27 results on '"Tang, Minzhong"'
Search Results
2. Host genetic variants, Epstein-Barr virus subtypes, and the risk of nasopharyngeal carcinoma: Assessment of interaction and mediation
- Author
-
Xu, Miao, Feng, Ruimei, Liu, Zhonghua, Zhou, Xiang, Chen, Yanhong, Cao, Yulu, Valeri, Linda, Li, Zilin, Liu, Zhiwei, Cao, Su-Mei, Liu, Qing, Xie, Shang-Hang, Chang, Ellen T., Jia, Wei-Hua, Shen, Jincheng, Yao, Youyuan, Cai, Yong-Lin, Zheng, Yuming, Zhang, Zhe, Huang, Guangwu, Ernberg, Ingemar, Tang, Minzhong, Ye, Weimin, Adami, Hans-Olov, Zeng, Yi-Xin, and Lin, Xihong
- Published
- 2024
- Full Text
- View/download PDF
3. High-throughput identification of regulatory elements and functional assays to uncover susceptibility genes for nasopharyngeal carcinoma
- Author
-
Wang, Tong-Min, Xiao, Ruo-Wen, He, Yong-Qiao, Zhang, Wen-Li, Diao, Hua, Tang, Minzhong, Mai, Zhi-Ming, Xue, Wen-Qiong, Yang, Da-Wei, Deng, Chang-Mi, Liao, Ying, Zhou, Ting, Li, Dan-Hua, Wu, Yan-Xia, Chen, Xue-Yin, Zhang, Jiangbo, Li, Xi-Zhao, Zhang, Pei-Fen, Zheng, Xiao-Hui, Zhang, Shao-Dan, Hu, Ye-Zhu, Cai, Yonglin, Zheng, Yuming, Zhang, Zhe, Zhou, Yifeng, Jin, Guangfu, Bei, Jinxin, Mai, Hai-Qiang, Sun, Ying, Ma, Jun, Hu, Zhibin, Liu, Jianjun, Lung, Maria Li, Adami, Hans-Olov, Ye, Weimin, Lam, Tai-Hing, Shen, Hongbing, and Jia, Wei-Hua
- Published
- 2023
- Full Text
- View/download PDF
4. A polygenic risk score for nasopharyngeal carcinoma shows potential for risk stratification and personalized screening
- Author
-
He, Yong-Qiao, Wang, Tong-Min, Ji, Mingfang, Mai, Zhi-Ming, Tang, Minzhong, Wang, Ruozheng, Zhou, Yifeng, Zheng, Yuming, Xiao, Ruowen, Yang, Dawei, Wu, Ziyi, Deng, Changmi, Zhang, Jiangbo, Xue, Wenqiong, Dong, Siqi, Zhan, Jiyun, Cai, Yonglin, Li, Fugui, Wu, Biaohua, Liao, Ying, Zhou, Ting, Zheng, Meiqi, Jia, Yijing, Li, Danhua, Cao, Lianjing, Yuan, Leilei, Zhang, Wenli, Luo, Luting, Tong, Xiating, Wu, Yanxia, Li, Xizhao, Zhang, Peifen, Zheng, Xiaohui, Zhang, Shaodan, Hu, Yezhu, Qin, Weiling, Deng, Bisen, Liang, Xuejun, Fan, Peiwen, Feng, Yaning, Song, Jia, Xie, Shang-Hang, Chang, Ellen T., Zhang, Zhe, Huang, Guangwu, Xu, Miao, Feng, Lin, Jin, Guangfu, Bei, Jinxin, Cao, Sumei, Liu, Qing, Kozlakidis, Zisis, Mai, Haiqiang, Sun, Ying, Ma, Jun, Hu, Zhibin, Liu, Jianjun, Lung, Maria Li, Adami, Hans-Olov, Shen, Hongbing, Ye, Weimin, Lam, Tai-Hing, Zeng, Yi-Xin, and Jia, Wei-Hua
- Published
- 2022
- Full Text
- View/download PDF
5. Transcriptome‐wide association analysis identified candidate susceptibility genes for nasopharyngeal carcinoma
- Author
-
He, Yong‐Qiao, primary, Xue, Wen‐Qiong, additional, Li, Dan‐Hua, additional, Wang, Tong‐Min, additional, Mai, Zhi‐Ming, additional, Yang, Da‐Wei, additional, Deng, Chang‐Mi, additional, Liao, Ying, additional, Zhang, Wen‐Li, additional, Xiao, Ruo‐Wen, additional, Luo, Luting, additional, Diao, Hua, additional, Tong, Xiating, additional, Wu, Yanxia, additional, Zhang, Jiang‐Bo, additional, Zhou, Ting, additional, Li, Xi‐Zhao, additional, Zhang, Pei‐Fen, additional, Zheng, Xiao‐Hui, additional, Zhang, Shao‐Dan, additional, Hu, Ye‐Zhu, additional, Tang, Minzhong, additional, Zheng, Yuming, additional, Cai, Yonglin, additional, Chang, Ellen T., additional, Zhang, Zhe, additional, Huang, Guangwu, additional, Cao, Su‐Mei, additional, Liu, Qing, additional, Feng, Lin, additional, Sun, Ying, additional, Lung, Maria Li, additional, Adami, Hans‐Olov, additional, Ye, Weimin, additional, Lam, Tai‐Hing, additional, and Jia, Wei‐Hua, additional
- Published
- 2022
- Full Text
- View/download PDF
6. Genome-Wide Association Study Implicates PARD3B-Based AIDS Restriction
- Author
-
Troyer, Jennifer L., Nelson, George W., Lautenberger, James A., Chinn, Leslie, McIntosh, Carl, Johnson, Randall C., Sezgin, Efe, Kessing, Bailey, Malasky, Michael, Hendrickson, Sher L., Li, Guan, Pontius, Joan, Tang, Minzhong, An, Ping, Winkler, Cheryl A., Limou, Sophie, Le Clerc, Sigrid, Delaneau, Olivier, Zagury, Jean-François, Schuitemaker, Hanneke, van Manen, Daniëlle, Bream, Jay H., Gomperts, Edward D., Buchbinder, Susan, Goedert, James J., Kirk, Gregory D., and O'Brien, Stephen J.
- Published
- 2011
- Full Text
- View/download PDF
7. Genetic Associations of Variants in Genes Encoding HIV-Dependency Factors Required for HIV-1 Infection
- Author
-
Chinn, Leslie W., Tang, Minzhong, Kessing, Bailey D., Lautenberger, James A., Troyer, Jennifer L., Malasky, Michael J., McIntosh, Carl, Kirk, Gregory D., Wolinsky, Steven M., Buchbinder, Susan P., Gomperts, Edward D., Goedert, James J., and O'Brien, Stephen J.
