppelli, N, Vita, A, Conte, G, Paradisi, R, Pedrolli, P, Boccara, P, Caselli, A., Aguglia, E, Minutolo, G, Altamura, A, Buoli, M, Balestrieri, M, Ciano, R, Amadè, E, Barbera, S, Bellantuono, C, Tofani, S, Bellomo, A, De Salvia, Ml, Bersani, G, Manuali, G, Bogetto, F, Albert, U, Carpiniello, B, Pinna, F, Ceglie, R, Simonini, E, Clerici, M, D'Urso, N, Di Sciascio, G, Palumbo, C, Fagiolini, A, Goracci, A, Nuvoli, G, Luise, L, Furlan, Pm, Picci, Rl, Guazzelli, M, Janiri, L, Bruschi, A, Barbera, D, Mulè, A, Marchetti, Fp, Corretti, G, Mauri, M, Giunti, I, Mautone, A, Cerruti, C, Mencacci, C, Sironi, J, Mencarelli, L, Squillacioti, Mr, Nicotera, M, Suffredini, E, Pallanti, S, Cecchelli, C, Placidi, G, Rossi, M, Quartesan, R, Moretti, P, Rabboni, M, Tancredi, F, Rinaudo, C, Roncone, R, Malavolta, M, Faletta, O, Avola, V, Scapati, F, Giardina, G, Sciarretta, A, Fonso, T, Starace, F, Viparelli, G, Zeppegno, P, Prosperini, P, Torta, R, Amodeo, L, Venanzini, R, Melchiorre, M, Vender, S, Diurni, M, Verrienti, P, Stoppelli, N, Vita, A, Conte, G, Paradisi, R, Pedrolli, P, Boccara, P, Caselli, A, Aguglia E, Minutolo G, Altamura A, Buoli M, Balestrieri M, Ciano R, Amadè E, Barbera S, Bellantuono C, Tofani S, Bellomo A, De Salvia ML, Bersani G, Manuali G, Bogetto F, Albert U, Carpiniello B, Pinna F, Ceglie R, Simonini E, Clerici M, D'Urso N, Di Sciascio G, Palumbo C, Fagiolini A, Goracci A, Nuvoli G, Luise L, Furlan PM, Picci RL, Guazzelli M, Janiri L, Bruschi A, Barbera D, Mulè A, Marchetti FP, Corretti G, Mauri M, Giunti I, Mautone A, Cerruti C, Mencacci C, Sironi J, Mencarelli L, Squillacioti MR, Nicotera M, Suffredini E, Pallanti S, Cecchelli C, Placidi G, Rossi M, Quartesan R, Moretti P, Rabboni M, Tancredi F, Rinaudo C, Roncone R, Malavolta M, Faletta O, Avola V, Scapati F, Giardina G, Sciarretta A, Fonso T, Starace F, Viparelli G, Zeppegno P, Prosperini P, Torta R, Amodeo L, Venanzini R, Melchiorre M, Vender S, Diurni M, Verrienti P, Stoppelli N, Vita A, Conte G, Paradisi R, Pedrolli P, Boccara P, and Caselli A

Subjects
Male, Pediatrics, Treatment outcome, Patient characteristics, major deression, Adolescent, Adult, Age Factors, Aged, Antidepressive Agents, Depressive Disorder, Major, Female, Humans, Italy, Middle Aged, Physicians, Quality of Life, Serotonin Agents, Young Adult, Treatment Outcome, sideffect, Pharmacology (medical), Young adult, Family history, relapse, General Medicine, Psychiatry and Mental health, antidepressants, Anxiety, epidemiology, Major depression, antidepressants, relapse, side-effects, Adolescent, Adult, Age Factors, Aged, Antidepressive Agents, therapeutic use, Depressive Disorder, Major, drug therapy/epidemiology/psychology, Female, Humans, Italy, epidemiology, Male, Middle Aged, Physicians, psychology, Quality of Life, Serotonin Agents, therapeutic use, Treatment Outcome, Young Adult, medicine.symptom, medicine.medical_specialty, major depression, side-effects, sideffects, psychology, Cost burden, Pharmacotherapy, medicine, Psychiatry, Depressive Disorder, antidepressant, business.industry, antidepressants, major depression, relapse, side-effects, Major depression, Antidepressants, Relapse, Side-effects, medicine.disease, Mood disorders, therapeutic use, drug therapy/epidemiology/psychology, business
Abstract

Introduction: Major depression is a worldwide problem and often remains undetected and untreated. Given the low rates of detection plus the need to intervene in a short time, it is important to identify factors which are likely to improve treatment outcomes. Methods: STIMA-D was designed to provide the profile of patients with major depression in Italy (focusing on pathway to care, patient characteristics, drug therapy and treatment outcomes). The patients enrolled (M/F, aged between 18 and 65) experienced single/multiple episodes of major depression (DSM-IV-TR). Patients with lifetime or current bipolar syndrome or other mental disorders were excluded. Results: 44 of the 50 invited centers sent data concerning 1 140 patients. The majority of patients were women. Among working individuals, 52.5% of them were absent from work due to depression in the previous 6 months. Recurrent episodes of major depression were very common and were associated with persistence of residual post-episodic symptoms, a family history of mood disorders and presence of anxiety. 59.6% of the patients were treated with monotherapy (SSRI or SNRI), while 19.2% of them were treated with SSRI plus SNRI. Only the 25.5% on monotherapy had a complete response compared to 12.4% of patients on dual therapy. Discussion: Poor outcomes in major depression have profound implications on patients’ quality of life and cost burden. New pharmacological approaches with novel modes of action are therefore urgently needed.

