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4 results on '"Tang, Defeng"'

2. High expression of proenkephalin is associated with favorable outcomes in patients with gastrointestinal stromal tumors

Author

Tang, Defeng, Lin, Tianlong, Wang, Yangyang, and Cao, Hui

Subjects
prognosis, PENK, Original Research, GIST
Abstract

Purpose The aim of this study was to elucidate the prognostic value of proenkephalin (PENK) in gastrointestinal stromal tumors (GISTs). Patients and methods We collected data on 268 eligible postoperative patients diagnosed with GIST between January 1, 2002, and December 31, 2011. PENK expression was detected in GIST tissues classified using the United States National Institutes of Health (NIH) risk classification system. The associations between high PENK expression and the clinicopathological characteristics were assessed. Overall survival (OS) and recurrence-free survival (RFS) were estimated by Kaplan–Meier analysis, and the log-rank test was used to compare the differences between groups. Univariate and multivariate Cox regression analyses were conducted to assess the prognostic value of PENK in GIST patients. Results High PENK expression was more common in the low- and intermediate-risk GIST groups compared with the high-risk group (P

Published
2019

4. hsa-miR-376c-3p Regulates Gastric Tumor Growth Both In Vitro and In Vivo.

Author

Tu, Lin, Zhao, Enhao, Zhao, Wenyi, Zhang, Zizhen, Tang, Defeng, Zhang, Yeqian, Wang, Chaojie, Zhuang, Chun, and Cao, Hui

Subjects
STOMACH tumors, APOPTOSIS, CANCER patients, CELL culture, CELL physiology, DNA, FLOW cytometry, GENE expression, IMMUNOHISTOCHEMISTRY, METASTASIS, POLYMERASE chain reaction, RESEARCH funding, RNA, XENOGRAFTS, VASCULAR endothelial growth factors, IN vitro studies, IN vivo studies, PREVENTION
Abstract

Background. In recent studies, aberrant expression of various microRNAs (miRNAs) is reported to be associated with gastric cancer metastasis. Method. Overexpression construct and inhibitor of hsa-miR-376c-3p were expressed in human gastric adenocarcinoma cell line SGC-7901. The expression level of tumor related genes was detected by qPCR, western blot, and immunostaining. Cell apoptosis was determined by flow cytometry. Xenograft of SGC-7901 cells was used to elucidate the function of hsa-miR-376c-3p in gastric tumor growth in vivo. Result. Expression of hsa-miR-376c-3p was detected in SGC-7901 cells. Downregulation of hsa-miR-376c-3p increased the expression level of BCL-2 and decreased the expression of smad4 and BAD. On the contrary, overexpression of hsa-miR-376c-3p increased the expression of BAD and smad4, while it led to the decreasing expression level of BCL-2. Overexpression of hsa-miR-376c-3p also promoted cell apoptosis in vitro and inhibited gastric tumor growth in vivo. Furthermore, the expression of BCL-2 was higher and expression of smad4 and BAD was lower in tumor tissue than the tissue adjacent to tumor from gastric cancer patients. Conclusion. This study demonstrated that hsa-miR-376c-3p plays an important role in the inhibition of gastric tumor growth and tumor related gene expression both in vitro and in vivo. [ABSTRACT FROM AUTHOR]

Published
2016
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