- Published
- 2010
8. Human leucocyte antigen alleles confer susceptibility and progression to Graves’ ophthalmopathy in a Southern Chinese population
- Author
-
Huang, Xiaosheng, primary, Liu, Guiqin, additional, Mei, Shaoyi, additional, Cai, Jiamin, additional, Rao, Jing, additional, Tang, Minzhong, additional, Zhu, Tianhui, additional, Chen, Wenchiew, additional, Peng, Shiming, additional, Wang, Yan, additional, Ye, Ye, additional, Zhang, Tong, additional, Deng, Zhihui, additional, and Zhao, Jun, additional
- Published
- 2020
- Full Text
- View/download PDF
9. P071 The HLA polymorphism in different npc incident rate region of China
- Author
-
Tang, Minzhong, primary, Cai, Yonglin, additional, Li, Jun, additional, and Zheng, Fuming, additional
- Published
- 2019
- Full Text
- View/download PDF
10. Diagnostic Significance of Combined Detection of Epstein-Barr Virus Antibodies, VCA/IgA, EA/IgA, Rta/IgG and EBNA1/IgA for Nasopharyngeal Carcinoma
- Author
-
Jun Li, Yuming Zheng, Ai-Ying Lu, Weiming Zhong, Wei Wang, Ji-ru Cheng, Tang Minzhong, Yong-Lin Cai, Hong Zeng, and Jianquan Gao
- Subjects
Adult ,Male ,China ,Epstein-Barr Virus Infections ,Herpesvirus 4, Human ,Cancer Research ,Epidemiology ,Antibodies, Viral ,medicine.disease_cause ,Sensitivity and Specificity ,Antigen ,otorhinolaryngologic diseases ,Carcinoma ,Humans ,Medicine ,Antigens, Viral ,Tumor marker ,Nasopharyngeal Carcinoma ,biology ,business.industry ,Public Health, Environmental and Occupational Health ,Area under the curve ,Nasopharyngeal Neoplasms ,Middle Aged ,medicine.disease ,Epstein–Barr virus ,Immunoglobulin A ,stomatognathic diseases ,Titer ,Logistic Models ,Epstein-Barr Virus Nuclear Antigens ,Oncology ,Nasopharyngeal carcinoma ,Case-Control Studies ,Immunoglobulin G ,Immunology ,biology.protein ,Capsid Proteins ,Female ,Antibody ,business - Abstract
The objective of this study was to investigate the diagnostic significance of EBV antibody combined detection for nasopharyngeal carcinoma (NPC) in a high incidence region of southern China. Two hundred and eleven untreated NPC patients, 203 non-NPC ENT patients, and 210 healthy controls were recruited for the study. The titers of VCA/IgA and EA/IgA were assessed by immunoenzyme assay, and the levels of Rta/IgG and EBNA1/IgA were determined by enzyme-linked immunosorbent assay. The levels of VCA/IgA, EA/IgA, Rta/IgG and EBNA1/ IgA demonstrated no association with gender or age (p>0.05). The receiver operating characteristic curve and the area under the curve were used to evaluate the diagnostic value. The sensitivity of VCA/IgA (98.1%) and the specificity of EA/IgA (98.5%) were the highest. When a logistic regression model was used to combine the results from multiple antibodies to increase the accuracy, the combination of VCA/IgA+Rta/IgG, whose area under the curve was 0.99, had the highest diagnostic efficiency, and its sensitivity, specificity and Youden index were 94.8%, 98.0% and 0.93 respectively. The data suggest that the combination of VCA/IgA+Rta/IgG may be most suitable for NPC serodiagnosis.
- Published
- 2014
11. Analytical “bake-off” of whole genome sequencing quality for the Genome Russia project using a small cohort for autoimmune hepatitis
- Author
-
Zhernakova, Daria V., primary, Kliver, Sergei, additional, Cherkasov, Nikolay, additional, Tamazian, Gaik, additional, Rotkevich, Mikhail, additional, Krasheninnikova, Ksenia, additional, Evsyukov, Igor, additional, Sidorov, Sviatoslav, additional, Dobrynin, Pavel, additional, Yurchenko, Andrey A., additional, Shimansky, Valentin, additional, Shcherbakova, Irina V., additional, Glotov, Andrey S., additional, Valle, David L., additional, Tang, Minzhong, additional, Shin, Emilia, additional, Schwarz, Kathleen B., additional, and O'Brien, Stephen J., additional
- Published
- 2018
- Full Text
- View/download PDF
12. Human leucocyte antigen alleles confer susceptibility and progression to Graves’ ophthalmopathy in a Southern Chinese population
- Author
-
Huang, Xiaosheng, Liu, Guiqin, Mei, Shaoyi, Cai, Jiamin, Rao, Jing, Tang, Minzhong, Zhu, Tianhui, Chen, Wenchiew, Peng, Shiming, Wang, Yan, Ye, Ye, Zhang, Tong, Deng, Zhihui, and Zhao, Jun
- Abstract
PurposeTo evaluate the contributions of human leucocyte antigen (HLA) class I and II genes in the development of Graves’ ophthalmopathy (GO) in a Southern Chinese population.MethodsEight HLA loci were genotyped and analysed in 272 unrelated patients with Graves’ disease (GD) or the proptosis and myogenic phenotypes of GO, and 411 ethnically matched control subjects.ResultsThe allele frequencies of HLA-DRB1*16:02and -DQB1*05:02in the GD, proptosis and myogenic groups, HLA-B*38:02and -DQA1*01:02in the myogenic group were significantly higher than those in the control group, respectively (all corrected p values <0.05, OR >2.5). The haplotype frequencies of HLA-DRB1*16:02-DQA1*01:02-DQB1*05:02and HLA-DRB1*16:02-DQA1*01:02-DQB1*05:02-DPA1*02:02-DPB1*05:01in the proptosis and myogenic groups, and HLA-A*02:03-B*38:02-C*07:02and HLA-A*02:03-B*38:02-C*07:02-DRB1*16:02-DQA1*01:02-DQB1*05:02-DPA1*02:02-DPB1*05:01in the myogenic group were significantly higher than those in the control group respectively (all corrected p values <0.05, OR >2.5). The potential epitopes (‘FLGIFNTGL’ of TSHR, ‘IRHSHALVS’, ‘ILYIRTNAS’ and ‘FVFARTMPA’ of IGF-1R) were fitted exactly in the peptide-binding groove between HLA-DRA1-DRB1*16:02heterodimer, and the epitopes (‘ILEITDNPY’ of THSR, ‘NYALVIFEM’ and ‘NYSFYVLDN’ of IGF-1R) were also fitted exactly in the peptide-binding groove between HLA-DQA1*01:02-DQB1*05:02heterodimer.ConclusionsThe HLA-DRB1*16:02and -DQB1*01:02alleles might be risk factors for GD including the proptosis and myogenic phenotypes of GO. The alleles HLA-B*38:02, -DQA1*01:02, the HLA haplotypes consisting of HLA-B*38:02, -DRB1*16:02, -DQA1*01:02and -DQB1*05:02might be susceptibility risk factors for GO. Simultaneously, some epitopes of TSHR and IGF-1R tightly binding to groove of HLA-DRA1-DRB1*16:02or HLA-DQA1*01:02-DQB1*05:02heterodimers might provide some hints on presenting the pathological antigen in GO.