Published
2014

9. Air pollution in an urban area nearby the Rome-Ciampino city airport

Author

Di Menno di Bucchianico A, Giorgio Cattani, Gaeta A, Am, Caricchia, Troiano F, Sozzi R, Bolignano A, Sacco F, Damizia S, Barberini S, Caleprico R, Fabozzi T, Ancona C, Ancona L, Cesaroni G, Forastiere F, Gp, Gobbi, Costabile F, Angelini F, Barnaba F, Inglessis M, Tancredi F, Palumbo L, Fontana L, Bergamaschi A, Iavicoli I, Di Menno di Bucchianico, Alessandro, Cattani, Giorgio, Gaeta, Alessandra, Caricchia, Anna Maria, Troiano, Francesco, Sozzi, Roberto, Bolignano, Andrea, Sacco, Fabrizio, Damizia, Sesto, Barberini, Silvia, Caleprico, Roberta, Fabozzi, Tina, Ancona, Carla, Ancona, Laura, Cesaroni, Giulia, Forastiere, Francesco, Gobbi, Gian Paolo, Costabile, Francesca, Angelini, Federico, Barnaba, Francesca, Inglessis, Marco, Tancredi, Francesco, Palumbo, Lorenzo, Fontana, Luca, Bergamaschi, Antonio, and Iavicoli, Ivo

Subjects
Air Pollutants, models, Settore MED/44 - MEDICINA DEL LAVORO, Airports, airport, Air Pollution, Rome, Urban Health, Aiport, air quality, ground measurements
Abstract

OBJECTIVES: to assess air pollution spatial and temporal variability in the urban area nearby the Ciampino International Airport (Rome) and to investigate the airport-related emissions contribute. DESIGN AND SETTING: the study domain was a 64 km2 area around the airport. Two fifteen-day monitoring campaigns (late spring, winter) were carried out. Results were evaluated using several runs outputs of an airport-related sources Lagrangian particle model and a photochemical model (the Flexible Air quality Regional Model, FARM). MAIN OUTCOME MEASURES: both standard and high time resolution air pollutant concentrations measurements: CO, NO, NO2, C6H6, mass and number concentration of several PM fractions. 46 fixed points (spread over the study area) of NO2 and volatile organic compounds concentrations (fifteen days averages); deterministic models outputs. RESULTS: standard time resolution measurements, as well as model outputs, showed the airport contribution to air pollution levels being little compared to the main source in the area (i.e. vehicular traffic). However, using high time resolution measurements, peaks of particles associated with aircraft takeoff (total number concentration and soot mass concentration), and landing (coarse mass concentration) were observed, when the site measurement was downwind to the runway. CONCLUSIONS: the frequently observed transient spikes associated with aircraft movements could lead to a not negligible contribute to ultrafine, soot and coarse particles exposure of people living around the airport. Such contribute and its spatial and temporal variability should be investigated when assessing the airports air quality impact.

Published
2014

10. Active surveillance of Streptococcus pneumoniae bacteremia in Italian children

Author

Tarallo L., Tancredi F., Schito G., Marchese A., Bella A., Manno G., BERNARDI, FILIPPO, MASI, MASSIMO, SPECCHIA, FERNANDO GIUSEPPE, Tarallo L., Tancredi F., Schito G., Marchese A., Bella A., Bernardi F., Masi M., Specchia F., and Manno G.

Subjects
Serotype, Male, medicine.medical_specialty, Databases, Factual, Antimicrobial susceptibility, Bacteremia, Penicillins, medicine.disease_cause, Pneumococcal Infections, Microbiology, Pneumococcal Vaccines, Risk Factors, Internal medicine, Streptococcus pneumoniae, Drug Resistance, Bacterial, Medicine, Humans, Vaccines, Conjugate, General Veterinary, General Immunology and Microbiology, biology, business.industry, Incidence (epidemiology), Public Health, Environmental and Occupational Health, Infant, Newborn, Infant, Streptococcaceae, biology.organism_classification, medicine.disease, Anti-Bacterial Agents, Infectious Diseases, Pneumococcal vaccine, El Niño, Italy, Child, Preschool, Population Surveillance, Molecular Medicine, Female, business
Abstract

There are few data published regarding the incidence of Streptococcus pneumoniae bacteremia in Italian children. A 14-month surveillance study was conducted in 10 paediatric hospitals to investigate the rate of Sp bacteremia in children aged less than 5 years. The serotype prevalence and antimicrobial susceptibility of isolates were determined. A total of 55 Sp isolates were obtained from 4576 blood cultures (incidence rate, 1.2%). In order of frequency, the most common serotypes were 14, 23F, 19F, 9V, 1. Serotypes in the 7-valent conjugate pneumococcal vaccine (4, 6B, 9V, 14, 18C, 19F, 23F) accounted for 70% of isolates under 2 years of age, and 58% in the interval between 2 and 5 years of age.

Published
2005

11. Dell’ultimo Agostino Cornacchini. Tracce di uno scultore toscano all’Aquila / About the late activity of Agostino Cornacchini. Traces of a Tuscan sculptor in L'Aquila

Author

Luca Pezzuto and Tancredi Farina

Subjects
Arts in general, NX1-820, Auxiliary sciences of history
Abstract

Si intende fare luce sulla tarda attività di Agostino Cornacchini, scultore toscano e autore della statua equestre di Carlo Magno per il portico di San Pietro e poi restauratore del Laooconte, che si affermò nel panorama romano di primo Settecento grazie all’intercessione del cardinale Carlo Agostino Fabbroni e ai successivi favori di Clemente XII. La critica ne considerava interrotta la carriera, dopo un periodo di declino, tra il 1754 e il 1757; in realtà, in seguito ad una sfortunata parentesi napoletana, l’anziano artefice visse e lavorò altri cinque anni in Abruzzo. Il saggio, che permette di stabilirne con esattezza anche data e luogo del decesso, costituisce un approfondimento sul soggiorno aquilano di Cornacchini (databile ora con esattezza al quinquennio 1758-1762), grazie a nuovi ritrovamenti d’archivio, allo scandaglio di fonti finora non considerate e all’analisi stilistica delle opere superstiti. This paper intends to make light on the late phase of the activity of the Tuscan sculptor Agostino Cornacchini, who established himself in early eighteenth-century Rome thanks to the support of Cardinal Carlo Agostino Fabbroni and Pope Clement XII and is generally known for executing the Equestrian statue of Charlemagne for the portico of the St. Peter’s Basilica and restoring the Laocoön Group. According to the studies so far, his career came to and end between 1754 and 1757, after a period of decline; actually, following an unsuccessful experience in Naples, the elderly artist worked in the Abruzzi for five more years. The present contribution clarifies where and when Cornacchini died and offers and in-depth analysis of the period he spent in L’Aquila (now certainly datable to the years 1758-1762) by focusing on newly discovered archival documents and previously not considered sources, and examining the style of his works still preserved in L’Aquila.

