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Abstract: As a generalization of the triple I method, differently implicational universal triple I method of (1, 2, 2) type (universal triple I method for short) is investigated. First, the concepts of residual operators and strongly residual operators are given, and then related conclusions of residual pairs are provided. Second, the related universal triple I solutions (including FMP-solutions, FMT-solutions and so on) are strictly defined by the infimum, where such solutions are divided into two parts respectively corresponding to the minimum and infimum. Then, we put emphasis on the FMP-solutions, in which the unified forms of FMP-solutions w.r.t. strongly residual operators and a new idea for getting FMP-solutions w.r.t. infimum are achieved. Third, as a result of analyzing the logic basis of a sort of CRI (Compositional Rule of Inference) method, it is found that their CRI solutions can be regarded as special cases of FMP-solutions. Lastly, the response functions of fuzzy systems via universal triple I method are discussed, which demonstrates that the universal triple I method can provide bigger choosing space and get better fuzzy controllers by contrast with the triple I method and CRI method. [Copyright &y& Elsevier]

A new technique for Peano fractal loaded monopole antenna to enhance impedance bandwidth by loading shorting pins is presented. Simulated and measured data show that relative impedance bandwidths of the proposed order 1 and order 2 antennas achieve 23 and 28% for VSWR less than 2 in L-band, which are enhanced 90 and 75% than those of conventional ones, respectively, while the profile and radiation patterns change little. © 2008 Wiley Periodicals, Inc. Microwave Opt Technol Lett 50: 2045–2048, 2008; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.23583 [ABSTRACT FROM AUTHOR]

The effect of a finite ground plane on Peano monopole antenna is investigated. Simulated and measured data indicate that when the size of ground plane decreases, impedance bandwidth and gain of the antenna will decrease, H-plane pattern will change little, 3-dB beam width will become wider and elevation angle will be smaller in E-plane. © 2007 Wiley Periodicals, Inc. Microwave Opt Technol Lett 49: 3087–3090, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.22891 [ABSTRACT FROM AUTHOR]

Background: Circular RNAs (circRNAs) have been indicated as potentially critical mediators in various types of tumor progression, generally acting as microRNA (miRNA) sponges to regulate downstream gene expression. However, the aberrant expression profile and dysfunction of circRNAs in human clear cell renal cell carcinoma (ccRCC) need to be further investigated. This study mined key prognostic circRNAs and elucidates the potential role and molecular mechanism of circRNAs in regulating the proliferation and metastasis of ccRCC. Methods: circCHST15 (hsa_circ_0020303) was identified by mining two circRNA microarrays from the Gene Expression Omnibus database and comparing matched tumor versus adjacent normal epithelial tissue pairs or matched primary versus metastatic tumor tissue pairs. These results were validated by quantitative real-time polymerase chain reaction and agarose gel electrophoresis. We demonstrated the biological effect of circCHST15 in ccRCC both in vitro and in vivo. To test the interaction between circCHST15 and miRNAs, we conducted a number of experiments, including RNA pull down assay, dual-luciferase reporter assay and fluorescence in situ hybridization. Results: The expression of circCHST15 was higher in ccRCC tissues compared to healthy adjacent kidney tissue and higher in RCC cell lines compared to normal kidney cell lines. The level of circCHST15 was positively correlated with aggressive clinicopathological characteristics, and circCHST15 served as an independent prognostic indicator for overall survival and progression-free survival in patients with ccRCC after surgical resection. Our in vivo and in vitro data indicate that circCHST15 promotes the proliferation, migration, and invasion of ccRCC cells. Mechanistically, we found that circCHST15 directly interacts with miR-125a-5p and acts as a microRNA sponge to regulate EIF4EBP1 expression. Conclusions: We found that sponging of miR-125a-5p to promote EIF4EBP1 expression is the underlying mechanism of hsa_circ_0020303-induced ccRCC progression. This prompts further investigation of circCHST15 as a potential prognostic biomarker and therapeutic target for ccRCC. [ABSTRACT FROM AUTHOR]

Increasing evidences show the clinical significance of the interaction between hypoxia and immune in clear cell renal cell carcinoma (ccRCC) microenvironment. However, reliable prognostic signatures based on a combination of hypoxia and immune have not been well established. Moreover, many studies have only used RNA-seq profiles to screen the prognosis feature of ccRCC. Presently, there is no comprehensive analysis of multiomics data to mine a better one. Thus, we try and get it. First, t-SNE and ssGSEA analysis were used to establish tumor subtypes related to hypoxia-immune, and we investigated the hypoxia-immune–related differences in three types of genetic or epigenetic characteristics (gene expression profiles, somatic mutation, and DNA methylation) by analyzing the multiomics data from The Cancer Genome Atlas (TCGA) portal. Additionally, a four-step strategy based on lasso regression and Cox regression was used to construct a satisfying prognostic model, with average 1-year, 3-year and 5-year areas under the curve (AUCs) equal to 0.806, 0.776 and 0.837. Comparing it with other nine known prognostic biomarkers and clinical prognostic scoring algorithms, the multiomics-based signature performs better. Then, we verified the gene expression differences in two external databases (ICGC and SYSU cohorts). Next, eight hub genes were singled out and seven hub genes were validated as prognostic genes in SYSU cohort. Furthermore, it was indicated high-risk patients have a better response for immunotherapy in immunophenoscore (IPS) analysis and TIDE algorithm. Meanwhile, estimated by GDSC and cMAP database, the high-risk patients showed sensitive responses to six chemotherapy drugs and six candidate small-molecule drugs. In summary, the signature can accurately predict the prognosis of ccRCC and may shed light on the development of novel hypoxia-immune biomarkers and target therapy of ccRCC. [ABSTRACT FROM AUTHOR]

A compact dual‐mode dual‐band bandpass filter (BPF) for WLAN applications is presented. On the basis of a primary passband formed by a ring resonator, a second passband is introduced by taking advantage of its tightly coupled input and output structures. Therefore, a dual‐band performance is achieved without increasing the overall circuit size. Shorting vias and spurlines are adopted separately to realise the dual‐mode excitation of each passband. Finally, a compact dual‐mode BPF centred at 2.4 and 5.2 GHz is designed and fabricated, along with four transmission zeros, leading to sharp skirts and a wide stopband. Experimental results reveal good agreement with simulation results. [ABSTRACT FROM AUTHOR]

Clear-cell renal cell carcinoma (ccRCC) carries a variable prognosis. Prognostic biomarkers can stratify patients according to risk, and can provide crucial information for clinical decision-making. We screened for an autophagy-related long non-coding lncRNA (lncRNA) signature to improve postoperative risk stratification in The Cancer Genome Atlas (TCGA) database. We confirmed this model in ICGC and SYSU cohorts as a significant and independent prognostic signature. Western blotting, autophagic-flux assay and transmission electron microscopy were used to verify that regulation of expression of 8 lncRNAs related to autophagy affected changes in autophagic flow in vitro. Our data suggest that 8-lncRNA signature related to autophagy is a promising prognostic tool in predicting the survival of patients with ccRCC. Combination of this signature with clinical and pathologic parameters could aid accurate risk assessment to guide clinical management, and this 8-lncRNAs signature related to autophagy may serve as a therapeutic target. [ABSTRACT FROM AUTHOR]