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Objective To evaluate the clinical efficacy of Mulligan mobilization with movement （MWM） technique combined with dynamic interference electrotherapy in the treatment of cervical spondylosis. Methods A total of 42 patients with cervical spondylosis were retrospectively selected and divided into the observation group （MWM combined with dynamic interference electrotherapy, n = 21） and control group （dynamic interference electrotherapy only, n = 21）. The visual analogue scale （VAS）, neck disability index （NDI）, Hamilton anxiety scale （HAMA） and Pittsburgh sleep quality index （PSQI） scores before treatment, at the end of treatment, at 1 and 3 months after treatment were all compared between two groups. Results In two groups, all parameters at different time points after corresponding treatment were significantly improved compared with those before treatment （all P < 0.05）. The VAS score at the end of treatment in the observation group was significantly lower than that in the control group （P < 0.05）. In the observation group, the HAMA scores at the end of treatment, at 1 and 3 months after treatment were significantly lower, and the PSQI score was significantly lower compared with those in the control group （all P < 0.05）. Conclusion In addition to relieving neck pain and improving cervical spine function, MWM combined with dynamic interference electrotherapy can also alleviate anxiety and enhance sleep quality in patients with cervical spondylosis.

Carrier transport and recombination at the buried interface of perovskite have seriously restricted the further development of inverted perovskite solar cells (PSCs). Herein, an interfacial dipolar chemical bridge strategy to address this issue is presented. 2-(Diphenylphosphino) acetic acid (2DPAA) is selected as the linker to reconstruct the interfacial dipole, which effectively enlarges the interfacial dipole moment to 5.10 D and optimizes to a positive dipole orientation, thereby accelerating vertical hole transport, suppressing nonradiative recombination and promoting the perovskite crystallization. The champion inverted device yields a high power conversion efficiency (PCE) of 26.53% (certified 26.02%). Moreover, this strategy is extended to the wide-bandgap perovskite and large-area devices, which delivers high PCEs of 22.02% and 24.11%, respectively. The optimized devices without encapsulation also demonstrate great long-term shelf and operational stability. Our work highlights the importance of interfacial dipole moment and orientation at the buried interface to realize efficient and stable inverted PSCs. Carrier transport and recombination at the buried interface have hindered the development of inverted perovskite solar cells. Here, the authors employ a linker to reconstruct interfacial dipole, achieving maximum efficiency of 26.53% and 24.11% for small- and large-area devices, respectively. [ABSTRACT FROM AUTHOR]

When initiating public interest litigation, the procuratorates often face the dilemma of choosing between the model of administrative public interest litigation (APIL) and the model of civil public interest litigation (CPIL). However, only choosing either model has flaws and shortcomings. Both CPIL incidental to criminal action and that incidental to administrative action are also faced with many confusions and difficulties in concepts and implementation mechanisms. Given the direction of progress, the procuratorates should integrate the inherent institutional advantages of the model of APIL and the model of CPIL to develop an integrated model of procuratorial public interest litigation (PPIL) characterized by oneness and integrity. To this end, revising the dual legislative separation, where the Civil Procedure Law of the People’s Republic of China and the Administrative Litigation Law of the People’s Republic of China separately regulate public interest litigation, is necessary. Formulating a unified “Public Interest Litigation Law” or “Procuratorial Public Interest Litigation Law” to establish an integrated PPIL model has become an inevitable trend. [ABSTRACT FROM AUTHOR]

Non-Small Cell Lung Cancer (NSCLC) is a prevalent and deadly form of lung cancer worldwide with a low 5-year survival rate. Current treatments have limitations, particularly for advanced-stage patients. P21, a protein that inhibits the CCND1-CDK4 complex, plays a crucial role in cell proliferation. Computer-Aided Drug Design (CADD) based on pharmacophores can screen and design PPI inhibitors targeting the CCND1-CDK4 complex. By analyzing known inhibitors, key pharmacophores are identified, and computational methods are used to screen potential PPI inhibitors. Molecular docking, pharmacophore matching, and structure-activity relationship studies optimize the inhibitors. This approach accelerates the discovery of CCND1-CDK4 PPI inhibitors for NSCLC treatment. Molecular dynamics simulations of CCND1-CDK4-P21 and CCND1-CDK4 complexes showed stable behavior, comprehensive sampling, and P21's impact on complex stability and hydrogen bond formation. A pharmacophore model facilitated virtual screening, identifying compounds with favorable binding affinities. Further simulations confirmed the stability and interactions of selected compounds, including 513457. This study demonstrates the potential of CADD in optimizing PPI inhibitors targeting the CCND1-CDK4 complex for NSCLC treatment. Extended simulations and experimental validations are necessary to assess their efficacy and safety. [ABSTRACT FROM AUTHOR]

Introduction: Cancer stem cells (CSCs) play critical roles in lung adenocarcinoma (LUAD) progression, and fatty acid oxidation is key for CSC growth and survival. Therefore, investigating the molecular mechanisms regulating fatty acid β-oxidation in LUAD is important for its treatment. Methods: Bioinformatics analysis assessed CPT1B and MITF expression and their correlation in LUAD tissues, as well as the pathways enriched by CPT1B. qRT-PCR assessed expression of CPT1B and MITF, while CCK-8 and sphere-forming assays were used to measure cell viability and stemness, respectively. Dual staining detected lipid accumulation, while kits were used to measure fatty acid β-oxidation and glycerol content. qRT-PCR was used to assay expression of lipid oxidation genes. Western blot was used to examine expression of stem cell-related markers. Dual-luciferase assay and ChIP assay were used to verify the binding relationship between MITF and CPT1B. Results: CPT1B was found to be highly expressed in LUAD and enriched in linoleic acid metabolism pathway and α-linolenic acid metabolism pathway. Functional experiments showed that CPT1B could promote stemness in LUAD cells by regulating fatty acid β-oxidation. Additionally, CPT1B was found to be regulated by the upstream transcription factor MITF, which was lowly expressed in LUAD and could downregulate CPT1B expression. Rescue experiments revealed that CPT1B/MITF axis could affect stemness in LUAD cells by regulating fatty acid β-oxidation. Conclusion: Transcription factor MITF inhibited transcription of CPT1B to regulate fatty acid β-oxidation, thereby suppressing stemness in LUAD cells. MITF and CPT1B may become new targets for LUAD. [ABSTRACT FROM AUTHOR]