Published
2021
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13. Bilateral forearm and hand compartment syndrome following thrombolysis for acute myocardial infarction: A case report

Author

Tancredi F. D'Amore, Curtis N. Harris, William O. Thomas, and Samuel W. Parry

Subjects
Adult, Male, medicine.medical_specialty, Decompression, medicine.medical_treatment, Myocardial Infarction, Compartment Syndromes, Catheterization, Forearm, medicine.artery, medicine, Humans, Thrombolytic Therapy, Myocardial infarction, Radial artery, Monitoring, Physiologic, business.industry, Vascular disease, Thrombolysis, Hand, medicine.disease, Surgery, medicine.anatomical_structure, Emergency Medicine, business, Complication
Abstract

A patient suffering from a cocaine-induced myocardial infarction was treated with thrombolytic therapy and developed acute bilateral compartment syndromes of the upper extremities and hands from bleeding due to attempted bilateral radial artery cannulation. He was treated with emergent decompression of the forearm compartments and intrinsic muscles of the hands and recovered excellent hand function without significant neurologic or muscular damage. The problems encountered in the management of this case are detailed, and recommendations for prevention and therapy are discussed.

Published
1994
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14. [Air pollution in an urban area nearby the Rome-Ciampino city airport]

Author

Di Menno Di Bucchianico, A, Cattani, G, Gaeta, A, Caricchia, Am, Troiano, F, Sozzi, R, Bolignano, A, Sacco, F, Damizia, S, Barberini, S, Caleprico, R, Fabozzi, T, Ancona, C, Ancona, L, Cesaroni, G, Forastiere, F, Gobbi, Gp, Costabile, F, Angelini, F, Barnaba, F, Inglessis, M, Tancredi, F, Palumbo, L, Fontana, Luca, Bergamaschi, A, Iavicoli, Ivo, Di Menno Di Bucchianico, A, Cattani, G, Gaeta, A, Caricchia, Am, Troiano, F, Sozzi, R, Bolignano, A, Sacco, F, Damizia, S, Barberini, S, Caleprico, R, Fabozzi, T, Ancona, C, Ancona, L, Cesaroni, G, Forastiere, F, Gobbi, Gp, Costabile, F, Angelini, F, Barnaba, F, Inglessis, M, Tancredi, F, Palumbo, L, Fontana, Luca, Bergamaschi, A, and Iavicoli, Ivo

Abstract

to assess air pollution spatial and temporal variability in the urban area nearby the Ciampino International Airport (Rome) and to investigate the airport-related emissions contribute.

Published
2014

15. Is the interruption of antiretroviral treatment during pregnancy an additional major risk factor for mother-to-child transmission of HIV type 1?

Author

Galli, L, Puliti, D, Chiappini, E, Gabiano, C, Ferraris, G, Mignone, F, Viganò, A, Giaquinto, C, Genovese, O, Anzidei, G, Badolato, R, Buffolano, W, Maccabruni, A, Salvini, F, Cellini, M, Ruggeri, M, Manzionna, M, Bernardi, S, Tovo, P, de Martino, M, De Benedictis, F, Osimani, P, La Rovere, D, Quercia, M, Baldi, F, Ciccia, M, Faldella, A, Masi, M, Plebani, A, Spinelli, E, Dedoni, M, Gariel, D, Chiarello, P, Magnolia, Mg, Sticca, M, Vivalda, L, Bezzi, Teresa Maria, Fiumana, Elisa, Bianchi, L, Battiglia, N, Gervaso, P, Bondi, E, Cosso, D, Gotta, C, Ginocchio, L, Rosso, R, Viscoli, C, Amoretti, C, Esposito, S, Farina, F, Giacomet, V, Lipreri, R, Salvatici, E, Stucchi, S, Palazzi, G, Paolucci, P, De Luca, G, Giannattasio, A, Tancredi, F, Tarallo, L, Rampon, O, Dalle Nogare, E, Romano, A, Saitta, M, Mariani, B, Biver, P, Consolini, R, Palla, G, De Fanti, A, Dodi, I, Verna, M, Bove, G, Casadei, Am, Castelli Gattinara, G, Catania, S, Martino, Am, Sirufo, Mm, Ganau, A, Cristiano, L, Scolfaro, C, Versace, A, Portelli, V, Gentilini, L, Mazza, A, Bernardon, M, Bua, J, Rabusin, M, Pellegatta, A, Fortunati, P., Galli, L, Puliti, D, Chiappini, E, Gabiano, C, Ferraris, G, Mignone, F, Viganò, A, Giaquinto, C, Genovese, O, Anzidei, G, Badolato, R, Buffolano, Wilma, Maccabruni, A, Salvini, F, Cellini, M, Ruggeri, M, Manzionna, M, Bernardi, S, Tovo, P, de Martino, M, and Italian Register for HIV Infection in, C. h. i. l. d. r. e. n.

Subjects
Microbiology (medical), antiretroviral treatment, medicine.medical_specialty, Anti-HIV Agents, Pregnancy Trimester, Third, HIV Infections, transmission mother-to-child, HIV infection, Cohort Studies, HIV, Italian Register for HIV Infection in Children, therapeutic use, Cohort Studies, Delivery, Obstetric, Female, HIV Infections, drug therapy/transmission, HIV-1, isolation /&/ purification, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Pregnancy, Pregnancy Complications, Infectious, drug therapy, Pregnancy Trimester, First, Pregnancy Trimester, Third, Prospective Studies, Risk Factors, Viral Load, Withholding Treatment, Pregnancy, Risk Factors, medicine, Elective Cesarean Delivery, Humans, Prospective Studies, Risk factor, Pregnancy Complications, Infectious, Maternal Transmission, Obstetrics, business.industry, Infant, Newborn, Viral Load, medicine.disease, Delivery, Obstetric, Confidence interval, Infectious Disease Transmission, Vertical, Surgery, Pregnancy Trimester, First, Infectious Diseases, Withholding Treatment, Cohort, HIV-1, Gestation, Female, business, Viral load
Abstract