- Published
- 2021
- Full Text
- View/download PDF
13. Proceedings of the 7th Biannual International Symposium on Nasopharyngeal Carcinoma 2015
- Author
-
Tan, IB, Chang, Ellen T., Chen, Chien-Jen, Hsu, Wan-Lun, Chien, Yin-Chu, Hildesheim, Allan, McKay, James D., Gaborieau, Valerie, Kaderi, Mohamed Arifin Bin, Purnomosari, Dewajani, Voegele, Catherine, LeCalvez-Kelm, Florence, Byrnes, Graham, Brennan, Paul, Devi, Beena, Li, L., Zhang, Y., Fan, Y., Sun, K., Du, Z., Sun, H., Chan, A. T., Tsao, S. W., Zeng, Y. X., Tao, Q., Busson, Pierre, Lhuillier, Claire, Morales, Olivier, Mrizak, Dhafer, Gelin, Aurore, Kapetanakis, Nikiforos, Delhem, Nadira, Mansouri, Sheila, Cao, Jennifer, Vaidya, Anup, Frappier, Lori, Wai, Lo Kwok, Chen, Sui-Hong, Du, Jin-lin, Ji, Ming-Fang, Huang, Qi-Hong, Liu, Qing, Cao, Su-Mei, Doolan, Denise L., Coghill, Anna, Mulvenna, Jason, Proietti, Carla, Lekieffre, Lea, Bethony, Jeffrey, Hildesheim, and Allan, Fles, Renske, Indrasari, Sagung Rai, Herdini, Camelia, Martini, Santi, Isfandiari, Atoillah, Rhomdoni, Achmad, Adham, Marlinda, Mayangsari, Ika, van Werkhoven, Erik, Wildeman, Maarten, Hariwiyanto, Bambang, Hermani, Bambang, Kentjono, Widodo Ario, Haryana, Sofia Mubarika, Schmidt, Marjanka, O’Sullivan, Brian, Ozyar, Enis, Lee, Anne W. M., Zeng, Mu-Sheng, Gao, Xiaojiang, Tang, Minzhong, Martin, Pat, Zeng, Yi, Carrington, Mary, Coghill, Anna E., Bu, Wei, Nguyen, Hanh, Yu, Kelly J., Lou, Pei-Jen, Wang, Cheng-Ping, Cohen, Jeffrey I., King, Ann D., Chen, Tseng-Cheng, Lin, Ching-Yuan, Tsou, Yung-An, Leu, Yi-Shing, Laio, Li-Jen, Chang, Yen-Liang, Hua, Chun-Hun, Wu, Ming-Shiang, Hsiao, Chu-Hsing Kate, Lee, Jehn-Chuan, Tsai, Ming-Hsui, Cheng, Skye Hung-Chun, Liao, Li-Jen, Yang, Tsung-Lin, Ko, Jenq-Yuh, Ko, Josephine Mun Yee, Dai, Wei, Kwong, Dora, Ng, Wai Tong, Lee, Anne, Ngan, Roger Kai Cheong, Yau, Chun Chung, Tung, Stewart, Lung, Maria Li, Ji, Mingfang, Sheng, Wei, Ng, Mun Hon, Cheng, Weimin, Yu, Xia, Wu, Biaohua, Wei, Kuangrong, Zhan, Jun, Zeng, Yi Xin, Cao, Su Mei, Xia, Ningshao, Yuan, Yong, Cui, Qian, Xu, Miao, Bei, Jin-Xin, Zeng, Yi-Xin, Şahin, B, Dizman, A, Esassolak, M, İkizler, A Saran, Yıldırım, HC, Çaloğlu, M, Atalar, B, Akman, F, Demiroz, C, Atasoy, BM, Canyilmaz, E, Igdem, S, Ugurluer, G, Kütük, T, Akmansoy, M, Ozyar, E, Sommat, Kiattisa, Wang, Fu Qiang, Kwok, Li-Lian, Tan, Terence, Fong, Kam Weng, Soong, Yoke Lim, Cheah, Shie Lee, Wee, Joseph, Casanova, M, Özyar, E, Patte, C, Orbach, D, Ferrari, A, Cristine, VF, Errihani, H, Pan, J, Zhang, L, Liji, S, Grzegorzewski, K, Gore, L, Varan, A, Hutajulu, Susanna Hilda, Khuzairi, Guntara, Kusumo, Henry, Hardianti, Mardiah Suci, Taroeno-Hariadi, Kartika Widayati, Purwanto, Ibnu, Kurnianda, Johan, Messick, Troy E., Malecka, Kimberly, Tolvinski, Lois, Soldan, Samantha, Deakyne, Julianna, Song, Hui, van den Heuvel, Antonio, Gu, Baiwei, Cassel, Joel, McDonnell, Mark, Smith, Garry R., Velvadapu, Venkata, Bian, Haiyan, Zhang, Yan, Carlsen, Marianne, Chen, Shuai, Donald, Alastair, Lemmen, Christian, Reitz, Allen B., Lieberman, Paul M., Chan, King Chi, Chan, Lai Sheung, Lo, Kwok Wai, Yip, Timothy Tak Chun, Kahn, Michael, Mak, Nai Ki, Liu, Fei-Fei, Khaali, Wafa, Thariat, Juliette, Fantin, Laurence, Spirito, Flavia, Khyatti, Meriem, Driss, El Khalil Ben, Olivero, Sylvain, Maryanski, Janet, Doglio, Alain, Xia, Mengxue, Xia, Yunfei, Chang, Hui, Shaw, Rachel, Rahaju, Pudji, Wisesa, Sindhu, Taroeno-Harijadi, Kartika Widayati, Dhamiyati, Wigati, Tan, Sang-Nee, Sim, Sai-Peng, Yusuf, Muhtarum, Romdhoni, Ahmad C., K, Widodo Ario, Rantam, Fedik Abdul, Sugiyanto, Aryati, Lina, Adi-Kusumo, Fajar, Bintoro, SY, Oktriani, R., Herawati, C., Surono, A., Haryana, Sofia M., Zhong, L., Ma, B. B., Kalra, M., Ngo, M., Perna, S., Leen, A., Lapteva, N., Rooney, C. M., Gottschalk, S., Mustikaningtyas, Elida, Herawati, Sri, Romdhoni, Achmad C., Xu, Yarui, Ge, Shengxiang, Li, Fugui, Ng, M. H., Tan, Louise SY, Wong, Benjamin, Lim, C. M., Rantam, Fedik A., Madani, Deasy Z., Akbar, Nur, Permana, Agung Dinasti, Fachiroh, Jajah, Hartati, Dwi, Rahayudjati, T. Baning, Darwis, Iswandi, Anwar, Khoirul, Dwidanarti, Sri Retna, Pramana, Dominicus Wendhy, Safitri, Diah Ari, Danarti, Sri Retna Dwi, Taroeno, Suryo A, Wijaya, I., Oehadian, A., Prasetya, D., Yu, Kelly J, Rahman, Sukri, Budiman, Bestari J., Novialdi, Rahmadona, Lestari, Dewi Yuri, Yin, C., Foussadier, A., Blein, E., Chen, C., Ammour, N. Bournet, Khiatti, M., Cao, S., Marzaini, Dewi Syafriyetti Soeis, Rahayujati, Baning, Gunawan, L., Mubarika Haryana, S., Hartono, Michael, Intansari, Umi, Paramita, Dewi Kartikawati, Akbar, Akmal, Hermawan, Benny, Paramita, Dewi K., Argy, Gabriella, Sihotang, Theodora Caroline, Wahyono, Daniel Joko, Soeharso, Purnomo, Suryandari, Dwi Anita, Lisnawati, Musa, Zanil, Daker, Maelinda, Tzen, Yeo Jiun, Bakar, Norhasimah, Rahman, Asma’ Saiyidatina Aishah Abdul, Ahmad, Munirah, Chia, Yeo Tiong, Beng, Alan Khoo Soo, Sasikirana, Widyandani, Wardana, Tirta, Radifar, Muhammad, Herawati, Cita, Surono, Agus, and Çocuk Sağlığı ve Hastalıkları
