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20 results on '"Tang, Fangrong"'

5. Improving Prognosis of Surrogate Assay for Breast Cancer Patients by Absolute Quantitation of Ki67 Protein Levels Using Quantitative Dot Blot (QDB) Method

Author

Hao, Junmei, primary, Lyu, Yan, additional, Zou, Jiarui, additional, Zhang, Yunyun, additional, Xie, Shuishan, additional, Jing, Lili, additional, Tang, Fangrong, additional, Lyu, Jiahong, additional, Zhang, Wenfeng, additional, Zhang, Jianbo, additional, Wang, Xunting, additional, Chen, Kuisheng, additional, and Zhang, Jiandi, additional

Published
2021
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6. sj-docx-1-tct-10.1177_15330338211065603 - Supplemental material for 3D Visualization of the Dynamic Bidirectional Talk Between ER/PR and Her2 Pathways

Author

Lyv, Jiahong, Yu, Guohua, Zhang, Yunyun, Lyv, Yan, Zhang, Wenfeng, Zhang, Jiandi, and Tang, Fangrong

Subjects
110320 Radiology and Organ Imaging, FOS: Clinical medicine, Biochemistry, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-1-tct-10.1177_15330338211065603 for 3D Visualization of the Dynamic Bidirectional Talk Between ER/PR and Her2 Pathways by Jiahong Lyv, Guohua Yu, Yunyun Zhang, Yan Lyv, Wenfeng Zhang, Jiandi Zhang and Fangrong Tang in Technology in Cancer Research & Treatment

Published
2021
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11. 3D Visualization of the Dynamic Bidirectional Talk Between ER/PR and Her2 Pathways.

Author

Lyv, Jiahong, Yu, Guohua, Zhang, Yunyun, Lyv, Yan, Zhang, Wenfeng, Zhang, Jiandi, and Tang, Fangrong

Subjects
BREAST cancer, ESTROGEN receptors
Abstract

Background: Extensive amounts of archived formalin fixed paraffin embedded (FFPE) human tumor tissues are the ultimate resource to investigate signaling network underlying tumorigenesis in human. Yet, their usage is severely limited for lacking of suitable protein techniques. In this study, a quantitative, objective, absolute, and high throughput immunoblot method, quantitative dot blot (QDB), was explored to address this issue by investigating the putative relationship between estrogen receptor (ER)/progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her2) pathways in breast cancer tumorigenesis. Methods: In this descriptive observational retrospective study, ER, PR, Her2, and Ki67 protein levels were measured absolutely and quantitatively in 852 FFPE breast cancer tissues using the QDB method. ER, PR, and Her2 levels were charted on the X, Y, and Z-axes to observe samples distribution in a 3D scatterplot. Results: A "seesaw" relationship between ER/PR and Her2 pathways was observed in ER–PR–Her2 space, characterized by the expression levels of these 3 proteins. Specimens with strong expressions of ER/PR proteins were found spreading along the ER/PR floor while those with strong Her2 expression were found wrapping around the Her2 axis. Those lacking strong expressions of all 3 proteins were found accumulating at the intersection of the ER, PR, and Her2 axes. Few specimens floated in the ER–PR–Her2 space to suggest the lack of co-expression of all 3 proteins simultaneously. Ki67 levels were found to be significantly reduced in specimens spreading in the ER–PR space. Conclusions: The unique distribution of specimens in ER–PR–Her2 space prior to any clinical intervention provided visual support of bidirectional talk between ER/PR and Her2 pathways in breast cancer specimens. Clinical interventions to suppress these 2 pathways alternatively warrant further exploration for breast cancer patients accordingly. Our study also demonstrated that the QDB method is an effective tool to analyze archived FFPE cancer specimens in biomedical research. [ABSTRACT FROM AUTHOR]

Published
2021
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