There is currently an experts' agreement discouraging interruption of antiretroviral treatment (ART) during the first trimester of pregnancy in women infected with human immunodeficiency virus type 1 (HIV-1). However, this recommendation is poorly supported by data. We evaluated the effects of discontinuing ART during pregnancy on the rate of mother-to-child transmission.Logistic regression models were performed in a prospective cohort of 937 children who were perinatally exposed to HIV-1 to estimate adjusted odds ratios for confounding factors on mother-to-child transmission, including maternal interruption of ART.Among 937 pregnant women infected with HIV-1, ART was interrupted in 81 (8.6%) in the first trimester and in 11 (1.2%) in the third trimester. In the first trimester, the median time at suspension of ART was 6 weeks (interquartile range [IQR], 5-6 weeks) and the time without treatment was 8 weeks (IQR, 7-11 weeks). In the third trimester, the median time at suspension of ART was 32 weeks (IQR, 23-36 weeks) and the time without treatment was 6 weeks (IQR, 2-9 weeks). The plasma viral load was similar in women who had treatment interrupted in the first trimester and in those who did not have treatment interrupted. Overall, the rate of mother-to-child transmission in the whole cohort was 1.3% (95% confidence interval [CI], 0.7%-2.3%), whereas it was 4.9% (95% CI, 1.9%-13.2%) when ART was interrupted in the first trimester and 18.2% (95% CI, 4.5%-72.7%) when ART was interrupted in the third trimester. In the multiple logistic regression models, only interruption of ART during either the first or the third trimester, maternal mono- or double therapy, delivery by a mode other than elective cesarean delivery, and a viral load at delivery4.78 log(10) copies/mL were independently associated with an increased rate of mother-to-child transmission.Discontinuing ART during pregnancy increases the rate of mother-to-child transmission of HIV-1, either when ART is stopped in the first trimester and subsequently restarted or when it is interrupted in the third trimester. This finding supports recommendations to continue ART in pregnant women who are already receiving treatment for their health.

Published
2009

17. LOW PREVALENCE OF SELECTIVE IgA DEFICIENCY IN INFECTED CHILDREN BORN TO HIV-SEROPOSITIVE MOTHERS: AN IN VIVO MODEL FOR SPECULATION ON SELECTIVE IgA DEFICIENCY PATHOGENESIS

Author

Author:, Chiappini, Galli, E, Tovo, L, Gabiano, Pa, Lisi, C, Ferraris, C, Vigano, G, Giaquinto, A, Bernardi, C, Badolato, S, Genovese, R, Salvini, O, Maccabruni, F, Anzidei, A, Rosso, G, Buffolano, R, Cellini, W, Casadei, M, Faldella, Am, Ruggeri, G, Osimani, M, Manzionna, P, Dodi, Mm, Gotta, I, Esposito, C, Gariel, S, D, Martino, De, M, Group Author: Italian Register HIV Infect Children:Osimani, Cordialir, P, Mattia, De, Manzionna, D, Bari, Di, Ruggeri, C, Masi, M, Miniaci, M, Specchia, A, Ciccia, F, Lanari, M, Baldi, M, Sinelli, F, Bennato, M, Dedoni, B, Fenu, M, Cavallini, R, Anastasio, E, Zicchinelli, D, Sticca, M, Pomero, G, Contiero, R, Fiumana, E, Bonsignori, F, Gervaso, P, Innocenti, L, Cecchoi, Mt, Viscoli, C, Ginocchio, F, Nicolini, La, Ciravegna, Bw, Cosso, D, Timitilli, A, Stronati, M, Plebani, A, Bonjanin, J, Porta, A, Principi, N, Giacomet, V, Bianchi, R, Zuccotti, Gv, Giovannini, M, Ferraris, G, Liprieri, R, Moretti, C, Cellini, M, Cano, Mc, Palazzi, G, Bruzzese, E, Giannattazio, A, Tarallo, L, Tancredi, F, D'Elia, R, Rampon, O, Dalle, Nogare, Sanfilippo, A, Romano, A, Saitta, M, Dodi, I, Barone, A, and Consolini, Rita

Published
2008

19. Changing patterns of clinical events in perinatally HIV-1-infected children during the era of HAART. The Italian Register for HIV Infection in Children

Author

WRITING COMMITTEE CHIAPPINI, E, Galli, L, Tovo, Pa, Gabiano, C, Lisi, C, Gattinara, Gc, Esposito, S, Viganò, A, Giaquinto, C, Rosso, R, Guarino, A, Osimani, DE MARTINO M. MEMBERS OF THE ITALIAN REGISTER FOR HIV INFECTION IN CHILDREN P., Cordiali, R., DE MATTIA, D., Manzionna, M., DI BARI, C., Ruggeri, M., Masi, M., Miniaci, A., Specchia, F., Ciccia, M., Lanari, M., Baldi, F., Battisti, L., Schumacher, R., Duse, M., Sinelli, M., Bennato, V., Dessì, C., Dedoni, M., Fenu, M. L., Cavallini, R., Anastasio, E., Zicchinella, D., Sticca, M., Pomero, G., Contiero, R., Fiumana, E., Gervaso, P., Gabrielli, G., Braccesi, G., Becherucci, S., DE GAUDIO, M., Innocenti, L., Cecchi, M. T., Ginocchio, F., Nicolini, L. A., Ciravegna, B. W., Cosso, D., Timitilli, A., Stronati, M., Plebani, A., Bojanin, J., Porta, A., Principi, N., Giacomet, V., Bianchi, R., Zuccotti, G. V., Giovannini, M., Ferraris, G., Lipreri, R., MORETTI MILANO, C., Cellini, M., Cano, M. C., Palazzi, G., Bruzzese, E., Giannattazio, A., Tarallo, L., Tancredi, F., D'Elia, R., Rampon, O., DALLE NOGARE, E. R., Sanfilippo, A., Romano, A., Saitta, M., Dodi, I., Barone, A., Consolini, Rita, Legitimo, Annalisa, Magnani, C., Falconieri, P., Fundarò, C., Salvucci, P. VALENTINI S., Casadei, A. M., Bernardi, S., Palma, P., Anzidei, M., Cerilli, S., Ajassa, C., Ganau, A., Cristiano, L., Mazza, A., Gentilini, L., Mignone, F., Versace, A., Antonielli, E., Sovatzis, S., Scolfaro, C., Palomba, E., Portelli, V., Rabusin, M., Pellegatta, A., and Fortunati, P.

Published
2007

20. Cancer rates after year 2000 significantly decrease in children with perinatal HIV infection: A study by the Italian Register for HIV Infection in Children