- Subjects
Meeting Abstracts - Abstract
A1 Hope and despair in the current treatment of nasopharyngeal cancer, IB Tan, I1 NPC international incidence and risk factors, Ellen T Chang, I2 Familial nasopharyngeal carcinoma and the use of biomarkers, Chien-Jen Chen, Wan-Lun Hsu, Yin-Chu Chien, I3 Genetic susceptibility risk factors for sporadic and familial NPC: recent findings, Allan Hildesheim, I5 Genetic and environmental risk factors for nasopharyngeal cancer in Southeast Asia, James D McKay, Valerie Gaborieau, Mohamed Arifin Bin Kaderi, Dewajani Purnomosari, Catherine Voegele, Florence LeCalvez-Kelm, Graham Byrnes, Paul Brennan, Beena Devi, I6 Characterization of the NPC methylome identifies aberrant epigenetic disruption of key signaling pathways and EBV-induced gene methylation, Li L, Zhang Y, Fan Y, Sun K, Du Z, Sun H, Chan AT, Tsao SW, Zeng YX, Tao Q, I7 Tumor exosomes and translational research in NPC, Pierre Busson, Claire Lhuillier, Olivier Morales, Dhafer Mrizak, Aurore Gelin, Nikiforos Kapetanakis, Nadira Delhem, I8 Host manipulations of the Epstein-Barr virus EBNA1 protein, Sheila Mansouri, Jennifer Cao, Anup Vaidya, and Lori Frappier, I9 Somatic genetic changes in EBV-associated nasopharyngeal carcinoma, Lo Kwok Wai, I10 Preliminary screening results for nasopharyngeal carcinoma with ELISA-based EBV antibodies in Southern China, Sui-Hong Chen, Jin-lin Du, Ming-Fang Ji, Qi-Hong Huang, Qing Liu, Su-Mei Cao, I11 EBV array platform to screen for EBV antibodies associated with NPC and other EBV-associated disorders, Denise L. Doolan, Anna Coghill, Jason Mulvenna, Carla Proietti, Lea Lekieffre, Jeffrey Bethony, and Allan Hildesheim, I12 The nasopharyngeal carcinoma awareness program in Indonesia, Renske Fles, Sagung Rai Indrasari, Camelia Herdini, Santi Martini, Atoillah Isfandiari, Achmad Rhomdoni, Marlinda Adham, Ika Mayangsari, Erik van Werkhoven, Maarten Wildeman, Bambang Hariwiyanto, Bambang Hermani, Widodo Ario Kentjono, Sofia Mubarika Haryana, Marjanka Schmidt, IB Tan, I13 Current advances and future direction in nasopharyngeal cancer management, Brian O’Sullivan, I14 Management of juvenile nasopharyngeal cancer, Enis Ozyar, I15 Global pattern of nasopharyngeal cancer: correlation of outcome with access to radiotherapy, Anne WM Lee, I16 The predictive/prognostic biomarker for nasopharyngeal carcinoma, Mu-Sheng Zeng, I17 Effect of HLA and KIR polymorphism on NPC risk, Xiaojiang Gao, Minzhong Tang, Pat Martin, Yi Zeng, Mary Carrington, I18 Exploring the Association between Potentially Neutralizing Antibodies against EBV Infection and Nasopharyngeal Carcinoma, Anna E Coghill, Wei Bu, Hanh Nguyen, Wan-Lun Hsu, Kelly J Yu, Pei-Jen Lou, Cheng-Ping Wang, Chien-Jen Chen, Allan Hildesheim, Jeffrey I Cohen, I19 Advances in MR imaging in NPC, Ann D King, O1 Epstein-Barr virus seromarkers and risk of nasopharyngeal carcinoma: the gene-environment interaction study on nasopharyngeal carcinoma in Taiwan, Yin-Chu Chien, Wan-Lun Hsu, Kelly J Yu, Tseng-Cheng Chen, Ching-Yuan Lin, Yung-An Tsou, Yi-Shing Leu, Li-Jen Laio, Yen-Liang Chang, Cheng-Ping Wang, Chun-Hun Hua, Ming-Shiang Wu, Chu-Hsing Kate Hsiao, Jehn-Chuan Lee, Ming-Hsui Tsai, Skye Hung-Chun Cheng, Pei-Jen Lou, Allan Hildesheim, Chien-Jen Chen, O2 Familial tendency and environmental co-factors of nasopharyngeal carcinoma: the gene-environment interaction study on nasopharyngeal carcinoma in Taiwan, Wan-Lun Hsu, Kelly J Yu, Yin-Chu Chien, Tseng-Cheng Chen, Ching-Yuan Lin, Yung-An Tsou, Yi-Shing Leu, Li-Jen Liao, Yen-Liang Chang, Tsung-Lin Yang, Chun-Hun Hua, Ming-ShiangWu, Chu-Hsing Kate Hsiao, Jehn-ChuanLee, Ming-Hsui Tsai, Skye Hung-Chun Cheng, Jenq-Yuh Ko, Allan Hildesheim, Chien-Jen Chen, O3 The genetic susceptibility and prognostic role of TERT-CLPTM1L and genes in DNA damage pathways in NPC, Josephine Mun Yee Ko, Wei Dai, Dora Kwong, Wai Tong Ng, Anne Lee, Roger Kai Cheong Ngan, Chun Chung Yau, Stewart Tung, Maria Li Lung, O4 Long term effects of NPC screening, Mingfang Ji, Wei Sheng, Mun Hon Ng, Weimin Cheng, Xia Yu, Biaohua Wu, Kuangrong Wei, Jun Zhan, Yi Xin Zeng, Su Mei Cao, Ningshao Xia, Yong Yuan, O5 Risk prediction of nasopharyngeal carcinoma by detecting host genetic and Epstein-Barr virus variation in saliva, Qian Cui, Miao Xu, Jin-Xin Bei, Yi-Xin Zeng, O6 Patterns of care study in Turkish nasopharyngeal cancer patients (NAZOTURK): A Turkish Radiation Oncology Association Head and Neck Cancer Working Group Study, B Şahin, A Dizman, M Esassolak, A Saran İkizler, HC Yıldırım, M Çaloğlu, B Atalar, F Akman, C Demiroz, BM Atasoy, E Canyilmaz, S Igdem, G Ugurluer, T Kütük, M Akmansoy, E Ozyar, O7 Long term outcome of intensity modulated radiotherapy in nasopharyngeal carcinoma in National Cancer Centre Singapore, Kiattisa Sommat, Fu Qiang Wang, Li-Lian Kwok, Terence Tan, Kam Weng Fong, Yoke Lim Soong, Shie Lee Cheah, Joseph Wee, O8 International phase II randomized study on the addition of docetaxel to the combination of cisplatin and 5-fluorouracil in the induction treatment for nasopharyngeal carcinoma in children and adolescents, M Casanova, E Özyar, C Patte, D Orbach, A Ferrari, VF Cristine, H Errihani, J Pan, L Zhang, S Liji, K Grzegorzewski, L Gore, A Varan, O9 Prognostic impact of metastatic status in patients with nasopharyngeal carcinoma, Susanna Hilda Hutajulu, Guntara Khuzairi, Camelia Herdini, Henry Kusumo, Mardiah Suci Hardianti, Kartika Widayati Taroeno-Hariadi, Ibnu Purwanto, Johan Kurnianda, O10 Development of small molecule inhibitors of latent Epstein-Barr virus infection for the treatment of nasopharyngeal carcinoma, Troy E. Messick, Kimberly Malecka, Lois Tolvinski, Samantha Soldan, Julianna Deakyne, Hui Song, Antonio van den Heuvel, Baiwei Gu, Joel Cassel, Mark McDonnell, Garry R Smith, Venkata Velvadapu, Haiyan Bian, Yan Zhang, Marianne Carlsen, Shuai Chen, Alastair Donald, Christian Lemmen, Allen B Reitz, Paul M Lieberman, O11 Therapeutic targeting of cancer stem-like cells using a Wnt modulator, ICG-001, enhances the treatment outcome of EBV-positive nasopharyngeal carcinoma, King Chi Chan, Lai Sheung Chan, Kwok Wai Lo, Timothy Tak Chun Yip, Roger Kai Cheong Ngan, Michael Kahn, Maria Li Lung, Nai Ki Mak, O12 Role of micro-RNA in NPC biology, Fei-Fei Liu, O13 Expansion of EBNA1- and LMP2-specific effector T lymphocytes from patients with nasopharyngeal carcinoma without enhancement of regulatory T cells, Wafa Khaali; Juliette Thariat; Laurence Fantin; Flavia Spirito; Meriem Khyatti; El Khalil Ben Driss; Sylvain Olivero; Janet Maryanski; Alain Doglio, O14 The experience of patients’ life after amifostine radiotherapy treatment (ART) for nasopharyngeal carcinoma (NPC), Mengxue Xia, Yunfei Xia, Hui Chang, Rachel Shaw, O15 Analysis of mitochondrial DNA mutation in latent membrane protein-1 positive nasopharyngeal carcinoma, Pudji Rahaju, O16 Factors influencing treatment adherence of nasopharyngeal cancer and the clinical outcomes: a hospital-based study, Mardiah Suci Hardianti, Sindhu Wisesa, Kartika Widayati Taroeno-Harijadi, Ibnu Purwanto, Bambang Hariwiyanto, Wigati Dhamiyati, Johan Kurnianda, O17 Chromosomal breaks mediated by bile acid-induced apoptosis in nasopharyngeal epithelial cells: in relation to matrix association region/scaffold attachment region, Sang-Nee Tan, Sai-Peng Sim, O18 Expression of p53 (wild type) on nasopharyngeal carcinoma stem cell that resistant to radiotherapy, Muhtarum Yusuf, Ahmad C Romdhoni, Widodo Ario K, Fedik Abdul Rantam, O19 Mathematical model of nasopharyngeal carcinoma in cellular level, Sugiyanto, Lina Aryati, Fajar Adi-Kusumo, Mardiah Suci Hardianti, O20 Differential expression of microRNA-21 on nasopharyngeal carcinoma plasma patient, SY Bintoro, R Oktriani, C. Herawati, A Surono, Sofia M. Haryana, O21 Therapeutic targeting of an oncogenic fibroblast growth factor-FGF19, which promotes proliferation and induces EMT of carcinoma cells through activating ERK and AKT signaling, L. Zhong, L. Li, B. B. Ma, A. T. Chan, Q. Tao, O22 Resist nasopharyngeal carcinoma (NPC): next generation T cells for the adoptive immunotherapy of NPC, M. Kalra, M. Ngo, S. Perna, A. Leen, N. Lapteva, C. M. Rooney, S. Gottschalk, O23 The correlation of heat shock protein 70 expressions and staging of nasopharyngeal carcinoma, Elida Mustikaningtyas, Sri Herawati, Achmad C Romdhoni, O24 Epstein-Barr virus serological profiles of nasopharyngeal carcinoma - A tribute to Werner Henle, Mingfang Ji, YaruiXu, Weimin Cheng, ShengxiangGe, Fugui Li, M. H. Ng, O25 Targeting the apoptosis pathway using combination TLR3 agonist with anti-survivin molecule (YM-155) in nasopharyngeal carcinoma, Louise SY Tan, Benjamin Wong, CM Lim, O26 The resistance mechanism of nasopharyngeal cancer stem cells to cisplatin through expression of CD44, Hsp70, p53 (wild type), Oct-4, and ß-catenin encoded-genes, Achmad C Romdhoni, Fedik A. Rantam, Widodo Ario Kentjono, P1 Prevalence of nasopharyngeal carcinoma patients at Departement of Otorhinolaringology-Head and Neck Surgery, Dr. Hasan Sadikin general hospital, Bandung, Indonesia in 2010-2014, Deasy Z Madani, Nur Akbar, Agung Dinasti Permana, P2 Case report on pediatric nasopharyngeal carcinoma at Dr. Sardjito Hospital, Yogyakarta, Camelia Herdini, Sagung Rai Indrasari, Jajah Fachiroh, Dwi Hartati, T. Baning Rahayudjati, P3 Report on loco regionally advanced nasopharyngeal cancer patients treated with induction chemotherapy followed by concurrent chemo-radiation therapy, Iswandi Darwis, Susanna Hilda Hutajulu, Bambang Hariwiyanto, Wigati Dhamiyati, Ibnu Purwanto, Kartika Widayati Taroeno-Hariadi, Johan Kurnianda, P4 Sex and age differences in the survival of patients with nasopharyngeal carcinoma, Sindhu