Author

Chiappini, E, Galli, L, Tovo, Pa, Gabiano, C, Lisi, C, Giaquinto, C, Rampon, O, Gattinara, Gc, De Marco, G, Osimani, P, Manzionna, M, Miniaci, A, Pintor, C, Rosso, R, Esposito, S, Viganò, A, Dodi, I, Maccabruni, A, Fundarò, C, de Martino, M, Osimani, P., Cordiali, R., De Mattia, D., Manzionna, M., Di Bari, C., Ruggeri, M., Masi, M., Miniaci, A., Specchia, F., Ciccia, M., Lanari, M., Baldi, F., Battisti, L., Fiorino, C., Dessı`, C., Pintor, C., Dedoni, M., Fenu, M. L., Cavallini, R., Anastasio, E., Merolla, F., Sticca, M., Pomero, G., Bezzi, Teresa Maria, Fiumana, Elisa, Bonsignori, F., Gervaso, P., Seini, E., Cecchi, M. T., Cosso, D., Timitilli, A., Stronati, M., Plebani, A., Pinzani, R., Bongianin, I., Vigano`, A., Giacomet, V., Erba, P., Salvini, F., Zuccotti, G. V., Giovannini, M., Ferraris, G., Lipreri, R., Moretti, C., Cellini, M., Cano, M. C., Paolucci, P., Bruzzese, E., De Marco, G., Tarallo, L., Tancredi, F., Pennazzato, M., Rampon, O., Dalle Nogare, E. R., Sanfilippo, A., Romano, A., Saitta, M., Dodi, I., Barone, A., Maccabruni, A., Consolini, R., Legitimo, A., Magnani, C., Falconieri, P., Fundaro`, C., Genovese, O., Panzanella, A., Casadei, A. M., Martino, A., Concato, C., Anzidei, G., Bove, G., Cerilli, S., Catania, S., Ajassa, C., Ganau, A., Cristiano, L., Mazza, A., Di Palma, A., Mignone, F., Riva, C., Scorfaro, C., Portelli, V., Rabusin, M., Pellegatta, A., Molesini, M., Chiappini, Elena, Galli, Luisa, Tovo, Pier-Angelo, Gabiano, Clara, Lisi, Catiuscia, Giaquinto, Carlo, Rampon, Osvalda, Gattinara, Guido Castelli, De Marco, Giulio, Osimani, Patrizia, Manzionna, Mariano, Miniaci, Angela, Pintor, Carlo, Rosso, Raffaella, Esposito, Susanna, Viganò, Alessandra, Dodi, Icilio, Maccabruni, Anna, Fundarò, Carlo, De Martino, Maurizio, Italian Register for HIV Infection in, Children, and Lanari, M.

Subjects
Registrie, Pediatrics, Cancer Research, Time Factors, HIV Infections, Antiretroviral Therapy, Highly Active, Neoplasms, HIV Infection, Registries, Sida, Child, biology, Incidence (epidemiology), Medicine (all), Incidence, Child, Preschool, Disease Progression, Humans, Infant, Infant, Newborn, Italy, Treatment Outcome, Oncology, symbols, Population study, Viral disease, Human, medicine.medical_specialty, cancer rates, HIV infection, children, Time Factor, Antiretroviral Therapy, symbols.namesake, Acquired immunodeficiency syndrome (AIDS), medicine, cancer, Highly Active, Poisson regression, Preschool, Settore MED/38 - Pediatria Generale e Specialistica, Perinatal HIV infection, business.industry, Cancer, Newborn, medicine.disease, biology.organism_classification, Italian Register for HIV infection in children, El Niño, Neoplasm, business
Abstract

Purpose To evaluate the impact of highly active antiretroviral therapy (HAART) on cancer incidence in HIV-infected children throughout a 20-year period. Patients and Methods An observational population study was conducted on 1,190 perinatally HIV-infected children enrolled onto the Italian Register for HIV Infection in Children from 1985 to 2004 and never lost to follow-up (total observation time, 10,037.66 years). Cancer rates were calculated in the pre-HAART (1985 to 1995), early HAART (1996 to 1999), and late HAART (2000 to 2004) periods and compared using Poisson regression adjusted for age. The proportion of HAART-treated children increased from 4.1% in 1996 to 60.4% in 1999 and to 81.5% in 2004. In the same time frame, the proportion of children receiving HAART for at least 2 years increased from 3.1% to 77.0%. Results Overall, 35 cancers occurred. Cancer rates were 4.49 (95% CI, 2.37 to 6.64), 4.09 (95% CI, 1.68 to 6.50), and 0.76 (95% CI, 0.00 to 1.80) per 1,000 children per year in 1985 to 1995, 1996 to 1999, and 2000 to 2004, respectively. Notably, there was no significant difference comparing the periods from 1985 to 1995 and 1996 to 1999 (P = .081). By contrast, cancer rates were significantly lower in the period from 2000 to 2004 than in 1996 to 1999 (P < .0001). Results were confirmed by separately analyzing data from children observed from birth (P = .418 for 1985 to 1995 v 1996 to 1999; P = .001 for 1996 to 1999 v 2000 to 2004). Conclusion Dramatically reduced cancer rates were observed only in the late HAART period in parallel to the increasing proportion of children receiving HAART therapy.

Published
2007

21. Virologic, immunologic, and clinical benefits from early combined antiretroviral therapy in infants with perinatal HIV-1 infection

Author

Chiappini, E., Galli, L., Atovo, P. i. e. r., Gabiano, C., Castelli Gattinara, G., Guarino, A., Baddato, R., Giaquinto, C., Lisi, C., de Martino, M., Osimani, P., Cordiali, R., De Mattia, D., Manzionna, M., Di Bari, C., Ruggeri, M., Masi, M., Miniaci, A., Specchia, F., Ciccia, M., Lanari, M., Baldi, F., Battisti, L., Fiorino, C., Dessı`, C., Pintor, C., Dedoni, M., Fenu, M. L., Cavallini, R., Anastasio, E., Merolla, F., Sticca, M., Pomero, G., Bezzi, Teresa Maria, Fiumana, Elisa, Bonsignori, F., Gervaso, P., Seini, E., Cecchi, M. T., Cosso, D., Timitilli, A., Stronati, M., Plebani, A., Pinzani, R., Bongianin, I., Vigano`, A., Giacomet, V., Erba, P., Salvini, F., Zuccotti, G. V., Giovannini, M., Ferraris, G., Lipreri, R., Moretti, C., Cellini, M., Cano, M. C., Paolucci, P., Bruzzese, E., De Marco, G., Tarallo, L., Tancredi, F., Pennazzato, M., Rampon, O., Dalle Nogare, E. R., Sanfilippo, A., Romano, A., Saitta, M., Dodi, I., Barone, A., Maccabruni, A., Consolini, R., Legitimo, A., Magnani, C., Falconieri, P., Fundaro`, C., Genovese, O., Panzanella, A., Casadei, A. M., Martino, A., Concato, C., Anzidei, G., Bove, G., Cerilli, S., Catania, S., Ajassa, C., Ganau, A., Cristiano, L., Mazza, A., Di Palma, A., Mignone, F., Riva, C., Scorfaro, C., Portelli, V., Rabusin, M., Pellegatta, A., Molesini, M., Chiappini, E, Galli, L, Tovo, Pa, Gabiano, C, Gattinara, Gc, Guarino, Alfredo, Baddato, R, Giaquinto, C, Lisi, C, and DE MARTINO, M.

Subjects
medicine.medical_specialty, Pediatrics, Anti-HIV Agents, medicine.medical_treatment, Immunology, combined antiretroviral therapy, CD4-CD8 Ratio, HIV Infections, HIV-1 infection, Asymptomatic, Drug Administration Schedule, Acquired immunodeficiency syndrome (AIDS), Immunopathology, Antiretroviral Therapy, Highly Active, Medicine, Immunology and Allergy, Humans, Sida, ART, infants, Chemotherapy, biology, business.industry, Age Factors, Infant, Viral Load, biology.organism_classification, medicine.disease, Infectious Disease Transmission, Vertical, Surgery, CD4 Lymphocyte Count, Infectious Diseases, Treatment Outcome, Child, Preschool, Lentivirus, Disease Progression, HIV-1, Viral disease, medicine.symptom, business, Epidemiologic Methods, Viral load
Abstract

Objective: To investigate the impact of early versus deferred combined antiretroviral treatment (ART) in asymptomatic or moderately symptomatic [Centers for Disease Control and Prevention (CDC) category N, A or B] infants with perinatal HIV-1 infection. Methods: A multi-centre nationwide case-control study was conducted. Data from 30 infants treated with combined ART with three or more drugs before 6 months of age were compared with data from 103 infants starting ART with three or more drugs after 6 months of age. The median follow-up time was 4.1 years (range, 1.0-6.5 years). Results: No difference was evident in the first available viral load and CD4 T-lymphocyte percentage between the two groups of children. Early-treated infants showed significantly lower viral loads than infants receiving deferred treatment at all the follow-up periods. A higher proportion of early-treated infants than infants receiving deferred treatment (73.3% versus 30.1%; P < 0.0001) reached an undetectable viral load. Higher CD4 T-lymphocyte percentages were found in early-treated infants at 13-24 (P < 0.0001), 25-36 (P < 0.0001), and 37-48 (P = 0.003) months of age. No early-treated infant versus 20 of 103 (19.4%) infants receiving deferred ART (P=0.02) showed a CD4 T-lymphocyte percentage of less than 15% at one time point during follow-up. No CDC category A, B or C clinical event occurred in early-treated infants over the follow-up period while 44 of 103 (42.7%) infants receiving deferred treatment presented a decline in the CDC category. Kaplan-Meier analyses revealed significant differences in CDC category A (P = 0.0002), B (P = 0.0003), and C (P = 0.0018) event-free survivals. Conclusion: The data suggest virologic, immunologic, and clinical benefits from early administration of ART.

Published
2006

22. Early triple therapy vs mono or dual therapy for children with perinatal HIV infection

Author

Chiappini, E, Galli, L, Gabiano, C, Tovo, Pa, de Martino, M, Osimani, P., Cordiali, R., De Mattia, D., Manzionna, M., Di Bari, C., Ruggeri, M., Masi, M., Miniaci, A., Specchia, F., Ciccia, M., Lanari, M., Baldi, F., Battisti, L., Fiorino, C., Dessı`, C., Pintor, C., Dedoni, M., Fenu, M. L., Cavallini, R., Anastasio, E., Merolla, F., Sticca, M., Pomero, G., Bezzi, Teresa Maria, Fiumana, Elisa, Bonsignori, F., Gervaso, P., Seini, E., Cecchi, M. T., Cosso, D., Timitilli, A., Stronati, M., Plebani, A., Pinzani, R., Bongianin, I., Vigano`, A., Giacomet, V., Erba, P., Salvini, F., Zuccotti, G. V., Giovannini, M., Ferraris, G., Lipreri, R., Moretti, C., Cellini, M., Cano, M. C., Paolucci, P., Bruzzese, E., De Marco, G., Tarallo, L., Tancredi, F., Pennazzato, M., Rampon, O., Dalle Nogare, E. R., Sanfilippo, A., Romano, A., Saitta, M., Dodi, I., Barone, A., Maccabruni, A., Consolini, R., Legitimo, A., Magnani, C., Falconieri, P., Fundaro`, C., Genovese, O., Panzanella, A., Casadei, A. M., Martino, A., Concato, C., Anzidei, G., Bove, G., Cerilli, S., Catania, S., Ajassa, C., Ganau, A., Cristiano, L., Mazza, A., Di Palma, A., Mignone, F., Riva, C., Scorfaro, C., Portelli, V., Rabusin, M., Pellegatta, A., Molesini, M., Chiappini E., Galli L., Gabiano C., Tovo P A., De Martino M., for the Italian Register for HIV Infection in Children: [.., Osimani P., Specchia F., Molesini M., and ]

Subjects
Perinatal HIV infection, Pediatrics, medicine.medical_specialty, HIV INFECTIONS, business.industry, Therapy, General Medicine, Virology, Perinatal hiv, medicine, INFANT, Dual therapy, business, MATERNAL-FETAL RELATIONS, DISEASE TRANSMISSION, ANTIHIV AGENTS
Abstract

The time at which antiretroviral therapy (ART) should be initiated in children with perinatal human immunodeficiencyvirus (HIV) infection remains controversial. In a cohort study, Berk et al1 reported clinical benefit from mono/dual ART started before 60 days of life in 10 children compared with treatment administered at 61 to 120 days of life in 16 children. The 23 children who received early triple ART were not investigated because none of them progressed to category C diagnosis by 3 years of age. We performed a similar analysis in a cohort study of a larger data set of children with a longer follow-up to evaluate the outcomes of early and very early triple ART.