Wisesa, Mardiah Suci Hardianti, Susanna Hilda Hutajulu, Kartika Widayati Taroeno-Harijadi, Ibnu Purwanto, Camelia Herdini, Wigati Dhamiyati, Johan Kurnianda, P5 Impact of delayed diagnosis and delayed therapy in the treatment outcome of patients with nasopharyngeal carcinoma, Khoirul Anwar, Susanna Hilda Hutajulu, Sagung Rai Indrasari, Sri Retna Dwidanarti, Ibnu Purwanto, Kartika Widayati Taroeno-Hariadi, Johan Kurnianda, P6 Anaysis of pretreatment anemia in nasopharyngeal cancer patients undergoing neoadjuvant therapy, Dominicus Wendhy Pramana, Susanna Hilda Hutajulu, Bambang Hariwiyanto, Wigati Dhamiyati, Ibnu Purwanto, Kartika Widayati Taroeno-Hariadi, Johan Kurnianda, P7 Results of treatment with neoadjuvant cisplatin-5FU in locally advanced nasopharyngeal carcinoma: a local experience, Diah Ari Safitri, Susanna Hilda Hutajulu, Camelia Herdini, Sri Retna Dwi Danarti, Ibnu Purwanto, Kartika Widayati Taroeno-Hariadi, Johan Kurnianda, P8 Geriatrics with nasopharyngeal cancer, Suryo A Taroeno, Sindhu Wisesa, Kartika Widayati Taroeno-Hariadi, Ibnu Purwanto, Bambang Hariwiyanto, Wigati Dhamiyati, Johan Kurnianda, P9 Correlation of lymphocyte to monocyte and neutrophil to lymphocyte ratio to the response of cisplatin chemoradiotheraphy in locally advance nasopharyngeal carcinoma, I. Wijaya, A. Oehadian, D. Prasetya, P10 Prediction of nasopharyngeal carcinoma risk by Epstein-Barr virus seromarkers and environmental co-factors: the gene-environment interaction study on nasopharyngeal carcinoma in Taiwan, Wan-Lun Hsu, Yin-Chu Chien, Kelly J Yu, Cheng-Ping Wang, Ching-Yuan Lin, Yung-An Tsou, Yi-Shing Leu, Li-Jen Liao, Yen-Liang Chang191,192, Jenq-Yuh Ko, Chun-Hun Hua, Ming-Shiang Wu, Chu-Hsing Kate Hsiao, Jehn-Chuan Lee, Ming-Hsui Tsai, Skye Hung-Chun Cheng, Pei-Jen Lou, Allan Hildesheim, Chien-Jen Chen, P11 Non-viral risk factors for nasopharyngeal carcinoma in West Sumatra, Indonesia, Sukri Rahman, Bestari J. Budiman, Novialdi, Rahmadona, Dewi Yuri Lestari, P12 New prototype Vidas EBV IgA quick: performance on Chinese and Moroccan populations, C. Yin, A. Foussadier, E. Blein, C. Chen, N. Bournet Ammour, M. Khiatti, S. Cao, P13 The expression of EBV-LMP1 and VEGF as predictors and plasma EBV-DNA levels as early marker of distant metastasis after therapy in nasopharyngeal cancer, Dewi Syafriyetti Soeis Marzaini, P14 Characteristics and factors influencing subjects refusal for blood samples retrieval: lesson from NPC case control study in Yogyakarta – Indonesia, Dwi Hartati, Baning Rahayujati, Camelia Herdini, Jajah Fachiroh, P15 Expression of microRNA BART-7-3p and mRNA PTEN on blood plasma of patients with nasopharyngeal carcinoma, L. Gunawan, S. Mubarika Haryana, A. Surono, C. Herawati, P16 IgA response to native early antigen (IgA-EAext) of Epstein-Barr virus (EBV) in healthy population and nasopharyngeal carcinoma (NPC) patients: the potential for diagnosis and screening tools, Michael Hartono, Jajah Fachiroh, Umi Intansari, Dewi Kartikawati Paramita, P17 IgA responses against Epstein-Barr Virus Early Antigen (EBV-EA) peptides as potential candidates of nasopharyngeal carcinoma detection marker, Akmal Akbar, Jajah Fachiroh, Dewi Kartikawati Paramita, P18 Association between smoking habit and IgA-EBV titer among healthy individuals in Yogyakarta, Indonesia, Benny Hermawan, T Baning Rahayudjati, Dewi K Paramita, Jajah Fachiroh, P19 Epstein-Barr virus IgA titer comparison of healthy non-family individuals and healthy first degree family of NPV patients, Gabriella Argy, Jajah Fachiroh, Dewi Kartikawati Paramita, Susanna Hilda Hutajulu, P20 Identification of EBV Early Antigen (EA) derived peptides for NPC diagnosis, Theodora Caroline Sihotang, Jajah Fachiroh, Umi Intansari, Dewi Kartikawati Paramita, P21 Host-pathogen study: relative expression of mRNA BRLF1 Epstein-Barr virus as a potential biomarker for tumor progressivity and polymorphisms of TCRBC and TCRGC2 host genes related to genetic susceptibility on nasopharyngeal carcinoma, Daniel Joko Wahyono, Purnomo Soeharso, Dwi Anita Suryandari, Lisnawati, Zanil Musa, Bambang Hermani, P22 In vitro efficacy of silvestrol and episilvestrol, isolated from Borneo, on nasopharyngeal carcinoma, a major cancer in Borneo, Maelinda Daker, Yeo Jiun Tzen, Norhasimah Bakar, Asma’ Saiyidatina Aishah Abdul Rahman, Munirah Ahmad, Yeo Tiong Chia, Alan Khoo Soo Beng, P23 The expression of mir-141 in patients with nasopharyngeal cancer, Widyandani Sasikirana, Tirta Wardana, Muhammad Radifar, Cita Herawati, Agus Surono, Sofia Mubarika Haryana
- Published
- 2016
14. Prognostic Significance of Neutrophil to Lymphocyte Ratio, Lymphocyte to Monocyte Ratio, and Platelet to Lymphocyte Ratio in Patients with Nasopharyngeal Carcinoma
- Author
-
Lu, Aiying, primary, Li, Haifeng, additional, Zheng, Yuming, additional, Tang, Minzhong, additional, Li, Jun, additional, Wu, Huihui, additional, Zhong, Weiming, additional, Gao, Jianquan, additional, Ou, Ningjiang, additional, and Cai, Yonglin, additional