Published
2006

23. Lower mother-to-child HIV-1 transmission in boys is independent of type of delivery and antiretroviral prophylaxis. The Italian register for HIV intection in children

Author

Galli, L., Puliti, D., Chiappini, E., Gabiano, C., Tovo, P. A., Pezzotti, P., de Martino, M., Osimani, P., Cordiali, R., De Mattia, D., Manzionna, M., Di Bari, C., Ruggeri, M., Masi, M., Miniaci, A., Specchia, F., Ciccia, M., Lanari, M., Baldi, F., Battisti, L., Fiorino, C., Dessı`, C., Pintor, C., Dedoni, M., Fenu, M. L., Cavallini, R., Anastasio, E., Merolla, F., Sticca, M., Pomero, G., Bezzi, Teresa Maria, Fiumana, Elisa, Bonsignori, F., Gervaso, P., Seini, E., Cecchi, M. T., Cosso, D., Timitilli, A., Stronati, M., Plebani, A., Pinzani, R., Bongianin, I., Vigano`, A., Giacomet, V., Erba, P., Salvini, F., Zuccotti, G. V., Giovannini, M., Ferraris, G., Lipreri, R., Moretti, C., Cellini, M., Cano, M. C., Paolucci, P., Bruzzese, E., De Marco, G., Tarallo, L., Tancredi, F., Pennazzato, M., Rampon, O., Dalle Nogare, E. R., Sanfilippo, A., Romano, A., Saitta, M., Dodi, I., Barone, A., Maccabruni, A., Consolini, R., Legitimo, A., Magnani, C., Falconieri, P., Fundaro`, C., Genovese, O., Panzanella, A., Casadei, A. M., Martino, A., Concato, C., Anzidei, G., Bove, G., Cerilli, S., Catania, S., Ajassa, C., Ganau, A., Cristiano, L., Mazza, A., Di Palma, A., Mignone, F., Riva, C., Scorfaro, C., Portelli, V., Rabusin, M., Pellegatta, A., and Molesini, M.

Subjects
infant's gender, vertical transmission, antiretroviral prophylaxis
Published
2005

24. Persistently high IgA serum levels are a marker of immunological or virological failure of combined antiretroviral therapy in children with perinatal HIV-1 infection

Author

Chiappini, E., Galli, L., Tovo, P. A., Gabiano, C., de Martino, M., Osimani, P., Cordiali, R., De Mattia, D., Manzionna, M., Di Bari, C., Ruggeri, M., Masi, M., Miniaci, A., Specchia, F., Ciccia, M., Lanari, M., Baldi, F., Battisti, L., Fiorino, C., Dessı`, C., Pintor, C., Dedoni, M., Fenu, M. L., Cavallini, R., Anastasio, E., Merolla, F., Sticca, M., Pomero, G., Bezzi, Teresa Maria, Fiumana, Elisa, Bonsignori, F., Gervaso, P., Seini, E., Cecchi, M. T., Cosso, D., Timitilli, A., Stronati, M., Plebani, A., Pinzani, R., Bongianin, I., Vigano`, A., Giacomet, V., Erba, P., Salvini, F., Zuccotti, G. V., Giovannini, M., Ferraris, G., Lipreri, R., Moretti, C., Cellini, M., Cano, M. C., Paolucci, P., Bruzzese, E., De Marco, G., Tarallo, L., Tancredi, F., Pennazzato, M., Rampon, O., Dalle Nogare, E. R., Sanfilippo, A., Romano, A., Saitta, M., Dodi, I., Barone, A., Maccabruni, A., Consolini, R., Legitimo, A., Magnani, C., Falconieri, P., Fundaro`, C., Genovese, O., Panzanella, A., Casadei, A. M., Martino, A., Concato, C., Anzidei, G., Bove, G., Cerilli, S., Catania, S., Ajassa, C., Ganau, A., Cristiano, L., Mazza, A., Di Palma, A., Mignone, F., Riva, C., Scorfaro, C., Portelli, V., Rabusin, M., Pellegatta, A., Molesini, M., Chiappini E., Galli L., Tovo PA., Gabiano C., de Martino M., Osimani P, Masi M., Specchia F., Molesini M., and The Italian Register for HIV Infection in Children

Subjects
Adolescent, Anti-HIV Agents, Immunology, HIV Infections, HIV-1 infection, Perinatal hiv, Antiretroviral Therapy, Highly Active, Clinical Studies, Immunology and Allergy, Medicine, Humans, Treatment Failure, Child, viremia, business.industry, combinedantiretroviral therapy, hyper-IgA, Infant, Newborn, Normal population, Infant, Viral Load, Antiretroviral therapy, Virological failure, Infectious Disease Transmission, Vertical, CD4 Lymphocyte Count, Immunoglobulin A, Child, Preschool, HIV-1, Drug Monitoring, business, Viral load, Biomarkers, Follow-Up Studies
Abstract

Summary Non-expensive and low-complexity surrogate markers for monitoring the response to combined antiretroviral therapy (combined-ART) are needed in poor-resource settings where routine assessment of CD4+ T-lymphocyte count and viral load can not be afforded. We longitudinally evaluated Ig serum levels in 234 HIV-1 infected children receiving combined-ART with ≥ 3 drugs. Since Ig levels physiologically vary with age, differences at different age periods were evaluated as differences in z-scores calculated using the mean and standard deviation of the normal population for each age period. Data from 17 (7·3%) children with immunological failure and from 54 (23·1%) children with virological failure of combined-ART were compared with data from not-failed children. At baseline children with immunological failure showed higher IgM z-scores (P = 0·042) than children without. After 3–12 months of therapy immunologically failed children displayed higher viral loads (P < 0·0001) and IgA (P = 0·043) z-scores than not-failed children. Similarly, at the same follow-up time, children with virological failure showed lower CD4+ T-lymphocyte percentages (P = 0·005) and higher IgA z-scores (P < 0·0001) than not-failed children. No difference in IgG or IgM z-scores was evidenced between failed and not-failed children after 3–12 months of therapy. In conclusion, IgA serum level is a cheap and low-complexity marker of immunological or virological failure of combined-ART which might be adopted in poor-resource settings.

Published
2005

25. Risk factors for congenital hypothyroidism: results of a population case-control study

Author

Medda, E, Olivieri, A, Stazi, Ma, Grandolfo, Me, Fazzini, C, Baserga, M, Burroni, M, Cacciari, E, Calaciura, F, Cassio, A, Chiovato, L, Costa, Pietro, Leonardi, D, Martucci, M, Moschini, L, Pagliardini, S, Parlato, G, Pignero, A, Pinchera, A, Sala, D, Sava, L, Stoppioni, V, Tancredi, F, Valentini, F, Vigneri, R, and Sorcini, M.

Published
2005

28. Role of Mycoplasma pneumoniae and Chlamydia pneumoniae in children with community-acquired lower respiratory tract infections

Author

Principi, N., Esposito, S., Blasi, F., Allegra, L., Longhi, R., Grasso, R. M., Vaccaro, R., Troiani, S., Tancredi, F., Tarallo, L., Gargantini, L., Cazzaniga, P., Titone, L., Cascio, A., Zannino, L., Navone, C., Debbia, C., Nespoli, L., Ossola, E., Schettini, F., Rigillo, N., Amendola, F., Mappa, L., Bona, G., Ronchi, B., Bernasconi, S., Iughetti, Lorenzo, Cocuzza, S., Raggi, M., Barberi, I., Lombardo, G., Gitto, S., Sirchia, T., Volpato, S., Voghenzi, A., Caramia, G., Ruffini, E., Cordelli, F., Brutti, R., Santovito, S., Catania, S., and Ajassa, C.