- Published
- 2017
- Full Text
- View/download PDF
15. Signal localization: a new approach in signal discovery
- Author
-
Malov, Sergey V., primary, Antonik, Alexey, additional, Tang, Minzhong, additional, Berred, Alexandre, additional, Zeng, Yi, additional, and O'Brien, Stephen J., additional
- Published
- 2016
- Full Text
- View/download PDF
16. Increased Serum Levels of Macrophage Inflammatory Protein-3α and Cystatin A Predict a Poor Prognosis of Nasopharyngeal Carcinoma
- Author
-
Yong-Lin Cai, Wei Wang, Tang Minzhong, Weiming Zhong, Jun Li, Yuming Zheng, Hong Zeng, Ai-Ying Lu, and Jianquan Gao
- Subjects
Adult ,Male ,medicine.medical_specialty ,Nasopharyngeal neoplasm ,Observational Study ,Gastroenterology ,Article ,Disease-Free Survival ,Young Adult ,Internal medicine ,Carcinoma ,Medicine ,Humans ,Cystatin A ,Prospective Studies ,Prospective cohort study ,Survival rate ,Macrophage inflammatory protein ,Survival analysis ,Aged ,Chemokine CCL20 ,Nasopharyngeal Carcinoma ,business.industry ,Nasopharyngeal Neoplasms ,General Medicine ,Middle Aged ,medicine.disease ,Prognosis ,Survival Rate ,Nasopharyngeal carcinoma ,Immunology ,Female ,business - Abstract
This study was aimed to investigate the roles of serum macrophage inflammatory protein-3α (MIP-3α) and cystatin A in nasopharyngeal carcinoma (NPC) prognosis. The serum levels of MIP-3α and cystatin A in 140 primary NPC patients without distant metastasis were detected by enzyme-linked immunosorbent assay before and after treatment. The results were compared with those in 100 healthy controls. The log-rank test was used to compare survival curves of the 2 groups. Multivariate analysis of prognostic factors used Cox proportional hazards regression model. Serum levels of MIP-3α and cystatin A in pretreatment patients with NPC were higher than those in healthy controls. Concentrations of these 2 factors in the majority of patients after the therapy decreased to control level. Patients with high serum level of MIP-3α and cystatin A before treatment had poorer overall survival (OS), local recurrence-free survival, and distant metastasis-free survival than the ones with low level. In addition, serum pretreatment MIP-3α and cystatin A levels were independent prognostic factors for OS and distant metastasis-free survival of NPC patients; serum posttreatment MIP-3α and cystatin A levels were independent prognostic factors of local recurrence-free survival. Our results revealed that serum MIP-3α and cystatin A may be promising candidate prognostic factors for NPC, and higher serum levels of MIP-3α and cystatin A correlate with shorter probability of OS, local recurrence, and distant metastasis.
- Published
- 2014
17. Technology Revolution of HLA Typing
- Author
-
Jun Li, Tang Minzhong, Yong-Lin Cai, Huang Yulu, and Yuming Zheng
- Subjects
Genetics ,Chromosome ,Human genome ,Human leukocyte antigen ,Biology ,Omics ,Gene - Abstract
The human leukocyte antigen (HLA) region is the most polymorphic in the human genome, which located on the chromosome 6p21 encodes more than 200 genes.
- Published
- 2014
18. Genetic association between HLA class I alleles and hepatitis B virus-related hepatocellular carcinoma in a southern Chinese population
- Author
-
Tang, Minzhong, primary, Zheng, Yuming, additional, Cai, Yonglin, additional, Gao, Xiaojiang, additional, Carrington, Mary, additional, and Peng, Tao, additional
- Published
- 2015
- Full Text
- View/download PDF
19. Compound HLA/KIR genotypes influence risk of nasopharyngeal carcinoma (NPC) in a southern chinese cohort
- Author
-
Gao, Xiaojiang, primary, Tang, Minzhong, additional, Martin, Pat, additional, Zeng, Yi, additional, and Carrington, Mary, additional
- Published
- 2015
- Full Text
- View/download PDF
20. Expression and Prognostic Significance of Macrophage Inflammatory Protein-3 Alpha and Cystatin A in Nasopharyngeal Carcinoma
- Author
-
Tang, Minzhong, primary, Ou, Ningjiang, additional, Li, Cheng, additional, Lu, Aiying, additional, Li, Jun, additional, Ma, Liping, additional, Zhong, Weiming, additional, Gao, Jianquan, additional, Zheng, Yuming, additional, and Cai, Yonglin, additional
- Published
- 2015
- Full Text
- View/download PDF
21. Increased Serum Levels of Macrophage Inflammatory Protein-3α and Cystatin A Predict a Poor Prognosis of Nasopharyngeal Carcinoma
- Author
-
Cai, Yonglin, primary, Li, Jun, additional, Lu, Aiying, additional, Zhong, Weiming, additional, Gao, Jianquan, additional, Zheng, Yuming, additional, Zeng, Hong, additional, Wang, Wei, additional, and Tang, Minzhong, additional
- Published
- 2014
- Full Text
- View/download PDF
22. Signal localization: a new approach in signal discovery.
- Author
-
Malov, Sergey V., Antonik, Alexey, Tang, Minzhong, Berred, Alexandre, Zeng, Yi, and O'Brien, Stephen J.
- Abstract
A new approach for statistical association signal identification is developed in this paper. We consider a strategy for nonprecise signal identification by extending the well-known signal detection and signal identification methods applicable to the multiple testing problem. Collection of statistical instruments under the presented approach is much broader than under the traditional signal identification methods, allowing more efficient signal discovery. Further assessments of maximal value and average statistics in signal discovery are improved. While our method does not attempt to detect individual predictors, it instead detects sets of predictors that are jointly associated with the outcome. Therefore, an important application would be in genome wide association study (GWAS), where it can be used to detect genes which influence the phenotype but do not contain any individually significant single nucleotide polymorphism (SNP). We compare power of the signal identification method based on extremes of single p-values with the signal localization method based on average statistics for logarithms of p-values. A simulation analysis informs the application of signal localization using the average statistics for wide signals discovery in Gaussian white noise process. We apply average statistics and the localization method to GWAS to discover better gene influences of regulating loci in a Chinese cohort developed for risk of nasopharyngeal carcinoma (NPC). [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
23. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China
- Author
-
Guo, Xiuchan, primary, Winkler, Cheryl A., additional, Li, Ji, additional, Guan, Li, additional, Tang, Minzhong, additional, Liao, Jian, additional, Deng, Hong, additional, de Thé, Guy, additional, Zeng, Yi, additional, and O’Brien, Stephen J., additional
- Published
- 2014
- Full Text
- View/download PDF
24. The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve the HLA Class I Antigen Recognition Groove
- Author
-
Tang, Minzhong, primary, Lautenberger, James A., additional, Gao, Xiaojiang, additional, Sezgin, Efe, additional, Hendrickson, Sher L., additional, Troyer, Jennifer L., additional, David, Victor A., additional, Guan, Li, additional, Mcintosh, Carl E., additional, Guo, Xiuchan, additional, Zheng, Yuming, additional, Liao, Jian, additional, Deng, Hong, additional, Malasky, Michael, additional, Kessing, Bailey, additional, Winkler, Cheryl A., additional, Carrington, Mary, additional, dé The, Guy, additional, Zeng, Yi, additional, and O'Brien, Stephen J., additional
- Published
- 2012
- Full Text
- View/download PDF
25. Genome-Wide Association Study for Serum Complement C3 and C4 Levels in Healthy Chinese Subjects
- Author
-
Yang, Xiaobo, primary, Sun, Jielin, additional, Gao, Yong, additional, Tan, Aihua, additional, Zhang, Haiying, additional, Hu, Yanling, additional, Feng, Junjie, additional, Qin, Xue, additional, Tao, Sha, additional, Chen, Zhuo, additional, Kim, Seong-Tae, additional, Peng, Tao, additional, Liao, Ming, additional, Lin, Xiaoling, additional, Zhang, Zengfeng, additional, Tang, Minzhong, additional, Li, Li, additional, Mo, Linjian, additional, Liang, Zhengjia, additional, Shi, Deyi, additional, Huang, Zhang, additional, Huang, Xianghua, additional, Liu, Ming, additional, Liu, Qian, additional, Zhang, Shijun, additional, Trent, Jeffrey M., additional, Zheng, S. Lilly, additional, Xu, Jianfeng, additional, and Mo, Zengnan, additional
- Published
- 2012
- Full Text
- View/download PDF
26. F5 The Principal Genetic Determinants for Nasopharyngeal Carcinoma in China Involve HLA Class I Antigen Recognition Groove
- Author
-
Tang Minzhong, James A. Lautenberger, Xiaojiang Gao, Efe Sezgin, Sher L. Hendrickson, Jennifer L. Troyer, Victor A. David, Li Guan, Carl E. Mcintosh, Marilyn Raymond, Xiuchan Guo, Yuming Zheng, Jian Liao, Hong Deng, Michael Malasky, Joan Pontius, Bailey Kessing, Mary Carrington, Guy dé The, Yi Zeng, and Stephen J. O'Brien
- Subjects
Infectious Diseases ,Nasopharyngeal carcinoma ,Immunology ,medicine ,Pharmacology (medical) ,HLA class I antigen ,Biology ,medicine.disease ,Groove (joinery) ,Virology - Published
- 2012
27. Polygenic risk-stratified screening for nasopharyngeal carcinoma in high-risk endemic areas of China: a cost-effectiveness study.
- Author
-
Yang DW, Miller JA, Xue WQ, Tang M, Lei L, Zheng Y, Diao H, Wang TM, Liao Y, Wu YX, Zheng XH, Zhou T, Li XZ, Zhang PF, Chen XY, Yu X, Li F, Ji M, Sun Y, He YQ, and Jia WH
- Subjects
- Humans, China epidemiology, Middle Aged, Male, Adult, Female, Aged, Nasopharyngeal Neoplasms diagnosis, Early Detection of Cancer economics, Mass Screening economics, Multifactorial Inheritance, Risk Factors, Risk Assessment, Cost-Benefit Analysis, Nasopharyngeal Carcinoma diagnosis, Nasopharyngeal Carcinoma genetics, Markov Chains
- Abstract
Background: Nasopharyngeal carcinoma (NPC) has an extremely high incidence rate in Southern China, resulting in a severe disease burden for the local population. Current EBV serologic screening is limited by false positives, and there is opportunity to integrate polygenic risk scores for personalized screening which may enhance cost-effectiveness and resource utilization., Methods: A Markov model was developed based on epidemiological and genetic data specific to endemic areas of China, and further compared polygenic risk-stratified screening [subjects with a 10-year absolute risk (AR) greater than a threshold risk underwent EBV serological screening] to age-based screening (EBV serological screening for all subjects). For each initial screening age (30-34, 35-39, 40-44, 45-49, 50-54, 55-59, 60-64, and 65-69 years), a modeled cohort of 100,000 participants was screened until age 69, and then followed until age 79., Results: Among subjects aged 30 to 54 years, polygenic risk-stratified screening strategies were more cost-effective than age-based screening strategies, and almost comprised the cost-effectiveness efficiency frontier. For men, screening strategies with a 1-year frequency and a 10-year absolute risk (AR) threshold of 0.7% or higher were cost-effective, with an incremental cost-effectiveness ratio (ICER) below the willingness to pay (¥203,810, twice the local per capita GDP). Specifically, the strategies with a 10-year AR threshold of 0.7% or 0.8% are the most cost-effective strategies, with an ICER ranging from ¥159,752 to ¥201,738 compared to lower-cost non-dominated strategies on the cost-effectiveness frontiers. The optimal strategies have a higher probability (29.4-35.8%) of being cost-effective compared to other strategies on the frontier. Additionally, they reduce the need for nasopharyngoscopies by 5.1-27.7% compared to optimal age-based strategies. Likewise, for women aged 30-54 years, the optimal strategy with a 0.3% threshold showed similar results. Among subjects aged 55 to 69 years, age-based screening strategies were more cost-effective for men, while no screening may be preferred for women., Conclusion: Our economic evaluation found that the polygenic risk-stratified screening could improve the cost-effectiveness among individuals aged 30-54, providing valuable guidance for NPC prevention and control policies in endemic areas of China., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Yang, Miller, Xue, Tang, Lei, Zheng, Diao, Wang, Liao, Wu, Zheng, Zhou, Li, Zhang, Chen, Yu, Li, Ji, Sun, He and Jia.)
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.