Subjects
Male, Microbiology (medical), Acute Disease, Pneumonia, Mycoplasma, Humans, Child, Mycoplasma pneumoniae, Preschool, Anti-Bacterial Agents, Prospective Studies, Respiratory Tract Infections, Chlamydia Infections, Treatment Outcome, Community-Acquired Infections, Adolescent, Chlamydophila pneumoniae, Time Factors, Female, Mycoplasmataceae, medicine.disease_cause, Lower respiratory tract infection, Pneumonia, Mycoplasma, medicine, Chlamydiaceae, Chlamydia, Respiratory tract infections, biology, business.industry, Chlamiydia pneumoniae, medicine.disease, biology.organism_classification, respiratory tract diseases, Infectious Diseases, Child, Preschool, Immunology, business
Abstract

In order to evaluate the role of Mycoplasma pneumoniae and Chlamydia pneumoniae, we studied 613 children aged 2-14 years who were hospitalized for community-acquired lower respiratory tract infections (LRTIs). The patients were enrolled in the study by 21 centers in different regions of Italy from May 1998 through April 1999. Paired serum samples were obtained on admission and after 4-6 weeks to assay the titers of M. pneumoniae and C. pneumoniae antibodies. Nasopharyngeal aspirates for the detection of M. pneumoniae and C. pneumoniae were obtained on admission. Acute M. pneumoniae infections in 210 patients (34.3%) and acute C. pneumoniae infections in 87 (14.1%) were diagnosed. Fifteen of the 18 children with M. pneumoniae and/or C. pneumoniae infections whose treatments were considered clinical failures 4-6 weeks after enrollment had not been treated with macrolides. Our study confirms that M. pneumoniae and/or C. pneumoniae plays a significant role in community-acquired LRTIs in children of all ages and that such infections have a more complicated course when not treated with adequate antimicrobial agents.

Published
2001

31. Isolated palmar displaced fracture of the base of the index metacarpal: a case report

Author

Tancredi F. D'Amore, Mobile Al, Curtiss N. Harris, William O. Thomas, Samuel W. Parry, and William M. G ottliebson

Subjects
musculoskeletal diseases, Dorsum, Adult, Male, medicine.medical_specialty, Joint Dislocations, Thumb, Fractures, Bone, Small finger, medicine, Humans, Orthopedics and Sports Medicine, Displacement (orthopedic surgery), business.industry, Fracture Dislocations, Anatomy, Surgery, body regions, Hand swelling, Radiography, medicine.anatomical_structure, Fracture (geology), Metacarpus, business, Palm
Abstract

The current literature contains an abundance of references citing fracture dislocations of the thumb, ring, and small finger carpometacarpal joints, but there are few reports of index and long finger carpometacarpal fractures or fracture dislocations. Isolated injuries of these joints are decidedly rare, and in those instances where fracture dislocations are reported, they are essentially all dorsally directed and usually involve multiple joints. Only four cases of isolated palmar dislocation of the index and long finger carpometacarpal joints have been reported. These reported cases have not documented associated bony fractures, and none involved only the index metacarpal. We present a case of an isolated fracture dislocation of the base of the index metacarpal with displacement of the base fragment into the palm. examination was remarkable for diffuse hand swelling, and a dorsal bony defect was found despite the marked swelling. Additionally, there was an area of tenderness ulnar to the thenar emminence. and attempted flexion of the fingers elicited palmar pain. Anteroposterior and oblique x-ray films showed irregularity of the base of the index metacarpal and a

Published
1994

47. Acute renal failure due to cisplatin

Author

Ng, Santo, Giovambattista Capasso, Capodicasa G, Tancredi F, Nuzzi F, Giordano C, DE SANTO, Ng, Capasso, Giovambattista, Capodicasa, G, Tancredi, F, Nuzzi, F, and Giordano, C.

Subjects
Biopsy, Needle, Humans, Female, Neuroectodermal Tumors, Primitive, Peripheral, Acute Kidney Injury, Cisplatin, Thoracic Neoplasms, Child, Glomerular Mesangium
Abstract

A case of acute renal failure associated with cisplatin therapy for a stage IV neuroepitelioma of the chest wall is described. This case was associated with a normal magnesium concentration and with presence of fibrinogen in the Tubular Basement Membrane and of IgG in the interstitial infiltrates. Immunological activation was evidentiated by fine needle aspiration biopsy (FNAB) at the time of renal biopsy.

50. Air pollution in an urban area nearby the Rome-Ciampino city airport | Inquinamento atmosferico in un'area urbana limitrofa all'aeroporto di Roma-Ciampino

Author

Di Menno Di Bucchianico, A., Cattani, G., Gaeta, A., Caricchia, A. M., Troiano, F., Sozzi, R., Bolignano, A., Sacco, F., Damizia, S., Barberini, S., Caleprico, R., Fabozzi, T., Ancona, C., Ancona, L., Cesaroni, G., Forastiere, F., Gobbi, G. P., Costabile, F., Angelini, F., Barnaba, F., Inglessis, M., Tancredi, F., Palumbo, L., Fontana, L., Bergamaschi, A., Iavicoli, I., Badaloni, C., Bucci, S., Golini, M. N., Mataloni, F., Morciano, C., Salatino, C. G., Zirro, E., Bignardi, G., Briotti, V., Piatti, R., Lauretis, R., Romano, D., Amadasi, C., Cestari, L., Dorio, R., Palazzi, B., Zangrando, D., Simonato, L., Sepulcri, D., Arcadi, C., Bandroco, L., Barra, G., Bellone, F., Carnà, P., Casu, P., Conchedda, M., Fano, C., Di Gilio, P., Macario, A., Peritore, M., Sapetti, S., Signorile, L., Tempia, V., Ottino, M., Chiusolo, M., Fogola, J., Cadum, E., Camerino, D., Consonni, D., Pesatori, A., Pier Alberto Bertazzi, Ferri, C., Minniti, C., Nanni, M., Petri, D., Vigotti, M. A., Licitra, G., Ascari, E., Antoniotti, M. C., Balconi, L., Bonarrigo, D., Stefani, C. D., Esposito, A., Gambino, M., Speziali, S., Pisani, S., Angius, S., Galbusera, E., Maggi, P., and Pollini, R.

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